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Patent code US10208011

Compile Data Set for Download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349610
PNG
((3-(4-(2-aminoethyl)phenoxy)-6- hydroxybenzo[b]thi...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(CCN)cc1
Show InChI InChI=1S/C25H22FNO3S/c1-14-11-17(26)12-15(2)22(14)23(29)25-24(20-8-5-18(28)13-21(20)31-25)30-19-6-3-16(4-7-19)9-10-27/h3-8,11-13,28H,9-10,27H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349611
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(2- ...)
Show SMILES CC(C)NCCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C28H28FNO3S/c1-16(2)30-12-11-19-5-8-22(9-6-19)33-27-23-10-7-21(31)15-24(23)34-28(27)26(32)25-17(3)13-20(29)14-18(25)4/h5-10,13-16,30-31H,11-12H2,1-4H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349626
PNG
((4-f1uoro-2,6-dimethylphenyl)(3-(4-(2- (3-(fluorom...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1-c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H27F2NO3S/c1-17-11-21(31)12-18(2)26(17)28(34)29-27(24-8-5-22(33)13-25(24)36-29)20-3-6-23(7-4-20)35-10-9-32-15-19(14-30)16-32/h3-8,11-13,19,33H,9-10,14-16H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349619
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4- ((m...)
Show SMILES CNCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C25H22FNO3S/c1-14-10-17(26)11-15(2)22(14)23(29)25-24(20-9-6-18(28)12-21(20)31-25)30-19-7-4-16(5-8-19)13-27-3/h4-12,27-28H,13H2,1-3H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349606
PNG
((3-(4-(2-(ethylamino)ethyl)phenoxy)-6- hydroxybenz...)
Show SMILES CCNCCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C27H26FNO3S/c1-4-29-12-11-18-5-8-21(9-6-18)32-26-22-10-7-20(30)15-23(22)33-27(26)25(31)24-16(2)13-19(28)14-17(24)3/h5-10,13-15,29-30H,4,11-12H2,1-3H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349627
PNG
((4-fluoro-2,6-dimethylphenyl)(3-(4-(2- (3-(fluorom...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1-c1ccc(OCCN2CCC(CF)C2)cc1
Show InChI InChI=1S/C30H29F2NO3S/c1-18-13-22(32)14-19(2)27(18)29(35)30-28(25-8-5-23(34)15-26(25)37-30)21-3-6-24(7-4-21)36-12-11-33-10-9-20(16-31)17-33/h3-8,13-15,20,34H,9-12,16-17H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349612
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(2-(...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C30H30FNO4S/c1-19-16-21(31)17-20(2)27(19)28(34)30-29(25-11-6-22(33)18-26(25)37-30)36-24-9-7-23(8-10-24)35-15-14-32-12-4-3-5-13-32/h6-11,16-18,33H,3-5,12-15H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349616
PNG
((3-(4-(2- (cyclohexylamino)ethyl)phenoxy)-6- hydro...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(CCNC2CCCCC2)cc1
Show InChI InChI=1S/C31H32FNO3S/c1-19-16-22(32)17-20(2)28(19)29(35)31-30(26-13-10-24(34)18-27(26)37-31)36-25-11-8-21(9-12-25)14-15-33-23-6-4-3-5-7-23/h8-13,16-18,23,33-34H,3-7,14-15H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349618
PNG
((3-(4-(2-(diethylamino)ethyl)phenoxy)-6- hydroxybe...)
Show SMILES CCN(CC)CCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C29H30FNO3S/c1-5-31(6-2)14-13-20-7-10-23(11-8-20)34-28-24-12-9-22(32)17-25(24)35-29(28)27(33)26-18(3)15-21(30)16-19(26)4/h7-12,15-17,32H,5-6,13-14H2,1-4H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349620
PNG
((3-(4-((dimethylamino)methyl)phenoxy)- 6-hydroxybe...)
Show SMILES CN(C)Cc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C26H24FNO3S/c1-15-11-18(27)12-16(2)23(15)24(30)26-25(21-10-7-19(29)13-22(21)32-26)31-20-8-5-17(6-9-20)14-28(3)4/h5-13,29H,14H2,1-4H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349624
PNG
((S)-(4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-...)
Show SMILES C[C@H]1CCN(CCc2ccc(Oc3c(sc4cc(O)ccc34)C(=O)c3c(C)cc(F)cc3C)cc2)C1
Show InChI InChI=1S/C30H30FNO3S/c1-18-10-12-32(17-18)13-11-21-4-7-24(8-5-21)35-29-25-9-6-23(33)16-26(25)36-30(29)28(34)27-19(2)14-22(31)15-20(27)3/h4-9,14-16,18,33H,10-13,17H2,1-3H3/t18-/m0/s1
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349607
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(pip...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C28H26FNO3S/c1-17-14-19(29)15-18(2)25(17)26(32)28-27(23-11-8-21(31)16-24(23)34-28)33-22-9-6-20(7-10-22)30-12-4-3-5-13-30/h6-11,14-16,31H,3-5,12-13H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349607
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(pip...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C28H26FNO3S/c1-17-14-19(29)15-18(2)25(17)26(32)28-27(23-11-8-21(31)16-24(23)34-28)33-22-9-6-20(7-10-22)30-12-4-3-5-13-30/h6-11,14-16,31H,3-5,12-13H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349613
PNG
((3-(4-(2-(azepan-1-yl)ethoxy)phenoxy)- 6-hydroxybe...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CCCCCC2)cc1
Show InChI InChI=1S/C31H32FNO4S/c1-20-17-22(32)18-21(2)28(20)29(35)31-30(26-12-7-23(34)19-27(26)38-31)37-25-10-8-24(9-11-25)36-16-15-33-13-5-3-4-6-14-33/h7-12,17-19,34H,3-6,13-16H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349614
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(2-(...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C29H28FNO4S/c1-18-15-20(30)16-19(2)26(18)27(33)29-28(24-10-5-21(32)17-25(24)36-29)35-23-8-6-22(7-9-23)34-14-13-31-11-3-4-12-31/h5-10,15-17,32H,3-4,11-14H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349615
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(2-(...)
Show SMILES CCC(CC)NCCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C30H32FNO3S/c1-5-22(6-2)32-14-13-20-7-10-24(11-8-20)35-29-25-12-9-23(33)17-26(25)36-30(29)28(34)27-18(3)15-21(31)16-19(27)4/h7-12,15-17,22,32-33H,5-6,13-14H2,1-4H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349622
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(3- ...)
Show SMILES CNCCCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C27H26FNO3S/c1-16-13-19(28)14-17(2)24(16)25(31)27-26(22-11-8-20(30)15-23(22)33-27)32-21-9-6-18(7-10-21)5-4-12-29-3/h6-11,13-15,29-30H,4-5,12H2,1-3H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349625
PNG
((4-fluoro-2,6-dimethylphenyl)(3-(4-(2- (3-(fluorom...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1-c1ccc(CCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H27F2NO2S/c1-17-11-22(31)12-18(2)26(17)28(34)29-27(24-8-7-23(33)13-25(24)35-29)21-5-3-19(4-6-21)9-10-32-15-20(14-30)16-32/h3-8,11-13,20,33H,9-10,14-16H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349608
PNG
((3-(4-(azepan-1-yl)phenoxy)-6- hydroxybenzo[b]thio...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(cc1)N1CCCCCC1
Show InChI InChI=1S/C29H28FNO3S/c1-18-15-20(30)16-19(2)26(18)27(33)29-28(24-12-9-22(32)17-25(24)35-29)34-23-10-7-21(8-11-23)31-13-5-3-4-6-14-31/h7-12,15-17,32H,3-6,13-14H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349608
PNG
((3-(4-(azepan-1-yl)phenoxy)-6- hydroxybenzo[b]thio...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(cc1)N1CCCCCC1
Show InChI InChI=1S/C29H28FNO3S/c1-18-15-20(30)16-19(2)26(18)27(33)29-28(24-12-9-22(32)17-25(24)35-29)34-23-10-7-21(8-11-23)31-13-5-3-4-6-14-31/h7-12,15-17,32H,3-6,13-14H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349614
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(2-(...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C29H28FNO4S/c1-18-15-20(30)16-19(2)26(18)27(33)29-28(24-10-5-21(32)17-25(24)36-29)35-23-8-6-22(7-9-23)34-14-13-31-11-3-4-12-31/h5-10,15-17,32H,3-4,11-14H2,1-2H3
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US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349621
PNG
((3-(4-(aminomethyl)phenoxy)-6- hydroxybenzo[b]thio...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(CN)cc1
Show InChI InChI=1S/C24H20FNO3S/c1-13-9-16(25)10-14(2)21(13)22(28)24-23(19-8-5-17(27)11-20(19)30-24)29-18-6-3-15(12-26)4-7-18/h3-11,27H,12,26H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349623
PNG
((4-fluoro-2,6-dimethylphenyl)(3-(4-(2- (3-(fluorom...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(CCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H27F2NO3S/c1-17-11-21(31)12-18(2)26(17)27(34)29-28(24-8-5-22(33)13-25(24)36-29)35-23-6-3-19(4-7-23)9-10-32-15-20(14-30)16-32/h3-8,11-13,20,33H,9-10,14-16H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349625
PNG
((4-fluoro-2,6-dimethylphenyl)(3-(4-(2- (3-(fluorom...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1-c1ccc(CCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H27F2NO2S/c1-17-11-22(31)12-18(2)26(17)28(34)29-27(24-8-7-23(33)13-25(24)35-29)21-5-3-19(4-6-21)9-10-32-15-20(14-30)16-32/h3-8,11-13,20,33H,9-10,14-16H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349629
PNG
(US10208011, Compound 126 | sodium 1-(2-(4-(2-(4-fl...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc([Na]O)ccc2c1-c1ccc(OCCN2CC(C2)C(=O)O[Na])cc1
Show InChI InChI=1S/C29H25FNO4S.2Na.H2O/c1-17-13-21(30)14-18(2)25(17)27(32)28-26(23-5-3-4-6-24(23)36-28)19-7-9-22(10-8-19)35-12-11-31-15-20(16-31)29(33)34;;;/h3,5-10,13-14,20H,11-12,15-16H2,1-2H3,(H,33,34);;;1H2/q;2*+1;/p-2
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349630
PNG
(US10208011, Compound RAD-)
Show SMILES CCNCCc1ccc(CN(CC)c2cc(OC)ccc2[C@@H]2CCc3cc(O)ccc3C2)cc1
Show InChI InChI=1S/C30H38N2O2/c1-4-31-17-16-22-6-8-23(9-7-22)21-32(5-2)30-20-28(34-3)14-15-29(30)26-11-10-25-19-27(33)13-12-24(25)18-26/h6-9,12-15,19-20,26,31,33H,4-5,10-11,16-18,21H2,1-3H3/t26-/m1/s1
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349610
PNG
((3-(4-(2-aminoethyl)phenoxy)-6- hydroxybenzo[b]thi...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(CCN)cc1
Show InChI InChI=1S/C25H22FNO3S/c1-14-11-17(26)12-15(2)22(14)23(29)25-24(20-8-5-18(28)13-21(20)31-25)30-19-6-3-16(4-7-19)9-10-27/h3-8,11-13,28H,9-10,27H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349615
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(2-(...)
Show SMILES CCC(CC)NCCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C30H32FNO3S/c1-5-22(6-2)32-14-13-20-7-10-24(11-8-20)35-29-25-12-9-23(33)17-26(25)36-30(29)28(34)27-18(3)15-21(31)16-19(27)4/h7-12,15-17,22,32-33H,5-6,13-14H2,1-4H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349617
PNG
((3-(4-(2-(sec- butylamino)ethyl)phenoxy)-6- hydrox...)
Show SMILES CCC(C)NCCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C29H30FNO3S/c1-5-19(4)31-13-12-20-6-9-23(10-7-20)34-28-24-11-8-22(32)16-25(24)35-29(28)27(33)26-17(2)14-21(30)15-18(26)3/h6-11,14-16,19,31-32H,5,12-13H2,1-4H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349620
PNG
((3-(4-((dimethylamino)methyl)phenoxy)- 6-hydroxybe...)
Show SMILES CN(C)Cc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C26H24FNO3S/c1-15-11-18(27)12-16(2)23(15)24(30)26-25(21-10-7-19(29)13-22(21)32-26)31-20-8-5-17(6-9-20)14-28(3)4/h5-13,29H,14H2,1-4H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349624
PNG
((S)-(4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-...)
Show SMILES C[C@H]1CCN(CCc2ccc(Oc3c(sc4cc(O)ccc34)C(=O)c3c(C)cc(F)cc3C)cc2)C1
Show InChI InChI=1S/C30H30FNO3S/c1-18-10-12-32(17-18)13-11-21-4-7-24(8-5-21)35-29-25-9-6-23(33)16-26(25)36-30(29)28(34)27-19(2)14-22(31)15-20(27)3/h4-9,14-16,18,33H,10-13,17H2,1-3H3/t18-/m0/s1
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349612
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(2-(...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C30H30FNO4S/c1-19-16-21(31)17-20(2)27(19)28(34)30-29(25-11-6-22(33)18-26(25)37-30)36-24-9-7-23(8-10-24)35-15-14-32-12-4-3-5-13-32/h6-11,16-18,33H,3-5,12-15H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349613
PNG
((3-(4-(2-(azepan-1-yl)ethoxy)phenoxy)- 6-hydroxybe...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CCCCCC2)cc1
Show InChI InChI=1S/C31H32FNO4S/c1-20-17-22(32)18-21(2)28(20)29(35)31-30(26-12-7-23(34)19-27(26)38-31)37-25-10-8-24(9-11-25)36-16-15-33-13-5-3-4-6-14-33/h7-12,17-19,34H,3-6,13-16H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349618
PNG
((3-(4-(2-(diethylamino)ethyl)phenoxy)-6- hydroxybe...)
Show SMILES CCN(CC)CCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C29H30FNO3S/c1-5-31(6-2)14-13-20-7-10-23(11-8-20)34-28-24-12-9-22(32)17-25(24)35-29(28)27(33)26-18(3)15-21(30)16-19(26)4/h7-12,15-17,32H,5-6,13-14H2,1-4H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349629
PNG
(US10208011, Compound 126 | sodium 1-(2-(4-(2-(4-fl...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc([Na]O)ccc2c1-c1ccc(OCCN2CC(C2)C(=O)O[Na])cc1
Show InChI InChI=1S/C29H25FNO4S.2Na.H2O/c1-17-13-21(30)14-18(2)25(17)27(32)28-26(23-5-3-4-6-24(23)36-28)19-7-9-22(10-8-19)35-12-11-31-15-20(16-31)29(33)34;;;/h3,5-10,13-14,20H,11-12,15-16H2,1-2H3,(H,33,34);;;1H2/q;2*+1;/p-2
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349606
PNG
((3-(4-(2-(ethylamino)ethyl)phenoxy)-6- hydroxybenz...)
Show SMILES CCNCCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C27H26FNO3S/c1-4-29-12-11-18-5-8-21(9-6-18)32-26-22-10-7-20(30)15-23(22)33-27(26)25(31)24-16(2)13-19(28)14-17(24)3/h5-10,13-15,29-30H,4,11-12H2,1-3H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349616
PNG
((3-(4-(2- (cyclohexylamino)ethyl)phenoxy)-6- hydro...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(CCNC2CCCCC2)cc1
Show InChI InChI=1S/C31H32FNO3S/c1-19-16-22(32)17-20(2)28(19)29(35)31-30(26-13-10-24(34)18-27(26)37-31)36-25-11-8-21(9-12-25)14-15-33-23-6-4-3-5-7-23/h8-13,16-18,23,33-34H,3-7,14-15H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349617
PNG
((3-(4-(2-(sec- butylamino)ethyl)phenoxy)-6- hydrox...)
Show SMILES CCC(C)NCCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C29H30FNO3S/c1-5-19(4)31-13-12-20-6-9-23(10-7-20)34-28-24-11-8-22(32)16-25(24)35-29(28)27(33)26-17(2)14-21(30)15-18(26)3/h6-11,14-16,19,31-32H,5,12-13H2,1-4H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349619
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4- ((m...)
Show SMILES CNCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C25H22FNO3S/c1-14-10-17(26)11-15(2)22(14)23(29)25-24(20-9-6-18(28)12-21(20)31-25)30-19-7-4-16(5-8-19)13-27-3/h4-12,27-28H,13H2,1-3H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349621
PNG
((3-(4-(aminomethyl)phenoxy)-6- hydroxybenzo[b]thio...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(CN)cc1
Show InChI InChI=1S/C24H20FNO3S/c1-13-9-16(25)10-14(2)21(13)22(28)24-23(19-8-5-17(27)11-20(19)30-24)29-18-6-3-15(12-26)4-7-18/h3-11,27H,12,26H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349622
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(3- ...)
Show SMILES CNCCCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C27H26FNO3S/c1-16-13-19(28)14-17(2)24(16)25(31)27-26(22-11-8-20(30)15-23(22)33-27)32-21-9-6-18(7-10-21)5-4-12-29-3/h6-11,13-15,29-30H,4-5,12H2,1-3H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349623
PNG
((4-fluoro-2,6-dimethylphenyl)(3-(4-(2- (3-(fluorom...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(CCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H27F2NO3S/c1-17-11-21(31)12-18(2)26(17)27(34)29-28(24-8-5-22(33)13-25(24)36-29)35-23-6-3-19(4-7-23)9-10-32-15-20(14-30)16-32/h3-8,11-13,20,33H,9-10,14-16H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349628
PNG
((4-fluoro-2,6-dimethylphenyl)(3-(4-(2- (4-(fluorom...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1-c1ccc(OCCN2CCC(CF)CC2)cc1
Show InChI InChI=1S/C31H31F2NO3S/c1-19-15-23(33)16-20(2)28(19)30(36)31-29(26-8-5-24(35)17-27(26)38-31)22-3-6-25(7-4-22)37-14-13-34-11-9-21(18-32)10-12-34/h3-8,15-17,21,35H,9-14,18H2,1-2H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349630
PNG
(US10208011, Compound RAD-)
Show SMILES CCNCCc1ccc(CN(CC)c2cc(OC)ccc2[C@@H]2CCc3cc(O)ccc3C2)cc1
Show InChI InChI=1S/C30H38N2O2/c1-4-31-17-16-22-6-8-23(9-7-22)21-32(5-2)30-20-28(34-3)14-15-29(30)26-11-10-25-19-27(33)13-12-24(25)18-26/h6-9,12-15,19-20,26,31,33H,4-5,10-11,16-18,21H2,1-3H3/t26-/m1/s1
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n/an/a<1.00E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349609
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(pip...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(cc1)C1CCCNC1
Show InChI InChI=1S/C28H26FNO3S/c1-16-12-20(29)13-17(2)25(16)26(32)28-27(23-10-7-21(31)14-24(23)34-28)33-22-8-5-18(6-9-22)19-4-3-11-30-15-19/h5-10,12-14,19,30-31H,3-4,11,15H2,1-2H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349611
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(2- ...)
Show SMILES CC(C)NCCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Show InChI InChI=1S/C28H28FNO3S/c1-16(2)30-12-11-19-5-8-22(9-6-19)33-27-23-10-7-21(31)15-24(23)34-28(27)26(32)25-17(3)13-20(29)14-18(25)4/h5-10,13-16,30-31H,11-12H2,1-4H3
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n/an/a<5.00E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349609
PNG
((4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(pip...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(cc1)C1CCCNC1
Show InChI InChI=1S/C28H26FNO3S/c1-16-12-20(29)13-17(2)25(16)26(32)28-27(23-10-7-21(31)14-24(23)34-28)33-22-8-5-18(6-9-22)19-4-3-11-30-15-19/h5-10,12-14,19,30-31H,3-4,11,15H2,1-2H3
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n/an/a<5.00E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349628
PNG
((4-fluoro-2,6-dimethylphenyl)(3-(4-(2- (4-(fluorom...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1-c1ccc(OCCN2CCC(CF)CC2)cc1
Show InChI InChI=1S/C31H31F2NO3S/c1-19-15-23(33)16-20(2)28(19)30(36)31-29(26-8-5-24(35)17-27(26)38-31)22-3-6-25(7-4-22)37-14-13-34-11-9-21(18-32)10-12-34/h3-8,15-17,21,35H,9-14,18H2,1-2H3
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n/an/a<5.00E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349626
PNG
((4-f1uoro-2,6-dimethylphenyl)(3-(4-(2- (3-(fluorom...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1-c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H27F2NO3S/c1-17-11-21(31)12-18(2)26(17)28(34)29-27(24-8-5-22(33)13-25(24)36-29)20-3-6-23(7-4-20)35-10-9-32-15-19(14-30)16-32/h3-8,11-13,19,33H,9-10,14-16H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))
BDBM349627
PNG
((4-fluoro-2,6-dimethylphenyl)(3-(4-(2- (3-(fluorom...)
Show SMILES Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1-c1ccc(OCCN2CCC(CF)C2)cc1
Show InChI InChI=1S/C30H29F2NO3S/c1-18-13-22(32)14-19(2)27(18)29(35)30-28(25-8-5-23(34)15-26(25)37-30)21-3-6-24(7-4-21)36-12-11-33-10-9-20(16-31)17-33/h3-8,13-15,20,34H,9-12,16-17H2,1-2H3
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G1 Therapeutics, Inc.

US Patent


Assay Description
All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...


US Patent US10208011 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%