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Patent code US10202378

Compile Data Set for Download or QSAR

Found 434 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346431
PNG
(US10202378, Example 44 | ethyl 2,6-dimethyl-7-oxo-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1cccc(c1)-c1cc[nH]n1)C(F)(F)F
PDB

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US Patent
n/an/a 17n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346545
PNG
(2-methylbutyl 4-(3-hydroxy-3-methyl-but-1-ynyl)-2,...)
Show SMILES CCC(C)COC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(C)O
PDB

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US Patent
n/an/a 19.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346540
PNG
((1-acetyl-4-piperidyl)methyl4-(3-hydroxy-3-methyl-...)
Show SMILES CC(=O)N1CCC(COC(=O)c2c(C)[nH]c3c2c(cn(C)c3=O)C#CC(C)(C)O)CC1
PDB

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US Patent
n/an/a 20.1n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346476
PNG
(US10202378, Example 89 | US10202378, Example 93a |...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(C(F)F)c1ccccc1
PDB

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US Patent
n/an/a 21.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346428
PNG
(US10202378, Example 41 | ethyl 2,6-dimethyl-7-oxo-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1cccc(c1)-c1cn[nH]c1)C(F)(F)F
PDB

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US Patent
n/an/a 21.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346517
PNG
(US10202378, Example 121 | o-tolylmethyl 4-(3-hydro...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1C)c(cn(C)c2=O)C#CC(C)(C)O
PDB

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n/an/a 21.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346561
PNG
((3-amino-1,1-dimethyl-propyl) 4-(3-hydroxy-3-methy...)
Show SMILES Cc1[nH]c2c(c1C(=O)OC(C)(C)CCN)c(cn(C)c2=O)C#CC(C)(C)O
PDB

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US Patent
n/an/a 21.7n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346405
PNG
(US10202378, Example 20 | ethyl 4-[2-(1-hydroxycycl...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC1(O)CCCC1
PDB

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US Patent
n/an/a 21.9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346467
PNG
(US10202378, Example 80 | ethyl 4-(3-hydroxy-3-phen...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)c1ccccc1
PDB

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US Patent
n/an/a 22.6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346549
PNG
(US10202378, Example 153 | cyclohexylmethyl 4-(3-hy...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCC1CCCCC1)c(cn(C)c2=O)C#CC(C)(C)O
PDB

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US Patent
n/an/a 22.6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346544
PNG
(US10202378, Example 148 | cyclopentylmethyl 4-(3-h...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCC1CCCC1)c(cn(C)c2=O)C#CC(C)(C)O
PDB

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US Patent
n/an/a 23.7n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346509
PNG
((2-methoxyphenyl)methyl-4-(3-hydroxy-3-methyl-but-...)
Show SMILES COc1ccccc1COC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(C)O
PDB

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n/an/a 24n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346515
PNG
((2-fluorophenyl)methyl 4-(3-hydroxy-3-methyl-but-1...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1F)c(cn(C)c2=O)C#CC(C)(C)O
PDB

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US Patent
n/an/a 26.7n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346530
PNG
((2-cyano-1,1-dimethyl-ethyl)-4-(3-cyclopropyl-3-hy...)
Show SMILES Cc1[nH]c2c(c1C(=O)OC(C)(C)CC#N)c(cn(C)c2=O)C#CC(C)(O)C1CC1
PDB

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US Patent
n/an/a 26.8n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346496
PNG
(US10202378, Example 100 | ethyl 2,6-dimethyl-7-oxo...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1cccc(c1)-c1cccnc1)C(F)(F)F
PDB

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US Patent
n/an/a 27.3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346559
PNG
((2-cyano-1,1-dimethyl-ethyl)4-(3-hydroxy-3-methyl-...)
Show SMILES Cc1[nH]c2c(c1C(=O)OC(C)(C)CC#N)c(cn(C)c2=O)C#CC(C)(C)O
PDB

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PC sid
UniChem
US Patent
n/an/a 27.3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346484
PNG
(3-(5-isopropyl-1,3,4-oxadiazol-2-yl)-2,6-dimethyl-...)
Show SMILES CC(C)c1nnc(o1)-c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1ccccc1)C(F)(F)F
PDB

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US Patent
n/an/a 27.6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346512
PNG
(US10202378, Example 116 | [2-(trifluoromethyl)phen...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1C(F)(F)F)c(cn(C)c2=O)C#CC(C)(C)O
PDB

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PC sid
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US Patent
n/an/a 27.7n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346575
PNG
(4-(3-cyclopropyl-3-hydroxy-but-1-ynyl)-3-(5-isobut...)
Show SMILES CC(C)Cc1nnc(o1)-c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)C1CC1
PDB

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PC sid
UniChem
US Patent
n/an/a 29.2n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346591
PNG
(4-(3-hydroxy-3-methyl-but-1-ynyl)-3-(5-isopropyl-1...)
Show SMILES CC(C)c1nnc(o1)-c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(C)O
PDB

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PC sid
UniChem
US Patent
n/an/a 29.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346506
PNG
((2-cyanophenyl)methyl 4-(3-hydroxy-3-methyl-but-1-...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1C#N)c(cn(C)c2=O)C#CC(C)(C)O
PDB

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PC sid
UniChem
US Patent
n/an/a 29.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346528
PNG
(US10202378, Example 132 | isobutyl 4-(3-hydroxy-3-...)
Show SMILES CC(C)COC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(C)O
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 29.9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346404
PNG
(US10202378, Example 19 | ethyl 4-[3-(3-cyanophenyl...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)c1cccc(c1)C#N
PDB

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PC sid
UniChem
US Patent
n/an/a 30.3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346546
PNG
(2,2-dimethylpropyl 4-(3-hydroxy-3-methyl-but-1-yny...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCC(C)(C)C)c(cn(C)c2=O)C#CC(C)(C)O
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 30.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346490
PNG
(4-(3-cyclopropyl-3-hydroxy-but-1-ynyl)-3-[5-[(dime...)
Show SMILES CN(C)Cc1nnc(o1)-c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)C1CC1
PDB

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PC sid
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US Patent
n/an/a 30.8n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346529
PNG
(US10202378, Example 133 | tert-butyl 4-(3-hydroxy-...)
Show SMILES Cc1[nH]c2c(c1C(=O)OC(C)(C)C)c(cn(C)c2=O)C#CC(C)(C)O
PDB

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PC sid
UniChem
US Patent
n/an/a 31.1n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346562
PNG
(2-cyanoethyl 2,6-dimethyl-7-oxo-4-(4,4,4-trifluoro...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCCC#N)c(cn(C)c2=O)C#CC(O)(c1ccccc1)C(F)(F)F
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 31.2n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346556
PNG
(US10202378, Example 160 | isobutyl 4-(3-hydroxy-3-...)
Show SMILES CC(C)COC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)c1ccccc1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 32.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346476
PNG
(US10202378, Example 89 | US10202378, Example 93a |...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(C(F)F)c1ccccc1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 32.9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346464
PNG
(US10202378, Example 77 | US10202378, Example 92a |...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)C1CC1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 33.2n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346492
PNG
(3-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-4-(3-cyclopr...)
Show SMILES Cc1[nH]c2c(c1-c1nnc(o1)C(C)(C)C)c(cn(C)c2=O)C#CC(C)(O)C1CC1
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n/an/a 33.9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346592
PNG
(US10202378, Example 197 | ethyl 4-[3-(3-carbamoylp...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1cccc(c1)C(N)=O)C(F)(F)F
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n/an/a 34.1n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346511
PNG
(2-pyridylmethyl 4-(3-hydroxy-3-methyl-but-1-ynyl)-...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccn1)c(cn(C)c2=O)C#CC(C)(C)O
PDB

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n/an/a 34.1n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346499
PNG
(Benzyl 4-(3-hydroxy-3-methyl-but-1-ynyl)-2,6-dimet...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1)c(cn(C)c2=O)C#CC(C)(C)O
PDB

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n/an/a 34.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346501
PNG
(8-quinolylmethyl 4-(3-cyclopropyl-3-hydroxy-but-1-...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1cccc3cccnc13)c(cn(C)c2=O)C#CC(C)(O)C1CC1
PDB

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n/an/a 34.6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346547
PNG
(1,1-dimethylpropyl 4-(3-hydroxy-3-methyl-but-1-yny...)
Show SMILES CCC(C)(C)OC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(C)O
PDB

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n/an/a 35.1n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346430
PNG
(US10202378, Example 43 | ethyl 2,6-dimethyl-7-oxo-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1cccc(CO)c1)C(F)(F)F
PDB

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n/an/a 35.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346587
PNG
(4-(3-cyclopropyl-3-hydroxy-but-1-ynyl)-3-(5-isopro...)
Show SMILES CC(C)c1nnc(o1)-c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)C1CC1
PDB

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n/an/a 36.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346532
PNG
((2-cyano-1,1-dimethyl-ethyl)2,6-dimethyl-7-oxo-4-(...)
Show SMILES Cc1[nH]c2c(c1C(=O)OC(C)(C)CC#N)c(cn(C)c2=O)C#CC(O)(c1ccccc1)C(F)(F)F
PDB

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n/an/a 36.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346555
PNG
(US10202378, Example 159 | cyclohexyl 4-(3-hydroxy-...)
Show SMILES Cc1[nH]c2c(c1C(=O)OC1CCCCC1)c(cn(C)c2=O)C#CC(C)(C)O
PDB

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n/an/a 36.9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346502
PNG
(US10202378, Example 106 | [3-(hydroxymethyl)phenyl...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1cccc(CO)c1)c(cn(C)c2=O)C#CC(C)(O)C1CC1
PDB

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n/an/a 37.2n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346536
PNG
(3-acetamidopropyl 4-(3-cyclopropyl-3-hydroxy-but-1...)
Show SMILES CC(=O)NCCCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)C1CC1
PDB

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n/an/a 37.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346507
PNG
(US10202378, Example 111 | [2-(hydroxymethyl)phenyl...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1CO)c(cn(C)c2=O)C#CC(C)(C)O
PDB

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n/an/a 37.9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346447
PNG
(US10202378, Example 60 | ethyl 4-[2-(3-aminophenyl...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#Cc1cccc(N)c1
PDB

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n/an/a 38.1n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346572
PNG
(4-(3-cyclopropyl-3-hydroxy-but-1-ynyl)-2,6-dimethy...)
Show SMILES CC(CN1CCOCC1)c1nnc(o1)-c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)C1CC1
PDB

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n/an/a 38.3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346445
PNG
(US10202378, Example 58 | ethyl 4-[2-(4-methoxyphen...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#Cc1ccc(OC)cc1
PDB

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n/an/a 38.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346450
PNG
(US10202378, Example 63 | ethyl 4-[2-(3-hydroxyphen...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#Cc1cccc(O)c1
PDB

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n/an/a 38.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346465
PNG
(US10202378, Example 78 | ethyl 4-(3-hydroxy-3-meth...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(C)O
PDB

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n/an/a 38.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346401
PNG
(US10202378, Example 16 | ethyl 4-(3-hydroxy-3-meth...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)Cc1ccccc1
PDB

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US Patent
n/an/a 38.8n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346543
PNG
(1,1-dimethylbutyl 4-(3-hydroxy-3-methyl-but-1-ynyl...)
Show SMILES CCCC(C)(C)OC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(C)O
PDB

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n/an/a 38.8n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%