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Patent code US10214478

Compile Data Set for Download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ionotropic glutamate receptor NMDA1/2A/2B


(RAT)
BDBM356623
PNG
(US10214478, Compound NM-005)
Show SMILES CCC12CC3CC(N)(C1)CC(CCCO[N+]([O-])=O)(C3)C2
Show InChI InChI=1S/C15H26N2O3/c1-2-13-6-12-7-14(9-13,4-3-5-20-17(18)19)11-15(16,8-12)10-13/h12H,2-11,16H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6.06E+3n/an/an/an/a



TBA

US Patent


Assay Description
Isolated primary cerebellum granule cells of infant rats were inoculated in 96-well plates with 1.2105/well by using 10% FBS+25 mM KCl+2 mM Glutamin...


US Patent US10214478 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA1/2A/2B


(RAT)
BDBM356629
PNG
(US10214478, Compound NM-011)
Show SMILES NC12CC3CC(CCCO[N+]([O-])=O)(C1)CC(CCCO[N+]([O-])=O)(C3)C2
Show InChI InChI=1S/C16H27N3O6/c17-16-9-13-7-14(11-16,3-1-5-24-18(20)21)10-15(8-13,12-16)4-2-6-25-19(22)23/h13H,1-12,17H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.86E+3n/an/an/an/a



TBA

US Patent


Assay Description
Isolated primary cerebellum granule cells of infant rats were inoculated in 96-well plates with 1.2105/well by using 10% FBS+25 mM KCl+2 mM Glutamin...


US Patent US10214478 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA1/2A/2B


(RAT)
BDBM356630
PNG
(US10214478, Compound NM-012)
Show SMILES CC(CO[N+]([O-])=O)CC12CC3CC(N)(C1)CC(CC(C)CO[N+]([O-])=O)(C3)C2
Show InChI InChI=1S/C18H31N3O6/c1-13(8-26-20(22)23)3-16-5-15-6-17(10-16,12-18(19,7-15)11-16)4-14(2)9-27-21(24)25/h13-15H,3-12,19H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 9.30E+3n/an/an/an/a



TBA

US Patent


Assay Description
Isolated primary cerebellum granule cells of infant rats were inoculated in 96-well plates with 1.2105/well by using 10% FBS+25 mM KCl+2 mM Glutamin...


US Patent US10214478 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA1/2A/2B


(RAT)
BDBM356631
PNG
(Nitromemantine | US10214478, Compound YQW-036)
Show SMILES CCC12CC3(N)CC(CC)(C1)CC(C3)(C2)O[N+]([O-])=O
Show InChI InChI=1S/C14H24N2O3/c1-3-11-5-12(4-2)7-13(15,6-11)10-14(8-11,9-12)19-16(17)18/h3-10,15H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.14E+4n/an/an/an/a



TBA

US Patent


Assay Description
Isolated primary cerebellum granule cells of infant rats were inoculated in 96-well plates with 1.2105/well by using 10% FBS+25 mM KCl+2 mM Glutamin...


US Patent US10214478 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA1/2A/2B


(RAT)
BDBM356621
PNG
(US10214478, Compound NM-003)
Show SMILES CCC12CC3CC(N)(C1)CC(C3)(C2)O[N+]([O-])=O
Show InChI InChI=1S/C12H20N2O3/c1-2-10-3-9-4-11(13,6-10)8-12(5-9,7-10)17-14(15)16/h9H,2-8,13H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.54E+4n/an/an/an/a



TBA

US Patent


Assay Description
Isolated primary cerebellum granule cells of infant rats were inoculated in 96-well plates with 1.2105/well by using 10% FBS+25 mM KCl+2 mM Glutamin...


US Patent US10214478 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA1/2A/2B


(RAT)
BDBM356624
PNG
(US10214478, Compound NM-008)
Show SMILES NC12CC3CC(CO[N+]([O-])=O)(C1)CC(CO[N+]([O-])=O)(C3)C2
Show InChI InChI=1S/C12H19N3O6/c13-12-3-9-1-10(5-12,7-20-14(16)17)4-11(2-9,6-12)8-21-15(18)19/h9H,1-8,13H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.37E+3n/an/an/an/a



TBA

US Patent


Assay Description
Isolated primary cerebellum granule cells of infant rats were inoculated in 96-well plates with 1.2105/well by using 10% FBS+25 mM KCl+2 mM Glutamin...


US Patent US10214478 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA1/2A/2B


(RAT)
BDBM356620
PNG
(US10214478, Compound NM-002)
Show SMILES CC12CC3CC(N)(C1)CC(CO[N+]([O-])=O)(C3)C2
Show InChI InChI=1S/C12H20N2O3/c1-10-2-9-3-11(5-10,8-17-14(15)16)7-12(13,4-9)6-10/h9H,2-8,13H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.52E+4n/an/an/an/a



TBA

US Patent


Assay Description
Isolated primary cerebellum granule cells of infant rats were inoculated in 96-well plates with 1.2105/well by using 10% FBS+25 mM KCl+2 mM Glutamin...


US Patent US10214478 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA1/2A/2B


(RAT)
BDBM356622
PNG
(US10214478, Compound NM-004)
Show SMILES CCC12CC3CC(N)(C1)CC(CO[N+]([O-])=O)(C3)C2
Show InChI InChI=1S/C13H22N2O3/c1-2-11-3-10-4-12(6-11,9-18-15(16)17)8-13(14,5-10)7-11/h10H,2-9,14H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.12E+3n/an/an/an/a



TBA

US Patent


Assay Description
Isolated primary cerebellum granule cells of infant rats were inoculated in 96-well plates with 1.2105/well by using 10% FBS+25 mM KCl+2 mM Glutamin...


US Patent US10214478 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA1/2A/2B


(RAT)
BDBM356628
PNG
(US10214478, Compound NM-009)
Show SMILES NC12CC3CC(CCO[N+]([O-])=O)(C1)CC(CCO[N+]([O-])=O)(C3)C2
Show InChI InChI=1S/C14H23N3O6/c15-14-7-11-5-12(9-14,1-3-22-16(18)19)8-13(6-11,10-14)2-4-23-17(20)21/h11H,1-10,15H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.20E+3n/an/an/an/a



TBA

US Patent


Assay Description
Isolated primary cerebellum granule cells of infant rats were inoculated in 96-well plates with 1.2105/well by using 10% FBS+25 mM KCl+2 mM Glutamin...


US Patent US10214478 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA1/2A/2B


(RAT)
BDBM50062599
PNG
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | MEM...)
Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2
Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

US Patent
n/an/an/an/a 2.72E+3n/an/an/an/a



TBA

US Patent


Assay Description
Isolated primary cerebellum granule cells of infant rats were inoculated in 96-well plates with 1.2105/well by using 10% FBS+25 mM KCl+2 mM Glutamin...


US Patent US10214478 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA1/2A/2B


(RAT)
BDBM356619
PNG
(US10214478, Compound NM-001)
Show SMILES CC12CC3CC(N)(C1)CC(C3)(C2)O[N+]([O-])=O
Show InChI InChI=1S/C11H18N2O3/c1-9-2-8-3-10(12,5-9)7-11(4-8,6-9)16-13(14)15/h8H,2-7,12H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.46E+4n/an/an/an/a



TBA

US Patent


Assay Description
Isolated primary cerebellum granule cells of infant rats were inoculated in 96-well plates with 1.2105/well by using 10% FBS+25 mM KCl+2 mM Glutamin...


US Patent US10214478 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%