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Patent code US10206931

Compile Data Set for Download or QSAR

Found 611 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM349483
PNG
((difluoromethyl)-6-(1- | US10206931, Example 291)
Show SMILES CN\C=C(/C=N)c1cc2CCCN(c2cc1C(F)F)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C24H27F2N5O/c1-14-9-22(32)30-19-6-3-7-20(23(19)29-14)31-8-4-5-15-10-17(16(12-27)13-28-2)18(24(25)26)11-21(15)31/h3,6-7,10-14,24,27-29H,4-5,8-9H2,1-2H3,(H,30,32)/b16-13+,27-12?/t14-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349496
PNG
((difluoromethyl)-5-(1- | US10206931, Example 304)
Show SMILES CN\C=C(/C=N)c1cc2CCN(c2cc1C(F)F)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C23H25F2N5O/c1-13-8-21(31)29-18-4-3-5-19(22(18)28-13)30-7-6-14-9-16(15(11-26)12-27-2)17(23(24)25)10-20(14)30/h3-5,9-13,23,26-28H,6-8H2,1-2H3,(H,29,31)/b15-12+,26-11?/t13-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349500
PNG
((R,R)-6-[7-(difluoromethyl)-4-methyl-6-(l-methylpy...)
Show SMILES CN\C=C(/C=N)c1cc2[C@@H](C)CCN(c2cc1C(F)F)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C25H29F2N5O/c1-14-7-8-32(21-6-4-5-20-24(21)30-15(2)9-23(33)31-20)22-11-19(25(26)27)18(10-17(14)22)16(12-28)13-29-3/h4-6,10-15,25,28-30H,7-9H2,1-3H3,(H,31,33)/b16-13+,28-12?/t14-,15+/m0/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349498
PNG
(1-methyl-4-[(4R)-4-methyl-2-oxo-1,3,4,5-tetrahydro...)
Show SMILES CN\C=C(/C=N)c1cc2N(C)CCN(c3cccc4NC(=O)C[C@@H](C)Nc34)c2cc1C#N
Show InChI InChI=1S/C24H27N7O/c1-15-9-23(32)29-19-5-4-6-20(24(19)28-15)31-8-7-30(3)21-11-18(17(13-26)14-27-2)16(12-25)10-22(21)31/h4-6,10-11,13-15,26-28H,7-9H2,1-3H3,(H,29,32)/b17-14+,26-13?/t15-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349503
PNG
(5-[7-(difluoromethyl)-1-[(4R)-4-methyl-2-oxo-1,3,4...)
Show SMILES CNC(=O)c1ccc(cn1)-c1cc2CCCN(c2cc1C(F)F)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C27H27F2N5O2/c1-15-11-24(35)33-20-6-3-7-22(25(20)32-15)34-10-4-5-16-12-18(19(26(28)29)13-23(16)34)17-8-9-21(31-14-17)27(36)30-2/h3,6-9,12-15,26,32H,4-5,10-11H2,1-2H3,(H,30,36)(H,33,35)/t15-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349497
PNG
((4R)-6-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl...)
Show SMILES CN\C=C(/C=N)c1cc2CCCN(c2cc1C(F)F)c1nccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C23H26F2N6O/c1-13-8-20(32)30-18-5-6-28-23(21(18)29-13)31-7-3-4-14-9-16(15(11-26)12-27-2)17(22(24)25)10-19(14)31/h5-6,9-13,22,26-27,29H,3-4,7-8H2,1-2H3,(H,30,32)/b15-12+,26-11?/t13-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349484
PNG
(US10206931, Example 292 | oxo-1,3,4,5-tetrahydro-)
Show SMILES CN\C=C(/C=N)c1cc2CCCN(c2cc1C#N)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C24H26N6O/c1-15-9-23(31)29-20-6-3-7-21(24(20)28-15)30-8-4-5-16-10-19(18(13-26)14-27-2)17(12-25)11-22(16)30/h3,6-7,10-11,13-15,26-28H,4-5,8-9H2,1-2H3,(H,29,31)/b18-14+,26-13?/t15-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349491
PNG
((difluoromethyl)-2- | US10206931, Example 299)
Show SMILES CN\C=C(/C=N)c1cc(F)c(Nc2cccc3NC(=O)C[C@@H](C)Nc23)cc1C(F)F
Show InChI InChI=1S/C21H22F3N5O/c1-11-6-19(30)29-17-5-3-4-16(20(17)27-11)28-18-8-14(21(23)24)13(7-15(18)22)12(9-25)10-26-2/h3-5,7-11,21,25-28H,6H2,1-2H3,(H,29,30)/b12-10+,25-9?/t11-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349501
PNG
((R,S)-6-[7-(difluoromethyl)-3-methyl-6-(1-methylpy...)
Show SMILES CN\C=C(/C=N)c1cc2C[C@H](C)CN(c2cc1C(F)F)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C25H29F2N5O/c1-14-7-16-9-18(17(11-28)12-29-3)19(25(26)27)10-22(16)32(13-14)21-6-4-5-20-24(21)30-15(2)8-23(33)31-20/h4-6,9-12,14-15,25,28-30H,7-8,13H2,1-3H3,(H,31,33)/b17-12+,28-11?/t14-,15+/m0/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349504
PNG
((4R)-4-methyl-6-[3-(1-methylpyrazol-1-yl)-8-isoqui...)
Show SMILES CN\C=C(/C=N)c1cc2cccc(-c3cccc4NC(=O)C[C@@H](C)Nc34)c2cn1
Show InChI InChI=1S/C23H23N5O/c1-14-9-22(29)28-20-8-4-7-18(23(20)27-14)17-6-3-5-15-10-21(26-13-19(15)17)16(11-24)12-25-2/h3-8,10-14,24-25,27H,9H2,1-2H3,(H,28,29)/b16-12+,24-11?/t14-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349486
PNG
(US10206931, Example 294 | methyl-6-(1-)
Show SMILES CN\C=C(/C=N)c1ccc2N(CC[C@H](C)c2c1)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C24H29N5O/c1-15-9-10-29(21-8-7-17(12-19(15)21)18(13-25)14-26-3)22-6-4-5-20-24(22)27-16(2)11-23(30)28-20/h4-8,12-16,25-27H,9-11H2,1-3H3,(H,28,30)/b18-14+,25-13?/t15-,16+/m0/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349488
PNG
(US10206931, Example 296 | methylpyrazol-4-)
Show SMILES CN\C=C(/C=N)c1cccc(Nc2cccc3NC(=O)C[C@@H](C)Nc23)c1
Show InChI InChI=1S/C20H23N5O/c1-13-9-19(26)25-18-8-4-7-17(20(18)23-13)24-16-6-3-5-14(10-16)15(11-21)12-22-2/h3-8,10-13,21-24H,9H2,1-2H3,(H,25,26)/b15-12+,21-11?/t13-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349278
PNG
((2R)-6-fluoro-2- | US10206931, Example 85)
Show SMILES CN\C=C(/C=N)C(=N)c1cc(ccc1NC)-c1ccc(F)c2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C22H25FN6O/c1-12-8-19(30)29-22-17(23)6-5-15(21(22)28-12)13-4-7-18(27-3)16(9-13)20(25)14(10-24)11-26-2/h4-7,9-12,24-28H,8H2,1-3H3,(H,29,30)/b14-11+,24-10?,25-20?/t12-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349494
PNG
(US10206931, Example 302 | oxo-1,3,4,5-tetrahydro-)
Show SMILES CN\C=C(/C=N)c1cc2CCN(c2cc1C#N)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C23H24N6O/c1-14-8-22(30)28-19-4-3-5-20(23(19)27-14)29-7-6-15-9-18(17(12-25)13-26-2)16(11-24)10-21(15)29/h3-5,9-10,12-14,25-27H,6-8H2,1-2H3,(H,28,30)/b17-13+,25-12?/t14-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349492
PNG
(US10206931, Example 300 | methyl-2-oxo-1,3,4,5-)
Show SMILES CN\C=C(/C=N)c1cc(F)c(Nc2cccc3NC(=O)C[C@@H](C)Nc23)cc1C#N
Show InChI InChI=1S/C21H21FN6O/c1-12-6-20(29)28-18-5-3-4-17(21(18)26-12)27-19-7-13(9-23)15(8-16(19)22)14(10-24)11-25-2/h3-5,7-8,10-12,24-27H,6H2,1-2H3,(H,28,29)/b14-11+,24-10?/t12-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349482
PNG
((R)-4-methyl-6-(6-(1-methyl-1H-pyrazol-4-yl)-3,4-d...)
Show SMILES CN\C=C(/C=N)c1ccc2N(CCCc2c1)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C23H27N5O/c1-15-11-22(29)27-19-6-3-7-21(23(19)26-15)28-10-4-5-17-12-16(8-9-20(17)28)18(13-24)14-25-2/h3,6-9,12-15,24-26H,4-5,10-11H2,1-2H3,(H,27,29)/b18-14+,24-13?/t15-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349502
PNG
((R,S)-6-[7-(difluoromethyl)-3-methyl-6-(1-methylpy...)
Show SMILES CN\C=C(/C=N)c1cc2C[C@@H](C)CN(c2cc1C(F)F)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C25H29F2N5O/c1-14-7-16-9-18(17(11-28)12-29-3)19(25(26)27)10-22(16)32(13-14)21-6-4-5-20-24(21)30-15(2)8-23(33)31-20/h4-6,9-12,14-15,25,28-30H,7-8,13H2,1-3H3,(H,31,33)/b17-12+,28-11?/t14-,15-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349499
PNG
((R,R)-6-[7-(difluoromethyl)-4-methyl-6-(l-methylpy...)
Show SMILES CN\C=C(/C=N)c1cc2[C@H](C)CCN(c2cc1C(F)F)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C25H29F2N5O/c1-14-7-8-32(21-6-4-5-20-24(21)30-15(2)9-23(33)31-20)22-11-19(25(26)27)18(10-17(14)22)16(12-28)13-29-3/h4-6,10-15,25,28-30H,7-9H2,1-3H3,(H,31,33)/b16-13+,28-12?/t14-,15-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349226
PNG
((4R)-4-methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)...)
Show SMILES CN\C=C(/C=N)C(=N)c1cc(ccc1NC)-c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C22H26N6O/c1-13-9-20(29)28-19-6-4-5-16(22(19)27-13)14-7-8-18(26-3)17(10-14)21(24)15(11-23)12-25-2/h4-8,10-13,23-27H,9H2,1-3H3,(H,28,29)/b15-12+,23-11?,24-21?/t13-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349489
PNG
(US10206931, Example 297 | methylpyrazol-4-)
Show SMILES CN\C=C(/C=N)c1ccc(Nc2cccc3NC(=O)C[C@@H](C)Nc23)cc1
Show InChI InChI=1S/C20H23N5O/c1-13-10-19(26)25-18-5-3-4-17(20(18)23-13)24-16-8-6-14(7-9-16)15(11-21)12-22-2/h3-9,11-13,21-24H,10H2,1-2H3,(H,25,26)/b15-12+,21-11?/t13-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349277
PNG
((2R)-9-(3-cyclopropyl-1-methyl-indazol-5-yl)-6-flu...)
Show SMILES CNc1ccc(cc1C(=N)C1CC1)-c1ccc(F)c2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C21H23FN4O/c1-11-9-18(27)26-21-16(22)7-6-14(20(21)25-11)13-5-8-17(24-2)15(10-13)19(23)12-3-4-12/h5-8,10-12,23-25H,3-4,9H2,1-2H3,(H,26,27)/t11-/m1/s1
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n/an/a 26n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349227
PNG
((4R)-4-methyl-6-[3-(1-methylpyrazol-4-yl)-1H-indaz...)
Show SMILES CN\C=C(/C=N)C(=N)c1cc(ccc1N)-c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C21H24N6O/c1-12-8-19(28)27-18-5-3-4-15(21(18)26-12)13-6-7-17(23)16(9-13)20(24)14(10-22)11-25-2/h3-7,9-12,22,24-26H,8,23H2,1-2H3,(H,27,28)/b14-11+,22-10?,24-20?/t12-/m1/s1
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n/an/a 27n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349273
PNG
((2R)-6-chloro-9-(3-cyclopropyl-1-methyl-indazol-5-...)
Show SMILES CNc1ccc(cc1C(=N)C1CC1)-c1ccc(Cl)c2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C21H23ClN4O/c1-11-9-18(27)26-21-16(22)7-6-14(20(21)25-11)13-5-8-17(24-2)15(10-13)19(23)12-3-4-12/h5-8,10-12,23-25H,3-4,9H2,1-2H3,(H,26,27)/t11-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349485
PNG
(US10206931, Example 293 | methyl-6-(1-)
Show SMILES CN\C=C(/C=N)c1ccc2N(CC[C@@H](C)c2c1)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C24H29N5O/c1-15-9-10-29(21-8-7-17(12-19(15)21)18(13-25)14-26-3)22-6-4-5-20-24(22)27-16(2)11-23(30)28-20/h4-8,12-16,25-27H,9-11H2,1-3H3,(H,28,30)/b18-14+,25-13?/t15-,16-/m1/s1
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n/an/a 35n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349249
PNG
((4R)-6-(1-tert-butyl-3-methyl-indol-2-yl)-4-methyl...)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3c(C)c4ccccc4n3C(C)(C)C)c2N1
Show InChI InChI=1S/C23H27N3O/c1-14-13-20(27)25-18-11-8-10-17(21(18)24-14)22-15(2)16-9-6-7-12-19(16)26(22)23(3,4)5/h6-12,14,24H,13H2,1-5H3,(H,25,27)/t14-/m1/s1
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n/an/a 37n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349490
PNG
(US10206931, Example 298 | methylpyrazol-4-)
Show SMILES CN\C=C(/C=N)c1ccc(Nc2cccc3NC(=O)C[C@@H](C)Nc23)c(F)c1
Show InChI InChI=1S/C20H22FN5O/c1-12-8-19(27)26-18-5-3-4-17(20(18)24-12)25-16-7-6-13(9-15(16)21)14(10-22)11-23-2/h3-7,9-12,22-25H,8H2,1-2H3,(H,26,27)/b14-11+,22-10?/t12-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349253
PNG
((4R)-4-methyl-6-[1-methyl-6-(1-methylpyrazol-4-yl)...)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3cc4ccc(cc4n3C)-c3cnn(C)c3)c2N1
Show InChI InChI=1S/C23H23N5O/c1-14-9-22(29)26-19-6-4-5-18(23(19)25-14)21-11-16-8-7-15(10-20(16)28(21)3)17-12-24-27(2)13-17/h4-8,10-14,25H,9H2,1-3H3,(H,26,29)/t14-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349302
PNG
((4R)-6-(3-cyclopropyl-1-methyl-indazol-5-yl)-4-met...)
Show SMILES CNc1ccc(cc1C(=N)C1CC1)-c1cccc2NC(=O)C[C@H](C)Cc12
Show InChI InChI=1S/C22H25N3O/c1-13-10-17-16(4-3-5-20(17)25-21(26)11-13)15-8-9-19(24-2)18(12-15)22(23)14-6-7-14/h3-5,8-9,12-14,23-24H,6-7,10-11H2,1-2H3,(H,25,26)/t13-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178163
PNG
(CHEMBL3813846 | US10206931, Example 286)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3cccc(OCc4ccccc4)c3)c2N1
Show InChI InChI=1S/C23H22N2O2/c1-16-13-22(26)25-21-12-6-11-20(23(21)24-16)18-9-5-10-19(14-18)27-15-17-7-3-2-4-8-17/h2-12,14,16,24H,13,15H2,1H3,(H,25,26)/t16-/m1/s1
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n/an/a 45n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM349493
PNG
(US10206931, Example 301 | methylpyrazol-4-)
Show SMILES CN\C=C(/C=N)c1ccc2N(CCc2c1)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C22H25N5O/c1-14-10-21(28)26-18-4-3-5-20(22(18)25-14)27-9-8-16-11-15(6-7-19(16)27)17(12-23)13-24-2/h3-7,11-14,23-25H,8-10H2,1-2H3,(H,26,28)/b17-13+,23-12?/t14-/m1/s1
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n/an/a 46n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349279
PNG
((2R)-9-(3-cyclopropyl-1-methyl-indazol-5-yl)-6-met...)
Show SMILES CNc1ccc(cc1C(=N)C1CC1)-c1ccc(OC)c2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C22H26N4O2/c1-12-10-19(27)26-22-18(28-3)9-7-15(21(22)25-12)14-6-8-17(24-2)16(11-14)20(23)13-4-5-13/h6-9,11-13,23-25H,4-5,10H2,1-3H3,(H,26,27)/t12-/m1/s1
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n/an/a 46n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178220
PNG
(CHEMBL3814550 | US10206931, Example 57)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(C5CC5)c4c3)c2N1
Show InChI InChI=1S/C21H22N4O/c1-12-10-19(26)23-17-5-3-4-15(21(17)22-12)14-8-9-18-16(11-14)20(13-6-7-13)24-25(18)2/h3-5,8-9,11-13,22H,6-7,10H2,1-2H3,(H,23,26)/t12-/m1/s1
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n/an/a 49n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM349495
PNG
(US10206931, Example 303 | methylpyrazol-4-)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(N3CCc4ccc(cc34)-c3cnn(C)c3)c2N1
Show InChI InChI=1S/C22H23N5O/c1-14-10-21(28)25-18-4-3-5-19(22(18)24-14)27-9-8-15-6-7-16(11-20(15)27)17-12-23-26(2)13-17/h3-7,11-14,24H,8-10H2,1-2H3,(H,25,28)/t14-/m1/s1
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n/an/a 52n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349283
PNG
((2R)-2-methyl-9-[1- | US10206931, Example 90)
Show SMILES CN\C=C(/C=N)C(=N)c1cc(ccc1NC)-c1cncc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C21H25N7O/c1-12-6-19(29)28-18-11-26-10-16(21(18)27-12)13-4-5-17(25-3)15(7-13)20(23)14(8-22)9-24-2/h4-5,7-12,22-25,27H,6H2,1-3H3,(H,28,29)/b14-9+,22-8?,23-20?/t12-/m1/s1
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n/an/a 52n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349287
PNG
((4R)-4-methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)...)
Show SMILES CN\C=C(/C=N)C(=N)c1cc(ccc1NC)-c1nccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C21H25N7O/c1-12-8-18(29)28-17-6-7-26-20(21(17)27-12)13-4-5-16(25-3)15(9-13)19(23)14(10-22)11-24-2/h4-7,9-12,22-25,27H,8H2,1-3H3,(H,28,29)/b14-11+,22-10?,23-19?/t12-/m1/s1
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n/an/a 54n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349228
PNG
((4R)-6-[1-(2-hydroxyethyl)-3-(1-methylpyrazol-4-yl...)
Show SMILES CN\C=C(/C=N)C(=N)c1cc(ccc1NCCO)-c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C23H28N6O2/c1-14-10-21(31)29-20-5-3-4-17(23(20)28-14)15-6-7-19(27-8-9-30)18(11-15)22(25)16(12-24)13-26-2/h3-7,11-14,24-28,30H,8-10H2,1-2H3,(H,29,31)/b16-13+,24-12?,25-22?/t14-/m1/s1
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n/an/a 57n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349254
PNG
((4R)-4-methyl-6-[1-methyl-7-(1-methylpyrazol-4-yl)...)
Show SMILES CN\C=C(/C=N)c1cccc2cc(-c3cccc4NC(=O)C[C@@H](C)Nc34)n(C)c12
Show InChI InChI=1S/C23H25N5O/c1-14-10-21(29)27-19-9-5-8-18(22(19)26-14)20-11-15-6-4-7-17(23(15)28(20)3)16(12-24)13-25-2/h4-9,11-14,24-26H,10H2,1-3H3,(H,27,29)/b16-13+,24-12?/t14-/m1/s1
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n/an/a 65n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349276
PNG
((4R)-6-(3-cyclopropyl-1-methyl-indazol-5-yl)-4-met...)
Show SMILES CNc1ccc(cc1C(=N)C1CC1)-c1ccc(C#N)c2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C22H23N5O/c1-12-9-19(28)27-21-15(11-23)5-7-16(22(21)26-12)14-6-8-18(25-2)17(10-14)20(24)13-3-4-13/h5-8,10,12-13,24-26H,3-4,9H2,1-2H3,(H,27,28)/t12-/m1/s1
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n/an/a 82n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349280
PNG
((4R)-8-chloro-6-(3-cyclopropyl-1-methyl-indazol-5-...)
Show SMILES CNc1ccc(cc1C(=N)C1CC1)-c1cc(Cl)cc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C21H23ClN4O/c1-11-7-19(27)26-18-10-14(22)9-15(21(18)25-11)13-5-6-17(24-2)16(8-13)20(23)12-3-4-12/h5-6,8-12,23-25H,3-4,7H2,1-2H3,(H,26,27)/t11-/m1/s1
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n/an/a 83n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349358
PNG
((2R)-9-(3-cyclopropyl-1- | US10206931, Example 166)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(C5CC5)c4c3)c2O1
Show InChI InChI=1S/C21H21N3O2/c1-12-10-19(25)22-17-5-3-4-15(21(17)26-12)14-8-9-18-16(11-14)20(13-6-7-13)23-24(18)2/h3-5,8-9,11-13H,6-7,10H2,1-2H3,(H,22,25)/t12-/m1/s1
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n/an/a 86n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349405
PNG
(N-(3-isopropoxyphenyl)- | US10206931, Example 213)
Show SMILES CC(C)Oc1cccc(NC(=O)c2cccc3NC(=O)CC(C)Nc23)c1
Show InChI InChI=1S/C20H23N3O3/c1-12(2)26-15-7-4-6-14(11-15)22-20(25)16-8-5-9-17-19(16)21-13(3)10-18(24)23-17/h4-9,11-13,21H,10H2,1-3H3,(H,22,25)(H,23,24)
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n/an/a 93n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349285
PNG
((4R)-6-(3-cyclopropyl-1-methyl-indazol-5-yl)-8-flu...)
Show SMILES CNc1ccc(cc1C(=N)C1CC1)-c1cc(F)cc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C21H23FN4O/c1-11-7-19(27)26-18-10-14(22)9-15(21(18)25-11)13-5-6-17(24-2)16(8-13)20(23)12-3-4-12/h5-6,8-12,23-25H,3-4,7H2,1-2H3,(H,26,27)/t11-/m1/s1
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n/an/a 98n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349275
PNG
((4R)-6-(3-cyclopropyl-1-methyl-indazol-5-yl)-4,9-d...)
Show SMILES CNc1ccc(cc1C(=N)C1CC1)-c1ccc(C)c2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C22H26N4O/c1-12-4-8-16(22-21(12)26-19(27)10-13(2)25-22)15-7-9-18(24-3)17(11-15)20(23)14-5-6-14/h4,7-9,11,13-14,23-25H,5-6,10H2,1-3H3,(H,26,27)/t13-/m1/s1
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n/an/a 99n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349473
PNG
(US10206931, Example 281 | [(4R)-6-(3-)
Show SMILES CC(C)c1cccc(c1)-c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C19H22N2O/c1-12(2)14-6-4-7-15(11-14)16-8-5-9-17-19(16)20-13(3)10-18(22)21-17/h4-9,11-13,20H,10H2,1-3H3,(H,21,22)/t13-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349261
PNG
(N-(3- | US10206931, Example 68)
Show SMILES CC(C)Oc1cccc(NC(=O)c2cccc3NC(=O)C[C@@H](C)Oc23)c1
Show InChI InChI=1S/C20H22N2O4/c1-12(2)25-15-7-4-6-14(11-15)21-20(24)16-8-5-9-17-19(16)26-13(3)10-18(23)22-17/h4-9,11-13H,10H2,1-3H3,(H,21,24)(H,22,23)/t13-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349292
PNG
(2-methyl-N-(3-oxazol-5- | US10206931, Example 99)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(C(=O)Nc3cccc(c3)-c3cnco3)c2O1
Show InChI InChI=1S/C20H17N3O4/c1-12-8-18(24)23-16-7-3-6-15(19(16)27-12)20(25)22-14-5-2-4-13(9-14)17-10-21-11-26-17/h2-7,9-12H,8H2,1H3,(H,22,25)(H,23,24)/t12-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349416
PNG
((4R)-4-methyl-6-[3- | US10206931, Example 224)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3cccc(c3)C(=N)NN)c2N1
Show InChI InChI=1S/C17H19N5O/c1-10-8-15(23)21-14-7-3-6-13(16(14)20-10)11-4-2-5-12(9-11)17(18)22-19/h2-7,9-10,20H,8,19H2,1H3,(H2,18,22)(H,21,23)/t10-/m1/s1
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n/an/a 102n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349361
PNG
((R,E)-9-((3,4- | US10206931, Example 169)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(\C=C3/CCCc4ccccc34)c2O1
Show InChI InChI=1S/C21H21NO2/c1-14-12-20(23)22-19-11-5-9-17(21(19)24-14)13-16-8-4-7-15-6-2-3-10-18(15)16/h2-3,5-6,9-11,13-14H,4,7-8,12H2,1H3,(H,22,23)/b16-13+/t14-/m1/s1
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n/an/a 106n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349284
PNG
((4R)-6-(3-cyclopropyl-1-methyl-indazol-5-yl)-4-met...)
Show SMILES CNc1ccc(cc1C(=N)C1CC1)-c1cc(cc2NC(=O)C[C@@H](C)Nc12)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O/c1-11-7-19(30)29-18-10-14(22(23,24)25)9-15(21(18)28-11)13-5-6-17(27-2)16(8-13)20(26)12-3-4-12/h5-6,8-12,26-28H,3-4,7H2,1-2H3,(H,29,30)/t11-/m1/s1
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n/an/a 106n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349477
PNG
((4R)-4-methyl-6-(3- | US10206931, Example 285)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3cccc(c3)N3CCOCC3)c2N1
Show InChI InChI=1S/C20H23N3O2/c1-14-12-19(24)22-18-7-3-6-17(20(18)21-14)15-4-2-5-16(13-15)23-8-10-25-11-9-23/h2-7,13-14,21H,8-12H2,1H3,(H,22,24)/t14-/m1/s1
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n/an/a 113n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)

More data for this
Ligand-Target Pair
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