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Patent code US10214515

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357253
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES CCn1cc(cn1)-c1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C27H24N8O/c1-2-34-14-18(12-29-34)16-5-6-17-10-24(31-22(17)9-16)25(36)20-13-30-35(26(20)28)19-7-8-21-23(11-19)33-27(32-21)15-3-4-15/h5-15,31H,2-4,28H2,1H3,(H,32,33)
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n/an/a 0.700n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357251
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccc(Br)cc2[nH]1
Show InChI InChI=1S/C22H17BrN6O/c23-13-4-3-12-7-19(26-17(12)8-13)20(30)15-10-25-29(21(15)24)14-5-6-16-18(9-14)28-22(27-16)11-1-2-11/h3-11,26H,1-2,24H2,(H,27,28)
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n/an/a 2.60n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357252
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Cn1cc(cn1)-c1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C26H22N8O/c1-33-13-17(11-28-33)15-4-5-16-9-23(30-21(16)8-15)24(35)19-12-29-34(25(19)27)18-6-7-20-22(10-18)32-26(31-20)14-2-3-14/h4-14,30H,2-3,27H2,1H3,(H,31,32)
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n/an/a 2.70n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357253
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES CCn1cc(cn1)-c1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C27H24N8O/c1-2-34-14-18(12-29-34)16-5-6-17-10-24(31-22(17)9-16)25(36)20-13-30-35(26(20)28)19-7-8-21-23(11-19)33-27(32-21)15-3-4-15/h5-15,31H,2-4,28H2,1H3,(H,32,33)
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n/an/a 4.90n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357250
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccc(F)cc2[nH]1
Show InChI InChI=1S/C22H17FN6O/c23-13-4-3-12-7-19(26-17(12)8-13)20(30)15-10-25-29(21(15)24)14-5-6-16-18(9-14)28-22(27-16)11-1-2-11/h3-11,26H,1-2,24H2,(H,27,28)
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n/an/a 5n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357251
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccc(Br)cc2[nH]1
Show InChI InChI=1S/C22H17BrN6O/c23-13-4-3-12-7-19(26-17(12)8-13)20(30)15-10-25-29(21(15)24)14-5-6-16-18(9-14)28-22(27-16)11-1-2-11/h3-11,26H,1-2,24H2,(H,27,28)
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n/an/a 5n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357254
PNG
(2-(5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccc(cc2[nH]1)C#N
Show InChI InChI=1S/C23H17N7O/c24-10-12-1-2-14-8-20(27-18(14)7-12)21(31)16-11-26-30(22(16)25)15-5-6-17-19(9-15)29-23(28-17)13-3-4-13/h1-2,5-9,11,13,27H,3-4,25H2,(H,28,29)
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357246
PNG
((5-amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C22H18N6O/c23-21-15(20(29)19-9-13-3-1-2-4-16(13)25-19)11-24-28(21)14-7-8-17-18(10-14)27-22(26-17)12-5-6-12/h1-4,7-12,25H,5-6,23H2,(H,26,27)
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n/an/a 6.20n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357253
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES CCn1cc(cn1)-c1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C27H24N8O/c1-2-34-14-18(12-29-34)16-5-6-17-10-24(31-22(17)9-16)25(36)20-13-30-35(26(20)28)19-7-8-21-23(11-19)33-27(32-21)15-3-4-15/h5-15,31H,2-4,28H2,1H3,(H,32,33)
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n/an/a 6.80n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357254
PNG
(2-(5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccc(cc2[nH]1)C#N
Show InChI InChI=1S/C23H17N7O/c24-10-12-1-2-14-8-20(27-18(14)7-12)21(31)16-11-26-30(22(16)25)15-5-6-17-19(9-15)29-23(28-17)13-3-4-13/h1-2,5-9,11,13,27H,3-4,25H2,(H,28,29)
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n/an/a 8.60n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357254
PNG
(2-(5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccc(cc2[nH]1)C#N
Show InChI InChI=1S/C23H17N7O/c24-10-12-1-2-14-8-20(27-18(14)7-12)21(31)16-11-26-30(22(16)25)15-5-6-17-19(9-15)29-23(28-17)13-3-4-13/h1-2,5-9,11,13,27H,3-4,25H2,(H,28,29)
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n/an/a 9.10n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357249
PNG
((5-amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C22H17FN6O/c23-13-3-5-16-12(7-13)8-19(26-16)20(30)15-10-25-29(21(15)24)14-4-6-17-18(9-14)28-22(27-17)11-1-2-11/h3-11,26H,1-2,24H2,(H,27,28)
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n/an/a 10n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357252
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Cn1cc(cn1)-c1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C26H22N8O/c1-33-13-17(11-28-33)15-4-5-16-9-23(30-21(16)8-15)24(35)19-12-29-34(25(19)27)18-6-7-20-22(10-18)32-26(31-20)14-2-3-14/h4-14,30H,2-3,27H2,1H3,(H,31,32)
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n/an/a 14n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357246
PNG
((5-amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C22H18N6O/c23-21-15(20(29)19-9-13-3-1-2-4-16(13)25-19)11-24-28(21)14-7-8-17-18(10-14)27-22(26-17)12-5-6-12/h1-4,7-12,25H,5-6,23H2,(H,26,27)
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n/an/a 15.1n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357250
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccc(F)cc2[nH]1
Show InChI InChI=1S/C22H17FN6O/c23-13-4-3-12-7-19(26-17(12)8-13)20(30)15-10-25-29(21(15)24)14-5-6-16-18(9-14)28-22(27-16)11-1-2-11/h3-11,26H,1-2,24H2,(H,27,28)
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n/an/a 18n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357250
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccc(F)cc2[nH]1
Show InChI InChI=1S/C22H17FN6O/c23-13-4-3-12-7-19(26-17(12)8-13)20(30)15-10-25-29(21(15)24)14-5-6-16-18(9-14)28-22(27-16)11-1-2-11/h3-11,26H,1-2,24H2,(H,27,28)
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n/an/a 19n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357249
PNG
((5-amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C22H17FN6O/c23-13-3-5-16-12(7-13)8-19(26-16)20(30)15-10-25-29(21(15)24)14-4-6-17-18(9-14)28-22(27-17)11-1-2-11/h3-11,26H,1-2,24H2,(H,27,28)
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n/an/a 21n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357246
PNG
((5-amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C22H18N6O/c23-21-15(20(29)19-9-13-3-1-2-4-16(13)25-19)11-24-28(21)14-7-8-17-18(10-14)27-22(26-17)12-5-6-12/h1-4,7-12,25H,5-6,23H2,(H,26,27)
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n/an/a 22n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357249
PNG
((5-amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C22H17FN6O/c23-13-3-5-16-12(7-13)8-19(26-16)20(30)15-10-25-29(21(15)24)14-4-6-17-18(9-14)28-22(27-17)11-1-2-11/h3-11,26H,1-2,24H2,(H,27,28)
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n/an/a 26n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357247
PNG
(Methyl 5-(5-amino-4-(1H-indole-2-carbonyl)-1H-pyra...)
Show SMILES COC(=O)c1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C21H16N6O3/c1-30-21(29)20-25-15-7-6-12(9-16(15)26-20)27-19(22)13(10-23-27)18(28)17-8-11-4-2-3-5-14(11)24-17/h2-10,24H,22H2,1H3,(H,25,26)
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n/an/a 30n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357248
PNG
(Ethyl 5-(5-Amino-4-(1H-indole-2-carbonyl)-1H-pyraz...)
Show SMILES CCOC(=O)c1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C22H18N6O3/c1-2-31-22(30)21-26-16-8-7-13(10-17(16)27-21)28-20(23)14(11-24-28)19(29)18-9-12-5-3-4-6-15(12)25-18/h3-11,25H,2,23H2,1H3,(H,26,27)
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n/an/a 44n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357252
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Cn1cc(cn1)-c1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C26H22N8O/c1-33-13-17(11-28-33)15-4-5-16-9-23(30-21(16)8-15)24(35)19-12-29-34(25(19)27)18-6-7-20-22(10-18)32-26(31-20)14-2-3-14/h4-14,30H,2-3,27H2,1H3,(H,31,32)
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n/an/a 45n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357251
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccc(Br)cc2[nH]1
Show InChI InChI=1S/C22H17BrN6O/c23-13-4-3-12-7-19(26-17(12)8-13)20(30)15-10-25-29(21(15)24)14-5-6-16-18(9-14)28-22(27-16)11-1-2-11/h3-11,26H,1-2,24H2,(H,27,28)
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n/an/a 46n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357247
PNG
(Methyl 5-(5-amino-4-(1H-indole-2-carbonyl)-1H-pyra...)
Show SMILES COC(=O)c1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C21H16N6O3/c1-30-21(29)20-25-15-7-6-12(9-16(15)26-20)27-19(22)13(10-23-27)18(28)17-8-11-4-2-3-5-14(11)24-17/h2-10,24H,22H2,1H3,(H,25,26)
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n/an/a 75.3n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357247
PNG
(Methyl 5-(5-amino-4-(1H-indole-2-carbonyl)-1H-pyra...)
Show SMILES COC(=O)c1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C21H16N6O3/c1-30-21(29)20-25-15-7-6-12(9-16(15)26-20)27-19(22)13(10-23-27)18(28)17-8-11-4-2-3-5-14(11)24-17/h2-10,24H,22H2,1H3,(H,25,26)
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n/an/a>100n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357254
PNG
(2-(5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccc(cc2[nH]1)C#N
Show InChI InChI=1S/C23H17N7O/c24-10-12-1-2-14-8-20(27-18(14)7-12)21(31)16-11-26-30(22(16)25)15-5-6-17-19(9-15)29-23(28-17)13-3-4-13/h1-2,5-9,11,13,27H,3-4,25H2,(H,28,29)
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n/an/a 135n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357253
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES CCn1cc(cn1)-c1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C27H24N8O/c1-2-34-14-18(12-29-34)16-5-6-17-10-24(31-22(17)9-16)25(36)20-13-30-35(26(20)28)19-7-8-21-23(11-19)33-27(32-21)15-3-4-15/h5-15,31H,2-4,28H2,1H3,(H,32,33)
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n/an/a 280n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357250
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccc(F)cc2[nH]1
Show InChI InChI=1S/C22H17FN6O/c23-13-4-3-12-7-19(26-17(12)8-13)20(30)15-10-25-29(21(15)24)14-5-6-16-18(9-14)28-22(27-16)11-1-2-11/h3-11,26H,1-2,24H2,(H,27,28)
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n/an/a 308n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357246
PNG
((5-amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C22H18N6O/c23-21-15(20(29)19-9-13-3-1-2-4-16(13)25-19)11-24-28(21)14-7-8-17-18(10-14)27-22(26-17)12-5-6-12/h1-4,7-12,25H,5-6,23H2,(H,26,27)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357252
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Cn1cc(cn1)-c1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C26H22N8O/c1-33-13-17(11-28-33)15-4-5-16-9-23(30-21(16)8-15)24(35)19-12-29-34(25(19)27)18-6-7-20-22(10-18)32-26(31-20)14-2-3-14/h4-14,30H,2-3,27H2,1H3,(H,31,32)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357249
PNG
((5-amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C22H17FN6O/c23-13-3-5-16-12(7-13)8-19(26-16)20(30)15-10-25-29(21(15)24)14-4-6-17-18(9-14)28-22(27-17)11-1-2-11/h3-11,26H,1-2,24H2,(H,27,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357251
PNG
((5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl...)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccc(Br)cc2[nH]1
Show InChI InChI=1S/C22H17BrN6O/c23-13-4-3-12-7-19(26-17(12)8-13)20(30)15-10-25-29(21(15)24)14-5-6-16-18(9-14)28-22(27-16)11-1-2-11/h3-11,26H,1-2,24H2,(H,27,28)
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n/an/a 1.74E+3n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357248
PNG
(Ethyl 5-(5-Amino-4-(1H-indole-2-carbonyl)-1H-pyraz...)
Show SMILES CCOC(=O)c1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C22H18N6O3/c1-2-31-22(30)21-26-16-8-7-13(10-17(16)27-21)28-20(23)14(11-24-28)19(29)18-9-12-5-3-4-6-15(12)25-18/h3-11,25H,2,23H2,1H3,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357248
PNG
(Ethyl 5-(5-Amino-4-(1H-indole-2-carbonyl)-1H-pyraz...)
Show SMILES CCOC(=O)c1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C22H18N6O3/c1-2-31-22(30)21-26-16-8-7-13(10-17(16)27-21)28-20(23)14(11-24-28)19(29)18-9-12-5-3-4-6-15(12)25-18/h3-11,25H,2,23H2,1H3,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357247
PNG
(Methyl 5-(5-amino-4-(1H-indole-2-carbonyl)-1H-pyra...)
Show SMILES COC(=O)c1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C21H16N6O3/c1-30-21(29)20-25-15-7-6-12(9-16(15)26-20)27-19(22)13(10-23-27)18(28)17-8-11-4-2-3-5-14(11)24-17/h2-10,24H,22H2,1H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357248
PNG
(Ethyl 5-(5-Amino-4-(1H-indole-2-carbonyl)-1H-pyraz...)
Show SMILES CCOC(=O)c1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C22H18N6O3/c1-2-31-22(30)21-26-16-8-7-13(10-17(16)27-21)28-20(23)14(11-24-28)19(29)18-9-12-5-3-4-6-15(12)25-18/h3-11,25H,2,23H2,1H3,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...


US Patent US10214515 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%