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Patent code US10214544

Compile Data Set for Download or QSAR
Found 155 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358197
PNG
(US10214544, Example 10)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(Br)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21BrN4O5S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-5-3-8-19(9-16)30-26(34)17-6-4-7-18(29)10-17/h3-14H,15H2,1-2H3,(H,30,34)
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n/an/an/an/a 1.90n/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358260
PNG
(US10214544, Example 21)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4c(F)cc(F)cc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H19F3N4O5S/c1-37-17-9-22(18-11-24(40-23(18)10-17)21-12-35-27(33-21)41-28(34-35)38-2)39-13-14-4-3-5-16(6-14)32-26(36)25-19(30)7-15(29)8-20(25)31/h3-12H,13H2,1-2H3,(H,32,36)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358266
PNG
(US10214544, Example 23)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc5ccccc5c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C32H24N4O5S/c1-38-24-14-27(25-16-29(41-28(25)15-24)26-17-36-31(34-26)42-32(35-36)39-2)40-18-19-6-5-9-23(12-19)33-30(37)22-11-10-20-7-3-4-8-21(20)13-22/h3-17H,18H2,1-2H3,(H,33,37)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358343
PNG
(US10214544, Example 25)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4Cl)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21ClN4O5S/c1-35-18-11-23(20-13-25(38-24(20)12-18)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-6-5-7-17(10-16)30-26(34)19-8-3-4-9-21(19)29/h3-14H,15H2,1-2H3,(H,30,34)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358474
PNG
(US10214544, Example 32)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(C)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O5S/c1-17-7-9-19(10-8-17)27(34)30-20-6-4-5-18(11-20)16-37-24-12-21(35-2)13-25-22(24)14-26(38-25)23-15-33-28(31-23)39-29(32-33)36-3/h4-15H,16H2,1-3H3,(H,30,34)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358481
PNG
(US10214544, Example 33)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(cc4)[N+]([O-])=O)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21N5O7S/c1-37-20-11-23(21-13-25(40-24(21)12-20)22-14-32-27(30-22)41-28(31-32)38-2)39-15-16-4-3-5-18(10-16)29-26(34)17-6-8-19(9-7-17)33(35)36/h3-14H,15H2,1-2H3,(H,29,34)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358487
PNG
(US10214544, Example 34)
Show SMILES COC(=O)c1ccc(cc1)C(=O)Nc1cccc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)c1
Show InChI InChI=1S/C30H24N4O7S/c1-37-21-12-24(22-14-26(41-25(22)13-21)23-15-34-29(32-23)42-30(33-34)39-3)40-16-17-5-4-6-20(11-17)31-27(35)18-7-9-19(10-8-18)28(36)38-2/h4-15H,16H2,1-3H3,(H,31,35)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358496
PNG
(US10214544, Example 37)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(cc4)C(C)(C)C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C32H30N4O5S/c1-32(2,3)21-11-9-20(10-12-21)29(37)33-22-8-6-7-19(13-22)18-40-26-14-23(38-4)15-27-24(26)16-28(41-27)25-17-36-30(34-25)42-31(35-36)39-5/h6-17H,18H2,1-5H3,(H,33,37)
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358763
PNG
(US10214544, Example 68)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cn5nc(sc5n4)C(C)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21F2N7O5S2/c1-28(29,30)24-34-36-12-19(33-25(36)43-24)23(38)31-15-6-4-5-14(7-15)13-41-20-8-16(39-2)9-21-17(20)10-22(42-21)18-11-37-26(32-18)44-27(35-37)40-3/h4-12H,13H2,1-3H3,(H,31,38)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358765
PNG
(US10214544, Example 70)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4csc(n4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H18F3N5O5S2/c1-36-15-7-19(16-9-21(39-20(16)8-15)17-10-34-24(32-17)41-25(33-34)37-2)38-11-13-4-3-5-14(6-13)30-22(35)18-12-40-23(31-18)26(27,28)29/h3-10,12H,11H2,1-2H3,(H,30,35)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358769
PNG
(US10214544, Example 74)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(OC(F)F)cc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H21F5N4O6S/c1-41-19-10-23(21-12-25(45-24(21)11-19)22-13-39-28(37-22)46-29(38-39)42-2)43-14-15-4-3-5-18(6-15)36-26(40)16-7-17(30(33,34)35)9-20(8-16)44-27(31)32/h3-13,27H,14H2,1-2H3,(H,36,40)
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358780
PNG
(US10214544, Example 86)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3ccccc3OC)cc(OC)cc2o1
Show InChI InChI=1S/C30H26N4O6S/c1-33(28(35)21-10-5-6-11-24(21)37-3)19-9-7-8-18(12-19)17-39-25-13-20(36-2)14-26-22(25)15-27(40-26)23-16-34-29(31-23)41-30(32-34)38-4/h5-16H,17H2,1-4H3
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358784
PNG
(US10214544, Example 90)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3ccc(OC)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N5O6S/c1-33(27(35)18-8-9-26(37-3)30-14-18)19-7-5-6-17(10-19)16-39-23-11-20(36-2)12-24-21(23)13-25(40-24)22-15-34-28(31-22)41-29(32-34)38-4/h5-15H,16H2,1-4H3
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358788
PNG
(US10214544, Example 94)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(C)=O)cc(OC)cc2o1
Show InChI InChI=1S/C24H22N4O5S/c1-14(29)27(2)16-7-5-6-15(8-16)13-32-20-9-17(30-3)10-21-18(20)11-22(33-21)19-12-28-23(25-19)34-24(26-28)31-4/h5-12H,13H2,1-4H3
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358789
PNG
(US10214544, Example 97)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C=O)cc(OC)cc2o1
Show InChI InChI=1S/C23H20N4O5S/c1-26(13-28)15-6-4-5-14(7-15)12-31-19-8-16(29-2)9-20-17(19)10-21(32-20)18-11-27-22(24-18)33-23(25-27)30-3/h4-11,13H,12H2,1-3H3
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358796
PNG
(US10214544, Example 107)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(C)=O)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C25H22N4O5S/c1-14(30)28-7-6-16-5-4-15(8-20(16)28)13-33-21-9-17(31-2)10-22-18(21)11-23(34-22)19-12-29-24(26-19)35-25(27-29)32-3/h4-5,8-12H,6-7,13H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358813
PNG
(US10214544, Example 127)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccc(OC)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C30H25N5O6S/c1-37-19-11-24(21-13-26(41-25(21)12-19)22-15-35-29(32-22)42-30(33-35)39-3)40-16-18-5-4-6-23-20(18)9-10-34(23)28(36)17-7-8-27(38-2)31-14-17/h4-8,11-15H,9-10,16H2,1-3H3
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358823
PNG
(US10214544, Example 138)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)CC4CCCC4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H28N4O5S/c1-34-20-12-23(36-16-18-8-5-9-19(10-18)29-26(33)11-17-6-3-4-7-17)21-14-25(37-24(21)13-20)22-15-32-27(30-22)38-28(31-32)35-2/h5,8-10,12-15,17H,3-4,6-7,11,16H2,1-2H3,(H,29,33)
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358835
PNG
(US10214544, Example 150)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)C4CCCCC4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H28N4O5S/c1-34-20-12-23(36-16-17-7-6-10-19(11-17)29-26(33)18-8-4-3-5-9-18)21-14-25(37-24(21)13-20)22-15-32-27(30-22)38-28(31-32)35-2/h6-7,10-15,18H,3-5,8-9,16H2,1-2H3,(H,29,33)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358838
PNG
(US10214544, Example 153)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(cc4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21F3N4O5S/c1-38-20-11-23(21-13-25(41-24(21)12-20)22-14-36-27(34-22)42-28(35-36)39-2)40-15-16-4-3-5-19(10-16)33-26(37)17-6-8-18(9-7-17)29(30,31)32/h3-14H,15H2,1-2H3,(H,33,37)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358839
PNG
(US10214544, Example 154)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(F)ccc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F2N4O5S/c1-36-18-10-23(20-12-25(39-24(20)11-18)22-13-34-27(32-22)40-28(33-34)37-2)38-14-15-4-3-5-17(8-15)31-26(35)19-9-16(29)6-7-21(19)30/h3-13H,14H2,1-2H3,(H,31,35)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358521
PNG
(US10214544, Example 155 | US10214544, Example 44)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccno4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C25H19N5O6S/c1-32-16-9-20(34-13-14-4-3-5-15(8-14)27-23(31)19-6-7-26-36-19)17-11-22(35-21(17)10-16)18-12-30-24(28-18)37-25(29-30)33-2/h3-12H,13H2,1-2H3,(H,27,31)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358845
PNG
(US10214544, Example 160)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(OC)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O6S/c1-35-20-9-5-7-18(11-20)27(34)30-19-8-4-6-17(10-19)16-38-24-12-21(36-2)13-25-22(24)14-26(39-25)23-15-33-28(31-23)40-29(32-33)37-3/h4-15H,16H2,1-3H3,(H,30,34)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358847
PNG
(US10214544, Example 162)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4c(OC)cccc4OC)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H26N4O7S/c1-36-19-12-24(20-14-26(41-25(20)13-19)21-15-34-29(32-21)42-30(33-34)39-4)40-16-17-7-5-8-18(11-17)31-28(35)27-22(37-2)9-6-10-23(27)38-3/h5-15H,16H2,1-4H3,(H,31,35)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358156
PNG
(N-(3-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H22N4O5S/c1-34-20-12-23(36-16-17-7-6-10-19(11-17)29-26(33)18-8-4-3-5-9-18)21-14-25(37-24(21)13-20)22-15-32-27(30-22)38-28(31-32)35-2/h3-15H,16H2,1-2H3,(H,29,33)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358202
PNG
(US10214544, Example 12)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4c(Cl)cccc4Cl)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20Cl2N4O5S/c1-36-17-10-22(18-12-24(39-23(18)11-17)21-13-34-27(32-21)40-28(33-34)37-2)38-14-15-5-3-6-16(9-15)31-26(35)25-19(29)7-4-8-20(25)30/h3-13H,14H2,1-2H3,(H,31,35)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358523
PNG
(US10214544, Example 46)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(OC)nc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N5O6S/c1-35-19-10-22(20-12-24(39-23(20)11-19)21-14-33-27(31-21)40-28(32-33)37-3)38-15-16-5-4-6-18(9-16)30-26(34)17-7-8-25(36-2)29-13-17/h4-14H,15H2,1-3H3,(H,30,34)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358548
PNG
(US10214544, Example 49)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)Cc4nc(C)sc4C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H25N5O5S2/c1-15-21(29-16(2)39-15)12-26(34)30-18-7-5-6-17(8-18)14-37-23-9-19(35-3)10-24-20(23)11-25(38-24)22-13-33-27(31-22)40-28(32-33)36-4/h5-11,13H,12,14H2,1-4H3,(H,30,34)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358560
PNG
(US10214544, Example 53)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(Cl)nc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H20ClN5O5S/c1-35-18-9-21(19-11-23(38-22(19)10-18)20-13-33-26(31-20)39-27(32-33)36-2)37-14-15-4-3-5-17(8-15)30-25(34)16-6-7-24(28)29-12-16/h3-13H,14H2,1-2H3,(H,30,34)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358580
PNG
(US10214544, Example 60)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cnoc4-c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H23N5O6S/c1-38-21-12-25(22-14-27(41-26(22)13-21)24-16-36-30(34-24)43-31(35-36)39-2)40-17-18-7-6-10-20(11-18)33-29(37)23-15-32-42-28(23)19-8-4-3-5-9-19/h3-16H,17H2,1-2H3,(H,33,37)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358759
PNG
(US10214544, Example 64)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(C)nc4Cl)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H22ClN5O5S/c1-15-7-8-19(25(29)30-15)26(35)31-17-6-4-5-16(9-17)14-38-22-10-18(36-2)11-23-20(22)12-24(39-23)21-13-34-27(32-21)40-28(33-34)37-3/h4-13H,14H2,1-3H3,(H,31,35)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358760
PNG
(US10214544, Example 65)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(Br)cn4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H20BrN5O5S/c1-35-18-9-22(19-11-24(38-23(19)10-18)21-13-33-26(31-21)39-27(32-33)36-2)37-14-15-4-3-5-17(8-15)30-25(34)20-7-6-16(28)12-29-20/h3-13H,14H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358764
PNG
(US10214544, Example 69)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccnnc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H20N6O5S/c1-34-18-9-21(36-14-15-4-3-5-17(8-15)29-24(33)16-6-7-27-28-12-16)19-11-23(37-22(19)10-18)20-13-32-25(30-20)38-26(31-32)35-2/h3-13H,14H2,1-2H3,(H,29,33)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358783
PNG
(US10214544, Example 89)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3ccc(C)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C30H26N4O5S/c1-18-8-10-20(11-9-18)28(35)33(2)21-7-5-6-19(12-21)17-38-25-13-22(36-3)14-26-23(25)15-27(39-26)24-16-34-29(31-24)40-30(32-34)37-4/h5-16H,17H2,1-4H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358797
PNG
(US10214544, Example 110)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5csc(n5)C(F)(F)F)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F3N5O5S2/c1-38-16-8-21(17-10-23(41-22(17)9-16)18-11-36-26(33-18)43-27(34-36)39-2)40-12-14-3-4-15-5-6-35(20(15)7-14)24(37)19-13-42-25(32-19)28(29,30)31/h3-4,7-11,13H,5-6,12H2,1-2H3
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358803
PNG
(US10214544, Example 117)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(C)=O)cc(OC)cc2o1
Show InChI InChI=1S/C25H22N4O5S/c1-14(30)28-8-7-17-15(5-4-6-20(17)28)13-33-21-9-16(31-2)10-22-18(21)11-23(34-22)19-12-29-24(26-19)35-25(27-29)32-3/h4-6,9-12H,7-8,13H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358807
PNG
(US10214544, Example 121)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3cccc(F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H23FN4O5S/c1-37-20-12-25(22-14-27(40-26(22)13-20)23-15-35-29(32-23)41-30(33-35)38-2)39-16-18-6-4-8-24-21(18)9-10-34(24)28(36)17-5-3-7-19(31)11-17/h3-8,11-15H,9-10,16H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358825
PNG
(US10214544, Example 140)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(ccc4F)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H20F4N4O5S/c1-39-18-10-23(20-12-25(42-24(20)11-18)22-13-37-27(35-22)43-28(36-37)40-2)41-14-15-4-3-5-17(8-15)34-26(38)19-9-16(29(31,32)33)6-7-21(19)30/h3-13H,14H2,1-2H3,(H,34,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358828
PNG
(US10214544, Example 143)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4c(F)cccc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F2N4O5S/c1-36-17-10-22(18-12-24(39-23(18)11-17)21-13-34-27(32-21)40-28(33-34)37-2)38-14-15-5-3-6-16(9-15)31-26(35)25-19(29)7-4-8-20(25)30/h3-13H,14H2,1-2H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358841
PNG
(US10214544, Example 156)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(Cl)c4Cl)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20Cl2N4O5S/c1-36-17-10-22(19-12-24(39-23(19)11-17)21-13-34-27(32-21)40-28(33-34)37-2)38-14-15-5-3-6-16(9-15)31-26(35)18-7-4-8-20(29)25(18)30/h3-13H,14H2,1-2H3,(H,31,35)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358849
PNG
(US10214544, Example 164)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(OC(F)F)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H22F2N4O6S/c1-37-20-11-23(21-13-25(41-24(21)12-20)22-14-35-28(33-22)42-29(34-35)38-2)39-15-16-4-3-5-18(10-16)32-26(36)17-6-8-19(9-7-17)40-27(30)31/h3-14,27H,15H2,1-2H3,(H,32,36)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358220
PNG
(US10214544, Example 14)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(F)c(F)c4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H19F3N4O5S/c1-37-16-9-21(18-11-23(40-22(18)10-16)20-12-35-27(33-20)41-28(34-35)38-2)39-13-14-4-3-5-15(8-14)32-26(36)17-6-7-19(29)25(31)24(17)30/h3-12H,13H2,1-2H3,(H,32,36)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358234
PNG
(US10214544, Example 18)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(OC)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O6S/c1-35-20-9-7-18(8-10-20)27(34)30-19-6-4-5-17(11-19)16-38-24-12-21(36-2)13-25-22(24)14-26(39-25)23-15-33-28(31-23)40-29(32-33)37-3/h4-15H,16H2,1-3H3,(H,30,34)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358497
PNG
(US10214544, Example 38)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)NCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N5O5S/c1-36-21-12-24(22-14-26(39-25(22)13-21)23-16-34-28(32-23)40-29(33-34)37-2)38-17-19-9-6-10-20(11-19)31-27(35)30-15-18-7-4-3-5-8-18/h3-14,16H,15,17H2,1-2H3,(H2,30,31,35)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358508
PNG
(US10214544, Example 41)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(OC(F)(F)F)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21F3N4O6S/c1-38-20-11-23(21-13-25(41-24(21)12-20)22-14-36-27(34-22)43-28(35-36)39-2)40-15-16-4-3-5-18(10-16)33-26(37)17-6-8-19(9-7-17)42-29(30,31)32/h3-14H,15H2,1-2H3,(H,33,37)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358510
PNG
(US10214544, Example 42)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(OC)cc4OC)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H26N4O7S/c1-36-19-8-9-21(24(11-19)38-3)28(35)31-18-7-5-6-17(10-18)16-40-25-12-20(37-2)13-26-22(25)14-27(41-26)23-15-34-29(32-23)42-30(33-34)39-4/h5-15H,16H2,1-4H3,(H,31,35)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358517
PNG
(US10214544, Example 43)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(cc4)N(C)C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H27N5O5S/c1-34(2)21-10-8-19(9-11-21)28(36)31-20-7-5-6-18(12-20)17-39-25-13-22(37-3)14-26-23(25)15-27(40-26)24-16-35-29(32-24)41-30(33-35)38-4/h5-16H,17H2,1-4H3,(H,31,36)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358552
PNG
(US10214544, Example 52)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4)c3)cccc2o1
Show InChI InChI=1S/C27H20N4O4S/c1-33-27-30-31-15-21(29-26(31)36-27)24-14-20-22(11-6-12-23(20)35-24)34-16-17-7-5-10-19(13-17)28-25(32)18-8-3-2-4-9-18/h2-15H,16H2,1H3,(H,28,32)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358761
PNG
(US10214544, Example 66)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cnc(nc4C)-c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C33H26N6O5S/c1-19-25(16-34-30(35-19)21-9-5-4-6-10-21)31(40)36-22-11-7-8-20(12-22)18-43-27-13-23(41-2)14-28-24(27)15-29(44-28)26-17-39-32(37-26)45-33(38-39)42-3/h4-17H,18H2,1-3H3,(H,36,40)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358774
PNG
(US10214544, Example 80)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4csc(n4)-c4cccc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C32H22F3N5O5S2/c1-42-21-11-25(22-13-27(45-26(22)12-21)23-14-40-30(38-23)47-31(39-40)43-2)44-15-17-5-3-8-20(9-17)36-28(41)24-16-46-29(37-24)18-6-4-7-19(10-18)32(33,34)35/h3-14,16H,15H2,1-2H3,(H,36,41)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358775
PNG
(US10214544, Example 81 | tert-Butyl (3-(((6-methox...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)OC(C)(C)C)cc(OC)cc2o1
Show InChI InChI=1S/C27H28N4O6S/c1-27(2,3)37-26(32)30(4)17-9-7-8-16(10-17)15-35-21-11-18(33-5)12-22-19(21)13-23(36-22)20-14-31-24(28-20)38-25(29-31)34-6/h7-14H,15H2,1-6H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358787
PNG
(US10214544, Example 93)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3sc(C)nc3C)cc(OC)cc2o1
Show InChI InChI=1S/C28H25N5O5S2/c1-15-25(39-16(2)29-15)26(34)32(3)18-8-6-7-17(9-18)14-37-22-10-19(35-4)11-23-20(22)12-24(38-23)21-13-33-27(30-21)40-28(31-33)36-5/h6-13H,14H2,1-5H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358791
PNG
(US10214544, Example 102)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5cccc(F)c5)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H23FN4O5S/c1-37-21-12-25(22-14-27(40-26(22)13-21)23-15-35-29(32-23)41-30(33-35)38-2)39-16-17-6-7-18-8-9-34(24(18)10-17)28(36)19-4-3-5-20(31)11-19/h3-7,10-15H,8-9,16H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358800
PNG
(6-(4-(Indolin-4-ylmethoxy)-6-methoxybenzofuran-2-y...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4NCCc34)cc(OC)cc2o1
Show InChI InChI=1S/C23H20N4O4S/c1-28-14-8-19(30-12-13-4-3-5-17-15(13)6-7-24-17)16-10-21(31-20(16)9-14)18-11-27-22(25-18)32-23(26-27)29-2/h3-5,8-11,24H,6-7,12H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358805
PNG
(US10214544, Example 119)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3csc(n3)-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C33H25N5O5S2/c1-40-21-13-27(23-15-29(43-28(23)14-21)24-16-38-32(35-24)45-33(36-38)41-2)42-17-20-9-6-10-26-22(20)11-12-37(26)31(39)25-18-44-30(34-25)19-7-4-3-5-8-19/h3-10,13-16,18H,11-12,17H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358816
PNG
(US10214544, Example 130)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3cc(OC(F)F)cc(c3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C32H23F5N4O6S/c1-43-19-11-25(22-13-27(47-26(22)12-19)23-14-41-30(38-23)48-31(39-41)44-2)45-15-16-4-3-5-24-21(16)6-7-40(24)28(42)17-8-18(32(35,36)37)10-20(9-17)46-29(33)34/h3-5,8-14,29H,6-7,15H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358820
PNG
(US10214544, Example 135)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)Cc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O5S/c1-35-21-13-24(22-15-26(38-25(22)14-21)23-16-33-28(31-23)39-29(32-33)36-2)37-17-19-9-6-10-20(11-19)30-27(34)12-18-7-4-3-5-8-18/h3-11,13-16H,12,17H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358827
PNG
(US10214544, Example 142)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(F)cc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H20F4N4O5S/c1-39-20-10-23(21-12-25(42-24(21)11-20)22-13-37-27(35-22)43-28(36-37)40-2)41-14-15-4-3-5-19(6-15)34-26(38)16-7-17(29(31,32)33)9-18(30)8-16/h3-13H,14H2,1-2H3,(H,34,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358848
PNG
(US10214544, Example 163)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(C)c(F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H23FN4O5S/c1-16-7-8-18(10-22(16)30)27(35)31-19-6-4-5-17(9-19)15-38-24-11-20(36-2)12-25-21(24)13-26(39-25)23-14-34-28(32-23)40-29(33-34)37-3/h4-14H,15H2,1-3H3,(H,31,35)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358175
PNG
(US10214544, Example 3 | tert-Butyl (3-(((6-methoxy...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)OC(C)(C)C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O6S/c1-26(2,3)36-24(31)27-16-8-6-7-15(9-16)14-34-20-10-17(32-4)11-21-18(20)12-22(35-21)19-13-30-23(28-19)37-25(29-30)33-5/h6-13H,14H2,1-5H3,(H,27,31)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358191
PNG
(N-(3-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NS(=O)(=O)c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N4O6S2/c1-34-19-12-23(21-14-25(37-24(21)13-19)22-15-31-26(28-22)38-27(29-31)35-2)36-16-17-7-6-8-18(11-17)30-39(32,33)20-9-4-3-5-10-20/h3-15,30H,16H2,1-2H3
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358222
PNG
(US10214544, Example 16)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(c4)C#N)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21N5O5S/c1-36-21-11-24(22-13-26(39-25(22)12-21)23-15-34-28(32-23)40-29(33-34)37-2)38-16-18-6-4-8-20(10-18)31-27(35)19-7-3-5-17(9-19)14-30/h3-13,15H,16H2,1-2H3,(H,31,35)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358280
PNG
(US10214544, Example 24)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4I)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21IN4O5S/c1-35-18-11-23(20-13-25(38-24(20)12-18)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-6-5-7-17(10-16)30-26(34)19-8-3-4-9-21(19)29/h3-14H,15H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358409
PNG
(US10214544, Example 27)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O5S/c1-17-7-4-5-10-21(17)27(34)30-19-9-6-8-18(11-19)16-37-24-12-20(35-2)13-25-22(24)14-26(38-25)23-15-33-28(31-23)39-29(32-33)36-3/h4-15H,16H2,1-3H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358410
PNG
(US10214544, Example 28)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21FN4O5S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-5-3-8-19(9-16)30-26(34)17-6-4-7-18(29)10-17/h3-14H,15H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358411
PNG
(US10214544, Example 29)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4OC)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O6S/c1-35-19-12-24(21-14-26(39-25(21)13-19)22-15-33-28(31-22)40-29(32-33)37-3)38-16-17-7-6-8-18(11-17)30-27(34)20-9-4-5-10-23(20)36-2/h4-15H,16H2,1-3H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358473
PNG
(US10214544, Example 31)
Show SMILES CCCc1ccc(cc1)C(=O)Nc1cccc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)c1
Show InChI InChI=1S/C31H28N4O5S/c1-4-6-19-9-11-21(12-10-19)29(36)32-22-8-5-7-20(13-22)18-39-26-14-23(37-2)15-27-24(26)16-28(40-27)25-17-35-30(33-25)41-31(34-35)38-3/h5,7-17H,4,6,18H2,1-3H3,(H,32,36)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358488
PNG
(US10214544, Example 35)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)COc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O6S/c1-35-21-12-24(22-14-26(39-25(22)13-21)23-15-33-28(31-23)40-29(32-33)36-2)38-16-18-7-6-8-19(11-18)30-27(34)17-37-20-9-4-3-5-10-20/h3-15H,16-17H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358542
PNG
(US10214544, Example 48)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccnc(F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H20FN5O5S/c1-35-18-10-21(19-12-23(38-22(19)11-18)20-13-33-26(31-20)39-27(32-33)36-2)37-14-15-4-3-5-17(8-15)30-25(34)16-6-7-29-24(28)9-16/h3-13H,14H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358549
PNG
(US10214544, Example 50)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4sc(C)nc4C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H23N5O5S2/c1-14-24(38-15(2)28-14)25(33)29-17-7-5-6-16(8-17)13-36-21-9-18(34-3)10-22-19(21)11-23(37-22)20-12-32-26(30-20)39-27(31-32)35-4/h5-12H,13H2,1-4H3,(H,29,33)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358758
PNG
(US10214544, Example 63)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(Cl)cc(OC)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H23ClN4O6S/c1-36-20-9-17(8-18(30)10-20)27(35)31-19-6-4-5-16(7-19)15-39-24-11-21(37-2)12-25-22(24)13-26(40-25)23-14-34-28(32-23)41-29(33-34)38-3/h4-14H,15H2,1-3H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358772
PNG
(US10214544, Example 77)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4csc(n4)-c4ccc(F)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H22FN5O5S2/c1-39-21-11-25(22-13-27(42-26(22)12-21)23-14-37-30(35-23)44-31(36-37)40-2)41-15-17-4-3-5-20(10-17)33-28(38)24-16-43-29(34-24)18-6-8-19(32)9-7-18/h3-14,16H,15H2,1-2H3,(H,33,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358776
PNG
(3-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]th...)
Show SMILES CNc1cccc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)c1
Show InChI InChI=1S/C22H20N4O4S/c1-23-14-6-4-5-13(7-14)12-29-18-8-15(27-2)9-19-16(18)10-20(30-19)17-11-26-21(24-17)31-22(25-26)28-3/h4-11,23H,12H2,1-3H3
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358777
PNG
(N-(3-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O5S/c1-32(27(34)19-9-5-4-6-10-19)20-11-7-8-18(12-20)17-37-24-13-21(35-2)14-25-22(24)15-26(38-25)23-16-33-28(30-23)39-29(31-33)36-3/h4-16H,17H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358781
PNG
(US10214544, Example 87)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C29H23FN4O5S/c1-33(27(35)18-7-9-19(30)10-8-18)20-6-4-5-17(11-20)16-38-24-12-21(36-2)13-25-22(24)14-26(39-25)23-15-34-28(31-23)40-29(32-34)37-3/h4-15H,16H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358785
PNG
(US10214544, Example 91)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)S(=O)(=O)c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C28H24N4O6S2/c1-31(40(33,34)21-10-5-4-6-11-21)19-9-7-8-18(12-19)17-37-24-13-20(35-2)14-25-22(24)15-26(38-25)23-16-32-27(29-23)39-28(30-32)36-3/h4-16H,17H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358801
PNG
((4-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]t...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C30H24N4O5S/c1-36-20-13-25(22-15-27(39-26(22)14-20)23-16-34-29(31-23)40-30(32-34)37-2)38-17-19-9-6-10-24-21(19)11-12-33(24)28(35)18-7-4-3-5-8-18/h3-10,13-16H,11-12,17H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358802
PNG
(US10214544, Example 116)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C30H23FN4O5S/c1-37-20-12-25(22-14-27(40-26(22)13-20)23-15-35-29(32-23)41-30(33-35)38-2)39-16-18-4-3-5-24-21(18)10-11-34(24)28(36)17-6-8-19(31)9-7-17/h3-9,12-15H,10-11,16H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358808
PNG
(US10214544, Example 122)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccccc3C)cc(OC)cc2o1
Show InChI InChI=1S/C31H26N4O5S/c1-18-7-4-5-9-21(18)29(36)34-12-11-22-19(8-6-10-25(22)34)17-39-26-13-20(37-2)14-27-23(26)15-28(40-27)24-16-35-30(32-24)41-31(33-35)38-3/h4-10,13-16H,11-12,17H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358822
PNG
(US10214544, Example 137)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(OC)cc(OC)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H26N4O7S/c1-36-20-9-18(10-21(11-20)37-2)28(35)31-19-7-5-6-17(8-19)16-40-25-12-22(38-3)13-26-23(25)14-27(41-26)24-15-34-29(32-24)42-30(33-34)39-4/h5-15H,16H2,1-4H3,(H,31,35)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358826
PNG
(US10214544, Example 141)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(F)cc4C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H20F4N4O5S/c1-39-18-10-23(20-12-25(42-24(20)11-18)22-13-37-27(35-22)43-28(36-37)40-2)41-14-15-4-3-5-17(8-15)34-26(38)19-7-6-16(30)9-21(19)29(31,32)33/h3-13H,14H2,1-2H3,(H,34,38)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358831
PNG
(US10214544, Example 146)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)CC4CCCCC4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H30N4O5S/c1-35-21-13-24(22-15-26(38-25(22)14-21)23-16-33-28(31-23)39-29(32-33)36-2)37-17-19-9-6-10-20(11-19)30-27(34)12-18-7-4-3-5-8-18/h6,9-11,13-16,18H,3-5,7-8,12,17H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358836
PNG
(US10214544, Example 151)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(Cl)c4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20ClFN4O5S/c1-36-17-10-22(19-12-24(39-23(19)11-17)21-13-34-27(32-21)40-28(33-34)37-2)38-14-15-5-3-6-16(9-15)31-26(35)18-7-4-8-20(29)25(18)30/h3-13H,14H2,1-2H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358846
PNG
(US10214544, Example 161)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(c(F)c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H20F4N4O5S/c1-39-18-10-23(19-12-25(42-24(19)11-18)22-13-37-27(35-22)43-28(36-37)40-2)41-14-15-4-3-5-17(8-15)34-26(38)16-6-7-20(21(30)9-16)29(31,32)33/h3-13H,14H2,1-2H3,(H,34,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358850
PNG
(US10214544, Example 165)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)C4CCOCC4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H26N4O6S/c1-33-19-11-22(36-15-16-4-3-5-18(10-16)28-25(32)17-6-8-35-9-7-17)20-13-24(37-23(20)12-19)21-14-31-26(29-21)38-27(30-31)34-2/h3-5,10-14,17H,6-9,15H2,1-2H3,(H,28,32)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358160
PNG
(4-Fluoro-N-(3-(((6-methoxy-2-(2-methoxyimidazo[2,1...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(F)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21FN4O5S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-4-3-5-19(10-16)30-26(34)17-6-8-18(29)9-7-17/h3-14H,15H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358187
PNG
(N-(3-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(OC(F)(F)F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21F3N4O6S/c1-38-20-11-23(21-13-25(41-24(21)12-20)22-14-36-27(34-22)43-28(35-36)39-2)40-15-16-5-3-7-18(9-16)33-26(37)17-6-4-8-19(10-17)42-29(30,31)32/h3-14H,15H2,1-2H3,(H,33,37)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358194
PNG
(US10214544, Example 9)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(ccc4C(F)(F)F)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H20F6N4O5S/c1-42-18-10-23(20-12-25(45-24(20)11-18)22-13-40-27(38-22)46-28(39-40)43-2)44-14-15-4-3-5-17(8-15)37-26(41)19-9-16(29(31,32)33)6-7-21(19)30(34,35)36/h3-13H,14H2,1-2H3,(H,37,41)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358221
PNG
(US10214544, Example 15)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc5ccccc45)c3)cc(OC)cc2o1
Show InChI InChI=1S/C32H24N4O5S/c1-38-22-14-27(25-16-29(41-28(25)15-22)26-17-36-31(34-26)42-32(35-36)39-2)40-18-19-7-5-10-21(13-19)33-30(37)24-12-6-9-20-8-3-4-11-23(20)24/h3-17H,18H2,1-2H3,(H,33,37)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358465
PNG
(US10214544, Example 30)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(F)c(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H20F4N4O5S/c1-39-18-10-23(19-12-25(42-24(19)11-18)22-13-37-27(35-22)43-28(36-37)40-2)41-14-15-4-3-5-17(8-15)34-26(38)16-6-7-21(30)20(9-16)29(31,32)33/h3-13H,14H2,1-2H3,(H,34,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358491
PNG
(US10214544, Example 36)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(cc4)C#N)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21N5O5S/c1-36-21-11-24(22-13-26(39-25(22)12-21)23-15-34-28(32-23)40-29(33-34)37-2)38-16-18-4-3-5-20(10-18)31-27(35)19-8-6-17(14-30)7-9-19/h3-13,15H,16H2,1-2H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358503
PNG
(US10214544, Example 39)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(I)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21IN4O5S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-4-3-5-19(10-16)30-26(34)17-6-8-18(29)9-7-17/h3-14H,15H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358521
PNG
(US10214544, Example 155 | US10214544, Example 44)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccno4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C25H19N5O6S/c1-32-16-9-20(34-13-14-4-3-5-15(8-14)27-23(31)19-6-7-26-36-19)17-11-22(35-21(17)10-16)18-12-30-24(28-18)37-25(29-30)33-2/h3-12H,13H2,1-2H3,(H,27,31)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358562
PNG
(US10214544, Example 56)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccnc(O)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21N5O6S/c1-35-18-10-21(19-12-23(38-22(19)11-18)20-13-32-26(30-20)39-27(31-32)36-2)37-14-15-4-3-5-17(8-15)29-25(34)16-6-7-28-24(33)9-16/h3-13H,14H2,1-2H3,(H,28,33)(H,29,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358565
PNG
(US10214544, Example 57)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cncnc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H20N6O5S/c1-34-18-7-21(36-13-15-4-3-5-17(6-15)29-24(33)16-10-27-14-28-11-16)19-9-23(37-22(19)8-18)20-12-32-25(30-20)38-26(31-32)35-2/h3-12,14H,13H2,1-2H3,(H,29,33)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358762
PNG
(US10214544, Example 67)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(Cl)cc(OCc5ccccc5)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C35H27ClN4O6S/c1-42-26-15-30(28-17-32(46-31(28)16-26)29-18-40-34(38-29)47-35(39-40)43-2)45-20-22-9-6-10-25(11-22)37-33(41)23-12-24(36)14-27(13-23)44-19-21-7-4-3-5-8-21/h3-18H,19-20H2,1-2H3,(H,37,41)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358771
PNG
(US10214544, Example 76)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(F)cc(OC(F)(F)F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H20F4N4O6S/c1-39-19-10-23(21-12-25(42-24(21)11-19)22-13-37-27(35-22)44-28(36-37)40-2)41-14-15-4-3-5-18(6-15)34-26(38)16-7-17(30)9-20(8-16)43-29(31,32)33/h3-13H,14H2,1-2H3,(H,34,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358773
PNG
(US10214544, Example 78)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(OC)cc(OC(F)F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H24F2N4O7S/c1-38-19-8-17(9-21(10-19)42-28(31)32)27(37)33-18-6-4-5-16(7-18)15-41-24-11-20(39-2)12-25-22(24)13-26(43-25)23-14-36-29(34-23)44-30(35-36)40-3/h4-14,28H,15H2,1-3H3,(H,33,37)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358806
PNG
(US10214544, Example 120)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccccc3F)cc(OC)cc2o1
Show InChI InChI=1S/C30H23FN4O5S/c1-37-18-12-25(21-14-27(40-26(21)13-18)23-15-35-29(32-23)41-30(33-35)38-2)39-16-17-6-5-9-24-19(17)10-11-34(24)28(36)20-7-3-4-8-22(20)31/h3-9,12-15H,10-11,16H2,1-2H3
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358810
PNG
(US10214544, Example 124)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccccc3OC)cc(OC)cc2o1
Show InChI InChI=1S/C31H26N4O6S/c1-37-19-13-26(22-15-28(41-27(22)14-19)23-16-35-30(32-23)42-31(33-35)39-3)40-17-18-7-6-9-24-20(18)11-12-34(24)29(36)21-8-4-5-10-25(21)38-2/h4-10,13-16H,11-12,17H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358812
PNG
(US10214544, Example 126)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3cncnc3)cc(OC)cc2o1
Show InChI InChI=1S/C28H22N6O5S/c1-36-18-8-23(20-10-25(39-24(20)9-18)21-13-34-27(31-21)40-28(32-34)37-2)38-14-16-4-3-5-22-19(16)6-7-33(22)26(35)17-11-29-15-30-12-17/h3-5,8-13,15H,6-7,14H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358815
PNG
(US10214544, Example 129)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3sc(C)nc3C)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N5O5S2/c1-15-26(40-16(2)30-15)27(35)33-9-8-19-17(6-5-7-22(19)33)14-38-23-10-18(36-3)11-24-20(23)12-25(39-24)21-13-34-28(31-21)41-29(32-34)37-4/h5-7,10-13H,8-9,14H2,1-4H3
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n/an/an/an/a 4.20n/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358819
PNG
(US10214544, Example 134)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccco4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H20N4O6S/c1-32-17-10-21(35-14-15-5-3-6-16(9-15)27-24(31)20-7-4-8-34-20)18-12-23(36-22(18)11-17)19-13-30-25(28-19)37-26(29-30)33-2/h3-13H,14H2,1-2H3,(H,27,31)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358821
PNG
(US10214544, Example 136)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)C(C)C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C25H24N4O5S/c1-14(2)23(30)26-16-7-5-6-15(8-16)13-33-20-9-17(31-3)10-21-18(20)11-22(34-21)19-12-29-24(27-19)35-25(28-29)32-4/h5-12,14H,13H2,1-4H3,(H,26,30)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358824
PNG
(US10214544, Example 139)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccn4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21N5O5S/c1-34-18-11-22(36-15-16-6-5-7-17(10-16)29-25(33)20-8-3-4-9-28-20)19-13-24(37-23(19)12-18)21-14-32-26(30-21)38-27(31-32)35-2/h3-14H,15H2,1-2H3,(H,29,33)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358830
PNG
(US10214544, Example 145)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)C4CCCC4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H26N4O5S/c1-33-19-11-22(35-15-16-6-5-9-18(10-16)28-25(32)17-7-3-4-8-17)20-13-24(36-23(20)12-19)21-14-31-26(29-21)37-27(30-31)34-2/h5-6,9-14,17H,3-4,7-8,15H2,1-2H3,(H,28,32)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358843
PNG
(US10214544, Example 158)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(c4)-c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C34H26N4O5S/c1-40-26-16-29(27-18-31(43-30(27)17-26)28-19-38-33(36-28)44-34(37-38)41-2)42-20-21-8-6-13-25(14-21)35-32(39)24-12-7-11-23(15-24)22-9-4-3-5-10-22/h3-19H,20H2,1-2H3,(H,35,39)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358193
PNG
(US10214544, Example 8)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4OC(C)=O)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H24N4O7S/c1-17(35)40-24-10-5-4-9-21(24)28(36)31-19-8-6-7-18(11-19)16-39-25-12-20(37-2)13-26-22(25)14-27(41-26)23-15-34-29(32-23)42-30(33-34)38-3/h4-15H,16H2,1-3H3,(H,31,36)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358259
PNG
(US10214544, Example 20)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(C)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O5S/c1-17-6-4-8-19(10-17)27(34)30-20-9-5-7-18(11-20)16-37-24-12-21(35-2)13-25-22(24)14-26(38-25)23-15-33-28(31-23)39-29(32-33)36-3/h4-15H,16H2,1-3H3,(H,30,34)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358522
PNG
(US10214544, Example 45)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4c(C)noc4C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H23N5O6S/c1-14-24(15(2)38-31-14)25(33)28-17-7-5-6-16(8-17)13-36-21-9-18(34-3)10-22-19(21)11-23(37-22)20-12-32-26(29-20)39-27(30-32)35-4/h5-12H,13H2,1-4H3,(H,28,33)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358567
PNG
(US10214544, Example 59)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4c(C)noc4-c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C32H25N5O6S/c1-18-28(29(43-36-18)20-9-5-4-6-10-20)30(38)33-21-11-7-8-19(12-21)17-41-25-13-22(39-2)14-26-23(25)15-27(42-26)24-16-37-31(34-24)44-32(35-37)40-3/h4-16H,17H2,1-3H3,(H,33,38)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358768
PNG
(US10214544, Example 73)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(C)nc4O)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N5O6S/c1-15-7-8-19(25(34)29-15)26(35)30-17-6-4-5-16(9-17)14-38-22-10-18(36-2)11-23-20(22)12-24(39-23)21-13-33-27(31-21)40-28(32-33)37-3/h4-13H,14H2,1-3H3,(H,29,34)(H,30,35)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358770
PNG
(US10214544, Example 75)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(F)ccc4C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H23FN4O5S/c1-16-7-8-18(30)10-21(16)27(35)31-19-6-4-5-17(9-19)15-38-24-11-20(36-2)12-25-22(24)13-26(39-25)23-14-34-28(32-23)40-29(33-34)37-3/h4-14H,15H2,1-3H3,(H,31,35)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358794
PNG
(US10214544, Example 105)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5ccc(C)cc5)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H26N4O5S/c1-18-4-7-21(8-5-18)29(36)34-11-10-20-9-6-19(12-25(20)34)17-39-26-13-22(37-2)14-27-23(26)15-28(40-27)24-16-35-30(32-24)41-31(33-35)38-3/h4-9,12-16H,10-11,17H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358809
PNG
(US10214544, Example 123)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccc(C)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C31H26N4O5S/c1-18-7-9-19(10-8-18)29(36)34-12-11-22-20(5-4-6-25(22)34)17-39-26-13-21(37-2)14-27-23(26)15-28(40-27)24-16-35-30(32-24)41-31(33-35)38-3/h4-10,13-16H,11-12,17H2,1-3H3
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358818
PNG
(US10214544, Example 133)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cnccn4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H20N6O5S/c1-34-17-9-21(36-14-15-4-3-5-16(8-15)29-24(33)19-12-27-6-7-28-19)18-11-23(37-22(18)10-17)20-13-32-25(30-20)38-26(31-32)35-2/h3-13H,14H2,1-2H3,(H,29,33)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358834
PNG
(US10214544, Example 149)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21F3N4O5S/c1-38-20-11-23(21-13-25(41-24(21)12-20)22-14-36-27(34-22)42-28(35-36)39-2)40-15-16-5-3-8-19(9-16)33-26(37)17-6-4-7-18(10-17)29(30,31)32/h3-14H,15H2,1-2H3,(H,33,37)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358837
PNG
(US10214544, Example 152)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(F)cc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F2N4O5S/c1-36-18-10-23(20-12-25(39-24(20)11-18)22-13-34-27(32-22)40-28(33-34)37-2)38-14-15-4-3-5-17(8-15)31-26(35)19-7-6-16(29)9-21(19)30/h3-13H,14H2,1-2H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358177
PNG
(3-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]th...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(N)c3)cc(OC)cc2o1
Show InChI InChI=1S/C21H18N4O4S/c1-26-14-7-17(28-11-12-4-3-5-13(22)6-12)15-9-19(29-18(15)8-14)16-10-25-20(23-16)30-21(24-25)27-2/h3-10H,11,22H2,1-2H3
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358233
PNG
(US10214544, Example 17)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)COCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H26N4O6S/c1-36-22-12-25(23-14-27(40-26(23)13-22)24-15-34-29(32-24)41-30(33-34)37-2)39-17-20-9-6-10-21(11-20)31-28(35)18-38-16-19-7-4-3-5-8-19/h3-15H,16-18H2,1-2H3,(H,31,35)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358255
PNG
(US10214544, Example 19)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(Cl)cc(Cl)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20Cl2N4O5S/c1-36-20-10-23(21-12-25(39-24(21)11-20)22-13-34-27(32-22)40-28(33-34)37-2)38-14-15-4-3-5-19(6-15)31-26(35)16-7-17(29)9-18(30)8-16/h3-13H,14H2,1-2H3,(H,31,35)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358504
PNG
(US10214544, Example 40)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)C(C)(C)Oc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H28N4O6S/c1-31(2,41-21-11-6-5-7-12-21)28(36)32-20-10-8-9-19(13-20)18-39-25-14-22(37-3)15-26-23(25)16-27(40-26)24-17-35-29(33-24)42-30(34-35)38-4/h5-17H,18H2,1-4H3,(H,32,36)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358541
PNG
(US10214544, Example 47)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)Cc4cc(C)no4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H23N5O6S/c1-15-7-19(38-31-15)11-25(33)28-17-6-4-5-16(8-17)14-36-22-9-18(34-2)10-23-20(22)12-24(37-23)21-13-32-26(29-21)39-27(30-32)35-3/h4-10,12-13H,11,14H2,1-3H3,(H,28,33)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358551
PNG
(US10214544, Example 51)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(Oc5ccccc5)nc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C33H25N5O6S/c1-40-24-14-27(25-16-29(44-28(25)15-24)26-18-38-32(36-26)45-33(37-38)41-2)42-19-20-7-6-8-22(13-20)35-31(39)21-11-12-30(34-17-21)43-23-9-4-3-5-10-23/h3-18H,19H2,1-2H3,(H,35,39)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358757
PNG
(US10214544, Example 62)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(OCc5ccccc5)cc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C36H27F3N4O6S/c1-45-26-15-30(28-17-32(49-31(28)16-26)29-18-43-34(41-29)50-35(42-43)46-2)48-20-22-9-6-10-25(11-22)40-33(44)23-12-24(36(37,38)39)14-27(13-23)47-19-21-7-4-3-5-8-21/h3-18H,19-20H2,1-2H3,(H,40,44)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358766
PNG
(US10214544, Example 71)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(C)cc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H23F3N4O5S/c1-16-7-18(10-19(8-16)30(31,32)33)27(38)34-20-6-4-5-17(9-20)15-41-24-11-21(39-2)12-25-22(24)13-26(42-25)23-14-37-28(35-23)43-29(36-37)40-3/h4-14H,15H2,1-3H3,(H,34,38)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358767
PNG
(US10214544, Example 72)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4csc(n4)-c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H23N5O5S2/c1-38-21-12-25(22-14-27(41-26(22)13-21)23-15-36-30(34-23)43-31(35-36)39-2)40-16-18-7-6-10-20(11-18)32-28(37)24-17-42-29(33-24)19-8-4-3-5-9-19/h3-15,17H,16H2,1-2H3,(H,32,37)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358778
PNG
(US10214544, Example 84)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3ccccc3C)cc(OC)cc2o1
Show InChI InChI=1S/C30H26N4O5S/c1-18-8-5-6-11-22(18)28(35)33(2)20-10-7-9-19(12-20)17-38-25-13-21(36-3)14-26-23(25)15-27(39-26)24-16-34-29(31-24)40-30(32-34)37-4/h5-16H,17H2,1-4H3
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358790
PNG
(US10214544, Example 101)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5ccccc5C)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H26N4O5S/c1-18-6-4-5-7-22(18)29(36)34-11-10-20-9-8-19(12-25(20)34)17-39-26-13-21(37-2)14-27-23(26)15-28(40-27)24-16-35-30(32-24)41-31(33-35)38-3/h4-9,12-16H,10-11,17H2,1-3H3
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358793
PNG
(US10214544, Example 104)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5ccccc5F)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H23FN4O5S/c1-37-19-12-25(21-14-27(40-26(21)13-19)23-15-35-29(32-23)41-30(33-35)38-2)39-16-17-7-8-18-9-10-34(24(18)11-17)28(36)20-5-3-4-6-22(20)31/h3-8,11-15H,9-10,16H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358804
PNG
(US10214544, Example 118)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3csc(n3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F3N5O5S2/c1-38-15-8-21(17-10-23(41-22(17)9-15)18-11-36-26(33-18)43-27(34-36)39-2)40-12-14-4-3-5-20-16(14)6-7-35(20)24(37)19-13-42-25(32-19)28(29,30)31/h3-5,8-11,13H,6-7,12H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358811
PNG
(US10214544, Example 125)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3cc(C)cc(c3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C32H25F3N4O5S/c1-17-9-19(11-20(10-17)32(33,34)35)29(40)38-8-7-22-18(5-4-6-25(22)38)16-43-26-12-21(41-2)13-27-23(26)14-28(44-27)24-15-39-30(36-24)45-31(37-39)42-3/h4-6,9-15H,7-8,16H2,1-3H3
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358829
PNG
(US10214544, Example 144)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(c4)N(C)C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H27N5O5S/c1-34(2)21-10-6-8-19(12-21)28(36)31-20-9-5-7-18(11-20)17-39-25-13-22(37-3)14-26-23(25)15-27(40-26)24-16-35-29(32-24)41-30(33-35)38-4/h5-16H,17H2,1-4H3,(H,31,36)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358842
PNG
(US10214544, Example 157)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(OC)c(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H23F3N4O6S/c1-39-19-11-24(20-13-26(43-25(20)12-19)22-14-37-28(35-22)44-29(36-37)41-3)42-15-16-5-4-6-18(9-16)34-27(38)17-7-8-23(40-2)21(10-17)30(31,32)33/h4-14H,15H2,1-3H3,(H,34,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358183
PNG
(4-Chloro-N-(3-(((6-methoxy-2-(2-methoxyimidazo[2,1...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(Cl)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21ClN4O5S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-4-3-5-19(10-16)30-26(34)17-6-8-18(29)9-7-17/h3-14H,15H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358198
PNG
(US10214544, Example 11)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(Cl)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21ClN4O5S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-5-3-8-19(9-16)30-26(34)17-6-4-7-18(29)10-17/h3-14H,15H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358219
PNG
(US10214544, Example 13)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21F3N4O5S/c1-38-18-11-23(20-13-25(41-24(20)12-18)22-14-36-27(34-22)42-28(35-36)39-2)40-15-16-6-5-7-17(10-16)33-26(37)19-8-3-4-9-21(19)29(30,31)32/h3-14H,15H2,1-2H3,(H,33,37)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358265
PNG
(US10214544, Example 22)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc5OCOc5c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H22N4O7S/c1-35-19-10-23(20-12-25(40-24(20)11-19)21-13-33-28(31-21)41-29(32-33)36-2)37-14-16-4-3-5-18(8-16)30-27(34)17-6-7-22-26(9-17)39-15-38-22/h3-13H,14-15H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358408
PNG
(US10214544, Example 26)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21FN4O5S/c1-35-18-11-23(20-13-25(38-24(20)12-18)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-6-5-7-17(10-16)30-26(34)19-8-3-4-9-21(19)29/h3-14H,15H2,1-2H3,(H,30,34)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358561
PNG
(US10214544, Example 55)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(Cl)nc(Cl)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H19Cl2N5O5S/c1-36-17-9-20(18-11-22(39-21(18)10-17)19-12-34-26(31-19)40-27(33-34)37-2)38-13-14-4-3-5-16(6-14)30-25(35)15-7-23(28)32-24(29)8-15/h3-12H,13H2,1-2H3,(H,30,35)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358566
PNG
(US10214544, Example 58)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccnc4Cl)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H20ClN5O5S/c1-35-17-10-21(19-12-23(38-22(19)11-17)20-13-33-26(31-20)39-27(32-33)36-2)37-14-15-5-3-6-16(9-15)30-25(34)18-7-4-8-29-24(18)28/h3-13H,14H2,1-2H3,(H,30,34)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358582
PNG
(US10214544, Example 61)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccnc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H20FN5O5S/c1-35-17-10-21(19-12-23(38-22(19)11-17)20-13-33-26(31-20)39-27(32-33)36-2)37-14-15-5-3-6-16(9-15)30-25(34)18-7-4-8-29-24(18)28/h3-13H,14H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358779
PNG
(US10214544, Example 85)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3cccc(F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H23FN4O5S/c1-33(27(35)18-7-5-8-19(30)11-18)20-9-4-6-17(10-20)16-38-24-12-21(36-2)13-25-22(24)14-26(39-25)23-15-34-28(31-23)40-29(32-34)37-3/h4-15H,16H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358782
PNG
(US10214544, Example 88)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3ccccc3F)cc(OC)cc2o1
Show InChI InChI=1S/C29H23FN4O5S/c1-33(27(35)20-9-4-5-10-22(20)30)18-8-6-7-17(11-18)16-38-24-12-19(36-2)13-25-21(24)14-26(39-25)23-15-34-28(31-23)40-29(32-34)37-3/h4-15H,16H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358786
PNG
(US10214544, Example 92)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3cncnc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N6O5S/c1-32(25(34)17-11-28-15-29-12-17)18-6-4-5-16(7-18)14-37-22-8-19(35-2)9-23-20(22)10-24(38-23)21-13-33-26(30-21)39-27(31-33)36-3/h4-13,15H,14H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358792
PNG
(US10214544, Example 103)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5ccccc5OC)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H26N4O6S/c1-37-20-13-26(22-15-28(41-27(22)14-20)23-16-35-30(32-23)42-31(33-35)39-3)40-17-18-8-9-19-10-11-34(24(19)12-18)29(36)21-6-4-5-7-25(21)38-2/h4-9,12-16H,10-11,17H2,1-3H3
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358795
PNG
(US10214544, Example 106)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5ccc(OC)nc5)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H25N5O6S/c1-37-20-11-24(21-13-26(41-25(21)12-20)22-15-35-29(32-22)42-30(33-35)39-3)40-16-17-4-5-18-8-9-34(23(18)10-17)28(36)19-6-7-27(38-2)31-14-19/h4-7,10-15H,8-9,16H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358798
PNG
(US10214544, Example 111)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5cc(C)cc(c5)C(F)(F)F)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C32H25F3N4O5S/c1-17-8-20(11-21(9-17)32(33,34)35)29(40)38-7-6-19-5-4-18(10-25(19)38)16-43-26-12-22(41-2)13-27-23(26)14-28(44-27)24-15-39-30(36-24)45-31(37-39)42-3/h4-5,8-15H,6-7,16H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358799
PNG
(US10214544, Example 112)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5csc(n5)-c5ccccc5)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C33H25N5O5S2/c1-40-22-13-27(23-15-29(43-28(23)14-22)24-16-38-32(35-24)45-33(36-38)41-2)42-17-19-8-9-20-10-11-37(26(20)12-19)31(39)25-18-44-30(34-25)21-6-4-3-5-7-21/h3-9,12-16,18H,10-11,17H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358814
PNG
(US10214544, Example 128)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccnnc3)cc(OC)cc2o1
Show InChI InChI=1S/C28H22N6O5S/c1-36-18-10-23(20-12-25(39-24(20)11-18)21-14-34-27(31-21)40-28(32-34)37-2)38-15-17-4-3-5-22-19(17)7-9-33(22)26(35)16-6-8-29-30-13-16/h3-6,8,10-14H,7,9,15H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358817
PNG
(US10214544, Example 132)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccn4C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H23N5O5S/c1-31-9-5-8-21(31)25(33)28-17-7-4-6-16(10-17)15-36-22-11-18(34-2)12-23-19(22)13-24(37-23)20-14-32-26(29-20)38-27(30-32)35-3/h4-14H,15H2,1-3H3,(H,28,33)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358832
PNG
(US10214544, Example 147)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4c(F)cccc4C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H20F4N4O5S/c1-39-17-10-22(18-12-24(42-23(18)11-17)21-13-37-27(35-21)43-28(36-37)40-2)41-14-15-5-3-6-16(9-15)34-26(38)25-19(29(31,32)33)7-4-8-20(25)30/h3-13H,14H2,1-2H3,(H,34,38)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358833
PNG
(US10214544, Example 148)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccnc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21N5O5S/c1-34-19-10-22(36-15-16-5-3-7-18(9-16)29-25(33)17-6-4-8-28-13-17)20-12-24(37-23(20)11-19)21-14-32-26(30-21)38-27(31-32)35-2/h3-14H,15H2,1-2H3,(H,29,33)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358844
PNG
(US10214544, Example 159)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(F)cc(F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F2N4O5S/c1-36-20-10-23(21-12-25(39-24(21)11-20)22-13-34-27(32-22)40-28(33-34)37-2)38-14-15-4-3-5-19(6-15)31-26(35)16-7-17(29)9-18(30)8-16/h3-13H,14H2,1-2H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM358851
PNG
(US10214544, Example 166)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(F)c(F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F2N4O5S/c1-36-18-10-23(19-12-25(39-24(19)11-18)22-13-34-27(32-22)40-28(33-34)37-2)38-14-15-4-3-5-17(8-15)31-26(35)16-6-7-20(29)21(30)9-16/h3-13H,14H2,1-2H3,(H,31,35)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10214544 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WNS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%