BindingDB logo
myBDB logout

Patent code US10202403

Compile Data Set for Download or QSAR
Found 19 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347077
PNG
(US10202403, Compound 1002)
Show SMILES CNC(=O)c1c(oc2ccc3OC(Cc3c12)C=C)-c1ccc(F)cc1
Show InChI InChI=1S/C20H16FNO3/c1-3-13-10-14-15(24-13)8-9-16-17(14)18(20(23)22-2)19(25-16)11-4-6-12(21)7-5-11/h3-9,13H,1,10H2,2H3,(H,22,23)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 672n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347087
PNG
(US10202403, Compound 1012)
Show SMILES CNC(=O)c1c(oc2ccc3OCCCCCCCCCCCc3c12)-c1ccc(F)cc1
Show InChI InChI=1S/C27H32FNO3/c1-29-27(30)25-24-21-11-9-7-5-3-2-4-6-8-10-18-31-22(21)16-17-23(24)32-26(25)19-12-14-20(28)15-13-19/h12-17H,2-11,18H2,1H3,(H,29,30)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 530n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347095
PNG
(US10202403, Compound 2005)
Show SMILES CNC(=O)c1c(oc2ccc3OCC4(CC4)Cc4c(OCC5(CC5)Cc3c12)ccc1oc(c(C(=O)NC)c41)-c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C42H36F2N2O6/c1-45-39(47)35-33-27-19-41(15-16-41)21-50-30-12-14-32-34(36(40(48)46-2)38(52-32)24-5-9-26(44)10-6-24)28(30)20-42(17-18-42)22-49-29(27)11-13-31(33)51-37(35)23-3-7-25(43)8-4-23/h3-14H,15-22H2,1-2H3,(H,45,47)(H,46,48)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 931n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347085
PNG
(US10202403, Compound 1010 | US10202403, Compound 1...)
Show SMILES CNC(=O)c1c(oc2ccc3OCCCCCCCCCc3c12)-c1ccc(F)cc1
Show InChI InChI=1S/C25H28FNO3/c1-27-25(28)23-22-19-9-7-5-3-2-4-6-8-16-29-20(19)14-15-21(22)30-24(23)17-10-12-18(26)13-11-17/h10-15H,2-9,16H2,1H3,(H,27,28)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.63E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347080
PNG
(US10202403, Compound 1005)
Show SMILES CNC(=O)c1c(oc2ccc3OCc4cccc(CCc3c12)c4)-c1ccc(F)cc1
Show InChI InChI=1S/C25H20FNO3/c1-27-25(28)23-22-19-10-5-15-3-2-4-16(13-15)14-29-20(19)11-12-21(22)30-24(23)17-6-8-18(26)9-7-17/h2-4,6-9,11-13H,5,10,14H2,1H3,(H,27,28)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347089
PNG
(US10202403, Compound 1014)
Show SMILES CNC(=O)c1c(oc2ccc3OCCN(CCc3c12)S(=O)(=O)c1ccc(C)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H25FN2O5S/c1-17-3-9-20(10-4-17)36(32,33)30-14-13-21-22(34-16-15-30)11-12-23-24(21)25(27(31)29-2)26(35-23)18-5-7-19(28)8-6-18/h3-12H,13-16H2,1-2H3,(H,29,31)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347090
PNG
(US10202403, Compound 1015)
Show SMILES CNC(=O)c1c(oc2ccc3OCC(=O)NCCNC(=O)Cc3c12)-c1ccc(F)cc1
Show InChI InChI=1S/C22H20FN3O5/c1-24-22(29)20-19-14-10-17(27)25-8-9-26-18(28)11-30-15(14)6-7-16(19)31-21(20)12-2-4-13(23)5-3-12/h2-7H,8-11H2,1H3,(H,24,29)(H,25,27)(H,26,28)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347094
PNG
(US10202403, Compound 2004)
Show SMILES CNC(=O)c1c(oc2ccc3OCc4cccc(Cc5c(OCc6cccc(Cc3c12)c6)ccc1oc(c(C(=O)NC)c51)-c1ccc(F)cc1)c4)-c1ccc(F)cc1
Show InChI InChI=1S/C48H36F2N2O6/c1-51-47(53)43-41-35-23-27-5-3-7-29(21-27)26-56-38-18-20-40-42(44(48(54)52-2)46(58-40)32-11-15-34(50)16-12-32)36(38)24-28-6-4-8-30(22-28)25-55-37(35)17-19-39(41)57-45(43)31-9-13-33(49)14-10-31/h3-22H,23-26H2,1-2H3,(H,51,53)(H,52,54)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347078
PNG
(US10202403, Compound 1003)
Show SMILES CNC(=O)c1c(oc2ccc3OCc4ccccc4-c4ccccc4Cc3c12)-c1ccc(F)cc1
Show InChI InChI=1S/C30H22FNO3/c1-32-30(33)28-27-24-16-19-6-2-4-8-22(19)23-9-5-3-7-20(23)17-34-25(24)14-15-26(27)35-29(28)18-10-12-21(31)13-11-18/h2-15H,16-17H2,1H3,(H,32,33)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.84E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347079
PNG
(US10202403, Compound 1004)
Show SMILES CNC(=O)c1c(oc2ccc3OCc4cccc5cccc(Cc3c12)c45)-c1ccc(F)cc1
Show InChI InChI=1S/C28H20FNO3/c1-30-28(31)26-25-21-14-18-6-2-4-16-5-3-7-19(24(16)18)15-32-22(21)12-13-23(25)33-27(26)17-8-10-20(29)11-9-17/h2-13H,14-15H2,1H3,(H,30,31)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347084
PNG
(US10202403, Compound 1009)
Show SMILES CNC(=O)c1c(oc2ccc3OCCCCCCCCc3c12)-c1ccc(F)cc1
Show InChI InChI=1S/C24H26FNO3/c1-26-24(27)22-21-18-8-6-4-2-3-5-7-15-28-19(18)13-14-20(21)29-23(22)16-9-11-17(25)12-10-16/h9-14H,2-8,15H2,1H3,(H,26,27)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.08E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347093
PNG
(US10202403, Compound 2002)
Show SMILES CNC(=O)c1c(oc2ccc3OCC(=O)Cc4c(OCC(=C)Cc3c12)ccc1oc(c(C(=O)NC)c41)-c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C39H30F2N2O7/c1-20-16-26-28(12-14-30-32(26)34(38(45)42-2)36(49-30)21-4-8-23(40)9-5-21)48-19-25(44)17-27-29(47-18-20)13-15-31-33(27)35(39(46)43-3)37(50-31)22-6-10-24(41)11-7-22/h4-15H,1,16-19H2,2-3H3,(H,42,45)(H,43,46)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.65E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347076
PNG
(US10202403, Compound 1001)
Show SMILES CNC(=O)c1c(oc2ccc3OCC=CCc3c12)-c1ccc(F)cc1
Show InChI InChI=1S/C20H16FNO3/c1-22-20(23)18-17-14-4-2-3-11-24-15(14)9-10-16(17)25-19(18)12-5-7-13(21)8-6-12/h2-3,5-10H,4,11H2,1H3,(H,22,23)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.08E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347083
PNG
(US10202403, Compound 1008)
Show SMILES CNC(=O)c1c(oc2ccc3OCCCCCCCc3c12)-c1ccc(F)cc1
Show InChI InChI=1S/C23H24FNO3/c1-25-23(26)21-20-17-7-5-3-2-4-6-14-27-18(17)12-13-19(20)28-22(21)15-8-10-16(24)11-9-15/h8-13H,2-7,14H2,1H3,(H,25,26)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.82E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347081
PNG
(US10202403, Compound 1006)
Show SMILES CNC(=O)c1c(oc2ccc3OCCOCCOCCc3c12)-c1ccc(F)cc1
Show InChI InChI=1S/C22H22FNO5/c1-24-22(25)20-19-16-8-9-26-10-11-27-12-13-28-17(16)6-7-18(19)29-21(20)14-2-4-15(23)5-3-14/h2-7H,8-13H2,1H3,(H,24,25)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347082
PNG
(US10202403, Compound 1007)
Show SMILES CNC(=O)c1c(oc2ccc3OCCCCCCc3c12)-c1ccc(F)cc1
Show InChI InChI=1S/C22H22FNO3/c1-24-22(25)20-19-16-6-4-2-3-5-13-26-17(16)11-12-18(19)27-21(20)14-7-9-15(23)10-8-14/h7-12H,2-6,13H2,1H3,(H,24,25)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.29E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347091
PNG
(US10202403, Compound 2001)
Show SMILES CNC(=O)c1c(oc2ccc3OCc4cccc(Cc5c(OCc6cccc(Cc3c12)n6)ccc1oc(c(C(=O)NC)c51)-c1ccc(F)cc1)n4)-c1ccc(F)cc1
Show InChI InChI=1S/C46H34F2N4O6/c1-49-45(53)41-39-33-21-29-5-3-7-32(51-29)24-56-36-18-20-38-40(42(46(54)50-2)44(58-38)26-11-15-28(48)16-12-26)34(36)22-30-6-4-8-31(52-30)23-55-35(33)17-19-37(39)57-43(41)25-9-13-27(47)14-10-25/h3-20H,21-24H2,1-2H3,(H,49,53)(H,50,54)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6.67E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347085
PNG
(US10202403, Compound 1010 | US10202403, Compound 1...)
Show SMILES CNC(=O)c1c(oc2ccc3OCCCCCCCCCc3c12)-c1ccc(F)cc1
Show InChI InChI=1S/C25H28FNO3/c1-27-25(28)23-22-19-9-7-5-3-2-4-6-8-16-29-20(19)14-15-21(22)30-24(23)17-10-12-18(26)13-11-17/h10-15H,2-9,16H2,1H3,(H,27,28)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.09E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347088
PNG
(US10202403, Compound 1013)
Show SMILES CNC(=O)c1c(oc2ccc3OCCCCCCCCCCCCc3c12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H34FNO3/c1-30-28(31)26-25-22-12-10-8-6-4-2-3-5-7-9-11-19-32-23(22)17-18-24(25)33-27(26)20-13-15-21(29)16-14-20/h13-18H,2-12,19H2,1H3,(H,30,31)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.51E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An on-bead solid phase homogeneous assay was used in a 384-well format to assess NS5B inhibitors (WangY-K, Rigat K, Roberts S, and Gao M (2006) Anal ...


US Patent US10202403 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%