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Patent code US10214530

Compile Data Set for Download or QSAR
Found 118 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357737
PNG
(KM-05-166/(I-206) | US10214530, Example 24)
Show SMILES CCn1c2nc(Cc3nc4cc5OCOc5cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C23H20N6O4/c1-2-28-21-20(22(30)27-23(28)31)29(11-13-6-4-3-5-7-13)19(26-21)10-18-24-14-8-16-17(33-12-32-16)9-15(14)25-18/h3-9H,2,10-12H2,1H3,(H,24,25)(H,27,30,31)
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n/an/a 14n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357735
PNG
(KM-05-193/(I-209) | US10214530, Example 27)
Show SMILES CCCn1c2nc(Cc3nc4cc5OCOc5cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H22N6O4/c1-2-8-29-22-21(23(31)28-24(29)32)30(12-14-6-4-3-5-7-14)20(27-22)11-19-25-15-9-17-18(34-13-33-17)10-16(15)26-19/h3-7,9-10H,2,8,11-13H2,1H3,(H,25,26)(H,28,31,32)
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n/an/a 14n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357734
PNG
(KM-05-185/(I-204) | US10214530, Example 21)
Show SMILES CCCn1c2nc(Cc3nc4ccc(O)cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C23H22N6O3/c1-2-10-28-21-20(22(31)27-23(28)32)29(13-14-6-4-3-5-7-14)19(26-21)12-18-24-16-9-8-15(30)11-17(16)25-18/h3-9,11,30H,2,10,12-13H2,1H3,(H,24,25)(H,27,31,32)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357739
PNG
(AG-01-128/(I-202) | US10214530, Example 18)
Show SMILES CCn1c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H20N6O2/c1-2-27-20-19(21(29)26-22(27)30)28(13-14-8-4-3-5-9-14)18(25-20)12-17-23-15-10-6-7-11-16(15)24-17/h3-11H,2,12-13H2,1H3,(H,23,24)(H,26,29,30)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357736
PNG
(MW-01-157/(I-207) | US10214530, Example 25)
Show SMILES CCCn1c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C23H22N6O2/c1-2-12-28-21-20(22(30)27-23(28)31)29(14-15-8-4-3-5-9-15)19(26-21)13-18-24-16-10-6-7-11-17(16)25-18/h3-11H,2,12-14H2,1H3,(H,24,25)(H,27,30,31)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357743
PNG
(MW-01-139/(I-46) | US10214530, Example 52)
Show SMILES CCn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H18N6O2S/c1-2-26-17-16(18(28)25-20(26)29)27(12-13-8-4-3-5-9-13)21(24-17)30-19-22-14-10-6-7-11-15(14)23-19/h3-11H,2,12H2,1H3,(H,22,23)(H,25,28,29)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357790
PNG
(KM-05-179/(I-201) | US10214530, Example 14)
Show SMILES CCOc1ccc2nc(Cc3nc4n(CC)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C24H24N6O3/c1-3-29-22-21(23(31)28-24(29)32)30(14-15-8-6-5-7-9-15)20(27-22)13-19-25-17-11-10-16(33-4-2)12-18(17)26-19/h5-12H,3-4,13-14H2,1-2H3,(H,25,26)(H,28,31,32)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357740
PNG
(KM-05-139/(I-23) | US10214530, Example 23)
Show SMILES O=c1[nH]c(=O)c2n(Cc3ccccc3)c(Cc3nc4cc5OCOc5cc4[nH]3)nc2n1C1CC1
Show InChI InChI=1S/C24H20N6O4/c31-23-21-22(30(14-6-7-14)24(32)28-23)27-20(29(21)11-13-4-2-1-3-5-13)10-19-25-15-8-17-18(34-12-33-17)9-16(15)26-19/h1-5,8-9,14H,6-7,10-12H2,(H,25,26)(H,28,31,32)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357747
PNG
(KM-05-173/(I-203) | US10214530, Example 20)
Show SMILES CCn1c2nc(Cc3nc4cc(F)c(cc4[nH]3)N(C)C)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H24FN7O2/c1-4-31-22-21(23(33)29-24(31)34)32(13-14-8-6-5-7-9-14)20(28-22)12-19-26-16-10-15(25)18(30(2)3)11-17(16)27-19/h5-11H,4,12-13H2,1-3H3,(H,26,27)(H,29,33,34)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357741
PNG
(MW-01-153/(I-47) | US10214530, Example 53)
Show SMILES CCCn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H20N6O2S/c1-2-12-27-18-17(19(29)26-21(27)30)28(13-14-8-4-3-5-9-14)22(25-18)31-20-23-15-10-6-7-11-16(15)24-20/h3-11H,2,12-13H2,1H3,(H,23,24)(H,26,29,30)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357738
PNG
(KM-05-130/(I-19) | US10214530, Example 19)
Show SMILES Oc1ccc2nc(Cc3nc4n(C5CC5)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C23H20N6O3/c30-15-8-9-16-17(10-15)25-18(24-16)11-19-26-21-20(28(19)12-13-4-2-1-3-5-13)22(31)27-23(32)29(21)14-6-7-14/h1-5,8-10,14,30H,6-7,11-12H2,(H,24,25)(H,27,31,32)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357753
PNG
(KM-05-174/(I-205) | US10214530, Example 22)
Show SMILES CCn1c2nc(Cc3nc4cc(F)c(cc4[nH]3)N3CCOCC3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C26H26FN7O3/c1-2-33-24-23(25(35)31-26(33)36)34(15-16-6-4-3-5-7-16)22(30-24)14-21-28-18-12-17(27)20(13-19(18)29-21)32-8-10-37-11-9-32/h3-7,12-13H,2,8-11,14-15H2,1H3,(H,28,29)(H,31,35,36)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357745
PNG
(KM-05-125/(I-13) | US10214530, Example 13)
Show SMILES COc1ccc2nc(Cc3nc4n(C5CC5)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C24H22N6O3/c1-33-16-9-10-17-18(11-16)26-19(25-17)12-20-27-22-21(29(20)13-14-5-3-2-4-6-14)23(31)28-24(32)30(22)15-7-8-15/h2-6,9-11,15H,7-8,12-13H2,1H3,(H,25,26)(H,28,31,32)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357744
PNG
(KM-05-80/(I-1) | US10214530, Example 1)
Show SMILES O=c1[nH]c(=O)c2n(Cc3ccccc3)c(Cc3nc4ccccc4[nH]3)nc2n1C1CC1
Show InChI InChI=1S/C23H20N6O2/c30-22-20-21(29(15-10-11-15)23(31)27-22)26-19(28(20)13-14-6-2-1-3-7-14)12-18-24-16-8-4-5-9-17(16)25-18/h1-9,15H,10-13H2,(H,24,25)(H,27,30,31)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357749
PNG
(KM-06-11/(I-210) | US10214530, Example 28)
Show SMILES CCn1c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccc(F)cc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H19FN6O2/c1-2-28-20-19(21(30)27-22(28)31)29(12-13-7-9-14(23)10-8-13)18(26-20)11-17-24-15-5-3-4-6-16(15)25-17/h3-10H,2,11-12H2,1H3,(H,24,25)(H,27,30,31)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357746
PNG
(KM-06-20/(I-211) | US10214530, Example 29)
Show SMILES CCn1c2nc(Cc3nc4ccc(cc4[nH]3)-c3cc[nH]n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H22N8O2/c1-2-32-23-22(24(34)30-25(32)35)33(14-15-6-4-3-5-7-15)21(29-23)13-20-27-18-9-8-16(12-19(18)28-20)17-10-11-26-31-17/h3-12H,2,13-14H2,1H3,(H,26,31)(H,27,28)(H,30,34,35)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357748
PNG
(KM-05-89/(I-2) | US10214530, Example 2)
Show SMILES O=c1[nH]c(=O)c2n(Cc3ccccc3)c(Cc3nc4cc(ccc4[nH]3)N3CCOCC3)nc2n1C1CC1
Show InChI InChI=1S/C27H27N7O3/c35-26-24-25(34(18-6-7-18)27(36)31-26)30-23(33(24)16-17-4-2-1-3-5-17)15-22-28-20-9-8-19(14-21(20)29-22)32-10-12-37-13-11-32/h1-5,8-9,14,18H,6-7,10-13,15-16H2,(H,28,29)(H,31,35,36)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357751
PNG
(KM-05-128/(I-17) | US10214530, Example 17)
Show SMILES COC(=O)c1ccc2nc(Cc3nc4n(C5CC5)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C25H22N6O4/c1-35-24(33)15-7-10-17-18(11-15)27-19(26-17)12-20-28-22-21(30(20)13-14-5-3-2-4-6-14)23(32)29-25(34)31(22)16-8-9-16/h2-7,10-11,16H,8-9,12-13H2,1H3,(H,26,27)(H,29,32,34)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357750
PNG
(KM-05-135/(I-15) | US10214530, Example 15)
Show SMILES OCCOc1ccc2nc(Cc3nc4n(C5CC5)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C25H24N6O4/c32-10-11-35-17-8-9-18-19(12-17)27-20(26-18)13-21-28-23-22(30(21)14-15-4-2-1-3-5-15)24(33)29-25(34)31(23)16-6-7-16/h1-5,8-9,12,16,32H,6-7,10-11,13-14H2,(H,26,27)(H,29,33,34)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357754
PNG
(KM-05-60/(I-10) | US10214530, Example 10)
Show SMILES Cn1c2nc(Cc3nc4cc(NC(=O)CC[C@H](N)C(O)=O)ccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C26H26N8O5/c1-33-23-22(24(36)32-26(33)39)34(13-14-5-3-2-4-6-14)20(31-23)12-19-29-17-9-7-15(11-18(17)30-19)28-21(35)10-8-16(27)25(37)38/h2-7,9,11,16H,8,10,12-13,27H2,1H3,(H,28,35)(H,29,30)(H,37,38)(H,32,36,39)/t16-/m0/s1
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357760
PNG
(KM-05-50/(I-4) | US10214530, Example 4)
Show SMILES Cn1c2nc(Cc3nc4cc(ccc4[nH]3)N3CCOCC3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H25N7O3/c1-30-23-22(24(33)29-25(30)34)32(15-16-5-3-2-4-6-16)21(28-23)14-20-26-18-8-7-17(13-19(18)27-20)31-9-11-35-12-10-31/h2-8,13H,9-12,14-15H2,1H3,(H,26,27)(H,29,33,34)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357755
PNG
(KM-05-93/(I-9) | US10214530, Example 9)
Show SMILES O=c1[nH]c(=O)c2n(Cc3ccccc3)c(Cc3nc4cc(ccc4[nH]3)N3CCNCC3)nc2n1C1CC1
Show InChI InChI=1S/C27H28N8O2/c36-26-24-25(35(18-6-7-18)27(37)32-26)31-23(34(24)16-17-4-2-1-3-5-17)15-22-29-20-9-8-19(14-21(20)30-22)33-12-10-28-11-13-33/h1-5,8-9,14,18,28H,6-7,10-13,15-16H2,(H,29,30)(H,32,36,37)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357756
PNG
(KM480/(I-41) | US10214530, Example 47)
Show SMILES Cn1c2nc(Sc3nc4cc(NC(=O)CC[C@H](N)C(O)=O)ccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H24N8O5S/c1-32-20-19(21(35)31-24(32)38)33(12-13-5-3-2-4-6-13)25(30-20)39-23-28-16-9-7-14(11-17(16)29-23)27-18(34)10-8-15(26)22(36)37/h2-7,9,11,15H,8,10,12,26H2,1H3,(H,27,34)(H,28,29)(H,36,37)(H,31,35,38)/t15-/m0/s1
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357752
PNG
(KM-05-126/(I-12) | US10214530, Example 12)
Show SMILES Fc1ccc2nc(Cc3nc4n(C5CC5)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C23H19FN6O2/c24-14-6-9-16-17(10-14)26-18(25-16)11-19-27-21-20(29(19)12-13-4-2-1-3-5-13)22(31)28-23(32)30(21)15-7-8-15/h1-6,9-10,15H,7-8,11-12H2,(H,25,26)(H,28,31,32)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357734
PNG
(KM-05-185/(I-204) | US10214530, Example 21)
Show SMILES CCCn1c2nc(Cc3nc4ccc(O)cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C23H22N6O3/c1-2-10-28-21-20(22(31)27-23(28)32)29(13-14-6-4-3-5-7-14)19(26-21)12-18-24-16-9-8-15(30)11-17(16)25-18/h3-9,11,30H,2,10,12-13H2,1H3,(H,24,25)(H,27,31,32)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357757
PNG
(KM-05-55 Fr16-17/(I-7) | US10214530, Example 7)
Show SMILES CC(=O)Nc1ccc2nc(Cc3nc4n(C)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C23H21N7O3/c1-13(31)24-15-8-9-16-17(10-15)26-18(25-16)11-19-27-21-20(22(32)28-23(33)29(21)2)30(19)12-14-6-4-3-5-7-14/h3-10H,11-12H2,1-2H3,(H,24,31)(H,25,26)(H,28,32,33)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357735
PNG
(KM-05-193/(I-209) | US10214530, Example 27)
Show SMILES CCCn1c2nc(Cc3nc4cc5OCOc5cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H22N6O4/c1-2-8-29-22-21(23(31)28-24(29)32)30(12-14-6-4-3-5-7-14)20(27-22)11-19-25-15-9-17-18(34-13-33-17)10-16(15)26-19/h3-7,9-10H,2,8,11-13H2,1H3,(H,25,26)(H,28,31,32)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357736
PNG
(MW-01-157/(I-207) | US10214530, Example 25)
Show SMILES CCCn1c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C23H22N6O2/c1-2-12-28-21-20(22(30)27-23(28)31)29(14-15-8-4-3-5-9-15)19(26-21)13-18-24-16-10-6-7-11-17(16)25-18/h3-11H,2,12-14H2,1H3,(H,24,25)(H,27,30,31)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357737
PNG
(KM-05-166/(I-206) | US10214530, Example 24)
Show SMILES CCn1c2nc(Cc3nc4cc5OCOc5cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C23H20N6O4/c1-2-28-21-20(22(30)27-23(28)31)29(11-13-6-4-3-5-7-13)19(26-21)10-18-24-14-8-16-17(33-12-32-16)9-15(14)25-18/h3-9H,2,10-12H2,1H3,(H,24,25)(H,27,30,31)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357738
PNG
(KM-05-130/(I-19) | US10214530, Example 19)
Show SMILES Oc1ccc2nc(Cc3nc4n(C5CC5)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C23H20N6O3/c30-15-8-9-16-17(10-15)25-18(24-16)11-19-26-21-20(28(19)12-13-4-2-1-3-5-13)22(31)27-23(32)29(21)14-6-7-14/h1-5,8-10,14,30H,6-7,11-12H2,(H,24,25)(H,27,31,32)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357739
PNG
(AG-01-128/(I-202) | US10214530, Example 18)
Show SMILES CCn1c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H20N6O2/c1-2-27-20-19(21(29)26-22(27)30)28(13-14-8-4-3-5-9-14)18(25-20)12-17-23-15-10-6-7-11-16(15)24-17/h3-11H,2,12-13H2,1H3,(H,23,24)(H,26,29,30)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357765
PNG
(KM422/(I-25) | US10214530, Example 31)
Show SMILES COc1ccc2[nH]c(Sc3nc4n(C)c(=O)[nH]c(=O)c4n3Cc3ccccc3)nc2c1
Show InChI InChI=1S/C21H18N6O3S/c1-26-17-16(18(28)25-20(26)29)27(11-12-6-4-3-5-7-12)21(24-17)31-19-22-14-9-8-13(30-2)10-15(14)23-19/h3-10H,11H2,1-2H3,(H,22,23)(H,25,28,29)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357759
PNG
(KM-05-127/(I-16) | US10214530, Example 16)
Show SMILES O=c1[nH]c(=O)c2n(Cc3ccccc3)c(Cc3nc4ccc(cc4[nH]3)C#N)nc2n1C1CC1
Show InChI InChI=1S/C24H19N7O2/c25-12-15-6-9-17-18(10-15)27-19(26-17)11-20-28-22-21(30(20)13-14-4-2-1-3-5-14)23(32)29-24(33)31(22)16-7-8-16/h1-6,9-10,16H,7-8,11,13H2,(H,26,27)(H,29,32,33)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357762
PNG
(KM430/(I-31) | US10214530, Example 37)
Show SMILES Cn1c2nc(Sc3nc4cc(N)ccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H17N7O2S/c1-26-16-15(17(28)25-19(26)29)27(10-11-5-3-2-4-6-11)20(24-16)30-18-22-13-8-7-12(21)9-14(13)23-18/h2-9H,10,21H2,1H3,(H,22,23)(H,25,28,29)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357769
PNG
(KM446/(I-35) | US10214530, Example 41)
Show SMILES Cc1ccc2[nH]c(Sc3nc4n(C)c(=O)[nH]c(=O)c4n3Cc3cncs3)nc2c1
Show InChI InChI=1S/C18H15N7O2S2/c1-9-3-4-11-12(5-9)21-16(20-11)29-18-22-14-13(15(26)23-17(27)24(14)2)25(18)7-10-6-19-8-28-10/h3-6,8H,7H2,1-2H3,(H,20,21)(H,23,26,27)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357770
PNG
(KM424/(I-27) | US10214530, Example 33)
Show SMILES Cc1ccc2[nH]c(Sc3nc4n(C)c(=O)[nH]c(=O)c4n3Cc3ccccc3)nc2c1
Show InChI InChI=1S/C21H18N6O2S/c1-12-8-9-14-15(10-12)23-19(22-14)30-21-24-17-16(18(28)25-20(29)26(17)2)27(21)11-13-6-4-3-5-7-13/h3-10H,11H2,1-2H3,(H,22,23)(H,25,28,29)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357740
PNG
(KM-05-139/(I-23) | US10214530, Example 23)
Show SMILES O=c1[nH]c(=O)c2n(Cc3ccccc3)c(Cc3nc4cc5OCOc5cc4[nH]3)nc2n1C1CC1
Show InChI InChI=1S/C24H20N6O4/c31-23-21-22(30(14-6-7-14)24(32)28-23)27-20(29(21)11-13-4-2-1-3-5-13)10-19-25-15-8-17-18(34-12-33-17)9-16(15)26-19/h1-5,8-9,14H,6-7,10-12H2,(H,25,26)(H,28,31,32)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357761
PNG
(KM-05-55 Fr10-12/(l-6) | US10214530, Example 6)
Show SMILES Cn1c2nc(Cc3nc4ccc(N)cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H19N7O2/c1-27-19-18(20(29)26-21(27)30)28(11-12-5-3-2-4-6-12)17(25-19)10-16-23-14-8-7-13(22)9-15(14)24-16/h2-9H,10-11,22H2,1H3,(H,23,24)(H,26,29,30)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357742
PNG
(US10214530, LX1031)
Show SMILES COc1cccc(c1)-c1ccc(cc1)[C@@H](Oc1cc(nc(N)n1)-c1ccc(CC(N)C(O)=O)cc1)C(F)(F)F
Show InChI InChI=1S/C28H25F3N4O4/c1-38-21-4-2-3-20(14-21)17-9-11-19(12-10-17)25(28(29,30)31)39-24-15-23(34-27(33)35-24)18-7-5-16(6-8-18)13-22(32)26(36)37/h2-12,14-15,22,25H,13,32H2,1H3,(H,36,37)(H2,33,34,35)/t22?,25-/m1/s1
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n/an/a 730n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357758
PNG
(KM-05-100/(I-11) | US10214530, Example 11)
Show SMILES Cn1c2nc(Cc3nc4ccc(Br)cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H17BrN6O2/c1-27-19-18(20(29)26-21(27)30)28(11-12-5-3-2-4-6-12)17(25-19)10-16-23-14-8-7-13(22)9-15(14)24-16/h2-9H,10-11H2,1H3,(H,23,24)(H,26,29,30)
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n/an/a 740n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357741
PNG
(MW-01-153/(I-47) | US10214530, Example 53)
Show SMILES CCCn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H20N6O2S/c1-2-12-27-18-17(19(29)26-21(27)30)28(13-14-8-4-3-5-9-14)22(25-18)31-20-23-15-10-6-7-11-16(15)24-20/h3-11H,2,12-13H2,1H3,(H,23,24)(H,26,29,30)
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n/an/a 760n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357777
PNG
(KM-05-52/(I-5) | US10214530, Example 5)
Show SMILES CN1CCN(CC1)c1ccc2nc(Cc3nc4n(C)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C26H28N8O2/c1-31-10-12-33(13-11-31)18-8-9-19-20(14-18)28-21(27-19)15-22-29-24-23(25(35)30-26(36)32(24)2)34(22)16-17-6-4-3-5-7-17/h3-9,14H,10-13,15-16H2,1-2H3,(H,27,28)(H,30,35,36)
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n/an/a 760n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357742
PNG
(US10214530, LX1031)
Show SMILES COc1cccc(c1)-c1ccc(cc1)[C@@H](Oc1cc(nc(N)n1)-c1ccc(CC(N)C(O)=O)cc1)C(F)(F)F
Show InChI InChI=1S/C28H25F3N4O4/c1-38-21-4-2-3-20(14-21)17-9-11-19(12-10-17)25(28(29,30)31)39-24-15-23(34-27(33)35-24)18-7-5-16(6-8-18)13-22(32)26(36)37/h2-12,14-15,22,25H,13,32H2,1H3,(H,36,37)(H2,33,34,35)/t22?,25-/m1/s1
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n/an/a 770n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357763
PNG
(KM-05-16/(I-3) | US10214530, Example 3)
Show SMILES Cn1c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H18N6O2/c1-26-19-18(20(28)25-21(26)29)27(12-13-7-3-2-4-8-13)17(24-19)11-16-22-14-9-5-6-10-15(14)23-16/h2-10H,11-12H2,1H3,(H,22,23)(H,25,28,29)
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n/an/a 820n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357766
PNG
(KM477/(I-40) | US10214530, Example 46)
Show SMILES Cn1c2nc(Sc3nc4cc(NC(=O)C[C@H](N)C(O)=O)ccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H22N8O5S/c1-31-19-18(20(34)30-23(31)37)32(11-12-5-3-2-4-6-12)24(29-19)38-22-27-15-8-7-13(9-16(15)28-22)26-17(33)10-14(25)21(35)36/h2-9,14H,10-11,25H2,1H3,(H,26,33)(H,27,28)(H,35,36)(H,30,34,37)/t14-/m0/s1
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n/an/a 830n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357743
PNG
(MW-01-139/(I-46) | US10214530, Example 52)
Show SMILES CCn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H18N6O2S/c1-2-26-17-16(18(28)25-20(26)29)27(12-13-8-4-3-5-9-13)21(24-17)30-19-22-14-10-6-7-11-15(14)23-19/h3-11H,2,12H2,1H3,(H,22,23)(H,25,28,29)
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n/an/a 830n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357771
PNG
(KM-05-180/(I-208) | US10214530, Example 26)
Show SMILES CCn1c2nc(Cc3nc4ncccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H19N7O2/c1-2-27-19-17(20(29)26-21(27)30)28(12-13-7-4-3-5-8-13)16(25-19)11-15-23-14-9-6-10-22-18(14)24-15/h3-10H,2,11-12H2,1H3,(H,22,23,24)(H,26,29,30)
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n/an/a 850n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357744
PNG
(KM-05-80/(I-1) | US10214530, Example 1)
Show SMILES O=c1[nH]c(=O)c2n(Cc3ccccc3)c(Cc3nc4ccccc4[nH]3)nc2n1C1CC1
Show InChI InChI=1S/C23H20N6O2/c30-22-20-21(29(15-10-11-15)23(31)27-22)26-19(28(20)13-14-6-2-1-3-7-14)12-18-24-16-8-4-5-9-17(16)25-18/h1-9,15H,10-13H2,(H,24,25)(H,27,30,31)
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n/an/a 850n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357772
PNG
(KM447/(I-36) | US10214530, Example 42)
Show SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3nccs3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C17H13N7O2S2/c1-23-13-12(14(25)22-16(23)26)24(8-11-18-6-7-27-11)17(21-13)28-15-19-9-4-2-3-5-10(9)20-15/h2-7H,8H2,1H3,(H,19,20)(H,22,25,26)
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n/an/a 900n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357764
PNG
(KM406/(I-24) | US10214530, Example 30)
Show SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H16N6O2S/c1-25-16-15(17(27)24-19(25)28)26(11-12-7-3-2-4-8-12)20(23-16)29-18-21-13-9-5-6-10-14(13)22-18/h2-10H,11H2,1H3,(H,21,22)(H,24,27,28)
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n/an/a 920n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357745
PNG
(KM-05-125/(I-13) | US10214530, Example 13)
Show SMILES COc1ccc2nc(Cc3nc4n(C5CC5)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C24H22N6O3/c1-33-16-9-10-17-18(11-16)26-19(25-17)12-20-27-22-21(29(20)13-14-5-3-2-4-6-14)23(31)28-24(32)30(22)15-7-8-15/h2-6,9-11,15H,7-8,12-13H2,1H3,(H,25,26)(H,28,31,32)
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n/an/a 960n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357746
PNG
(KM-06-20/(I-211) | US10214530, Example 29)
Show SMILES CCn1c2nc(Cc3nc4ccc(cc4[nH]3)-c3cc[nH]n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H22N8O2/c1-2-32-23-22(24(34)30-25(32)35)33(14-15-6-4-3-5-7-15)21(29-23)13-20-27-18-9-8-16(12-19(18)28-20)17-10-11-26-31-17/h3-12H,2,13-14H2,1H3,(H,26,31)(H,27,28)(H,30,34,35)
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n/an/a 1.07E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357767
PNG
(KM-05-68/(I-8) | US10214530, Example 8)
Show SMILES Cn1c2nc(Cc3nc4ccc(cc4[nH]3)N3CCC(CC3)C(O)=O)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C27H27N7O4/c1-32-24-23(25(35)31-27(32)38)34(15-16-5-3-2-4-6-16)22(30-24)14-21-28-19-8-7-18(13-20(19)29-21)33-11-9-17(10-12-33)26(36)37/h2-8,13,17H,9-12,14-15H2,1H3,(H,28,29)(H,36,37)(H,31,35,38)
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n/an/a 1.09E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357747
PNG
(KM-05-173/(I-203) | US10214530, Example 20)
Show SMILES CCn1c2nc(Cc3nc4cc(F)c(cc4[nH]3)N(C)C)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H24FN7O2/c1-4-31-22-21(23(33)29-24(31)34)32(13-14-8-6-5-7-9-14)20(28-22)12-19-26-16-10-15(25)18(30(2)3)11-17(16)27-19/h5-11H,4,12-13H2,1-3H3,(H,26,27)(H,29,33,34)
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n/an/a 1.21E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357773
PNG
(KM489/(I-43) | US10214530, Example 49)
Show SMILES CC(=O)Nc1ccc(Cn2c(Sc3nc4ccccc4[nH]3)nc3n(C)c(=O)[nH]c(=O)c23)cc1
Show InChI InChI=1S/C22H19N7O3S/c1-12(30)23-14-9-7-13(8-10-14)11-29-17-18(28(2)21(32)27-19(17)31)26-22(29)33-20-24-15-5-3-4-6-16(15)25-20/h3-10H,11H2,1-2H3,(H,23,30)(H,24,25)(H,27,31,32)
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n/an/a 1.24E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357776
PNG
(KM483/(I-42) | US10214530, Example 48)
Show SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccc(cc3)N3CCOCC3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H23N7O3S/c1-29-20-19(21(32)28-23(29)33)31(14-15-6-8-16(9-7-15)30-10-12-34-13-11-30)24(27-20)35-22-25-17-4-2-3-5-18(17)26-22/h2-9H,10-14H2,1H3,(H,25,26)(H,28,32,33)
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n/an/a 1.33E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357748
PNG
(KM-05-89/(I-2) | US10214530, Example 2)
Show SMILES O=c1[nH]c(=O)c2n(Cc3ccccc3)c(Cc3nc4cc(ccc4[nH]3)N3CCOCC3)nc2n1C1CC1
Show InChI InChI=1S/C27H27N7O3/c35-26-24-25(34(18-6-7-18)27(36)31-26)30-23(33(24)16-17-4-2-1-3-5-17)15-22-28-20-9-8-19(14-21(20)29-22)32-10-12-37-13-11-32/h1-5,8-9,14,18H,6-7,10-13,15-16H2,(H,28,29)(H,31,35,36)
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n/an/a 1.33E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357768
PNG
(KM501/(I-45) | US10214530, Example 51)
Show SMILES Cn1c2nc(Sc3nc4cc(NCC(O)=O)ccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H19N7O4S/c1-28-18-17(19(32)27-21(28)33)29(11-12-5-3-2-4-6-12)22(26-18)34-20-24-14-8-7-13(9-15(14)25-20)23-10-16(30)31/h2-9,23H,10-11H2,1H3,(H,24,25)(H,30,31)(H,27,32,33)
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n/an/a 1.39E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357774
PNG
(KM448/(I-37) | US10214530, Example 43)
Show SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3cnco3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C17H13N7O3S/c1-23-13-12(14(25)22-16(23)26)24(7-9-6-18-8-27-9)17(21-13)28-15-19-10-4-2-3-5-11(10)20-15/h2-6,8H,7H2,1H3,(H,19,20)(H,22,25,26)
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n/an/a 1.41E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357749
PNG
(KM-06-11/(I-210) | US10214530, Example 28)
Show SMILES CCn1c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccc(F)cc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H19FN6O2/c1-2-28-20-19(21(30)27-22(28)31)29(12-13-7-9-14(23)10-8-13)18(26-20)11-17-24-15-5-3-4-6-16(15)25-17/h3-10H,2,11-12H2,1H3,(H,24,25)(H,27,30,31)
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n/an/a 1.56E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357750
PNG
(KM-05-135/(I-15) | US10214530, Example 15)
Show SMILES OCCOc1ccc2nc(Cc3nc4n(C5CC5)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C25H24N6O4/c32-10-11-35-17-8-9-18-19(12-17)27-20(26-18)13-21-28-23-22(30(21)14-15-4-2-1-3-5-15)24(33)29-25(34)31(23)16-6-7-16/h1-5,8-9,12,16,32H,6-7,10-11,13-14H2,(H,26,27)(H,29,33,34)
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n/an/a 1.60E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357751
PNG
(KM-05-128/(I-17) | US10214530, Example 17)
Show SMILES COC(=O)c1ccc2nc(Cc3nc4n(C5CC5)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C25H22N6O4/c1-35-24(33)15-7-10-17-18(11-15)27-19(26-17)12-20-28-22-21(30(20)13-14-5-3-2-4-6-14)23(32)29-25(34)31(22)16-8-9-16/h2-7,10-11,16H,8-9,12-13H2,1H3,(H,26,27)(H,29,32,34)
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n/an/a 1.62E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357752
PNG
(KM-05-126/(I-12) | US10214530, Example 12)
Show SMILES Fc1ccc2nc(Cc3nc4n(C5CC5)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C23H19FN6O2/c24-14-6-9-16-17(10-14)26-18(25-16)11-19-27-21-20(29(19)12-13-4-2-1-3-5-13)22(31)28-23(32)30(21)15-7-8-15/h1-6,9-10,15H,7-8,11-12H2,(H,25,26)(H,28,31,32)
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n/an/a 1.80E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357753
PNG
(KM-05-174/(I-205) | US10214530, Example 22)
Show SMILES CCn1c2nc(Cc3nc4cc(F)c(cc4[nH]3)N3CCOCC3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C26H26FN7O3/c1-2-33-24-23(25(35)31-26(33)36)34(15-16-6-4-3-5-7-16)22(30-24)14-21-28-18-12-17(27)20(13-19(18)29-21)32-8-10-37-11-9-32/h3-7,12-13H,2,8-11,14-15H2,1H3,(H,28,29)(H,31,35,36)
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n/an/a 1.96E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357742
PNG
(US10214530, LX1031)
Show SMILES COc1cccc(c1)-c1ccc(cc1)[C@@H](Oc1cc(nc(N)n1)-c1ccc(CC(N)C(O)=O)cc1)C(F)(F)F
Show InChI InChI=1S/C28H25F3N4O4/c1-38-21-4-2-3-20(14-21)17-9-11-19(12-10-17)25(28(29,30)31)39-24-15-23(34-27(33)35-24)18-7-5-16(6-8-18)13-22(32)26(36)37/h2-12,14-15,22,25H,13,32H2,1H3,(H,36,37)(H2,33,34,35)/t22?,25-/m1/s1
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n/an/a 2.01E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357742
PNG
(US10214530, LX1031)
Show SMILES COc1cccc(c1)-c1ccc(cc1)[C@@H](Oc1cc(nc(N)n1)-c1ccc(CC(N)C(O)=O)cc1)C(F)(F)F
Show InChI InChI=1S/C28H25F3N4O4/c1-38-21-4-2-3-20(14-21)17-9-11-19(12-10-17)25(28(29,30)31)39-24-15-23(34-27(33)35-24)18-7-5-16(6-8-18)13-22(32)26(36)37/h2-12,14-15,22,25H,13,32H2,1H3,(H,36,37)(H2,33,34,35)/t22?,25-/m1/s1
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n/an/a 2.01E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357742
PNG
(US10214530, LX1031)
Show SMILES COc1cccc(c1)-c1ccc(cc1)[C@@H](Oc1cc(nc(N)n1)-c1ccc(CC(N)C(O)=O)cc1)C(F)(F)F
Show InChI InChI=1S/C28H25F3N4O4/c1-38-21-4-2-3-20(14-21)17-9-11-19(12-10-17)25(28(29,30)31)39-24-15-23(34-27(33)35-24)18-7-5-16(6-8-18)13-22(32)26(36)37/h2-12,14-15,22,25H,13,32H2,1H3,(H,36,37)(H2,33,34,35)/t22?,25-/m1/s1
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n/an/a 2.01E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357786
PNG
(KM450/(I-39) | US10214530, Example 45)
Show SMILES Cc1ccc2[nH]c(Sc3nc4n(C)c(=O)[nH]c(=O)c4n3Cc3ccco3)nc2c1
Show InChI InChI=1S/C19H16N6O3S/c1-10-5-6-12-13(8-10)21-17(20-12)29-19-22-15-14(16(26)23-18(27)24(15)2)25(19)9-11-4-3-7-28-11/h3-8H,9H2,1-2H3,(H,20,21)(H,23,26,27)
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n/an/a 2.06E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357754
PNG
(KM-05-60/(I-10) | US10214530, Example 10)
Show SMILES Cn1c2nc(Cc3nc4cc(NC(=O)CC[C@H](N)C(O)=O)ccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C26H26N8O5/c1-33-23-22(24(36)32-26(33)39)34(13-14-5-3-2-4-6-14)20(31-23)12-19-29-17-9-7-15(11-18(17)30-19)28-21(35)10-8-16(27)25(37)38/h2-7,9,11,16H,8,10,12-13,27H2,1H3,(H,28,35)(H,29,30)(H,37,38)(H,32,36,39)/t16-/m0/s1
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n/an/a 2.22E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357742
PNG
(US10214530, LX1031)
Show SMILES COc1cccc(c1)-c1ccc(cc1)[C@@H](Oc1cc(nc(N)n1)-c1ccc(CC(N)C(O)=O)cc1)C(F)(F)F
Show InChI InChI=1S/C28H25F3N4O4/c1-38-21-4-2-3-20(14-21)17-9-11-19(12-10-17)25(28(29,30)31)39-24-15-23(34-27(33)35-24)18-7-5-16(6-8-18)13-22(32)26(36)37/h2-12,14-15,22,25H,13,32H2,1H3,(H,36,37)(H2,33,34,35)/t22?,25-/m1/s1
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n/an/a 2.23E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357742
PNG
(US10214530, LX1031)
Show SMILES COc1cccc(c1)-c1ccc(cc1)[C@@H](Oc1cc(nc(N)n1)-c1ccc(CC(N)C(O)=O)cc1)C(F)(F)F
Show InChI InChI=1S/C28H25F3N4O4/c1-38-21-4-2-3-20(14-21)17-9-11-19(12-10-17)25(28(29,30)31)39-24-15-23(34-27(33)35-24)18-7-5-16(6-8-18)13-22(32)26(36)37/h2-12,14-15,22,25H,13,32H2,1H3,(H,36,37)(H2,33,34,35)/t22?,25-/m1/s1
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n/an/a 2.23E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357783
PNG
(KM432/(I-33) | US10214530, Example 39)
Show SMILES Cn1c2nc(Sc3nc4cccnc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C19H15N7O2S/c1-25-15-13(16(27)24-18(25)28)26(10-11-6-3-2-4-7-11)19(23-15)29-17-21-12-8-5-9-20-14(12)22-17/h2-9H,10H2,1H3,(H,20,21,22)(H,24,27,28)
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n/an/a 2.68E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357755
PNG
(KM-05-93/(I-9) | US10214530, Example 9)
Show SMILES O=c1[nH]c(=O)c2n(Cc3ccccc3)c(Cc3nc4cc(ccc4[nH]3)N3CCNCC3)nc2n1C1CC1
Show InChI InChI=1S/C27H28N8O2/c36-26-24-25(35(18-6-7-18)27(37)32-26)31-23(34(24)16-17-4-2-1-3-5-17)15-22-29-20-9-8-19(14-21(20)30-22)33-12-10-28-11-13-33/h1-5,8-9,14,18,28H,6-7,10-13,15-16H2,(H,29,30)(H,32,36,37)
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n/an/a 2.70E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357756
PNG
(KM480/(I-41) | US10214530, Example 47)
Show SMILES Cn1c2nc(Sc3nc4cc(NC(=O)CC[C@H](N)C(O)=O)ccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H24N8O5S/c1-32-20-19(21(35)31-24(32)38)33(12-13-5-3-2-4-6-13)25(30-20)39-23-28-16-9-7-14(11-17(16)29-23)27-18(34)10-8-15(26)22(36)37/h2-7,9,11,15H,8,10,12,26H2,1H3,(H,27,34)(H,28,29)(H,36,37)(H,31,35,38)/t15-/m0/s1
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n/an/a 2.95E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357785
PNG
(KM449/(I-38) | US10214530, Example 44)
Show SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccco3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C18H14N6O3S/c1-23-14-13(15(25)22-17(23)26)24(9-10-5-4-8-27-10)18(21-14)28-16-19-11-6-2-3-7-12(11)20-16/h2-8H,9H2,1H3,(H,19,20)(H,22,25,26)
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n/an/a 3.49E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357775
PNG
(KM495/(I-44) | US10214530, Example 50)
Show SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccc(N)cc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H17N7O2S/c1-26-16-15(17(28)25-19(26)29)27(10-11-6-8-12(21)9-7-11)20(24-16)30-18-22-13-4-2-3-5-14(13)23-18/h2-9H,10,21H2,1H3,(H,22,23)(H,25,28,29)
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n/an/a 4.00E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357757
PNG
(KM-05-55 Fr16-17/(I-7) | US10214530, Example 7)
Show SMILES CC(=O)Nc1ccc2nc(Cc3nc4n(C)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C23H21N7O3/c1-13(31)24-15-8-9-16-17(10-15)26-18(25-16)11-19-27-21-20(22(32)28-23(33)29(21)2)30(19)12-14-6-4-3-5-7-14/h3-10H,11-12H2,1-2H3,(H,24,31)(H,25,26)(H,28,32,33)
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n/an/a 4.11E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357758
PNG
(KM-05-100/(I-11) | US10214530, Example 11)
Show SMILES Cn1c2nc(Cc3nc4ccc(Br)cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H17BrN6O2/c1-27-19-18(20(29)26-21(27)30)28(11-12-5-3-2-4-6-12)17(25-19)10-16-23-14-8-7-13(22)9-15(14)24-16/h2-9H,10-11H2,1H3,(H,23,24)(H,26,29,30)
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n/an/a 4.14E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357759
PNG
(KM-05-127/(I-16) | US10214530, Example 16)
Show SMILES O=c1[nH]c(=O)c2n(Cc3ccccc3)c(Cc3nc4ccc(cc4[nH]3)C#N)nc2n1C1CC1
Show InChI InChI=1S/C24H19N7O2/c25-12-15-6-9-17-18(10-15)27-19(26-17)11-20-28-22-21(30(20)13-14-4-2-1-3-5-14)23(32)29-24(33)31(22)16-7-8-16/h1-6,9-10,16H,7-8,11,13H2,(H,26,27)(H,29,32,33)
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n/an/a 4.20E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357760
PNG
(KM-05-50/(I-4) | US10214530, Example 4)
Show SMILES Cn1c2nc(Cc3nc4cc(ccc4[nH]3)N3CCOCC3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H25N7O3/c1-30-23-22(24(33)29-25(30)34)32(15-16-5-3-2-4-6-16)21(28-23)14-20-26-18-8-7-17(13-19(18)27-20)31-9-11-35-12-10-31/h2-8,13H,9-12,14-15H2,1H3,(H,26,27)(H,29,33,34)
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n/an/a 5.83E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357761
PNG
(KM-05-55 Fr10-12/(l-6) | US10214530, Example 6)
Show SMILES Cn1c2nc(Cc3nc4ccc(N)cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H19N7O2/c1-27-19-18(20(29)26-21(27)30)28(11-12-5-3-2-4-6-12)17(25-19)10-16-23-14-8-7-13(22)9-15(14)24-16/h2-9H,10-11,22H2,1H3,(H,23,24)(H,26,29,30)
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n/an/a 6.19E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357762
PNG
(KM430/(I-31) | US10214530, Example 37)
Show SMILES Cn1c2nc(Sc3nc4cc(N)ccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H17N7O2S/c1-26-16-15(17(28)25-19(26)29)27(10-11-5-3-2-4-6-11)20(24-16)30-18-22-13-8-7-12(21)9-14(13)23-18/h2-9H,10,21H2,1H3,(H,22,23)(H,25,28,29)
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n/an/a 7.40E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357763
PNG
(KM-05-16/(I-3) | US10214530, Example 3)
Show SMILES Cn1c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H18N6O2/c1-26-19-18(20(28)25-21(26)29)27(12-13-7-3-2-4-8-13)17(24-19)11-16-22-14-9-5-6-10-15(14)23-16/h2-10H,11-12H2,1H3,(H,22,23)(H,25,28,29)
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n/an/a 8.28E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357764
PNG
(KM406/(I-24) | US10214530, Example 30)
Show SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H16N6O2S/c1-25-16-15(17(27)24-19(25)28)26(11-12-7-3-2-4-8-12)20(23-16)29-18-21-13-9-5-6-10-14(13)22-18/h2-10H,11H2,1H3,(H,21,22)(H,24,27,28)
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n/an/a 9.05E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357765
PNG
(KM422/(I-25) | US10214530, Example 31)
Show SMILES COc1ccc2[nH]c(Sc3nc4n(C)c(=O)[nH]c(=O)c4n3Cc3ccccc3)nc2c1
Show InChI InChI=1S/C21H18N6O3S/c1-26-17-16(18(28)25-20(26)29)27(11-12-6-4-3-5-7-12)21(24-17)31-19-22-14-9-8-13(30-2)10-15(14)23-19/h3-10H,11H2,1-2H3,(H,22,23)(H,25,28,29)
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n/an/a 9.48E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357766
PNG
(KM477/(I-40) | US10214530, Example 46)
Show SMILES Cn1c2nc(Sc3nc4cc(NC(=O)C[C@H](N)C(O)=O)ccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H22N8O5S/c1-31-19-18(20(34)30-23(31)37)32(11-12-5-3-2-4-6-12)24(29-19)38-22-27-15-8-7-13(9-16(15)28-22)26-17(33)10-14(25)21(35)36/h2-9,14H,10-11,25H2,1H3,(H,26,33)(H,27,28)(H,35,36)(H,30,34,37)/t14-/m0/s1
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n/an/a 9.72E+3n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357767
PNG
(KM-05-68/(I-8) | US10214530, Example 8)
Show SMILES Cn1c2nc(Cc3nc4ccc(cc4[nH]3)N3CCC(CC3)C(O)=O)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C27H27N7O4/c1-32-24-23(25(35)31-27(32)38)34(15-16-5-3-2-4-6-16)22(30-24)14-21-28-19-8-7-18(13-20(19)29-21)33-11-9-17(10-12-33)26(36)37/h2-8,13,17H,9-12,14-15H2,1H3,(H,28,29)(H,36,37)(H,31,35,38)
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n/an/a 1.07E+4n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357768
PNG
(KM501/(I-45) | US10214530, Example 51)
Show SMILES Cn1c2nc(Sc3nc4cc(NCC(O)=O)ccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H19N7O4S/c1-28-18-17(19(32)27-21(28)33)29(11-12-5-3-2-4-6-12)22(26-18)34-20-24-14-8-7-13(9-15(14)25-20)23-10-16(30)31/h2-9,23H,10-11H2,1H3,(H,24,25)(H,30,31)(H,27,32,33)
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n/an/a 1.45E+4n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357769
PNG
(KM446/(I-35) | US10214530, Example 41)
Show SMILES Cc1ccc2[nH]c(Sc3nc4n(C)c(=O)[nH]c(=O)c4n3Cc3cncs3)nc2c1
Show InChI InChI=1S/C18H15N7O2S2/c1-9-3-4-11-12(5-9)21-16(20-11)29-18-22-14-13(15(26)23-17(27)24(14)2)25(18)7-10-6-19-8-28-10/h3-6,8H,7H2,1-2H3,(H,20,21)(H,23,26,27)
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n/an/a 1.50E+4n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357779
PNG
(KM425/(I-28) | US10214530, Example 34)
Show SMILES Cn1c2nc(Sc3nc4cc(Cl)c(Cl)cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H14Cl2N6O2S/c1-27-16-15(17(29)26-19(27)30)28(9-10-5-3-2-4-6-10)20(25-16)31-18-23-13-7-11(21)12(22)8-14(13)24-18/h2-8H,9H2,1H3,(H,23,24)(H,26,29,30)
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n/an/a 1.57E+4n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357770
PNG
(KM424/(I-27) | US10214530, Example 33)
Show SMILES Cc1ccc2[nH]c(Sc3nc4n(C)c(=O)[nH]c(=O)c4n3Cc3ccccc3)nc2c1
Show InChI InChI=1S/C21H18N6O2S/c1-12-8-9-14-15(10-12)23-19(22-14)30-21-24-17-16(18(28)25-20(29)26(17)2)27(21)11-13-6-4-3-5-7-13/h3-10H,11H2,1-2H3,(H,22,23)(H,25,28,29)
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n/an/a 2.00E+4n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357771
PNG
(KM-05-180/(I-208) | US10214530, Example 26)
Show SMILES CCn1c2nc(Cc3nc4ncccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H19N7O2/c1-2-27-19-17(20(29)26-21(27)30)28(12-13-7-4-3-5-8-13)16(25-19)11-15-23-14-9-6-10-22-18(14)24-15/h3-10H,2,11-12H2,1H3,(H,22,23,24)(H,26,29,30)
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n/an/a 2.08E+4n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357772
PNG
(KM447/(I-36) | US10214530, Example 42)
Show SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3nccs3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C17H13N7O2S2/c1-23-13-12(14(25)22-16(23)26)24(8-11-18-6-7-27-11)17(21-13)28-15-19-9-4-2-3-5-10(9)20-15/h2-7H,8H2,1H3,(H,19,20)(H,22,25,26)
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n/an/a 2.52E+4n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357788
PNG
(MW-01-148/(I-302) | US10214530, Example 55)
Show SMILES CCn1c2nc(Nc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H19N7O2/c1-2-27-17-16(18(29)25-21(27)30)28(12-13-8-4-3-5-9-13)20(24-17)26-19-22-14-10-6-7-11-15(14)23-19/h3-11H,2,12H2,1H3,(H,25,29,30)(H2,22,23,24,26)
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n/an/a 2.93E+4n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357773
PNG
(KM489/(I-43) | US10214530, Example 49)
Show SMILES CC(=O)Nc1ccc(Cn2c(Sc3nc4ccccc4[nH]3)nc3n(C)c(=O)[nH]c(=O)c23)cc1
Show InChI InChI=1S/C22H19N7O3S/c1-12(30)23-14-9-7-13(8-10-14)11-29-17-18(28(2)21(32)27-19(17)31)26-22(29)33-20-24-15-5-3-4-6-16(15)25-20/h3-10H,11H2,1-2H3,(H,23,30)(H,24,25)(H,27,31,32)
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n/an/a 3.30E+4n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357774
PNG
(KM448/(I-37) | US10214530, Example 43)
Show SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3cnco3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C17H13N7O3S/c1-23-13-12(14(25)22-16(23)26)24(7-9-6-18-8-27-9)17(21-13)28-15-19-10-4-2-3-5-11(10)20-15/h2-6,8H,7H2,1H3,(H,19,20)(H,22,25,26)
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n/an/a 4.22E+4n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357775
PNG
(KM495/(I-44) | US10214530, Example 50)
Show SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccc(N)cc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H17N7O2S/c1-26-16-15(17(28)25-19(26)29)27(10-11-6-8-12(21)9-7-11)20(24-16)30-18-22-13-4-2-3-5-14(13)23-18/h2-9H,10,21H2,1H3,(H,22,23)(H,25,28,29)
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n/an/a 6.36E+4n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357776
PNG
(KM483/(I-42) | US10214530, Example 48)
Show SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccc(cc3)N3CCOCC3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H23N7O3S/c1-29-20-19(21(32)28-23(29)33)31(14-15-6-8-16(9-7-15)30-10-12-34-13-11-30)24(27-20)35-22-25-17-4-2-3-5-18(17)26-22/h2-9H,10-14H2,1H3,(H,25,26)(H,28,32,33)
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n/an/a 7.60E+4n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357789
PNG
(MW-01-162/(I-303) | US10214530, Example 56)
Show SMILES CCCn1c2nc(Nc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H21N7O2/c1-2-12-28-18-17(19(30)26-22(28)31)29(13-14-8-4-3-5-9-14)21(25-18)27-20-23-15-10-6-7-11-16(15)24-20/h3-11H,2,12-13H2,1H3,(H,26,30,31)(H2,23,24,25,27)
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n/an/a>2.00E+5n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357779
PNG
(KM425/(I-28) | US10214530, Example 34)
Show SMILES Cn1c2nc(Sc3nc4cc(Cl)c(Cl)cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H14Cl2N6O2S/c1-27-16-15(17(29)26-19(27)30)28(9-10-5-3-2-4-6-10)20(25-16)31-18-23-13-7-11(21)12(22)8-14(13)24-18/h2-8H,9H2,1H3,(H,23,24)(H,26,29,30)
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n/an/a>2.00E+5n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357783
PNG
(KM432/(I-33) | US10214530, Example 39)
Show SMILES Cn1c2nc(Sc3nc4cccnc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C19H15N7O2S/c1-25-15-13(16(27)24-18(25)28)26(10-11-6-3-2-4-7-11)19(23-15)29-17-21-12-8-5-9-20-14(12)22-17/h2-9H,10H2,1H3,(H,20,21,22)(H,24,27,28)
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n/an/a>2.00E+5n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357787
PNG
(KM-05-145/(I-301) | US10214530, Example 54)
Show SMILES Cn1c2nc(Nc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H17N7O2/c1-26-16-15(17(28)24-20(26)29)27(11-12-7-3-2-4-8-12)19(23-16)25-18-21-13-9-5-6-10-14(13)22-18/h2-10H,11H2,1H3,(H,24,28,29)(H2,21,22,23,25)
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n/an/a>2.00E+5n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357782
PNG
(KM431/(I-32) | US10214530, Example 38)
Show SMILES Cn1c2nc(Sc3nc4ccccc4s3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H15N5O2S2/c1-24-16-15(17(26)23-18(24)27)25(11-12-7-3-2-4-8-12)19(22-16)29-20-21-13-9-5-6-10-14(13)28-20/h2-10H,11H2,1H3,(H,23,26,27)
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n/an/a>2.00E+5n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357787
PNG
(KM-05-145/(I-301) | US10214530, Example 54)
Show SMILES Cn1c2nc(Nc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H17N7O2/c1-26-16-15(17(28)24-20(26)29)27(11-12-7-3-2-4-8-12)19(23-16)25-18-21-13-9-5-6-10-14(13)22-18/h2-10H,11H2,1H3,(H,24,28,29)(H2,21,22,23,25)
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n/an/a>2.00E+5n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357778
PNG
(KM423/(I-26) | US10214530, Example 32)
Show SMILES CCn1c(Sc2nc3n(C)c(=O)[nH]c(=O)c3n2Cc2ccccc2)nc2ccccc12
Show InChI InChI=1S/C22H20N6O2S/c1-3-27-16-12-8-7-11-15(16)23-21(27)31-22-24-18-17(19(29)25-20(30)26(18)2)28(22)13-14-9-5-4-6-10-14/h4-12H,3,13H2,1-2H3,(H,25,29,30)
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n/an/a>2.00E+5n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357785
PNG
(KM449/(I-38) | US10214530, Example 44)
Show SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccco3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C18H14N6O3S/c1-23-14-13(15(25)22-17(23)26)24(9-10-5-4-8-27-10)18(21-14)28-16-19-11-6-2-3-7-12(11)20-16/h2-8H,9H2,1H3,(H,19,20)(H,22,25,26)
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n/an/a>2.00E+5n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357777
PNG
(KM-05-52/(I-5) | US10214530, Example 5)
Show SMILES CN1CCN(CC1)c1ccc2nc(Cc3nc4n(C)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
Show InChI InChI=1S/C26H28N8O2/c1-31-10-12-33(13-11-31)18-8-9-19-20(14-18)28-21(27-19)15-22-29-24-23(25(35)30-26(36)32(24)2)34(22)16-17-6-4-3-5-7-17/h3-9,14H,10-13,15-16H2,1-2H3,(H,27,28)(H,30,35,36)
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n/an/a>2.00E+5n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357784
PNG
(KM435/(I-34) | US10214530, Example 40)
Show SMILES Cc1nnc(Cn2c(Sc3nc4ccccc4[nH]3)nc3n(C)c(=O)[nH]c(=O)c23)o1
Show InChI InChI=1S/C17H14N8O3S/c1-8-22-23-11(28-8)7-25-12-13(24(2)16(27)21-14(12)26)20-17(25)29-15-18-9-5-3-4-6-10(9)19-15/h3-6H,7H2,1-2H3,(H,18,19)(H,21,26,27)
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n/an/a>2.00E+5n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357781
PNG
(KM429/(I-30) | US10214530, Example 36)
Show SMILES Cn1c2nc(Sc3nc4ccc(cc4[nH]3)C(O)=O)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H16N6O4S/c1-26-16-15(17(28)25-20(26)31)27(10-11-5-3-2-4-6-11)21(24-16)32-19-22-13-8-7-12(18(29)30)9-14(13)23-19/h2-9H,10H2,1H3,(H,22,23)(H,29,30)(H,25,28,31)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357778
PNG
(KM423/(I-26) | US10214530, Example 32)
Show SMILES CCn1c(Sc2nc3n(C)c(=O)[nH]c(=O)c3n2Cc2ccccc2)nc2ccccc12
Show InChI InChI=1S/C22H20N6O2S/c1-3-27-16-12-8-7-11-15(16)23-21(27)31-22-24-18-17(19(29)25-20(30)26(18)2)28(22)13-14-9-5-4-6-10-14/h4-12H,3,13H2,1-2H3,(H,25,29,30)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357788
PNG
(MW-01-148/(I-302) | US10214530, Example 55)
Show SMILES CCn1c2nc(Nc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H19N7O2/c1-2-27-17-16(18(29)25-21(27)30)28(12-13-8-4-3-5-9-13)20(24-17)26-19-22-14-10-6-7-11-15(14)23-19/h3-11H,2,12H2,1H3,(H,25,29,30)(H2,22,23,24,26)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357782
PNG
(KM431/(I-32) | US10214530, Example 38)
Show SMILES Cn1c2nc(Sc3nc4ccccc4s3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H15N5O2S2/c1-24-16-15(17(26)23-18(24)27)25(11-12-7-3-2-4-8-12)19(22-16)29-20-21-13-9-5-6-10-14(13)28-20/h2-10H,11H2,1H3,(H,23,26,27)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357786
PNG
(KM450/(I-39) | US10214530, Example 45)
Show SMILES Cc1ccc2[nH]c(Sc3nc4n(C)c(=O)[nH]c(=O)c4n3Cc3ccco3)nc2c1
Show InChI InChI=1S/C19H16N6O3S/c1-10-5-6-12-13(8-10)21-17(20-12)29-19-22-15-14(16(26)23-18(27)24(15)2)25(19)9-11-4-3-7-28-11/h3-8H,9H2,1-2H3,(H,20,21)(H,23,26,27)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357781
PNG
(KM429/(I-30) | US10214530, Example 36)
Show SMILES Cn1c2nc(Sc3nc4ccc(cc4[nH]3)C(O)=O)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H16N6O4S/c1-26-16-15(17(28)25-20(26)31)27(10-11-5-3-2-4-6-11)21(24-16)32-19-22-13-8-7-12(18(29)30)9-14(13)23-19/h2-9H,10H2,1H3,(H,22,23)(H,29,30)(H,25,28,31)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357789
PNG
(MW-01-162/(I-303) | US10214530, Example 56)
Show SMILES CCCn1c2nc(Nc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H21N7O2/c1-2-12-28-18-17(19(30)26-22(28)31)29(13-14-8-4-3-5-9-14)21(25-18)27-20-23-15-10-6-7-11-16(15)24-20/h3-11H,2,12-13H2,1H3,(H,26,30,31)(H2,23,24,25,27)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357780
PNG
(KM427/(I-29) | US10214530, Example 35)
Show SMILES Cn1c2nc(Sc3nc4cc(ccc4[nH]3)S(O)(=O)=O)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H16N6O5S2/c1-25-16-15(17(27)24-19(25)28)26(10-11-5-3-2-4-6-11)20(23-16)32-18-21-13-8-7-12(33(29,30)31)9-14(13)22-18/h2-9H,10H2,1H3,(H,21,22)(H,24,27,28)(H,29,30,31)
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US Patent
n/an/a>2.00E+5n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357780
PNG
(KM427/(I-29) | US10214530, Example 35)
Show SMILES Cn1c2nc(Sc3nc4cc(ccc4[nH]3)S(O)(=O)=O)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H16N6O5S2/c1-25-16-15(17(27)24-19(25)28)26(10-11-5-3-2-4-6-11)20(23-16)32-18-21-13-8-7-12(33(29,30)31)9-14(13)22-18/h2-9H,10H2,1H3,(H,21,22)(H,24,27,28)(H,29,30,31)
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US Patent
n/an/a>2.00E+5n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase_UNCURATED


(Homo sapiens (Human))
BDBM357784
PNG
(KM435/(I-34) | US10214530, Example 40)
Show SMILES Cc1nnc(Cn2c(Sc3nc4ccccc4[nH]3)nc3n(C)c(=O)[nH]c(=O)c23)o1
Show InChI InChI=1S/C17H14N8O3S/c1-8-22-23-11(28-8)7-25-12-13(24(2)16(27)21-14(12)26)20-17(25)29-15-18-9-5-3-4-6-10(9)19-15/h3-6H,7H2,1-2H3,(H,18,19)(H,21,26,27)
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n/an/a>2.00E+5n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%