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Patent code US10208056

Compile Data Set for Download or QSAR

Found 240 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350268
PNG
(US10208056, Compound 96)
Show SMILES CCn1c(cc2[C@H](Oc3cnccc3-c12)C1CCOCC1)C(N)=O
Show InChI InChI=1S/C18H21N3O3/c1-2-21-14(18(19)22)9-13-16(21)12-3-6-20-10-15(12)24-17(13)11-4-7-23-8-5-11/h3,6,9-11,17H,2,4-5,7-8H2,1H3,(H2,19,22)/t17-/m1/s1
PDB

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UniProtKB/SwissProt

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 0n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350267
PNG
(US10208056, Compound 95)
Show SMILES CCn1c(cc2[C@@H](Oc3cnccc3-c12)C1CCOCC1)C(N)=O
Show InChI InChI=1S/C18H21N3O3/c1-2-21-14(18(19)22)9-13-16(21)12-3-6-20-10-15(12)24-17(13)11-4-7-23-8-5-11/h3,6,9-11,17H,2,4-5,7-8H2,1H3,(H2,19,22)/t17-/m0/s1
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 0n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350265
PNG
(US10208056, Compound 92)
Show SMILES NC(=O)c1cc2c(-c3ccncc3OC22CCOCC2)n1CCF
Show InChI InChI=1S/C17H18FN3O3/c18-4-6-21-13(16(19)22)9-12-15(21)11-1-5-20-10-14(11)24-17(12)2-7-23-8-3-17/h1,5,9-10H,2-4,6-8H2,(H2,19,22)
PDB

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n/an/a 0n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350270
PNG
(US10208056, Compound 105)
Show SMILES CCn1c(C(N)=O)c(Cl)c2c1-c1ccncc1OC21CCCCC1
Show InChI InChI=1S/C18H20ClN3O2/c1-2-22-15-11-6-9-21-10-12(11)24-18(7-4-3-5-8-18)13(15)14(19)16(22)17(20)23/h6,9-10H,2-5,7-8H2,1H3,(H2,20,23)
PDB

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n/an/a 0n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350239
PNG
(US10208056, Compound 66)
Show SMILES CCn1c(cc2c1-c1ccncc1OC21CCC1)C(N)=O
Show InChI InChI=1S/C16H17N3O2/c1-2-19-12(15(17)20)8-11-14(19)10-4-7-18-9-13(10)21-16(11)5-3-6-16/h4,7-9H,2-3,5-6H2,1H3,(H2,17,20)
PDB

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US Patent
n/an/a 0.191n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350249
PNG
(US10208056, Compound 76)
Show SMILES NC(=O)c1cc2c(-c3ccncc3OC22CCC2)n1CCF
Show InChI InChI=1S/C16H16FN3O2/c17-5-7-20-12(15(18)21)8-11-14(20)10-2-6-19-9-13(10)22-16(11)3-1-4-16/h2,6,8-9H,1,3-5,7H2,(H2,18,21)
PDB

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UniChem
US Patent
n/an/a 0.262n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350256
PNG
(US10208056, Compound 83)
Show SMILES Cn1c(cc2c1-c1ccncc1OC21CCCCC1)C(N)=O
Show InChI InChI=1S/C17H19N3O2/c1-20-13(16(18)21)9-12-15(20)11-5-8-19-10-14(11)22-17(12)6-3-2-4-7-17/h5,8-10H,2-4,6-7H2,1H3,(H2,18,21)
PDB

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UniChem
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n/an/a 0.278n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350253
PNG
(US10208056, Compound 80)
Show SMILES CCn1c(cc2c1-c1ccncc1OC21CCCCC1)C(N)=O
Show InChI InChI=1S/C18H21N3O2/c1-2-21-14(17(19)22)10-13-16(21)12-6-9-20-11-15(12)23-18(13)7-4-3-5-8-18/h6,9-11H,2-5,7-8H2,1H3,(H2,19,22)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 0.314n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350262
PNG
(US10208056, Compound 89)
Show SMILES CCn1c(cc2[C@@H](Oc3cnccc3-c12)C1CCCCC1)C(N)=O
Show InChI InChI=1S/C19H23N3O2/c1-2-22-15(19(20)23)10-14-17(22)13-8-9-21-11-16(13)24-18(14)12-6-4-3-5-7-12/h8-12,18H,2-7H2,1H3,(H2,20,23)/t18-/m0/s1
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.407n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350240
PNG
(US10208056, Compound 67)
Show SMILES Cn1c(cc2c1-c1ccncc1OC21CCC1)C(N)=O
Show InChI InChI=1S/C15H15N3O2/c1-18-11(14(16)19)7-10-13(18)9-3-6-17-8-12(9)20-15(10)4-2-5-15/h3,6-8H,2,4-5H2,1H3,(H2,16,19)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.466n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350259
PNG
(US10208056, Compound 86)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(N)=O)c(C3CC3)c12
Show InChI InChI=1S/C16H17N3O2/c1-16(2)12-11(8-3-4-8)14(15(17)20)19-13(12)9-5-6-18-7-10(9)21-16/h5-8,19H,3-4H2,1-2H3,(H2,17,20)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.480n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350253
PNG
(US10208056, Compound 80)
Show SMILES CCn1c(cc2c1-c1ccncc1OC21CCCCC1)C(N)=O
Show InChI InChI=1S/C18H21N3O2/c1-2-21-14(17(19)22)10-13-16(21)12-6-9-20-11-15(12)23-18(13)7-4-3-5-8-18/h6,9-11H,2-5,7-8H2,1H3,(H2,19,22)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 0.770n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350249
PNG
(US10208056, Compound 76)
Show SMILES NC(=O)c1cc2c(-c3ccncc3OC22CCC2)n1CCF
Show InChI InChI=1S/C16H16FN3O2/c17-5-7-20-12(15(18)21)8-11-14(20)10-2-6-19-9-13(10)22-16(11)3-1-4-16/h2,6,8-9H,1,3-5,7H2,(H2,18,21)
PDB

UniProtKB/SwissProt

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DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.827n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350211
PNG
(US10208056, Compound 43)
Show SMILES CCn1c(cc2c1-c1ccncc1OC2(C)C)C(N)=O
Show InChI InChI=1S/C15H17N3O2/c1-4-18-11(14(16)19)7-10-13(18)9-5-6-17-8-12(9)20-15(10,2)3/h5-8H,4H2,1-3H3,(H2,16,19)
PDB

UniProtKB/SwissProt

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PC cid
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UniChem
US Patent
n/an/a 1.09n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350252
PNG
(US10208056, Compound 79)
Show SMILES CCn1c(cc2c1-c1ccncc1OC21CCN(CC(F)(F)F)CC1)C(N)=O
Show InChI InChI=1S/C19H21F3N4O2/c1-2-26-14(17(23)27)9-13-16(26)12-3-6-24-10-15(12)28-18(13)4-7-25(8-5-18)11-19(20,21)22/h3,6,9-10H,2,4-5,7-8,11H2,1H3,(H2,23,27)
PDB

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UniProtKB/SwissProt

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UniChem
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n/an/a 1.11n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350263
PNG
(US10208056, Compound 90)
Show SMILES CCn1c(cc2[C@H](Oc3cnccc3-c12)C1CCCCC1)C(N)=O
Show InChI InChI=1S/C19H23N3O2/c1-2-22-15(19(20)23)10-14-17(22)13-8-9-21-11-16(13)24-18(14)12-6-4-3-5-7-12/h8-12,18H,2-7H2,1H3,(H2,20,23)/t18-/m1/s1
PDB

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n/an/a 1.36n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350257
PNG
(US10208056, Compound 84)
Show SMILES NC(=O)c1cc2c(-c3ccncc3OC22CCCCC2)n1CCF
Show InChI InChI=1S/C18H20FN3O2/c19-7-9-22-14(17(20)23)10-13-16(22)12-4-8-21-11-15(12)24-18(13)5-2-1-3-6-18/h4,8,10-11H,1-3,5-7,9H2,(H2,20,23)
PDB

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n/an/a 1.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350227
PNG
(US10208056, Compound 57)
Show SMILES NC(=O)c1cc2C(Oc3cnccc3-c2[nH]1)C1CCCCC1
Show InChI InChI=1S/C17H19N3O2/c18-17(21)13-8-12-15(20-13)11-6-7-19-9-14(11)22-16(12)10-4-2-1-3-5-10/h6-10,16,20H,1-5H2,(H2,18,21)
PDB

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UniProtKB/SwissProt

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n/an/a 1.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350202
PNG
(US10208056, Compound 34)
Show SMILES CC1(C)Oc2cncc(Cl)c2-c2[nH]c(cc12)C(N)=O
Show InChI InChI=1S/C13H12ClN3O2/c1-13(2)6-3-8(12(15)18)17-11(6)10-7(14)4-16-5-9(10)19-13/h3-5,17H,1-2H3,(H2,15,18)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350262
PNG
(US10208056, Compound 89)
Show SMILES CCn1c(cc2[C@@H](Oc3cnccc3-c12)C1CCCCC1)C(N)=O
Show InChI InChI=1S/C19H23N3O2/c1-2-22-15(19(20)23)10-14-17(22)13-8-9-21-11-16(13)24-18(14)12-6-4-3-5-7-12/h8-12,18H,2-7H2,1H3,(H2,20,23)/t18-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350240
PNG
(US10208056, Compound 67)
Show SMILES Cn1c(cc2c1-c1ccncc1OC21CCC1)C(N)=O
Show InChI InChI=1S/C15H15N3O2/c1-18-11(14(16)19)7-10-13(18)9-3-6-17-8-12(9)20-15(10)4-2-5-15/h3,6-8H,2,4-5H2,1H3,(H2,16,19)
PDB

UniProtKB/SwissProt

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n/an/a 1.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350190
PNG
(US10208056, Compound 22)
Show SMILES Cn1c(cc2c1-c1ccncc1OC2(C)C)C(N)=O
Show InChI InChI=1S/C14H15N3O2/c1-14(2)9-6-10(13(15)18)17(3)12(9)8-4-5-16-7-11(8)19-14/h4-7H,1-3H3,(H2,15,18)
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n/an/a 1.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350220
PNG
(US10208056, Compound 52)
Show SMILES CC1(C)Oc2cnccc2-c2c1cc(C(N)=O)n2CCF
Show InChI InChI=1S/C15H16FN3O2/c1-15(2)10-7-11(14(17)20)19(6-4-16)13(10)9-3-5-18-8-12(9)21-15/h3,5,7-8H,4,6H2,1-2H3,(H2,17,20)
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n/an/a 1.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350263
PNG
(US10208056, Compound 90)
Show SMILES CCn1c(cc2[C@H](Oc3cnccc3-c12)C1CCCCC1)C(N)=O
Show InChI InChI=1S/C19H23N3O2/c1-2-22-15(19(20)23)10-14-17(22)13-8-9-21-11-16(13)24-18(14)12-6-4-3-5-7-12/h8-12,18H,2-7H2,1H3,(H2,20,23)/t18-/m1/s1
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n/an/a 1.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350220
PNG
(US10208056, Compound 52)
Show SMILES CC1(C)Oc2cnccc2-c2c1cc(C(N)=O)n2CCF
Show InChI InChI=1S/C15H16FN3O2/c1-15(2)10-7-11(14(17)20)19(6-4-16)13(10)9-3-5-18-8-12(9)21-15/h3,5,7-8H,4,6H2,1-2H3,(H2,17,20)
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n/an/a 1.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350239
PNG
(US10208056, Compound 66)
Show SMILES CCn1c(cc2c1-c1ccncc1OC21CCC1)C(N)=O
Show InChI InChI=1S/C16H17N3O2/c1-2-19-12(15(17)20)8-11-14(19)10-4-7-18-9-13(10)21-16(11)5-3-6-16/h4,7-9H,2-3,5-6H2,1H3,(H2,17,20)
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n/an/a 1.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350211
PNG
(US10208056, Compound 43)
Show SMILES CCn1c(cc2c1-c1ccncc1OC2(C)C)C(N)=O
Show InChI InChI=1S/C15H17N3O2/c1-4-18-11(14(16)19)7-10-13(18)9-5-6-17-8-12(9)20-15(10,2)3/h5-8H,4H2,1-3H3,(H2,16,19)
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n/an/a 1.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350183
PNG
(US10208056, Compound 15)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCC1
Show InChI InChI=1S/C14H13N3O2/c15-13(18)10-6-9-12(17-10)8-2-5-16-7-11(8)19-14(9)3-1-4-14/h2,5-7,17H,1,3-4H2,(H2,15,18)
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n/an/a 1.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350256
PNG
(US10208056, Compound 83)
Show SMILES Cn1c(cc2c1-c1ccncc1OC21CCCCC1)C(N)=O
Show InChI InChI=1S/C17H19N3O2/c1-20-13(16(18)21)9-12-15(20)11-5-8-19-10-14(11)22-17(12)6-3-2-4-7-17/h5,8-10H,2-4,6-7H2,1H3,(H2,18,21)
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n/an/a 1.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350183
PNG
(US10208056, Compound 15)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCC1
Show InChI InChI=1S/C14H13N3O2/c15-13(18)10-6-9-12(17-10)8-2-5-16-7-11(8)19-14(9)3-1-4-14/h2,5-7,17H,1,3-4H2,(H2,15,18)
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n/an/a 1.96n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350190
PNG
(US10208056, Compound 22)
Show SMILES Cn1c(cc2c1-c1ccncc1OC2(C)C)C(N)=O
Show InChI InChI=1S/C14H15N3O2/c1-14(2)9-6-10(13(15)18)17(3)12(9)8-4-5-16-7-11(8)19-14/h4-7H,1-3H3,(H2,15,18)
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n/an/a 1.98n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350202
PNG
(US10208056, Compound 34)
Show SMILES CC1(C)Oc2cncc(Cl)c2-c2[nH]c(cc12)C(N)=O
Show InChI InChI=1S/C13H12ClN3O2/c1-13(2)6-3-8(12(15)18)17-11(6)10-7(14)4-16-5-9(10)19-13/h3-5,17H,1-2H3,(H2,15,18)
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n/an/a 2.10n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350255
PNG
(US10208056, Compound 82)
Show SMILES CCn1c(cc2c1-c1ccncc1OC21CCOCC1)C(N)=O
Show InChI InChI=1S/C17H19N3O3/c1-2-20-13(16(18)21)9-12-15(20)11-3-6-19-10-14(11)23-17(12)4-7-22-8-5-17/h3,6,9-10H,2,4-5,7-8H2,1H3,(H2,18,21)
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n/an/a 2.19n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350269
PNG
(US10208056, Compound 104)
Show SMILES CCn1c(C(N)=O)c(Cl)c2c1-c1ccncc1OC21CCOCC1
Show InChI InChI=1S/C17H18ClN3O3/c1-2-21-14-10-3-6-20-9-11(10)24-17(4-7-23-8-5-17)12(14)13(18)15(21)16(19)22/h3,6,9H,2,4-5,7-8H2,1H3,(H2,19,22)
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n/an/a 2.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350169
PNG
(US10208056, Compound 1)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(cc12)C(N)=O
Show InChI InChI=1S/C13H13N3O2/c1-13(2)8-5-9(12(14)17)16-11(8)7-3-4-15-6-10(7)18-13/h3-6,16H,1-2H3,(H2,14,17)
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n/an/a 2.59n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350266
PNG
(US10208056, Compound 94)
Show SMILES CCn1c(C(N)=O)c(C2CC2)c2c1-c1ccncc1OC2(C)C
Show InChI InChI=1S/C18H21N3O2/c1-4-21-15-11-7-8-20-9-12(11)23-18(2,3)14(15)13(10-5-6-10)16(21)17(19)22/h7-10H,4-6H2,1-3H3,(H2,19,22)
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n/an/a 2.65n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350182
PNG
(US10208056, Compound 14)
Show SMILES OC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCCCC1
Show InChI InChI=1S/C16H16N2O3/c19-15(20)12-8-11-14(18-12)10-4-7-17-9-13(10)21-16(11)5-2-1-3-6-16/h4,7-9,18H,1-3,5-6H2,(H,19,20)
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n/an/a 3.01n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350252
PNG
(US10208056, Compound 79)
Show SMILES CCn1c(cc2c1-c1ccncc1OC21CCN(CC(F)(F)F)CC1)C(N)=O
Show InChI InChI=1S/C19H21F3N4O2/c1-2-26-14(17(23)27)9-13-16(26)12-3-6-24-10-15(12)28-18(13)4-7-25(8-5-18)11-19(20,21)22/h3,6,9-10H,2,4-5,7-8,11H2,1H3,(H2,23,27)
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n/an/a 3.14n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350241
PNG
(US10208056, Compound 68)
Show SMILES CCn1c(C(N)=O)c(c2c1-c1ccncc1OC2(C)C)-c1ccccc1OC
Show InChI InChI=1S/C22H23N3O3/c1-5-25-19-14-10-11-24-12-16(14)28-22(2,3)18(19)17(20(25)21(23)26)13-8-6-7-9-15(13)27-4/h6-12H,5H2,1-4H3,(H2,23,26)
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n/an/a 3.23n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350254
PNG
(US10208056, Compound 81)
Show SMILES Cn1c(cc2c1-c1ccncc1OC21CCOCC1)C(N)=O
Show InChI InChI=1S/C16H17N3O3/c1-19-12(15(17)20)8-11-14(19)10-2-5-18-9-13(10)22-16(11)3-6-21-7-4-16/h2,5,8-9H,3-4,6-7H2,1H3,(H2,17,20)
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n/an/a 3.83n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350181
PNG
(US10208056, Compound 13)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCCCC1
Show InChI InChI=1S/C16H17N3O2/c17-15(20)12-8-11-14(19-12)10-4-7-18-9-13(10)21-16(11)5-2-1-3-6-16/h4,7-9,19H,1-3,5-6H2,(H2,17,20)
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n/an/a 4.18n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350259
PNG
(US10208056, Compound 86)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(N)=O)c(C3CC3)c12
Show InChI InChI=1S/C16H17N3O2/c1-16(2)12-11(8-3-4-8)14(15(17)20)19-13(12)9-5-6-18-7-10(9)21-16/h5-8,19H,3-4H2,1-2H3,(H2,17,20)
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n/an/a 4.33n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350245
PNG
(US10208056, Compound 72)
Show SMILES NC(=O)c1cc2[C@@H](Oc3cnccc3-c2[nH]1)C1CCOCC1
Show InChI InChI=1S/C16H17N3O3/c17-16(20)12-7-11-14(19-12)10-1-4-18-8-13(10)22-15(11)9-2-5-21-6-3-9/h1,4,7-9,15,19H,2-3,5-6H2,(H2,17,20)/t15-/m0/s1
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US Patent
n/an/a 4.46n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350255
PNG
(US10208056, Compound 82)
Show SMILES CCn1c(cc2c1-c1ccncc1OC21CCOCC1)C(N)=O
Show InChI InChI=1S/C17H19N3O3/c1-2-20-13(16(18)21)9-12-15(20)11-3-6-19-10-14(11)23-17(12)4-7-22-8-5-17/h3,6,9-10H,2,4-5,7-8H2,1H3,(H2,18,21)
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n/an/a 4.58n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350213
PNG
(US10208056, Compound 45)
Show SMILES COCCn1c(cc2c1-c1ccncc1OC2(C)C)C(N)=O
Show InChI InChI=1S/C16H19N3O3/c1-16(2)11-8-12(15(17)20)19(6-7-21-3)14(11)10-4-5-18-9-13(10)22-16/h4-5,8-9H,6-7H2,1-3H3,(H2,17,20)
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n/an/a 4.64n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350254
PNG
(US10208056, Compound 81)
Show SMILES Cn1c(cc2c1-c1ccncc1OC21CCOCC1)C(N)=O
Show InChI InChI=1S/C16H17N3O3/c1-19-12(15(17)20)8-11-14(19)10-2-5-18-9-13(10)22-16(11)3-6-21-7-4-16/h2,5,8-9H,3-4,6-7H2,1H3,(H2,17,20)
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n/an/a 6.10n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350243
PNG
(US10208056, Compound 70)
Show SMILES NC(=O)c1cc2[C@@H](Oc3cnccc3-c2[nH]1)C1CCCCC1
Show InChI InChI=1S/C17H19N3O2/c18-17(21)13-8-12-15(20-13)11-6-7-19-9-14(11)22-16(12)10-4-2-1-3-5-10/h6-10,16,20H,1-5H2,(H2,18,21)/t16-/m0/s1
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n/an/a 7.14n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350250
PNG
(US10208056, Compound 77)
Show SMILES CC(=O)N1CCC2(CC1)Oc1cnccc1-c1[nH]c(cc21)C(N)=O
Show InChI InChI=1S/C17H18N4O3/c1-10(22)21-6-3-17(4-7-21)12-8-13(16(18)23)20-15(12)11-2-5-19-9-14(11)24-17/h2,5,8-9,20H,3-4,6-7H2,1H3,(H2,18,23)
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n/an/a 7.48n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350181
PNG
(US10208056, Compound 13)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCCCC1
Show InChI InChI=1S/C16H17N3O2/c17-15(20)12-8-11-14(19-12)10-4-7-18-9-13(10)21-16(11)5-2-1-3-6-16/h4,7-9,19H,1-3,5-6H2,(H2,17,20)
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n/an/a 8.22n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350243
PNG
(US10208056, Compound 70)
Show SMILES NC(=O)c1cc2[C@@H](Oc3cnccc3-c2[nH]1)C1CCCCC1
Show InChI InChI=1S/C17H19N3O2/c18-17(21)13-8-12-15(20-13)11-6-7-19-9-14(11)22-16(12)10-4-2-1-3-5-10/h6-10,16,20H,1-5H2,(H2,18,21)/t16-/m0/s1
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n/an/a 8.5n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%