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Patent code US10202362

Compile Data Set for Download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM345819
PNG
(US10202362, Compound T2.2)
Show SMILES OC(=O)c1ccc(CN2CCCC(CNc3ccc(Oc4ccc(Cl)cc4)cc3)C2)cc1
Show InChI InChI=1S/C26H27ClN2O3/c27-22-7-11-24(12-8-22)32-25-13-9-23(10-14-25)28-16-20-2-1-15-29(18-20)17-19-3-5-21(6-4-19)26(30)31/h3-14,20,28H,1-2,15-18H2,(H,30,31)
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80n/an/an/an/an/an/a



Celtaxsys, Inc.

US Patent


Assay Description
LTB4 formed was quantified with the HTRF assay in which free LTB4 competes with LTB4-XL665 conjugate (acceptor) for anti-LTB4 monoclonal antibody lab...


US Patent US10202362 (2019)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM345818
PNG
(US10202362, Compound T2.1)
Show SMILES OC(=O)C1CCN(CC1)C(=O)CN1CCC(CC1)Nc1ccc(Oc2ccc(cc2)-c2ncco2)cc1
Show InChI InChI=1S/C28H32N4O5/c33-26(32-16-9-21(10-17-32)28(34)35)19-31-14-11-23(12-15-31)30-22-3-7-25(8-4-22)37-24-5-1-20(2-6-24)27-29-13-18-36-27/h1-8,13,18,21,23,30H,9-12,14-17,19H2,(H,34,35)
PDB
MMDB

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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.10n/an/an/an/an/an/a



Celtaxsys, Inc.

US Patent


Assay Description
LTB4 formed was quantified with the HTRF assay in which free LTB4 competes with LTB4-XL665 conjugate (acceptor) for anti-LTB4 monoclonal antibody lab...


US Patent US10202362 (2019)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM345818
PNG
(US10202362, Compound T2.1)
Show SMILES OC(=O)C1CCN(CC1)C(=O)CN1CCC(CC1)Nc1ccc(Oc2ccc(cc2)-c2ncco2)cc1
Show InChI InChI=1S/C28H32N4O5/c33-26(32-16-9-21(10-17-32)28(34)35)19-31-14-11-23(12-15-31)30-22-3-7-25(8-4-22)37-24-5-1-20(2-6-24)27-29-13-18-36-27/h1-8,13,18,21,23,30H,9-12,14-17,19H2,(H,34,35)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.10n/an/an/an/an/an/a



Celtaxsys, Inc.

US Patent


Assay Description
In brief, the enzyme (29 nM) was incubated with L-alanine-p-nitroanilide (1 mM) in 50 mM HEPES (pH 7.5), 100 mM KCL, 1% DMSO in the absence or presen...


US Patent US10202362 (2019)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM345819
PNG
(US10202362, Compound T2.2)
Show SMILES OC(=O)c1ccc(CN2CCCC(CNc3ccc(Oc4ccc(Cl)cc4)cc3)C2)cc1
Show InChI InChI=1S/C26H27ClN2O3/c27-22-7-11-24(12-8-22)32-25-13-9-23(10-14-25)28-16-20-2-1-15-29(18-20)17-19-3-5-21(6-4-19)26(30)31/h3-14,20,28H,1-2,15-18H2,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 22n/an/an/an/an/an/a



Celtaxsys, Inc.

US Patent


Assay Description
In brief, the enzyme (29 nM) was incubated with L-alanine-p-nitroanilide (1 mM) in 50 mM HEPES (pH 7.5), 100 mM KCL, 1% DMSO in the absence or presen...


US Patent US10202362 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%