BindingDB logo
myBDB logout

Patent code US10202378

Compile Data Set for Download or QSAR

Found 434 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346431
PNG
(US10202378, Example 44 | ethyl 2,6-dimethyl-7-oxo-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1cccc(c1)-c1cc[nH]n1)C(F)(F)F
Show InChI InChI=1/C25H21F3N4O4/c1-4-36-23(34)19-14(2)30-21-20(19)16(13-32(3)22(21)33)8-10-24(35,25(26,27)28)17-7-5-6-15(12-17)18-9-11-29-31-18/h5-7,9,11-13,30,35H,4H2,1-3H3,(H,29,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 17n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346545
PNG
(2-methylbutyl 4-(3-hydroxy-3-methyl-but-1-ynyl)-2,...)
Show SMILES CCC(C)COC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1/C20H26N2O4/c1-7-12(2)11-26-19(24)15-13(3)21-17-16(15)14(8-9-20(4,5)25)10-22(6)18(17)23/h10,12,21,25H,7,11H2,1-6H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 19.4n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346540
PNG
((1-acetyl-4-piperidyl)methyl4-(3-hydroxy-3-methyl-...)
Show SMILES CC(=O)N1CCC(COC(=O)c2c(C)[nH]c3c2c(cn(C)c3=O)C#CC(C)(C)O)CC1
Show InChI InChI=1S/C23H29N3O5/c1-14-18(22(29)31-13-16-7-10-26(11-8-16)15(2)27)19-17(6-9-23(3,4)30)12-25(5)21(28)20(19)24-14/h12,16,24,30H,7-8,10-11,13H2,1-5H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 20.1n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346476
PNG
(US10202378, Example 89 | US10202378, Example 93a |...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(C(F)F)c1ccccc1
Show InChI InChI=1/C22H20F2N2O4/c1-4-30-20(28)16-13(2)25-18-17(16)14(12-26(3)19(18)27)10-11-22(29,21(23)24)15-8-6-5-7-9-15/h5-9,12,21,25,29H,4H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 21.4n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346428
PNG
(US10202378, Example 41 | ethyl 2,6-dimethyl-7-oxo-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1cccc(c1)-c1cn[nH]c1)C(F)(F)F
Show InChI InChI=1/C25H21F3N4O4/c1-4-36-23(34)19-14(2)31-21-20(19)16(13-32(3)22(21)33)8-9-24(35,25(26,27)28)18-7-5-6-15(10-18)17-11-29-30-12-17/h5-7,10-13,31,35H,4H2,1-3H3,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 21.5n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346517
PNG
(US10202378, Example 121 | o-tolylmethyl 4-(3-hydro...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1C)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C23H24N2O4/c1-14-8-6-7-9-17(14)13-29-22(27)18-15(2)24-20-19(18)16(10-11-23(3,4)28)12-25(5)21(20)26/h6-9,12,24,28H,13H2,1-5H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 21.5n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346561
PNG
((3-amino-1,1-dimethyl-propyl) 4-(3-hydroxy-3-methy...)
Show SMILES Cc1[nH]c2c(c1C(=O)OC(C)(C)CCN)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C20H27N3O4/c1-12-14(18(25)27-20(4,5)9-10-21)15-13(7-8-19(2,3)26)11-23(6)17(24)16(15)22-12/h11,22,26H,9-10,21H2,1-6H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 21.7n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346405
PNG
(US10202378, Example 20 | ethyl 4-[2-(1-hydroxycycl...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC1(O)CCCC1
Show InChI InChI=1S/C19H22N2O4/c1-4-25-18(23)14-12(2)20-16-15(14)13(11-21(3)17(16)22)7-10-19(24)8-5-6-9-19/h11,20,24H,4-6,8-9H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 21.9n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346467
PNG
(US10202378, Example 80 | ethyl 4-(3-hydroxy-3-phen...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)c1ccccc1
Show InChI InChI=1/C22H22N2O4/c1-5-28-21(26)17-14(2)23-19-18(17)15(13-24(4)20(19)25)11-12-22(3,27)16-9-7-6-8-10-16/h6-10,13,23,27H,5H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 22.6n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346549
PNG
(US10202378, Example 153 | cyclohexylmethyl 4-(3-hy...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCC1CCCCC1)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C22H28N2O4/c1-14-17(21(26)28-13-15-8-6-5-7-9-15)18-16(10-11-22(2,3)27)12-24(4)20(25)19(18)23-14/h12,15,23,27H,5-9,13H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 22.6n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346544
PNG
(US10202378, Example 148 | cyclopentylmethyl 4-(3-h...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCC1CCCC1)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C21H26N2O4/c1-13-16(20(25)27-12-14-7-5-6-8-14)17-15(9-10-21(2,3)26)11-23(4)19(24)18(17)22-13/h11,14,22,26H,5-8,12H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 23.7n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346509
PNG
((2-methoxyphenyl)methyl-4-(3-hydroxy-3-methyl-but-...)
Show SMILES COc1ccccc1COC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C23H24N2O5/c1-14-18(22(27)30-13-16-8-6-7-9-17(16)29-5)19-15(10-11-23(2,3)28)12-25(4)21(26)20(19)24-14/h6-9,12,24,28H,13H2,1-5H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 24n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346515
PNG
((2-fluorophenyl)methyl 4-(3-hydroxy-3-methyl-but-1...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1F)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C22H21FN2O4/c1-13-17(21(27)29-12-15-7-5-6-8-16(15)23)18-14(9-10-22(2,3)28)11-25(4)20(26)19(18)24-13/h5-8,11,24,28H,12H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 26.7n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346530
PNG
((2-cyano-1,1-dimethyl-ethyl)-4-(3-cyclopropyl-3-hy...)
Show SMILES Cc1[nH]c2c(c1C(=O)OC(C)(C)CC#N)c(cn(C)c2=O)C#CC(C)(O)C1CC1
Show InChI InChI=1/C22H25N3O4/c1-13-16(20(27)29-21(2,3)10-11-23)17-14(8-9-22(4,28)15-6-7-15)12-25(5)19(26)18(17)24-13/h12,15,24,28H,6-7,10H2,1-5H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 26.8n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346496
PNG
(US10202378, Example 100 | ethyl 2,6-dimethyl-7-oxo...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1cccc(c1)-c1cccnc1)C(F)(F)F
Show InChI InChI=1/C27H22F3N3O4/c1-4-37-25(35)21-16(2)32-23-22(21)19(15-33(3)24(23)34)10-11-26(36,27(28,29)30)20-9-5-7-17(13-20)18-8-6-12-31-14-18/h5-9,12-15,32,36H,4H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 27.3n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346559
PNG
((2-cyano-1,1-dimethyl-ethyl)4-(3-hydroxy-3-methyl-...)
Show SMILES Cc1[nH]c2c(c1C(=O)OC(C)(C)CC#N)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C20H23N3O4/c1-12-14(18(25)27-20(4,5)9-10-21)15-13(7-8-19(2,3)26)11-23(6)17(24)16(15)22-12/h11,22,26H,9H2,1-6H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 27.3n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346484
PNG
(3-(5-isopropyl-1,3,4-oxadiazol-2-yl)-2,6-dimethyl-...)
Show SMILES CC(C)c1nnc(o1)-c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1ccccc1)C(F)(F)F
Show InChI InChI=1/C24H21F3N4O3/c1-13(2)20-29-30-21(34-20)17-14(3)28-19-18(17)15(12-31(4)22(19)32)10-11-23(33,24(25,26)27)16-8-6-5-7-9-16/h5-9,12-13,28,33H,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 27.6n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346512
PNG
(US10202378, Example 116 | [2-(trifluoromethyl)phen...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1C(F)(F)F)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C23H21F3N2O4/c1-13-17(21(30)32-12-15-7-5-6-8-16(15)23(24,25)26)18-14(9-10-22(2,3)31)11-28(4)20(29)19(18)27-13/h5-8,11,27,31H,12H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 27.7n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346575
PNG
(4-(3-cyclopropyl-3-hydroxy-but-1-ynyl)-3-(5-isobut...)
Show SMILES CC(C)Cc1nnc(o1)-c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)C1CC1
Show InChI InChI=1/C22H26N4O3/c1-12(2)10-16-24-25-20(29-16)17-13(3)23-19-18(17)14(11-26(5)21(19)27)8-9-22(4,28)15-6-7-15/h11-12,15,23,28H,6-7,10H2,1-5H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 29.2n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346591
PNG
(4-(3-hydroxy-3-methyl-but-1-ynyl)-3-(5-isopropyl-1...)
Show SMILES CC(C)c1nnc(o1)-c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C19H22N4O3/c1-10(2)16-21-22-17(26-16)13-11(3)20-15-14(13)12(7-8-19(4,5)25)9-23(6)18(15)24/h9-10,20,25H,1-6H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 29.4n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346506
PNG
((2-cyanophenyl)methyl 4-(3-hydroxy-3-methyl-but-1-...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1C#N)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C23H21N3O4/c1-14-18(22(28)30-13-17-8-6-5-7-15(17)11-24)19-16(9-10-23(2,3)29)12-26(4)21(27)20(19)25-14/h5-8,12,25,29H,13H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 29.4n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346528
PNG
(US10202378, Example 132 | isobutyl 4-(3-hydroxy-3-...)
Show SMILES CC(C)COC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C19H24N2O4/c1-11(2)10-25-18(23)14-12(3)20-16-15(14)13(7-8-19(4,5)24)9-21(6)17(16)22/h9,11,20,24H,10H2,1-6H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 29.9n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346404
PNG
(US10202378, Example 19 | ethyl 4-[3-(3-cyanophenyl...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)c1cccc(c1)C#N
Show InChI InChI=1/C23H21N3O4/c1-5-30-22(28)18-14(2)25-20-19(18)16(13-26(4)21(20)27)9-10-23(3,29)17-8-6-7-15(11-17)12-24/h6-8,11,13,25,29H,5H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 30.3n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346546
PNG
(2,2-dimethylpropyl 4-(3-hydroxy-3-methyl-but-1-yny...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCC(C)(C)C)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C20H26N2O4/c1-12-14(18(24)26-11-19(2,3)4)15-13(8-9-20(5,6)25)10-22(7)17(23)16(15)21-12/h10,21,25H,11H2,1-7H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 30.4n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346490
PNG
(4-(3-cyclopropyl-3-hydroxy-but-1-ynyl)-3-[5-[(dime...)
Show SMILES CN(C)Cc1nnc(o1)-c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)C1CC1
Show InChI InChI=1/C21H25N5O3/c1-12-16(19-24-23-15(29-19)11-25(3)4)17-13(8-9-21(2,28)14-6-7-14)10-26(5)20(27)18(17)22-12/h10,14,22,28H,6-7,11H2,1-5H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 30.8n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346529
PNG
(US10202378, Example 133 | tert-butyl 4-(3-hydroxy-...)
Show SMILES Cc1[nH]c2c(c1C(=O)OC(C)(C)C)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C19H24N2O4/c1-11-13(17(23)25-18(2,3)4)14-12(8-9-19(5,6)24)10-21(7)16(22)15(14)20-11/h10,20,24H,1-7H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 31.1n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346562
PNG
(2-cyanoethyl 2,6-dimethyl-7-oxo-4-(4,4,4-trifluoro...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCCC#N)c(cn(C)c2=O)C#CC(O)(c1ccccc1)C(F)(F)F
Show InChI InChI=1/C23H18F3N3O4/c1-14-17(21(31)33-12-6-11-27)18-15(13-29(2)20(30)19(18)28-14)9-10-22(32,23(24,25)26)16-7-4-3-5-8-16/h3-5,7-8,13,28,32H,6,12H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 31.2n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346556
PNG
(US10202378, Example 160 | isobutyl 4-(3-hydroxy-3-...)
Show SMILES CC(C)COC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)c1ccccc1
Show InChI InChI=1/C24H26N2O4/c1-15(2)14-30-23(28)19-16(3)25-21-20(19)17(13-26(5)22(21)27)11-12-24(4,29)18-9-7-6-8-10-18/h6-10,13,15,25,29H,14H2,1-5H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 32.4n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346476
PNG
(US10202378, Example 89 | US10202378, Example 93a |...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(C(F)F)c1ccccc1
Show InChI InChI=1/C22H20F2N2O4/c1-4-30-20(28)16-13(2)25-18-17(16)14(12-26(3)19(18)27)10-11-22(29,21(23)24)15-8-6-5-7-9-15/h5-9,12,21,25,29H,4H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 32.9n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346464
PNG
(US10202378, Example 77 | US10202378, Example 92a |...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)C1CC1
Show InChI InChI=1/C19H22N2O4/c1-5-25-18(23)14-11(2)20-16-15(14)12(10-21(4)17(16)22)8-9-19(3,24)13-6-7-13/h10,13,20,24H,5-7H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 33.2n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346492
PNG
(3-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-4-(3-cyclopr...)
Show SMILES Cc1[nH]c2c(c1-c1nnc(o1)C(C)(C)C)c(cn(C)c2=O)C#CC(C)(O)C1CC1
Show InChI InChI=1/C22H26N4O3/c1-12-15(18-24-25-20(29-18)21(2,3)4)16-13(9-10-22(5,28)14-7-8-14)11-26(6)19(27)17(16)23-12/h11,14,23,28H,7-8H2,1-6H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 33.9n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346592
PNG
(US10202378, Example 197 | ethyl 4-[3-(3-carbamoylp...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1cccc(c1)C(N)=O)C(F)(F)F
Show InChI InChI=1/C23H20F3N3O5/c1-4-34-21(32)16-12(2)28-18-17(16)14(11-29(3)20(18)31)8-9-22(33,23(24,25)26)15-7-5-6-13(10-15)19(27)30/h5-7,10-11,28,33H,4H2,1-3H3,(H2,27,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 34.1n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346511
PNG
(2-pyridylmethyl 4-(3-hydroxy-3-methyl-but-1-ynyl)-...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccn1)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C21H21N3O4/c1-13-16(20(26)28-12-15-7-5-6-10-22-15)17-14(8-9-21(2,3)27)11-24(4)19(25)18(17)23-13/h5-7,10-11,23,27H,12H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 34.1n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346499
PNG
(Benzyl 4-(3-hydroxy-3-methyl-but-1-ynyl)-2,6-dimet...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C22H22N2O4/c1-14-17(21(26)28-13-15-8-6-5-7-9-15)18-16(10-11-22(2,3)27)12-24(4)20(25)19(18)23-14/h5-9,12,23,27H,13H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 34.5n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346501
PNG
(8-quinolylmethyl 4-(3-cyclopropyl-3-hydroxy-but-1-...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1cccc3cccnc13)c(cn(C)c2=O)C#CC(C)(O)C1CC1
Show InChI InChI=1/C27H25N3O4/c1-16-21(26(32)34-15-19-7-4-6-17-8-5-13-28-23(17)19)22-18(11-12-27(2,33)20-9-10-20)14-30(3)25(31)24(22)29-16/h4-8,13-14,20,29,33H,9-10,15H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 34.6n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346547
PNG
(1,1-dimethylpropyl 4-(3-hydroxy-3-methyl-but-1-yny...)
Show SMILES CCC(C)(C)OC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C20H26N2O4/c1-8-20(5,6)26-18(24)14-12(2)21-16-15(14)13(9-10-19(3,4)25)11-22(7)17(16)23/h11,21,25H,8H2,1-7H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 35.1n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346430
PNG
(US10202378, Example 43 | ethyl 2,6-dimethyl-7-oxo-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1cccc(CO)c1)C(F)(F)F
Show InChI InChI=1/C23H21F3N2O5/c1-4-33-21(31)17-13(2)27-19-18(17)15(11-28(3)20(19)30)8-9-22(32,23(24,25)26)16-7-5-6-14(10-16)12-29/h5-7,10-11,27,29,32H,4,12H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 35.5n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346587
PNG
(4-(3-cyclopropyl-3-hydroxy-but-1-ynyl)-3-(5-isopro...)
Show SMILES CC(C)c1nnc(o1)-c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)C1CC1
Show InChI InChI=1/C21H24N4O3/c1-11(2)18-23-24-19(28-18)15-12(3)22-17-16(15)13(10-25(5)20(17)26)8-9-21(4,27)14-6-7-14/h10-11,14,22,27H,6-7H2,1-5H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 36.4n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346532
PNG
((2-cyano-1,1-dimethyl-ethyl)2,6-dimethyl-7-oxo-4-(...)
Show SMILES Cc1[nH]c2c(c1C(=O)OC(C)(C)CC#N)c(cn(C)c2=O)C#CC(O)(c1ccccc1)C(F)(F)F
Show InChI InChI=1/C25H22F3N3O4/c1-15-18(22(33)35-23(2,3)12-13-29)19-16(14-31(4)21(32)20(19)30-15)10-11-24(34,25(26,27)28)17-8-6-5-7-9-17/h5-9,14,30,34H,12H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 36.5n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346555
PNG
(US10202378, Example 159 | cyclohexyl 4-(3-hydroxy-...)
Show SMILES Cc1[nH]c2c(c1C(=O)OC1CCCCC1)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C21H26N2O4/c1-13-16(20(25)27-15-8-6-5-7-9-15)17-14(10-11-21(2,3)26)12-23(4)19(24)18(17)22-13/h12,15,22,26H,5-9H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 36.9n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346502
PNG
(US10202378, Example 106 | [3-(hydroxymethyl)phenyl...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1cccc(CO)c1)c(cn(C)c2=O)C#CC(C)(O)C1CC1
Show InChI InChI=1/C25H26N2O5/c1-15-20(24(30)32-14-17-6-4-5-16(11-17)13-28)21-18(9-10-25(2,31)19-7-8-19)12-27(3)23(29)22(21)26-15/h4-6,11-12,19,26,28,31H,7-8,13-14H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 37.2n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346536
PNG
(3-acetamidopropyl 4-(3-cyclopropyl-3-hydroxy-but-1...)
Show SMILES CC(=O)NCCCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)C1CC1
Show InChI InChI=1/C22H27N3O5/c1-13-17(21(28)30-11-5-10-23-14(2)26)18-15(8-9-22(3,29)16-6-7-16)12-25(4)20(27)19(18)24-13/h12,16,24,29H,5-7,10-11H2,1-4H3,(H,23,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 37.5n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346507
PNG
(US10202378, Example 111 | [2-(hydroxymethyl)phenyl...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1CO)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C23H24N2O5/c1-14-18(22(28)30-13-17-8-6-5-7-16(17)12-26)19-15(9-10-23(2,3)29)11-25(4)21(27)20(19)24-14/h5-8,11,24,26,29H,12-13H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 37.9n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346447
PNG
(US10202378, Example 60 | ethyl 4-[2-(3-aminophenyl...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#Cc1cccc(N)c1
Show InChI InChI=1S/C20H19N3O3/c1-4-26-20(25)16-12(2)22-18-17(16)14(11-23(3)19(18)24)9-8-13-6-5-7-15(21)10-13/h5-7,10-11,22H,4,21H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 38.1n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346572
PNG
(4-(3-cyclopropyl-3-hydroxy-but-1-ynyl)-2,6-dimethy...)
Show SMILES CC(CN1CCOCC1)c1nnc(o1)-c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)C1CC1
Show InChI InChI=1/C25H31N5O4/c1-15(13-30-9-11-33-12-10-30)22-27-28-23(34-22)19-16(2)26-21-20(19)17(14-29(4)24(21)31)7-8-25(3,32)18-5-6-18/h14-15,18,26,32H,5-6,9-13H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 38.3n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346445
PNG
(US10202378, Example 58 | ethyl 4-[2-(4-methoxyphen...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#Cc1ccc(OC)cc1
Show InChI InChI=1S/C21H20N2O4/c1-5-27-21(25)17-13(2)22-19-18(17)15(12-23(3)20(19)24)9-6-14-7-10-16(26-4)11-8-14/h7-8,10-12,22H,5H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 38.4n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346450
PNG
(US10202378, Example 63 | ethyl 4-[2-(3-hydroxyphen...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#Cc1cccc(O)c1
Show InChI InChI=1S/C20H18N2O4/c1-4-26-20(25)16-12(2)21-18-17(16)14(11-22(3)19(18)24)9-8-13-6-5-7-15(23)10-13/h5-7,10-11,21,23H,4H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 38.5n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346465
PNG
(US10202378, Example 78 | ethyl 4-(3-hydroxy-3-meth...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C17H20N2O4/c1-6-23-16(21)12-10(2)18-14-13(12)11(7-8-17(3,4)22)9-19(5)15(14)20/h9,18,22H,6H2,1-5H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 38.5n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346401
PNG
(US10202378, Example 16 | ethyl 4-(3-hydroxy-3-meth...)
Show SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)Cc1ccccc1
Show InChI InChI=1/C23H24N2O4/c1-5-29-22(27)18-15(2)24-20-19(18)17(14-25(4)21(20)26)11-12-23(3,28)13-16-9-7-6-8-10-16/h6-10,14,24,28H,5,13H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 38.8n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (Human))
BDBM346543
PNG
(1,1-dimethylbutyl 4-(3-hydroxy-3-methyl-but-1-ynyl...)
Show SMILES CCCC(C)(C)OC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C21H28N2O4/c1-8-10-21(5,6)27-19(25)15-13(2)22-17-16(15)14(9-11-20(3,4)26)12-23(7)18(17)24/h12,22,26H,8,10H2,1-7H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 38.8n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10202378 (2019)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 434 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%