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Patent code US10202373

Compile Data Set for Download or QSAR
Found 49 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346196
PNG
(US10202373, Compound I-8 | US10202373, Example 9)
Show SMILES CC(=O)Nc1cc(c(F)cn1)-c1cncc2n(ccc12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C17H15FN4O3S/c1-10(23)21-17-6-13(15(18)8-20-17)14-7-19-9-16-12(14)4-5-22(16)26(24,25)11-2-3-11/h4-9,11H,2-3H2,1H3,(H,20,21,23)
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n/an/a 30n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346223
PNG
(US10202373, Compound I-37 | US10202373, Example 3L)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cncc2n(ccc12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C17H16N4O3S/c1-11(22)20-17-8-12(4-6-19-17)15-9-18-10-16-14(15)5-7-21(16)25(23,24)13-2-3-13/h4-10,13H,2-3H2,1H3,(H,19,20,22)
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n/an/a<10n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346210
PNG
(US10202373, Compound I-23 | US10202373, Example 3K)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)N1CCCC1
Show InChI InChI=1S/C19H21N5O3S/c1-13-19-16(6-10-24(19)28(26,27)23-8-3-4-9-23)17(12-21-13)15-5-7-20-18(11-15)22-14(2)25/h5-7,10-12H,3-4,8-9H2,1-2H3,(H,20,22,25)
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n/an/a<10n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346226
PNG
(US10202373, Compound I-40 | US10202373, Example 3I)
Show SMILES CC(=O)Nc1cccc(c1)-c1cnc(C)c2[nH]ccc12
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n/an/a 75n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346227
PNG
(US10202373, Compound I-41 | US10202373, Example 13)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(CN)c2n(ccc12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C18H19N5O3S/c1-11(24)22-17-8-12(4-6-20-17)15-10-21-16(9-19)18-14(15)5-7-23(18)27(25,26)13-2-3-13/h4-8,10,13H,2-3,9,19H2,1H3,(H,20,22,24)
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n/an/a 30n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346228
PNG
(US10202373, Compound I-42 | US10202373, Example 10...)
Show SMILES CCOC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C19H20N4O4S/c1-3-27-19(24)22-17-10-13(6-8-20-17)16-11-21-12(2)18-15(16)7-9-23(18)28(25,26)14-4-5-14/h6-11,14H,3-5H2,1-2H3,(H,20,22,24)
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n/an/a<10n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346235
PNG
(US10202373, Compound I-49 | US10202373, Example 14)
Show SMILES O=S(=O)(C1CC1)n1ccc2c(cncc12)-c1ccnc(Nc2ccncn2)c1
Show InChI InChI=1S/C19H16N6O2S/c26-28(27,14-1-2-14)25-8-5-15-16(10-21-11-17(15)25)13-3-7-22-19(9-13)24-18-4-6-20-12-23-18/h3-12,14H,1-2H2,(H,20,22,23,24)
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n/an/a 30n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346212
PNG
(US10202373, Compound I-25 | US10202373, Example 10...)
Show SMILES CCOC(=O)Nc1cc(ccn1)-c1cncc2n(ccc12)S(C)(=O)=O
Show InChI InChI=1S/C16H16N4O4S/c1-3-24-16(21)19-15-8-11(4-6-18-15)13-9-17-10-14-12(13)5-7-20(14)25(2,22)23/h4-10H,3H2,1-2H3,(H,18,19,21)
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n/an/a<10n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346218
PNG
(US10202373, Compound I-32 | US10202373, Example 3U)
Show SMILES CS(=O)(=O)n1ccc2c(cncc12)-c1ccnc(N)c1
Show InChI InChI=1S/C13H12N4O2S/c1-20(18,19)17-5-3-10-11(7-15-8-12(10)17)9-2-4-16-13(14)6-9/h2-8H,1H3,(H2,14,16)
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n/an/a>100n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346221
PNG
(US10202373, Compound I-35 | US10202373, Example 11)
Show SMILES Cc1ncc(-c2ccnc(NC(=O)C3CC3(F)F)c2)c2ccn(c12)S(C)(=O)=O
Show InChI InChI=1S/C18H16F2N4O3S/c1-10-16-12(4-6-24(16)28(2,26)27)13(9-22-10)11-3-5-21-15(7-11)23-17(25)14-8-18(14,19)20/h3-7,9,14H,8H2,1-2H3,(H,21,23,25)
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n/an/a<10n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346229
PNG
(US10202373, Compound I-43 | US10202373, Example 4)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C18H18N4O4S/c1-11-17-14(6-8-22(17)27(24,25)13-3-4-13)15(10-20-11)12-5-7-19-16(9-12)21-18(23)26-2/h5-10,13H,3-4H2,1-2H3,(H,19,21,23)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346230
PNG
(US10202373, Compound I-44 | US10202373, Example 3B)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C18H18N4O3S/c1-11-18-15(6-8-22(18)26(24,25)14-3-4-14)16(10-20-11)13-5-7-19-17(9-13)21-12(2)23/h5-10,14H,3-4H2,1-2H3,(H,19,21,23)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346199
PNG
(US10202373, Compound I-11 | US10202373, Example 3C)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C21H16F2N4O3S/c1-12-21-16(17(11-25-12)14-5-7-24-20(9-14)26-13(2)28)6-8-27(21)31(29,30)19-4-3-15(22)10-18(19)23/h3-11H,1-2H3,(H,24,26,28)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346203
PNG
(US10202373, Compound I-15 | US10202373, Example 3X)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)CC(C)C
Show InChI InChI=1S/C19H22N4O4S/c1-12(2)11-28(25,26)23-8-6-15-16(10-21-13(3)18(15)23)14-5-7-20-17(9-14)22-19(24)27-4/h5-10,12H,11H2,1-4H3,(H,20,22,24)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346204
PNG
(US10202373, Compound I-16 | US10202373, Example 3M)
Show SMILES CCS(=O)(=O)n1ccc2c(cnc(C)c12)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C17H18N4O3S/c1-4-25(23,24)21-8-6-14-15(10-19-11(2)17(14)21)13-5-7-18-16(9-13)20-12(3)22/h5-10H,4H2,1-3H3,(H,18,20,22)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346205
PNG
(US10202373, Compound I-17 | US10202373, Example 4F)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cncc2n(ccc12)S(=O)(=O)N(C)C
Show InChI InChI=1S/C16H17N5O4S/c1-20(2)26(23,24)21-7-5-12-13(9-17-10-14(12)21)11-4-6-18-15(8-11)19-16(22)25-3/h4-10H,1-3H3,(H,18,19,22)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346213
PNG
(US10202373, Compound I-27 | US10202373, Example 12)
Show SMILES O=C(Cc1nnn[nH]1)Nc1cc(ccn1)-c1cncc2n(ccc12)S(=O)(=O)C1CC1
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346217
PNG
(US10202373, Compound I-31 | US10202373, Example 6)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cncc2n(c(C)cc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H18N4O3S/c1-14-10-18-19(16-8-9-23-21(11-16)24-15(2)26)12-22-13-20(18)25(14)29(27,28)17-6-4-3-5-7-17/h3-13H,1-2H3,(H,23,24,26)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346225
PNG
(US10202373, Compound I-39 | US10202373, Example 3D)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cncc2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H16N4O3S/c1-14(25)23-20-11-15(7-9-22-20)18-12-21-13-19-17(18)8-10-24(19)28(26,27)16-5-3-2-4-6-16/h2-13H,1H3,(H,22,23,25)
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n/an/a<10n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346237
PNG
(US10202373, Compound I-51 | US10202373, Example 15)
Show SMILES Cc1nccc(Nc2cc(ccn2)-c2cnc(C)c3[nH]ccc23)n1
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n/an/a 30n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346190
PNG
(US10202373, Compound I-2 | US10202373, Example 4B)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H18N4O4S/c1-14-20-17(9-11-25(20)30(27,28)16-6-4-3-5-7-16)18(13-23-14)15-8-10-22-19(12-15)24-21(26)29-2/h3-13H,1-2H3,(H,22,24,26)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346191
PNG
(US10202373, Compound I-3 | US10202373, Example 3N)
Show SMILES CCc1ncc(-c2ccnc(NC(C)=O)c2)c2ccn(c12)S(C)(=O)=O
Show InChI InChI=1S/C17H18N4O3S/c1-4-15-17-13(6-8-21(17)25(3,23)24)14(10-19-15)12-5-7-18-16(9-12)20-11(2)22/h5-10H,4H2,1-3H3,(H,18,20,22)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346211
PNG
(US10202373, Compound I-24 | US10202373, Example 6)
Show SMILES CCc1cc2c(cncc2n1S(=O)(=O)c1ccccc1)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C22H20N4O3S/c1-3-17-12-19-20(16-9-10-24-22(11-16)25-15(2)27)13-23-14-21(19)26(17)30(28,29)18-7-5-4-6-8-18/h4-14H,3H2,1-2H3,(H,24,25,27)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346231
PNG
(US10202373, Compound I-45 | US10202373, Example 3A)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(C)(=O)=O
Show InChI InChI=1S/C16H16N4O3S/c1-10-16-13(5-7-20(16)24(3,22)23)14(9-18-10)12-4-6-17-15(8-12)19-11(2)21/h4-9H,1-3H3,(H,17,19,21)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346236
PNG
(US10202373, Compound I-50 | US10202373, Example 14)
Show SMILES N(c1ccncn1)c1cc(ccn1)-c1cncc2[nH]ccc12
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346197
PNG
(US10202373, Compound I-9 | US10202373, Example 3J)
Show SMILES CS(=O)(=O)n1ccc2c(cncc12)-c1ccnc(Nc2ncco2)c1
Show InChI InChI=1S/C16H13N5O3S/c1-25(22,23)21-6-3-12-13(9-17-10-14(12)21)11-2-4-18-15(8-11)20-16-19-5-7-24-16/h2-10H,1H3,(H,18,19,20)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346198
PNG
(US10202373, Compound I-10 | US10202373, Example 4C)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(OC)c2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H18N4O5S/c1-29-20-19-16(9-11-25(19)31(27,28)15-6-4-3-5-7-15)17(13-23-20)14-8-10-22-18(12-14)24-21(26)30-2/h3-13H,1-2H3,(H,22,24,26)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346216
PNG
(US10202373, Compound I-30 | US10202373, Example 4H)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cncc2n(ccc12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C17H16N4O4S/c1-25-17(22)20-16-8-11(4-6-19-16)14-9-18-10-15-13(14)5-7-21(15)26(23,24)12-2-3-12/h4-10,12H,2-3H2,1H3,(H,19,20,22)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346233
PNG
(US10202373, Compound I-47 | US10202373, Example 10)
Show SMILES CCOC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C22H20N4O4S/c1-3-30-22(27)25-20-13-16(9-11-23-20)19-14-24-15(2)21-18(19)10-12-26(21)31(28,29)17-7-5-4-6-8-17/h4-14H,3H2,1-2H3,(H,23,25,27)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346234
PNG
(US10202373, Compound I-48 | US10202373, Example 10...)
Show SMILES Cc1ncc(-c2ccnc(NC(=O)CO)c2)c2ccn(c12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C18H18N4O4S/c1-11-18-14(5-7-22(18)27(25,26)13-2-3-13)15(9-20-11)12-4-6-19-16(8-12)21-17(24)10-23/h4-9,13,23H,2-3,10H2,1H3,(H,19,21,24)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346187
PNG
(US10202373, Compound I-1 | US10202373, Example 4D)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(OC)c2n(ccc12)S(C)(=O)=O
Show InChI InChI=1S/C16H16N4O5S/c1-24-15-14-11(5-7-20(14)26(3,22)23)12(9-18-15)10-4-6-17-13(8-10)19-16(21)25-2/h4-9H,1-3H3,(H,17,19,21)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346192
PNG
(US10202373, Compound I-4 | US10202373, Example 3)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H18N4O3S/c1-14-21-18(9-11-25(21)29(27,28)17-6-4-3-5-7-17)19(13-23-14)16-8-10-22-20(12-16)24-15(2)26/h3-13H,1-2H3,(H,22,24,26)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346193
PNG
(US10202373, Compound I-5 | US10202373, Example 3T)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(cc(C)c12)S(C)(=O)=O
Show InChI InChI=1S/C17H18N4O3S/c1-10-9-21(25(4,23)24)17-11(2)19-8-14(16(10)17)13-5-6-18-15(7-13)20-12(3)22/h5-9H,1-4H3,(H,18,20,22)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346194
PNG
(US10202373, Compound I-6 | US10202373, Example 4E)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)N(C)C
Show InChI InChI=1S/C17H19N5O4S/c1-11-16-13(6-8-22(16)27(24,25)21(2)3)14(10-19-11)12-5-7-18-15(9-12)20-17(23)26-4/h5-10H,1-4H3,(H,18,20,23)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346206
PNG
(US10202373, Compound I-18 | US10202373, Example 3P)
Show SMILES CN(C)c1ncc(-c2ccnc(NC(C)=O)c2)c2ccn(c12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C19H21N5O3S/c1-12(25)22-17-10-13(6-8-20-17)16-11-21-19(23(2)3)18-15(16)7-9-24(18)28(26,27)14-4-5-14/h6-11,14H,4-5H2,1-3H3,(H,20,22,25)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346209
PNG
(US10202373, Compound I-22 | US10202373, Example 5)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cncc2n(ncc12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C16H15N5O3S/c1-10(22)20-16-6-11(4-5-18-16)13-7-17-9-15-14(13)8-19-21(15)25(23,24)12-2-3-12/h4-9,12H,2-3H2,1H3,(H,18,20,22)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346219
PNG
(US10202373, Compound I-33 | US10202373, Example 3V)
Show SMILES CN(C)S(=O)(=O)n1ccc2c(cncc12)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C16H17N5O3S/c1-11(22)19-16-8-12(4-6-18-16)14-9-17-10-15-13(14)5-7-21(15)25(23,24)20(2)3/h4-10H,1-3H3,(H,18,19,22)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346220
PNG
(US10202373, Compound I-34 | US10202373, Example 3O)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C22H20N4O3S/c1-14-6-4-5-7-20(14)30(28,29)26-11-9-18-19(13-24-15(2)22(18)26)17-8-10-23-21(12-17)25-16(3)27/h4-13H,1-3H3,(H,23,25,27)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346222
PNG
(US10202373, Compound I-36 | US10202373, Example 3G)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(CC3CC3)ccc12
Show InChI InChI=1S/C19H20N4O/c1-12-19-16(6-8-23(19)11-14-3-4-14)17(10-21-12)15-5-7-20-18(9-15)22-13(2)24/h5-10,14H,3-4,11H2,1-2H3,(H,20,22,24)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346224
PNG
(US10202373, Compound I-38 | US10202373, Example 3W)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(C)(=O)=O
Show InChI InChI=1S/C16H16N4O4S/c1-10-15-12(5-7-20(15)25(3,22)23)13(9-18-10)11-4-6-17-14(8-11)19-16(21)24-2/h4-9H,1-3H3,(H,17,19,21)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346195
PNG
(US10202373, Compound I-7 | US10202373, Example 3F)
Show SMILES CN(C)S(=O)(=O)n1ccc2c(cnc(C)c12)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C17H19N5O3S/c1-11-17-14(6-8-22(17)26(24,25)21(3)4)15(10-19-11)13-5-7-18-16(9-13)20-12(2)23/h5-10H,1-4H3,(H,18,20,23)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346202
PNG
(US10202373, Compound I-14 | US10202373, Example 3Z)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(cc(F)c12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C18H17FN4O3S/c1-10-18-17(15(19)9-23(18)27(25,26)13-3-4-13)14(8-21-10)12-5-6-20-16(7-12)22-11(2)24/h5-9,13H,3-4H2,1-2H3,(H,20,22,24)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346208
PNG
(US10202373, Compound I-21 | US10202373, Example 3H)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cncc2n(ccc12)S(C)(=O)=O
Show InChI InChI=1S/C15H14N4O3S/c1-10(20)18-15-7-11(3-5-17-15)13-8-16-9-14-12(13)4-6-19(14)23(2,21)22/h3-9H,1-2H3,(H,17,18,20)
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n/an/a 30n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346215
PNG
(US10202373, Compound I-29 | US10202373, Example 4A)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cncc2n(ccc12)S(C)(=O)=O
Show InChI InChI=1S/C15H14N4O4S/c1-23-15(20)18-14-7-10(3-5-17-14)12-8-16-9-13-11(12)4-6-19(13)24(2,21)22/h3-9H,1-2H3,(H,17,18,20)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346232
PNG
(US10202373, Compound I-46 | US10202373, Example 3Y)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(cc(F)c12)S(C)(=O)=O
Show InChI InChI=1S/C16H15FN4O3S/c1-9-16-15(13(17)8-21(16)25(3,23)24)12(7-19-9)11-4-5-18-14(6-11)20-10(2)22/h4-8H,1-3H3,(H,18,20,22)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346201
PNG
(US10202373, Compound I-13 | US10202373, Example 8)
Show SMILES O=S(=O)(c1ccccc1)n1ccc2c(cncc12)-c1ccnc(Nc2ncco2)c1
Show InChI InChI=1S/C21H15N5O3S/c27-30(28,16-4-2-1-3-5-16)26-10-7-17-18(13-22-14-19(17)26)15-6-8-23-20(12-15)25-21-24-9-11-29-21/h1-14H,(H,23,24,25)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346207
PNG
(US10202373, Compound I-20 | US10202373, Example 3E)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cncc2[nH]ccc12
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n/an/a 75n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346214
PNG
(US10202373, Compound I-28 | US10202373, Example 7)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cncc2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H16N4O4S/c1-28-20(25)23-19-11-14(7-9-22-19)17-12-21-13-18-16(17)8-10-24(18)29(26,27)15-5-3-2-4-6-15/h2-13H,1H3,(H,22,23,25)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346200
PNG
(US10202373, Compound I-12 | US10202373, Example 4G)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)C1CCCC1
Show InChI InChI=1S/C20H22N4O4S/c1-13-19-16(8-10-24(19)29(26,27)15-5-3-4-6-15)17(12-22-13)14-7-9-21-18(11-14)23-20(25)28-2/h7-12,15H,3-6H2,1-2H3,(H,21,23,25)
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MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%