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Patent code US10214528

Compile Data Set for Download or QSAR
Found 152 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357711
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isoprop...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C(C)C)C2=O)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-6-18(29)26-10-14-7-15-13(9-25-14)11-27(22(30)28(15)12(2)3)21-19(23)16(31-4)8-17(32-5)20(21)24/h6-9,12H,1,10-11H2,2-5H3,(H,26,29)
PDB

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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357716
PNG
(N-((1-(cyanomethyl)-3-(2,6-difluoro-3,5-dimethoxyp...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC#N)C2=O)c1F
Show InChI InChI=1S/C21H19F2N5O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-24)20-18(22)15(31-2)8-16(32-3)19(20)23/h4,7-9H,1,6,10-11H2,2-3H3,(H,26,29)
PDB

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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357727
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@@H]3CCOC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/m0/s1
PDB

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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357726
PNG
(N-((1-(cyclobutylmethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-11-16-8-17-15(10-27-16)13-30(24(32)29(17)12-14-6-5-7-14)23-21(25)18(33-2)9-19(34-3)22(23)26/h4,8-10,14H,1,5-7,11-13H2,2-3H3,(H,28,31)
PDB

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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357701
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H25F2N3O4/c1-4-19(30)28-12-15-9-16-14(11-27-15)13-29(23(31)24(16)7-5-6-8-24)22-20(25)17(32-2)10-18(33-3)21(22)26/h4,9-11H,1,5-8,12-13H2,2-3H3,(H,28,30)
PDB

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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357729
PNG
(US10214528, Example 33 | methyl 4-((7-(acrylamidom...)
Show SMILES COC(=O)N1CCC(CN2C(=O)N(Cc3cnc(CNC(=O)C=C)cc23)c2c(F)c(OC)cc(OC)c2F)CC1
Show InChI InChI=1S/C27H31F2N5O6/c1-5-22(35)31-13-18-10-19-17(12-30-18)15-34(25-23(28)20(38-2)11-21(39-3)24(25)29)26(36)33(19)14-16-6-8-32(9-7-16)27(37)40-4/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,31,35)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357698
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C21H22F2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
PDB

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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357731
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-(me...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)S(C)(=O)=O)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O6S/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(38-2)11-21(39-3)24(25)28)26(35)32(19)14-16-6-8-31(9-7-16)40(4,36)37/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357715
PNG
((R)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/m1/s1
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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357708
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES CCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-5-7-27-15-8-14(11-26-18(29)6-2)25-10-13(15)12-28(22(27)30)21-19(23)16(31-3)9-17(32-4)20(21)24/h6,8-10H,2,5,7,11-12H2,1,3-4H3,(H,26,29)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
PDB

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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357732
PNG
(N-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C21H22Cl2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357710
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2,2-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)F)C2=O)c1F
Show InChI InChI=1S/C21H20F4N4O4/c1-4-17(30)27-8-12-5-13-11(7-26-12)9-29(21(31)28(13)10-16(22)23)20-18(24)14(32-2)6-15(33-3)19(20)25/h4-7,16H,1,8-10H2,2-3H3,(H,27,30)
PDB

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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357730
PNG
(4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)C(=O)NC(C)C)C2=O)c1F
Show InChI InChI=1S/C29H36F2N6O5/c1-6-24(38)33-14-20-11-21-19(13-32-20)16-37(27-25(30)22(41-4)12-23(42-5)26(27)31)29(40)36(21)15-18-7-9-35(10-8-18)28(39)34-17(2)3/h6,11-13,17-18H,1,7-10,14-16H2,2-5H3,(H,33,38)(H,34,39)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357714
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C24H24F2N6O4/c1-5-20(33)28-10-16-6-17-15(9-27-16)13-32(24(34)31(17)12-14-8-29-30(2)11-14)23-21(25)18(35-3)7-19(36-4)22(23)26/h5-9,11H,1,10,12-13H2,2-4H3,(H,28,33)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357724
PNG
(N-((1-cyclopentyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-7-5-6-8-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357704
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N([C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O5/c1-4-19(30)27-10-14-7-16-13(9-26-14)11-28(23(31)29(16)15-5-6-34-12-15)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,15H,1,5-6,10-12H2,2-3H3,(H,27,30)/t15-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357707
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-meth...)
Show SMILES COCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O5/c1-5-18(29)26-11-14-8-15-13(10-25-14)12-28(22(30)27(15)6-7-31-2)21-19(23)16(32-3)9-17(33-4)20(21)24/h5,8-10H,1,6-7,11-12H2,2-4H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357717
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)(F)F)C2=O)c1F
Show InChI InChI=1S/C21H19F5N4O4/c1-4-16(31)28-8-12-5-13-11(7-27-12)9-29(20(32)30(13)10-21(24,25)26)19-17(22)14(33-2)6-15(34-3)18(19)23/h4-7H,1,8-10H2,2-3H3,(H,28,31)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357723
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CCF)C2=O)c1F
Show InChI InChI=1S/C21H21F3N4O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-22)20-18(23)15(31-2)8-16(32-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,29)
PDB

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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357725
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isobuty...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(C)C)C2=O)c1F
Show InChI InChI=1S/C23H26F2N4O4/c1-6-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13(2)3)22-20(24)17(32-4)8-18(33-5)21(22)25/h6-9,13H,1,10-12H2,2-5H3,(H,27,30)
PDB

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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
PDB

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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357709
PNG
(N-((1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13-5-6-13)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,13H,1,5-6,10-12H2,2-3H3,(H,27,30)
PDB

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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357722
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccncc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-12-15-9-17-14(11-28-15)13-30(24(33)31(17)16-5-7-27-8-6-16)23-21(25)18(34-2)10-19(35-3)22(23)26/h4-11H,1,12-13H2,2-3H3,(H,29,32)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357712
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccc(F)c3)C2=O)c1F
Show InChI InChI=1S/C26H23F3N4O4/c1-4-22(34)31-12-18-9-19-16(11-30-18)14-33(25-23(28)20(36-2)10-21(37-3)24(25)29)26(35)32(19)13-15-6-5-7-17(27)8-15/h4-11H,1,12-14H2,2-3H3,(H,31,34)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357705
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3,3-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC(F)(F)C3)C2=O)c1F
Show InChI InChI=1S/C23H22F4N4O4/c1-4-18(32)29-10-13-5-15-12(9-28-13)11-30(22(33)31(15)14-7-23(26,27)8-14)21-19(24)16(34-2)6-17(35-3)20(21)25/h4-6,9,14H,1,7-8,10-11H2,2-3H3,(H,29,32)
PDB

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n/an/a 20n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357706
PNG
(N-((1-cyclopropyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC3)C2=O)c1F
Show InChI InChI=1S/C22H22F2N4O4/c1-4-18(29)26-10-13-7-15-12(9-25-13)11-27(22(30)28(15)14-5-6-14)21-19(23)16(31-2)8-17(32-3)20(21)24/h4,7-9,14H,1,5-6,10-11H2,2-3H3,(H,26,29)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357702
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccccc2)c1F
Show InChI InChI=1S/C25H22F2N4O4/c1-4-21(32)29-13-16-10-18-15(12-28-16)14-30(25(33)31(18)17-8-6-5-7-9-17)24-22(26)19(34-2)11-20(35-3)23(24)27/h4-12H,1,13-14H2,2-3H3,(H,29,32)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357699
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2cccnc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-11-15-8-17-14(10-28-15)13-30(24(33)31(17)16-6-5-7-27-12-16)23-21(25)18(34-2)9-19(35-3)22(23)26/h4-10,12H,1,11,13H2,2-3H3,(H,29,32)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357703
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(1-meth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(c3ccn(C)n3)C2=O)c1F
Show InChI InChI=1S/C23H22F2N6O4/c1-5-19(32)27-11-14-8-15-13(10-26-14)12-30(23(33)31(15)18-6-7-29(2)28-18)22-20(24)16(34-3)9-17(35-4)21(22)25/h5-10H,1,11-12H2,2-4H3,(H,27,32)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357733
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)c(C)c3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H23F2N3O4/c1-5-17(29)27-10-14-12(2)18-13(9-26-14)11-28(22(30)23(18)6-7-23)21-19(24)15(31-3)8-16(32-4)20(21)25/h5,8-9H,1,6-7,10-11H2,2-4H3,(H,27,29)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357721
PNG
(N-((1-cyclobutyl-3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-11-14-8-16-13(10-26-14)12-28(23(31)29(16)15-6-5-7-15)22-20(24)17(32-2)9-18(33-3)21(22)25/h4,8-10,15H,1,5-7,11-12H2,2-3H3,(H,27,30)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357718
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C)C2=O)c1F
Show InChI InChI=1S/C20H20F2N4O4/c1-5-16(27)24-9-12-6-13-11(8-23-12)10-26(20(28)25(13)2)19-17(21)14(29-3)7-15(30-4)18(19)22/h5-8H,1,9-10H2,2-4H3,(H,24,27)
PDB

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US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357713
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccnc3)C2=O)c1F
Show InChI InChI=1S/C25H23F2N5O4/c1-4-21(33)30-12-17-8-18-16(11-29-17)14-32(25(34)31(18)13-15-6-5-7-28-10-15)24-22(26)19(35-2)9-20(36-3)23(24)27/h4-11H,1,12-14H2,2-3H3,(H,30,33)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357719
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCOCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-5-7-35-8-6-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357700
PNG
(N-((6′-(2,6-difluoro-3,5-dimethoxyphenyl)-7&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C21H20F2N4O4/c1-4-15(28)25-9-14-24-8-11-10-27(20(29)21(5-6-21)19(11)26-14)18-16(22)12(30-2)7-13(31-3)17(18)23/h4,7-8H,1,5-6,9-10H2,2-3H3,(H,25,28)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357712
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccc(F)c3)C2=O)c1F
Show InChI InChI=1S/C26H23F3N4O4/c1-4-22(34)31-12-18-9-19-16(11-30-18)14-33(25-23(28)20(36-2)10-21(37-3)24(25)29)26(35)32(19)13-15-6-5-7-17(27)8-15/h4-11H,1,12-14H2,2-3H3,(H,31,34)
PDB
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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357728
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(C)CC3)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O4/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(36-3)11-21(37-4)24(25)28)26(35)32(19)14-16-6-8-31(2)9-7-16/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
PDB
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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357712
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccc(F)c3)C2=O)c1F
Show InChI InChI=1S/C26H23F3N4O4/c1-4-22(34)31-12-18-9-19-16(11-30-18)14-33(25-23(28)20(36-2)10-21(37-3)24(25)29)26(35)32(19)13-15-6-5-7-17(27)8-15/h4-11H,1,12-14H2,2-3H3,(H,31,34)
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US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357714
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C24H24F2N6O4/c1-5-20(33)28-10-16-6-17-15(9-27-16)13-32(24(34)31(17)12-14-8-29-30(2)11-14)23-21(25)18(35-3)7-19(36-4)22(23)26/h5-9,11H,1,10,12-13H2,2-4H3,(H,28,33)
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US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357714
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C24H24F2N6O4/c1-5-20(33)28-10-16-6-17-15(9-27-16)13-32(24(34)31(17)12-14-8-29-30(2)11-14)23-21(25)18(35-3)7-19(36-4)22(23)26/h5-9,11H,1,10,12-13H2,2-4H3,(H,28,33)
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US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357720
PNG
(N-((7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C22H23F2N3O4/c1-6-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14,2)3)20-18(23)15(30-4)8-16(31-5)19(20)24/h6-9H,1,10-11H2,2-5H3,(H,26,28)
PDB

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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357724
PNG
(N-((1-cyclopentyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-7-5-6-8-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357709
PNG
(N-((1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13-5-6-13)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,13H,1,5-6,10-12H2,2-3H3,(H,27,30)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357712
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccc(F)c3)C2=O)c1F
Show InChI InChI=1S/C26H23F3N4O4/c1-4-22(34)31-12-18-9-19-16(11-30-18)14-33(25-23(28)20(36-2)10-21(37-3)24(25)29)26(35)32(19)13-15-6-5-7-17(27)8-15/h4-11H,1,12-14H2,2-3H3,(H,31,34)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357719
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCOCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-5-7-35-8-6-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357726
PNG
(N-((1-(cyclobutylmethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-11-16-8-17-15(10-27-16)13-30(24(32)29(17)12-14-6-5-7-14)23-21(25)18(33-2)9-19(34-3)22(23)26/h4,8-10,14H,1,5-7,11-13H2,2-3H3,(H,28,31)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357709
PNG
(N-((1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13-5-6-13)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,13H,1,5-6,10-12H2,2-3H3,(H,27,30)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357714
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C24H24F2N6O4/c1-5-20(33)28-10-16-6-17-15(9-27-16)13-32(24(34)31(17)12-14-8-29-30(2)11-14)23-21(25)18(35-3)7-19(36-4)22(23)26/h5-9,11H,1,10,12-13H2,2-4H3,(H,28,33)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357725
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isobuty...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(C)C)C2=O)c1F
Show InChI InChI=1S/C23H26F2N4O4/c1-6-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13(2)3)22-20(24)17(32-4)8-18(33-5)21(22)25/h6-9,13H,1,10-12H2,2-5H3,(H,27,30)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357724
PNG
(N-((1-cyclopentyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-7-5-6-8-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357725
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isobuty...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(C)C)C2=O)c1F
Show InChI InChI=1S/C23H26F2N4O4/c1-6-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13(2)3)22-20(24)17(32-4)8-18(33-5)21(22)25/h6-9,13H,1,10-12H2,2-5H3,(H,27,30)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357726
PNG
(N-((1-(cyclobutylmethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-11-16-8-17-15(10-27-16)13-30(24(32)29(17)12-14-6-5-7-14)23-21(25)18(33-2)9-19(34-3)22(23)26/h4,8-10,14H,1,5-7,11-13H2,2-3H3,(H,28,31)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357729
PNG
(US10214528, Example 33 | methyl 4-((7-(acrylamidom...)
Show SMILES COC(=O)N1CCC(CN2C(=O)N(Cc3cnc(CNC(=O)C=C)cc23)c2c(F)c(OC)cc(OC)c2F)CC1
Show InChI InChI=1S/C27H31F2N5O6/c1-5-22(35)31-13-18-10-19-17(12-30-18)15-34(25-23(28)20(38-2)11-21(39-3)24(25)29)26(36)33(19)14-16-6-8-32(9-7-16)27(37)40-4/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,31,35)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357724
PNG
(N-((1-cyclopentyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-7-5-6-8-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357716
PNG
(N-((1-(cyanomethyl)-3-(2,6-difluoro-3,5-dimethoxyp...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC#N)C2=O)c1F
Show InChI InChI=1S/C21H19F2N5O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-24)20-18(22)15(31-2)8-16(32-3)19(20)23/h4,7-9H,1,6,10-11H2,2-3H3,(H,26,29)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357716
PNG
(N-((1-(cyanomethyl)-3-(2,6-difluoro-3,5-dimethoxyp...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC#N)C2=O)c1F
Show InChI InChI=1S/C21H19F2N5O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-24)20-18(22)15(31-2)8-16(32-3)19(20)23/h4,7-9H,1,6,10-11H2,2-3H3,(H,26,29)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357721
PNG
(N-((1-cyclobutyl-3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-11-14-8-16-13(10-26-14)12-28(23(31)29(16)15-6-5-7-15)22-20(24)17(32-2)9-18(33-3)21(22)25/h4,8-10,15H,1,5-7,11-12H2,2-3H3,(H,27,30)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357721
PNG
(N-((1-cyclobutyl-3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-11-14-8-16-13(10-26-14)12-28(23(31)29(16)15-6-5-7-15)22-20(24)17(32-2)9-18(33-3)21(22)25/h4,8-10,15H,1,5-7,11-12H2,2-3H3,(H,27,30)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357721
PNG
(N-((1-cyclobutyl-3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-11-14-8-16-13(10-26-14)12-28(23(31)29(16)15-6-5-7-15)22-20(24)17(32-2)9-18(33-3)21(22)25/h4,8-10,15H,1,5-7,11-12H2,2-3H3,(H,27,30)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357728
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(C)CC3)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O4/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(36-3)11-21(37-4)24(25)28)26(35)32(19)14-16-6-8-31(2)9-7-16/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357698
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C21H22F2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357700
PNG
(N-((6′-(2,6-difluoro-3,5-dimethoxyphenyl)-7&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C21H20F2N4O4/c1-4-15(28)25-9-14-24-8-11-10-27(20(29)21(5-6-21)19(11)26-14)18-16(22)12(30-2)7-13(31-3)17(18)23/h4,7-8H,1,5-6,9-10H2,2-3H3,(H,25,28)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357701
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H25F2N3O4/c1-4-19(30)28-12-15-9-16-14(11-27-15)13-29(23(31)24(16)7-5-6-8-24)22-20(25)17(32-2)10-18(33-3)21(22)26/h4,9-11H,1,5-8,12-13H2,2-3H3,(H,28,30)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357704
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N([C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O5/c1-4-19(30)27-10-14-7-16-13(9-26-14)11-28(23(31)29(16)15-5-6-34-12-15)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,15H,1,5-6,10-12H2,2-3H3,(H,27,30)/t15-/m0/s1
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357706
PNG
(N-((1-cyclopropyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC3)C2=O)c1F
Show InChI InChI=1S/C22H22F2N4O4/c1-4-18(29)26-10-13-7-15-12(9-25-13)11-27(22(30)28(15)14-5-6-14)21-19(23)16(31-2)8-17(32-3)20(21)24/h4,7-9,14H,1,5-6,10-11H2,2-3H3,(H,26,29)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357711
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isoprop...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C(C)C)C2=O)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-6-18(29)26-10-14-7-15-13(9-25-14)11-27(22(30)28(15)12(2)3)21-19(23)16(31-4)8-17(32-5)20(21)24/h6-9,12H,1,10-11H2,2-5H3,(H,26,29)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357715
PNG
((R)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/m1/s1
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357719
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCOCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-5-7-35-8-6-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357727
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@@H]3CCOC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/m0/s1
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357730
PNG
(4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)C(=O)NC(C)C)C2=O)c1F
Show InChI InChI=1S/C29H36F2N6O5/c1-6-24(38)33-14-20-11-21-19(13-32-20)16-37(27-25(30)22(41-4)12-23(42-5)26(27)31)29(40)36(21)15-18-7-9-35(10-8-18)28(39)34-17(2)3/h6,11-13,17-18H,1,7-10,14-16H2,2-5H3,(H,33,38)(H,34,39)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357731
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-(me...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)S(C)(=O)=O)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O6S/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(38-2)11-21(39-3)24(25)28)26(35)32(19)14-16-6-8-31(9-7-16)40(4,36)37/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357732
PNG
(N-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C21H22Cl2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357732
PNG
(N-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C21H22Cl2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357699
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2cccnc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-11-15-8-17-14(10-28-15)13-30(24(33)31(17)16-6-5-7-27-12-16)23-21(25)18(34-2)9-19(35-3)22(23)26/h4-10,12H,1,11,13H2,2-3H3,(H,29,32)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357703
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(1-meth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(c3ccn(C)n3)C2=O)c1F
Show InChI InChI=1S/C23H22F2N6O4/c1-5-19(32)27-11-14-8-15-13(10-26-14)12-30(23(33)31(15)18-6-7-29(2)28-18)22-20(24)16(34-3)9-17(35-4)21(22)25/h5-10H,1,11-12H2,2-4H3,(H,27,32)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357715
PNG
((R)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/m1/s1
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357716
PNG
(N-((1-(cyanomethyl)-3-(2,6-difluoro-3,5-dimethoxyp...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC#N)C2=O)c1F
Show InChI InChI=1S/C21H19F2N5O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-24)20-18(22)15(31-2)8-16(32-3)19(20)23/h4,7-9H,1,6,10-11H2,2-3H3,(H,26,29)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357718
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C)C2=O)c1F
Show InChI InChI=1S/C20H20F2N4O4/c1-5-16(27)24-9-12-6-13-11(8-23-12)10-26(20(28)25(13)2)19-17(21)14(29-3)7-15(30-4)18(19)22/h5-8H,1,9-10H2,2-4H3,(H,24,27)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357718
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C)C2=O)c1F
Show InChI InChI=1S/C20H20F2N4O4/c1-5-16(27)24-9-12-6-13-11(8-23-12)10-26(20(28)25(13)2)19-17(21)14(29-3)7-15(30-4)18(19)22/h5-8H,1,9-10H2,2-4H3,(H,24,27)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357719
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCOCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-5-7-35-8-6-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357720
PNG
(N-((7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C22H23F2N3O4/c1-6-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14,2)3)20-18(23)15(30-4)8-16(31-5)19(20)24/h6-9H,1,10-11H2,2-5H3,(H,26,28)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357723
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CCF)C2=O)c1F
Show InChI InChI=1S/C21H21F3N4O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-22)20-18(23)15(31-2)8-16(32-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,29)
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357699
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2cccnc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-11-15-8-17-14(10-28-15)13-30(24(33)31(17)16-6-5-7-27-12-16)23-21(25)18(34-2)9-19(35-3)22(23)26/h4-10,12H,1,11,13H2,2-3H3,(H,29,32)
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357702
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccccc2)c1F
Show InChI InChI=1S/C25H22F2N4O4/c1-4-21(32)29-13-16-10-18-15(12-28-16)14-30(25(33)31(18)17-8-6-5-7-9-17)24-22(26)19(34-2)11-20(35-3)23(24)27/h4-12H,1,13-14H2,2-3H3,(H,29,32)
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357703
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(1-meth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(c3ccn(C)n3)C2=O)c1F
Show InChI InChI=1S/C23H22F2N6O4/c1-5-19(32)27-11-14-8-15-13(10-26-14)12-30(23(33)31(15)18-6-7-29(2)28-18)22-20(24)16(34-3)9-17(35-4)21(22)25/h5-10H,1,11-12H2,2-4H3,(H,27,32)
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357705
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3,3-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC(F)(F)C3)C2=O)c1F
Show InChI InChI=1S/C23H22F4N4O4/c1-4-18(32)29-10-13-5-15-12(9-28-13)11-30(22(33)31(15)14-7-23(26,27)8-14)21-19(24)16(34-2)6-17(35-3)20(21)25/h4-6,9,14H,1,7-8,10-11H2,2-3H3,(H,29,32)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357706
PNG
(N-((1-cyclopropyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC3)C2=O)c1F
Show InChI InChI=1S/C22H22F2N4O4/c1-4-18(29)26-10-13-7-15-12(9-25-13)11-27(22(30)28(15)14-5-6-14)21-19(23)16(31-2)8-17(32-3)20(21)24/h4,7-9,14H,1,5-6,10-11H2,2-3H3,(H,26,29)
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357708
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES CCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-5-7-27-15-8-14(11-26-18(29)6-2)25-10-13(15)12-28(22(27)30)21-19(23)16(31-3)9-17(32-4)20(21)24/h6,8-10H,2,5,7,11-12H2,1,3-4H3,(H,26,29)
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357717
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)(F)F)C2=O)c1F
Show InChI InChI=1S/C21H19F5N4O4/c1-4-16(31)28-8-12-5-13-11(7-27-12)9-29(20(32)30(13)10-21(24,25)26)19-17(22)14(33-2)6-15(34-3)18(19)23/h4-7H,1,8-10H2,2-3H3,(H,28,31)
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357722
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccncc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-12-15-9-17-14(11-28-15)13-30(24(33)31(17)16-5-7-27-8-6-16)23-21(25)18(34-2)10-19(35-3)22(23)26/h4-11H,1,12-13H2,2-3H3,(H,29,32)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357722
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccncc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-12-15-9-17-14(11-28-15)13-30(24(33)31(17)16-5-7-27-8-6-16)23-21(25)18(34-2)10-19(35-3)22(23)26/h4-11H,1,12-13H2,2-3H3,(H,29,32)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357725
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isobuty...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(C)C)C2=O)c1F
Show InChI InChI=1S/C23H26F2N4O4/c1-6-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13(2)3)22-20(24)17(32-4)8-18(33-5)21(22)25/h6-9,13H,1,10-12H2,2-5H3,(H,27,30)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357729
PNG
(US10214528, Example 33 | methyl 4-((7-(acrylamidom...)
Show SMILES COC(=O)N1CCC(CN2C(=O)N(Cc3cnc(CNC(=O)C=C)cc23)c2c(F)c(OC)cc(OC)c2F)CC1
Show InChI InChI=1S/C27H31F2N5O6/c1-5-22(35)31-13-18-10-19-17(12-30-18)15-34(25-23(28)20(38-2)11-21(39-3)24(25)29)26(36)33(19)14-16-6-8-32(9-7-16)27(37)40-4/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,31,35)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357701
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H25F2N3O4/c1-4-19(30)28-12-15-9-16-14(11-27-15)13-29(23(31)24(16)7-5-6-8-24)22-20(25)17(32-2)10-18(33-3)21(22)26/h4,9-11H,1,5-8,12-13H2,2-3H3,(H,28,30)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357702
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccccc2)c1F
Show InChI InChI=1S/C25H22F2N4O4/c1-4-21(32)29-13-16-10-18-15(12-28-16)14-30(25(33)31(18)17-8-6-5-7-9-17)24-22(26)19(34-2)11-20(35-3)23(24)27/h4-12H,1,13-14H2,2-3H3,(H,29,32)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357706
PNG
(N-((1-cyclopropyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC3)C2=O)c1F
Show InChI InChI=1S/C22H22F2N4O4/c1-4-18(29)26-10-13-7-15-12(9-25-13)11-27(22(30)28(15)14-5-6-14)21-19(23)16(31-2)8-17(32-3)20(21)24/h4,7-9,14H,1,5-6,10-11H2,2-3H3,(H,26,29)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357710
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2,2-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)F)C2=O)c1F
Show InChI InChI=1S/C21H20F4N4O4/c1-4-17(30)27-8-12-5-13-11(7-26-12)9-29(21(31)28(13)10-16(22)23)20-18(24)14(32-2)6-15(33-3)19(20)25/h4-7,16H,1,8-10H2,2-3H3,(H,27,30)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357713
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccnc3)C2=O)c1F
Show InChI InChI=1S/C25H23F2N5O4/c1-4-21(33)30-12-17-8-18-16(11-29-17)14-32(25(34)31(18)13-15-6-5-7-28-10-15)24-22(26)19(35-2)9-20(36-3)23(24)27/h4-11H,1,12-14H2,2-3H3,(H,30,33)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357713
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccnc3)C2=O)c1F
Show InChI InChI=1S/C25H23F2N5O4/c1-4-21(33)30-12-17-8-18-16(11-29-17)14-32(25(34)31(18)13-15-6-5-7-28-10-15)24-22(26)19(35-2)9-20(36-3)23(24)27/h4-11H,1,12-14H2,2-3H3,(H,30,33)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357718
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C)C2=O)c1F
Show InChI InChI=1S/C20H20F2N4O4/c1-5-16(27)24-9-12-6-13-11(8-23-12)10-26(20(28)25(13)2)19-17(21)14(29-3)7-15(30-4)18(19)22/h5-8H,1,9-10H2,2-4H3,(H,24,27)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357723
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CCF)C2=O)c1F
Show InChI InChI=1S/C21H21F3N4O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-22)20-18(23)15(31-2)8-16(32-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357727
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@@H]3CCOC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/m0/s1
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357728
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(C)CC3)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O4/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(36-3)11-21(37-4)24(25)28)26(35)32(19)14-16-6-8-31(2)9-7-16/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357729
PNG
(US10214528, Example 33 | methyl 4-((7-(acrylamidom...)
Show SMILES COC(=O)N1CCC(CN2C(=O)N(Cc3cnc(CNC(=O)C=C)cc23)c2c(F)c(OC)cc(OC)c2F)CC1
Show InChI InChI=1S/C27H31F2N5O6/c1-5-22(35)31-13-18-10-19-17(12-30-18)15-34(25-23(28)20(38-2)11-21(39-3)24(25)29)26(36)33(19)14-16-6-8-32(9-7-16)27(37)40-4/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,31,35)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357730
PNG
(4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)C(=O)NC(C)C)C2=O)c1F
Show InChI InChI=1S/C29H36F2N6O5/c1-6-24(38)33-14-20-11-21-19(13-32-20)16-37(27-25(30)22(41-4)12-23(42-5)26(27)31)29(40)36(21)15-18-7-9-35(10-8-18)28(39)34-17(2)3/h6,11-13,17-18H,1,7-10,14-16H2,2-5H3,(H,33,38)(H,34,39)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357731
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-(me...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)S(C)(=O)=O)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O6S/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(38-2)11-21(39-3)24(25)28)26(35)32(19)14-16-6-8-31(9-7-16)40(4,36)37/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357705
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3,3-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC(F)(F)C3)C2=O)c1F
Show InChI InChI=1S/C23H22F4N4O4/c1-4-18(32)29-10-13-5-15-12(9-28-13)11-30(22(33)31(15)14-7-23(26,27)8-14)21-19(24)16(34-2)6-17(35-3)20(21)25/h4-6,9,14H,1,7-8,10-11H2,2-3H3,(H,29,32)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357708
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES CCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-5-7-27-15-8-14(11-26-18(29)6-2)25-10-13(15)12-28(22(27)30)21-19(23)16(31-3)9-17(32-4)20(21)24/h6,8-10H,2,5,7,11-12H2,1,3-4H3,(H,26,29)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357713
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccnc3)C2=O)c1F
Show InChI InChI=1S/C25H23F2N5O4/c1-4-21(33)30-12-17-8-18-16(11-29-17)14-32(25(34)31(18)13-15-6-5-7-28-10-15)24-22(26)19(35-2)9-20(36-3)23(24)27/h4-11H,1,12-14H2,2-3H3,(H,30,33)
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357720
PNG
(N-((7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C22H23F2N3O4/c1-6-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14,2)3)20-18(23)15(30-4)8-16(31-5)19(20)24/h6-9H,1,10-11H2,2-5H3,(H,26,28)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357722
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccncc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-12-15-9-17-14(11-28-15)13-30(24(33)31(17)16-5-7-27-8-6-16)23-21(25)18(34-2)10-19(35-3)22(23)26/h4-11H,1,12-13H2,2-3H3,(H,29,32)
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357727
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@@H]3CCOC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/m0/s1
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357728
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(C)CC3)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O4/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(36-3)11-21(37-4)24(25)28)26(35)32(19)14-16-6-8-31(2)9-7-16/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357731
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-(me...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)S(C)(=O)=O)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O6S/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(38-2)11-21(39-3)24(25)28)26(35)32(19)14-16-6-8-31(9-7-16)40(4,36)37/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357732
PNG
(N-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C21H22Cl2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357733
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)c(C)c3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H23F2N3O4/c1-5-17(29)27-10-14-12(2)18-13(9-26-14)11-28(22(30)23(18)6-7-23)21-19(24)15(31-3)8-16(32-4)20(21)25/h5,8-9H,1,6-7,10-11H2,2-4H3,(H,27,29)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357733
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)c(C)c3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H23F2N3O4/c1-5-17(29)27-10-14-12(2)18-13(9-26-14)11-28(22(30)23(18)6-7-23)21-19(24)15(31-3)8-16(32-4)20(21)25/h5,8-9H,1,6-7,10-11H2,2-4H3,(H,27,29)
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357698
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C21H22F2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357698
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C21H22F2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357700
PNG
(N-((6′-(2,6-difluoro-3,5-dimethoxyphenyl)-7&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C21H20F2N4O4/c1-4-15(28)25-9-14-24-8-11-10-27(20(29)21(5-6-21)19(11)26-14)18-16(22)12(30-2)7-13(31-3)17(18)23/h4,7-8H,1,5-6,9-10H2,2-3H3,(H,25,28)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357700
PNG
(N-((6′-(2,6-difluoro-3,5-dimethoxyphenyl)-7&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C21H20F2N4O4/c1-4-15(28)25-9-14-24-8-11-10-27(20(29)21(5-6-21)19(11)26-14)18-16(22)12(30-2)7-13(31-3)17(18)23/h4,7-8H,1,5-6,9-10H2,2-3H3,(H,25,28)
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357701
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H25F2N3O4/c1-4-19(30)28-12-15-9-16-14(11-27-15)13-29(23(31)24(16)7-5-6-8-24)22-20(25)17(32-2)10-18(33-3)21(22)26/h4,9-11H,1,5-8,12-13H2,2-3H3,(H,28,30)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357702
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccccc2)c1F
Show InChI InChI=1S/C25H22F2N4O4/c1-4-21(32)29-13-16-10-18-15(12-28-16)14-30(25(33)31(18)17-8-6-5-7-9-17)24-22(26)19(34-2)11-20(35-3)23(24)27/h4-12H,1,13-14H2,2-3H3,(H,29,32)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357704
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N([C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O5/c1-4-19(30)27-10-14-7-16-13(9-26-14)11-28(23(31)29(16)15-5-6-34-12-15)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,15H,1,5-6,10-12H2,2-3H3,(H,27,30)/t15-/m0/s1
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357707
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-meth...)
Show SMILES COCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O5/c1-5-18(29)26-11-14-8-15-13(10-25-14)12-28(22(30)27(15)6-7-31-2)21-19(23)16(32-3)9-17(33-4)20(21)24/h5,8-10H,1,6-7,11-12H2,2-4H3,(H,26,29)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357707
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-meth...)
Show SMILES COCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O5/c1-5-18(29)26-11-14-8-15-13(10-25-14)12-28(22(30)27(15)6-7-31-2)21-19(23)16(32-3)9-17(33-4)20(21)24/h5,8-10H,1,6-7,11-12H2,2-4H3,(H,26,29)
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357709
PNG
(N-((1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13-5-6-13)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,13H,1,5-6,10-12H2,2-3H3,(H,27,30)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357710
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2,2-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)F)C2=O)c1F
Show InChI InChI=1S/C21H20F4N4O4/c1-4-17(30)27-8-12-5-13-11(7-26-12)9-29(21(31)28(13)10-16(22)23)20-18(24)14(32-2)6-15(33-3)19(20)25/h4-7,16H,1,8-10H2,2-3H3,(H,27,30)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357710
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2,2-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)F)C2=O)c1F
Show InChI InChI=1S/C21H20F4N4O4/c1-4-17(30)27-8-12-5-13-11(7-26-12)9-29(21(31)28(13)10-16(22)23)20-18(24)14(32-2)6-15(33-3)19(20)25/h4-7,16H,1,8-10H2,2-3H3,(H,27,30)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357711
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isoprop...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C(C)C)C2=O)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-6-18(29)26-10-14-7-15-13(9-25-14)11-27(22(30)28(15)12(2)3)21-19(23)16(31-4)8-17(32-5)20(21)24/h6-9,12H,1,10-11H2,2-5H3,(H,26,29)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357717
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)(F)F)C2=O)c1F
Show InChI InChI=1S/C21H19F5N4O4/c1-4-16(31)28-8-12-5-13-11(7-27-12)9-29(20(32)30(13)10-21(24,25)26)19-17(22)14(33-2)6-15(34-3)18(19)23/h4-7H,1,8-10H2,2-3H3,(H,28,31)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357720
PNG
(N-((7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C22H23F2N3O4/c1-6-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14,2)3)20-18(23)15(30-4)8-16(31-5)19(20)24/h6-9H,1,10-11H2,2-5H3,(H,26,28)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357733
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)c(C)c3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H23F2N3O4/c1-5-17(29)27-10-14-12(2)18-13(9-26-14)11-28(22(30)23(18)6-7-23)21-19(24)15(31-3)8-16(32-4)20(21)25/h5,8-9H,1,6-7,10-11H2,2-4H3,(H,27,29)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357699
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2cccnc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-11-15-8-17-14(10-28-15)13-30(24(33)31(17)16-6-5-7-27-12-16)23-21(25)18(34-2)9-19(35-3)22(23)26/h4-10,12H,1,11,13H2,2-3H3,(H,29,32)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357704
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N([C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O5/c1-4-19(30)27-10-14-7-16-13(9-26-14)11-28(23(31)29(16)15-5-6-34-12-15)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,15H,1,5-6,10-12H2,2-3H3,(H,27,30)/t15-/m0/s1
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357705
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3,3-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC(F)(F)C3)C2=O)c1F
Show InChI InChI=1S/C23H22F4N4O4/c1-4-18(32)29-10-13-5-15-12(9-28-13)11-30(22(33)31(15)14-7-23(26,27)8-14)21-19(24)16(34-2)6-17(35-3)20(21)25/h4-6,9,14H,1,7-8,10-11H2,2-3H3,(H,29,32)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357707
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-meth...)
Show SMILES COCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O5/c1-5-18(29)26-11-14-8-15-13(10-25-14)12-28(22(30)27(15)6-7-31-2)21-19(23)16(32-3)9-17(33-4)20(21)24/h5,8-10H,1,6-7,11-12H2,2-4H3,(H,26,29)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357711
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isoprop...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C(C)C)C2=O)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-6-18(29)26-10-14-7-15-13(9-25-14)11-27(22(30)28(15)12(2)3)21-19(23)16(31-4)8-17(32-5)20(21)24/h6-9,12H,1,10-11H2,2-5H3,(H,26,29)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357715
PNG
((R)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/m1/s1
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357717
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)(F)F)C2=O)c1F
Show InChI InChI=1S/C21H19F5N4O4/c1-4-16(31)28-8-12-5-13-11(7-27-12)9-29(20(32)30(13)10-21(24,25)26)19-17(22)14(33-2)6-15(34-3)18(19)23/h4-7H,1,8-10H2,2-3H3,(H,28,31)
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357723
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CCF)C2=O)c1F
Show InChI InChI=1S/C21H21F3N4O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-22)20-18(23)15(31-2)8-16(32-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,29)
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TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357726
PNG
(N-((1-(cyclobutylmethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-11-16-8-17-15(10-27-16)13-30(24(32)29(17)12-14-6-5-7-14)23-21(25)18(33-2)9-19(34-3)22(23)26/h4,8-10,14H,1,5-7,11-13H2,2-3H3,(H,28,31)
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n/an/a>200n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357730
PNG
(4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)C(=O)NC(C)C)C2=O)c1F
Show InChI InChI=1S/C29H36F2N6O5/c1-6-24(38)33-14-20-11-21-19(13-32-20)16-37(27-25(30)22(41-4)12-23(42-5)26(27)31)29(40)36(21)15-18-7-9-35(10-8-18)28(39)34-17(2)3/h6,11-13,17-18H,1,7-10,14-16H2,2-5H3,(H,33,38)(H,34,39)
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Assay Description
TBD


US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357703
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(1-meth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(c3ccn(C)n3)C2=O)c1F
Show InChI InChI=1S/C23H22F2N6O4/c1-5-19(32)27-11-14-8-15-13(10-26-14)12-30(23(33)31(15)18-6-7-29(2)28-18)22-20(24)16(34-3)9-17(35-4)21(22)25/h5-10H,1,11-12H2,2-4H3,(H,27,32)
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Assay Description
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM357708
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES CCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-5-7-27-15-8-14(11-26-18(29)6-2)25-10-13(15)12-28(22(27)30)21-19(23)16(31-3)9-17(32-4)20(21)24/h6,8-10H,2,5,7,11-12H2,1,3-4H3,(H,26,29)
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US Patent US10214528 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%