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Patent code US10208023

Compile Data Set for Download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM350000
PNG
((S)-(4,6-bis(trifluoromethyl)-1H- benzo[d]imidazol...)
Show SMILES N[C@H](c1nc2cc(cc(c2n1)C(F)(F)F)C(F)(F)F)c1ccc(Cl)cc1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 312n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 SLOW INACTIVATION BLOCK (nM) (Manual Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349999
PNG
((2R)-2-amino-N-(2-(3,5- bis(trifluoromethyl)phenox...)
Show SMILES CC(C)C[C@@H](N)C(=O)NC(COc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C22H24F6N2O2/c1-13(2)8-18(29)20(31)30-19(14-6-4-3-5-7-14)12-32-17-10-15(21(23,24)25)9-16(11-17)22(26,27)28/h3-7,9-11,13,18-19H,8,12,29H2,1-2H3,(H,30,31)/t18-,19?/m1/s1
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 436n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 SLOW INACTIVATION BLOCK (nM) (Manual Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349995
PNG
((R)-2-amino-N-((S)-1-(3,5- bis(trifluoromethyl)phe...)
Show SMILES CC(C)C[C@@H](N)C(=O)N[C@@H](C)COc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H22F6N2O2/c1-9(2)4-14(24)15(26)25-10(3)8-27-13-6-11(16(18,19)20)5-12(7-13)17(21,22)23/h5-7,9-10,14H,4,8,24H2,1-3H3,(H,25,26)/t10-,14+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 568n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 SLOW INACTIVATION BLOCK (nM) (Manual Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349996
PNG
((2R)-2-amino-N-(1-(3,5- bis(trifluoromethyl)phenox...)
Show SMILES CC(C)C[C@@H](N)C(=O)NC(C)COc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H22F6N2O2/c1-9(2)4-14(24)15(26)25-10(3)8-27-13-6-11(16(18,19)20)5-12(7-13)17(21,22)23/h5-7,9-10,14H,4,8,24H2,1-3H3,(H,25,26)/t10?,14-/m1/s1
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 1.66E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 INWARD CURRENT BLOCK (nM) (Automated Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349997
PNG
(2-amino-N-((S)-1-(3,5- bis(trifluoromethyl)phenoxy...)
Show SMILES CC(C)CC(N)C(=O)N[C@@H](C)COc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H22F6N2O2/c1-9(2)4-14(24)15(26)25-10(3)8-27-13-6-11(16(18,19)20)5-12(7-13)17(21,22)23/h5-7,9-10,14H,4,8,24H2,1-3H3,(H,25,26)/t10-,14?/m0/s1
PDB

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UniChem
US Patent
n/an/a 1.89E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 INWARD CURRENT BLOCK (nM) (Automated Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349995
PNG
((R)-2-amino-N-((S)-1-(3,5- bis(trifluoromethyl)phe...)
Show SMILES CC(C)C[C@@H](N)C(=O)N[C@@H](C)COc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H22F6N2O2/c1-9(2)4-14(24)15(26)25-10(3)8-27-13-6-11(16(18,19)20)5-12(7-13)17(21,22)23/h5-7,9-10,14H,4,8,24H2,1-3H3,(H,25,26)/t10-,14+/m0/s1
PDB

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UniChem
US Patent
n/an/a 2.58E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 SLOW INACTIVATION BLOCK (nM) (Automated Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349996
PNG
((2R)-2-amino-N-(1-(3,5- bis(trifluoromethyl)phenox...)
Show SMILES CC(C)C[C@@H](N)C(=O)NC(C)COc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H22F6N2O2/c1-9(2)4-14(24)15(26)25-10(3)8-27-13-6-11(16(18,19)20)5-12(7-13)17(21,22)23/h5-7,9-10,14H,4,8,24H2,1-3H3,(H,25,26)/t10?,14-/m1/s1
PDB

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UniChem
US Patent
n/an/a 2.77E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 SLOW INACTIVATION BLOCK (nM) (Automated Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM350000
PNG
((S)-(4,6-bis(trifluoromethyl)-1H- benzo[d]imidazol...)
Show SMILES N[C@H](c1nc2cc(cc(c2n1)C(F)(F)F)C(F)(F)F)c1ccc(Cl)cc1
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 2.89E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 SLOW INACTIVATION BLOCK (nM) (Automated Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349998
PNG
((R)-N-(2-(3-fluoro-5- (trifluoromethyl)phenoxy)eth...)
Show SMILES CN[C@H](CC(C)C)C(=O)NCCOc1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H22F4N2O2/c1-10(2)6-14(21-3)15(23)22-4-5-24-13-8-11(16(18,19)20)7-12(17)9-13/h7-10,14,21H,4-6H2,1-3H3,(H,22,23)/t14-/m1/s1
PDB

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US Patent
n/an/a 3.50E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 SLOW INACTIVATION BLOCK (nM) (Manual Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349997
PNG
(2-amino-N-((S)-1-(3,5- bis(trifluoromethyl)phenoxy...)
Show SMILES CC(C)CC(N)C(=O)N[C@@H](C)COc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H22F6N2O2/c1-9(2)4-14(24)15(26)25-10(3)8-27-13-6-11(16(18,19)20)5-12(7-13)17(21,22)23/h5-7,9-10,14H,4,8,24H2,1-3H3,(H,25,26)/t10-,14?/m0/s1
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 4.12E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 SLOW INACTIVATION BLOCK (nM) (Automated Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349999
PNG
((2R)-2-amino-N-(2-(3,5- bis(trifluoromethyl)phenox...)
Show SMILES CC(C)C[C@@H](N)C(=O)NC(COc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C22H24F6N2O2/c1-13(2)8-18(29)20(31)30-19(14-6-4-3-5-7-14)12-32-17-10-15(21(23,24)25)9-16(11-17)22(26,27)28/h3-7,9-11,13,18-19H,8,12,29H2,1-2H3,(H,30,31)/t18-,19?/m1/s1
PDB

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UniChem
US Patent
n/an/a 5.32E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 SLOW INACTIVATION BLOCK (nM) (Automated Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349998
PNG
((R)-N-(2-(3-fluoro-5- (trifluoromethyl)phenoxy)eth...)
Show SMILES CN[C@H](CC(C)C)C(=O)NCCOc1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H22F4N2O2/c1-10(2)6-14(21-3)15(23)22-4-5-24-13-8-11(16(18,19)20)7-12(17)9-13/h7-10,14,21H,4-6H2,1-3H3,(H,22,23)/t14-/m1/s1
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 8.12E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 SLOW INACTIVATION BLOCK (nM) (Automated Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349998
PNG
((R)-N-(2-(3-fluoro-5- (trifluoromethyl)phenoxy)eth...)
Show SMILES CN[C@H](CC(C)C)C(=O)NCCOc1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H22F4N2O2/c1-10(2)6-14(21-3)15(23)22-4-5-24-13-8-11(16(18,19)20)7-12(17)9-13/h7-10,14,21H,4-6H2,1-3H3,(H,22,23)/t14-/m1/s1
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 9.62E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 INWARD CURRENT BLOCK (nM) (Automated Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349999
PNG
((2R)-2-amino-N-(2-(3,5- bis(trifluoromethyl)phenox...)
Show SMILES CC(C)C[C@@H](N)C(=O)NC(COc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C22H24F6N2O2/c1-13(2)8-18(29)20(31)30-19(14-6-4-3-5-7-14)12-32-17-10-15(21(23,24)25)9-16(11-17)22(26,27)28/h3-7,9-11,13,18-19H,8,12,29H2,1-2H3,(H,30,31)/t18-,19?/m1/s1
PDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 1.03E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
In some cases, the potency of compounds was measured using either the Patchliner automated patch clamp platform (Nanion) or manual patch clamp techni...


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349997
PNG
(2-amino-N-((S)-1-(3,5- bis(trifluoromethyl)phenoxy...)
Show SMILES CC(C)CC(N)C(=O)N[C@@H](C)COc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H22F6N2O2/c1-9(2)4-14(24)15(26)25-10(3)8-27-13-6-11(16(18,19)20)5-12(7-13)17(21,22)23/h5-7,9-10,14H,4,8,24H2,1-3H3,(H,25,26)/t10-,14?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 1.15E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
In some cases, the potency of compounds was measured using either the Patchliner automated patch clamp platform (Nanion) or manual patch clamp techni...


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349996
PNG
((2R)-2-amino-N-(1-(3,5- bis(trifluoromethyl)phenox...)
Show SMILES CC(C)C[C@@H](N)C(=O)NC(C)COc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H22F6N2O2/c1-9(2)4-14(24)15(26)25-10(3)8-27-13-6-11(16(18,19)20)5-12(7-13)17(21,22)23/h5-7,9-10,14H,4,8,24H2,1-3H3,(H,25,26)/t10?,14-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.27E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
In some cases, the potency of compounds was measured using either the Patchliner automated patch clamp platform (Nanion) or manual patch clamp techni...


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349998
PNG
((R)-N-(2-(3-fluoro-5- (trifluoromethyl)phenoxy)eth...)
Show SMILES CN[C@H](CC(C)C)C(=O)NCCOc1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H22F4N2O2/c1-10(2)6-14(21-3)15(23)22-4-5-24-13-8-11(16(18,19)20)7-12(17)9-13/h7-10,14,21H,4-6H2,1-3H3,(H,22,23)/t14-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
In some cases, the potency of compounds was measured using either the Patchliner automated patch clamp platform (Nanion) or manual patch clamp techni...


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM350001
PNG
((R)-2-amino-N-((4,6- bis(trifluoromethyl)-1H- benz...)
Show SMILES N[C@H](Cc1cccc(c1)C(F)(F)F)C(=O)NCc1nc2cc(cc(c2n1)C(F)(F)F)C(F)(F)F
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
In some cases, the potency of compounds was measured using either the Patchliner automated patch clamp platform (Nanion) or manual patch clamp techni...


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM350001
PNG
((R)-2-amino-N-((4,6- bis(trifluoromethyl)-1H- benz...)
Show SMILES N[C@H](Cc1cccc(c1)C(F)(F)F)C(=O)NCc1nc2cc(cc(c2n1)C(F)(F)F)C(F)(F)F
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 SLOW INACTIVATION BLOCK (nM) (Automated Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM350001
PNG
((R)-2-amino-N-((4,6- bis(trifluoromethyl)-1H- benz...)
Show SMILES N[C@H](Cc1cccc(c1)C(F)(F)F)C(=O)NCc1nc2cc(cc(c2n1)C(F)(F)F)C(F)(F)F
PDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 1.50E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 INWARD CURRENT BLOCK (nM) (Automated Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349998
PNG
((R)-N-(2-(3-fluoro-5- (trifluoromethyl)phenoxy)eth...)
Show SMILES CN[C@H](CC(C)C)C(=O)NCCOc1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H22F4N2O2/c1-10(2)6-14(21-3)15(23)22-4-5-24-13-8-11(16(18,19)20)7-12(17)9-13/h7-10,14,21H,4-6H2,1-3H3,(H,22,23)/t14-/m1/s1
PDB

KEGG

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UniChem
US Patent
n/an/a 1.50E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 INWARD CURRENT BLOCK (nM) (0.25HZ Automated Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349995
PNG
((R)-2-amino-N-((S)-1-(3,5- bis(trifluoromethyl)phe...)
Show SMILES CC(C)C[C@@H](N)C(=O)N[C@@H](C)COc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H22F6N2O2/c1-9(2)4-14(24)15(26)25-10(3)8-27-13-6-11(16(18,19)20)5-12(7-13)17(21,22)23/h5-7,9-10,14H,4,8,24H2,1-3H3,(H,25,26)/t10-,14+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 1.55E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
In some cases, the potency of compounds was measured using either the Patchliner automated patch clamp platform (Nanion) or manual patch clamp techni...


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM349998
PNG
((R)-N-(2-(3-fluoro-5- (trifluoromethyl)phenoxy)eth...)
Show SMILES CN[C@H](CC(C)C)C(=O)NCCOc1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H22F4N2O2/c1-10(2)6-14(21-3)15(23)22-4-5-24-13-8-11(16(18,19)20)7-12(17)9-13/h7-10,14,21H,4-6H2,1-3H3,(H,22,23)/t14-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 2.32E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
NAV1.7 INWARD CURRENT BLOCK (nM) (7HZ Manual Patchclamp).


US Patent US10208023 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%