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Patent code US10202411

Compile Data Set for Download or QSAR
Found 20 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347258
PNG
(US10202411, Compound 301)
Show SMILES O[C@H]1[C@@H](O[C@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)[C@H]1C(F)F)n1ccc(=O)[nH]c1=O
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347269
PNG
(US10202411, Compound 334)
Show SMILES OC[C@H]1C[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)n1ccc(=O)[nH]c1=O
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347270
PNG
(US10202411, Compound 335)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1C[C@H](CO)[C@@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)O1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347271
PNG
(US10202411, Compound 401)
Show SMILES OC[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)([O-])=O)n1ccc(=O)[nH]c1=O
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347261
PNG
(US10202411, Compound 307)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](CO)[C@H]1O
Show InChI InChI=1S/C11H18N5O13P3/c12-9-7-10(14-3-13-9)16(4-15-7)11-8(18)5(1-17)6(27-11)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-6,8,11,17-18H,1-2H2,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t5-,6-,8-,11-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 625n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347262
PNG
(US10202411, Compound 308)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](CO)[C@H]1O
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347263
PNG
(US10202411, Compound 325)
Show SMILES OC[C@@H]1[C@@H](COP(O)(=O)OP([O-])(=O)OP([O-])([O-])=O)O[C@H]([C@@H]1F)n1ccc(=O)[nH]c1=O
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
HCV NS5B Mutant(S282T)


(Hepatitis C virus genotype 1b (isolate Japanese) (...)
BDBM347259
PNG
(US10202411, Compound 302)
Show SMILES O[C@@H]1[C@H](CF)[C@@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)O[C@H]1n1ccc(=O)[nH]c1=O
PDB
MMDB

B.MOAD
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
HCV NS5B Mutant(S282T)


(Hepatitis C virus genotype 1b (isolate Japanese) (...)
BDBM347260
PNG
(US10202411, Compound 305)
Show SMILES OC[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)n1ccc(=O)[nH]c1=O
PDB
MMDB

B.MOAD
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
HCV NS5B Mutant(S282T)


(Hepatitis C virus genotype 1b (isolate Japanese) (...)
BDBM347266
PNG
(US10202411, Compound 330)
Show SMILES Nc1nc(N)c2ncn([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](CO)[C@H]3O)c2n1
Show InChI InChI=1S/C11H19N6O13P3/c12-8-6-9(16-11(13)15-8)17(3-14-6)10-7(19)4(1-18)5(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-5,7,10,18-19H,1-2H2,(H,23,24)(H,25,26)(H2,20,21,22)(H4,12,13,15,16)/p-3/t4-,5-,7-,10-/m1/s1
PDB
MMDB

B.MOAD
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347267
PNG
(US10202411, Compound 331)
Show SMILES Nc1nc2n(nnc2c(=O)[nH]1)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](CO)[C@H]1O
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347259
PNG
(US10202411, Compound 302)
Show SMILES O[C@@H]1[C@H](CF)[C@@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)O[C@H]1n1ccc(=O)[nH]c1=O
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347260
PNG
(US10202411, Compound 305)
Show SMILES OC[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)n1ccc(=O)[nH]c1=O
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347264
PNG
(US10202411, Compound 326)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](CF)[C@H]1O
Show InChI InChI=1S/C11H17FN5O12P3/c12-1-5-6(2-26-31(22,23)29-32(24,25)28-30(19,20)21)27-11(8(5)18)17-4-16-7-9(13)14-3-15-10(7)17/h3-6,8,11,18H,1-2H2,(H,22,23)(H,24,25)(H2,13,14,15)(H2,19,20,21)/t5-,6-,8-,11-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
HCV NS5B Mutant(S282T)


(Hepatitis C virus genotype 1b (isolate Japanese) (...)
BDBM347262
PNG
(US10202411, Compound 308)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](CO)[C@H]1O
PDB
MMDB

B.MOAD
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347268
PNG
(US10202411, Compound 332)
Show SMILES Cc1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](CO)[C@H]2O)c(=O)[nH]c1=O
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 625n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347272
PNG
(US10202411, Compound 402)
Show SMILES OC[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP([O-])([O-])=O)n1ccc(=O)[nH]c1=O
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
HCV NS5B Mutant(S282T)


(Hepatitis C virus genotype 1b (isolate Japanese) (...)
BDBM347265
PNG
(US10202411, Compound 327)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](CF)[C@H]1O
PDB
MMDB

B.MOAD
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347266
PNG
(US10202411, Compound 330)
Show SMILES Nc1nc(N)c2ncn([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](CO)[C@H]3O)c2n1
Show InChI InChI=1S/C11H19N6O13P3/c12-8-6-9(16-11(13)15-8)17(3-14-6)10-7(19)4(1-18)5(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-5,7,10,18-19H,1-2H2,(H,23,24)(H,25,26)(H2,20,21,22)(H4,12,13,15,16)/p-3/t4-,5-,7-,10-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 625n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
NS3 serine protease (NS3)


(Hepatitis C Virus (Virus))
BDBM347265
PNG
(US10202411, Compound 327)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](CF)[C@H]1O
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/an/an/a



IDENIX PHARMACEUTICALS LLC

US Patent


Assay Description
Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...


US Patent US10202411 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%