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Patent code US10214519

Compile Data Set for Download or QSAR

Found 354 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357496
PNG
(US10214519, Example 240)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)N1CCOCC1)-c1nccs1
Show InChI InChI=1S/C24H19ClFN5OS/c1-14-29-22-16(24-28-6-11-33-24)12-15(30-7-9-32-10-8-30)13-20(22)31(14)19-4-5-27-23-17(25)2-3-18(26)21(19)23/h2-6,11-13H,7-10H2,1H3
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357571
PNG
(US10214519, Example 332)
Show SMILES Clc1cccc2c(ccnc12)-n1cnc2c(cc(cc12)N1CCOCC1)-c1c[nH]cn1
Show InChI InChI=1S/C23H19ClN6O/c24-18-3-1-2-16-20(4-5-26-22(16)18)30-14-28-23-17(19-12-25-13-27-19)10-15(11-21(23)30)29-6-8-31-9-7-29/h1-5,10-14H,6-9H2,(H,25,27)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357597
PNG
(US10214519, Example 360 | US10214519, Example 361)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C23H20ClN7O/c1-14-28-22-17(23-26-13-27-29-23)11-15(30-7-9-32-10-8-30)12-20(22)31(14)19-5-6-25-21-16(19)3-2-4-18(21)24/h2-6,11-13H,7-10H2,1H3,(H,26,27,29)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357385
PNG
(US10214519, Example 111)
Show SMILES Clc1cccc2c(ccnc12)-n1cnc2c(cc(cc12)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C22H18ClN7O/c23-17-3-1-2-15-18(4-5-24-20(15)17)30-13-26-21-16(22-25-12-27-28-22)10-14(11-19(21)30)29-6-8-31-9-7-29/h1-5,10-13H,6-9H2,(H,25,27,28)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357480
PNG
(US10214519, Example 224)
Show SMILES Clc1cccc2c(ccnc12)-n1cnc2c(cc(cc12)N1CCOCC1)-c1ncco1
Show InChI InChI=1S/C23H18ClN5O2/c24-18-3-1-2-16-19(4-5-25-21(16)18)29-14-27-22-17(23-26-6-9-31-23)12-15(13-20(22)29)28-7-10-30-11-8-28/h1-6,9,12-14H,7-8,10-11H2
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357302
PNG
(US10214519, Example 28)
Show SMILES Fc1ccc(F)c2c(ccnc12)-n1cnc2c(cc(cc12)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C22H17F2N7O/c23-15-1-2-16(24)21-19(15)17(3-4-25-21)31-12-27-20-14(22-26-11-28-29-22)9-13(10-18(20)31)30-5-7-32-8-6-30/h1-4,9-12H,5-8H2,(H,26,28,29)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357275
PNG
(US10214519, Example 1)
Show SMILES CCCc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C25H24ClN7O/c1-2-4-22-30-24-18(25-28-15-29-31-25)13-16(32-9-11-34-12-10-32)14-21(24)33(22)20-7-8-27-23-17(20)5-3-6-19(23)26/h3,5-8,13-15H,2,4,9-12H2,1H3,(H,28,29,31)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357529
PNG
(US10214519, Example 285)
Show SMILES Clc1ncc([nH]1)-c1cc(cc2n(cnc12)-c1ccnc2c(Cl)cccc12)N1CCOCC1
Show InChI InChI=1S/C23H18Cl2N6O/c24-17-3-1-2-15-19(4-5-26-21(15)17)31-13-28-22-16(18-12-27-23(25)29-18)10-14(11-20(22)31)30-6-8-32-9-7-30/h1-5,10-13H,6-9H2,(H,27,29)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357494
PNG
(US10214519, Example 238)
Show SMILES Cc1csc(n1)-c1cc(cc2n(c(C)nc12)-c1ccnc2c(Cl)ccc(F)c12)N1CCOCC1
Show InChI InChI=1S/C25H21ClFN5OS/c1-14-13-34-25(29-14)17-11-16(31-7-9-33-10-8-31)12-21-23(17)30-15(2)32(21)20-5-6-28-24-18(26)3-4-19(27)22(20)24/h3-6,11-13H,7-10H2,1-2H3
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357522
PNG
(US10214519, Example 278)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)N1CCOCC1)-c1cnc(Cl)[nH]1
Show InChI InChI=1S/C24H20Cl2N6O/c1-14-29-23-17(19-13-28-24(26)30-19)11-15(31-7-9-33-10-8-31)12-21(23)32(14)20-5-6-27-22-16(20)3-2-4-18(22)25/h2-6,11-13H,7-10H2,1H3,(H,28,30)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357362
PNG
(US10214519, Example 88)
Show SMILES FC(F)c1cc(-n2cnc3c(cc(cc23)N2CCOCC2)-c2nnc[nH]2)c2cccc(Cl)c2n1
Show InChI InChI=1S/C23H18ClF2N7O/c24-16-3-1-2-14-18(10-17(22(25)26)30-20(14)16)33-12-28-21-15(23-27-11-29-31-23)8-13(9-19(21)33)32-4-6-34-7-5-32/h1-3,8-12,22H,4-7H2,(H,27,29,31)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357575
PNG
(US10214519, Example 336)
Show SMILES Fc1ccc(F)c2c(ccnc12)-n1cnc2c(cc(cc12)N1CCOCC1)-c1cnc[nH]1
Show InChI InChI=1S/C23H18F2N6O/c24-16-1-2-17(25)23-21(16)19(3-4-27-23)31-13-29-22-15(18-11-26-12-28-18)9-14(10-20(22)31)30-5-7-32-8-6-30/h1-4,9-13H,5-8H2,(H,26,28)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357485
PNG
(US10214519, Example 229)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)N1CCOCC1)-c1ncco1
Show InChI InChI=1S/C24H19F2N5O2/c1-14-29-22-16(24-28-6-9-33-24)12-15(30-7-10-32-11-8-30)13-20(22)31(14)19-4-5-27-23-18(26)3-2-17(25)21(19)23/h2-6,9,12-13H,7-8,10-11H2,1H3
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357486
PNG
(US10214519, Example 230 | US10214519, Example 356 ...)
Show SMILES CCCc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)N1CCOCC1)-c1ncco1
Show InChI InChI=1S/C26H23F2N5O2/c1-2-3-22-31-24-17(26-30-8-11-35-26)14-16(32-9-12-34-13-10-32)15-21(24)33(22)20-6-7-29-25-19(28)5-4-18(27)23(20)25/h4-8,11,14-15H,2-3,9-10,12-13H2,1H3
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357532
PNG
(US10214519, Example 288)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)N1CCOCC1)-c1cnc(Cl)[nH]1
Show InChI InChI=1S/C24H19Cl2FN6O/c1-13-30-22-15(18-12-29-24(26)31-18)10-14(32-6-8-34-9-7-32)11-20(22)33(13)19-4-5-28-23-16(25)2-3-17(27)21(19)23/h2-5,10-12H,6-9H2,1H3,(H,29,31)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357569
PNG
(US10214519, Example 330)
Show SMILES Cc1cc(-n2cnc3c(cc(cc23)N2CCOCC2)-c2cnc[nH]2)c2c(Cl)ccc(Cl)c2n1
Show InChI InChI=1S/C24H20Cl2N6O/c1-14-8-20(22-17(25)2-3-18(26)24(22)30-14)32-13-29-23-16(19-11-27-12-28-19)9-15(10-21(23)32)31-4-6-33-7-5-31/h2-3,8-13H,4-7H2,1H3,(H,27,28)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357492
PNG
(US10214519, Example 236)
Show SMILES Fc1ccc(F)c2c(ccnc12)-n1cnc2c(cc(cc12)N1CCOCC1)-c1ncco1
Show InChI InChI=1S/C23H17F2N5O2/c24-16-1-2-17(25)22-20(16)18(3-4-26-22)30-13-28-21-15(23-27-5-8-32-23)11-14(12-19(21)30)29-6-9-31-10-7-29/h1-5,8,11-13H,6-7,9-10H2
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357581
PNG
(US10214519, Example 344 | US10214519, Example 345)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(Cl)c12)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C23H19ClFN7O/c1-13-29-21-15(23-27-12-28-30-23)10-14(31-6-8-33-9-7-31)11-19(21)32(13)18-4-5-26-22-17(25)3-2-16(24)20(18)22/h2-5,10-12H,6-9H2,1H3,(H,27,28,30)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357530
PNG
(US10214519, Example 286 | US10214519, Example 342 ...)
Show SMILES Fc1ccc(F)c2c(ccnc12)-n1c(nc2c(cc(cc12)N1CCOCC1)-c1cnc(Cl)[nH]1)C1CC1
Show InChI InChI=1S/C26H21ClF2N6O/c27-26-31-13-19(32-26)16-11-15(34-7-9-36-10-8-34)12-21-23(16)33-25(14-1-2-14)35(21)20-5-6-30-24-18(29)4-3-17(28)22(20)24/h3-6,11-14H,1-2,7-10H2,(H,31,32)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357482
PNG
(US10214519, Example 226)
Show SMILES CCc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)N1CCOCC1)-c1ncco1
Show InChI InChI=1S/C25H22ClN5O2/c1-2-22-29-24-18(25-28-8-11-33-25)14-16(30-9-12-32-13-10-30)15-21(24)31(22)20-6-7-27-23-17(20)4-3-5-19(23)26/h3-8,11,14-15H,2,9-10,12-13H2,1H3
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357538
PNG
(US10214519, Example 294)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)c(F)ccc12)N1CCOCC1)-c1cnc(Cl)[nH]1
Show InChI InChI=1S/C24H19Cl2FN6O/c1-13-30-22-16(18-12-29-24(26)31-18)10-14(32-6-8-34-9-7-32)11-20(22)33(13)19-4-5-28-23-15(19)2-3-17(27)21(23)25/h2-5,10-12H,6-9H2,1H3,(H,29,31)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357552
PNG
(US10214519, Example 308)
Show SMILES Fc1ccc(F)c2c(ccnc12)-n1cnc2c(cc(cc12)N1CCOCC1)-c1cnc(Cl)[nH]1
Show InChI InChI=1S/C23H17ClF2N6O/c24-23-28-11-17(30-23)14-9-13(31-5-7-33-8-6-31)10-19-21(14)29-12-32(19)18-3-4-27-22-16(26)2-1-15(25)20(18)22/h1-4,9-12H,5-8H2,(H,28,30)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357456
PNG
(US10214519, Example 200 | US10214519, Example 340 ...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)cccc12)N1CCOCC1)-c1ncco1
Show InChI InChI=1S/C24H20FN5O2/c1-15-28-23-18(24-27-7-10-32-24)13-16(29-8-11-31-12-9-29)14-21(23)30(15)20-5-6-26-22-17(20)3-2-4-19(22)25/h2-7,10,13-14H,8-9,11-12H2,1H3
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357369
PNG
(US10214519, Example 95)
Show SMILES Fc1cccc2c(ccnc12)-n1cnc2c(cc(cc12)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C22H18FN7O/c23-17-3-1-2-15-18(4-5-24-20(15)17)30-13-26-21-16(22-25-12-27-28-22)10-14(11-19(21)30)29-6-8-31-9-7-29/h1-5,10-13H,6-9H2,(H,25,27,28)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357609
PNG
(US10214519, Example 372 | US10214519, Example 373)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)N1CCOCC1)-c1cnc(Cl)[nH]1
Show InChI InChI=1S/C24H19ClF2N6O/c1-13-30-22-15(18-12-29-24(25)31-18)10-14(32-6-8-34-9-7-32)11-20(22)33(13)19-4-5-28-23-17(27)3-2-16(26)21(19)23/h2-5,10-12H,6-9H2,1H3,(H,29,31)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357498
PNG
(US10214519, Example 242)
Show SMILES Fc1ccc(Cl)c2nccc(-n3c(nc4c(cc(cc34)N3CCOCC3)-c3ncco3)C3CC3)c12
Show InChI InChI=1S/C26H21ClFN5O2/c27-18-3-4-19(28)22-20(5-6-29-24(18)22)33-21-14-16(32-8-11-34-12-9-32)13-17(26-30-7-10-35-26)23(21)31-25(33)15-1-2-15/h3-7,10,13-15H,1-2,8-9,11-12H2
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357524
PNG
(US10214519, Example 280 | US10214519, Example 346 ...)
Show SMILES CCc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)N1CCOCC1)-c1cnc(Cl)[nH]1
Show InChI InChI=1S/C25H21ClF2N6O/c1-2-21-32-23-15(18-13-30-25(26)31-18)11-14(33-7-9-35-10-8-33)12-20(23)34(21)19-5-6-29-24-17(28)4-3-16(27)22(19)24/h3-6,11-13H,2,7-10H2,1H3,(H,30,31)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357589
PNG
(US10214519, Example 352 | US10214519, Example 353)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)c(F)ccc12)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C23H19F2N7O/c1-13-29-21-16(23-27-12-28-30-23)10-14(31-6-8-33-9-7-31)11-19(21)32(13)18-4-5-26-22-15(18)2-3-17(24)20(22)25/h2-5,10-12H,6-9H2,1H3,(H,27,28,30)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357303
PNG
(US10214519, Example 29)
Show SMILES Fc1ccc2c(ccnc2c1Cl)-n1cnc2c(cc(cc12)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C22H17ClFN7O/c23-19-16(24)2-1-14-17(3-4-25-21(14)19)31-12-27-20-15(22-26-11-28-29-22)9-13(10-18(20)31)30-5-7-32-8-6-30/h1-4,9-12H,5-8H2,(H,26,28,29)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357375
PNG
(US10214519, Example 101)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C23H20ClN7O/c1-14-28-22-17(23-26-13-27-29-23)11-15(30-7-9-32-10-8-30)12-20(22)31(14)19-5-6-25-21-16(19)3-2-4-18(21)24/h2-6,11-13H,7-10H2,1H3,(H,26,27,29)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357486
PNG
(US10214519, Example 230 | US10214519, Example 356 ...)
Show SMILES CCCc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)N1CCOCC1)-c1ncco1
Show InChI InChI=1S/C26H23F2N5O2/c1-2-3-22-31-24-17(26-30-8-11-35-26)14-16(32-9-12-34-13-10-32)15-21(24)33(22)20-6-7-29-25-19(28)5-4-18(27)23(20)25/h4-8,11,14-15H,2-3,9-10,12-13H2,1H3
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357440
PNG
(US10214519, Example 170)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)N1CCOCC1)-c1nnc(Cl)[nH]1
Show InChI InChI=1S/C23H18Cl2FN7O/c1-12-28-20-14(22-29-23(25)31-30-22)10-13(32-6-8-34-9-7-32)11-18(20)33(12)17-4-5-27-21-15(24)2-3-16(26)19(17)21/h2-5,10-11H,6-9H2,1H3,(H,29,30,31)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357568
PNG
(US10214519, Example 329)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)N1CCOCC1)-c1cnn[nH]1
Show InChI InChI=1S/C23H20ClN7O/c1-14-27-23-17(19-13-26-29-28-19)11-15(30-7-9-32-10-8-30)12-21(23)31(14)20-5-6-25-22-16(20)3-2-4-18(22)24/h2-6,11-13H,7-10H2,1H3,(H,26,28,29)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357570
PNG
(US10214519, Example 331)
Show SMILES CCc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)N1CCOCC1)-c1c[nH]cn1
Show InChI InChI=1S/C25H23ClN6O/c1-2-23-30-25-18(20-14-27-15-29-20)12-16(31-8-10-33-11-9-31)13-22(25)32(23)21-6-7-28-24-17(21)4-3-5-19(24)26/h3-7,12-15H,2,8-11H2,1H3,(H,27,29)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357476
PNG
(US10214519, Example 220)
Show SMILES Clc1cccc2c(ccnc12)-n1c(CC2CC2)nc2c(cc(cc12)N1CCOCC1)-c1ncco1
Show InChI InChI=1S/C27H24ClN5O2/c28-21-3-1-2-19-22(6-7-29-25(19)21)33-23-16-18(32-9-12-34-13-10-32)15-20(27-30-8-11-35-27)26(23)31-24(33)14-17-4-5-17/h1-3,6-8,11,15-17H,4-5,9-10,12-14H2
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357591
PNG
(US10214519, Example 354 | US10214519, Example 355)
Show SMILES CCCc1nc2c(cc(cc2n1-c1ccnc2c(F)cccc12)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C25H24FN7O/c1-2-4-22-30-24-18(25-28-15-29-31-25)13-16(32-9-11-34-12-10-32)14-21(24)33(22)20-7-8-27-23-17(20)5-3-6-19(23)26/h3,5-8,13-15H,2,4,9-12H2,1H3,(H,28,29,31)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357342
PNG
(US10214519, Example 68)
Show SMILES Cc1nc2c(cc(cc2n1-c1c(C)cnc2c(Cl)cccc12)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C24H22ClN7O/c1-14-12-26-21-17(4-3-5-19(21)25)23(14)32-15(2)29-22-18(24-27-13-28-30-24)10-16(11-20(22)32)31-6-8-33-9-7-31/h3-5,10-13H,6-9H2,1-2H3,(H,27,28,30)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357489
PNG
(US10214519, Example 233)
Show SMILES Cc1csc(n1)-c1cc(cc2n(c(C)nc12)-c1ccnc2c(F)ccc(F)c12)N1CCOCC1
Show InChI InChI=1S/C25H21F2N5OS/c1-14-13-34-25(29-14)17-11-16(31-7-9-33-10-8-31)12-21-23(17)30-15(2)32(21)20-5-6-28-24-19(27)4-3-18(26)22(20)24/h3-6,11-13H,7-10H2,1-2H3
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357460
PNG
(US10214519, Example 204)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)N1CCOCC1)-c1ncco1
Show InChI InChI=1S/C24H20ClN5O2/c1-15-28-23-18(24-27-7-10-32-24)13-16(29-8-11-31-12-9-29)14-21(23)30(15)20-5-6-26-22-17(20)3-2-4-19(22)25/h2-7,10,13-14H,8-9,11-12H2,1H3
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357475
PNG
(US10214519, Example 219)
Show SMILES CC(C)Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)N1CCOCC1)-c1ncco1
Show InChI InChI=1S/C27H25F2N5O2/c1-16(2)13-23-32-25-18(27-31-7-10-36-27)14-17(33-8-11-35-12-9-33)15-22(25)34(23)21-5-6-30-26-20(29)4-3-19(28)24(21)26/h3-7,10,14-16H,8-9,11-13H2,1-2H3
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357616
PNG
(US10214519, Example 379)
Show SMILES C1CN(CCN1)c1cc(-n2cnc3c(cc(cc23)N2CCOCC2)-c2nnc[nH]2)c2ccccc2n1
Show InChI InChI=1S/C26H27N9O/c1-2-4-21-19(3-1)22(15-24(31-21)34-7-5-27-6-8-34)35-17-29-25-20(26-28-16-30-32-26)13-18(14-23(25)35)33-9-11-36-12-10-33/h1-4,13-17,27H,5-12H2,(H,28,30,32)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357304
PNG
(US10214519, Example 30)
Show SMILES Clc1cccc2c(ccnc12)-n1c(nc2c(cc(cc12)N1CCOCC1)-c1nnc[nH]1)C1CCC1
Show InChI InChI=1S/C26H24ClN7O/c27-20-6-2-5-18-21(7-8-28-23(18)20)34-22-14-17(33-9-11-35-12-10-33)13-19(25-29-15-30-32-25)24(22)31-26(34)16-3-1-4-16/h2,5-8,13-16H,1,3-4,9-12H2,(H,29,30,32)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357551
PNG
(US10214519, Example 307)
Show SMILES Fc1ccc(Cl)c2nccc(-n3c(nc4c(cc(cc34)N3CCOCC3)-c3cnc(Cl)[nH]3)C3CC3)c12
Show InChI InChI=1S/C26H21Cl2FN6O/c27-17-3-4-18(29)22-20(5-6-30-24(17)22)35-21-12-15(34-7-9-36-10-8-34)11-16(19-13-31-26(28)32-19)23(21)33-25(35)14-1-2-14/h3-6,11-14H,1-2,7-10H2,(H,31,32)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357356
PNG
(US10214519, Example 82)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(cccc12)C(F)F)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C24H21F2N7O/c1-14-30-22-18(24-28-13-29-31-24)11-15(32-7-9-34-10-8-32)12-20(22)33(14)19-5-6-27-21-16(19)3-2-4-17(21)23(25)26/h2-6,11-13,23H,7-10H2,1H3,(H,28,29,31)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357456
PNG
(US10214519, Example 200 | US10214519, Example 340 ...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)cccc12)N1CCOCC1)-c1ncco1
Show InChI InChI=1S/C24H20FN5O2/c1-15-28-23-18(24-27-7-10-32-24)13-16(29-8-11-31-12-9-29)14-21(23)30(15)20-5-6-26-22-17(20)3-2-4-19(22)25/h2-7,10,13-14H,8-9,11-12H2,1H3
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357500
PNG
(US10214519, Example 244)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)N1CCOCC1)-c1nccs1
Show InChI InChI=1S/C24H20ClN5OS/c1-15-28-23-18(24-27-7-12-32-24)13-16(29-8-10-31-11-9-29)14-21(23)30(15)20-5-6-26-22-17(20)3-2-4-19(22)25/h2-7,12-14H,8-11H2,1H3
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357479
PNG
(US10214519, Example 223)
Show SMILES CCCc1nc2c(cc(cc2n1-c1ccnc2c(F)cccc12)N1CCOCC1)-c1ncco1
Show InChI InChI=1S/C26H24FN5O2/c1-2-4-23-30-25-19(26-29-9-12-34-26)15-17(31-10-13-33-14-11-31)16-22(25)32(23)21-7-8-28-24-18(21)5-3-6-20(24)27/h3,5-9,12,15-16H,2,4,10-11,13-14H2,1H3
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357306
PNG
(US10214519, Example 32)
Show SMILES Clc1cccc2c(ccnc12)-n1c(CC2CC2)nc2c(cc(cc12)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C26H24ClN7O/c27-20-3-1-2-18-21(6-7-28-24(18)20)34-22-14-17(33-8-10-35-11-9-33)13-19(26-29-15-30-32-26)25(22)31-23(34)12-16-4-5-16/h1-3,6-7,13-16H,4-5,8-12H2,(H,29,30,32)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357626
PNG
(US10214519, Example 392)
Show SMILES Cc1nc2c(cc(cc2n1-c1c(cnc2ccccc12)-c1nnc[nH]1)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C25H22N10O/c1-15-31-22-18(24-27-13-29-32-24)10-16(34-6-8-36-9-7-34)11-21(22)35(15)23-17-4-2-3-5-20(17)26-12-19(23)25-28-14-30-33-25/h2-5,10-14H,6-9H2,1H3,(H,27,29,32)(H,28,30,33)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357305
PNG
(US10214519, Example 31)
Show SMILES Fc1ccc2c(ccnc2c1Cl)-n1c(CC2CC2)nc2c(cc(cc12)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C26H23ClFN7O/c27-23-19(28)4-3-17-20(5-6-29-25(17)23)35-21-13-16(34-7-9-36-10-8-34)12-18(26-30-14-31-33-26)24(21)32-22(35)11-15-1-2-15/h3-6,12-15H,1-2,7-11H2,(H,30,31,33)
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Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%