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Patent code US10202375

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Wnt-3a


(Mus musculus)
BDBM346247
PNG
(2-[2-methyl-4-(2-methyl-4-pyridyl)pyrrolo[2,3-d]py...)
Show SMILES Cc1cc(ccn1)-c1nc(C)nc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C24H20N8O/c1-15-11-17(5-7-26-15)23-19-6-10-32(24(19)30-16(2)29-23)14-22(33)31-21-4-3-18(12-28-21)20-13-25-8-9-27-20/h3-13H,14H2,1-2H3,(H,28,31,33)
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Redx Pharma PLC

US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346240
PNG
(2-[5-(2-methyl-4-pyridyl)pyrazolo[3,4-b]pyridin-1-...)
Show SMILES Cc1cc(ccn1)-c1ncnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C23H18N8O/c1-15-10-16(4-6-25-15)22-18-5-9-31(23(18)29-14-28-22)13-21(32)30-20-3-2-17(11-27-20)19-12-24-7-8-26-19/h2-12,14H,13H2,1H3,(H,27,30,32)
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Redx Pharma PLC

US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346260
PNG
(2-[4-(2-methyl-4-pyridyl)pyrrolo[3,2-c]pyridin-1-y...)
Show SMILES Cc1cc(ccn1)-c1nccc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C24H19N7O/c1-16-12-17(4-7-26-16)24-19-6-11-31(21(19)5-8-28-24)15-23(32)30-22-3-2-18(13-29-22)20-14-25-9-10-27-20/h2-14H,15H2,1H3,(H,29,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346238
PNG
(2-[5-methyl-4-(2-methyl-4-pyridyl)pyrrolo[2,3-b]py...)
Show SMILES Cc1cc(ccn1)-c1ccnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C24H19N7O/c1-16-12-17(4-7-26-16)19-5-8-28-24-20(19)6-11-31(24)15-23(32)30-22-3-2-18(13-29-22)21-14-25-9-10-27-21/h2-14H,15H2,1H3,(H,29,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346268
PNG
(2-[4-(2-methylpyrazol-3-yl)pyrrolo[2,3-b]pyridin-1...)
Show SMILES Cn1nccc1-c1ccnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C22H18N8O/c1-29-19(5-8-27-29)16-4-7-25-22-17(16)6-11-30(22)14-21(31)28-20-3-2-15(12-26-20)18-13-23-9-10-24-18/h2-13H,14H2,1H3,(H,26,28,31)
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Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346242
PNG
(2-[5-(2-methyl-4-pyridyl)pyrrolo[2,3-b]pyridin-1-y...)
Show SMILES Cc1cc(ccn1)-c1ccnc2n(CC(=O)Nc3ccc(nc3)-c3cnccn3)ccc12
Show InChI InChI=1S/C24H19N7O/c1-16-12-17(4-7-26-16)19-5-8-28-24-20(19)6-11-31(24)15-23(32)30-18-2-3-21(29-13-18)22-14-25-9-10-27-22/h2-14H,15H2,1H3,(H,30,32)
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Redx Pharma PLC

US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346240
PNG
(2-[5-(2-methyl-4-pyridyl)pyrazolo[3,4-b]pyridin-1-...)
Show SMILES Cc1cc(ccn1)-c1ncnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C23H18N8O/c1-15-10-16(4-6-25-15)22-18-5-9-31(23(18)29-14-28-22)13-21(32)30-20-3-2-17(11-27-20)19-12-24-7-8-26-19/h2-12,14H,13H2,1H3,(H,27,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346245
PNG
(2-[2-amino-4-(2-methyl-4-pyridyl)pyrrolo[2,3-d]pyr...)
Show SMILES Cc1cc(ccn1)-c1nc(N)nc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C23H19N9O/c1-14-10-15(4-6-26-14)21-17-5-9-32(22(17)31-23(24)30-21)13-20(33)29-19-3-2-16(11-28-19)18-12-25-7-8-27-18/h2-12H,13H2,1H3,(H2,24,30,31)(H,28,29,33)
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Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346248
PNG
(2-[4-(2-methylpyrazol-3-yl)pyrazolo[3,4-d]pyrimidi...)
Show SMILES O=C(Cn1ccc2c(ncnc12)N1CCCCC1)Nc1ccc(cn1)-c1cnccn1
Show InChI InChI=1S/C22H22N8O/c31-20(28-19-5-4-16(12-25-19)18-13-23-7-8-24-18)14-30-11-6-17-21(26-15-27-22(17)30)29-9-2-1-3-10-29/h4-8,11-13,15H,1-3,9-10,14H2,(H,25,28,31)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346238
PNG
(2-[5-methyl-4-(2-methyl-4-pyridyl)pyrrolo[2,3-b]py...)
Show SMILES Cc1cc(ccn1)-c1ccnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C24H19N7O/c1-16-12-17(4-7-26-16)19-5-8-28-24-20(19)6-11-31(24)15-23(32)30-22-3-2-18(13-29-22)21-14-25-9-10-27-21/h2-14H,15H2,1H3,(H,29,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346262
PNG
(2-[4-(2-methyl-4-pyridyl)pyrazolo[3,4-b]pyridin-1-...)
Show SMILES Cc1cc(ccn1)-c1ccnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ncc12
Show InChI InChI=1S/C23H18N8O/c1-15-10-16(4-6-25-15)18-5-7-27-23-19(18)12-29-31(23)14-22(32)30-21-3-2-17(11-28-21)20-13-24-8-9-26-20/h2-13H,14H2,1H3,(H,28,30,32)
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Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346239
PNG
(2-[5-fluoro-4-(2-methyl-4-pyridyl)pyrrolo[2,3-b]py...)
Show SMILES Cc1cc(ccn1)-c1c(F)cnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C24H18FN7O/c1-15-10-16(4-6-27-15)23-18-5-9-32(24(18)30-12-19(23)25)14-22(33)31-21-3-2-17(11-29-21)20-13-26-7-8-28-20/h2-13H,14H2,1H3,(H,29,31,33)
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Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346238
PNG
(2-[5-methyl-4-(2-methyl-4-pyridyl)pyrrolo[2,3-b]py...)
Show SMILES Cc1cc(ccn1)-c1ccnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C24H19N7O/c1-16-12-17(4-7-26-16)19-5-8-28-24-20(19)6-11-31(24)15-23(32)30-22-3-2-18(13-29-22)21-14-25-9-10-27-21/h2-14H,15H2,1H3,(H,29,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346249
PNG
(2-[2-chloro-4-(2-methyl-4-pyridyl)pyrrolo[2,3-d]py...)
Show SMILES Cc1cc(ccn1)-c1nc(Cl)nc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C23H17ClN8O/c1-14-10-15(4-6-26-14)21-17-5-9-32(22(17)31-23(24)30-21)13-20(33)29-19-3-2-16(11-28-19)18-12-25-7-8-27-18/h2-12H,13H2,1H3,(H,28,29,33)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346247
PNG
(2-[2-methyl-4-(2-methyl-4-pyridyl)pyrrolo[2,3-d]py...)
Show SMILES Cc1cc(ccn1)-c1nc(C)nc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C24H20N8O/c1-15-11-17(5-7-26-15)23-19-6-10-32(24(19)30-16(2)29-23)14-22(33)31-21-4-3-18(12-28-21)20-13-25-8-9-27-20/h3-13H,14H2,1-2H3,(H,28,31,33)
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Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346239
PNG
(2-[5-fluoro-4-(2-methyl-4-pyridyl)pyrrolo[2,3-b]py...)
Show SMILES Cc1cc(ccn1)-c1c(F)cnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C24H18FN7O/c1-15-10-16(4-6-27-15)23-18-5-9-32(24(18)30-12-19(23)25)14-22(33)31-21-3-2-17(11-29-21)20-13-26-7-8-28-20/h2-13H,14H2,1H3,(H,29,31,33)
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Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346258
PNG
(N-(5-pyrazin-2-yl-2-pyridyl)-2-[4-[2-(trifluoromet...)
Show SMILES FC(F)(F)c1cc(ccn1)-c1ncnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C23H15F3N8O/c24-23(25,26)18-9-14(3-5-29-18)21-16-4-8-34(22(16)32-13-31-21)12-20(35)33-19-2-1-15(10-30-19)17-11-27-6-7-28-17/h1-11,13H,12H2,(H,30,33,35)
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Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346268
PNG
(2-[4-(2-methylpyrazol-3-yl)pyrrolo[2,3-b]pyridin-1...)
Show SMILES Cn1nccc1-c1ccnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C22H18N8O/c1-29-19(5-8-27-29)16-4-7-25-22-17(16)6-11-30(22)14-21(31)28-20-3-2-15(12-26-20)18-13-23-9-10-24-18/h2-13H,14H2,1H3,(H,26,28,31)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346240
PNG
(2-[5-(2-methyl-4-pyridyl)pyrazolo[3,4-b]pyridin-1-...)
Show SMILES Cc1cc(ccn1)-c1ncnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C23H18N8O/c1-15-10-16(4-6-25-15)22-18-5-9-31(23(18)29-14-28-22)13-21(32)30-20-3-2-17(11-27-20)19-12-24-7-8-26-19/h2-12,14H,13H2,1H3,(H,27,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346261
PNG
(2-[4-(2-methyl-4-pyridyl)pyrrolo[2,3-c]pyridin-1-y...)
Show SMILES Cc1cc(ccn1)-c1cncc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C24H19N7O/c1-16-10-17(4-6-27-16)20-12-26-14-22-19(20)5-9-31(22)15-24(32)30-23-3-2-18(11-29-23)21-13-25-7-8-28-21/h2-14H,15H2,1H3,(H,29,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346244
PNG
(2-[4-(2-methylpyrazol-3-yl)pyrrolo[2,3-c]pyridin-1...)
Show SMILES Cc1cc(ccn1)-c1ncnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ncc12
Show InChI InChI=1S/C22H17N9O/c1-14-8-15(4-5-24-14)21-17-10-29-31(22(17)28-13-27-21)12-20(32)30-19-3-2-16(9-26-19)18-11-23-6-7-25-18/h2-11,13H,12H2,1H3,(H,26,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346260
PNG
(2-[4-(2-methyl-4-pyridyl)pyrrolo[3,2-c]pyridin-1-y...)
Show SMILES Cc1cc(ccn1)-c1nccc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C24H19N7O/c1-16-12-17(4-7-26-16)24-19-6-11-31(21(19)5-8-28-24)15-23(32)30-22-3-2-18(13-29-22)20-14-25-9-10-27-20/h2-14H,15H2,1H3,(H,29,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346242
PNG
(2-[5-(2-methyl-4-pyridyl)pyrrolo[2,3-b]pyridin-1-y...)
Show SMILES Cc1cc(ccn1)-c1ccnc2n(CC(=O)Nc3ccc(nc3)-c3cnccn3)ccc12
Show InChI InChI=1S/C24H19N7O/c1-16-12-17(4-7-26-16)19-5-8-28-24-20(19)6-11-31(24)15-23(32)30-18-2-3-21(29-13-18)22-14-25-9-10-27-22/h2-14H,15H2,1H3,(H,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346241
PNG
(2-[4-(2-methylpyrazol-3-yl)pyrrolo[3,2-c]pyridin-1...)
Show SMILES Cn1nccc1-c1nccc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C22H18N8O/c1-29-19(5-8-27-29)22-16-6-11-30(18(16)4-7-25-22)14-21(31)28-20-3-2-15(12-26-20)17-13-23-9-10-24-17/h2-13H,14H2,1H3,(H,26,28,31)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346251
PNG
(2-[4-(2-methyl-4-pyridyl)pyrazolo[3,4-d]pyrimidin-...)
Show SMILES Cc1cc(ccn1)-c1ncnc2n(CC(=O)Nc3ccc(nc3)-c3cnccn3)ncc12
Show InChI InChI=1S/C22H17N9O/c1-14-8-15(4-5-24-14)21-17-10-29-31(22(17)28-13-27-21)12-20(32)30-16-2-3-18(26-9-16)19-11-23-6-7-25-19/h2-11,13H,12H2,1H3,(H,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346267
PNG
(2-[4-(1-piperidyl)pyrrolo[2,3-b]pyridin-1-yl]-N-(5...)
Show SMILES O=C(Cn1ccc2c(ccnc12)N1CCCCC1)Nc1ccc(cn1)-c1cnccn1
Show InChI InChI=1S/C23H23N7O/c31-22(28-21-5-4-17(14-27-21)19-15-24-9-10-25-19)16-30-13-7-18-20(6-8-26-23(18)30)29-11-2-1-3-12-29/h4-10,13-15H,1-3,11-12,16H2,(H,27,28,31)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346244
PNG
(2-[4-(2-methylpyrazol-3-yl)pyrrolo[2,3-c]pyridin-1...)
Show SMILES Cc1cc(ccn1)-c1ncnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ncc12
Show InChI InChI=1S/C22H17N9O/c1-14-8-15(4-5-24-14)21-17-10-29-31(22(17)28-13-27-21)12-20(32)30-19-3-2-16(9-26-19)18-11-23-6-7-25-18/h2-11,13H,12H2,1H3,(H,26,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346252
PNG
(2-[4-(2-methyl-4-pyridyl)pyrazolo[3,4-b]pyridin-1-...)
Show SMILES Cc1cc(ccn1)-c1ccnc2n(CC(=O)Nc3ccc(nc3)-c3cnccn3)ncc12
Show InChI InChI=1S/C23H18N8O/c1-15-10-16(4-6-25-15)18-5-7-27-23-19(18)12-29-31(23)14-22(32)30-17-2-3-20(28-11-17)21-13-24-8-9-26-21/h2-13H,14H2,1H3,(H,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346255
PNG
(2-[4-(2-methylpyrazol-3-yl)pyrrolo[2,3-d]pyrimidin...)
Show SMILES Cn1nccc1-c1ncnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C21H17N9O/c1-29-17(4-6-27-29)20-15-5-9-30(21(15)26-13-25-20)12-19(31)28-18-3-2-14(10-24-18)16-11-22-7-8-23-16/h2-11,13H,12H2,1H3,(H,24,28,31)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346257
PNG
(2-[4-(2-methyl-4-pyridyl)imidazo[4,5-c]pyridin-1-y...)
Show SMILES Cc1cc(ccn1)-c1nccc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)cnc12
Show InChI InChI=1S/C23H18N8O/c1-15-10-16(4-6-25-15)22-23-19(5-7-27-22)31(14-29-23)13-21(32)30-20-3-2-17(11-28-20)18-12-24-8-9-26-18/h2-12,14H,13H2,1H3,(H,28,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346250
PNG
(2-[6-methyl-4-(2-methyl-4-pyridyl)pyrrolo[2,3-d]py...)
Show SMILES Cc1cc2c(ncnc2n1CC(=O)Nc1ccc(cn1)-c1cnccn1)-c1ccnc(C)c1
Show InChI InChI=1S/C24H20N8O/c1-15-9-17(5-6-26-15)23-19-10-16(2)32(24(19)30-14-29-23)13-22(33)31-21-4-3-18(11-28-21)20-12-25-7-8-27-20/h3-12,14H,13H2,1-2H3,(H,28,31,33)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346243
PNG
(2-[4-(2-methylpyrazol-3-yl)pyrazolo[3,4-b]pyridin-...)
Show SMILES Cn1nccc1-c1ccnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ncc12
Show InChI InChI=1S/C21H17N9O/c1-29-18(5-7-26-29)15-4-6-24-21-16(15)11-27-30(21)13-20(31)28-19-3-2-14(10-25-19)17-12-22-8-9-23-17/h2-12H,13H2,1H3,(H,25,28,31)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346265
PNG
(2-[4-(4-methylpiperazin-1-yl)pyrrolo[2,3-b]pyridin...)
Show SMILES CN1CCN(CC1)c1ccnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C23H24N8O/c1-29-10-12-30(13-11-29)20-4-6-26-23-18(20)5-9-31(23)16-22(32)28-21-3-2-17(14-27-21)19-15-24-7-8-25-19/h2-9,14-15H,10-13,16H2,1H3,(H,27,28,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346266
PNG
(2-[4-(3,5-dimethylpiperazin-1-yl)pyrrolo[2,3-b]pyr...)
Show SMILES CC1CN(CC(C)N1)c1ccnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1/C24H26N8O/c1-16-13-32(14-17(2)29-16)21-5-7-27-24-19(21)6-10-31(24)15-23(33)30-22-4-3-18(11-28-22)20-12-25-8-9-26-20/h3-12,16-17,29H,13-15H2,1-2H3,(H,28,30,33)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346256
PNG
(2-[6-(2-methyl-4-pyridyl)purin-9-yl]-N-(5-pyrazin-...)
Show SMILES Cc1cc(ccn1)-c1ncnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)cnc12
Show InChI InChI=1S/C22H17N9O/c1-14-8-15(4-5-24-14)20-21-22(28-12-27-20)31(13-29-21)11-19(32)30-18-3-2-16(9-26-18)17-10-23-6-7-25-17/h2-10,12-13H,11H2,1H3,(H,26,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM346253
PNG
(2-[4-(2-methyl-4-pyridyl)pyrrolo[2,3-d]pyrimidin-7...)
Show SMILES Cc1cc(ccn1)-c1ncnc2n(CC(=O)Nc3ccc(nc3)-c3cnccn3)ccc12
Show InChI InChI=1S/C23H18N8O/c1-15-10-16(4-6-25-15)22-18-5-9-31(23(18)29-14-28-22)13-21(32)30-17-2-3-19(27-11-17)20-12-24-7-8-26-20/h2-12,14H,13H2,1H3,(H,30,32)
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US Patent


Assay Description
Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T...


US Patent US10202375 (2019)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q29W0HMN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%