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Patent code US10202368

Compile Data Set for Download or QSAR
Found 88 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345930
PNG
(N-(2-Dimethylamino-ethyl)-2-(4-ethyl-2,3,4,5-tetra...)
Show SMILES CCN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C25H33F3N4O2/c1-4-31-14-15-34-24-20(17-31)9-7-11-22(24)29-16-23(33)32(13-12-30(2)3)18-19-8-5-6-10-21(19)25(26,27)28/h5-11,29H,4,12-18H2,1-3H3
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n/an/an/an/a 7n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345932
PNG
(N-(2-Dimethylamino-ethyl)-2-(4-propyl-2,3,4,5-tetr...)
Show SMILES CCCN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H35F3N4O2/c1-4-12-32-15-16-35-25-21(18-32)9-7-11-23(25)30-17-24(34)33(14-13-31(2)3)19-20-8-5-6-10-22(20)26(27,28)29/h5-11,30H,4,12-19H2,1-3H3
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n/an/an/an/a 4n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345935
PNG
(N-[2-(Cyclopropyl-methyl-amino)-ethyl]-2-(4-isobut...)
Show SMILES CC(C)CN1CCOc2c(C1)cccc2NCC(=O)N(CCNCC1CC1)Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C29H39F3N4O2/c1-21(2)18-35-14-15-38-28-24(19-35)7-5-9-26(28)34-17-27(37)36(13-12-33-16-22-10-11-22)20-23-6-3-4-8-25(23)29(30,31)32/h3-9,21-22,33-34H,10-20H2,1-2H3
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n/an/an/an/a 58n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345955
PNG
(2-(4-Cyclopropylmethyl-5-oxo-2,3,4,5-tetrahydro-be...)
Show SMILES CN(C)CCN(Cc1cccc(Cl)c1Cl)C(=O)CNc1cccc2OCCN(CC3CC3)C(=O)c12
Show InChI InChI=1S/C26H32Cl2N4O3/c1-30(2)11-12-31(17-19-5-3-6-20(27)25(19)28)23(33)15-29-21-7-4-8-22-24(21)26(34)32(13-14-35-22)16-18-9-10-18/h3-8,18,29H,9-17H2,1-2H3
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n/an/an/an/a 7.80n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345958
PNG
(2-(4-Cyclopropylmethyl-5-oxo-2,3,4,5-tetrahydro-be...)
Show SMILES CN(C)CCN(Cc1cccc(C)n1)C(=O)CNc1cccc2OCCN(CC3CC3)C(=O)c12
Show InChI InChI=1S/C26H35N5O3/c1-19-6-4-7-21(28-19)18-30(13-12-29(2)3)24(32)16-27-22-8-5-9-23-25(22)26(33)31(14-15-34-23)17-20-10-11-20/h4-9,20,27H,10-18H2,1-3H3
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n/an/an/an/a 24n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345959
PNG
(2-(4-Cyclopropylmethyl-5-oxo-2,3,4,5-tetrahydro-be...)
Show SMILES CC(C)NCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2OCCN(CC3CC3)C(=O)c12
Show InChI InChI=1S/C28H35F3N4O3/c1-19(2)32-12-13-34(18-21-6-3-4-7-22(21)28(29,30)31)25(36)16-33-23-8-5-9-24-26(23)27(37)35(14-15-38-24)17-20-10-11-20/h3-9,19-20,32-33H,10-18H2,1-2H3
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n/an/an/an/a 5n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345985
PNG
(2-(4-Cyclopropylmethyl-5-oxo-2,3,4,5-tetrahydro-be...)
Show SMILES CC(C)NCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2c1OCCN(CC1CC1)C2=O
Show InChI InChI=1S/C28H35F3N4O3/c1-19(2)32-12-13-34(18-21-6-3-4-8-23(21)28(29,30)31)25(36)16-33-24-9-5-7-22-26(24)38-15-14-35(27(22)37)17-20-10-11-20/h3-9,19-20,32-33H,10-18H2,1-2H3
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n/an/an/an/a 5n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345998
PNG
(N-(3-Chloro-pyridin-2-ylmethyl)-2-(4-ethyl-2,3,4,5...)
Show SMILES CCN1CCOc2c(C1)cccc2NCC(=O)N(CCN1CCCC1)Cc1ncccc1Cl
Show InChI InChI=1S/C25H34ClN5O2/c1-2-29-15-16-33-25-20(18-29)7-5-9-22(25)28-17-24(32)31(14-13-30-11-3-4-12-30)19-23-21(26)8-6-10-27-23/h5-10,28H,2-4,11-19H2,1H3
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n/an/an/an/a 19n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345999
PNG
(N-(2-Dimethylamino-ethyl)-2-(4-ethyl-2,3,4,5-tetra...)
Show SMILES CCN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1cnc(s1)C(F)(F)F
Show InChI InChI=1S/C22H30F3N5O2S/c1-4-29-10-11-32-20-16(14-29)6-5-7-18(20)26-13-19(31)30(9-8-28(2)3)15-17-12-27-21(33-17)22(23,24)25/h5-7,12,26H,4,8-11,13-15H2,1-3H3
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n/an/an/an/a 430n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM346004
PNG
(2-(4-Cyclopropylmethyl-2,3,4,5-tetrahydro-benzo[f]...)
Show SMILES CC(C)NCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CN(CC3CC3)CCOc12
Show InChI InChI=1S/C28H37F3N4O2/c1-20(2)32-12-13-35(19-22-6-3-4-8-24(22)28(29,30)31)26(36)16-33-25-9-5-7-23-18-34(17-21-10-11-21)14-15-37-27(23)25/h3-9,20-21,32-33H,10-19H2,1-2H3
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n/an/an/an/a 3n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM346010
PNG
(N-(2-tert-Butylamino-ethyl)-N-(2-chloro-benzyl)-2-...)
Show SMILES CC(C)(C)NCCN(Cc1ccccc1Cl)C(=O)CNc1cccc2OCCN(CC3CC3)Cc12
Show InChI InChI=1S/C28H39ClN4O2/c1-28(2,3)31-13-14-33(19-22-7-4-5-8-24(22)29)27(34)17-30-25-9-6-10-26-23(25)20-32(15-16-35-26)18-21-11-12-21/h4-10,21,30-31H,11-20H2,1-3H3
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n/an/an/an/a 8n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM346012
PNG
(N-(2-tert-Butylamino-ethyl)-2-(4-cyclopropylmethyl...)
Show SMILES CC(C)(C)NCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2OCCN(CC3CC3)Cc12
Show InChI InChI=1S/C29H39F3N4O2/c1-28(2,3)34-13-14-36(19-22-7-4-5-8-24(22)29(30,31)32)27(37)17-33-25-9-6-10-26-23(25)20-35(15-16-38-26)18-21-11-12-21/h4-10,21,33-34H,11-20H2,1-3H3
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n/an/an/an/a 3n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345933
PNG
(N-(3-Bromo-benzyl)-N-(2-dimethylamino-ethyl)-2-(4-...)
Show SMILES CC(C)CN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1cccc(Br)c1
Show InChI InChI=1S/C26H37BrN4O2/c1-20(2)17-30-13-14-33-26-22(19-30)8-6-10-24(26)28-16-25(32)31(12-11-29(3)4)18-21-7-5-9-23(27)15-21/h5-10,15,20,28H,11-14,16-19H2,1-4H3
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n/an/an/an/a 36n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345956
PNG
(2-(4-Cyclopropylmethyl-5-oxo-2,3,4,5-tetrahydro-be...)
Show SMILES CN(C)CCN(Cc1c(Cl)cccc1Cl)C(=O)CNc1cccc2OCCN(CC3CC3)C(=O)c12
Show InChI InChI=1S/C26H32Cl2N4O3/c1-30(2)11-12-31(17-19-20(27)5-3-6-21(19)28)24(33)15-29-22-7-4-8-23-25(22)26(34)32(13-14-35-23)16-18-9-10-18/h3-8,18,29H,9-17H2,1-2H3
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n/an/an/an/a 27n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345968
PNG
(N-(2-tert-Butylamino-ethyl)-2-(4-cyclopropylmethyl...)
Show SMILES CN1CCN(CC2CC2)C(=O)c2cccc(NCC(=O)N(CCNC(C)(C)C)Cc3ccccc3C(F)(F)F)c12
Show InChI InChI=1S/C30H40F3N5O2/c1-29(2,3)35-14-15-37(20-22-8-5-6-10-24(22)30(31,32)33)26(39)18-34-25-11-7-9-23-27(25)36(4)16-17-38(28(23)40)19-21-12-13-21/h5-11,21,34-35H,12-20H2,1-4H3
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n/an/an/an/a 4n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345976
PNG
(2-(4-Cyclopropylmethyl-1-methyl-2,3,4,5-tetrahydro...)
Show SMILES CN1CCN(CC2CC2)Cc2cccc(NCC(=O)N(CCN3CCCC3)Cc3ncccc3C(F)(F)F)c12
Show InChI InChI=1S/C29H39F3N6O/c1-35-14-15-37(19-22-9-10-22)20-23-6-4-8-25(28(23)35)34-18-27(39)38(17-16-36-12-2-3-13-36)21-26-24(29(30,31)32)7-5-11-33-26/h4-8,11,22,34H,2-3,9-10,12-21H2,1H3
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n/an/an/an/a 1n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM346006
PNG
(2-(4-Cyclopropylmethyl-2,3,4,5-tetrahydro-benzo[f]...)
Show SMILES CN(C)CCN(Cc1ncccc1C)C(=O)CNc1cccc2OCCN(CC3CC3)Cc12
Show InChI InChI=1S/C26H37N5O2/c1-20-6-5-11-27-24(20)19-31(13-12-29(2)3)26(32)16-28-23-7-4-8-25-22(23)18-30(14-15-33-25)17-21-9-10-21/h4-8,11,21,28H,9-10,12-19H2,1-3H3
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n/an/an/an/a 23n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345927
PNG
(N-(2-Dimethylamino-ethyl)-2-(4-isobutyl-2,3,4,5-te...)
Show SMILES CC(C)CN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1ncccc1C(F)(F)F
Show InChI InChI=1S/C26H36F3N5O2/c1-19(2)16-33-13-14-36-25-20(17-33)7-5-9-22(25)31-15-24(35)34(12-11-32(3)4)18-23-21(26(27,28)29)8-6-10-30-23/h5-10,19,31H,11-18H2,1-4H3
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n/an/an/an/a 3n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345928
PNG
(N-(3-Chloro-pyridin-2-ylmethyl)-N-(2-dimethylamino...)
Show SMILES CC(C)CN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1ncccc1Cl
Show InChI InChI=1S/C25H36ClN5O2/c1-19(2)16-30-13-14-33-25-20(17-30)7-5-9-22(25)28-15-24(32)31(12-11-29(3)4)18-23-21(26)8-6-10-27-23/h5-10,19,28H,11-18H2,1-4H3
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n/an/an/an/a 9n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345939
PNG
(N-(2-Dimethylamino-ethyl)-2-(4-isobutyl-2,3,4,5-te...)
Show SMILES CC(C)CN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1cc(C)ccn1
Show InChI InChI=1S/C26H39N5O2/c1-20(2)17-30-13-14-33-26-22(18-30)7-6-8-24(26)28-16-25(32)31(12-11-29(4)5)19-23-15-21(3)9-10-27-23/h6-10,15,20,28H,11-14,16-19H2,1-5H3
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n/an/an/an/a 76n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345950
PNG
(2-(3-Acetyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6...)
Show SMILES CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)COc1cccc2CCN(CCc12)C(C)=O
Show InChI InChI=1S/C26H32F3N3O3/c1-19(33)31-13-11-20-8-6-10-24(22(20)12-14-31)35-18-25(34)32(16-15-30(2)3)17-21-7-4-5-9-23(21)26(27,28)29/h4-10H,11-18H2,1-3H3
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n/an/an/an/a 3n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345957
PNG
(N-(2-Chloro-benzyl)-2-(4-cyclopropylmethyl-5-oxo-2...)
Show SMILES CN(C)CCN(Cc1ccccc1Cl)C(=O)CNc1cccc2OCCN(CC3CC3)C(=O)c12
Show InChI InChI=1S/C26H33ClN4O3/c1-29(2)12-13-30(18-20-6-3-4-7-21(20)27)24(32)16-28-22-8-5-9-23-25(22)26(33)31(14-15-34-23)17-19-10-11-19/h3-9,19,28H,10-18H2,1-2H3
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n/an/an/an/a 15n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345979
PNG
(2-(4-Ethyl-5-oxo-2,3,4,5-tetrahydro-benzo[f][1,4]o...)
Show SMILES CCN1CCOc2c(NCC(=O)N(CCNC(C)C)Cc3ccccc3C(F)(F)F)cccc2C1=O
Show InChI InChI=1S/C26H33F3N4O3/c1-4-32-14-15-36-24-20(25(32)35)9-7-11-22(24)31-16-23(34)33(13-12-30-18(2)3)17-19-8-5-6-10-21(19)26(27,28)29/h5-11,18,30-31H,4,12-17H2,1-3H3
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n/an/an/an/a 16n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345993
PNG
(N-(2-tert-Butylamino-ethyl)-2-(4-ethyl-2,3,4,5-tet...)
Show SMILES CCN1CCOc2c(C1)cccc2NCC(=O)N(CCNC(C)(C)C)Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C27H37F3N4O2/c1-5-33-15-16-36-25-21(18-33)10-8-12-23(25)31-17-24(35)34(14-13-32-26(2,3)4)19-20-9-6-7-11-22(20)27(28,29)30/h6-12,31-32H,5,13-19H2,1-4H3
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n/an/an/an/a 4n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345994
PNG
(2-(4-Ethyl-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepi...)
Show SMILES CCN1CCOc2c(C1)cccc2NCC(=O)N(CCNC(C)C)Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H35F3N4O2/c1-4-32-14-15-35-25-21(17-32)9-7-11-23(25)31-16-24(34)33(13-12-30-19(2)3)18-20-8-5-6-10-22(20)26(27,28)29/h5-11,19,30-31H,4,12-18H2,1-3H3
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n/an/an/an/a 4n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM346013
PNG
(N-(2-tert-Butylamino-ethyl)-2-(4-cyclopropylmethyl...)
Show SMILES CC(C)(C)NCCN(Cc1ncccc1C(F)(F)F)C(=O)CNc1cccc2OCCN(CC3CC3)Cc12
Show InChI InChI=1S/C28H38F3N5O2/c1-27(2,3)34-12-13-36(19-24-22(28(29,30)31)6-5-11-32-24)26(37)16-33-23-7-4-8-25-21(23)18-35(14-15-38-25)17-20-9-10-20/h4-8,11,20,33-34H,9-10,12-19H2,1-3H3
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n/an/an/an/a 4n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345926
PNG
(N-(2-Dimethylamino-ethyl)-2-(4-isobutyl-2,3,4,5-te...)
Show SMILES CC(C)CN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C27H37F3N4O2/c1-20(2)17-33-14-15-36-26-22(18-33)9-7-11-24(26)31-16-25(35)34(13-12-32(3)4)19-21-8-5-6-10-23(21)27(28,29)30/h5-11,20,31H,12-19H2,1-4H3
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n/an/an/an/a 8n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345929
PNG
(N-(3-Chloro-pyridin-2-ylmethyl)-N-(2-dimethylamino...)
Show SMILES CCN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1ncccc1Cl
Show InChI InChI=1S/C23H32ClN5O2/c1-4-28-13-14-31-23-18(16-28)7-5-9-20(23)26-15-22(30)29(12-11-27(2)3)17-21-19(24)8-6-10-25-21/h5-10,26H,4,11-17H2,1-3H3
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n/an/an/an/a 24n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345943
PNG
(N-(2-Dimethylamino-ethyl)-2-(4-isobutyl-2,3,4,5-te...)
Show SMILES CC(C)CN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H37F3N4O2/c1-20(2)17-33-13-14-36-26-22(19-33)8-6-10-24(26)31-16-25(35)34(12-11-32(3)4)18-21-7-5-9-23(15-21)27(28,29)30/h5-10,15,20,31H,11-14,16-19H2,1-4H3
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n/an/an/an/a 53n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345946
PNG
(N-(2-(dimethylamino)ethyl)-2-((4-ethyl-2,3,4,5-tet...)
Show SMILES CCN1CCNc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C25H34F3N5O/c1-4-32-13-12-29-24-20(17-32)9-7-11-22(24)30-16-23(34)33(15-14-31(2)3)18-19-8-5-6-10-21(19)25(26,27)28/h5-11,29-30H,4,12-18H2,1-3H3
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n/an/an/an/a 6n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345961
PNG
(2-(4-Cyclopropylmethyl-5-oxo-2,3,4,5-tetrahydro-be...)
Show SMILES CNCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2OCCN(CC3CC3)C(=O)c12
Show InChI InChI=1S/C26H31F3N4O3/c1-30-11-12-32(17-19-5-2-3-6-20(19)26(27,28)29)23(34)15-31-21-7-4-8-22-24(21)25(35)33(13-14-36-22)16-18-9-10-18/h2-8,18,30-31H,9-17H2,1H3
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n/an/an/an/a 12n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345966
PNG
(N-(2-Dimethylamino-ethyl)-2-(4-ethyl-5-oxo-2,3,4,5...)
Show SMILES CCN1CCOc2c(NCC(=O)N(CCN(C)C)Cc3ccccc3C(F)(F)F)cccc2C1=O
Show InChI InChI=1S/C25H31F3N4O3/c1-4-31-14-15-35-23-19(24(31)34)9-7-11-21(23)29-16-22(33)32(13-12-30(2)3)17-18-8-5-6-10-20(18)25(26,27)28/h5-11,29H,4,12-17H2,1-3H3
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n/an/an/an/a 22n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345972
PNG
(2-(1,4-Diethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[e...)
Show SMILES CCN1CCN(CC)C(=O)c2cccc(NCC(=O)N(CCN3CCOCC3)Cc3ncccc3C(F)(F)F)c12
Show InChI InChI=1S/C28H37F3N6O3/c1-3-35-13-14-36(4-2)27(39)21-7-5-9-23(26(21)35)33-19-25(38)37(12-11-34-15-17-40-18-16-34)20-24-22(28(29,30)31)8-6-10-32-24/h5-10,33H,3-4,11-20H2,1-2H3
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n/an/an/an/a 430n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345978
PNG
(2-(4-Cyclopropylmethyl-1-methyl-2,3,4,5-tetrahydro...)
Show SMILES CN1CCN(CC2CC2)Cc2cccc(NCC(=O)N(CCN3CCOCC3)Cc3ncccc3C(F)(F)F)c12
Show InChI InChI=1S/C29H39F3N6O2/c1-35-10-11-37(19-22-7-8-22)20-23-4-2-6-25(28(23)35)34-18-27(39)38(13-12-36-14-16-40-17-15-36)21-26-24(29(30,31)32)5-3-9-33-26/h2-6,9,22,34H,7-8,10-21H2,1H3
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n/an/an/an/a 10n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345982
PNG
(N-(3-Chloro-pyridin-2-ylmethyl)-2-(4-ethyl-5-oxo-2...)
Show SMILES CCN1CCOc2c(NCC(=O)N(CCN3CCCC3)Cc3ncccc3Cl)cccc2C1=O
Show InChI InChI=1S/C25H32ClN5O3/c1-2-30-15-16-34-24-19(25(30)33)7-5-9-21(24)28-17-23(32)31(14-13-29-11-3-4-12-29)18-22-20(26)8-6-10-27-22/h5-10,28H,2-4,11-18H2,1H3
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n/an/an/an/a 260n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345984
PNG
(2-(4-Cyclopropylmethyl-5-oxo-2,3,4,5-tetrahydro-be...)
Show SMILES CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2c1OCCN(CC1CC1)C2=O
Show InChI InChI=1S/C27H33F3N4O3/c1-32(2)12-13-33(18-20-6-3-4-8-22(20)27(28,29)30)24(35)16-31-23-9-5-7-21-25(23)37-15-14-34(26(21)36)17-19-10-11-19/h3-9,19,31H,10-18H2,1-2H3
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n/an/an/an/a 9n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345995
PNG
(N-(2-Dimethylamino-ethyl)-2-(4-ethyl-2,3,4,5-tetra...)
Show SMILES CCN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1ncccc1C(F)(F)F
Show InChI InChI=1S/C24H32F3N5O2/c1-4-31-13-14-34-23-18(16-31)7-5-9-20(23)29-15-22(33)32(12-11-30(2)3)17-21-19(24(25,26)27)8-6-10-28-21/h5-10,29H,4,11-17H2,1-3H3
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n/an/an/an/a 6n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM346003
PNG
(2-(4-Cyclopropylmethyl-2,3,4,5-tetrahydro-benzo[f]...)
Show SMILES CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CN(CC3CC3)CCOc12
Show InChI InChI=1S/C27H35F3N4O2/c1-32(2)12-13-34(19-21-6-3-4-8-23(21)27(28,29)30)25(35)16-31-24-9-5-7-22-18-33(17-20-10-11-20)14-15-36-26(22)24/h3-9,20,31H,10-19H2,1-2H3
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n/an/an/an/a 4n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345931
PNG
(N-(3-Chloro-pyridin-2-ylmethyl)-N-(2-dimethylamino...)
Show SMILES CCCN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1ncccc1Cl
Show InChI InChI=1S/C24H34ClN5O2/c1-4-11-29-14-15-32-24-19(17-29)7-5-9-21(24)27-16-23(31)30(13-12-28(2)3)18-22-20(25)8-6-10-26-22/h5-10,27H,4,11-18H2,1-3H3
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n/an/an/an/a 19n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345936
PNG
(2-(4-Isobutyl-2,3,4,5-tetrahydro-benzo[f][1,4]oxaz...)
Show SMILES CC(C)CN1CCOc2c(C1)cccc2NCC(=O)N(CCN1CCCC1=O)Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C29H37F3N4O3/c1-21(2)18-34-15-16-39-28-23(19-34)8-5-10-25(28)33-17-27(38)36(14-13-35-12-6-11-26(35)37)20-22-7-3-4-9-24(22)29(30,31)32/h3-5,7-10,21,33H,6,11-20H2,1-2H3
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n/an/an/an/a 190n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345938
PNG
(N-(3-Chloro-pyridin-2-ylmethyl)-N-[2-(4,4-difluoro...)
Show SMILES CC(C)CN1CCOc2c(C1)cccc2NCC(=O)N(CCN1CCC(F)(F)CC1)Cc1ncccc1Cl
Show InChI InChI=1S/C28H38ClF2N5O2/c1-21(2)18-35-15-16-38-27-22(19-35)5-3-7-24(27)33-17-26(37)36(20-25-23(29)6-4-10-32-25)14-13-34-11-8-28(30,31)9-12-34/h3-7,10,21,33H,8-9,11-20H2,1-2H3
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n/an/an/an/a 88n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345949
PNG
(N-(2-Dimethylamino-ethyl)-2-[3-(2-methoxy-acetyl)-...)
Show SMILES COCC(=O)N1CCc2cccc(OCC(=O)N(CCN(C)C)Cc3ccccc3C(F)(F)F)c2CC1
Show InChI InChI=1S/C27H34F3N3O4/c1-31(2)15-16-33(17-21-7-4-5-9-23(21)27(28,29)30)26(35)19-37-24-10-6-8-20-11-13-32(14-12-22(20)24)25(34)18-36-3/h4-10H,11-19H2,1-3H3
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n/an/an/an/a 3n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345965
PNG
(N-(2-tert-Butylamino-ethyl)-2-(4-ethyl-5-oxo-2,3,4...)
Show SMILES CCN1CCOc2c(NCC(=O)N(CCNC(C)(C)C)Cc3ccccc3C(F)(F)F)cccc2C1=O
Show InChI InChI=1S/C27H35F3N4O3/c1-5-33-15-16-37-24-20(25(33)36)10-8-12-22(24)31-17-23(35)34(14-13-32-26(2,3)4)18-19-9-6-7-11-21(19)27(28,29)30/h6-12,31-32H,5,13-18H2,1-4H3
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n/an/an/an/a 7n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345973
PNG
(2-(1,4-Diethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[e...)
Show SMILES CCN1CCN(CC)C(=O)c2cccc(NCC(=O)N(CCN3CCCC3)Cc3ncccc3C(F)(F)F)c12
Show InChI InChI=1S/C28H37F3N6O2/c1-3-35-17-18-36(4-2)27(39)21-9-7-11-23(26(21)35)33-19-25(38)37(16-15-34-13-5-6-14-34)20-24-22(28(29,30)31)10-8-12-32-24/h7-12,33H,3-6,13-20H2,1-2H3
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n/an/an/an/a 47n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345975
PNG
(US10202368, Example 50 | {2-[[2-(4-Cyclopropylmeth...)
Show SMILES CC(C)N(CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CN(CC3CC3)CCN(C)c12)C(=O)OC(C)(C)C
Show InChI InChI=1S/C34H48F3N5O3/c1-24(2)42(32(44)45-33(3,4)5)19-18-41(23-26-10-7-8-12-28(26)34(35,36)37)30(43)20-38-29-13-9-11-27-22-40(21-25-14-15-25)17-16-39(6)31(27)29/h7-13,24-25,38H,14-23H2,1-6H3
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n/an/an/an/a 340n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345977
PNG
(2-(4-Cyclopropylmethyl-1-methyl-2,3,4,5-tetrahydro...)
Show SMILES CC(C)NCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CN(CC3CC3)CCN(C)c12
Show InChI InChI=1S/C29H40F3N5O/c1-21(2)33-13-14-37(20-23-7-4-5-9-25(23)29(30,31)32)27(38)17-34-26-10-6-8-24-19-36(18-22-11-12-22)16-15-35(3)28(24)26/h4-10,21-22,33-34H,11-20H2,1-3H3
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n/an/an/an/a 1n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345981
PNG
(N-(2-Dimethylamino-ethyl)-2-(4-ethyl-5-oxo-2,3,4,5...)
Show SMILES CCN1CCOc2c(NCC(=O)N(CCN(C)C)Cc3ncccc3C(F)(F)F)cccc2C1=O
Show InChI InChI=1S/C24H30F3N5O3/c1-4-31-13-14-35-22-17(23(31)34)7-5-9-19(22)29-15-21(33)32(12-11-30(2)3)16-20-18(24(25,26)27)8-6-10-28-20/h5-10,29H,4,11-16H2,1-3H3
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n/an/an/an/a 74n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345996
PNG
(N-(2-Dimethylamino-ethyl)-2-(4-ethyl-2,3,4,5-tetra...)
Show SMILES CCN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1ncccc1C
Show InChI InChI=1S/C24H35N5O2/c1-5-28-14-15-31-24-20(17-28)9-6-10-21(24)26-16-23(30)29(13-12-27(3)4)18-22-19(2)8-7-11-25-22/h6-11,26H,5,12-18H2,1-4H3
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n/an/an/an/a 59n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345997
PNG
(2-(4-Ethyl-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepi...)
Show SMILES CCN1CCOc2c(C1)cccc2NCC(=O)N(CCN1CCCC1)Cc1ncccc1C(F)(F)F
Show InChI InChI=1S/C26H34F3N5O2/c1-2-32-15-16-36-25-20(18-32)7-5-9-22(25)31-17-24(35)34(14-13-33-11-3-4-12-33)19-23-21(26(27,28)29)8-6-10-30-23/h5-10,31H,2-4,11-19H2,1H3
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n/an/an/an/a 5n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM346007
PNG
(2-(4-Cyclopropylmethyl-2,3,4,5-tetrahydro-benzo[f]...)
Show SMILES CN(C)CCN(Cc1cccc(Cl)c1Cl)C(=O)CNc1cccc2OCCN(CC3CC3)Cc12
Show InChI InChI=1S/C26H34Cl2N4O2/c1-30(2)11-12-32(17-20-5-3-6-22(27)26(20)28)25(33)15-29-23-7-4-8-24-21(23)18-31(13-14-34-24)16-19-9-10-19/h3-8,19,29H,9-18H2,1-2H3
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n/an/an/an/a 15n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM346008
PNG
(2-(4-Cyclopropylmethyl-2,3,4,5-tetrahydro-benzo[f]...)
Show SMILES CC(C)NCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2OCCN(CC3CC3)Cc12
Show InChI InChI=1S/C28H37F3N4O2/c1-20(2)32-12-13-35(18-22-6-3-4-7-24(22)28(29,30)31)27(36)16-33-25-8-5-9-26-23(25)19-34(14-15-37-26)17-21-10-11-21/h3-9,20-21,32-33H,10-19H2,1-2H3
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n/an/an/an/a 5n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM346009
PNG
(2-(4-Cyclopropylmethyl-2,3,4,5-tetrahydro-benzo[f]...)
Show SMILES CC(C)NCCN(Cc1ncccc1C(F)(F)F)C(=O)CNc1cccc2OCCN(CC3CC3)Cc12
Show InChI InChI=1S/C27H36F3N5O2/c1-19(2)31-11-12-35(18-24-22(27(28,29)30)5-4-10-32-24)26(36)15-33-23-6-3-7-25-21(23)17-34(13-14-37-25)16-20-8-9-20/h3-7,10,19-20,31,33H,8-9,11-18H2,1-2H3
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n/an/an/an/a 7n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345945
PNG
(2-(4-Acetyl-2,3,4,5-tetrahydro-benzo[f][1,4]oxazep...)
Show SMILES CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CN(CCOc12)C(C)=O
Show InChI InChI=1S/C25H31F3N4O3/c1-18(33)31-13-14-35-24-20(17-31)8-6-10-22(24)29-15-23(34)32(12-11-30(2)3)16-19-7-4-5-9-21(19)25(26,27)28/h4-10,29H,11-17H2,1-3H3
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n/an/an/an/a 73n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345951
PNG
(N-(2-Dimethylamino-ethyl)-2-[3-(2,2,2-trifluoro-ac...)
Show SMILES CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CCN(CCc12)C(=O)C(F)(F)F
Show InChI InChI=1S/C26H30F6N4O2/c1-34(2)14-15-36(17-19-6-3-4-8-21(19)25(27,28)29)23(37)16-33-22-9-5-7-18-10-12-35(13-11-20(18)22)24(38)26(30,31)32/h3-9,33H,10-17H2,1-2H3
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n/an/an/an/a 4n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345952
PNG
(2-(3-Cyclopropylmethyl-2,3,4,5-tetrahydro-1H-benzo...)
Show SMILES CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CCN(CC3CC3)CCc12
Show InChI InChI=1S/C28H37F3N4O/c1-33(2)16-17-35(20-23-6-3-4-8-25(23)28(29,30)31)27(36)18-32-26-9-5-7-22-12-14-34(15-13-24(22)26)19-21-10-11-21/h3-9,21,32H,10-20H2,1-2H3
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n/an/an/an/a 2n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345960
PNG
(US10202368, Example 35 | {2-[[2-(4-Cyclopropylmeth...)
Show SMILES CC(C)N(CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2OCCN(CC3CC3)C(=O)c12)C(=O)OC(C)(C)C
Show InChI InChI=1S/C33H43F3N4O5/c1-22(2)40(31(43)45-32(3,4)5)16-15-38(21-24-9-6-7-10-25(24)33(34,35)36)28(41)19-37-26-11-8-12-27-29(26)30(42)39(17-18-44-27)20-23-13-14-23/h6-12,22-23,37H,13-21H2,1-5H3
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n/an/an/an/a 420n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345962
PNG
(US10202368, Example 37 | {2-[[2-(4-Cyclopropylmeth...)
Show SMILES CN(CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2OCCN(CC3CC3)C(=O)c12)C(=O)OC(C)(C)C
Show InChI InChI=1S/C31H39F3N4O5/c1-30(2,3)43-29(41)36(4)14-15-37(20-22-8-5-6-9-23(22)31(32,33)34)26(39)18-35-24-10-7-11-25-27(24)28(40)38(16-17-42-25)19-21-12-13-21/h5-11,21,35H,12-20H2,1-4H3
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n/an/an/an/a 410n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345970
PNG
(N-(3-Chloro-pyridin-2-ylmethyl)-2-(4-cyclopropylme...)
Show SMILES CN(C)CCN(Cc1ncccc1Cl)C(=O)CNc1cccc2c1N(C)CCN(CC1CC1)C2=O
Show InChI InChI=1S/C26H35ClN6O2/c1-30(2)12-14-32(18-23-21(27)7-5-11-28-23)24(34)16-29-22-8-4-6-20-25(22)31(3)13-15-33(26(20)35)17-19-9-10-19/h4-8,11,19,29H,9-10,12-18H2,1-3H3
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n/an/an/an/a 50n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345988
PNG
(2-(4-cyclopropylmethyl-3-oxo-2,3,4,5-tetrahydro-be...)
Show SMILES FC(F)(F)c1cccnc1CN(CCN1CCCC1)C(=O)CNc1cccc2CN(CC3CC3)C(=O)COc12
Show InChI InChI=1S/C28H34F3N5O3/c29-28(30,31)22-6-4-10-32-24(22)18-35(14-13-34-11-1-2-12-34)25(37)15-33-23-7-3-5-21-17-36(16-20-8-9-20)26(38)19-39-27(21)23/h3-7,10,20,33H,1-2,8-9,11-19H2
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n/an/an/an/a 18n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM346001
PNG
(2-(4-Cyclopropylmethyl-2,3,4,5-tetrahydro-benzo[f]...)
Show SMILES FC(F)(F)c1cccnc1CN(CCN1CCCC1)C(=O)CNc1cccc2CN(CC3CC3)CCOc12
Show InChI InChI=1S/C28H36F3N5O2/c29-28(30,31)23-6-4-10-32-25(23)20-36(14-13-34-11-1-2-12-34)26(37)17-33-24-7-3-5-22-19-35(18-21-8-9-21)15-16-38-27(22)24/h3-7,10,21,33H,1-2,8-9,11-20H2
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n/an/an/an/a 2n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345934
PNG
(N-(2-Dimethylamino-ethyl)-2-(4-isobutyl-2,3,4,5-te...)
Show SMILES COc1ccnc(CN(CCN(C)C)C(=O)CNc2cccc3CN(CC(C)C)CCOc23)c1
Show InChI InChI=1S/C26H39N5O3/c1-20(2)17-30-13-14-34-26-21(18-30)7-6-8-24(26)28-16-25(32)31(12-11-29(3)4)19-22-15-23(33-5)9-10-27-22/h6-10,15,20,28H,11-14,16-19H2,1-5H3
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n/an/an/an/a 200n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345937
PNG
(N-(2,4-Difluoro-benzyl)-2-(4-isobutyl-2,3,4,5-tetr...)
Show SMILES CC(C)CN1CCOc2c(C1)cccc2NCC(=O)N(CCN1CCCC1)Cc1ccc(F)cc1F
Show InChI InChI=1S/C28H38F2N4O2/c1-21(2)18-33-14-15-36-28-23(19-33)6-5-7-26(28)31-17-27(35)34(13-12-32-10-3-4-11-32)20-22-8-9-24(29)16-25(22)30/h5-9,16,21,31H,3-4,10-15,17-20H2,1-2H3
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n/an/an/an/a 14n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345940
PNG
(N-(2-Chloro-benzyl)-2-(4-isobutyl-2,3,4,5-tetrahyd...)
Show SMILES CC(C)CN1CCOc2c(C1)cccc2NCC(=O)N(CCN1CCCC1)Cc1ccccc1Cl
Show InChI InChI=1S/C28H39ClN4O2/c1-22(2)19-32-16-17-35-28-24(20-32)9-7-11-26(28)30-18-27(34)33(15-14-31-12-5-6-13-31)21-23-8-3-4-10-25(23)29/h3-4,7-11,22,30H,5-6,12-21H2,1-2H3
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n/an/an/an/a 11n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345942
PNG
(N-(2-Dimethylamino-ethyl)-N-(4-fluoro-2-trifluorom...)
Show SMILES CC(C)CN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1ccc(F)cc1C(F)(F)F
Show InChI InChI=1S/C27H36F4N4O2/c1-19(2)16-34-12-13-37-26-21(17-34)6-5-7-24(26)32-15-25(36)35(11-10-33(3)4)18-20-8-9-22(28)14-23(20)27(29,30)31/h5-9,14,19,32H,10-13,15-18H2,1-4H3
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n/an/an/an/a 59n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345944
PNG
(N-(2,6-Difluoro-benzyl)-N-(2-dimethylamino-ethyl)-...)
Show SMILES CC(C)CN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)Cc1c(F)cccc1F
Show InChI InChI=1S/C26H36F2N4O2/c1-19(2)16-31-13-14-34-26-20(17-31)7-5-10-24(26)29-15-25(33)32(12-11-30(3)4)18-21-22(27)8-6-9-23(21)28/h5-10,19,29H,11-18H2,1-4H3
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n/an/an/an/a 12n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345947
PNG
(2-(4-Cyclopropylmethyl-2,3,4,5-tetrahydro-benzo[f]...)
Show SMILES CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2OCCN(CC3CC3)Cc12
Show InChI InChI=1S/C27H35F3N4O2/c1-32(2)12-13-34(18-21-6-3-4-7-23(21)27(28,29)30)26(35)16-31-24-8-5-9-25-22(24)19-33(14-15-36-25)17-20-10-11-20/h3-9,20,31H,10-19H2,1-2H3
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n/an/an/an/a 4n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345954
PNG
(N-(2-tert-Butylamino-ethyl)-2-(4-cyclopropylmethyl...)
Show SMILES CC(C)(C)NCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2OCCN(CC3CC3)C(=O)c12
Show InChI InChI=1S/C29H37F3N4O3/c1-28(2,3)34-13-14-35(19-21-7-4-5-8-22(21)29(30,31)32)25(37)17-33-23-9-6-10-24-26(23)27(38)36(15-16-39-24)18-20-11-12-20/h4-10,20,33-34H,11-19H2,1-3H3
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n/an/an/an/a 3n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345964
PNG
(N-(2-Dimethylamino-ethyl)-2-(4-ethyl-5-oxo-2,3,4,5...)
Show SMILES CCN1CCOc2c(NCC(=O)N(CCN(C)C)Cc3ncccc3C)cccc2C1=O
Show InChI InChI=1S/C24H33N5O3/c1-5-28-14-15-32-23-19(24(28)31)9-6-10-20(23)26-16-22(30)29(13-12-27(3)4)17-21-18(2)8-7-11-25-21/h6-11,26H,5,12-17H2,1-4H3
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n/an/an/an/a 400n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345967
PNG
(2-(4-Cyclopropylmethyl-1-methyl-5-oxo-2,3,4,5-tetr...)
Show SMILES CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2c1N(C)CCN(CC1CC1)C2=O
Show InChI InChI=1S/C28H36F3N5O2/c1-33(2)13-15-35(19-21-7-4-5-9-23(21)28(29,30)31)25(37)17-32-24-10-6-8-22-26(24)34(3)14-16-36(27(22)38)18-20-11-12-20/h4-10,20,32H,11-19H2,1-3H3
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n/an/an/an/a 7n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345969
PNG
(2-(4-Cyclopropylmethyl-1-methyl-5-oxo-2,3,4,5-tetr...)
Show SMILES CN(C)CCN(Cc1ncccc1C)C(=O)CNc1cccc2c1N(C)CCN(CC1CC1)C2=O
Show InChI InChI=1S/C27H38N6O2/c1-20-7-6-12-28-24(20)19-32(15-13-30(2)3)25(34)17-29-23-9-5-8-22-26(23)31(4)14-16-33(27(22)35)18-21-10-11-21/h5-9,12,21,29H,10-11,13-19H2,1-4H3
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n/an/an/an/a 130n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345983
PNG
(N-(3-Chloro-pyridin-2-ylmethyl)-N-(2-dimethylamino...)
Show SMILES CCN1CCOc2c(NCC(=O)N(CCN(C)C)Cc3ncccc3Cl)cccc2C1=O
Show InChI InChI=1S/C23H30ClN5O3/c1-4-28-13-14-32-22-17(23(28)31)7-5-9-19(22)26-15-21(30)29(12-11-27(2)3)16-20-18(24)8-6-10-25-20/h5-10,26H,4,11-16H2,1-3H3
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n/an/an/an/a 260n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345987
PNG
(2-(4-Cyclopropylmethyl-5-oxo-2,3,4,5-tetrahydro-be...)
Show SMILES FC(F)(F)c1cccnc1CN(CCN1CCCC1)C(=O)CNc1cccc2c1OCCN(CC1CC1)C2=O
Show InChI InChI=1S/C28H34F3N5O3/c29-28(30,31)22-6-4-10-32-24(22)19-35(14-13-34-11-1-2-12-34)25(37)17-33-23-7-3-5-21-26(23)39-16-15-36(27(21)38)18-20-8-9-20/h3-7,10,20,33H,1-2,8-9,11-19H2
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n/an/an/an/a 7n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345989
PNG
(N-(2-tert-butylamino-ethyl)-2-(4-cyclopropylmethyl...)
Show SMILES CC(C)(C)NCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CN(CC3CC3)C(=O)COc12
Show InChI InChI=1S/C29H37F3N4O3/c1-28(2,3)34-13-14-35(17-21-7-4-5-9-23(21)29(30,31)32)25(37)15-33-24-10-6-8-22-18-36(16-20-11-12-20)26(38)19-39-27(22)24/h4-10,20,33-34H,11-19H2,1-3H3
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n/an/an/an/a 18n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM346000
PNG
(N-(5-Chloro-1-methyl-3-trifluoromethyl-1H-pyrazol-...)
Show SMILES CCN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C)C)C(C)c1c(Cl)[nH]nc1C(F)(F)F
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n/an/an/an/a 280n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345941
PNG
(2-(4-Isobutyl-2,3,4,5-tetrahydro-benzo[f][1,4]oxaz...)
Show SMILES CC(C)CN1CCOc2c(C1)cccc2NCC(=O)N(CCN1CCOCC1)Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C29H39F3N4O3/c1-22(2)19-35-14-17-39-28-24(20-35)7-5-9-26(28)33-18-27(37)36(11-10-34-12-15-38-16-13-34)21-23-6-3-4-8-25(23)29(30,31)32/h3-9,22,33H,10-21H2,1-2H3
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n/an/an/an/a 74n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345948
PNG
(2-(3-Cyclopropylmethyl-2,3,4,5-tetrahydro-1H-benzo...)
Show SMILES CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)COc1cccc2CCN(CC3CC3)CCc12
Show InChI InChI=1S/C28H36F3N3O2/c1-32(2)16-17-34(19-23-6-3-4-8-25(23)28(29,30)31)27(35)20-36-26-9-5-7-22-12-14-33(15-13-24(22)26)18-21-10-11-21/h3-9,21H,10-20H2,1-2H3
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n/an/an/an/a 1n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345953
PNG
(2-(2-Cyclopropylmethyl-2,3,4,5-tetrahydro-1H-benzo...)
Show SMILES CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CN(CC3CC3)CCCc12
Show InChI InChI=1S/C28H37F3N4O/c1-33(2)15-16-35(20-23-7-3-4-10-25(23)28(29,30)31)27(36)17-32-26-11-5-8-22-19-34(18-21-12-13-21)14-6-9-24(22)26/h3-5,7-8,10-11,21,32H,6,9,12-20H2,1-2H3
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n/an/an/an/a 3n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345963
PNG
(2-(4-Cyclopropylmethyl-5-oxo-2,3,4,5-tetrahydro-be...)
Show SMILES CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2OCCN(CC3CC3)C(=O)c12
Show InChI InChI=1S/C27H33F3N4O3/c1-32(2)12-13-33(18-20-6-3-4-7-21(20)27(28,29)30)24(35)16-31-22-8-5-9-23-25(22)26(36)34(14-15-37-23)17-19-10-11-19/h3-9,19,31H,10-18H2,1-2H3
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n/an/an/an/a 4n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345971
PNG
(2-(4-Cyclopropylmethyl-1-methyl-5-oxo-2,3,4,5-tetr...)
Show SMILES CC(C)NCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2c1N(C)CCN(CC1CC1)C2=O
Show InChI InChI=1S/C29H38F3N5O2/c1-20(2)33-13-14-36(19-22-7-4-5-9-24(22)29(30,31)32)26(38)17-34-25-10-6-8-23-27(25)35(3)15-16-37(28(23)39)18-21-11-12-21/h4-10,20-21,33-34H,11-19H2,1-3H3
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n/an/an/an/a 5n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345974
PNG
(2-(4-Cyclopropylmethyl-1-methyl-2,3,4,5-tetrahydro...)
Show SMILES CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CN(CC3CC3)CCN(C)c12
Show InChI InChI=1S/C28H38F3N5O/c1-33(2)13-16-36(20-22-7-4-5-9-24(22)28(29,30)31)26(37)17-32-25-10-6-8-23-19-35(18-21-11-12-21)15-14-34(3)27(23)25/h4-10,21,32H,11-20H2,1-3H3
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n/an/an/an/a 2n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345980
PNG
(2-(4-Ethyl-5-oxo-2,3,4,5-tetrahydro-benzo[f][1,4]o...)
Show SMILES CCN1CCOc2c(NCC(=O)N(CCN3CCCC3)Cc3ncccc3C(F)(F)F)cccc2C1=O
Show InChI InChI=1S/C26H32F3N5O3/c1-2-33-15-16-37-24-19(25(33)36)7-5-9-21(24)31-17-23(35)34(14-13-32-11-3-4-12-32)18-22-20(26(27,28)29)8-6-10-30-22/h5-10,31H,2-4,11-18H2,1H3
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n/an/an/an/a 60n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345986
PNG
(N-(2-tert-Butylamino-ethyl)-2-(4-cyclopropylmethyl...)
Show SMILES CC(C)(C)NCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2c1OCCN(CC1CC1)C2=O
Show InChI InChI=1S/C29H37F3N4O3/c1-28(2,3)34-13-14-35(19-21-7-4-5-9-23(21)29(30,31)32)25(37)17-33-24-10-6-8-22-26(24)39-16-15-36(27(22)38)18-20-11-12-20/h4-10,20,33-34H,11-19H2,1-3H3
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n/an/an/an/a 2n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345990
PNG
(2-(4-Cyclopropylmethyl-3-oxo-2,3,4,5-tetrahydro-be...)
Show SMILES CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CN(CC3CC3)C(=O)COc12
Show InChI InChI=1S/C27H33F3N4O3/c1-32(2)12-13-33(16-20-6-3-4-8-22(20)27(28,29)30)24(35)14-31-23-9-5-7-21-17-34(15-19-10-11-19)25(36)18-37-26(21)23/h3-9,19,31H,10-18H2,1-2H3
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n/an/an/an/a 37n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345991
PNG
(2-(4-Cyclopropylmethyl-3-oxo-2,3,4,5-tetrahydro-be...)
Show SMILES CC(C)NCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CN(CC3CC3)C(=O)COc12
Show InChI InChI=1S/C28H35F3N4O3/c1-19(2)32-12-13-34(16-21-6-3-4-8-23(21)28(29,30)31)25(36)14-33-24-9-5-7-22-17-35(15-20-10-11-20)26(37)18-38-27(22)24/h3-9,19-20,32-33H,10-18H2,1-2H3
UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/an/a 15n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM345992
PNG
(US10202368, Example 69 | {2-[[2-(4-Ethyl-2,3,4,5-t...)
Show SMILES CCN1CCOc2c(C1)cccc2NCC(=O)N(CCN(C(C)C)C(=O)OC(C)(C)C)Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C31H43F3N4O4/c1-7-36-17-18-41-28-24(20-36)12-10-14-26(28)35-19-27(39)37(21-23-11-8-9-13-25(23)31(32,33)34)15-16-38(22(2)3)29(40)42-30(4,5)6/h8-14,22,35H,7,15-21H2,1-6H3
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n/an/an/an/a 430n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM346002
PNG
(N-(2-tert-Butylamino-ethyl)-2-(4-cyclopropylmethyl...)
Show SMILES CC(C)(C)NCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CN(CC3CC3)CCOc12
Show InChI InChI=1S/C29H39F3N4O2/c1-28(2,3)34-13-14-36(20-22-7-4-5-9-24(22)29(30,31)32)26(37)17-33-25-10-6-8-23-19-35(18-21-11-12-21)15-16-38-27(23)25/h4-10,21,33-34H,11-20H2,1-3H3
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US Patent
n/an/an/an/a 3n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM346005
PNG
(N-(2-Chloro-benzyl)-2-(4-cyclopropylmethyl-2,3,4,5...)
Show SMILES CN(C)CCN(Cc1ccccc1Cl)C(=O)CNc1cccc2OCCN(CC3CC3)Cc12
Show InChI InChI=1S/C26H35ClN4O2/c1-29(2)12-13-31(18-21-6-3-4-7-23(21)27)26(32)16-28-24-8-5-9-25-22(24)19-30(14-15-33-25)17-20-10-11-20/h3-9,20,28H,10-19H2,1-2H3
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n/an/an/an/a 14n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))
BDBM346011
PNG
(N-(2-tert-Butylamino-ethyl)-N-(3-chloro-pyridin-2-...)
Show SMILES CC(C)(C)NCCN(Cc1ncccc1Cl)C(=O)CNc1cccc2OCCN(CC3CC3)Cc12
Show InChI InChI=1S/C27H38ClN5O2/c1-27(2,3)31-12-13-33(19-24-22(28)6-5-11-29-24)26(34)16-30-23-7-4-8-25-21(23)18-32(14-15-35-25)17-20-9-10-20/h4-8,11,20,30-31H,9-10,12-19H2,1-3H3
UniProtKB/SwissProt

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US Patent
n/an/an/an/a 10n/an/an/an/a



IDORSIA PHARMACEUTICALS LTD.

US Patent


Assay Description
The assay is using the PathHunter CHO-K1 CXCR7 β-arrestin cell line from DiscoverX. The system is based on the Enzyme Fragment Complementation T...


US Patent US10202368 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%