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Patent code US10208039

Compile Data Set for Download or QSAR
Found 147 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347117
PNG
(2-(4-((4-isopropylphenyl)(1-methyl piperidin-3-yl)...)
Show SMILES CC(C)c1ccc(cc1)N(C1CCCN(C)C1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C28H31N5O2/c1-19(2)20-6-8-21(9-7-20)33(23-5-4-16-32(3)18-23)22-10-12-24(13-11-22)35-28-30-26-17-29-15-14-25(26)27(34)31-28/h6-15,17,19,23H,4-5,16,18H2,1-3H3,(H,30,31,34)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347122
PNG
(2-(4-(5-methyl-1H-indol-1-yl)phenoxy) pyrido[3,4-d...)
Show SMILES Cc1ccc2n(ccc2c1)-c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C22H16N4O2/c1-14-2-7-20-15(12-14)9-11-26(20)16-3-5-17(6-4-16)28-22-24-19-13-23-10-8-18(19)21(27)25-22/h2-13H,1H3,(H,24,25,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347131
PNG
(2-(4-((3-(4-ethylpiperazin-1-yl) phenyl)(methyl)am...)
Show SMILES CCN1CCN(CC1)c1cccc(c1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C26H28N6O2/c1-3-31-13-15-32(16-14-31)21-6-4-5-20(17-21)30(2)19-7-9-22(10-8-19)34-26-28-24-18-27-12-11-23(24)25(33)29-26/h4-12,17-18H,3,13-16H2,1-2H3,(H,28,29,33)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347132
PNG
(2-(4-(methyl(3-(1-methyl-1,2,3,6- tetrahydropyridi...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)C1=CCN(C)CC1
Show InChI InChI=1S/C26H25N5O2/c1-30-14-11-18(12-15-30)19-4-3-5-21(16-19)31(2)20-6-8-22(9-7-20)33-26-28-24-17-27-13-10-23(24)25(32)29-26/h3-11,13,16-17H,12,14-15H2,1-2H3,(H,28,29,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347137
PNG
(2-(4-((4-ethylphenyl)(methyl)amino)-3- methylpheno...)
Show SMILES CCc1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1C
Show InChI InChI=1S/C23H22N4O2/c1-4-16-5-7-17(8-6-16)27(3)21-10-9-18(13-15(21)2)29-23-25-20-14-24-12-11-19(20)22(28)26-23/h5-14H,4H2,1-3H3,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM350231
PNG
(2-(4-((2-methoxy-5-(4-methyl- piperazin-1-yl) phen...)
Show SMILES COc1ccc(cc1N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1)N1CCN(C)CC1
Show InChI InChI=1S/C26H28N6O3/c1-30-12-14-32(15-13-30)19-6-9-24(34-3)23(16-19)31(2)18-4-7-20(8-5-18)35-26-28-22-17-27-11-10-21(22)25(33)29-26/h4-11,16-17H,12-15H2,1-3H3,(H,28,29,33)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296107
PNG
(2-{4-[(5-isopropyl-pyridin-2-yl)-methyl- amino]-ph...)
Show SMILES CC(C)c1ccc(nc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C22H21N5O2/c1-14(2)15-4-9-20(24-12-15)27(3)16-5-7-17(8-6-16)29-22-25-19-13-23-11-10-18(19)21(28)26-22/h4-14H,1-3H3,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296110
PNG
(2-(4-{[4-(2-amino-1-methyl-ethyl)-phenyl] - methyl...)
Show SMILES CC(CN)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C23H23N5O2/c1-15(13-24)16-3-5-17(6-4-16)28(2)18-7-9-19(10-8-18)30-23-26-21-14-25-12-11-20(21)22(29)27-23/h3-12,14-15H,13,24H2,1-2H3,(H,26,27,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296181
PNG
(2-(1-piperidin-4-ylindol-5- yl)oxypyrido[3,4-d]pyr...)
Show SMILES Oc1nc(Oc2ccc3n(ccc3c2)C2CCNCC2)nc2cnccc12
Show InChI InChI=1S/C20H19N5O2/c26-19-16-5-9-22-12-17(16)23-20(24-19)27-15-1-2-18-13(11-15)6-10-25(18)14-3-7-21-8-4-14/h1-2,5-6,9-12,14,21H,3-4,7-8H2,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347119
PNG
(2-(4-((4-isopropylphenyl) (pyrrolidin-3-yl)amino)p...)
Show SMILES CC(C)c1ccc(cc1)N(C1CCNC1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C26H27N5O2/c1-17(2)18-3-5-19(6-4-18)31(21-11-13-27-15-21)20-7-9-22(10-8-20)33-26-29-24-16-28-14-12-23(24)25(32)30-26/h3-10,12,14,16-17,21,27H,11,13,15H2,1-2H3,(H,29,30,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347121
PNG
(2-(4-(5-methylindolin-1-yl)phenoxy pyrido[3,4-d]py...)
Show SMILES Cc1ccc2N(CCc2c1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C22H18N4O2/c1-14-2-7-20-15(12-14)9-11-26(20)16-3-5-17(6-4-16)28-22-24-19-13-23-10-8-18(19)21(27)25-22/h2-8,10,12-13H,9,11H2,1H3,(H,24,25,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296095
PNG
(2-(4-{methyl-[3-(4-methyl-piperazin-1-yl)- phenyl]...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)N1CCN(C)CC1
Show InChI InChI=1S/C25H26N6O2/c1-29-12-14-31(15-13-29)20-5-3-4-19(16-20)30(2)18-6-8-21(9-7-18)33-25-27-23-17-26-11-10-22(23)24(32)28-25/h3-11,16-17H,12-15H2,1-2H3,(H,27,28,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296114
PNG
(2-(4-{methyl-[3-(4-methyl-piperazin-1- ylmethyl)-p...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(CN2CCN(C)CC2)c1
Show InChI InChI=1S/C26H28N6O2/c1-30-12-14-32(15-13-30)18-19-4-3-5-21(16-19)31(2)20-6-8-22(9-7-20)34-26-28-24-17-27-11-10-23(24)25(33)29-26/h3-11,16-17H,12-15,18H2,1-2H3,(H,28,29,33)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296146
PNG
(2-[4-[N-methyl-4-[1-(methylamino)propan- 2-yl]anil...)
Show SMILES CNCC(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C24H25N5O2/c1-16(14-25-2)17-4-6-18(7-5-17)29(3)19-8-10-20(11-9-19)31-24-27-22-15-26-13-12-21(22)23(30)28-24/h4-13,15-16,25H,14H2,1-3H3,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296167
PNG
(2-[4-[N,3-dimethyl-5-(4-methylpiperazin-1- yl)anil...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cc(C)cc(c1)N1CCN(C)CC1
Show InChI InChI=1S/C26H28N6O2/c1-18-14-20(16-21(15-18)32-12-10-30(2)11-13-32)31(3)19-4-6-22(7-5-19)34-26-28-24-17-27-9-8-23(24)25(33)29-26/h4-9,14-17H,10-13H2,1-3H3,(H,28,29,33)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296119
PNG
(2-[4-[4-(dimethylamino)-N- methylanilino]phenoxy]p...)
Show SMILES CN(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C22H21N5O2/c1-26(2)15-4-6-16(7-5-15)27(3)17-8-10-18(11-9-17)29-22-24-20-14-23-13-12-19(20)21(28)25-22/h4-14H,1-3H3,(H,24,25,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296125
PNG
(2-[4-[3-(4-aminopiperidin-1-yl)-N- methylanilino]p...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)N1CCC(N)CC1
Show InChI InChI=1S/C25H26N6O2/c1-30(19-3-2-4-20(15-19)31-13-10-17(26)11-14-31)18-5-7-21(8-6-18)33-25-28-23-16-27-12-9-22(23)24(32)29-25/h2-9,12,15-17H,10-11,13-14,26H2,1H3,(H,28,29,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296134
PNG
(2-[4-[3-(3-aminopiperidin-1-yl)-N- methylanilino]p...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)N1CCCC(N)C1
Show InChI InChI=1S/C25H26N6O2/c1-30(19-5-2-6-20(14-19)31-13-3-4-17(26)16-31)18-7-9-21(10-8-18)33-25-28-23-15-27-12-11-22(23)24(32)29-25/h2,5-12,14-15,17H,3-4,13,16,26H2,1H3,(H,28,29,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296095
PNG
(2-(4-{methyl-[3-(4-methyl-piperazin-1-yl)- phenyl]...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)N1CCN(C)CC1
Show InChI InChI=1S/C25H26N6O2/c1-29-12-14-31(15-13-29)20-5-3-4-19(16-20)30(2)18-6-8-21(9-7-18)33-25-27-23-17-26-11-10-22(23)24(32)28-25/h3-11,16-17H,12-15H2,1-2H3,(H,27,28,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347135
PNG
(2-(4-((cyclopropylmethyl)(3-(4-methyl piperazin-1-...)
Show SMILES CN1CCN(CC1)c1cccc(c1)N(CC1CC1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C28H30N6O2/c1-32-13-15-33(16-14-32)22-3-2-4-23(17-22)34(19-20-5-6-20)21-7-9-24(10-8-21)36-28-30-26-18-29-12-11-25(26)27(35)31-28/h2-4,7-12,17-18,20H,5-6,13-16,19H2,1H3,(H,30,31,35)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM350233
PNG
(2-(4-(methyl(2-methyl-5-(4- methylpiperazin-1-yl)p...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cc(ccc1C)N1CCN(C)CC1
Show InChI InChI=1S/C26H28N6O2/c1-18-4-5-20(32-14-12-30(2)13-15-32)16-24(18)31(3)19-6-8-21(9-7-19)34-26-28-23-17-27-11-10-22(23)25(33)29-26/h4-11,16-17H,12-15H2,1-3H3,(H,28,29,33)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296101
PNG
(2-{4-[methyl-(1,2,3,4-tetrahydro- naphthalen-1-ylm...)
Show SMILES CN(CC1CCCc2ccccc12)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C25H24N4O2/c1-29(16-18-7-4-6-17-5-2-3-8-21(17)18)19-9-11-20(12-10-19)31-25-27-23-15-26-14-13-22(23)24(30)28-25/h2-3,5,8-15,18H,4,6-7,16H2,1H3,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296148
PNG
(2-[4-[N-methyl-4-[4-(methylamino)butan- 2-yl]anili...)
Show SMILES CNCCC(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C25H27N5O2/c1-17(12-14-26-2)18-4-6-19(7-5-18)30(3)20-8-10-21(11-9-20)32-25-28-23-16-27-15-13-22(23)24(31)29-25/h4-11,13,15-17,26H,12,14H2,1-3H3,(H,28,29,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296177
PNG
(2-[4-[4-[1-(2-methoxyethylamino)propan-2- yl]-N-me...)
Show SMILES COCCNCC(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C26H29N5O3/c1-18(16-28-14-15-33-3)19-4-6-20(7-5-19)31(2)21-8-10-22(11-9-21)34-26-29-24-17-27-13-12-23(24)25(32)30-26/h4-13,17-18,28H,14-16H2,1-3H3,(H,29,30,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347120
PNG
(2-(4-((4-isopropylphenyl) (1-methylpyrrolidin-3-yl...)
Show SMILES CC(C)c1ccc(cc1)N(C1CCN(C)C1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C27H29N5O2/c1-18(2)19-4-6-20(7-5-19)32(22-13-15-31(3)17-22)21-8-10-23(11-9-21)34-27-29-25-16-28-14-12-24(25)26(33)30-27/h4-12,14,16,18,22H,13,15,17H2,1-3H3,(H,29,30,33)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347123
PNG
(2-(4-((4-isopropylphenyl) (piperidin-3-yl)amino)ph...)
Show SMILES CC(C)c1ccc(cc1)N(C1CCCNC1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C27H29N5O2/c1-18(2)19-5-7-20(8-6-19)32(22-4-3-14-28-16-22)21-9-11-23(12-10-21)34-27-30-25-17-29-15-13-24(25)26(33)31-27/h5-13,15,17-18,22,28H,3-4,14,16H2,1-2H3,(H,30,31,33)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347127
PNG
(2-(3-methyl-4-(methyl(3-(4-methyl- piperazin-1-yl)...)
Show SMILES CN(c1cccc(c1)N1CCN(C)CC1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1C
Show InChI InChI=1S/C26H28N6O2/c1-18-15-21(34-26-28-23-17-27-10-9-22(23)25(33)29-26)7-8-24(18)31(3)19-5-4-6-20(16-19)32-13-11-30(2)12-14-32/h4-10,15-17H,11-14H2,1-3H3,(H,28,29,33)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347134
PNG
(2-(4-(ethyl(3-(4-methylpiperazin-1- yl)phenyl)amin...)
Show SMILES CCN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)N1CCN(C)CC1
Show InChI InChI=1S/C26H28N6O2/c1-3-32(21-6-4-5-20(17-21)31-15-13-30(2)14-16-31)19-7-9-22(10-8-19)34-26-28-24-18-27-12-11-23(24)25(33)29-26/h4-12,17-18H,3,13-16H2,1-2H3,(H,28,29,33)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296141
PNG
(2-[4-[3-[2-(dimethylamino)ethoxy]-4-ethyl- N-methy...)
Show SMILES CCc1ccc(cc1OCCN(C)C)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C26H29N5O3/c1-5-18-6-7-20(16-24(18)33-15-14-30(2)3)31(4)19-8-10-21(11-9-19)34-26-28-23-17-27-13-12-22(23)25(32)29-26/h6-13,16-17H,5,14-15H2,1-4H3,(H,28,29,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296166
PNG
(2-[4-[N-methyl-3-[methyl-(1- methylpiperidin-4- yl...)
Show SMILES CN(C1CCN(C)CC1)c1cccc(c1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C27H30N6O2/c1-31-15-12-20(13-16-31)33(3)22-6-4-5-21(17-22)32(2)19-7-9-23(10-8-19)35-27-29-25-18-28-14-11-24(25)26(34)30-27/h4-11,14,17-18,20H,12-13,15-16H2,1-3H3,(H,29,30,34)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347112
PNG
(2-(4-((4-isopropylphenyl)(1-methyl piperidin-4-yl)...)
Show SMILES CC(C)c1ccc(cc1)N(C1CCN(C)CC1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C28H31N5O2/c1-19(2)20-4-6-21(7-5-20)33(23-13-16-32(3)17-14-23)22-8-10-24(11-9-22)35-28-30-26-18-29-15-12-25(26)27(34)31-28/h4-12,15,18-19,23H,13-14,16-17H2,1-3H3,(H,30,31,34)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347114
PNG
(2-(4-((4-isopropylphenyl)amino) phenoxy)pyrido[3,4...)
Show SMILES CC(C)c1ccc(Nc2ccc(Oc3nc(O)c4ccncc4n3)cc2)cc1
Show InChI InChI=1S/C22H20N4O2/c1-14(2)15-3-5-16(6-4-15)24-17-7-9-18(10-8-17)28-22-25-20-13-23-12-11-19(20)21(27)26-22/h3-14,24H,1-2H3,(H,25,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347125
PNG
(2-(4-((3-(4-isopropylpiperazin-1- yl)phenyl)(methy...)
Show SMILES CC(C)N1CCN(CC1)c1cccc(c1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C27H30N6O2/c1-19(2)32-13-15-33(16-14-32)22-6-4-5-21(17-22)31(3)20-7-9-23(10-8-20)35-27-29-25-18-28-12-11-24(25)26(34)30-27/h4-12,17-19H,13-16H2,1-3H3,(H,29,30,34)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM350232
PNG
(2-(4-((2-ethoxy-5-(4-methylpiperazin- 1-yl) phenyl...)
Show SMILES CCOc1ccc(cc1N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1)N1CCN(C)CC1
Show InChI InChI=1S/C27H30N6O3/c1-4-35-25-10-7-20(33-15-13-31(2)14-16-33)17-24(25)32(3)19-5-8-21(9-6-19)36-27-29-23-18-28-12-11-22(23)26(34)30-27/h5-12,17-18H,4,13-16H2,1-3H3,(H,29,30,34)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296136
PNG
(2-[4-[4-ethyl-N-methyl-3-(4- methylpiperazin-1- yl...)
Show SMILES CCc1ccc(cc1N1CCN(C)CC1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C27H30N6O2/c1-4-19-5-6-21(17-25(19)33-15-13-31(2)14-16-33)32(3)20-7-9-22(10-8-20)35-27-29-24-18-28-12-11-23(24)26(34)30-27/h5-12,17-18H,4,13-16H2,1-3H3,(H,29,30,34)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296137
PNG
(2-[4-[methyl-(2-morpholin-4-ylpyridin-4- yl)amino]...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccnc(c1)N1CCOCC1
Show InChI InChI=1S/C23H22N6O3/c1-28(17-6-9-25-21(14-17)29-10-12-31-13-11-29)16-2-4-18(5-3-16)32-23-26-20-15-24-8-7-19(20)22(30)27-23/h2-9,14-15H,10-13H2,1H3,(H,26,27,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347129
PNG
(-(4-(methyl(3-(4-methylpiperazin-1-yl)-4- (2,2,2-t...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(OCC(F)(F)F)c(c1)N1CCN(C)CC1
Show InChI InChI=1S/C27H27F3N6O3/c1-34-11-13-36(14-12-34)23-15-19(5-8-24(23)38-17-27(28,29)30)35(2)18-3-6-20(7-4-18)39-26-32-22-16-31-10-9-21(22)25(37)33-26/h3-10,15-16H,11-14,17H2,1-2H3,(H,32,33,37)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347133
PNG
(2-(4-(methyl(3-(1-methylpiperidin-4- yl)phenyl)ami...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)C1CCN(C)CC1
Show InChI InChI=1S/C26H27N5O2/c1-30-14-11-18(12-15-30)19-4-3-5-21(16-19)31(2)20-6-8-22(9-7-20)33-26-28-24-17-27-13-10-23(24)25(32)29-26/h3-10,13,16-18H,11-12,14-15H2,1-2H3,(H,28,29,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296165
PNG
(2-[4-[N-methyl-3-(4-methyl-1,4-diazepan- 1-yl)anil...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)N1CCCN(C)CC1
Show InChI InChI=1S/C26H28N6O2/c1-30-13-4-14-32(16-15-30)21-6-3-5-20(17-21)31(2)19-7-9-22(10-8-19)34-26-28-24-18-27-12-11-23(24)25(33)29-26/h3,5-12,17-18H,4,13-16H2,1-2H3,(H,28,29,33)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296182
PNG
(2-[4-[N,4-dimethyl-3-(4-methylpiperazin-1- yl)anil...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(C)c(c1)N1CCN(C)CC1
Show InChI InChI=1S/C26H28N6O2/c1-18-4-5-20(16-24(18)32-14-12-30(2)13-15-32)31(3)19-6-8-21(9-7-19)34-26-28-23-17-27-11-10-22(23)25(33)29-26/h4-11,16-17H,12-15H2,1-3H3,(H,28,29,33)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296190
PNG
(2-(4-{[4-(3-dimethylamino-1-methyl- propyl)-phenyl...)
Show SMILES CC(CCN(C)C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C26H29N5O2/c1-18(14-16-30(2)3)19-5-7-20(8-6-19)31(4)21-9-11-22(12-10-21)33-26-28-24-17-27-15-13-23(24)25(32)29-26/h5-13,15,17-18H,14,16H2,1-4H3,(H,28,29,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347126
PNG
(2-(4-(methyl(3-(4-methylpiperazin-1- yl)phenyl)ami...)
Show SMILES CN(c1cccc(c1)N1CCN(C)CC1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1C(F)(F)F
Show InChI InChI=1S/C26H25F3N6O2/c1-33-10-12-35(13-11-33)18-5-3-4-17(14-18)34(2)23-7-6-19(15-21(23)26(27,28)29)37-25-31-22-16-30-9-8-20(22)24(36)32-25/h3-9,14-16H,10-13H2,1-2H3,(H,31,32,36)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296135
PNG
(2-[4-(4-ethyl-N-methyl-3-morpholin-4- ylanilino)ph...)
Show SMILES CCc1ccc(cc1N1CCOCC1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C26H27N5O3/c1-3-18-4-5-20(16-24(18)31-12-14-33-15-13-31)30(2)19-6-8-21(9-7-19)34-26-28-23-17-27-11-10-22(23)25(32)29-26/h4-11,16-17H,3,12-15H2,1-2H3,(H,28,29,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296147
PNG
(2-[4-[4-(4-aminobutan-2-yl)-N- methylanilino]pheno...)
Show SMILES CC(CCN)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C24H25N5O2/c1-16(11-13-25)17-3-5-18(6-4-17)29(2)19-7-9-20(10-8-19)31-24-27-22-15-26-14-12-21(22)23(30)28-24/h3-10,12,14-16H,11,13,25H2,1-2H3,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296091
PNG
(2-{4-[methyl-(4-morpholin-4-yl-phenyl)- amino]-phe...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C24H23N5O3/c1-28(17-2-4-19(5-3-17)29-12-14-31-15-13-29)18-6-8-20(9-7-18)32-24-26-22-16-25-11-10-21(22)23(30)27-24/h2-11,16H,12-15H2,1H3,(H,26,27,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296122
PNG
(2-[4-[3-(dimethylamino)-N- methylanilino]phenoxy]p...)
Show SMILES CN(C)c1cccc(c1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C22H21N5O2/c1-26(2)16-5-4-6-17(13-16)27(3)15-7-9-18(10-8-15)29-22-24-20-14-23-12-11-19(20)21(28)25-22/h4-14H,1-3H3,(H,24,25,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296123
PNG
(2-[4-(N-methyl-3-pyrrolidin-1- ylanilino)phenoxy]p...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)N1CCCC1
Show InChI InChI=1S/C24H23N5O2/c1-28(18-5-4-6-19(15-18)29-13-2-3-14-29)17-7-9-20(10-8-17)31-24-26-22-16-25-12-11-21(22)23(30)27-24/h4-12,15-16H,2-3,13-14H2,1H3,(H,26,27,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296127
PNG
(2-[4-[methyl-[(1S)-1- phenylethyl]amino]phenoxy]py...)
Show SMILES C[C@H](N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccccc1
Show InChI InChI=1S/C22H20N4O2/c1-15(16-6-4-3-5-7-16)26(2)17-8-10-18(11-9-17)28-22-24-20-14-23-13-12-19(20)21(27)25-22/h3-15H,1-2H3,(H,24,25,27)/t15-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296131
PNG
(2-[4-(N,4-dimethyl-3-morpholin-4- ylanilino)phenox...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(C)c(c1)N1CCOCC1
Show InChI InChI=1S/C25H25N5O3/c1-17-3-4-19(15-23(17)30-11-13-32-14-12-30)29(2)18-5-7-20(8-6-18)33-25-27-22-16-26-10-9-21(22)24(31)28-25/h3-10,15-16H,11-14H2,1-2H3,(H,27,28,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296138
PNG
(2-[4-[2,3-dihydro-1H-inden-1- ylmethyl(methyl)amin...)
Show SMILES CN(CC1CCc2ccccc12)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C24H22N4O2/c1-28(15-17-7-6-16-4-2-3-5-20(16)17)18-8-10-19(11-9-18)30-24-26-22-14-25-13-12-21(22)23(29)27-24/h2-5,8-14,17H,6-7,15H2,1H3,(H,26,27,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296140
PNG
(2-[4-[4-(2-hydroxypropan-2-yl)-N- methylanilino]ph...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)C(C)(C)O
Show InChI InChI=1S/C23H22N4O3/c1-23(2,29)15-4-6-16(7-5-15)27(3)17-8-10-18(11-9-17)30-22-25-20-14-24-13-12-19(20)21(28)26-22/h4-14,29H,1-3H3,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296073
PNG
(2-[4-(methyl-pyridin-2-yl-amino)- phenoxy]-pyrido[...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccccn1
Show InChI InChI=1S/C19H15N5O2/c1-24(17-4-2-3-10-21-17)13-5-7-14(8-6-13)26-19-22-16-12-20-11-9-15(16)18(25)23-19/h2-12H,1H3,(H,22,23,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296075
PNG
(2-(1-phenethyl-1H-indol-5-yloxy)- pyrido[3,4-d]pyr...)
Show SMILES Oc1nc(Oc2ccc3n(CCc4ccccc4)ccc3c2)nc2cnccc12
Show InChI InChI=1S/C23H18N4O2/c28-22-19-8-11-24-15-20(19)25-23(26-22)29-18-6-7-21-17(14-18)10-13-27(21)12-9-16-4-2-1-3-5-16/h1-8,10-11,13-15H,9,12H2,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296085
PNG
(2-{4-[methyl(2- phenylethyl)amino]phenoxy}pyridino...)
Show SMILES CN(CCc1ccccc1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C22H20N4O2/c1-26(14-12-16-5-3-2-4-6-16)17-7-9-18(10-8-17)28-22-24-20-15-23-13-11-19(20)21(27)25-22/h2-11,13,15H,12,14H2,1H3,(H,24,25,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296090
PNG
(2-{4-[(3-methoxy-phenyl)-methyl-amino]- phenoxy}-p...)
Show SMILES COc1cccc(c1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C21H18N4O3/c1-25(15-4-3-5-17(12-15)27-2)14-6-8-16(9-7-14)28-21-23-19-13-22-11-10-18(19)20(26)24-21/h3-13H,1-2H3,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296100
PNG
(2-{4-[methyl-(5-morpholin-4-yl-pyridin-3- yl)-amin...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cncc(c1)N1CCOCC1
Show InChI InChI=1S/C23H22N6O3/c1-28(17-12-18(14-25-13-17)29-8-10-31-11-9-29)16-2-4-19(5-3-16)32-23-26-21-15-24-7-6-20(21)22(30)27-23/h2-7,12-15H,8-11H2,1H3,(H,26,27,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296133
PNG
(2-[4-(N-methyl-4- methylsulfonylanilino)phenoxy]py...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H18N4O4S/c1-25(15-5-9-17(10-6-15)30(2,27)28)14-3-7-16(8-4-14)29-21-23-19-13-22-12-11-18(19)20(26)24-21/h3-13H,1-2H3,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296149
PNG
(2-[4-[N-methyl-4-(2,2,2- trifluoroethoxy)anilino]p...)
Show SMILES CN(c1ccc(OCC(F)(F)F)cc1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C22H17F3N4O3/c1-29(14-2-6-16(7-3-14)31-13-22(23,24)25)15-4-8-17(9-5-15)32-21-27-19-12-26-11-10-18(19)20(30)28-21/h2-12H,13H2,1H3,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296169
PNG
(2-[4-(4-tert-butyl-N- methylanilino)phenoxy]pyrido...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C24H24N4O2/c1-24(2,3)16-5-7-17(8-6-16)28(4)18-9-11-19(12-10-18)30-23-26-21-15-25-14-13-20(21)22(29)27-23/h5-15H,1-4H3,(H,26,27,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296174
PNG
(2-[4-[(5-ethylpyridin-2-yl)- methylamino]phenoxy]p...)
Show SMILES CCc1ccc(nc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C21H19N5O2/c1-3-14-4-9-19(23-12-14)26(2)15-5-7-16(8-6-15)28-21-24-18-13-22-11-10-17(18)20(27)25-21/h4-13H,3H2,1-2H3,(H,24,25,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296176
PNG
(2-[4-[N-methyl-4-(oxan-4- yl)anilino]phenoxy]pyrid...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)C1CCOCC1
Show InChI InChI=1S/C25H24N4O3/c1-29(19-4-2-17(3-5-19)18-11-14-31-15-12-18)20-6-8-21(9-7-20)32-25-27-23-16-26-13-10-22(23)24(30)28-25/h2-10,13,16,18H,11-12,14-15H2,1H3,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296185
PNG
(2-[4-[N-methyl-4-(1,1,1-trifluoropropan-2- yl)anil...)
Show SMILES CC(c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1)C(F)(F)F
Show InChI InChI=1S/C23H19F3N4O2/c1-14(23(24,25)26)15-3-5-16(6-4-15)30(2)17-7-9-18(10-8-17)32-22-28-20-13-27-12-11-19(20)21(31)29-22/h3-14H,1-2H3,(H,28,29,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296084
PNG
(2-(2-benzyl-2H-indazol-6-yloxy)- pyrido[3,4-d]pyri...)
Show SMILES Oc1nc(Oc2ccc3cn(Cc4ccccc4)nc3c2)nc2cnccc12
Show InChI InChI=1S/C21H15N5O2/c27-20-17-8-9-22-11-19(17)23-21(24-20)28-16-7-6-15-13-26(25-18(15)10-16)12-14-4-2-1-3-5-14/h1-11,13H,12H2,(H,23,24,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296087
PNG
(2-(1-benzyl-1H-indazol-5-yloxy)- pyridino[3,4-d]py...)
Show SMILES Oc1nc(Oc2ccc3n(Cc4ccccc4)ncc3c2)nc2cnccc12
Show InChI InChI=1S/C21H15N5O2/c27-20-17-8-9-22-12-18(17)24-21(25-20)28-16-6-7-19-15(10-16)11-23-26(19)13-14-4-2-1-3-5-14/h1-12H,13H2,(H,24,25,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296096
PNG
(2-(4-{[4-(4-amino-piperidin-1-yl)-phenyl]- methyl-...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)N1CCC(N)CC1
Show InChI InChI=1S/C25H26N6O2/c1-30(18-2-4-20(5-3-18)31-14-11-17(26)12-15-31)19-6-8-21(9-7-19)33-25-28-23-16-27-13-10-22(23)24(32)29-25/h2-10,13,16-17H,11-12,14-15,26H2,1H3,(H,28,29,32)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296097
PNG
(N-[4-(4-hydroxy-pyrido[3,4-d]pyrimidin-2- yloxy)-p...)
Show SMILES CN(C(=O)Cc1ccccc1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C22H18N4O3/c1-26(20(27)13-15-5-3-2-4-6-15)16-7-9-17(10-8-16)29-22-24-19-14-23-12-11-18(19)21(28)25-22/h2-12,14H,13H2,1H3,(H,24,25,28)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296132
PNG
(2-[4-(N-methyl-3- methylsulfonylanilino)phenoxy]py...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C21H18N4O4S/c1-25(15-4-3-5-17(12-15)30(2,27)28)14-6-8-16(9-7-14)29-21-23-19-13-22-11-10-18(19)20(26)24-21/h3-13H,1-2H3,(H,23,24,26)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296168
PNG
(2-[1-(oxan-4-yl)indol-5-yl]oxypyrido[3,4- d]pyrimi...)
Show SMILES Oc1nc(Oc2ccc3n(ccc3c2)C2CCOCC2)nc2cnccc12
Show InChI InChI=1S/C20H18N4O3/c25-19-16-3-7-21-12-17(16)22-20(23-19)27-15-1-2-18-13(11-15)4-8-24(18)14-5-9-26-10-6-14/h1-4,7-8,11-12,14H,5-6,9-10H2,(H,22,23,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296076
PNG
(2-(1-benzyl-1H-indol-5-yloxy)-pyrido[3,4- d]pyrimi...)
Show SMILES Oc1nc(Oc2ccc3n(Cc4ccccc4)ccc3c2)nc2cnccc12
Show InChI InChI=1S/C22H16N4O2/c27-21-18-8-10-23-13-19(18)24-22(25-21)28-17-6-7-20-16(12-17)9-11-26(20)14-15-4-2-1-3-5-15/h1-13H,14H2,(H,24,25,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296078
PNG
(2-[4-(benzyl-methyl-amino)-phenoxy]- pyrido[3,4-d]...)
Show SMILES CN(Cc1ccccc1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C21H18N4O2/c1-25(14-15-5-3-2-4-6-15)16-7-9-17(10-8-16)27-21-23-19-13-22-12-11-18(19)20(26)24-21/h2-13H,14H2,1H3,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296103
PNG
(3-(4-{[4-(4-hydroxy-pyrido[3,4- d]pyrimidin-2-ylox...)
Show SMILES CC(CC#N)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C24H21N5O2/c1-16(11-13-25)17-3-5-18(6-4-17)29(2)19-7-9-20(10-8-19)31-24-27-22-15-26-14-12-21(22)23(30)28-24/h3-10,12,14-16H,11H2,1-2H3,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296113
PNG
(3-{[4-(4-hydroxy-pyrido[3,4-d]pyrimidin-2- yloxy)-...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)C#N
Show InChI InChI=1S/C21H15N5O2/c1-26(16-4-2-3-14(11-16)12-22)15-5-7-17(8-6-15)28-21-24-19-13-23-10-9-18(19)20(27)25-21/h2-11,13H,1H3,(H,24,25,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296115
PNG
(2-{4-[(4-cyclopropyl-phenyl)-methyl- amino]-phenox...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)C1CC1
Show InChI InChI=1S/C23H20N4O2/c1-27(17-6-4-16(5-7-17)15-2-3-15)18-8-10-19(11-9-18)29-23-25-21-14-24-13-12-20(21)22(28)26-23/h4-15H,2-3H2,1H3,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296128
PNG
(2-[4-[methyl-[(1R)-1- phenylethyl]amino]phenoxy]py...)
Show SMILES C[C@@H](N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccccc1
Show InChI InChI=1S/C22H20N4O2/c1-15(16-6-4-3-5-7-16)26(2)17-8-10-18(11-9-17)28-22-24-20-14-23-13-12-19(20)21(27)25-22/h3-15H,1-2H3,(H,24,25,27)/t15-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296173
PNG
(2-[4-(3-fluoro-N- methylanilino)phenoxy]pyrido[3,4...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccccc1F
Show InChI InChI=1S/C20H15FN4O2/c1-25(18-5-3-2-4-16(18)21)13-6-8-14(9-7-13)27-20-23-17-12-22-11-10-15(17)19(26)24-20/h2-12H,1H3,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296094
PNG
(2-[4-(methyl-m-tolyl-amino)-phenoxy]- pyrido[3,4-d...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(C)c1
Show InChI InChI=1S/C21H18N4O2/c1-14-4-3-5-16(12-14)25(2)15-6-8-17(9-7-15)27-21-23-19-13-22-11-10-18(19)20(26)24-21/h3-13H,1-2H3,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296118
PNG
(2-[4-[methyl-(5-methylpyridin-2- yl)amino]phenoxy]...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(C)cn1
Show InChI InChI=1S/C20H17N5O2/c1-13-3-8-18(22-11-13)25(2)14-4-6-15(7-5-14)27-20-23-17-12-21-10-9-16(17)19(26)24-20/h3-12H,1-2H3,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296120
PNG
(4-[3-[4-(4-hydroxypyrido[3,4-d]pyrimidin- 2-yl)oxy...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)N1CCN(C)C(=O)C1
Show InChI InChI=1S/C25H24N6O3/c1-29-12-13-31(16-23(29)32)19-5-3-4-18(14-19)30(2)17-6-8-20(9-7-17)34-25-27-22-15-26-11-10-21(22)24(33)28-25/h3-11,14-15H,12-13,16H2,1-2H3,(H,27,28,33)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296121
PNG
(2-[4-[N-methyl-4-(4-methylpiperazin-1- yl)anilino]...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C25H26N6O2/c1-29-13-15-31(16-14-29)20-5-3-18(4-6-20)30(2)19-7-9-21(10-8-19)33-25-27-23-17-26-12-11-22(23)24(32)28-25/h3-12,17H,13-16H2,1-2H3,(H,27,28,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296161
PNG
(2-[4-(4-ethyl-N- methylanilino)phenoxy]pyrido[3,4-...)
Show SMILES CCc1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C22H20N4O2/c1-3-15-4-6-16(7-5-15)26(2)17-8-10-18(11-9-17)28-22-24-20-14-23-13-12-19(20)21(27)25-22/h4-14H,3H2,1-2H3,(H,24,25,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296170
PNG
(2-[4-(N-methyl-3-propan-2- ylanilino)phenoxy]pyrid...)
Show SMILES CC(C)c1cccc(c1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C23H22N4O2/c1-15(2)16-5-4-6-18(13-16)27(3)17-7-9-19(10-8-17)29-23-25-21-14-24-12-11-20(21)22(28)26-23/h4-15H,1-3H3,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296179
PNG
(2-[4-[N-(2-methoxyethyl)-4-propan-2- ylanilino]phe...)
Show SMILES COCCN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C25H26N4O3/c1-17(2)18-4-6-19(7-5-18)29(14-15-31-3)20-8-10-21(11-9-20)32-25-27-23-16-26-13-12-22(23)24(30)28-25/h4-13,16-17H,14-15H2,1-3H3,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296086
PNG
(2-[2-benzyl-2H-indazol-5- yloxy]pyridino[3,4-d]pyr...)
Show SMILES Oc1nc(Oc2ccc3nn(Cc4ccccc4)cc3c2)nc2cnccc12
Show InChI InChI=1S/C21H15N5O2/c27-20-17-8-9-22-11-19(17)23-21(24-20)28-16-6-7-18-15(10-16)13-26(25-18)12-14-4-2-1-3-5-14/h1-11,13H,12H2,(H,23,24,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296088
PNG
(2-{4-[(4-methoxy-phenyl)-methyl-amino]- phenoxy}-p...)
Show SMILES COc1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C21H18N4O3/c1-25(14-3-7-16(27-2)8-4-14)15-5-9-17(10-6-15)28-21-23-19-13-22-12-11-18(19)20(26)24-21/h3-13H,1-2H3,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296092
PNG
(2-{4-[methyl-(3-morpholin-4-yl-phenyl)- amino]-phe...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C24H23N5O3/c1-28(18-3-2-4-19(15-18)29-11-13-31-14-12-29)17-5-7-20(8-6-17)32-24-26-22-16-25-10-9-21(22)23(30)27-24/h2-10,15-16H,11-14H2,1H3,(H,26,27,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296093
PNG
(2-[4-(methyl-p-tolyl-amino)-phenoxy]- pyrido[3,4-d...)
Show SMILES CN(c1ccc(C)cc1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C21H18N4O2/c1-14-3-5-15(6-4-14)25(2)16-7-9-17(10-8-16)27-21-23-19-13-22-12-11-18(19)20(26)24-21/h3-13H,1-2H3,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296098
PNG
(2-[4-(3-phenyl-piperidin-1-yl)-phenoxy]- pyrido[3,...)
Show SMILES Oc1nc(Oc2ccc(cc2)N2CCCC(C2)c2ccccc2)nc2cnccc12
Show InChI InChI=1S/C24H22N4O2/c29-23-21-12-13-25-15-22(21)26-24(27-23)30-20-10-8-19(9-11-20)28-14-4-7-18(16-28)17-5-2-1-3-6-17/h1-3,5-6,8-13,15,18H,4,7,14,16H2,(H,26,27,29)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296111
PNG
(2-{4-[(4-{2-[(2-methoxy-ethyl)-methyl- amino]-1-me...)
Show SMILES COCCN(C)CC(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C27H31N5O3/c1-19(18-31(2)15-16-34-4)20-5-7-21(8-6-20)32(3)22-9-11-23(12-10-22)35-27-29-25-17-28-14-13-24(25)26(33)30-27/h5-14,17,19H,15-16,18H2,1-4H3,(H,29,30,33)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296129
PNG
(2-[4-(3-fluoro-N,4- dimethylanilino)phenoxy]pyrido...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(C)c(F)c1
Show InChI InChI=1S/C21H17FN4O2/c1-13-3-4-15(11-18(13)22)26(2)14-5-7-16(8-6-14)28-21-24-19-12-23-10-9-17(19)20(27)25-21/h3-12H,1-2H3,(H,24,25,27)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296144
PNG
(2-[4-[4-(1-hydroxy-2-methylpropan-2-yl)- N-methyla...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)C(C)(C)CO
Show InChI InChI=1S/C24H24N4O3/c1-24(2,15-29)16-4-6-17(7-5-16)28(3)18-8-10-19(11-9-18)31-23-26-21-14-25-13-12-20(21)22(30)27-23/h4-14,29H,15H2,1-3H3,(H,26,27,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296156
PNG
(2-[4-(N-ethylanilino)phenoxy]pyrido[3,4- d]pyrimid...)
Show SMILES CCN(c1ccccc1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C21H18N4O2/c1-2-25(15-6-4-3-5-7-15)16-8-10-17(11-9-16)27-21-23-19-14-22-13-12-18(19)20(26)24-21/h3-14H,2H2,1H3,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296171
PNG
(2-[4-(4-chloro-N- methylanilino)phenoxy]pyrido[3,4...)
Show SMILES CN(c1ccc(Cl)cc1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C20H15ClN4O2/c1-25(14-4-2-13(21)3-5-14)15-6-8-16(9-7-15)27-20-23-18-12-22-11-10-17(18)19(26)24-20/h2-12H,1H3,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296188
PNG
(2-[4-(N-methyl-4-propan-2- yloxyanilino)phenoxy]py...)
Show SMILES CC(C)Oc1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C23H22N4O3/c1-15(2)29-18-8-4-16(5-9-18)27(3)17-6-10-19(11-7-17)30-23-25-21-14-24-13-12-20(21)22(28)26-23/h4-15H,1-3H3,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296191
PNG
((3,3-dimethyl-2,3-dihydro-benzofuran-6- yl)-methyl...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc2c(OCC2(C)C)c1
Show InChI InChI=1S/C24H22N4O3/c1-24(2)14-30-21-12-16(6-9-19(21)24)28(3)15-4-7-17(8-5-15)31-23-26-20-13-25-11-10-18(20)22(29)27-23/h4-13H,14H2,1-3H3,(H,26,27,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM350221
PNG
(2-(4-((4-ethyl-3-methoxyphenyl) (methyl)amino)phen...)
Show SMILES CCc1ccc(cc1OC)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C23H22N4O3/c1-4-15-5-6-17(13-21(15)29-3)27(2)16-7-9-18(10-8-16)30-23-25-20-14-24-12-11-19(20)22(28)26-23/h5-14H,4H2,1-3H3,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM350223
PNG
(2-(4-((4-ethyl-2-methoxyphenyl) (methyl)amino)phen...)
Show SMILES CCc1ccc(N(C)c2ccc(Oc3nc(O)c4ccncc4n3)cc2)c(OC)c1
Show InChI InChI=1S/C23H22N4O3/c1-4-15-5-10-20(21(13-15)29-3)27(2)16-6-8-17(9-7-16)30-23-25-19-14-24-12-11-18(19)22(28)26-23/h5-14H,4H2,1-3H3,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347142
PNG
(2-(3-methyl-4-(methyl(4- propylphenyl)amino)phenox...)
Show SMILES CCCc1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1C
Show InChI InChI=1S/C24H24N4O2/c1-4-5-17-6-8-18(9-7-17)28(3)22-11-10-19(14-16(22)2)30-24-26-21-15-25-13-12-20(21)23(29)27-24/h6-15H,4-5H2,1-3H3,(H,26,27,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296077
PNG
(2-[4-(methyl-phenyl-amino)-phenoxy]- pyrido[3,4-d]...)
Show SMILES CN(c1ccccc1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C20H16N4O2/c1-24(14-5-3-2-4-6-14)15-7-9-16(10-8-15)26-20-22-18-13-21-12-11-17(18)19(25)23-20/h2-13H,1H3,(H,22,23,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296102
PNG
(2-(4-{[4-(2-methoxy-1-methyl-ethyl)- phenyl]-methy...)
Show SMILES COCC(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C24H24N4O3/c1-16(15-30-3)17-4-6-18(7-5-17)28(2)19-8-10-20(11-9-19)31-24-26-22-14-25-13-12-21(22)23(29)27-24/h4-14,16H,15H2,1-3H3,(H,26,27,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296105
PNG
(2-(1-phenyl-2,3-dihydro-1H-indol-5-yloxy)- pyrido[...)
Show SMILES Oc1nc(Oc2ccc3N(CCc3c2)c2ccccc2)nc2cnccc12
Show InChI InChI=1S/C21H16N4O2/c26-20-17-8-10-22-13-18(17)23-21(24-20)27-16-6-7-19-14(12-16)9-11-25(19)15-4-2-1-3-5-15/h1-8,10,12-13H,9,11H2,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296109
PNG
(2-(4-{[4-(1-methoxy-ethyl)-phenyl]-methyl- amino}-...)
Show SMILES COC(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C23H22N4O3/c1-15(29-3)16-4-6-17(7-5-16)27(2)18-8-10-19(11-9-18)30-23-25-21-14-24-13-12-20(21)22(28)26-23/h4-15H,1-3H3,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296139
PNG
(2-[4-[N-methyl-4-(2- methylpropyl)anilino]phenoxy]...)
Show SMILES CC(C)Cc1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C24H24N4O2/c1-16(2)14-17-4-6-18(7-5-17)28(3)19-8-10-20(11-9-19)30-24-26-22-15-25-13-12-21(22)23(29)27-24/h4-13,15-16H,14H2,1-3H3,(H,26,27,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296157
PNG
(4-[4-(4-hydroxypyrido[3,4-d]pyrimidin-2- yl)oxy-N-...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C21H15N5O2/c1-26(15-4-2-14(12-22)3-5-15)16-6-8-17(9-7-16)28-21-24-19-13-23-11-10-18(19)20(27)25-21/h2-11,13H,1H3,(H,24,25,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296158
PNG
(2-[4-[methyl-(2-methylindazol-5- yl)amino]phenoxy]...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc2nn(C)cc2c1
Show InChI InChI=1S/C22H18N6O2/c1-27-13-14-11-16(5-8-19(14)26-27)28(2)15-3-6-17(7-4-15)30-22-24-20-12-23-10-9-18(20)21(29)25-22/h3-13H,1-2H3,(H,24,25,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296186
PNG
(2-[4-[methyl-(6-propan-2-ylpyridin-3- yl)amino]phe...)
Show SMILES CC(C)c1ccc(cn1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C22H21N5O2/c1-14(2)19-9-6-16(12-24-19)27(3)15-4-7-17(8-5-15)29-22-25-20-13-23-11-10-18(20)21(28)26-22/h4-14H,1-3H3,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347113
PNG
(2-(4-((4-isopropylphenyl)(propyl)amino) phenoxy)py...)
Show SMILES CCCN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C25H26N4O2/c1-4-15-29(19-7-5-18(6-8-19)17(2)3)20-9-11-21(12-10-20)31-25-27-23-16-26-14-13-22(23)24(30)28-25/h5-14,16-17H,4,15H2,1-3H3,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347141
PNG
(2-(4-((4-(tert-butyl)phenyl)(methyl) amino)-3-meth...)
Show SMILES CN(c1ccc(cc1)C(C)(C)C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1C
Show InChI InChI=1S/C25H26N4O2/c1-16-14-19(31-24-27-21-15-26-13-12-20(21)23(30)28-24)10-11-22(16)29(5)18-8-6-17(7-9-18)25(2,3)4/h6-15H,1-5H3,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296082
PNG
(2-[3-fluoro-4-(methyl-phenyl-amino)- phenoxy]-pyri...)
Show SMILES CN(c1ccccc1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1F
Show InChI InChI=1S/C20H15FN4O2/c1-25(13-5-3-2-4-6-13)18-8-7-14(11-16(18)21)27-20-23-17-12-22-10-9-15(17)19(26)24-20/h2-12H,1H3,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296099
PNG
(2-[4-(2-phenyl-morpholin-4-yl)-phenoxy]- pyrido[3,...)
Show SMILES Oc1nc(Oc2ccc(cc2)N2CCOC(C2)c2ccccc2)nc2cnccc12
Show InChI InChI=1S/C23H20N4O3/c28-22-19-10-11-24-14-20(19)25-23(26-22)30-18-8-6-17(7-9-18)27-12-13-29-21(15-27)16-4-2-1-3-5-16/h1-11,14,21H,12-13,15H2,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296108
PNG
(2-{4-[(4-isopropyl-3-morpholin-4-yl- phenyl)-methy...)
Show SMILES CC(C)c1ccc(cc1N1CCOCC1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C27H29N5O3/c1-18(2)22-9-6-20(16-25(22)32-12-14-34-15-13-32)31(3)19-4-7-21(8-5-19)35-27-29-24-17-28-11-10-23(24)26(33)30-27/h4-11,16-18H,12-15H2,1-3H3,(H,29,30,33)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296189
PNG
(2-{4-[(4-isopropyl-phenyl)-(2,2,2-trifluoro- ethyl...)
Show SMILES CC(C)c1ccc(cc1)N(CC(F)(F)F)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C24H21F3N4O2/c1-15(2)16-3-5-17(6-4-16)31(14-24(25,26)27)18-7-9-19(10-8-18)33-23-29-21-13-28-12-11-20(21)22(32)30-23/h3-13,15H,14H2,1-2H3,(H,29,30,32)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296193
PNG
(2-(4-((4-isopropylphenyl)(tetrahydro-2H-pyran-4-yl...)
Show SMILES CC(C)c1ccc(cc1)N(C1CCOCC1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C27H28N4O3/c1-18(2)19-3-5-20(6-4-19)31(22-12-15-33-16-13-22)21-7-9-23(10-8-21)34-27-29-25-17-28-14-11-24(25)26(32)30-27/h3-11,14,17-18,22H,12-13,15-16H2,1-2H3,(H,29,30,32)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347124
PNG
(2-(4-((4-isopropylphenyl)(methyl)amino)-3- methylp...)
Show SMILES CC(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1C
Show InChI InChI=1S/C24H24N4O2/c1-15(2)17-5-7-18(8-6-17)28(4)22-10-9-19(13-16(22)3)30-24-26-21-14-25-12-11-20(21)23(29)27-24/h5-15H,1-4H3,(H,26,27,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296074
PNG
(2-(1-methyl-1H-indol-5-yloxy)-pyrido[3,4- d]pyrimi...)
Show SMILES Cn1ccc2cc(Oc3nc(O)c4ccncc4n3)ccc12
Show InChI InChI=1S/C16H12N4O2/c1-20-7-5-10-8-11(2-3-14(10)20)22-16-18-13-9-17-6-4-12(13)15(21)19-16/h2-9H,1H3,(H,18,19,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296083
PNG
(2-(1-benzyl-1H-indazol-6-yloxy)- pyrido[3,4-d]pyri...)
Show SMILES Oc1nc(Oc2ccc3cnn(Cc4ccccc4)c3c2)nc2cnccc12
Show InChI InChI=1S/C21H15N5O2/c27-20-17-8-9-22-12-18(17)24-21(25-20)28-16-7-6-15-11-23-26(19(15)10-16)13-14-4-2-1-3-5-14/h1-12H,13H2,(H,24,25,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296153
PNG
(2-[4-[4-[(2S)-butan-2-yl]-N- methylanilino]phenoxy...)
Show SMILES CC[C@H](C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C24H24N4O2/c1-4-16(2)17-5-7-18(8-6-17)28(3)19-9-11-20(12-10-19)30-24-26-22-15-25-14-13-21(22)23(29)27-24/h5-16H,4H2,1-3H3,(H,26,27,29)/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347115
PNG
(2-(4-isopropyl(4-isopropylphenyl)amino) phenoxy)py...)
Show SMILES CC(C)N(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C25H26N4O2/c1-16(2)18-5-7-19(8-6-18)29(17(3)4)20-9-11-21(12-10-20)31-25-27-23-15-26-14-13-22(23)24(30)28-25/h5-17H,1-4H3,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296080
PNG
(2-(1-benzyl-1H-indol-6-yloxy)-pyrido[3,4- d]pyrimi...)
Show SMILES Oc1nc(Oc2ccc3ccn(Cc4ccccc4)c3c2)nc2cnccc12
Show InChI InChI=1S/C22H16N4O2/c27-21-18-8-10-23-13-19(18)24-22(25-21)28-17-7-6-16-9-11-26(20(16)12-17)14-15-4-2-1-3-5-15/h1-13H,14H2,(H,24,25,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296106
PNG
(2-(1-phenyl-1,2,3,4-tetrahydro-quinolin-6- yloxy)-...)
Show SMILES Oc1nc(Oc2ccc3N(CCCc3c2)c2ccccc2)nc2cnccc12
Show InChI InChI=1S/C22H18N4O2/c27-21-18-10-11-23-14-19(18)24-22(25-21)28-17-8-9-20-15(13-17)5-4-12-26(20)16-6-2-1-3-7-16/h1-3,6-11,13-14H,4-5,12H2,(H,24,25,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296151
PNG
(2-[4-[4-(2,2-dimethylpropoxy)-N- methylanilino]phe...)
Show SMILES CN(c1ccc(OCC(C)(C)C)cc1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C25H26N4O3/c1-25(2,3)16-31-19-9-5-17(6-10-19)29(4)18-7-11-20(12-8-18)32-24-27-22-15-26-14-13-21(22)23(30)28-24/h5-15H,16H2,1-4H3,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296160
PNG
(2-[4-(N,3,4- trimethylanilino)phenoxy]pyrido[3,4- ...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(C)c(C)c1
Show InChI InChI=1S/C22H20N4O2/c1-14-4-5-17(12-15(14)2)26(3)16-6-8-18(9-7-16)28-22-24-20-13-23-11-10-19(20)21(27)25-22/h4-13H,1-3H3,(H,24,25,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296178
PNG
(2-[4-[4-(cyclopropylmethoxy)-N- methylanilino]phen...)
Show SMILES CN(c1ccc(OCC2CC2)cc1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C24H22N4O3/c1-28(17-4-8-19(9-5-17)30-15-16-2-3-16)18-6-10-20(11-7-18)31-24-26-22-14-25-13-12-21(22)23(29)27-24/h4-14,16H,2-3,15H2,1H3,(H,26,27,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296183
PNG
(2-[4-[N-methyl-4-(2,2,2- trifluoroethyl)anilino]ph...)
Show SMILES CN(c1ccc(CC(F)(F)F)cc1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C22H17F3N4O2/c1-29(15-4-2-14(3-5-15)12-22(23,24)25)16-6-8-17(9-7-16)31-21-27-19-13-26-11-10-18(19)20(30)28-21/h2-11,13H,12H2,1H3,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347118
PNG
(2-(4-(cyclopentyl(4-isopropylphenyl)amino) phenoxy...)
Show SMILES CC(C)c1ccc(cc1)N(C1CCCC1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C27H28N4O2/c1-18(2)19-7-9-21(10-8-19)31(20-5-3-4-6-20)22-11-13-23(14-12-22)33-27-29-25-17-28-16-15-24(25)26(32)30-27/h7-18,20H,3-6H2,1-2H3,(H,29,30,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296145
PNG
(2-[4-(N-methyl-4- propylanilino)phenoxy]pyrido[3,4...)
Show SMILES CCCc1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C23H22N4O2/c1-3-4-16-5-7-17(8-6-16)27(2)18-9-11-19(12-10-18)29-23-25-21-15-24-14-13-20(21)22(28)26-23/h5-15H,3-4H2,1-2H3,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296172
PNG
(2-[4-(3-chloro-N- methylanilino)phenoxy]pyrido[3,4...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C20H15ClN4O2/c1-25(15-4-2-3-13(21)11-15)14-5-7-16(8-6-14)27-20-23-18-12-22-10-9-17(18)19(26)24-20/h2-12H,1H3,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296180
PNG
(2-(1-phenylindol-5-yl)oxypyrido[3,4- d]pyrimidin-4...)
Show SMILES Oc1nc(Oc2ccc3n(ccc3c2)-c2ccccc2)nc2cnccc12
Show InChI InChI=1S/C21H14N4O2/c26-20-17-8-10-22-13-18(17)23-21(24-20)27-16-6-7-19-14(12-16)9-11-25(19)15-4-2-1-3-5-15/h1-13H,(H,23,24,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347136
PNG
(2-(4-((4-isopropylphenyl)(methyl) amino)-3-(triflu...)
Show SMILES CC(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1C(F)(F)F
Show InChI InChI=1S/C24H21F3N4O2/c1-14(2)15-4-6-16(7-5-15)31(3)21-9-8-17(12-19(21)24(25,26)27)33-23-29-20-13-28-11-10-18(20)22(32)30-23/h4-14H,1-3H3,(H,29,30,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296124
PNG
(2-[4-(N-methyl-4-pyrrolidin-1- ylanilino)phenoxy]p...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)N1CCCC1
Show InChI InChI=1S/C24H23N5O2/c1-28(17-4-6-19(7-5-17)29-14-2-3-15-29)18-8-10-20(11-9-18)31-24-26-22-16-25-13-12-21(22)23(30)27-24/h4-13,16H,2-3,14-15H2,1H3,(H,26,27,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296142
PNG
(2-[4-[4-ethyl-3-(2-methoxyethoxy)-N- methylanilino...)
Show SMILES CCc1ccc(cc1OCCOC)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C25H26N4O4/c1-4-17-5-6-19(15-23(17)32-14-13-31-3)29(2)18-7-9-20(10-8-18)33-25-27-22-16-26-12-11-21(22)24(30)28-25/h5-12,15-16H,4,13-14H2,1-3H3,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296150
PNG
(2-[4-[N-methyl-4-(2- methylpropoxy)anilino]phenoxy...)
Show SMILES CC(C)COc1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C24H24N4O3/c1-16(2)15-30-19-8-4-17(5-9-19)28(3)18-6-10-20(11-7-18)31-24-26-22-14-25-13-12-21(22)23(29)27-24/h4-14,16H,15H2,1-3H3,(H,26,27,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296154
PNG
(2-[4-[4-[(2R)-butan-2-yl]-N- methylanilino]phenoxy...)
Show SMILES CC[C@@H](C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C24H24N4O2/c1-4-16(2)17-5-7-18(8-6-17)28(3)19-9-11-20(12-10-19)30-24-26-22-15-25-14-13-21(22)23(29)27-24/h5-16H,4H2,1-3H3,(H,26,27,29)/t16-/m1/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296175
PNG
(2-[4-[4-(3,6-dihydro-2H-pyran-4-yl)-N- methylanili...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)C1=CCOCC1
Show InChI InChI=1S/C25H22N4O3/c1-29(19-4-2-17(3-5-19)18-11-14-31-15-12-18)20-6-8-21(9-7-20)32-25-27-23-16-26-13-10-22(23)24(30)28-25/h2-11,13,16H,12,14-15H2,1H3,(H,27,28,30)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296079
PNG
(2-[3-(methyl-phenyl-amino)-phenoxy]- pyrido[3,4-d]...)
Show SMILES CN(c1ccccc1)c1cccc(Oc2nc(O)c3ccncc3n2)c1
Show InChI InChI=1S/C20H16N4O2/c1-24(14-6-3-2-4-7-14)15-8-5-9-16(12-15)26-20-22-18-13-21-11-10-17(18)19(25)23-20/h2-13H,1H3,(H,22,23,25)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296152
PNG
(2-[4-[4-(cyclopropylmethyl)-N- methylanilino]pheno...)
Show SMILES CN(c1ccc(CC2CC2)cc1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C24H22N4O2/c1-28(18-6-4-17(5-7-18)14-16-2-3-16)19-8-10-20(11-9-19)30-24-26-22-15-25-13-12-21(22)23(29)27-24/h4-13,15-16H,2-3,14H2,1H3,(H,26,27,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296184
PNG
(2-[4-[N-methyl-4-[1- (trifluoromethyl)cyclopropyl]...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)C1(CC1)C(F)(F)F
Show InChI InChI=1S/C24H19F3N4O2/c1-31(16-4-2-15(3-5-16)23(11-12-23)24(25,26)27)17-6-8-18(9-7-17)33-22-29-20-14-28-13-10-19(20)21(32)30-22/h2-10,13-14H,11-12H2,1H3,(H,29,30,32)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296187
PNG
(2-[4-[N-methyl-4- (trifluoromethoxy)anilino]phenox...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C21H15F3N4O3/c1-28(14-4-8-16(9-5-14)31-21(22,23)24)13-2-6-15(7-3-13)30-20-26-18-12-25-11-10-17(18)19(29)27-20/h2-12H,1H3,(H,26,27,29)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296192
PNG
(2-(4-(ethyl(4- isopropylphenyl)amino)phenoxy)pyrid...)
Show SMILES CCN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C24H24N4O2/c1-4-28(18-7-5-17(6-8-18)16(2)3)19-9-11-20(12-10-19)30-24-26-22-15-25-14-13-21(22)23(29)27-24/h5-16H,4H2,1-3H3,(H,26,27,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296143
PNG
(2-[4-[4-(1-methoxy-2-methylpropan-2-yl)- N-methyla...)
Show SMILES COCC(C)(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C25H26N4O3/c1-25(2,16-31-4)17-5-7-18(8-6-17)29(3)19-9-11-20(12-10-19)32-24-27-22-15-26-14-13-21(22)23(30)28-24/h5-15H,16H2,1-4H3,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296162
PNG
(2-[4-(N-methyl-4-propan-2- ylanilino)phenoxy]pyrid...)
Show SMILES CC(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C23H22N4O2/c1-15(2)16-4-6-17(7-5-16)27(3)18-8-10-19(11-9-18)29-23-25-21-14-24-13-12-20(21)22(28)26-23/h4-15H,1-3H3,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296163
PNG
(2-[4-[N-methyl-3- (trifluoromethyl)anilino]phenoxy...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H15F3N4O2/c1-28(15-4-2-3-13(11-15)21(22,23)24)14-5-7-16(8-6-14)30-20-26-18-12-25-10-9-17(18)19(29)27-20/h2-12H,1H3,(H,26,27,29)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347116
PNG
(2-(4-(isobutyl(4-isopropylphenyl)amino) phenoxy)py...)
Show SMILES CC(C)CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C26H28N4O2/c1-17(2)16-30(20-7-5-19(6-8-20)18(3)4)21-9-11-22(12-10-21)32-26-28-24-15-27-14-13-23(24)25(31)29-26/h5-15,17-18H,16H2,1-4H3,(H,28,29,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296081
PNG
(2-[3-(benzyl-methyl-amino)-phenoxy]- pyrido[3,4-d]...)
Show SMILES CN(Cc1ccccc1)c1cccc(Oc2nc(O)c3ccncc3n2)c1
Show InChI InChI=1S/C21H18N4O2/c1-25(14-15-6-3-2-4-7-15)16-8-5-9-17(12-16)27-21-23-19-13-22-11-10-18(19)20(26)24-21/h2-13H,14H2,1H3,(H,23,24,26)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296104
PNG
(2-(1-cyclopentyl-1H-indol-5-yloxy)- pyrido[3,4-d]p...)
Show SMILES Oc1nc(Oc2ccc3n(ccc3c2)C2CCCC2)nc2cnccc12
Show InChI InChI=1S/C20H18N4O2/c25-19-16-7-9-21-12-17(16)22-20(23-19)26-15-5-6-18-13(11-15)8-10-24(18)14-3-1-2-4-14/h5-12,14H,1-4H2,(H,22,23,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296112
PNG
(2-(4-{[4-(1-cyclopropyl-ethyl)-phenyl]- methyl-ami...)
Show SMILES CC(C1CC1)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
Show InChI InChI=1S/C25H24N4O2/c1-16(17-3-4-17)18-5-7-19(8-6-18)29(2)20-9-11-21(12-10-20)31-25-27-23-15-26-14-13-22(23)24(30)28-25/h5-17H,3-4H2,1-2H3,(H,27,28,30)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296130
PNG
(2-[4-(3-phenylpyrrolidin-1- yl)phenoxy]pyrido[3,4-...)
Show SMILES Oc1nc(Oc2ccc(cc2)N2CCC(C2)c2ccccc2)nc2cnccc12
Show InChI InChI=1S/C23H20N4O2/c28-22-20-10-12-24-14-21(20)25-23(26-22)29-19-8-6-18(7-9-19)27-13-11-17(15-27)16-4-2-1-3-5-16/h1-10,12,14,17H,11,13,15H2,(H,25,26,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM296164
PNG
(2-[4-[N-methyl-4- (trifluoromethyl)anilino]phenoxy...)
Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H15F3N4O2/c1-28(14-4-2-13(3-5-14)21(22,23)24)15-6-8-16(9-7-15)30-20-26-18-12-25-11-10-17(18)19(29)27-20/h2-12H,1H3,(H,26,27,29)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%