BindingDB logo
myBDB logout

Patent code US10202377

Compile Data Set for Download or QSAR

Found 207 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346341
PNG
(US10202377, Compound 367)
Show SMILES Cc1ccc(s1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cncc(N)c1
Show InChI InChI=1S/C23H15N7S/c1-12-5-6-20(31-12)15-3-2-4-17-21(15)28-23(27-17)22-16-8-18(26-11-19(16)29-30-22)13-7-14(24)10-25-9-13/h2-11H,24H2,1H3/b23-22+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.5n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346315
PNG
(US10202377, Compound 269)
Show SMILES CC(C)C(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccsc1
Show InChI InChI=1S/C26H19N7OS/c1-14(2)26(34)29-17-8-16(10-27-11-17)21-9-19-22(12-28-21)32-33-24(19)25-30-20-5-3-4-18(23(20)31-25)15-6-7-35-13-15/h3-14H,1-2H3,(H,29,34)/b25-24+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.20n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346283
PNG
(US10202377, Compound 82)
Show SMILES c1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccnc1
Show InChI InChI=1S/C23H13N7/c1-6-16(14-4-2-8-24-11-14)21-18(7-1)27-23(28-21)22-17-10-19(15-5-3-9-25-12-15)26-13-20(17)29-30-22/h1-13H/b23-22+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346318
PNG
(US10202377, Compound 280)
Show SMILES O=C(Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccsc1)C1CCC1
Show InChI InChI=1S/C27H19N7OS/c35-27(15-3-1-4-15)30-18-9-17(11-28-12-18)22-10-20-23(13-29-22)33-34-25(20)26-31-21-6-2-5-19(24(21)32-26)16-7-8-36-14-16/h2,5-15H,1,3-4H2,(H,30,35)/b26-25+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.20n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346320
PNG
(US10202377, Compound 288)
Show SMILES CC(C)CC(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccoc1
Show InChI InChI=1S/C27H21N7O2/c1-15(2)8-24(35)30-18-9-17(11-28-12-18)22-10-20-23(13-29-22)33-34-26(20)27-31-21-5-3-4-19(25(21)32-27)16-6-7-36-14-16/h3-7,9-15H,8H2,1-2H3,(H,30,35)/b27-26+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.80n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346309
PNG
(US10202377, Compound 238)
Show SMILES c1ccc2[nH]c(nc2c1)-c1n[nH]c2cnc(cc12)-c1cccnc1
Show InChI InChI=1S/C18H10N6/c1-2-6-14-13(5-1)21-18(22-14)17-12-8-15(11-4-3-7-19-9-11)20-10-16(12)23-24-17/h1-10H
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.70n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346351
PNG
(US10202377, Compound 421)
Show SMILES Cc1ccncc1-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cc(F)cc(CNS(C)(=O)=O)c1
Show InChI InChI=1S/C27H20FN7O2S/c1-15-6-7-29-13-21(15)23-11-20-24(14-30-23)34-35-26(20)27-32-22-5-3-4-19(25(22)33-27)17-8-16(9-18(28)10-17)12-31-38(2,36)37/h3-11,13-14,31H,12H2,1-2H3/b27-26+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346339
PNG
(US10202377, Compound 358)
Show SMILES Fc1ccc(s1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cncc(NC(=O)C2CCC2)c1
Show InChI InChI=1S/C27H18FN7OS/c28-23-8-7-22(37-23)17-5-2-6-19-24(17)33-26(32-19)25-18-10-20(30-13-21(18)34-35-25)15-9-16(12-29-11-15)31-27(36)14-3-1-4-14/h2,5-14H,1,3-4H2,(H,31,36)/b26-25+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11.6n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346324
PNG
(US10202377, Compound 298)
Show SMILES CC(C)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccoc1
Show InChI InChI=1S/C25H19N7O/c1-14(2)28-17-8-16(10-26-11-17)21-9-19-22(12-27-21)31-32-24(19)25-29-20-5-3-4-18(23(20)30-25)15-6-7-33-13-15/h3-14,28H,1-2H3/b25-24+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12.9n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346285
PNG
(US10202377, Compound 90)
Show SMILES CC(C)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccnc1
Show InChI InChI=1S/C26H20N8/c1-15(2)30-18-9-17(12-28-13-18)22-10-20-23(14-29-22)33-34-25(20)26-31-21-7-3-6-19(24(21)32-26)16-5-4-8-27-11-16/h3-15,30H,1-2H3/b26-25+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13.9n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346332
PNG
(US10202377, Compound 321)
Show SMILES CC(C)C(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccs1
Show InChI InChI=1S/C26H19N7OS/c1-14(2)26(34)29-16-9-15(11-27-12-16)20-10-18-21(13-28-20)32-33-24(18)25-30-19-6-3-5-17(23(19)31-25)22-7-4-8-35-22/h3-14H,1-2H3,(H,29,34)/b25-24+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16.3n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346326
PNG
(US10202377, Compound 306)
Show SMILES O=C(Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccoc1)C1CCC1
Show InChI InChI=1S/C27H19N7O2/c35-27(15-3-1-4-15)30-18-9-17(11-28-12-18)22-10-20-23(13-29-22)33-34-25(20)26-31-21-6-2-5-19(24(21)32-26)16-7-8-36-14-16/h2,5-15H,1,3-4H2,(H,30,35)/b26-25+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16.8n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346335
PNG
(US10202377, Compound 331)
Show SMILES O=C(Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccs1)C1CC1
Show InChI InChI=1S/C26H17N7OS/c34-26(14-6-7-14)29-16-9-15(11-27-12-16)20-10-18-21(13-28-20)32-33-24(18)25-30-19-4-1-3-17(23(19)31-25)22-5-2-8-35-22/h1-5,8-14H,6-7H2,(H,29,34)/b25-24+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 17.2n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346337
PNG
(US10202377, Compound 340)
Show SMILES CC(C)CC(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccc(F)s1
Show InChI InChI=1S/C27H20FN7OS/c1-14(2)8-24(36)31-16-9-15(11-29-12-16)20-10-18-21(13-30-20)34-35-26(18)27-32-19-5-3-4-17(25(19)33-27)22-6-7-23(28)37-22/h3-7,9-14H,8H2,1-2H3,(H,31,36)/b27-26+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 17.3n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346271
PNG
(US10202377, Compound 13)
Show SMILES CN(C)Cc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccc(F)c1
Show InChI InChI=1S/C27H20FN7/c1-35(2)15-16-9-18(13-29-12-16)23-11-21-24(14-30-23)33-34-26(21)27-31-22-8-4-7-20(25(22)32-27)17-5-3-6-19(28)10-17/h3-14H,15H2,1-2H3/b27-26+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 19.1n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346313
PNG
(US10202377, Compound 265)
Show SMILES Cc1ccncc1-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccsc1
Show InChI InChI=1S/C23H14N6S/c1-13-5-7-24-10-17(13)19-9-16-20(11-25-19)28-29-22(16)23-26-18-4-2-3-15(21(18)27-23)14-6-8-30-12-14/h2-12H,1H3/b23-22+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 19.4n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346279
PNG
(US10202377, Compound 55)
Show SMILES Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccccc1F
Show InChI InChI=1S/C24H14FN7/c25-18-6-2-1-4-15(18)16-5-3-7-19-22(16)30-24(29-19)23-17-9-20(28-12-21(17)31-32-23)13-8-14(26)11-27-10-13/h1-12H,26H2/b24-23+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 19.5n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346352
PNG
(US10202377, Compound 424)
Show SMILES CC(C)(C)C(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cc(F)cc(CNS(C)(=O)=O)c1
Show InChI InChI=1S/C31H27FN8O3S/c1-31(2,3)30(41)36-21-11-19(14-33-15-21)25-12-23-26(16-34-25)39-40-28(23)29-37-24-7-5-6-22(27(24)38-29)18-8-17(9-20(32)10-18)13-35-44(4,42)43/h5-12,14-16,35H,13H2,1-4H3,(H,36,41)/b29-28+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 19.9n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346344
PNG
(US10202377, Compound 381)
Show SMILES CCCC(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccc(C)s1
Show InChI InChI=1S/C27H21N7OS/c1-3-5-24(35)30-17-10-16(12-28-13-17)21-11-19-22(14-29-21)33-34-26(19)27-31-20-7-4-6-18(25(20)32-27)23-9-8-15(2)36-23/h4,6-14H,3,5H2,1-2H3,(H,30,35)/b27-26+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 21.5n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346365
PNG
(US10202377, Compound 939)
Show SMILES Fc1cccc(c1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cn[nH]c1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346355
PNG
(US10202377, Compound 436)
Show SMILES CS(=O)(=O)NCc1cc(F)cc(c1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cncc(NC(=O)C2CCC2)c1
Show InChI InChI=1S/C31H25FN8O3S/c1-44(42,43)35-13-17-8-19(10-21(32)9-17)23-6-3-7-25-28(23)38-30(37-25)29-24-12-26(34-16-27(24)39-40-29)20-11-22(15-33-14-20)36-31(41)18-4-2-5-18/h3,6-12,14-16,18,35H,2,4-5,13H2,1H3,(H,36,41)/b30-29+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 25.8n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346357
PNG
(US10202377, Compound 442)
Show SMILES CS(=O)(=O)NCc1cc(F)cc(c1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cncnc1
Show InChI InChI=1S/C25H17FN8O2S/c1-37(35,36)30-9-14-5-15(7-17(26)6-14)18-3-2-4-20-23(18)32-25(31-20)24-19-8-21(16-10-27-13-28-11-16)29-12-22(19)33-34-24/h2-8,10-13,30H,9H2,1H3/b25-24+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 26n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346333
PNG
(US10202377, Compound 325)
Show SMILES CN(C)Cc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccs1
Show InChI InChI=1S/C25H19N7S/c1-32(2)14-15-9-16(12-26-11-15)20-10-18-21(13-27-20)30-31-24(18)25-28-19-6-3-5-17(23(19)29-25)22-7-4-8-33-22/h3-13H,14H2,1-2H3/b25-24+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 26.7n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346296
PNG
(US10202377, Compound 169)
Show SMILES CN(C)Cc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)N1CCCCC1
Show InChI InChI=1S/C26H26N8/c1-33(2)16-17-11-18(14-27-13-17)21-12-19-22(15-28-21)31-32-24(19)26-29-20-7-6-8-23(25(20)30-26)34-9-4-3-5-10-34/h6-8,11-15H,3-5,9-10,16H2,1-2H3/b26-24+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 28.3n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346354
PNG
(US10202377, Compound 433)
Show SMILES CCCC(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cc(F)cc(CNS(C)(=O)=O)c1
Show InChI InChI=1S/C30H25FN8O3S/c1-3-5-27(40)35-21-11-19(14-32-15-21)25-12-23-26(16-33-25)38-39-29(23)30-36-24-7-4-6-22(28(24)37-30)18-8-17(9-20(31)10-18)13-34-43(2,41)42/h4,6-12,14-16,34H,3,5,13H2,1-2H3,(H,35,40)/b30-29+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 28.5n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346375
PNG
(US10202377, Compound 949)
Show SMILES Oc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccc(F)c1
Show InChI InChI=1S/C24H13FN6O/c25-15-4-1-3-13(7-15)17-5-2-6-19-22(17)29-24(28-19)23-18-9-20(27-12-21(18)30-31-23)14-8-16(32)11-26-10-14/h1-12,32H/b24-23+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 29n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346321
PNG
(US10202377, Compound 292)
Show SMILES CCNCc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccoc1
Show InChI InChI=1S/C25H19N7O/c1-2-26-10-15-8-17(12-27-11-15)21-9-19-22(13-28-21)31-32-24(19)25-29-20-5-3-4-18(23(20)30-25)16-6-7-33-14-16/h3-9,11-14,26H,2,10H2,1H3/b25-24+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 29.6n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346338
PNG
(US10202377, Compound 352)
Show SMILES Fc1ccc(s1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cncc(CN2CCCC2)c1
Show InChI InChI=1S/C27H20FN7S/c28-24-7-6-23(36-24)18-4-3-5-20-25(18)32-27(31-20)26-19-11-21(30-14-22(19)33-34-26)17-10-16(12-29-13-17)15-35-8-1-2-9-35/h3-7,10-14H,1-2,8-9,15H2/b27-26+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 30.5n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346319
PNG
(US10202377, Compound 283)
Show SMILES C(NCc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccsc1)c1ccccc1
Show InChI InChI=1S/C30H21N7S/c1-2-5-19(6-3-1)13-31-14-20-11-22(16-32-15-20)26-12-24-27(17-33-26)36-37-29(24)30-34-25-8-4-7-23(28(25)35-30)21-9-10-38-18-21/h1-12,15-18,31H,13-14H2/b30-29+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 30.9n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346340
PNG
(US10202377, Compound 366)
Show SMILES CC(C)CC(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccc(C)s1
Show InChI InChI=1S/C28H23N7OS/c1-15(2)9-25(36)31-18-10-17(12-29-13-18)22-11-20-23(14-30-22)34-35-27(20)28-32-21-6-4-5-19(26(21)33-28)24-8-7-16(3)37-24/h4-8,10-15H,9H2,1-3H3,(H,31,36)/b28-27+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 31.1n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346275
PNG
(US10202377, Compound 34)
Show SMILES CC(C)(C)C(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H22FN7O/c1-29(2,3)28(38)33-19-11-17(13-31-14-19)23-12-21-24(15-32-23)36-37-26(21)27-34-22-6-4-5-20(25(22)35-27)16-7-9-18(30)10-8-16/h4-15H,1-3H3,(H,33,38)/b27-26+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 31.2n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346346
PNG
(US10202377, Compound 392)
Show SMILES CC(C)CC(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccc(s1)C(C)=O
Show InChI InChI=1S/C29H23N7O2S/c1-15(2)9-26(38)32-18-10-17(12-30-13-18)22-11-20-23(14-31-22)35-36-28(20)29-33-21-6-4-5-19(27(21)34-29)25-8-7-24(39-25)16(3)37/h4-8,10-15H,9H2,1-3H3,(H,32,38)/b29-28+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 32.1n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346342
PNG
(US10202377, Compound 373)
Show SMILES CC(C)C(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccc(C)s1
Show InChI InChI=1S/C27H21N7OS/c1-14(2)27(35)30-17-9-16(11-28-12-17)21-10-19-22(13-29-21)33-34-25(19)26-31-20-6-4-5-18(24(20)32-26)23-8-7-15(3)36-23/h4-14H,1-3H3,(H,30,35)/b26-25+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 32.6n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346374
PNG
(US10202377, Compound 948)
Show SMILES COc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccc(F)c1
Show InChI InChI=1S/C25H15FN6O/c1-33-17-9-15(11-27-12-17)21-10-19-22(13-28-21)31-32-24(19)25-29-20-7-3-6-18(23(20)30-25)14-4-2-5-16(26)8-14/h2-13H,1H3/b25-24+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 33n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346345
PNG
(US10202377, Compound 385)
Show SMILES Cc1ccc(s1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cncc(NC(=O)C2CCCC2)c1
Show InChI InChI=1S/C29H23N7OS/c1-16-9-10-25(38-16)20-7-4-8-22-26(20)34-28(33-22)27-21-12-23(31-15-24(21)35-36-27)18-11-19(14-30-13-18)32-29(37)17-5-2-3-6-17/h4,7-15,17H,2-3,5-6H2,1H3,(H,32,37)/b28-27+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 33.1n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346323
PNG
(US10202377, Compound 295)
Show SMILES CC(C)C(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccoc1
Show InChI InChI=1S/C26H19N7O2/c1-14(2)26(34)29-17-8-16(10-27-11-17)21-9-19-22(12-28-21)32-33-24(19)25-30-20-5-3-4-18(23(20)31-25)15-6-7-35-13-15/h3-14H,1-2H3,(H,29,34)/b25-24+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.3n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346356
PNG
(US10202377, Compound 439)
Show SMILES CS(=O)(=O)NCc1cc(F)cc(c1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cncc(CNCc2ccccc2)c1
Show InChI InChI=1S/C34H27FN8O2S/c1-46(44,45)39-18-22-10-24(13-26(35)12-22)27-8-5-9-29-32(27)41-34(40-29)33-28-14-30(38-20-31(28)42-43-33)25-11-23(17-37-19-25)16-36-15-21-6-3-2-4-7-21/h2-14,17,19-20,36,39H,15-16,18H2,1H3/b34-33+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 40.1n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346348
PNG
(US10202377, Compound 400)
Show SMILES CC(=O)c1ccc(s1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cncc(NC(=O)Cc2ccccc2)c1
Show InChI InChI=1S/C32H21N7O2S/c1-18(40)27-10-11-28(42-27)22-8-5-9-24-30(22)37-32(36-24)31-23-14-25(34-17-26(23)38-39-31)20-13-21(16-33-15-20)35-29(41)12-19-6-3-2-4-7-19/h2-11,13-17H,12H2,1H3,(H,35,41)/b32-31+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 42.3n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346270
PNG
(US10202377, Compound 7)
Show SMILES CN(C)c1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccc(F)c1
Show InChI InChI=1S/C26H18FN7/c1-34(2)18-10-16(12-28-13-18)22-11-20-23(14-29-22)32-33-25(20)26-30-21-8-4-7-19(24(21)31-26)15-5-3-6-17(27)9-15/h3-14H,1-2H3/b26-25+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 42.4n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346288
PNG
(US10202377, Compound 109)
Show SMILES Cc1ccncc1-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccncc1
Show InChI InChI=1S/C24H15N7/c1-14-5-8-26-12-18(14)20-11-17-21(13-27-20)30-31-23(17)24-28-19-4-2-3-16(22(19)29-24)15-6-9-25-10-7-15/h2-13H,1H3/b24-23+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 42.5n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346317
PNG
(US10202377, Compound 277)
Show SMILES CCCC(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccsc1
Show InChI InChI=1S/C26H19N7OS/c1-2-4-23(34)29-17-9-16(11-27-12-17)21-10-19-22(13-28-21)32-33-25(19)26-30-20-6-3-5-18(24(20)31-26)15-7-8-35-14-15/h3,5-14H,2,4H2,1H3,(H,29,34)/b26-25+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 43.5n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346269
PNG
(US10202377, Compound 1)
Show SMILES CCC(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccc(F)c1
Show InChI InChI=1S/C27H18FN7O/c1-2-24(36)31-18-10-16(12-29-13-18)22-11-20-23(14-30-22)34-35-26(20)27-32-21-8-4-7-19(25(21)33-27)15-5-3-6-17(28)9-15/h3-14H,2H2,1H3,(H,31,36)/b27-26+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 43.9n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346347
PNG
(US10202377, Compound 394)
Show SMILES CC(=O)c1ccc(s1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H14N6OS/c1-13(31)20-7-8-21(32-20)15-5-2-6-17-22(15)28-24(27-17)23-16-10-18(14-4-3-9-25-11-14)26-12-19(16)29-30-23/h2-12H,1H3/b24-23+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 44.3n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346380
PNG
(US10202377, Compound 954)
Show SMILES Fc1cccc(c1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cnccn1
Show InChI InChI=1S/C23H12FN7/c24-14-4-1-3-13(9-14)15-5-2-6-17-21(15)29-23(28-17)22-16-10-18(20-11-25-7-8-26-20)27-12-19(16)30-31-22/h1-12H/b23-22+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 45n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346284
PNG
(US10202377, Compound 87)
Show SMILES CC(C)C(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccnc1
Show InChI InChI=1S/C27H20N8O/c1-15(2)27(36)31-18-9-17(12-29-13-18)22-10-20-23(14-30-22)34-35-25(20)26-32-21-7-3-6-19(24(21)33-26)16-5-4-8-28-11-16/h3-15H,1-2H3,(H,31,36)/b26-25+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 45.4n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346366
PNG
(US10202377, Compound 940)
Show SMILES Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccc(F)c1
Show InChI InChI=1S/C23H14FN7/c1-31-12-14(10-26-31)19-9-17-20(11-25-19)29-30-22(17)23-27-18-7-3-6-16(21(18)28-23)13-4-2-5-15(24)8-13/h2-12H,1H3/b23-22+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346322
PNG
(US10202377, Compound 294)
Show SMILES CC(C)(C)C(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccoc1
Show InChI InChI=1S/C27H21N7O2/c1-27(2,3)26(35)30-17-9-16(11-28-12-17)21-10-19-22(13-29-21)33-34-24(19)25-31-20-6-4-5-18(23(20)32-25)15-7-8-36-14-15/h4-14H,1-3H3,(H,30,35)/b25-24+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 48.6n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346277
PNG
(US10202377, Compound 46)
Show SMILES Fc1ccc(cc1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cncc(NC(=O)C2CCC2)c1
Show InChI InChI=1S/C29H20FN7O/c30-19-9-7-16(8-10-19)21-5-2-6-23-26(21)35-28(34-23)27-22-12-24(32-15-25(22)36-37-27)18-11-20(14-31-13-18)33-29(38)17-3-1-4-17/h2,5-15,17H,1,3-4H2,(H,33,38)/b28-27+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 48.9n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346360
PNG
(US10202377, Compound 454)
Show SMILES CC(C)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cc(F)cc(NCCN(C)C)c1
Show InChI InChI=1S/C31H30FN9/c1-18(2)36-23-12-20(15-33-16-23)27-14-25-28(17-35-27)39-40-30(25)31-37-26-7-5-6-24(29(26)38-31)19-10-21(32)13-22(11-19)34-8-9-41(3)4/h5-7,10-18,34,36H,8-9H2,1-4H3/b31-30+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 51.6n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))
BDBM346378
PNG
(US10202377, Compound 952)
Show SMILES Fc1cccc(c1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1ccncc1
Show InChI InChI=1S/C24H13FN6/c25-16-4-1-3-15(11-16)17-5-2-6-19-22(17)29-24(28-19)23-18-12-20(14-7-9-26-10-8-14)27-13-21(18)30-31-23/h1-13H/b24-23+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 53n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...


US Patent US10202377 (2019)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 207 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%