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Patent code US10208024

Compile Data Set for Download or QSAR

Found 246 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350052
PNG
(US10208024, Example 51)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1cc(C)c(=O)n(n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H34N8O4/c1-18-11-24(33-36(28(18)37)21-12-22(39-3)14-23(13-21)40-4)26-27(29)30-16-25(32-26)19-15-31-35(17-19)20-5-7-34(8-6-20)9-10-38-2/h11-17,20H,5-10H2,1-4H3,(H2,29,30)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350059
PNG
(US10208024, Example 58)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H25Cl2N7O3/c1-36-19-10-20(37-2)23(27)24(22(19)26)34-21(35)4-3-18(32-34)17-9-14(11-30-25(17)28)15-12-31-33(13-15)16-5-7-29-8-6-16/h3-4,9-13,16,29H,5-8H2,1-2H3,(H2,28,30)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350042
PNG
(US10208024, Example 41)
Show SMILES COc1cc(OC)c(F)c(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H25FN8O3/c1-35-16-9-19(22(25)20(10-16)36-2)33-21(34)4-3-17(31-33)23-24(26)28-12-18(30-23)14-11-29-32(13-14)15-5-7-27-8-6-15/h3-4,9-13,15,27H,5-8H2,1-2H3,(H2,26,28)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350051
PNG
(US10208024, Example 50)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H28N8O3/c1-15-8-21(31-33(25(15)34)18-9-19(35-2)11-20(10-18)36-3)23-24(26)28-13-22(30-23)16-12-29-32(14-16)17-4-6-27-7-5-17/h8-14,17,27H,4-7H2,1-3H3,(H2,26,28)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350049
PNG
(6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N7O3/c1-29-12-14(10-26-29)20-11-25-22(24)21(27-20)19-9-18(13-4-5-13)23(31)30(28-19)15-6-16(32-2)8-17(7-15)33-3/h6-13H,4-5H2,1-3H3,(H2,24,25)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350052
PNG
(US10208024, Example 51)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1cc(C)c(=O)n(n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H34N8O4/c1-18-11-24(33-36(28(18)37)21-12-22(39-3)14-23(13-21)40-4)26-27(29)30-16-25(32-26)19-15-31-35(17-19)20-5-7-34(8-6-20)9-10-38-2/h11-17,20H,5-10H2,1-4H3,(H2,29,30)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350082
PNG
(US10208024, Example 81)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H29N7O3/c1-16-8-24(31-33(26(16)34)20-10-21(35-2)12-22(11-20)36-3)23-9-17(13-29-25(23)27)18-14-30-32(15-18)19-4-6-28-7-5-19/h8-15,19,28H,4-7H2,1-3H3,(H2,27,29)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350050
PNG
(6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CCC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C24H25N7O3/c1-30-13-15(11-27-30)21-12-26-23(25)22(28-21)20-10-19(14-5-4-6-14)24(32)31(29-20)16-7-17(33-2)9-18(8-16)34-3/h7-14H,4-6H2,1-3H3,(H2,25,26)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350033
PNG
(US10208024, Example 32)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCN(C)CC1
Show InChI InChI=1S/C25H28N8O3/c1-31-8-6-17(7-9-31)32-15-16(13-28-32)22-14-27-25(26)24(29-22)21-4-5-23(34)33(30-21)18-10-19(35-2)12-20(11-18)36-3/h4-5,10-15,17H,6-9H2,1-3H3,(H2,26,27)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350043
PNG
(US10208024, Example 42)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1cc(OC)cc(OC)c1F
Show InChI InChI=1S/C27H31FN8O4/c1-38-11-10-34-8-6-18(7-9-34)35-16-17(14-31-35)21-15-30-27(29)26(32-21)20-4-5-24(37)36(33-20)22-12-19(39-2)13-23(40-3)25(22)28/h4-5,12-16,18H,6-11H2,1-3H3,(H2,29,30)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350032
PNG
(US10208024, Example 31)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H26N8O3/c1-34-18-9-17(10-19(11-18)35-2)32-22(33)4-3-20(30-32)23-24(25)27-13-21(29-23)15-12-28-31(14-15)16-5-7-26-8-6-16/h3-4,9-14,16,26H,5-8H2,1-2H3,(H2,25,27)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350049
PNG
(6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N7O3/c1-29-12-14(10-26-29)20-11-25-22(24)21(27-20)19-9-18(13-4-5-13)23(31)30(28-19)15-6-16(32-2)8-17(7-15)33-3/h6-13H,4-5H2,1-3H3,(H2,24,25)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350045
PNG
(US10208024, Example 44)
Show SMILES CCc1cc(nn(-c2cc(OC)cc(OC)c2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N7O3/c1-5-13-6-18(20-21(23)24-11-19(26-20)14-10-25-28(2)12-14)27-29(22(13)30)15-7-16(31-3)9-17(8-15)32-4/h6-12H,5H2,1-4H3,(H2,23,24)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350061
PNG
(US10208024, Example 60)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1ccc(N)c(c1)-c1ccc(=O)n(n1)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C29H32Cl2N6O4/c1-39-13-12-35-10-8-20(9-11-35)36-17-19(16-33-36)18-4-5-22(32)21(14-18)23-6-7-26(38)37(34-23)29-27(30)24(40-2)15-25(41-3)28(29)31/h4-7,14-17,20H,8-13,32H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350048
PNG
(US10208024, Example 47)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C(C)C)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N7O3/c1-13(2)18-9-19(21-22(24)25-11-20(27-21)14-10-26-29(3)12-14)28-30(23(18)31)15-6-16(32-4)8-17(7-15)33-5/h6-13H,1-5H3,(H2,24,25)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350015
PNG
(6-(3-amino-6-(1- methyl-1H-pyrazol-4- yl)pyrazin-2...)
Show SMILES COc1cc(OC)c(Cl)c(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C20H18ClN7O3/c1-27-10-11(8-24-27)14-9-23-20(22)19(25-14)13-4-5-17(29)28(26-13)15-6-12(30-2)7-16(31-3)18(15)21/h4-10H,1-3H3,(H2,22,23)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350048
PNG
(US10208024, Example 47)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C(C)C)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N7O3/c1-13(2)18-9-19(21-22(24)25-11-20(27-21)14-10-26-29(3)12-14)28-30(23(18)31)15-6-16(32-4)8-17(7-15)33-5/h6-13H,1-5H3,(H2,24,25)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350044
PNG
(US10208024, Example 43)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C21H21N7O3/c1-12-5-17(19-20(22)23-10-18(25-19)13-9-24-27(2)11-13)26-28(21(12)29)14-6-15(30-3)8-16(7-14)31-4/h5-11H,1-4H3,(H2,22,23)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350015
PNG
(6-(3-amino-6-(1- methyl-1H-pyrazol-4- yl)pyrazin-2...)
Show SMILES COc1cc(OC)c(Cl)c(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C20H18ClN7O3/c1-27-10-11(8-24-27)14-9-23-20(22)19(25-14)13-4-5-17(29)28(26-13)15-6-12(30-2)7-16(31-3)18(15)21/h4-10H,1-3H3,(H2,22,23)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350044
PNG
(US10208024, Example 43)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C21H21N7O3/c1-12-5-17(19-20(22)23-10-18(25-19)13-9-24-27(2)11-13)26-28(21(12)29)14-6-15(30-3)8-16(7-14)31-4/h5-11H,1-4H3,(H2,22,23)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350034
PNG
(US10208024, Example 33)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C27H32N8O4/c1-37-11-10-33-8-6-19(7-9-33)34-17-18(15-30-34)24-16-29-27(28)26(31-24)23-4-5-25(36)35(32-23)20-12-21(38-2)14-22(13-20)39-3/h4-5,12-17,19H,6-11H2,1-3H3,(H2,28,29)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350051
PNG
(US10208024, Example 50)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H28N8O3/c1-15-8-21(31-33(25(15)34)18-9-19(35-2)11-20(10-18)36-3)23-24(26)28-13-22(30-23)16-12-29-32(14-16)17-4-6-27-7-5-17/h8-14,17,27H,4-7H2,1-3H3,(H2,26,28)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350025
PNG
(US10208024, Example 24)
Show SMILES COc1cc(OC)c(Br)c(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C20H18BrN7O3/c1-27-10-11(8-24-27)14-9-23-20(22)19(25-14)13-4-5-17(29)28(26-13)15-6-12(30-2)7-16(31-3)18(15)21/h4-10H,1-3H3,(H2,22,23)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350033
PNG
(US10208024, Example 32)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCN(C)CC1
Show InChI InChI=1S/C25H28N8O3/c1-31-8-6-17(7-9-31)32-15-16(13-28-32)22-14-27-25(26)24(29-22)21-4-5-23(34)33(30-21)18-10-19(35-2)12-20(11-18)36-3/h4-5,10-15,17H,6-9H2,1-3H3,(H2,26,27)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350028
PNG
(US10208024, Example 27)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C[C@@H]2CNC(C)(C)CO2)c1
Show InChI InChI=1S/C26H30N8O4/c1-26(2)15-38-20(11-29-26)14-33-13-16(10-30-33)22-12-28-25(27)24(31-22)21-5-6-23(35)34(32-21)17-7-18(36-3)9-19(8-17)37-4/h5-10,12-13,20,29H,11,14-15H2,1-4H3,(H2,27,28)/t20-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350050
PNG
(6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CCC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C24H25N7O3/c1-30-13-15(11-27-30)21-12-26-23(25)22(28-21)20-10-19(14-5-4-6-14)24(32)31(29-20)16-7-17(33-2)9-18(8-16)34-3/h7-14H,4-6H2,1-3H3,(H2,25,26)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350020
PNG
(US10208024, Example 19)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CCN2CCOCC2)c1
Show InChI InChI=1S/C25H28N8O4/c1-35-19-11-18(12-20(13-19)36-2)33-23(34)4-3-21(30-33)24-25(26)27-15-22(29-24)17-14-28-32(16-17)6-5-31-7-9-37-10-8-31/h3-4,11-16H,5-10H2,1-2H3,(H2,26,27)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350083
PNG
(US10208024, Example 82)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C27H30F2N8O4/c1-39-11-10-35-8-6-17(7-9-35)36-15-16(13-32-36)19-14-31-27(30)25(33-19)18-4-5-22(38)37(34-18)26-23(28)20(40-2)12-21(41-3)24(26)29/h4-5,12-15,17H,6-11H2,1-3H3,(H2,30,31)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350027
PNG
(US10208024, Example 26)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C[C@H]2CNC(C)(C)CO2)c1
Show InChI InChI=1S/C26H30N8O4/c1-26(2)15-38-20(11-29-26)14-33-13-16(10-30-33)22-12-28-25(27)24(31-22)21-5-6-23(35)34(32-21)17-7-18(36-3)9-19(8-17)37-4/h5-10,12-13,20,29H,11,14-15H2,1-4H3,(H2,27,28)/t20-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350029
PNG
(US10208024, Example 28)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C[C@@H]2CN[C@H](C)CO2)c1
Show InChI InChI=1S/C25H28N8O4/c1-15-14-37-20(10-27-15)13-32-12-16(9-29-32)22-11-28-25(26)24(30-22)21-4-5-23(34)33(31-21)17-6-18(35-2)8-19(7-17)36-3/h4-9,11-12,15,20,27H,10,13-14H2,1-3H3,(H2,26,28)/t15-,20+/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350005
PNG
(1-((4-(5-amino-6-(1- (3,5- dimethoxyphenyl)-6- oxo...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2(CC2)C#N)c1
Show InChI InChI=1S/C24H22N8O3/c1-34-17-7-16(8-18(9-17)35-2)32-21(33)4-3-19(30-32)22-23(26)27-11-20(29-22)15-10-28-31(12-15)14-24(13-25)5-6-24/h3-4,7-12H,5-6,14H2,1-2H3,(H2,26,27)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM350083
PNG
(US10208024, Example 82)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C27H30F2N8O4/c1-39-11-10-35-8-6-17(7-9-35)36-15-16(13-32-36)19-14-31-27(30)25(33-19)18-4-5-22(38)37(34-18)26-23(28)20(40-2)12-21(41-3)24(26)29/h4-5,12-15,17H,6-11H2,1-3H3,(H2,30,31)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350059
PNG
(US10208024, Example 58)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H25Cl2N7O3/c1-36-19-10-20(37-2)23(27)24(22(19)26)34-21(35)4-3-18(32-34)17-9-14(11-30-25(17)28)15-12-31-33(13-15)16-5-7-29-8-6-16/h3-4,9-13,16,29H,5-8H2,1-2H3,(H2,28,30)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350005
PNG
(1-((4-(5-amino-6-(1- (3,5- dimethoxyphenyl)-6- oxo...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2(CC2)C#N)c1
Show InChI InChI=1S/C24H22N8O3/c1-34-17-7-16(8-18(9-17)35-2)32-21(33)4-3-19(30-32)22-23(26)27-11-20(29-22)15-10-28-31(12-15)14-24(13-25)5-6-24/h3-4,7-12H,5-6,14H2,1-2H3,(H2,26,27)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350020
PNG
(US10208024, Example 19)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CCN2CCOCC2)c1
Show InChI InChI=1S/C25H28N8O4/c1-35-19-11-18(12-20(13-19)36-2)33-23(34)4-3-21(30-33)24-25(26)27-15-22(29-24)17-14-28-32(16-17)6-5-31-7-9-37-10-8-31/h3-4,11-16H,5-10H2,1-2H3,(H2,26,27)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350024
PNG
(US10208024, Example 23)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C20H17Cl2N7O3/c1-28-9-10(7-25-28)12-8-24-20(23)18(26-12)11-4-5-15(30)29(27-11)19-16(21)13(31-2)6-14(32-3)17(19)22/h4-9H,1-3H3,(H2,23,24)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350006
PNG
(6-(3-amino-6-(1- (4,4,4-trifluoro-2- hydroxybutyl)...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC(O)CC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N7O4/c1-36-16-5-14(6-17(7-16)37-2)33-20(35)4-3-18(31-33)21-22(27)28-10-19(30-21)13-9-29-32(11-13)12-15(34)8-23(24,25)26/h3-7,9-11,15,34H,8,12H2,1-2H3,(H2,27,28)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350031
PNG
(US10208024, Example 30)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C[C@H]2CN[C@H](C)CO2)c1
Show InChI InChI=1S/C25H28N8O4/c1-15-14-37-20(10-27-15)13-32-12-16(9-29-32)22-11-28-25(26)24(30-22)21-4-5-23(34)33(31-21)17-6-18(35-2)8-19(7-17)36-3/h4-9,11-12,15,20,27H,10,13-14H2,1-3H3,(H2,26,28)/t15-,20-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350041
PNG
(US10208024, Example 40)
Show SMILES COc1ccc(F)c(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C23H23FN8O2/c1-34-16-2-3-17(24)20(10-16)32-21(33)5-4-18(30-32)22-23(25)27-12-19(29-22)14-11-28-31(13-14)15-6-8-26-9-7-15/h2-5,10-13,15,26H,6-9H2,1H3,(H2,25,27)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350066
PNG
(US10208024, Example 65)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C[C@@H]2CN(C)C(C)(C)CO2)c1
Show InChI InChI=1S/C27H32N8O4/c1-27(2)16-39-21(14-33(27)3)15-34-13-17(11-30-34)23-12-29-26(28)25(31-23)22-6-7-24(36)35(32-22)18-8-19(37-4)10-20(9-18)38-5/h6-13,21H,14-16H2,1-5H3,(H2,28,29)/t21-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM350042
PNG
(US10208024, Example 41)
Show SMILES COc1cc(OC)c(F)c(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H25FN8O3/c1-35-16-9-19(22(25)20(10-16)36-2)33-21(34)4-3-17(31-33)23-24(26)28-12-18(30-23)14-11-29-32(13-14)15-5-7-27-8-6-15/h3-4,9-13,15,27H,5-8H2,1-2H3,(H2,26,28)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350083
PNG
(US10208024, Example 82)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C27H30F2N8O4/c1-39-11-10-35-8-6-17(7-9-35)36-15-16(13-32-36)19-14-31-27(30)25(33-19)18-4-5-22(38)37(34-18)26-23(28)20(40-2)12-21(41-3)24(26)29/h4-5,12-15,17H,6-11H2,1-3H3,(H2,30,31)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM350049
PNG
(6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N7O3/c1-29-12-14(10-26-29)20-11-25-22(24)21(27-20)19-9-18(13-4-5-13)23(31)30(28-19)15-6-16(32-2)8-17(7-15)33-3/h6-13H,4-5H2,1-3H3,(H2,24,25)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM350042
PNG
(US10208024, Example 41)
Show SMILES COc1cc(OC)c(F)c(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H25FN8O3/c1-35-16-9-19(22(25)20(10-16)36-2)33-21(34)4-3-17(31-33)23-24(26)28-12-18(30-23)14-11-29-32(13-14)15-5-7-27-8-6-15/h3-4,9-13,15,27H,5-8H2,1-2H3,(H2,26,28)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350036
PNG
(US10208024, Example 35)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCN(CC(F)F)CC1
Show InChI InChI=1S/C26H28F2N8O3/c1-38-19-9-18(10-20(11-19)39-2)36-24(37)4-3-21(33-36)25-26(29)30-13-22(32-25)16-12-31-35(14-16)17-5-7-34(8-6-17)15-23(27)28/h3-4,9-14,17,23H,5-8,15H2,1-2H3,(H2,29,30)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350006
PNG
(6-(3-amino-6-(1- (4,4,4-trifluoro-2- hydroxybutyl)...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC(O)CC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N7O4/c1-36-16-5-14(6-17(7-16)37-2)33-20(35)4-3-18(31-33)21-22(27)28-10-19(30-21)13-9-29-32(11-13)12-15(34)8-23(24,25)26/h3-7,9-11,15,34H,8,12H2,1-2H3,(H2,27,28)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350002
PNG
(US10208024, Example 1)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C20H19N7O3/c1-26-11-12(9-23-26)17-10-22-20(21)19(24-17)16-4-5-18(28)27(25-16)13-6-14(29-2)8-15(7-13)30-3/h4-11H,1-3H3,(H2,21,22)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM350051
PNG
(US10208024, Example 50)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H28N8O3/c1-15-8-21(31-33(25(15)34)18-9-19(35-2)11-20(10-18)36-3)23-24(26)28-13-22(30-23)16-12-29-32(14-16)17-4-6-27-7-5-17/h8-14,17,27H,4-7H2,1-3H3,(H2,26,28)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM350082
PNG
(US10208024, Example 81)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H29N7O3/c1-16-8-24(31-33(26(16)34)20-10-21(35-2)12-22(11-20)36-3)23-9-17(13-29-25(23)27)18-14-30-32(15-18)19-4-6-28-7-5-19/h8-15,19,28H,4-7H2,1-3H3,(H2,27,29)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350035
PNG
(US10208024, Example 34)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCN(CCOC(F)(F)F)CC1
Show InChI InChI=1S/C27H29F3N8O4/c1-40-20-11-19(12-21(13-20)41-2)38-24(39)4-3-22(35-38)25-26(31)32-15-23(34-25)17-14-33-37(16-17)18-5-7-36(8-6-18)9-10-42-27(28,29)30/h3-4,11-16,18H,5-10H2,1-2H3,(H2,31,32)
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Array BioPharma Inc.

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%