BindingDB logo
myBDB logout

Patent code US10213427

Compile Data Set for Download or QSAR
Found 107 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356576
PNG
(N-[3-(7-{1-[2-(3,3-Difluoropyrrolidin-1-yl)-1-meth...)
Show SMILES CC(N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1)C(=O)N1CCC(F)(F)C1
Show InChI InChI=1S/C25H25F5N8O2/c1-15(22(39)37-6-5-24(26,27)14-37)32-10-18(9-31)17-8-21-33-12-20(38(21)35-11-17)16-3-2-4-19(7-16)36-23(40)34-13-25(28,29)30/h2-4,7-12,15,31-32H,5-6,13-14H2,1H3,(H2,34,36,40)/b18-10+,31-9?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356601
PNG
(N-[3-(7-{1-[1-(Cyanomethyl)-2,2,2-trifluoroethyl]-...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C(CC#N)C(F)(F)F
Show InChI InChI=1S/C22H16F6N8O/c23-21(24,25)12-31-20(37)34-16-3-1-2-13(6-16)17-10-30-19-7-14(8-33-36(17)19)15-9-32-35(11-15)18(4-5-29)22(26,27)28/h1-3,6-11,18H,4,12H2,(H2,31,34,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356611
PNG
(N-[(2S)-Tetrahydrofuran-2-ylmethyl]-2-(4-{3-[3-(({...)
Show SMILES CC(C(=O)NC[C@@H]1CCCO1)c1ccc(cc1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C29H29F3N6O3/c1-18(27(39)34-15-24-6-3-11-41-24)19-7-9-20(10-8-19)22-13-26-33-16-25(38(26)36-14-22)21-4-2-5-23(12-21)37-28(40)35-17-29(30,31)32/h2,4-5,7-10,12-14,16,18,24H,3,6,11,15,17H2,1H3,(H,34,39)(H2,35,37,40)/t18?,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356518
PNG
(N-(Cyclopropylmethyl)-4-{1-[3-({[(2,2,2-trifluoroe...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1ccc(cc1)C(=O)NCC1CC1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)15-32-26(37)34-21-2-1-3-22(13-21)35-16-33-23-12-20(10-11-24(23)35)18-6-8-19(9-7-18)25(36)31-14-17-4-5-17/h1-3,6-13,16-17H,4-5,14-15H2,(H,31,36)(H2,32,34,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356547
PNG
(N-[3-(7-{1-[1-(Pyrrolidin-1-ylcarbonyl)piperidin-4...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C1CCN(CC1)C(=O)N1CCCC1
Show InChI InChI=1S/C28H30F3N9O2/c29-28(30,31)18-33-26(41)36-22-5-3-4-19(12-22)24-16-32-25-13-20(14-35-40(24)25)21-15-34-39(17-21)23-6-10-38(11-7-23)27(42)37-8-1-2-9-37/h3-5,12-17,23H,1-2,6-11,18H2,(H2,33,36,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356554
PNG
(N-{3-[7-(1-{1-[(1-hydroxycyclopropyl)carbonyl]pipe...)
Show SMILES OC1(CC1)C(=O)N1CCC(CC1)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H27F3N8O3/c28-27(29,30)16-32-25(40)35-20-3-1-2-17(10-20)22-14-31-23-11-18(12-34-38(22)23)19-13-33-37(15-19)21-4-8-36(9-5-21)24(39)26(41)6-7-26/h1-3,10-15,21,41H,4-9,16H2,(H2,32,35,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356565
PNG
(N-Cyclopropyl-2-(4-{3-[3-({[(2,2,2-trifluoroethyl)...)
Show SMILES CC(N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1)C(=O)NC1CC1
Show InChI InChI=1S/C24H25F3N8O2/c1-14(22(36)33-18-5-6-18)29-10-17(9-28)16-8-21-30-12-20(35(21)32-11-16)15-3-2-4-19(7-15)34-23(37)31-13-24(25,26)27/h2-4,7-12,14,18,28-29H,5-6,13H2,1H3,(H,33,36)(H2,31,34,37)/b17-10+,28-9?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356570
PNG
(N-Methyl-N-(tetrahydro-2H-pyran-4-yl)-2-(4-{3-[3-(...)
Show SMILES CC(N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1)C(=O)N(C)C1CCOCC1
Show InChI InChI=1S/C27H31F3N8O3/c1-17(25(39)37(2)22-6-8-41-9-7-22)32-13-20(12-31)19-11-24-33-15-23(38(24)35-14-19)18-4-3-5-21(10-18)36-26(40)34-16-27(28,29)30/h3-5,10-15,17,22,31-32H,6-9,16H2,1-2H3,(H2,34,36,40)/b20-13+,31-12?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356571
PNG
(N-[3-(7-{1-[1-Methyl-2-(4-methylpiperazin-1-yl)-2-...)
Show SMILES CC(N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1)C(=O)N1CCN(C)CC1
Show InChI InChI=1S/C26H30F3N9O2/c1-17(24(39)37-8-6-36(2)7-9-37)31-13-20(12-30)19-11-23-32-15-22(38(23)34-14-19)18-4-3-5-21(10-18)35-25(40)33-16-26(27,28)29/h3-5,10-15,17,30-31H,6-9,16H2,1-2H3,(H2,33,35,40)/b20-13+,30-12?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356582
PNG
(N-(1-Methylpiperidin-4-yl)-2-(4-{3-[3-({[(2,2,2-tr...)
Show SMILES CC(C(=O)NC1CCN(C)CC1)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H30F3N9O2/c1-17(25(40)35-21-6-8-37(2)9-7-21)38-15-20(13-33-38)19-11-24-31-14-23(39(24)34-12-19)18-4-3-5-22(10-18)36-26(41)32-16-27(28,29)30/h3-5,10-15,17,21H,6-9,16H2,1-2H3,(H,35,40)(H2,32,36,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356585
PNG
(N-{3-[7-(1-{3-(Cyanomethyl)-1-[(5-methylisoxazol-4...)
Show SMILES Cc1oncc1S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H23F3N10O4S/c1-17-23(12-36-44-17)45(42,43)38-15-26(16-38,5-6-31)39-13-20(10-34-39)19-8-24-32-11-22(40(24)35-9-19)18-3-2-4-21(7-18)37-25(41)33-14-27(28,29)30/h2-4,7-13H,5,14-16H2,1H3,(H2,33,37,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356602
PNG
(N-[3-(7-{1-[2-Cyano-1-(2-furyl)ethyl]-1H-pyrazol-4...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C(CC#N)c1ccco1
Show InChI InChI=1S/C25H19F3N8O2/c26-25(27,28)15-31-24(37)34-19-4-1-3-16(9-19)21-13-30-23-10-17(11-33-36(21)23)18-12-32-35(14-18)20(6-7-29)22-5-2-8-38-22/h1-5,8-14,20H,6,15H2,(H2,31,34,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356609
PNG
(N-Methyl-2-(4-{3-[3-({[(2,2,2-trifluoroethyl)amino...)
Show SMILES CNC(=O)C(C)c1ccc(cc1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C25H23F3N6O2/c1-15(23(35)29-2)16-6-8-17(9-7-16)19-11-22-30-13-21(34(22)32-12-19)18-4-3-5-20(10-18)33-24(36)31-14-25(26,27)28/h3-13,15H,14H2,1-2H3,(H,29,35)(H2,31,33,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356612
PNG
(N-{3-[7-(4-{2-[(3S)-3-Hydroxypyrrolidin-1-yl]-1-me...)
Show SMILES CC(C(=O)N1CC[C@H](O)C1)c1ccc(cc1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C28H27F3N6O3/c1-17(26(39)36-10-9-23(38)15-36)18-5-7-19(8-6-18)21-12-25-32-14-24(37(25)34-13-21)20-3-2-4-22(11-20)35-27(40)33-16-28(29,30)31/h2-8,11-14,17,23,38H,9-10,15-16H2,1H3,(H2,33,35,40)/t17?,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356614
PNG
(N-[(3R)-Tetrahydrofuran-3-yl]-2-(4-{3-[3-({[(2,2,2...)
Show SMILES CC(C(=O)N[C@@H]1CCOC1)c1ccc(cc1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C28H27F3N6O3/c1-17(26(38)35-23-9-10-40-15-23)18-5-7-19(8-6-18)21-12-25-32-14-24(37(25)34-13-21)20-3-2-4-22(11-20)36-27(39)33-16-28(29,30)31/h2-8,11-14,17,23H,9-10,15-16H2,1H3,(H,35,38)(H2,33,36,39)/t17?,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356514
PNG
(N-[(1-Methylpiperidin-4-yl)methyl]-3-{1-[3-({[(2,2...)
Show SMILES CN1CCC(CNC(=O)c2cccc(c2)-c2ccc3n(cnc3c2)-c2cccc(NC(=O)NCC(F)(F)F)c2)CC1
Show InChI InChI=1S/C30H31F3N6O2/c1-38-12-10-20(11-13-38)17-34-28(40)23-5-2-4-21(14-23)22-8-9-27-26(15-22)36-19-39(27)25-7-3-6-24(16-25)37-29(41)35-18-30(31,32)33/h2-9,14-16,19-20H,10-13,17-18H2,1H3,(H,34,40)(H2,35,37,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356526
PNG
(N,N-Dimethyl-2-(4-{1-[3-({[(2,2,2-trifluoroethyl)a...)
Show SMILES CC(C(=O)N(C)C)c1ccc(cc1)-c1ccc2n(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H26F3N5O2/c1-17(25(36)34(2)3)18-7-9-19(10-8-18)20-11-12-24-23(13-20)32-16-35(24)22-6-4-5-21(14-22)33-26(37)31-15-27(28,29)30/h4-14,16-17H,15H2,1-3H3,(H2,31,33,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356537
PNG
(N-[3-(5-{t-[1-(Pyrrolidin-1-ylcarbonyl)piperidin-4...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1cnn(c1)C1CCN(CC1)C(=O)N1CCCC1
Show InChI InChI=1S/C29H31F3N8O2/c30-29(31,32)18-33-27(41)36-22-4-3-5-24(15-22)39-19-34-25-14-20(6-7-26(25)39)21-16-35-40(17-21)23-8-12-38(13-9-23)28(42)37-10-1-2-11-37/h3-7,14-17,19,23H,1-2,8-13,18H2,(H2,33,36,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356540
PNG
(N-[3-(5-{1-[1-(Tetrahydrofuran-2-ylcarbonyl)piperi...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1cnn(c1)C1CCN(CC1)C(=O)C1CCCO1
Show InChI InChI=1S/C29H30F3N7O3/c30-29(31,32)17-33-28(41)36-21-3-1-4-23(14-21)38-18-34-24-13-19(6-7-25(24)38)20-15-35-39(16-20)22-8-10-37(11-9-22)27(40)26-5-2-12-42-26/h1,3-4,6-7,13-16,18,22,26H,2,5,8-12,17H2,(H2,33,36,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356558
PNG
(N-{3-[7-(1-{1-[(3-hydroxycyclobutyl)carbonyl]piper...)
Show SMILES OC1CC(C1)C(=O)N1CCC(CC1)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C28H29F3N8O3/c29-28(30,31)16-33-27(42)36-21-3-1-2-17(8-21)24-14-32-25-11-19(12-35-39(24)25)20-13-34-38(15-20)22-4-6-37(7-5-22)26(41)18-9-23(40)10-18/h1-3,8,11-15,18,22-23,40H,4-7,9-10,16H2,(H2,33,36,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356560
PNG
(N-(2,2,2-trifluoroethyl)-N′-[3-(7-{1-[1-(3,3...)
Show SMILES OC(C(=O)N1CCC(CC1)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1)C(F)(F)F
Show InChI InChI=1S/C26H24F6N8O3/c27-25(28,29)14-34-24(43)37-18-3-1-2-15(8-18)20-12-33-21-9-16(10-36-40(20)21)17-11-35-39(13-17)19-4-6-38(7-5-19)23(42)22(41)26(30,31)32/h1-3,8-13,19,22,41H,4-7,14H2,(H2,34,37,43)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356599
PNG
(Cyclopropylmethyl 3-(cyanomethyl)-3-(4-{3-[3-({[(2...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)C(\C=N)=C\NC1(CC#N)CN(C1)C(=O)OCC1CC1
Show InChI InChI=1S/C28H28F3N9O3/c29-28(30,31)15-35-25(41)38-22-3-1-2-19(8-22)23-13-34-24-9-20(12-37-40(23)24)21(10-33)11-36-27(6-7-32)16-39(17-27)26(42)43-14-18-4-5-18/h1-3,8-13,18,33,36H,4-6,14-17H2,(H2,35,38,41)/b21-11+,33-10?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356613
PNG
(N-[3-(7-{4-[2-(4-Hydroxypiperidin-1-yl)-1-methyl-2...)
Show SMILES CC(C(=O)N1CCC(O)CC1)c1ccc(cc1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C29H29F3N6O3/c1-18(27(40)37-11-9-24(39)10-12-37)19-5-7-20(8-6-19)22-14-26-33-16-25(38(26)35-15-22)21-3-2-4-23(13-21)36-28(41)34-17-29(30,31)32/h2-8,13-16,18,24,39H,9-12,17H2,1H3,(H2,34,36,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356517
PNG
(N-[(1-Methyl-1H-imidazol-2-yl)methyl]-3-{1-[3-({[(...)
Show SMILES Cn1ccnc1CNC(=O)c1cccc(c1)-c1ccc2n(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C28H24F3N7O2/c1-37-11-10-32-25(37)15-33-26(39)20-5-2-4-18(12-20)19-8-9-24-23(13-19)35-17-38(24)22-7-3-6-21(14-22)36-27(40)34-16-28(29,30)31/h2-14,17H,15-16H2,1H3,(H,33,39)(H2,34,36,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356519
PNG
(N-(Tetrahydrofuran-2-ylmethyl)-4-{1-[3-({[(2,2,2-t...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1ccc(cc1)C(=O)NCC1CCCO1
Show InChI InChI=1S/C28H26F3N5O3/c29-28(30,31)16-33-27(38)35-21-3-1-4-22(14-21)36-17-34-24-13-20(10-11-25(24)36)18-6-8-19(9-7-18)26(37)32-15-23-5-2-12-39-23/h1,3-4,6-11,13-14,17,23H,2,5,12,15-16H2,(H,32,37)(H2,33,35,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356521
PNG
(N-[(1-Methylpiperidin-4-yl)methyl]-4-{1-[3-({[(2,2...)
Show SMILES CN1CCC(CNC(=O)c2ccc(cc2)-c2ccc3n(cnc3c2)-c2cccc(NC(=O)NCC(F)(F)F)c2)CC1
Show InChI InChI=1S/C30H31F3N6O2/c1-38-13-11-20(12-14-38)17-34-28(40)22-7-5-21(6-8-22)23-9-10-27-26(15-23)36-19-39(27)25-4-2-3-24(16-25)37-29(41)35-18-30(31,32)33/h2-10,15-16,19-20H,11-14,17-18H2,1H3,(H,34,40)(H2,35,37,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356524
PNG
(N-[(1-Methyl-1H-imidazol-2-yl)methyl]-4-{1-[3-({[(...)
Show SMILES Cn1ccnc1CNC(=O)c1ccc(cc1)-c1ccc2n(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C28H24F3N7O2/c1-37-12-11-32-25(37)15-33-26(39)19-7-5-18(6-8-19)20-9-10-24-23(13-20)35-17-38(24)22-4-2-3-21(14-22)36-27(40)34-16-28(29,30)31/h2-14,17H,15-16H2,1H3,(H,33,39)(H2,34,36,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356528
PNG
(N-(3-{5-[4-(1-Methyl-2-oxo-2-pyrrolidin-1-ylethyl)...)
Show SMILES CC(C(=O)N1CCCC1)c1ccc(cc1)-c1ccc2n(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C29H28F3N5O2/c1-19(27(38)36-13-2-3-14-36)20-7-9-21(10-8-20)22-11-12-26-25(15-22)34-18-37(26)24-6-4-5-23(16-24)35-28(39)33-17-29(30,31)32/h4-12,15-16,18-19H,2-3,13-14,17H2,1H3,(H2,33,35,39)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356536
PNG
(N-Pyridin-3-yl-4-(4-{1-[3-({([(2,2,2-trifluoroethy...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1cnn(c1)C1CCN(CC1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C30H28F3N9O2/c31-30(32,33)18-35-28(43)38-22-3-1-5-25(14-22)41-19-36-26-13-20(6-7-27(26)41)21-15-37-42(17-21)24-8-11-40(12-9-24)29(44)39-23-4-2-10-34-16-23/h1-7,10,13-17,19,24H,8-9,11-12,18H2,(H,39,44)(H2,35,38,43)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356538
PNG
(N-[3-(5-{1-[1-(Cyclopropylacetyl)piperidin-4-yl]-1...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1cnn(c1)C1CCN(CC1)C(=O)CC1CC1
Show InChI InChI=1S/C29H30F3N7O2/c30-29(31,32)17-33-28(41)36-22-2-1-3-24(14-22)38-18-34-25-13-20(6-7-26(25)38)21-15-35-39(16-21)23-8-10-37(11-9-23)27(40)12-19-4-5-19/h1-3,6-7,13-16,18-19,23H,4-5,8-12,17H2,(H2,33,36,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356542
PNG
(N-{3-[7-(1-{1-[(1-methyl-1H-pyrazol-3-yl)sulfonyl]...)
Show SMILES Cn1ccc(n1)S(=O)(=O)N1CCC(CC1)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H27F3N10O3S/c1-37-8-7-25(36-37)44(42,43)38-9-5-22(6-10-38)39-16-20(14-33-39)19-12-24-31-15-23(40(24)34-13-19)18-3-2-4-21(11-18)35-26(41)32-17-27(28,29)30/h2-4,7-8,11-16,22H,5-6,9-10,17H2,1H3,(H2,32,35,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356548
PNG
(N-[3-(7-{1-[1-(morpholin-4-ylcarbonyl)piperidin-4-...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C1CCN(CC1)C(=O)N1CCOCC1
Show InChI InChI=1S/C28H30F3N9O3/c29-28(30,31)18-33-26(41)36-22-3-1-2-19(12-22)24-16-32-25-13-20(14-35-40(24)25)21-15-34-39(17-21)23-4-6-37(7-5-23)27(42)38-8-10-43-11-9-38/h1-3,12-17,23H,4-11,18H2,(H2,33,36,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356550
PNG
(N-Benzyl-4-(4-{3-[3-({[(2,2,2-trifluoroethyl)amino...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C1CCN(CC1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C31H30F3N9O2/c32-31(33,34)20-37-29(44)40-25-8-4-7-22(13-25)27-18-35-28-14-23(16-39-43(27)28)24-17-38-42(19-24)26-9-11-41(12-10-26)30(45)36-15-21-5-2-1-3-6-21/h1-8,13-14,16-19,26H,9-12,15,20H2,(H,36,45)(H2,37,40,44)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356555
PNG
(N-[3-(7-{1-[1-(Cyanoacetyl)piperidin-4-yl]-1H-pyra...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C1CCN(CC1)C(=O)CC#N
Show InChI InChI=1S/C26H24F3N9O2/c27-26(28,29)16-32-25(40)35-20-3-1-2-17(10-20)22-14-31-23-11-18(12-34-38(22)23)19-13-33-37(15-19)21-5-8-36(9-6-21)24(39)4-7-30/h1-3,10-15,21H,4-6,8-9,16H2,(H2,32,35,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356568
PNG
(N-(Tetrahydro-2H-pyran-4-yl)-2-(4-{3-[3-({[(2,2,2-...)
Show SMILES CC(N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1)C(=O)NC1CCOCC1
Show InChI InChI=1S/C26H29F3N8O3/c1-16(24(38)35-20-5-7-40-8-6-20)31-12-19(11-30)18-10-23-32-14-22(37(23)34-13-18)17-3-2-4-21(9-17)36-25(39)33-15-26(27,28)29/h2-4,9-14,16,20,30-31H,5-8,15H2,1H3,(H,35,38)(H2,33,36,39)/b19-12+,30-11?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356579
PNG
(N-[3-(7-{1-[2-(3-Methoxypyrrolidin-1-yl)-1-methyl-...)
Show SMILES COC1CCN(C1)C(=O)C(C)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C26H27F3N8O3/c1-16(24(38)35-7-6-21(14-35)40-2)36-13-19(11-32-36)18-9-23-30-12-22(37(23)33-10-18)17-4-3-5-20(8-17)34-25(39)31-15-26(27,28)29/h3-5,8-13,16,21H,6-7,14-15H2,1-2H3,(H2,31,34,39)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356586
PNG
(N-[3-(7-{1-[3-(Cyanomethyl)-1-(methoxyacetyl)azeti...)
Show SMILES COCC(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C26H24F3N9O3/c1-41-13-23(39)36-15-25(16-36,5-6-30)37-12-19(10-33-37)18-8-22-31-11-21(38(22)34-9-18)17-3-2-4-20(7-17)35-24(40)32-14-26(27,28)29/h2-4,7-12H,5,13-16H2,1H3,(H2,32,35,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356590
PNG
(N-{3-[7-(1-{3-(Cyanomethyl)-1-[(1-methylcyclopropy...)
Show SMILES CC1(CC1)C(=O)N1CC(CC#N)(C1)N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C28H28F3N9O2/c1-26(5-6-26)24(41)39-16-27(17-39,7-8-32)36-12-20(11-33)19-10-23-34-14-22(40(23)37-13-19)18-3-2-4-21(9-18)38-25(42)35-15-28(29,30)31/h2-4,9-14,33,36H,5-7,15-17H2,1H3,(H2,35,38,42)/b20-12+,33-11?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356618
PNG
(N-(2-Morpholin-4-ylethyl)-2-(4-{3-[3-({[(2,2,2-tri...)
Show SMILES CC(C(=O)NCCN1CCOCC1)c1ccc(cc1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C30H32F3N7O3/c1-20(28(41)34-9-10-39-11-13-43-14-12-39)21-5-7-22(8-6-21)24-16-27-35-18-26(40(27)37-17-24)23-3-2-4-25(15-23)38-29(42)36-19-30(31,32)33/h2-8,15-18,20H,9-14,19H2,1H3,(H,34,41)(H2,36,38,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356541
PNG
(N-[3-(7-{1-[1-(Methoxyacetyl)piperidin-4-yl]-1H-py...)
Show SMILES COCC(=O)N1CCC(CC1)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C26H27F3N8O3/c1-40-15-24(38)35-7-5-21(6-8-35)36-14-19(12-32-36)18-10-23-30-13-22(37(23)33-11-18)17-3-2-4-20(9-17)34-25(39)31-16-26(27,28)29/h2-4,9-14,21H,5-8,15-16H2,1H3,(H2,31,34,39)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356545
PNG
(N-[3-(7-{1-[1-(Benzylsulfonyl)piperidin-4-yl]-1H-p...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C1CCN(CC1)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C30H29F3N8O3S/c31-30(32,33)20-35-29(42)38-25-8-4-7-22(13-25)27-17-34-28-14-23(15-37-41(27)28)24-16-36-40(18-24)26-9-11-39(12-10-26)45(43,44)19-21-5-2-1-3-6-21/h1-8,13-18,26H,9-12,19-20H2,(H2,35,38,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356556
PNG
(N-{3-[7-(1-{1-[(1-Cyanocyclopropyl)carbonyl]piperi...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C1CCN(CC1)C(=O)C1(CC1)C#N
Show InChI InChI=1S/C28H26F3N9O2/c29-28(30,31)17-34-26(42)37-21-3-1-2-18(10-21)23-14-33-24-11-19(12-36-40(23)24)20-13-35-39(15-20)22-4-8-38(9-5-22)25(41)27(16-32)6-7-27/h1-3,10-15,22H,4-9,17H2,(H2,34,37,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356564
PNG
(N-[3-(7-{6-[4-(pyrrolidin-1-ylcarbonyl)piperazin-1...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1ccc(nc1)N1CCN(CC1)C(=O)N1CCCC1
Show InChI InChI=1S/C29H30F3N9O2/c30-29(31,32)19-35-27(42)37-23-5-3-4-20(14-23)24-18-34-26-15-22(17-36-41(24)26)21-6-7-25(33-16-21)38-10-12-40(13-11-38)28(43)39-8-1-2-9-39/h3-7,14-18H,1-2,8-13,19H2,(H2,35,37,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356591
PNG
(N-[3-(7-{1-[1-[(1-Cyanocyclopropyl)carbonyl]-3-(cy...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)C(\C=N)=C\NC1(CC#N)CN(C1)C(=O)C1(CC1)C#N
Show InChI InChI=1S/C28H25F3N10O2/c29-28(30,31)15-36-25(43)39-21-3-1-2-18(8-21)22-13-35-23-9-19(12-38-41(22)23)20(10-33)11-37-27(6-7-32)16-40(17-27)24(42)26(14-34)4-5-26/h1-3,8-13,33,37H,4-6,15-17H2,(H2,36,39,43)/b20-11+,33-10?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356596
PNG
(N-[3-(7-{1-[3-(Cyanomethyl)-1-(morpholin-4-ylcarbo...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)C(\C=N)=C\NC1(CC#N)CN(C1)C(=O)N1CCOCC1
Show InChI InChI=1S/C28H29F3N10O3/c29-28(30,31)16-35-25(42)38-22-3-1-2-19(10-22)23-15-34-24-11-20(14-37-41(23)24)21(12-33)13-36-27(4-5-32)17-40(18-27)26(43)39-6-8-44-9-7-39/h1-3,10-15,33,36H,4,6-9,16-18H2,(H2,35,38,42)/b21-13+,33-12?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356603
PNG
(N-(3-{7-[1-(2-Cyano-1-cyclopropylethyl)-1H-pyrazol...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C(CC#N)C1CC1
Show InChI InChI=1S/C24H21F3N8O/c25-24(26,27)14-30-23(36)33-19-3-1-2-16(8-19)21-12-29-22-9-17(10-32-35(21)22)18-11-31-34(13-18)20(6-7-28)15-4-5-15/h1-3,8-13,15,20H,4-6,14H2,(H2,30,33,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356604
PNG
(N-(3-{7-[1-(2-Cyano-1-phenylethyl)-1H-pyrazol-4-yl...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C(CC#N)c1ccccc1
Show InChI InChI=1S/C27H21F3N8O/c28-27(29,30)17-33-26(39)36-22-8-4-7-19(11-22)24-15-32-25-12-20(13-35-38(24)25)21-14-34-37(16-21)23(9-10-31)18-5-2-1-3-6-18/h1-8,11-16,23H,9,17H2,(H2,33,36,39)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356610
PNG
(N,N-Dimethyl-2-(4-{3-[3-({[(2,2,2-trifluoroethyl)a...)
Show SMILES CC(C(=O)N(C)C)c1ccc(cc1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C26H25F3N6O2/c1-16(24(36)34(2)3)17-7-9-18(10-8-17)20-12-23-30-14-22(35(23)32-13-20)19-5-4-6-21(11-19)33-25(37)31-15-26(27,28)29/h4-14,16H,15H2,1-3H3,(H2,31,33,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356615
PNG
(N-[3-(7-{4-[2-(3-Hydroxyazetidin-1-yl)-1-methyl-2-...)
Show SMILES CC(C(=O)N1CC(O)C1)c1ccc(cc1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H25F3N6O3/c1-16(25(38)35-13-22(37)14-35)17-5-7-18(8-6-17)20-10-24-31-12-23(36(24)33-11-20)19-3-2-4-21(9-19)34-26(39)32-15-27(28,29)30/h2-12,16,22,37H,13-15H2,1H3,(H2,32,34,39)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356512
PNG
(Cyclopropylmethyl 3-{1-[3-({[(2,2,2-trifluoroethyl...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1cccc(c1)C(=O)NCC1CC1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)15-32-26(37)34-21-5-2-6-22(13-21)35-16-33-23-12-19(9-10-24(23)35)18-3-1-4-20(11-18)25(36)31-14-17-7-8-17/h1-6,9-13,16-17H,7-8,14-15H2,(H,31,36)(H2,32,34,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356516
PNG
(N-(Pyridin-3-ylmethyl)-3-{1-[3-({[(2,2,2-trifluoro...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1cccc(c1)C(=O)NCc1cccnc1
Show InChI InChI=1S/C29H23F3N6O2/c30-29(31,32)17-35-28(40)37-23-7-2-8-24(14-23)38-18-36-25-13-21(9-10-26(25)38)20-5-1-6-22(12-20)27(39)34-16-19-4-3-11-33-15-19/h1-15,18H,16-17H2,(H,34,39)(H2,35,37,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356532
PNG
(N-[3-(5-{1-[1-(Cyclopropylmethyl)piperidin-4-yl]-1...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1cnn(c1)C1CCN(CC2CC2)CC1
Show InChI InChI=1S/C28H30F3N7O/c29-28(30,31)17-32-27(39)35-22-2-1-3-24(13-22)37-18-33-25-12-20(6-7-26(25)37)21-14-34-38(16-21)23-8-10-36(11-9-23)15-19-4-5-19/h1-3,6-7,12-14,16,18-19,23H,4-5,8-11,15,17H2,(H2,32,35,39)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356533
PNG
(N-[3-(5-{1-[1-(Cyanomethyl)-2,2,2-trifluoroethyl]-...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1cnn(c1)C(CC#N)C(F)(F)F
Show InChI InChI=1S/C23H17F6N7O/c24-22(25,26)12-31-21(37)34-16-2-1-3-17(9-16)35-13-32-18-8-14(4-5-19(18)35)15-10-33-36(11-15)20(6-7-30)23(27,28)29/h1-5,8-11,13,20H,6,12H2,(H2,31,34,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356535
PNG
(N-{3-[5-(1-{1-[(1-Methyl-1H-pyrazol-3-yl)sulfonyl]...)
Show SMILES Cn1ccc(n1)S(=O)(=O)N1CCC(CC1)n1cc(cn1)-c1ccc2n(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C28H28F3N9O3S/c1-37-10-9-26(36-37)44(42,43)38-11-7-22(8-12-38)40-16-20(15-34-40)19-5-6-25-24(13-19)33-18-39(25)23-4-2-3-21(14-23)35-27(41)32-17-28(29,30)31/h2-6,9-10,13-16,18,22H,7-8,11-12,17H2,1H3,(H2,32,35,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356543
PNG
(N-{3-[7-(1-{1-[(1-Methyl-1H-pyrazol-4-yl)carbonyl]...)
Show SMILES Cn1cc(cn1)C(=O)N1CCC(CC1)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C28H27F3N10O2/c1-38-15-21(13-34-38)26(42)39-7-5-23(6-8-39)40-16-20(12-35-40)19-10-25-32-14-24(41(25)36-11-19)18-3-2-4-22(9-18)37-27(43)33-17-28(29,30)31/h2-4,9-16,23H,5-8,17H2,1H3,(H2,33,37,43)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356544
PNG
(N-{3-[7-(1-{1-[(Dimethylamino)acetyl]piperidin-4-y...)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H30F3N9O2/c1-36(2)16-25(40)37-8-6-22(7-9-37)38-15-20(13-33-38)19-11-24-31-14-23(39(24)34-12-19)18-4-3-5-21(10-18)35-26(41)32-17-27(28,29)30/h3-5,10-15,22H,6-9,16-17H2,1-2H3,(H2,32,35,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356546
PNG
(N-[3-(7-{1-[1-(cyclopentylacetyl)piperidin-4-yl]-1...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C1CCN(CC1)C(=O)CC1CCCC1
Show InChI InChI=1S/C30H33F3N8O2/c31-30(32,33)19-35-29(43)38-24-7-3-6-21(13-24)26-17-34-27-14-22(15-37-41(26)27)23-16-36-40(18-23)25-8-10-39(11-9-25)28(42)12-20-4-1-2-5-20/h3,6-7,13-18,20,25H,1-2,4-5,8-12,19H2,(H2,35,38,43)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356553
PNG
(N-{3-[7-(1-{1-[(1-Methylcyclopropyl)carbonyl]piper...)
Show SMILES CC1(CC1)C(=O)N1CCC(CC1)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C28H29F3N8O2/c1-27(7-8-27)25(40)37-9-5-22(6-10-37)38-16-20(14-34-38)19-12-24-32-15-23(39(24)35-13-19)18-3-2-4-21(11-18)36-26(41)33-17-28(29,30)31/h2-4,11-16,22H,5-10,17H2,1H3,(H2,33,36,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356567
PNG
(N,N-Dimethyl-2-(4-{3-[3-({[(2,2,2-trifluoroethyl)a...)
Show SMILES CC(N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1)C(=O)N(C)C
Show InChI InChI=1S/C23H25F3N8O2/c1-14(21(35)33(2)3)28-10-17(9-27)16-8-20-29-12-19(34(20)31-11-16)15-5-4-6-18(7-15)32-22(36)30-13-23(24,25)26/h4-12,14,27-28H,13H2,1-3H3,(H2,30,32,36)/b17-10+,27-9?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356569
PNG
(N-(3-{7-[1-(1-Methyl-2-morpholin-4-yl-2-oxoethyl)-...)
Show SMILES CC(N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C25H27F3N8O3/c1-16(23(37)35-5-7-39-8-6-35)30-12-19(11-29)18-10-22-31-14-21(36(22)33-13-18)17-3-2-4-20(9-17)34-24(38)32-15-25(26,27)28/h2-4,9-14,16,29-30H,5-8,15H2,1H3,(H2,32,34,38)/b19-12+,29-11?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356572
PNG
(N-(Pyridin-2-ylmethyl)-2-(4-{3-[3-({[(2,2,2-triflu...)
Show SMILES CC(N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1)C(=O)NCc1ccccn1
Show InChI InChI=1S/C27H26F3N9O2/c1-17(25(40)35-14-22-6-2-3-8-32-22)33-12-20(11-31)19-10-24-34-15-23(39(24)37-13-19)18-5-4-7-21(9-18)38-26(41)36-16-27(28,29)30/h2-13,15,17,31,33H,14,16H2,1H3,(H,35,40)(H2,36,38,41)/b20-12+,31-11?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356574
PNG
(N-(2-Hydroxypropyl)-2-(4-{3-[3-({[(2,2,2-trifluoro...)
Show SMILES CC(O)CNC(=O)C(C)N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C24H27F3N8O3/c1-14(36)9-31-22(37)15(2)29-10-18(8-28)17-7-21-30-12-20(35(21)33-11-17)16-4-3-5-19(6-16)34-23(38)32-13-24(25,26)27/h3-8,10-12,14-15,28-29,36H,9,13H2,1-2H3,(H,31,37)(H2,32,34,38)/b18-10+,28-8?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356580
PNG
(N-[3-(7-{1-[2-(4-Methoxypiperidin-1-yl)-1-methyl-2...)
Show SMILES COC1CCN(CC1)C(=O)C(C)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H29F3N8O3/c1-17(25(39)36-8-6-22(41-2)7-9-36)37-15-20(13-33-37)19-11-24-31-14-23(38(24)34-12-19)18-4-3-5-21(10-18)35-26(40)32-16-27(28,29)30/h3-5,10-15,17,22H,6-9,16H2,1-2H3,(H2,32,35,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356583
PNG
(N-[3-(7-{1-[2-(3-Cyanoazetidin-1-yl)-1-methyl-2-ox...)
Show SMILES CC(C(=O)N1CC(C1)C#N)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C25H22F3N9O2/c1-15(23(38)35-11-16(7-29)12-35)36-13-19(9-32-36)18-6-22-30-10-21(37(22)33-8-18)17-3-2-4-20(5-17)34-24(39)31-14-25(26,27)28/h2-6,8-10,13,15-16H,11-12,14H2,1H3,(H2,31,34,39)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356587
PNG
(N-{3-[7-(1-{3-(Cyanomethyl)-1-[(dimethylamino)acet...)
Show SMILES CN(C)CC(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H27F3N10O2/c1-37(2)14-24(41)38-16-26(17-38,6-7-31)39-13-20(11-34-39)19-9-23-32-12-22(40(23)35-10-19)18-4-3-5-21(8-18)36-25(42)33-15-27(28,29)30/h3-5,8-13H,6,14-17H2,1-2H3,(H2,33,36,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356598
PNG
(3-(Cyanomethyl)-N-(cyclopropylmethyl)-3-(4-{3-[3-(...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)C(\C=N)=C\NC1(CC#N)CN(C1)C(=O)NCC1CC1
Show InChI InChI=1S/C28H29F3N10O2/c29-28(30,31)15-36-25(42)39-22-3-1-2-19(8-22)23-14-34-24-9-20(13-38-41(23)24)21(10-33)12-37-27(6-7-32)16-40(17-27)26(43)35-11-18-4-5-18/h1-3,8-10,12-14,18,33,37H,4-6,11,15-17H2,(H,35,43)(H2,36,39,42)/b21-12+,33-10?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356616
PNG
(N-(3-{7-[4-(1-Methyl-2-morpholin-4-yl-2-oxoethyl)p...)
Show SMILES CC(C(=O)N1CCOCC1)c1ccc(cc1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C28H27F3N6O3/c1-18(26(38)36-9-11-40-12-10-36)19-5-7-20(8-6-19)22-14-25-32-16-24(37(25)34-15-22)21-3-2-4-23(13-21)35-27(39)33-17-28(29,30)31/h2-8,13-16,18H,9-12,17H2,1H3,(H2,33,35,39)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356522
PNG
(N-(2-Morpholin-4-ylethyl)-4-{1-[3-({[(2,2,2-triflu...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1ccc(cc1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C29H29F3N6O3/c30-29(31,32)18-34-28(40)36-23-2-1-3-24(17-23)38-19-35-25-16-22(8-9-26(25)38)20-4-6-21(7-5-20)27(39)33-10-11-37-12-14-41-15-13-37/h1-9,16-17,19H,10-15,18H2,(H,33,39)(H2,34,36,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356552
PNG
(N-[3-(7-{1-[1-(Cyclopropylacetyl)piperidin-4-yl]-1...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C1CCN(CC1)C(=O)CC1CC1
Show InChI InChI=1S/C28H29F3N8O2/c29-28(30,31)17-33-27(41)36-22-3-1-2-19(11-22)24-15-32-25-12-20(13-35-39(24)25)21-14-34-38(16-21)23-6-8-37(9-7-23)26(40)10-18-4-5-18/h1-3,11-16,18,23H,4-10,17H2,(H2,33,36,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356557
PNG
(N-[3-(7-{1-[1-(3-Cyclopropylpropanoyl)piperidin-4-...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C1CCN(CC1)C(=O)CCC1CC1
Show InChI InChI=1S/C29H31F3N8O2/c30-29(31,32)18-34-28(42)37-23-3-1-2-20(12-23)25-16-33-26-13-21(14-36-40(25)26)22-15-35-39(17-22)24-8-10-38(11-9-24)27(41)7-6-19-4-5-19/h1-3,12-17,19,24H,4-11,18H2,(H2,34,37,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356573
PNG
(N-[2-(2-Oxopyrrolidin-1-yl)ethyl]-2-(4-{3-[3-({[(2...)
Show SMILES CC(N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1)C(=O)NCCN1CCCC1=O
Show InChI InChI=1S/C27H30F3N9O3/c1-17(25(41)32-7-9-38-8-3-6-24(38)40)33-13-20(12-31)19-11-23-34-15-22(39(23)36-14-19)18-4-2-5-21(10-18)37-26(42)35-16-27(28,29)30/h2,4-5,10-15,17,31,33H,3,6-9,16H2,1H3,(H,32,41)(H2,35,37,42)/b20-13+,31-12?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356588
PNG
(N-[3-(7-{1-[1-(Cyanoacetyl)-3-(cyanomethyl)azetidi...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)C(\C=N)=C\NC1(CC#N)CN(C1)C(=O)CC#N
Show InChI InChI=1S/C26H23F3N10O2/c27-26(28,29)14-34-24(41)37-20-3-1-2-17(8-20)21-13-33-22-9-18(12-36-39(21)22)19(10-32)11-35-25(5-7-31)15-38(16-25)23(40)4-6-30/h1-3,8-13,32,35H,4-5,14-16H2,(H2,34,37,41)/b19-11+,32-10?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356589
PNG
(N-[3-(7-{1-[3-(Cyanomethyl)-1-(cyclopropylacetyl)a...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)C(\C=N)=C\NC1(CC#N)CN(C1)C(=O)CC1CC1
Show InChI InChI=1S/C28H28F3N9O2/c29-28(30,31)15-35-26(42)38-22-3-1-2-19(9-22)23-14-34-24-10-20(13-37-40(23)24)21(11-33)12-36-27(6-7-32)16-39(17-27)25(41)8-18-4-5-18/h1-3,9-14,18,33,36H,4-6,8,15-17H2,(H2,35,38,42)/b21-12+,33-11?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356592
PNG
(N-[3-(7-{1-[3-(Cyanomethyl)-1-(tetrahydrofuran-2-y...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)C(\C=N)=C\NC1(CC#N)CN(C1)C(=O)CC1CCCO1
Show InChI InChI=1S/C29H30F3N9O3/c30-29(31,32)16-36-27(43)39-22-4-1-3-19(9-22)24-15-35-25-10-20(14-38-41(24)25)21(12-34)13-37-28(6-7-33)17-40(18-28)26(42)11-23-5-2-8-44-23/h1,3-4,9-10,12-15,23,34,37H,2,5-6,8,11,16-18H2,(H2,36,39,43)/b21-13+,34-12?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356593
PNG
(N-[3-(7-{1-[3-(Cyanomethyl)-1-(tetrahydrofuran-3-y...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)C(\C=N)=C\NC1(CC#N)CN(C1)C(=O)C1CCOC1
Show InChI InChI=1S/C28H28F3N9O3/c29-28(30,31)15-35-26(42)38-22-3-1-2-18(8-22)23-13-34-24-9-20(12-37-40(23)24)21(10-33)11-36-27(5-6-32)16-39(17-27)25(41)19-4-7-43-14-19/h1-3,8-13,19,33,36H,4-5,7,14-17H2,(H2,35,38,42)/b21-11+,33-10?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356595
PNG
(3-(Cyanomethyl)-N-phenyl-3-(4-{3-[3-({[(2,2,2-trif...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)C(\C=N)=C\NC1(CC#N)CN(C1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C30H27F3N10O2/c31-30(32,33)17-37-27(44)40-24-8-4-5-20(11-24)25-16-36-26-12-21(15-39-43(25)26)22(13-35)14-38-29(9-10-34)18-42(19-29)28(45)41-23-6-2-1-3-7-23/h1-8,11-16,35,38H,9,17-19H2,(H,41,45)(H2,37,40,44)/b22-14+,35-13?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356597
PNG
(N-[3-(7-{1-[3-(Cyanomethyl)-1-(pyrrolidin-1-ylcarb...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)C(\C=N)=C\NC1(CC#N)CN(C1)C(=O)N1CCCC1
Show InChI InChI=1S/C28H29F3N10O2/c29-28(30,31)16-35-25(42)38-22-5-3-4-19(10-22)23-15-34-24-11-20(14-37-41(23)24)21(12-33)13-36-27(6-7-32)17-40(18-27)26(43)39-8-1-2-9-39/h3-5,10-15,33,36H,1-2,6,8-9,16-18H2,(H2,35,38,42)/b21-13+,33-12?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356617
PNG
(N-{3-[7-(4-{2-[(2S)-2-(Hydroxymethyl)pyrrolidin-1-...)
Show SMILES CC(C(=O)N1CCC[C@H]1CO)c1ccc(cc1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C29H29F3N6O3/c1-18(27(40)37-11-3-6-24(37)16-39)19-7-9-20(10-8-19)22-13-26-33-15-25(38(26)35-14-22)21-4-2-5-23(12-21)36-28(41)34-17-29(30,31)32/h2,4-5,7-10,12-15,18,24,39H,3,6,11,16-17H2,1H3,(H2,34,36,41)/t18?,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356513
PNG
(N-(Tetrahydrofuran-2-ylmethyl)-3-{1-[3-({[(2,2,2-t...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1cccc(c1)C(=O)NCC1CCCO1
Show InChI InChI=1S/C28H26F3N5O3/c29-28(30,31)16-33-27(38)35-21-6-2-7-22(14-21)36-17-34-24-13-19(9-10-25(24)36)18-4-1-5-20(12-18)26(37)32-15-23-8-3-11-39-23/h1-2,4-7,9-10,12-14,17,23H,3,8,11,15-16H2,(H,32,37)(H2,33,35,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356523
PNG
(N-(Pyridin-3-ylmethyl)-4-{1-[3-({[(2,2,2-trifluoro...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1ccc(cc1)C(=O)NCc1cccnc1
Show InChI InChI=1S/C29H23F3N6O2/c30-29(31,32)17-35-28(40)37-23-4-1-5-24(14-23)38-18-36-25-13-22(10-11-26(25)38)20-6-8-21(9-7-20)27(39)34-16-19-3-2-12-33-15-19/h1-15,18H,16-17H2,(H,34,39)(H2,35,37,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356534
PNG
(N-{3-[5-(1-{1-[(1-Methyl-1H-pyrazol-4-yl)carbonyl]...)
Show SMILES Cn1cc(cn1)C(=O)N1CCC(CC1)n1cc(cn1)-c1ccc2n(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C29H28F3N9O2/c1-38-15-21(14-35-38)27(42)39-9-7-23(8-10-39)41-16-20(13-36-41)19-5-6-26-25(11-19)34-18-40(26)24-4-2-3-22(12-24)37-28(43)33-17-29(30,31)32/h2-6,11-16,18,23H,7-10,17H2,1H3,(H2,33,37,43)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356566
PNG
(N-Methyl-2-(4-{3-[3-({[(2,2,2-trifluoroethyl)amino...)
Show SMILES CNC(=O)C(C)N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C22H23F3N8O2/c1-13(20(34)27-2)28-9-16(8-26)15-7-19-29-11-18(33(19)31-10-15)14-4-3-5-17(6-14)32-21(35)30-12-22(23,24)25/h3-11,13,26,28H,12H2,1-2H3,(H,27,34)(H2,30,32,35)/b16-9+,26-8?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356575
PNG
(N-[3-(7-{1-[2-(3-Hydroxyazetidin-1-yl)-1-methyl-2-...)
Show SMILES CC(N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1)C(=O)N1CC(O)C1
Show InChI InChI=1S/C24H25F3N8O3/c1-14(22(37)34-11-19(36)12-34)29-8-17(7-28)16-6-21-30-10-20(35(21)32-9-16)15-3-2-4-18(5-15)33-23(38)31-13-24(25,26)27/h2-10,14,19,28-29,36H,11-13H2,1H3,(H2,31,33,38)/b17-8+,28-7?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356577
PNG
(N-(Cyanomethyl)-2-(4-{3-[3-({[(2,2,2-trifluoroethy...)
Show SMILES CC(C(=O)NCC#N)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C23H20F3N9O2/c1-14(21(36)28-6-5-27)34-12-17(10-31-34)16-8-20-29-11-19(35(20)32-9-16)15-3-2-4-18(7-15)33-22(37)30-13-23(24,25)26/h2-4,7-12,14H,6,13H2,1H3,(H,28,36)(H2,30,33,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356578
PNG
(N-[3-(7-{1-[2-(3-Cyanopyrrolidin-1-yl)-1-methyl-2-...)
Show SMILES CC(C(=O)N1CCC(C1)C#N)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C26H24F3N9O2/c1-16(24(39)36-6-5-17(9-30)13-36)37-14-20(11-33-37)19-8-23-31-12-22(38(23)34-10-19)18-3-2-4-21(7-18)35-25(40)32-15-26(27,28)29/h2-4,7-8,10-12,14,16-17H,5-6,13,15H2,1H3,(H2,32,35,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356581
PNG
(N-[3-(7-{1-[2-(4-Cyanopiperidin-1-yl)-1-methyl-2-o...)
Show SMILES CC(C(=O)N1CCC(CC1)C#N)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H26F3N9O2/c1-17(25(40)37-7-5-18(11-31)6-8-37)38-15-21(13-34-38)20-10-24-32-14-23(39(24)35-12-20)19-3-2-4-22(9-19)36-26(41)33-16-27(28,29)30/h2-4,9-10,12-15,17-18H,5-8,16H2,1H3,(H2,33,36,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356584
PNG
(N-{3-[7-(1-{3-(Cyanomethyl)-1-[(1-methyl-1H-pyrazo...)
Show SMILES Cn1ccc(n1)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H24F3N11O3S/c1-38-8-5-24(37-38)45(43,44)39-16-26(17-39,6-7-31)40-14-20(12-34-40)19-10-23-32-13-22(41(23)35-11-19)18-3-2-4-21(9-18)36-25(42)33-15-27(28,29)30/h2-5,8-14H,6,15-17H2,1H3,(H2,33,36,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356600
PNG
(N-(3-{7-[1-(2-Cyano-1-methylethyl)-1H-pyrazol-4-yl...)
Show SMILES CC(CC#N)N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C22H21F3N8O/c1-14(5-6-26)28-10-17(9-27)16-8-20-29-12-19(33(20)31-11-16)15-3-2-4-18(7-15)32-21(34)30-13-22(23,24)25/h2-4,7-12,14,27-28H,5,13H2,1H3,(H2,30,32,34)/b17-10+,27-9?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356515
PNG
(N-(2-Morpholin-4-ylethyl)-3-{1-[3-({[(2,2,2-triflu...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1cccc(c1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C29H29F3N6O3/c30-29(31,32)18-34-28(40)36-23-5-2-6-24(17-23)38-19-35-25-16-21(7-8-26(25)38)20-3-1-4-22(15-20)27(39)33-9-10-37-11-13-41-14-12-37/h1-8,15-17,19H,9-14,18H2,(H,33,39)(H2,34,36,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356520
PNG
(N-[(2-Hydroxycyclohexyl)methyl]-4-{1-[3-({[2,2,2-t...)
Show SMILES OC1CCCCC1CNC(=O)c1ccc(cc1)-c1ccc2n(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C30H30F3N5O3/c31-30(32,33)17-35-29(41)37-23-5-3-6-24(15-23)38-18-36-25-14-21(12-13-26(25)38)19-8-10-20(11-9-19)28(40)34-16-22-4-1-2-7-27(22)39/h3,5-6,8-15,18,22,27,39H,1-2,4,7,16-17H2,(H,34,40)(H2,35,37,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356525
PNG
(N-Methyl-2-(4-{1-[3-({[(2,2,2-trifluoroethyl)amino...)
Show SMILES CNC(=O)C(C)c1ccc(cc1)-c1ccc2n(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C26H24F3N5O2/c1-16(24(35)30-2)17-6-8-18(9-7-17)19-10-11-23-22(12-19)32-15-34(23)21-5-3-4-20(13-21)33-25(36)31-14-26(27,28)29/h3-13,15-16H,14H2,1-2H3,(H,30,35)(H2,31,33,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356527
PNG
(N-(Cyclopropylmethyl)-2-(4-{{1-[3-(([(2,2,2-triflu...)
Show SMILES CC(C(=O)NCC1CC1)c1ccc(cc1)-c1ccc2n(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C29H28F3N5O2/c1-18(27(38)33-15-19-5-6-19)20-7-9-21(10-8-20)22-11-12-26-25(13-22)35-17-37(26)24-4-2-3-23(14-24)36-28(39)34-16-29(30,31)32/h2-4,7-14,17-19H,5-6,15-16H2,1H3,(H,33,38)(H2,34,36,39)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356529
PNG
(N-(Tetrahydrofuran-2-ylmethyl)-2-(4-{1-[3-({[(2,2,...)
Show SMILES CC(C(=O)NCC1CCCO1)c1ccc(cc1)-c1ccc2n(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C30H30F3N5O3/c1-19(28(39)34-16-25-6-3-13-41-25)20-7-9-21(10-8-20)22-11-12-27-26(14-22)36-18-38(27)24-5-2-4-23(15-24)37-29(40)35-17-30(31,32)33/h2,4-5,7-12,14-15,18-19,25H,3,6,13,16-17H2,1H3,(H,34,39)(H2,35,37,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356530
PNG
(N-[3-(5-{4-[2-(3-Cyanopyrrolidin-1-yl)-1-methyl-2-...)
Show SMILES CC(C(=O)N1CCC(C1)C#N)c1ccc(cc1)-c1ccc2n(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C30H27F3N6O2/c1-19(28(40)38-12-11-20(15-34)16-38)21-5-7-22(8-6-21)23-9-10-27-26(13-23)36-18-39(27)25-4-2-3-24(14-25)37-29(41)35-17-30(31,32)33/h2-10,13-14,18-20H,11-12,16-17H2,1H3,(H2,35,37,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356531
PNG
(N-[(1-Methyl-1H-imidazol-2-yl)methyl]-2-(4-{1-[3-(...)
Show SMILES CC(C(=O)NCc1nccn1C)c1ccc(cc1)-c1ccc2n(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C30H28F3N7O2/c1-19(28(41)35-16-27-34-12-13-39(27)2)20-6-8-21(9-7-20)22-10-11-26-25(14-22)37-18-40(26)24-5-3-4-23(15-24)38-29(42)36-17-30(31,32)33/h3-15,18-19H,16-17H2,1-2H3,(H,35,41)(H2,36,38,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356539
PNG
(N-[3-(5-{1-[1-(Cyanoacetyl)piperidin-4-yl]-1H-pyra...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1cnn(c1)C1CCN(CC1)C(=O)CC#N
Show InChI InChI=1S/C27H25F3N8O2/c28-27(29,30)16-32-26(40)35-20-2-1-3-22(13-20)37-17-33-23-12-18(4-5-24(23)37)19-14-34-38(15-19)21-7-10-36(11-8-21)25(39)6-9-31/h1-5,12-15,17,21H,6-8,10-11,16H2,(H2,32,35,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356549
PNG
(N-Pyridin-3-yl-4-(4-{3-[3-({[(2,2,2-trifluoroethyl...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C1CCN(CC1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C29H27F3N10O2/c30-29(31,32)18-35-27(43)38-22-4-1-3-19(11-22)25-16-34-26-12-20(13-37-42(25)26)21-14-36-41(17-21)24-6-9-40(10-7-24)28(44)39-23-5-2-8-33-15-23/h1-5,8,11-17,24H,6-7,9-10,18H2,(H,39,44)(H2,35,38,43)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356551
PNG
(N-(tetrahydrofuran-2-ylmethyl)-4-(4-{3-[3-({[(2,2,...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C1CCN(CC1)C(=O)NCC1CCCO1
Show InChI InChI=1S/C29H32F3N9O3/c30-29(31,32)18-35-27(42)38-22-4-1-3-19(11-22)25-16-33-26-12-20(13-37-41(25)26)21-14-36-40(17-21)23-6-8-39(9-7-23)28(43)34-15-24-5-2-10-44-24/h1,3-4,11-14,16-17,23-24H,2,5-10,15,18H2,(H,34,43)(H2,35,38,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356559
PNG
(N-[3-(7-{1-[1-(tetrahydrofuran-3-ylcarbonyl)piperi...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C1CCN(CC1)C(=O)C1CCOC1
Show InChI InChI=1S/C28H29F3N8O3/c29-28(30,31)17-33-27(41)36-22-3-1-2-18(10-22)24-14-32-25-11-20(12-35-39(24)25)21-13-34-38(15-21)23-4-7-37(8-5-23)26(40)19-6-9-42-16-19/h1-3,10-15,19,23H,4-9,16-17H2,(H2,33,36,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356561
PNG
(N-[3-(7-{1-[1-(tetrahydrofuran-2-ylacetyl)piperidi...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cnn(c1)C1CCN(CC1)C(=O)CC1CCCO1
Show InChI InChI=1S/C29H31F3N8O3/c30-29(31,32)18-34-28(42)37-22-4-1-3-19(11-22)25-16-33-26-12-20(14-36-40(25)26)21-15-35-39(17-21)23-6-8-38(9-7-23)27(41)13-24-5-2-10-43-24/h1,3-4,11-12,14-17,23-24H,2,5-10,13,18H2,(H2,34,37,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356605
PNG
(Trans-N-{[(2-hydroxycyclohexyl]methyl}-3-{3-[3-({(...)
Show SMILES O[C@@H]1CCCC[C@H]1CNC(=O)c1cccc(c1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C29H29F3N6O3/c30-29(31,32)17-35-28(41)37-23-9-4-7-19(12-23)24-16-33-26-13-22(15-36-38(24)26)18-6-3-8-20(11-18)27(40)34-14-21-5-1-2-10-25(21)39/h3-4,6-9,11-13,15-16,21,25,39H,1-2,5,10,14,17H2,(H,34,40)(H2,35,37,41)/t21-,25+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356562
PNG
(N-[3-(7-{6-[4-(methoxyacetyl)piperazin-1-yl]pyridi...)
Show SMILES COCC(=O)N1CCN(CC1)c1ccc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H27F3N8O3/c1-41-16-25(39)37-9-7-36(8-10-37)23-6-5-19(13-31-23)20-12-24-32-15-22(38(24)34-14-20)18-3-2-4-21(11-18)35-26(40)33-17-27(28,29)30/h2-6,11-15H,7-10,16-17H2,1H3,(H2,33,35,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356563
PNG
(N-[3-(7-{6-[4-(Cyclopentylacetyl)piperazin-1-yl]py...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1ccc(nc1)N1CCN(CC1)C(=O)CC1CCCC1
Show InChI InChI=1S/C31H33F3N8O2/c32-31(33,34)20-37-30(44)39-25-7-3-6-22(15-25)26-19-36-28-16-24(18-38-42(26)28)23-8-9-27(35-17-23)40-10-12-41(13-11-40)29(43)14-21-4-1-2-5-21/h3,6-9,15-19,21H,1-2,4-5,10-14,20H2,(H2,37,39,44)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356594
PNG
(N-[3-(7-{1-[3-(Cyanomethyl)-1-(cyclopropylmethyl)a...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)C(\C=N)=C\NC1(CC#N)CN(CC2CC2)C1
Show InChI InChI=1S/C27H28F3N9O/c28-27(29,30)15-34-25(40)37-22-3-1-2-19(8-22)23-13-33-24-9-20(12-36-39(23)24)21(10-32)11-35-26(6-7-31)16-38(17-26)14-18-4-5-18/h1-3,8-13,18,32,35H,4-6,14-17H2,(H2,34,37,40)/b21-11+,32-10?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356606
PNG
(US10213427, Example 95 | cis-N-{[(2-Hydroxycyclohe...)
Show SMILES O[C@H]1CCCC[C@H]1CNC(=O)c1cccc(c1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C29H29F3N6O3/c30-29(31,32)17-35-28(41)37-23-9-4-7-19(12-23)24-16-33-26-13-22(15-36-38(24)26)18-6-3-8-20(11-18)27(40)34-14-21-5-1-2-10-25(21)39/h3-4,6-9,11-13,15-16,21,25,39H,1-2,5,10,14,17H2,(H,34,40)(H2,35,37,41)/t21-,25-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356607
PNG
(N-(2-Fluorobenzyl)-3-[3-(3-{[(methylamino)carbonyl...)
Show SMILES CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cccc(c1)C(=O)NCc1ccccc1F
Show InChI InChI=1S/C28H23FN6O2/c1-30-28(37)34-23-10-5-8-19(13-23)25-17-31-26-14-22(16-33-35(25)26)18-7-4-9-20(12-18)27(36)32-15-21-6-2-3-11-24(21)29/h2-14,16-17H,15H2,1H3,(H,32,36)(H2,30,34,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>25n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM356608
PNG
(N-[1-(2-Fluorophenyl)ethyl]-3-[3-(3-{[(methylamino...)
Show SMILES CNC(=O)Nc1cccc(c1)-c1cnc2cc(cnn12)-c1cccc(c1)C(=O)NC(C)c1ccccc1F
Show InChI InChI=1S/C29H25FN6O2/c1-18(24-11-3-4-12-25(24)30)34-28(37)21-9-5-7-19(13-21)22-15-27-32-17-26(36(27)33-16-22)20-8-6-10-23(14-20)35-29(38)31-2/h3-18H,1-2H3,(H,34,37)(H2,31,35,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>25n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%