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Patent code US10214507

Compile Data Set for Download or QSAR
Found 138 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356638
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl) tetrahy...)
Show SMILES OC(CN1CCCNC1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C19H21N3O2/c23-14(12-21-11-5-10-20-19(21)24)13-22-17-8-3-1-6-15(17)16-7-2-4-9-18(16)22/h1-4,6-9,14,23H,5,10-13H2,(H,20,24)
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n/an/an/an/a 299n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356641
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CCN1CCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C20H21F2N3O2/c1-2-23-7-8-24(20(23)27)11-15(26)12-25-18-5-3-13(21)9-16(18)17-10-14(22)4-6-19(17)25/h3-6,9-10,15,26H,2,7-8,11-12H2,1H3
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n/an/an/an/a 1.11E+3n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356645
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES OC(CN1CCCN(C1=O)c1ccccc1)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C25H23F2N3O2/c26-17-7-9-23-21(13-17)22-14-18(27)8-10-24(22)30(23)16-20(31)15-28-11-4-12-29(25(28)32)19-5-2-1-3-6-19/h1-3,5-10,13-14,20,31H,4,11-12,15-16H2
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n/an/an/an/a 171n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356661
PNG
(1-cyclobutyl-3-(3- (3,6-difluoro-9H- carbazol-9-yl...)
Show SMILES CC(O)(CN1CCCN(C2CCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C24H27F2N3O2/c1-24(31,14-27-10-3-11-28(23(27)30)18-4-2-5-18)15-29-21-8-6-16(25)12-19(21)20-13-17(26)7-9-22(20)29/h6-9,12-13,18,31H,2-5,10-11,14-15H2,1H3
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n/an/an/an/a 816n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356669
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)imid- az...)
Show SMILES OC(CN1CCNC1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C18H19N3O2/c22-13(11-20-10-9-19-18(20)23)12-21-16-7-3-1-5-14(16)15-6-2-4-8-17(15)21/h1-8,13,22H,9-12H2,(H,19,23)
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n/an/an/an/a 325n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356688
PNG
(1-cyclopentyl-3-(3- (3,6-difluoro-9H- carbazol-9-y...)
Show SMILES OC(CN1CCN(C2CCCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C23H25F2N3O2/c24-15-5-7-21-19(11-15)20-12-16(25)6-8-22(20)28(21)14-18(29)13-26-9-10-27(23(26)30)17-3-1-2-4-17/h5-8,11-12,17-18,29H,1-4,9-10,13-14H2
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n/an/an/an/a 621n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356697
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC1CN(C)C(=O)N(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1
Show InChI InChI=1S/C21H23F2N3O2/c1-13-9-24(2)21(28)25(10-13)11-16(27)12-26-19-5-3-14(22)7-17(19)18-8-15(23)4-6-20(18)26/h3-8,13,16,27H,9-12H2,1-2H3
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n/an/an/an/a 833n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356699
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3- ethy...)
Show SMILES CCN1CCCN(CC(O)Cn2c3ccccc3c3ccccc23)C1=O
Show InChI InChI=1S/C21H25N3O2/c1-2-22-12-7-13-23(21(22)26)14-16(25)15-24-19-10-5-3-8-17(19)18-9-4-6-11-20(18)24/h3-6,8-11,16,25H,2,7,12-15H2,1H3
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n/an/an/an/a 568n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356919
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC(C)C1CN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C(=O)C1
Show InChI InChI=1S/C22H24F2N2O2/c1-13(2)14-7-22(28)25(10-14)11-17(27)12-26-20-5-3-15(23)8-18(20)19-9-16(24)4-6-21(19)26/h3-6,8-9,13-14,17,27H,7,10-12H2,1-2H3
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n/an/an/an/a 373n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356920
PNG
((S)-1-((R)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- ...)
Show SMILES C[C@H]1CCC(=O)N1C[C@H](O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C20H20F2N2O2/c1-12-2-7-20(26)23(12)10-15(25)11-24-18-5-3-13(21)8-16(18)17-9-14(22)4-6-19(17)24/h3-6,8-9,12,15,25H,2,7,10-11H2,1H3/t12-,15-/m0/s1
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n/an/an/an/a 830n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356927
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CCC1CN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C(=O)C1
Show InChI InChI=1S/C21H22F2N2O2/c1-2-13-7-21(27)24(10-13)11-16(26)12-25-19-5-3-14(22)8-17(19)18-9-15(23)4-6-20(18)25/h3-6,8-9,13,16,26H,2,7,10-12H2,1H3
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n/an/an/an/a 52n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356929
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CCC1CN(CC(C)(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C(=O)C1
Show InChI InChI=1S/C22H24F2N2O2/c1-3-14-8-21(27)25(11-14)12-22(2,28)13-26-19-6-4-15(23)9-17(19)18-10-16(24)5-7-20(18)26/h4-7,9-10,14,28H,3,8,11-13H2,1-2H3
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n/an/an/an/a 618n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356948
PNG
((S)-1-((S)-3-(9H- carbazol-9-yl)-2- hydroxy-2- met...)
Show SMILES C[C@@](O)(CN1CC[C@H](F)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C20H21FN2O2/c1-20(25,12-22-11-10-16(21)19(22)24)13-23-17-8-4-2-6-14(17)15-7-3-5-9-18(15)23/h2-9,16,25H,10-13H2,1H3/t16-,20+/m0/s1
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n/an/an/an/a 309n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356949
PNG
(4-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC(O)(CN1CCOCC1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C20H20F2N2O3/c1-20(26,11-23-6-7-27-10-19(23)25)12-24-17-4-2-13(21)8-15(17)16-9-14(22)3-5-18(16)24/h2-5,8-9,26H,6-7,10-12H2,1H3
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n/an/an/an/a 1.06E+3n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356965
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3- meth...)
Show SMILES COC1CCCN(CC(O)Cn2c3ccccc3c3ccccc23)C1=O
Show InChI InChI=1S/C21H24N2O3/c1-26-20-11-6-12-22(21(20)25)13-15(24)14-23-18-9-4-2-7-16(18)17-8-3-5-10-19(17)23/h2-5,7-10,15,20,24H,6,11-14H2,1H3
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n/an/an/an/a 331n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356967
PNG
((S)-1-((R)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)...)
Show SMILES C[C@H]1CCC(=O)N(C[C@H](O)Cn2c3ccccc3c3ccccc23)C1
Show InChI InChI=1S/C21H24N2O2/c1-15-10-11-21(25)22(12-15)13-16(24)14-23-19-8-4-2-6-17(19)18-7-3-5-9-20(18)23/h2-9,15-16,24H,10-14H2,1H3/t15-,16-/m0/s1
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n/an/an/an/a 748n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356970
PNG
((S)-1-((R)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- ...)
Show SMILES C[C@H]1CCC(=O)N(C[C@H](O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1
Show InChI InChI=1S/C21H22F2N2O2/c1-13-2-7-21(27)24(10-13)11-16(26)12-25-19-5-3-14(22)8-17(19)18-9-15(23)4-6-20(18)25/h3-6,8-9,13,16,26H,2,7,10-12H2,1H3/t13-,16-/m0/s1
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n/an/an/an/a 895n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356976
PNG
((R)-1-((R)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)...)
Show SMILES C[C@@H]1CCC(=O)N(C[C@H](O)Cn2c3ccccc3c3ccccc23)C1
Show InChI InChI=1S/C21H24N2O2/c1-15-10-11-21(25)22(12-15)13-16(24)14-23-19-8-4-2-6-17(19)18-7-3-5-9-20(18)23/h2-9,15-16,24H,10-14H2,1H3/t15-,16+/m1/s1
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n/an/an/an/a 280n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356977
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-6- meth...)
Show SMILES CC1CCCC(=O)N1CC(O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C21H24N2O2/c1-15-7-6-12-21(25)22(15)13-16(24)14-23-19-10-4-2-8-17(19)18-9-3-5-11-20(18)23/h2-5,8-11,15-16,24H,6-7,12-14H2,1H3
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n/an/an/an/a 541n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356981
PNG
((R)-1-((S)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)...)
Show SMILES C[C@@H]1CCC(=O)N(C[C@@H](O)Cn2c3ccccc3c3ccccc23)C1
Show InChI InChI=1S/C21H24N2O2/c1-15-10-11-21(25)22(12-15)13-16(24)14-23-19-8-4-2-6-17(19)18-7-3-5-9-20(18)23/h2-9,15-16,24H,10-14H2,1H3/t15-,16-/m1/s1
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n/an/an/an/a 838n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356983
PNG
((R)-1-((R)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- ...)
Show SMILES C[C@@H]1CCC(=O)N(C[C@H](O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1
Show InChI InChI=1S/C21H22F2N2O2/c1-13-2-7-21(27)24(10-13)11-16(26)12-25-19-5-3-14(22)8-17(19)18-9-15(23)4-6-20(18)25/h3-6,8-9,13,16,26H,2,7,10-12H2,1H3/t13-,16+/m1/s1
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n/an/an/an/a 397n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356984
PNG
(1-(3-(9H-carbazol- 9-yl)-2-hydroxy-2- methylpropyl...)
Show SMILES CC(O)(CN1CCCCC1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C21H24N2O2/c1-21(25,14-22-13-7-6-12-20(22)24)15-23-18-10-4-2-8-16(18)17-9-3-5-11-19(17)23/h2-5,8-11,25H,6-7,12-15H2,1H3
PDB

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n/an/an/an/a 523n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356991
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl) pyrroli...)
Show SMILES OC(CN1CCCC1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C19H20N2O2/c22-14(12-20-11-5-10-19(20)23)13-21-17-8-3-1-6-15(17)16-7-2-4-9-18(16)21/h1-4,6-9,14,22H,5,10-13H2
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356633
PNG
(1-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)piperidin-...)
Show SMILES OC(CN1CCCCC1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C20H22N2O2/c23-15(13-21-12-6-5-11-20(21)24)14-22-18-9-3-1-7-16(18)17-8-2-4-10-19(17)22/h1-4,7-10,15,23H,5-6,11-14H2
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356636
PNG
(US10214507, Compound 71)
Show SMILES OC(CN1CCCNC1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C19H19F2N3O2/c20-12-2-4-17-15(8-12)16-9-13(21)3-5-18(16)24(17)11-14(25)10-23-7-1-6-22-19(23)26/h2-5,8-9,14,25H,1,6-7,10-11H2,(H,22,26)
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356646
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES OC(CN1CCCC1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C19H18F2N2O2/c20-12-3-5-17-15(8-12)16-9-13(21)4-6-18(16)23(17)11-14(24)10-22-7-1-2-19(22)25/h3-6,8-9,14,24H,1-2,7,10-11H2
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356658
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES OC(CN1CCCC(F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C20H19F3N2O2/c21-12-3-5-18-15(8-12)16-9-13(22)4-6-19(16)25(18)11-14(26)10-24-7-1-2-17(23)20(24)27/h3-6,8-9,14,17,26H,1-2,7,10-11H2
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356676
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CCN1CCCN(CC(C)(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C22H25F2N3O2/c1-3-25-9-4-10-26(21(25)28)13-22(2,29)14-27-19-7-5-15(23)11-17(19)18-12-16(24)6-8-20(18)27/h5-8,11-12,29H,3-4,9-10,13-14H2,1-2H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356711
PNG
(US10214507, Compound 101)
Show SMILES CC1CCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C(=O)N1C
Show InChI InChI=1S/C21H23F2N3O2/c1-13-7-8-25(21(28)24(13)2)11-16(27)12-26-19-5-3-14(22)9-17(19)18-10-15(23)4-6-20(18)26/h3-6,9-10,13,16,27H,7-8,11-12H2,1-2H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356712
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CCC1CCC(=O)N1CC(C)(O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C22H24F2N2O2/c1-3-16-6-9-21(27)25(16)12-22(2,28)13-26-19-7-4-14(23)10-17(19)18-11-15(24)5-8-20(18)26/h4-5,7-8,10-11,16,28H,3,6,9,12-13H2,1-2H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356719
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC1CCN(CC(C)(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C(=O)C1
Show InChI InChI=1S/C22H24F2N2O2/c1-14-7-8-25(21(27)9-14)12-22(2,28)13-26-19-5-3-15(23)10-17(19)18-11-16(24)4-6-20(18)26/h3-6,10-11,14,28H,7-9,12-13H2,1-2H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356723
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC1CCC(=O)N(CC(C)(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1
Show InChI InChI=1S/C22H24F2N2O2/c1-14-3-8-21(27)25(11-14)12-22(2,28)13-26-19-6-4-15(23)9-17(19)18-10-16(24)5-7-20(18)26/h4-7,9-10,14,28H,3,8,11-13H2,1-2H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356725
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC1CCCC(=O)N1CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C21H22F2N2O2/c1-13-3-2-4-21(27)24(13)11-16(26)12-25-19-7-5-14(22)9-17(19)18-10-15(23)6-8-20(18)25/h5-10,13,16,26H,2-4,11-12H2,1H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356726
PNG
((1R,4S)-2-((S)-3- (9H-carbazol-9-yl)- 2-hydroxypro...)
Show SMILES O[C@H](CN1[C@@H]2CC[C@@H](C2)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C21H22N2O2/c24-16(12-22-15-10-9-14(11-15)21(22)25)13-23-19-7-3-1-5-17(19)18-6-2-4-8-20(18)23/h1-8,14-16,24H,9-13H2/t14-,15+,16+/m0/s1
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356728
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC1CCCC(=O)N1CC(C)(O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C22H24F2N2O2/c1-14-4-3-5-21(27)25(14)12-22(2,28)13-26-19-8-6-15(23)10-17(19)18-11-16(24)7-9-20(18)26/h6-11,14,28H,3-5,12-13H2,1-2H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356934
PNG
((S)-1-((R)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)...)
Show SMILES C[C@H]1CCN(C[C@H](O)Cn2c3ccccc3c3ccccc23)C1=O
Show InChI InChI=1S/C20H22N2O2/c1-14-10-11-21(20(14)24)12-15(23)13-22-18-8-4-2-6-16(18)17-7-3-5-9-19(17)22/h2-9,14-15,23H,10-13H2,1H3/t14-,15-/m0/s1
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356951
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES COC1CCCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C21H22F2N2O3/c1-28-20-3-2-8-24(21(20)27)11-15(26)12-25-18-6-4-13(22)9-16(18)17-10-14(23)5-7-19(17)25/h4-7,9-10,15,20,26H,2-3,8,11-12H2,1H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356979
PNG
((S)-1-((S)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)...)
Show SMILES C[C@H]1CCC(=O)N(C[C@@H](O)Cn2c3ccccc3c3ccccc23)C1
Show InChI InChI=1S/C21H24N2O2/c1-15-10-11-21(25)22(12-15)13-16(24)14-23-19-8-4-2-6-17(19)18-7-3-5-9-20(18)23/h2-9,15-16,24H,10-14H2,1H3/t15-,16+/m0/s1
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n/an/an/an/a 1.13E+3n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356639
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES OC(CN1CCNC1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C18H17F2N3O2/c19-11-1-3-16-14(7-11)15-8-12(20)2-4-17(15)23(16)10-13(24)9-22-6-5-21-18(22)25/h1-4,7-8,13,24H,5-6,9-10H2,(H,21,25)
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356644
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CN1CCCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C20H21F2N3O2/c1-23-7-2-8-24(20(23)27)11-15(26)12-25-18-5-3-13(21)9-16(18)17-10-14(22)4-6-19(17)25/h3-6,9-10,15,26H,2,7-8,11-12H2,1H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356649
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC(O)(CN1CCCC1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C20H20F2N2O2/c1-20(26,11-23-8-2-3-19(23)25)12-24-17-6-4-13(21)9-15(17)16-10-14(22)5-7-18(16)24/h4-7,9-10,26H,2-3,8,11-12H2,1H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356659
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC(C)N1CCCN(CC(C)(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C23H27F2N3O2/c1-15(2)27-10-4-9-26(22(27)29)13-23(3,30)14-28-20-7-5-16(24)11-18(20)19-12-17(25)6-8-21(19)28/h5-8,11-12,15,30H,4,9-10,13-14H2,1-3H3
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n/an/an/an/a 1.11E+3n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356663
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES OC(CN1CCCC(F)(F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C20H18F4N2O2/c21-12-2-4-17-15(8-12)16-9-13(22)3-5-18(16)26(17)11-14(27)10-25-7-1-6-20(23,24)19(25)28/h2-5,8-9,14,27H,1,6-7,10-11H2
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356671
PNG
(US10214507, Compound 85)
Show SMILES CC1CN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C(=O)N1
Show InChI InChI=1S/C19H19F2N3O2/c1-11-8-23(19(26)22-11)9-14(25)10-24-17-4-2-12(20)6-15(17)16-7-13(21)3-5-18(16)24/h2-7,11,14,25H,8-10H2,1H3,(H,22,26)
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n/an/an/an/a 667n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356679
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES OC(CN1CCCC(C1=O)c1ccccc1)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C26H24F2N2O2/c27-18-8-10-24-22(13-18)23-14-19(28)9-11-25(23)30(24)16-20(31)15-29-12-4-7-21(26(29)32)17-5-2-1-3-6-17/h1-3,5-6,8-11,13-14,20-21,31H,4,7,12,15-16H2
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356685
PNG
(3-cyclohexyl-1-(3- (3,6-difluoro-9H- carbazol-9-yl...)
Show SMILES CC(O)(CN1CCCC(C2CCCCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C27H32F2N2O2/c1-27(33,16-30-13-5-8-21(26(30)32)18-6-3-2-4-7-18)17-31-24-11-9-19(28)14-22(24)23-15-20(29)10-12-25(23)31/h9-12,14-15,18,21,33H,2-8,13,16-17H2,1H3
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n/an/an/an/a 1.04E+3n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356698
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC(C)C1CCCN(CC(C)(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C24H28F2N2O2/c1-15(2)18-5-4-10-27(23(18)29)13-24(3,30)14-28-21-8-6-16(25)11-19(21)20-12-17(26)7-9-22(20)28/h6-9,11-12,15,18,30H,4-5,10,13-14H2,1-3H3
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n/an/an/an/a 1.05E+3n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356704
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC1CCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C20H20F2N2O2/c1-12-6-7-23(20(12)26)10-15(25)11-24-18-4-2-13(21)8-16(18)17-9-14(22)3-5-19(17)24/h2-5,8-9,12,15,25H,6-7,10-11H2,1H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356705
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3- isop...)
Show SMILES CC(C)N1CCN(CC(O)Cn2c3ccccc3c3ccccc23)C1=O
Show InChI InChI=1S/C21H25N3O2/c1-15(2)23-12-11-22(21(23)26)13-16(25)14-24-19-9-5-3-7-17(19)18-8-4-6-10-20(18)24/h3-10,15-16,25H,11-14H2,1-2H3
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n/an/an/an/a 269n/an/an/an/a



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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356715
PNG
(3-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES OC(CN1Cc2ccccc2NC1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C23H19F2N3O2/c24-15-5-7-21-18(9-15)19-10-16(25)6-8-22(19)28(21)13-17(29)12-27-11-14-3-1-2-4-20(14)26-23(27)30/h1-10,17,29H,11-13H2,(H,26,30)
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356716
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC1CCC(=O)N1CC(C)(O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C21H22F2N2O2/c1-13-3-8-20(26)24(13)11-21(2,27)12-25-18-6-4-14(22)9-16(18)17-10-15(23)5-7-19(17)25/h4-7,9-10,13,27H,3,8,11-12H2,1-2H3
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n/an/an/an/a 678n/an/an/an/a



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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356717
PNG
(US10214507, Compound 104)
Show SMILES O[C@@H](CN1[C@H]2CC[C@H](C2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C21H20F2N2O2/c22-13-2-5-19-17(8-13)18-9-14(23)3-6-20(18)25(19)11-16(26)10-24-15-4-1-12(7-15)21(24)27/h2-3,5-6,8-9,12,15-16,26H,1,4,7,10-11H2/t12-,15+,16+/m1/s1
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n/an/an/an/a 115n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356924
PNG
((S)-1-((R)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)...)
Show SMILES C[C@H]1CCC(=O)N1C[C@H](O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C20H22N2O2/c1-14-10-11-20(24)21(14)12-15(23)13-22-18-8-4-2-6-16(18)17-7-3-5-9-19(17)22/h2-9,14-15,23H,10-13H2,1H3/t14-,15-/m0/s1
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n/an/an/an/a 470n/an/an/an/a



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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356937
PNG
(3-cyclobutyl-1-(3- (3,6-difluoro-9H- carbazol-9-yl...)
Show SMILES OC(CN1CCC(C2CCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C23H24F2N2O2/c24-15-4-6-21-19(10-15)20-11-16(25)5-7-22(20)27(21)13-17(28)12-26-9-8-18(23(26)29)14-2-1-3-14/h4-7,10-11,14,17-18,28H,1-3,8-9,12-13H2
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n/an/an/an/a 204n/an/an/an/a



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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356941
PNG
(3-cyclobutyl-1-(3- (3,6-difluoro-9H- carbazol-9-yl...)
Show SMILES CC(O)(CN1CCCC(C2CCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C25H28F2N2O2/c1-25(31,14-28-11-3-6-19(24(28)30)16-4-2-5-16)15-29-22-9-7-17(26)12-20(22)21-13-18(27)8-10-23(21)29/h7-10,12-13,16,19,31H,2-6,11,14-15H2,1H3
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n/an/an/an/a 1.36E+3n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356942
PNG
((R)-1-((R)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)...)
Show SMILES O[C@@H](CN1CC[C@@H](F)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C19H19FN2O2/c20-16-9-10-21(19(16)24)11-13(23)12-22-17-7-3-1-5-14(17)15-6-2-4-8-18(15)22/h1-8,13,16,23H,9-12H2/t13-,16+/m0/s1
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356956
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES OC(CN1CCC(F)(F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C19H16F4N2O2/c20-11-1-3-16-14(7-11)15-8-12(21)2-4-17(15)25(16)10-13(26)9-24-6-5-19(22,23)18(24)27/h1-4,7-8,13,26H,5-6,9-10H2
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356635
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3- meth...)
Show SMILES CN1CCCN(CC(O)Cn2c3ccccc3c3ccccc23)C1=O
Show InChI InChI=1S/C20H23N3O2/c1-21-11-6-12-22(20(21)25)13-15(24)14-23-18-9-4-2-7-16(18)17-8-3-5-10-19(17)23/h2-5,7-10,15,24H,6,11-14H2,1H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356642
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC(O)(CN1CCCCC1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C21H22F2N2O2/c1-21(27,12-24-9-3-2-4-20(24)26)13-25-18-7-5-14(22)10-16(18)17-11-15(23)6-8-19(17)25/h5-8,10-11,27H,2-4,9,12-13H2,1H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356653
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES OC(CN1CCC(F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C19H17F3N2O2/c20-11-1-3-17-14(7-11)15-8-12(21)2-4-18(15)24(17)10-13(25)9-23-6-5-16(22)19(23)26/h1-4,7-8,13,16,25H,5-6,9-10H2
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356654
PNG
(1-cyclobutyl-3-(3- (3,6-difluoro-9H- carbazol-9-yl...)
Show SMILES OC(CN1CCCN(C2CCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C23H25F2N3O2/c24-15-5-7-21-19(11-15)20-12-16(25)6-8-22(20)28(21)14-18(29)13-26-9-2-10-27(23(26)30)17-3-1-4-17/h5-8,11-12,17-18,29H,1-4,9-10,13-14H2
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n/an/an/an/a 440n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356670
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC1(C)CCCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C22H24F2N2O2/c1-22(2)8-3-9-25(21(22)28)12-16(27)13-26-19-6-4-14(23)10-17(19)18-11-15(24)5-7-20(18)26/h4-7,10-11,16,27H,3,8-9,12-13H2,1-2H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356672
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CCC1CCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C21H22F2N2O2/c1-2-13-7-8-24(21(13)27)11-16(26)12-25-19-5-3-14(22)9-17(19)18-10-15(23)4-6-20(18)25/h3-6,9-10,13,16,26H,2,7-8,11-12H2,1H3
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n/an/an/an/a 417n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356683
PNG
(3-cyclohexyl-1-(3- (3,6-difluoro-9H- carbazol-9-yl...)
Show SMILES OC(CN1CCCC(C2CCCCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C26H30F2N2O2/c27-18-8-10-24-22(13-18)23-14-19(28)9-11-25(23)30(24)16-20(31)15-29-12-4-7-21(26(29)32)17-5-2-1-3-6-17/h8-11,13-14,17,20-21,31H,1-7,12,15-16H2
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356694
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CCC1CCCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C22H24F2N2O2/c1-2-14-4-3-9-25(22(14)28)12-17(27)13-26-20-7-5-15(23)10-18(20)19-11-16(24)6-8-21(19)26/h5-8,10-11,14,17,27H,2-4,9,12-13H2,1H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356702
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC1CCCN(CC(C)(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C22H24F2N2O2/c1-14-4-3-9-25(21(14)27)12-22(2,28)13-26-19-7-5-15(23)10-17(19)18-11-16(24)6-8-20(18)26/h5-8,10-11,14,28H,3-4,9,12-13H2,1-2H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356720
PNG
((1R,4S)-2-((R)-3- (3,6-difluoro-9H- carbazol-9-yl)...)
Show SMILES O[C@@H](CN1[C@@H]2CC[C@@H](C2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C21H20F2N2O2/c22-13-2-5-19-17(8-13)18-9-14(23)3-6-20(18)25(19)11-16(26)10-24-15-4-1-12(7-15)21(24)27/h2-3,5-6,8-9,12,15-16,26H,1,4,7,10-11H2/t12-,15+,16-/m0/s1
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356724
PNG
((1R,4S)-2-((R)-3- (9H-carbazol-9-yl)- 2-hydroxypro...)
Show SMILES O[C@@H](CN1[C@@H]2CC[C@@H](C2)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C21H22N2O2/c24-16(12-22-15-10-9-14(11-15)21(22)25)13-23-19-7-3-1-5-17(19)18-6-2-4-8-20(18)23/h1-8,14-16,24H,9-13H2/t14-,15+,16-/m0/s1
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n/an/an/an/a 89n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356922
PNG
((R)-1-((R)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)...)
Show SMILES C[C@@H]1CCC(=O)N1C[C@H](O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C20H22N2O2/c1-14-10-11-20(24)21(14)12-15(23)13-22-18-8-4-2-6-16(18)17-7-3-5-9-19(17)22/h2-9,14-15,23H,10-13H2,1H3/t14-,15+/m1/s1
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n/an/an/an/a 95n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356923
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC1CN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C(=O)C1
Show InChI InChI=1S/C20H20F2N2O2/c1-12-6-20(26)23(9-12)10-15(25)11-24-18-4-2-13(21)7-16(18)17-8-14(22)3-5-19(17)24/h2-5,7-8,12,15,25H,6,9-11H2,1H3
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n/an/an/an/a 1.03E+3n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356925
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC1CN(CC(C)(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C(=O)C1
Show InChI InChI=1S/C21H22F2N2O2/c1-13-7-20(26)24(10-13)11-21(2,27)12-25-18-5-3-14(22)8-16(18)17-9-15(23)4-6-19(17)25/h3-6,8-9,13,27H,7,10-12H2,1-2H3
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n/an/an/an/a 1.06E+3n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356936
PNG
((R)-1-((R)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)...)
Show SMILES C[C@@H]1CCN(C[C@H](O)Cn2c3ccccc3c3ccccc23)C1=O
Show InChI InChI=1S/C20H22N2O2/c1-14-10-11-21(20(14)24)12-15(23)13-22-18-8-4-2-6-16(18)17-7-3-5-9-19(17)22/h2-9,14-15,23H,10-13H2,1H3/t14-,15+/m1/s1
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n/an/an/an/a 120n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356944
PNG
((S)-1-((R)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)...)
Show SMILES O[C@@H](CN1CC[C@H](F)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C19H19FN2O2/c20-16-9-10-21(19(16)24)11-13(23)12-22-17-7-3-1-5-14(17)15-6-2-4-8-18(15)22/h1-8,13,16,23H,9-12H2/t13-,16-/m0/s1
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n/an/an/an/a 263n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356945
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC(O)(CN1CCC(C1=O)c1ccccc1)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C26H24F2N2O2/c1-26(32,15-29-12-11-20(25(29)31)17-5-3-2-4-6-17)16-30-23-9-7-18(27)13-21(23)22-14-19(28)8-10-24(22)30/h2-10,13-14,20,32H,11-12,15-16H2,1H3
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n/an/an/an/a 808n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356946
PNG
((R)-1-((S)-3-(9H- carbazol-9-yl)-2- hydroxy-2- met...)
Show SMILES C[C@@](O)(CN1CC[C@@H](F)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C20H21FN2O2/c1-20(25,12-22-11-10-16(21)19(22)24)13-23-17-8-4-2-6-14(17)15-7-3-5-9-18(15)23/h2-9,16,25H,10-13H2,1H3/t16-,20-/m1/s1
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n/an/an/an/a 311n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356973
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-5- meth...)
Show SMILES CC1CCC(=O)N(CC(O)Cn2c3ccccc3c3ccccc23)C1
Show InChI InChI=1S/C21H24N2O2/c1-15-10-11-21(25)22(12-15)13-16(24)14-23-19-8-4-2-6-17(19)18-7-3-5-9-20(18)23/h2-9,15-16,24H,10-14H2,1H3
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n/an/an/an/a 370n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356988
PNG
((R)-1-((R)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- ...)
Show SMILES C[C@@H]1CN(C[C@H](O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C(=O)N1
Show InChI InChI=1S/C19H19F2N3O2/c1-11-8-23(19(26)22-11)9-14(25)10-24-17-4-2-12(20)6-15(17)16-7-13(21)3-5-18(16)24/h2-7,11,14,25H,8-10H2,1H3,(H,22,26)/t11-,14+/m1/s1
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n/an/an/an/a 826n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356992
PNG
((S)-1-((R)-3-(9H- carbaxol-9-yl)-2- hydroxypropyl)...)
Show SMILES C[C@H]1CN(C[C@H](O)Cn2c3ccccc3c3ccccc23)C(=O)N1
Show InChI InChI=1S/C19H21N3O2/c1-13-10-21(19(24)20-13)11-14(23)12-22-17-8-4-2-6-15(17)16-7-3-5-9-18(16)22/h2-9,13-14,23H,10-12H2,1H3,(H,20,24)/t13-,14-/m0/s1
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n/an/an/an/a 520n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356643
PNG
(1-cyclohexyl-3-(3- (3,6-difluoro-9H- carbazol-9-yl...)
Show SMILES OC(CN1CCCN(C2CCCCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C25H29F2N3O2/c26-17-7-9-23-21(13-17)22-14-18(27)8-10-24(22)30(23)16-20(31)15-28-11-4-12-29(25(28)32)19-5-2-1-3-6-19/h7-10,13-14,19-20,31H,1-6,11-12,15-16H2
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n/an/an/an/a 284n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356648
PNG
(1-cyclopentyl-3-(3- (3,6-difluoro-9H- carbazol-9-y...)
Show SMILES OC(CN1CCCN(C2CCCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C24H27F2N3O2/c25-16-6-8-22-20(12-16)21-13-17(26)7-9-23(21)29(22)15-19(30)14-27-10-3-11-28(24(27)31)18-4-1-2-5-18/h6-9,12-13,18-19,30H,1-5,10-11,14-15H2
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n/an/an/an/a 609n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356656
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC(O)(CN1CCCN(C1=O)c1ccccc1)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C26H25F2N3O2/c1-26(33,16-29-12-5-13-30(25(29)32)20-6-3-2-4-7-20)17-31-23-10-8-18(27)14-21(23)22-15-19(28)9-11-24(22)31/h2-4,6-11,14-15,33H,5,12-13,16-17H2,1H3
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n/an/an/an/a 923n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356665
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC(O)(CN1CCCC(F)(F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C21H20F4N2O2/c1-20(29,11-26-8-2-7-21(24,25)19(26)28)12-27-17-5-3-13(22)9-15(17)16-10-14(23)4-6-18(16)27/h3-6,9-10,29H,2,7-8,11-12H2,1H3
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n/an/an/an/a 541n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356684
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES OC(CN1CCN(C1=O)c1ccccc1)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C24H21F2N3O2/c25-16-6-8-22-20(12-16)21-13-17(26)7-9-23(21)29(22)15-19(30)14-27-10-11-28(24(27)31)18-4-2-1-3-5-18/h1-9,12-13,19,30H,10-11,14-15H2
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n/an/an/an/a 438n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356693
PNG
(1-cyclopropyl-3-(3- (3,6-difluoro-9H- carbazol-9-y...)
Show SMILES OC(CN1CCN(C2CC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C21H21F2N3O2/c22-13-1-5-19-17(9-13)18-10-14(23)2-6-20(18)26(19)12-16(27)11-24-7-8-25(21(24)28)15-3-4-15/h1-2,5-6,9-10,15-16,27H,3-4,7-8,11-12H2
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n/an/an/an/a 527n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356710
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CCC1CCC(=O)N1CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C21H22F2N2O2/c1-2-15-5-8-21(27)24(15)11-16(26)12-25-19-6-3-13(22)9-17(19)18-10-14(23)4-7-20(18)25/h3-4,6-7,9-10,15-16,26H,2,5,8,11-12H2,1H3
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n/an/an/an/a 539n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356721
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC1CCC(=O)N(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1
Show InChI InChI=1S/C21H22F2N2O2/c1-13-2-7-21(27)24(10-13)11-16(26)12-25-19-5-3-14(22)8-17(19)18-9-15(23)4-6-20(18)25/h3-6,8-9,13,16,26H,2,7,10-12H2,1H3
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n/an/an/an/a 224n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356921
PNG
(4-cyclopropyl-1-(3- (3,6-difluoro-9H- carbazol-9-y...)
Show SMILES OC(CN1CC(CC1=O)C1CC1)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C22H22F2N2O2/c23-15-3-5-20-18(8-15)19-9-16(24)4-6-21(19)26(20)12-17(27)11-25-10-14(7-22(25)28)13-1-2-13/h3-6,8-9,13-14,17,27H,1-2,7,10-12H2
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n/an/an/an/a 420n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356932
PNG
((R)-1-((R)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- ...)
Show SMILES C[C@@H]1CCN(C[C@H](O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C20H20F2N2O2/c1-12-6-7-23(20(12)26)10-15(25)11-24-18-4-2-13(21)8-16(18)17-9-14(22)3-5-19(17)24/h2-5,8-9,12,15,25H,6-7,10-11H2,1H3/t12-,15+/m1/s1
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n/an/an/an/a 311n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356962
PNG
((S)-1-((R)-3-(9H- carbazol-9-yl)-2- hydroxy-2- met...)
Show SMILES CC(O)(CN1CC[C@H](F)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C20H21FN2O2/c1-20(25,12-22-11-10-16(21)19(22)24)13-23-17-8-4-2-6-14(17)15-7-3-5-9-18(15)23/h2-9,16,25H,10-13H2,1H3/t16-,20?/m0/s1
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n/an/an/an/a 172n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356980
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3- meth...)
Show SMILES CC1CCCN(CC(O)Cn2c3ccccc3c3ccccc23)C1=O
Show InChI InChI=1S/C21H24N2O2/c1-15-7-6-12-22(21(15)25)13-16(24)14-23-19-10-4-2-8-17(19)18-9-3-5-11-20(18)23/h2-5,8-11,15-16,24H,6-7,12-14H2,1H3
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n/an/an/an/a 462n/an/an/an/a



Reset Therapeutics, Inc.

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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356986
PNG
((S)-1-((R)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- ...)
Show SMILES C[C@H]1CN(C[C@H](O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C(=O)N1
Show InChI InChI=1S/C19H19F2N3O2/c1-11-8-23(19(26)22-11)9-14(25)10-24-17-4-2-12(20)6-15(17)16-7-13(21)3-5-18(16)24/h2-7,11,14,25H,8-10H2,1H3,(H,22,26)/t11-,14-/m0/s1
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356993
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3,3- di...)
Show SMILES OC(CN1CCCC(F)(F)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C20H20F2N2O2/c21-20(22)10-5-11-23(19(20)26)12-14(25)13-24-17-8-3-1-6-15(17)16-7-2-4-9-18(16)24/h1-4,6-9,14,25H,5,10-13H2
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356640
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES OC(CN1CCCCC1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C20H20F2N2O2/c21-13-4-6-18-16(9-13)17-10-14(22)5-7-19(17)24(18)12-15(25)11-23-8-2-1-3-20(23)26/h4-7,9-10,15,25H,1-3,8,11-12H2
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356650
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC(C)N1CCCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C22H25F2N3O2/c1-14(2)26-9-3-8-25(22(26)29)12-17(28)13-27-20-6-4-15(23)10-18(20)19-11-16(24)5-7-21(19)27/h4-7,10-11,14,17,28H,3,8-9,12-13H2,1-2H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356668
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC1(C)CCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C21H22F2N2O2/c1-21(2)7-8-24(20(21)27)11-15(26)12-25-18-5-3-13(22)9-16(18)17-10-14(23)4-6-19(17)25/h3-6,9-10,15,26H,7-8,11-12H2,1-2H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356687
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC(C)C1CCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C22H24F2N2O2/c1-13(2)17-7-8-25(22(17)28)11-16(27)12-26-20-5-3-14(23)9-18(20)19-10-15(24)4-6-21(19)26/h3-6,9-10,13,16-17,27H,7-8,11-12H2,1-2H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356714
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC1CCC(=O)N1CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C20H20F2N2O2/c1-12-2-7-20(26)23(12)10-15(25)11-24-18-5-3-13(21)8-16(18)17-9-14(22)4-6-19(17)24/h3-6,8-9,12,15,25H,2,7,10-11H2,1H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356930
PNG
((S)-1-((R)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- ...)
Show SMILES C[C@H]1CCN(C[C@H](O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C20H20F2N2O2/c1-12-6-7-23(20(12)26)10-15(25)11-24-18-4-2-13(21)8-16(18)17-9-14(22)3-5-19(17)24/h2-5,8-9,12,15,25H,6-7,10-11H2,1H3/t12-,15-/m0/s1
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356940
PNG
((S)-1-((R)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- ...)
Show SMILES O[C@@H](CN1CC[C@H](F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C19H17F3N2O2/c20-11-1-3-17-14(7-11)15-8-12(21)2-4-18(15)24(17)10-13(25)9-23-6-5-16(22)19(23)26/h1-4,7-8,13,16,25H,5-6,9-10H2/t13-,16-/m0/s1
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356947
PNG
(4-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES OC(CN1CCOCC1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C19H18F2N2O3/c20-12-1-3-17-15(7-12)16-8-13(21)2-4-18(16)23(17)10-14(24)9-22-5-6-26-11-19(22)25/h1-4,7-8,14,24H,5-6,9-11H2
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356958
PNG
((R)-1-((R)-3-(9H- carbazol-9-yl)-2- hydroxy-2- met...)
Show SMILES CC(O)(CN1CC[C@@H](F)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C20H21FN2O2/c1-20(25,12-22-11-10-16(21)19(22)24)13-23-17-8-4-2-6-14(17)15-7-3-5-9-18(15)23/h2-9,16,25H,10-13H2,1H3/t16-,20?/m1/s1
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356992
PNG
((S)-1-((R)-3-(9H- carbaxol-9-yl)-2- hydroxypropyl)...)
Show SMILES C[C@H]1CN(C[C@H](O)Cn2c3ccccc3c3ccccc23)C(=O)N1
Show InChI InChI=1S/C19H21N3O2/c1-13-10-21(19(24)20-13)11-14(23)12-22-17-8-4-2-6-15(17)16-7-3-5-9-18(16)22/h2-9,13-14,23H,10-12H2,1H3,(H,20,24)/t13-,14-/m0/s1
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356660
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC(O)(CN1CCCC(F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C21H21F3N2O2/c1-21(28,11-25-8-2-3-17(24)20(25)27)12-26-18-6-4-13(22)9-15(18)16-10-14(23)5-7-19(16)26/h4-7,9-10,17,28H,2-3,8,11-12H2,1H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356675
PNG
(3-cyclopentyl-1-(3- (3,6-difluoro-9H- carbazol-9-y...)
Show SMILES OC(CN1CCC(C2CCCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C24H26F2N2O2/c25-16-5-7-22-20(11-16)21-12-17(26)6-8-23(21)28(22)14-18(29)13-27-10-9-19(24(27)30)15-3-1-2-4-15/h5-8,11-12,15,18-19,29H,1-4,9-10,13-14H2
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356680
PNG
(1-cyclohexyl-3-(3- (3,6-difluoro-9H- carbazol-9-yl...)
Show SMILES OC(CN1CCN(C2CCCCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C24H27F2N3O2/c25-16-6-8-22-20(12-16)21-13-17(26)7-9-23(21)29(22)15-19(30)14-27-10-11-28(24(27)31)18-4-2-1-3-5-18/h6-9,12-13,18-19,30H,1-5,10-11,14-15H2
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356686
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC(C)N1CCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C21H23F2N3O2/c1-13(2)25-8-7-24(21(25)28)11-16(27)12-26-19-5-3-14(22)9-17(19)18-10-15(23)4-6-20(18)26/h3-6,9-10,13,16,27H,7-8,11-12H2,1-2H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356695
PNG
(1-cyclobutyl-3-(3- (3,6-difluoro-9H- carbazol-9-yl...)
Show SMILES OC(CN1CCN(C2CCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C22H23F2N3O2/c23-14-4-6-20-18(10-14)19-11-15(24)5-7-21(19)27(20)13-17(28)12-25-8-9-26(22(25)29)16-2-1-3-16/h4-7,10-11,16-17,28H,1-3,8-9,12-13H2
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356700
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC1CCCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C21H22F2N2O2/c1-13-3-2-8-24(21(13)27)11-16(26)12-25-19-6-4-14(22)9-17(19)18-10-15(23)5-7-20(18)25/h4-7,9-10,13,16,26H,2-3,8,11-12H2,1H3
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Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356706
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC1CCN(CC(C)(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C21H22F2N2O2/c1-13-7-8-24(20(13)26)11-21(2,27)12-25-18-5-3-14(22)9-16(18)17-10-15(23)4-6-19(17)25/h3-6,9-10,13,27H,7-8,11-12H2,1-2H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356707
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3- cycl...)
Show SMILES OC(CN1CCCN(C2CC2)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C22H25N3O2/c26-17(14-23-12-5-13-24(22(23)27)16-10-11-16)15-25-20-8-3-1-6-18(20)19-7-2-4-9-21(19)25/h1-4,6-9,16-17,26H,5,10-15H2
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356708
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC1(C)CN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C(=O)C1
Show InChI InChI=1S/C21H22F2N2O2/c1-21(2)9-20(27)24(12-21)10-15(26)11-25-18-5-3-13(22)7-16(18)17-8-14(23)4-6-19(17)25/h3-8,15,26H,9-12H2,1-2H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356709
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3- cycl...)
Show SMILES OC(CN1CCCN(C2CCC2)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C23H27N3O2/c27-18(15-24-13-6-14-25(23(24)28)17-7-5-8-17)16-26-21-11-3-1-9-19(21)20-10-2-4-12-22(20)26/h1-4,9-12,17-18,27H,5-8,13-16H2
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356722
PNG
((1S,4R)-2-((R)-3- (9H-carbazol-9-yl)- 2-hydroxypro...)
Show SMILES O[C@@H](CN1[C@H]2CC[C@H](C2)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C21H22N2O2/c24-16(12-22-15-10-9-14(11-15)21(22)25)13-23-19-7-3-1-5-17(19)18-6-2-4-8-20(18)23/h1-8,14-16,24H,9-13H2/t14-,15+,16+/m1/s1
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356729
PNG
((R)-1-((R)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- ...)
Show SMILES C[C@@H]1CCC(=O)N1C[C@H](O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C20H20F2N2O2/c1-12-2-7-20(26)23(12)10-15(25)11-24-18-5-3-13(21)8-16(18)17-9-14(22)4-6-19(17)24/h3-6,8-9,12,15,25H,2,7,10-11H2,1H3/t12-,15+/m1/s1
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356926
PNG
((R)-1-((S)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)...)
Show SMILES C[C@@H]1CCC(=O)N1C[C@@H](O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C20H22N2O2/c1-14-10-11-20(24)21(14)12-15(23)13-22-18-8-4-2-6-16(18)17-7-3-5-9-19(17)22/h2-9,14-15,23H,10-13H2,1H3/t14-,15-/m1/s1
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n/an/an/an/a 948n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356928
PNG
((R)-1-(3-(3,6- difluoro-9H- carbazol-9-yl)-2- hydr...)
Show SMILES O[C@@H](CN1CCNC1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C18H17F2N3O2/c19-11-1-3-16-14(7-11)15-8-12(20)2-4-17(15)23(16)10-13(24)9-22-6-5-21-18(22)25/h1-4,7-8,13,24H,5-6,9-10H2,(H,21,25)/t13-/m0/s1
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356931
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC1CC(=O)N(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1C
Show InChI InChI=1S/C21H22F2N2O2/c1-12-7-21(27)24(13(12)2)10-16(26)11-25-19-5-3-14(22)8-17(19)18-9-15(23)4-6-20(18)25/h3-6,8-9,12-13,16,26H,7,10-11H2,1-2H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356933
PNG
(2-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES OC(CN1C2CCC(C2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C21H20F2N2O2/c22-13-2-5-19-17(8-13)18-9-14(23)3-6-20(18)25(19)11-16(26)10-24-15-4-1-12(7-15)21(24)27/h2-3,5-6,8-9,12,15-16,26H,1,4,7,10-11H2
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356935
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC1CCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C(=O)C1
Show InChI InChI=1S/C21H22F2N2O2/c1-13-6-7-24(21(27)8-13)11-16(26)12-25-19-4-2-14(22)9-17(19)18-10-15(23)3-5-20(18)25/h2-5,9-10,13,16,26H,6-8,11-12H2,1H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356939
PNG
(3-cyclobutyl-1-(3- (3,6-difluoro-9H- carbazol-9-yl...)
Show SMILES OC(CN1CCCC(C2CCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C24H26F2N2O2/c25-16-6-8-22-20(11-16)21-12-17(26)7-9-23(21)28(22)14-18(29)13-27-10-2-5-19(24(27)30)15-3-1-4-15/h6-9,11-12,15,18-19,29H,1-5,10,13-14H2
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356950
PNG
((S)-1-((S)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- ...)
Show SMILES CC(O)(CN1CC[C@H](F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C20H19F3N2O2/c1-20(27,10-24-7-6-16(23)19(24)26)11-25-17-4-2-12(21)8-14(17)15-9-13(22)3-5-18(15)25/h2-5,8-9,16,27H,6-7,10-11H2,1H3/t16-,20?/m0/s1
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356982
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-4- cycl...)
Show SMILES OC(CN1CC(CC1=O)C1CC1)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C22H24N2O2/c25-17(13-23-12-16(11-22(23)26)15-9-10-15)14-24-20-7-3-1-5-18(20)19-6-2-4-8-21(19)24/h1-8,15-17,25H,9-14H2
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n/an/an/an/a 1.03E+3n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356987
PNG
(1-(3-(9H-carbazol- 9-yl)-2-hydroxy-2- methylpropyl...)
Show SMILES CC(O)(CN1CCCC1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C20H22N2O2/c1-20(24,13-21-12-6-11-19(21)23)14-22-17-9-4-2-7-15(17)16-8-3-5-10-18(16)22/h2-5,7-10,24H,6,11-14H2,1H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356634
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3- fluo...)
Show SMILES OC(CN1CCCC(F)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C20H21FN2O2/c21-17-8-5-11-22(20(17)25)12-14(24)13-23-18-9-3-1-6-15(18)16-7-2-4-10-19(16)23/h1-4,6-7,9-10,14,17,24H,5,8,11-13H2
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356655
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC(O)(CN1CCC(F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C20H19F3N2O2/c1-20(27,10-24-7-6-16(23)19(24)26)11-25-17-4-2-12(21)8-14(17)15-9-13(22)3-5-18(15)25/h2-5,8-9,16,27H,6-7,10-11H2,1H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356664
PNG
(1-cyclohexyl-3-(3- (3,6-difluoro-9H- carbazol-9-yl...)
Show SMILES CC(O)(CN1CCCN(C2CCCCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C26H31F2N3O2/c1-26(33,16-29-12-5-13-30(25(29)32)20-6-3-2-4-7-20)17-31-23-10-8-18(27)14-21(23)22-15-19(28)9-11-24(22)31/h8-11,14-15,20,33H,2-7,12-13,16-17H2,1H3
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n/an/an/an/a 1.19E+3n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356666
PNG
(1-cyclopropyl-3-(3- (3,6-difluoro-9H- carbazol-9-y...)
Show SMILES OC(CN1CCCN(C2CC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C22H23F2N3O2/c23-14-2-6-20-18(10-14)19-11-15(24)3-7-21(19)27(20)13-17(28)12-25-8-1-9-26(22(25)29)16-4-5-16/h2-3,6-7,10-11,16-17,28H,1,4-5,8-9,12-13H2
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356674
PNG
(US10214507, Compound 86)
Show SMILES CCN1CCCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C21H23F2N3O2/c1-2-24-8-3-9-25(21(24)28)12-16(27)13-26-19-6-4-14(22)10-17(19)18-11-15(23)5-7-20(18)26/h4-7,10-11,16,27H,2-3,8-9,12-13H2,1H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356691
PNG
(3-cyclopentyl-1-(3- (3,6-difluoro-9H- carbazol-9-y...)
Show SMILES OC(CN1CCCC(C2CCCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C25H28F2N2O2/c26-17-7-9-23-21(12-17)22-13-18(27)8-10-24(22)29(23)15-19(30)14-28-11-3-6-20(25(28)31)16-4-1-2-5-16/h7-10,12-13,16,19-20,30H,1-6,11,14-15H2
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356696
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC(C)C1CCCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C23H26F2N2O2/c1-14(2)18-4-3-9-26(23(18)29)12-17(28)13-27-21-7-5-15(24)10-19(21)20-11-16(25)6-8-22(20)27/h5-8,10-11,14,17-18,28H,3-4,9,12-13H2,1-2H3
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356701
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3- cycl...)
Show SMILES OC(CN1CCN(C2CCC2)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C22H25N3O2/c26-17(14-23-12-13-24(22(23)27)16-6-5-7-16)15-25-20-10-3-1-8-18(20)19-9-2-4-11-21(19)25/h1-4,8-11,16-17,26H,5-7,12-15H2
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356703
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3- cycl...)
Show SMILES OC(CN1CCN(C2CC2)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C21H23N3O2/c25-16(13-22-11-12-23(21(22)26)15-9-10-15)14-24-19-7-3-1-5-17(19)18-6-2-4-8-20(18)24/h1-8,15-16,25H,9-14H2
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356713
PNG
(US10214507, Compound 102)
Show SMILES CC(O)(CN1Cc2ccccc2NC1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C24H21F2N3O2/c1-24(31,13-28-12-15-4-2-3-5-20(15)27-23(28)30)14-29-21-8-6-16(25)10-18(21)19-11-17(26)7-9-22(19)29/h2-11,31H,12-14H2,1H3,(H,27,30)
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356938
PNG
((R)-1-((R)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- ...)
Show SMILES O[C@@H](CN1CC[C@@H](F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C19H17F3N2O2/c20-11-1-3-17-14(7-11)15-8-12(21)2-4-18(15)24(17)10-13(25)9-23-6-5-16(22)19(23)26/h1-4,7-8,13,16,25H,5-6,9-10H2/t13-,16+/m0/s1
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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356943
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES OC(CN1CCC(C1=O)c1ccccc1)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C25H22F2N2O2/c26-17-6-8-23-21(12-17)22-13-18(27)7-9-24(22)29(23)15-19(30)14-28-11-10-20(25(28)31)16-4-2-1-3-5-16/h1-9,12-13,19-20,30H,10-11,14-15H2
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n/an/an/an/a 1.34E+3n/an/an/an/a



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Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356952
PNG
((R)-1-((S)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- ...)
Show SMILES CC(O)(CN1CC[C@@H](F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C20H19F3N2O2/c1-20(27,10-24-7-6-16(23)19(24)26)11-25-17-4-2-12(21)8-14(17)15-9-13(22)3-5-18(15)25/h2-5,8-9,16,27H,6-7,10-11H2,1H3/t16-,20?/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 958n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356961
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2...)
Show SMILES CC(O)(CN1CCC(F)(F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C20H18F4N2O2/c1-19(28,10-25-7-6-20(23,24)18(25)27)11-26-16-4-2-12(21)8-14(16)15-9-13(22)3-5-17(15)26/h2-5,8-9,28H,6-7,10-11H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 986n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356969
PNG
(2-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-4- meth...)
Show SMILES CC1CCN(CC(O)Cn2c3ccccc3c3ccccc23)C(=O)C1
Show InChI InChI=1S/C21H24N2O2/c1-15-10-11-22(21(25)12-15)13-16(24)14-23-19-8-4-2-6-17(19)18-7-3-5-9-20(18)23/h2-9,15-16,24H,10-14H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 710n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%