BindingDB logo
myBDB logout

Patent code US10208060

Compile Data Set for Download or QSAR
Found 10 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 1


(Homo sapiens (Human))
BDBM350280
PNG
(2-(4-Hydroxy-2-oxo-1-(3'- (trifluoromethoxy)-[1,1'...)
Show SMILES OC(=O)CNC(=O)c1c(O)c2CSCc2n(-c2ccc(cc2)-c2cccc(OC(F)(F)F)c2)c1=O
Show InChI InChI=1S/C23H17F3N2O6S/c24-23(25,26)34-15-3-1-2-13(8-15)12-4-6-14(7-5-12)28-17-11-35-10-16(17)20(31)19(22(28)33)21(32)27-9-18(29)30/h1-8,31H,9-11H2,(H,27,32)(H,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
To each well of a 384-well plate, 1 μL of test compounds in DMSO (final concentration ranging from 0.3 nM to 10 uM) were added into 20 μl o...


US Patent US10208060 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM350271
PNG
(2-(1-(4-chlorophenyl)-4- hydroxy-2-oxo-1,2,5,7- te...)
Show SMILES OC(=O)CNC(=O)c1c(O)c2COCc2n(-c2ccc(Cl)cc2)c1=O
Show InChI InChI=1S/C16H13ClN2O6/c17-8-1-3-9(4-2-8)19-11-7-25-6-10(11)14(22)13(16(19)24)15(23)18-5-12(20)21/h1-4,22H,5-7H2,(H,18,23)(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
To each well of a 384-well plate, 1 μL of test compounds in DMSO (final concentration ranging from 0.3 nM to 10 uM) were added into 20 μl o...


US Patent US10208060 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM350273
PNG
(2-(4-hydroxy-2-oxo-1-phenyl- 1,2,5,7-tetrahydrofur...)
Show SMILES OC(=O)CNC(=O)c1c(O)c2COCc2n(-c2ccccc2)c1=O
Show InChI InChI=1S/C16H14N2O6/c19-12(20)6-17-15(22)13-14(21)10-7-24-8-11(10)18(16(13)23)9-4-2-1-3-5-9/h1-5,21H,6-8H2,(H,17,22)(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
To each well of a 384-well plate, 1 μL of test compounds in DMSO (final concentration ranging from 0.3 nM to 10 uM) were added into 20 μl o...


US Patent US10208060 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM350276
PNG
(2-(4-hydroxy-2-oxo-1-(m- tolyl)-1,2,5,7- tetrahydr...)
Show SMILES Cc1cccc(c1)-n1c2COCc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C17H16N2O6/c1-9-3-2-4-10(5-9)19-12-8-25-7-11(12)15(22)14(17(19)24)16(23)18-6-13(20)21/h2-5,22H,6-8H2,1H3,(H,18,23)(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
To each well of a 384-well plate, 1 μL of test compounds in DMSO (final concentration ranging from 0.3 nM to 10 uM) were added into 20 μl o...


US Patent US10208060 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM350278
PNG
(2-(1-(4-cyanophenyl)-4- hydroxy-2-oxo-1,2,5,7- tet...)
Show SMILES OC(=O)CNC(=O)c1c(O)c2COCc2n(-c2ccc(cc2)C#N)c1=O
Show InChI InChI=1S/C17H13N3O6/c18-5-9-1-3-10(4-2-9)20-12-8-26-7-11(12)15(23)14(17(20)25)16(24)19-6-13(21)22/h1-4,23H,6-8H2,(H,19,24)(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
To each well of a 384-well plate, 1 μL of test compounds in DMSO (final concentration ranging from 0.3 nM to 10 uM) were added into 20 μl o...


US Patent US10208060 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM350277
PNG
(2-(4-hydroxy-2-oxo-1-(p- tolyl)-1,2,5,7- tetrahydr...)
Show SMILES Cc1ccc(cc1)-n1c2COCc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C17H16N2O6/c1-9-2-4-10(5-3-9)19-12-8-25-7-11(12)15(22)14(17(19)24)16(23)18-6-13(20)21/h2-5,22H,6-8H2,1H3,(H,18,23)(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
To each well of a 384-well plate, 1 μL of test compounds in DMSO (final concentration ranging from 0.3 nM to 10 uM) were added into 20 μl o...


US Patent US10208060 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM350274
PNG
(2-(4-hydroxy-1-(4- methoxyphenyl)-2-oxo- 1,2,5,7-t...)
Show SMILES COc1ccc(cc1)-n1c2COCc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C17H16N2O7/c1-25-10-4-2-9(3-5-10)19-12-8-26-7-11(12)15(22)14(17(19)24)16(23)18-6-13(20)21/h2-5,22H,6-8H2,1H3,(H,18,23)(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11.4n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
To each well of a 384-well plate, 1 μL of test compounds in DMSO (final concentration ranging from 0.3 nM to 10 uM) were added into 20 μl o...


US Patent US10208060 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM350275
PNG
(2-(4-hydroxy-2-oxo-1-(4- (trifluoromethoxy)phenyl)...)
Show SMILES OC(=O)CNC(=O)c1c(O)c2COCc2n(-c2ccc(OC(F)(F)F)cc2)c1=O
Show InChI InChI=1S/C17H13F3N2O7/c18-17(19,20)29-9-3-1-8(2-4-9)22-11-7-28-6-10(11)14(25)13(16(22)27)15(26)21-5-12(23)24/h1-4,25H,5-7H2,(H,21,26)(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13.4n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
To each well of a 384-well plate, 1 μL of test compounds in DMSO (final concentration ranging from 0.3 nM to 10 uM) were added into 20 μl o...


US Patent US10208060 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM350272
PNG
(2-(1-(4-fluorophenyl)-4- hydroxy-2-oxo-1,2,5,7- te...)
Show SMILES OC(=O)CNC(=O)c1c(O)c2COCc2n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C16H13FN2O6/c17-8-1-3-9(4-2-8)19-11-7-25-6-10(11)14(22)13(16(19)24)15(23)18-5-12(20)21/h1-4,22H,5-7H2,(H,18,23)(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 14.1n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
To each well of a 384-well plate, 1 μL of test compounds in DMSO (final concentration ranging from 0.3 nM to 10 uM) were added into 20 μl o...


US Patent US10208060 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM350279
PNG
(2-(4-hydroxy-1-(5- methoxypyridin-2-yl)-2-oxo- 1,2...)
Show SMILES COc1ccc(nc1)-n1c2COCc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C16H15N3O7/c1-25-8-2-3-11(17-4-8)19-10-7-26-6-9(10)14(22)13(16(19)24)15(23)18-5-12(20)21/h2-4,22H,5-7H2,1H3,(H,18,23)(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 14.2n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
To each well of a 384-well plate, 1 μL of test compounds in DMSO (final concentration ranging from 0.3 nM to 10 uM) were added into 20 μl o...


US Patent US10208060 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%