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Patent code US10214544

Compile Data Set for Download or QSAR
Found 155 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358197
PNG
(US10214544, Example 10)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(Br)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21BrN4O5S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-5-3-8-19(9-16)30-26(34)17-6-4-7-18(29)10-17/h3-14H,15H2,1-2H3,(H,30,34)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.90n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358260
PNG
(US10214544, Example 21)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4c(F)cc(F)cc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H19F3N4O5S/c1-37-17-9-22(18-11-24(40-23(18)10-17)21-12-35-27(33-21)41-28(34-35)38-2)39-13-14-4-3-5-16(6-14)32-26(36)25-19(30)7-15(29)8-20(25)31/h3-12H,13H2,1-2H3,(H,32,36)
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.5n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358266
PNG
(US10214544, Example 23)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc5ccccc5c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C32H24N4O5S/c1-38-24-14-27(25-16-29(41-28(25)15-24)26-17-36-31(34-26)42-32(35-36)39-2)40-18-19-6-5-9-23(12-19)33-30(37)22-11-10-20-7-3-4-8-21(20)13-22/h3-17H,18H2,1-2H3,(H,33,37)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.80n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358343
PNG
(US10214544, Example 25)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4Cl)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21ClN4O5S/c1-35-18-11-23(20-13-25(38-24(20)12-18)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-6-5-7-17(10-16)30-26(34)19-8-3-4-9-21(19)29/h3-14H,15H2,1-2H3,(H,30,34)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.70n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358474
PNG
(US10214544, Example 32)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(C)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O5S/c1-17-7-9-19(10-8-17)27(34)30-20-6-4-5-18(11-20)16-37-24-12-21(35-2)13-25-22(24)14-26(38-25)23-15-33-28(31-23)39-29(32-33)36-3/h4-15H,16H2,1-3H3,(H,30,34)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.60n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358481
PNG
(US10214544, Example 33)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(cc4)[N+]([O-])=O)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21N5O7S/c1-37-20-11-23(21-13-25(40-24(21)12-20)22-14-32-27(30-22)41-28(31-32)38-2)39-15-16-4-3-5-18(10-16)29-26(34)17-6-8-19(9-7-17)33(35)36/h3-14H,15H2,1-2H3,(H,29,34)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.80n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358487
PNG
(US10214544, Example 34)
Show SMILES COC(=O)c1ccc(cc1)C(=O)Nc1cccc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)c1
Show InChI InChI=1S/C30H24N4O7S/c1-37-21-12-24(22-14-26(41-25(22)13-21)23-15-34-29(32-23)42-30(33-34)39-3)40-16-17-5-4-6-20(11-17)31-27(35)18-7-9-19(10-8-18)28(36)38-2/h4-15H,16H2,1-3H3,(H,31,35)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.20n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358496
PNG
(US10214544, Example 37)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(cc4)C(C)(C)C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C32H30N4O5S/c1-32(2,3)21-11-9-20(10-12-21)29(37)33-22-8-6-7-19(13-22)18-40-26-14-23(38-4)15-27-24(26)16-28(41-27)25-17-36-30(34-25)42-31(35-36)39-5/h6-17H,18H2,1-5H3,(H,33,37)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.5n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358763
PNG
(US10214544, Example 68)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cn5nc(sc5n4)C(C)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21F2N7O5S2/c1-28(29,30)24-34-36-12-19(33-25(36)43-24)23(38)31-15-6-4-5-14(7-15)13-41-20-8-16(39-2)9-21-17(20)10-22(42-21)18-11-37-26(32-18)44-27(35-37)40-3/h4-12H,13H2,1-3H3,(H,31,38)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.90n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358765
PNG
(US10214544, Example 70)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4csc(n4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H18F3N5O5S2/c1-36-15-7-19(16-9-21(39-20(16)8-15)17-10-34-24(32-17)41-25(33-34)37-2)38-11-13-4-3-5-14(6-13)30-22(35)18-12-40-23(31-18)26(27,28)29/h3-10,12H,11H2,1-2H3,(H,30,35)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358769
PNG
(US10214544, Example 74)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(OC(F)F)cc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H21F5N4O6S/c1-41-19-10-23(21-12-25(45-24(21)11-19)22-13-39-28(37-22)46-29(38-39)42-2)43-14-15-4-3-5-18(6-15)36-26(40)16-7-17(30(33,34)35)9-20(8-16)44-27(31)32/h3-13,27H,14H2,1-2H3,(H,36,40)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.950n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358780
PNG
(US10214544, Example 86)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3ccccc3OC)cc(OC)cc2o1
Show InChI InChI=1S/C30H26N4O6S/c1-33(28(35)21-10-5-6-11-24(21)37-3)19-9-7-8-18(12-19)17-39-25-13-20(36-2)14-26-22(25)15-27(40-26)23-16-34-29(31-23)41-30(32-34)38-4/h5-16H,17H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.80n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358784
PNG
(US10214544, Example 90)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3ccc(OC)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N5O6S/c1-33(27(35)18-8-9-26(37-3)30-14-18)19-7-5-6-17(10-19)16-39-23-11-20(36-2)12-24-21(23)13-25(40-24)22-15-34-28(31-22)41-29(32-34)38-4/h5-15H,16H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.10n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358788
PNG
(US10214544, Example 94)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(C)=O)cc(OC)cc2o1
Show InChI InChI=1S/C24H22N4O5S/c1-14(29)27(2)16-7-5-6-15(8-16)13-32-20-9-17(30-3)10-21-18(20)11-22(33-21)19-12-28-23(25-19)34-24(26-28)31-4/h5-12H,13H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.80n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358789
PNG
(US10214544, Example 97)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C=O)cc(OC)cc2o1
Show InChI InChI=1S/C23H20N4O5S/c1-26(13-28)15-6-4-5-14(7-15)12-31-19-8-16(29-2)9-20-17(19)10-21(32-20)18-11-27-22(24-18)33-23(25-27)30-3/h4-11,13H,12H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.5n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358796
PNG
(US10214544, Example 107)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(C)=O)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C25H22N4O5S/c1-14(30)28-7-6-16-5-4-15(8-20(16)28)13-33-21-9-17(31-2)10-22-18(21)11-23(34-22)19-12-29-24(26-19)35-25(27-29)32-3/h4-5,8-12H,6-7,13H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 26n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358813
PNG
(US10214544, Example 127)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccc(OC)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C30H25N5O6S/c1-37-19-11-24(21-13-26(41-25(21)12-19)22-15-35-29(32-22)42-30(33-35)39-3)40-16-18-5-4-6-23-20(18)9-10-34(23)28(36)17-7-8-27(38-2)31-14-17/h4-8,11-15H,9-10,16H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.90n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358823
PNG
(US10214544, Example 138)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)CC4CCCC4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H28N4O5S/c1-34-20-12-23(36-16-18-8-5-9-19(10-18)29-26(33)11-17-6-3-4-7-17)21-14-25(37-24(21)13-20)22-15-32-27(30-22)38-28(31-32)35-2/h5,8-10,12-15,17H,3-4,6-7,11,16H2,1-2H3,(H,29,33)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.5n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358835
PNG
(US10214544, Example 150)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)C4CCCCC4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H28N4O5S/c1-34-20-12-23(36-16-17-7-6-10-19(11-17)29-26(33)18-8-4-3-5-9-18)21-14-25(37-24(21)13-20)22-15-32-27(30-22)38-28(31-32)35-2/h6-7,10-15,18H,3-5,8-9,16H2,1-2H3,(H,29,33)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.30n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358838
PNG
(US10214544, Example 153)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(cc4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21F3N4O5S/c1-38-20-11-23(21-13-25(41-24(21)12-20)22-14-36-27(34-22)42-28(35-36)39-2)40-15-16-4-3-5-19(10-16)33-26(37)17-6-8-18(9-7-17)29(30,31)32/h3-14H,15H2,1-2H3,(H,33,37)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.990n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358839
PNG
(US10214544, Example 154)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(F)ccc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F2N4O5S/c1-36-18-10-23(20-12-25(39-24(20)11-18)22-13-34-27(32-22)40-28(33-34)37-2)38-14-15-4-3-5-17(8-15)31-26(35)19-9-16(29)6-7-21(19)30/h3-13H,14H2,1-2H3,(H,31,35)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.20n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358521
PNG
(US10214544, Example 155 | US10214544, Example 44)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccno4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C25H19N5O6S/c1-32-16-9-20(34-13-14-4-3-5-15(8-14)27-23(31)19-6-7-26-36-19)17-11-22(35-21(17)10-16)18-12-30-24(28-18)37-25(29-30)33-2/h3-12H,13H2,1-2H3,(H,27,31)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358845
PNG
(US10214544, Example 160)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(OC)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O6S/c1-35-20-9-5-7-18(11-20)27(34)30-19-8-4-6-17(10-19)16-38-24-12-21(36-2)13-25-22(24)14-26(39-25)23-15-33-28(31-23)40-29(32-33)37-3/h4-15H,16H2,1-3H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358847
PNG
(US10214544, Example 162)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4c(OC)cccc4OC)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H26N4O7S/c1-36-19-12-24(20-14-26(41-25(20)13-19)21-15-34-29(32-21)42-30(33-34)39-4)40-16-17-7-5-8-18(11-17)31-28(35)27-22(37-2)9-6-10-23(27)38-3/h5-15H,16H2,1-4H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358156
PNG
(N-(3-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H22N4O5S/c1-34-20-12-23(36-16-17-7-6-10-19(11-17)29-26(33)18-8-4-3-5-9-18)21-14-25(37-24(21)13-20)22-15-32-27(30-22)38-28(31-32)35-2/h3-15H,16H2,1-2H3,(H,29,33)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358202
PNG
(US10214544, Example 12)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4c(Cl)cccc4Cl)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20Cl2N4O5S/c1-36-17-10-22(18-12-24(39-23(18)11-17)21-13-34-27(32-21)40-28(33-34)37-2)38-14-15-5-3-6-16(9-15)31-26(35)25-19(29)7-4-8-20(25)30/h3-13H,14H2,1-2H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358523
PNG
(US10214544, Example 46)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(OC)nc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N5O6S/c1-35-19-10-22(20-12-24(39-23(20)11-19)21-14-33-27(31-21)40-28(32-33)37-3)38-15-16-5-4-6-18(9-16)30-26(34)17-7-8-25(36-2)29-13-17/h4-14H,15H2,1-3H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358548
PNG
(US10214544, Example 49)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)Cc4nc(C)sc4C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H25N5O5S2/c1-15-21(29-16(2)39-15)12-26(34)30-18-7-5-6-17(8-18)14-37-23-9-19(35-3)10-24-20(23)11-25(38-24)22-13-33-27(31-22)40-28(32-33)36-4/h5-11,13H,12,14H2,1-4H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358560
PNG
(US10214544, Example 53)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(Cl)nc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H20ClN5O5S/c1-35-18-9-21(19-11-23(38-22(19)10-18)20-13-33-26(31-20)39-27(32-33)36-2)37-14-15-4-3-5-17(8-15)30-25(34)16-6-7-24(28)29-12-16/h3-13H,14H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358580
PNG
(US10214544, Example 60)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cnoc4-c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H23N5O6S/c1-38-21-12-25(22-14-27(41-26(22)13-21)24-16-36-30(34-24)43-31(35-36)39-2)40-17-18-7-6-10-20(11-18)33-29(37)23-15-32-42-28(23)19-8-4-3-5-9-19/h3-16H,17H2,1-2H3,(H,33,37)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358759
PNG
(US10214544, Example 64)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(C)nc4Cl)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H22ClN5O5S/c1-15-7-8-19(25(29)30-15)26(35)31-17-6-4-5-16(9-17)14-38-22-10-18(36-2)11-23-20(22)12-24(39-23)21-13-34-27(32-21)40-28(33-34)37-3/h4-13H,14H2,1-3H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358760
PNG
(US10214544, Example 65)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(Br)cn4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H20BrN5O5S/c1-35-18-9-22(19-11-24(38-23(19)10-18)21-13-33-26(31-21)39-27(32-33)36-2)37-14-15-4-3-5-17(8-15)30-25(34)20-7-6-16(28)12-29-20/h3-13H,14H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358764
PNG
(US10214544, Example 69)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccnnc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H20N6O5S/c1-34-18-9-21(36-14-15-4-3-5-17(8-15)29-24(33)16-6-7-27-28-12-16)19-11-23(37-22(19)10-18)20-13-32-25(30-20)38-26(31-32)35-2/h3-13H,14H2,1-2H3,(H,29,33)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358783
PNG
(US10214544, Example 89)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3ccc(C)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C30H26N4O5S/c1-18-8-10-20(11-9-18)28(35)33(2)21-7-5-6-19(12-21)17-38-25-13-22(36-3)14-26-23(25)15-27(39-26)24-16-34-29(31-24)40-30(32-34)37-4/h5-16H,17H2,1-4H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358797
PNG
(US10214544, Example 110)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5csc(n5)C(F)(F)F)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F3N5O5S2/c1-38-16-8-21(17-10-23(41-22(17)9-16)18-11-36-26(33-18)43-27(34-36)39-2)40-12-14-3-4-15-5-6-35(20(15)7-14)24(37)19-13-42-25(32-19)28(29,30)31/h3-4,7-11,13H,5-6,12H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358803
PNG
(US10214544, Example 117)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(C)=O)cc(OC)cc2o1
Show InChI InChI=1S/C25H22N4O5S/c1-14(30)28-8-7-17-15(5-4-6-20(17)28)13-33-21-9-16(31-2)10-22-18(21)11-23(34-22)19-12-29-24(26-19)35-25(27-29)32-3/h4-6,9-12H,7-8,13H2,1-3H3
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Universite De Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358807
PNG
(US10214544, Example 121)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3cccc(F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H23FN4O5S/c1-37-20-12-25(22-14-27(40-26(22)13-20)23-15-35-29(32-23)41-30(33-35)38-2)39-16-18-6-4-8-24-21(18)9-10-34(24)28(36)17-5-3-7-19(31)11-17/h3-8,11-15H,9-10,16H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358825
PNG
(US10214544, Example 140)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(ccc4F)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H20F4N4O5S/c1-39-18-10-23(20-12-25(42-24(20)11-18)22-13-37-27(35-22)43-28(36-37)40-2)41-14-15-4-3-5-17(8-15)34-26(38)19-9-16(29(31,32)33)6-7-21(19)30/h3-13H,14H2,1-2H3,(H,34,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358828
PNG
(US10214544, Example 143)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4c(F)cccc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F2N4O5S/c1-36-17-10-22(18-12-24(39-23(18)11-17)21-13-34-27(32-21)40-28(33-34)37-2)38-14-15-5-3-6-16(9-15)31-26(35)25-19(29)7-4-8-20(25)30/h3-13H,14H2,1-2H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358841
PNG
(US10214544, Example 156)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(Cl)c4Cl)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20Cl2N4O5S/c1-36-17-10-22(19-12-24(39-23(19)11-17)21-13-34-27(32-21)40-28(33-34)37-2)38-14-15-5-3-6-16(9-15)31-26(35)18-7-4-8-20(29)25(18)30/h3-13H,14H2,1-2H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358849
PNG
(US10214544, Example 164)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(OC(F)F)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H22F2N4O6S/c1-37-20-11-23(21-13-25(41-24(21)12-20)22-14-35-28(33-22)42-29(34-35)38-2)39-15-16-4-3-5-18(10-16)32-26(36)17-6-8-19(9-7-17)40-27(30)31/h3-14,27H,15H2,1-2H3,(H,32,36)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358220
PNG
(US10214544, Example 14)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(F)c(F)c4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H19F3N4O5S/c1-37-16-9-21(18-11-23(40-22(18)10-16)20-12-35-27(33-20)41-28(34-35)38-2)39-13-14-4-3-5-15(8-14)32-26(36)17-6-7-19(29)25(31)24(17)30/h3-12H,13H2,1-2H3,(H,32,36)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358234
PNG
(US10214544, Example 18)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(OC)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O6S/c1-35-20-9-7-18(8-10-20)27(34)30-19-6-4-5-17(11-19)16-38-24-12-21(36-2)13-25-22(24)14-26(39-25)23-15-33-28(31-23)40-29(32-33)37-3/h4-15H,16H2,1-3H3,(H,30,34)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358497
PNG
(US10214544, Example 38)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)NCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N5O5S/c1-36-21-12-24(22-14-26(39-25(22)13-21)23-16-34-28(32-23)40-29(33-34)37-2)38-17-19-9-6-10-20(11-19)31-27(35)30-15-18-7-4-3-5-8-18/h3-14,16H,15,17H2,1-2H3,(H2,30,31,35)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358508
PNG
(US10214544, Example 41)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(OC(F)(F)F)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21F3N4O6S/c1-38-20-11-23(21-13-25(41-24(21)12-20)22-14-36-27(34-22)43-28(35-36)39-2)40-15-16-4-3-5-18(10-16)33-26(37)17-6-8-19(9-7-17)42-29(30,31)32/h3-14H,15H2,1-2H3,(H,33,37)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358510
PNG
(US10214544, Example 42)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(OC)cc4OC)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H26N4O7S/c1-36-19-8-9-21(24(11-19)38-3)28(35)31-18-7-5-6-17(10-18)16-40-25-12-20(37-2)13-26-22(25)14-27(41-26)23-15-34-29(32-23)42-30(33-34)39-4/h5-15H,16H2,1-4H3,(H,31,35)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358517
PNG
(US10214544, Example 43)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(cc4)N(C)C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H27N5O5S/c1-34(2)21-10-8-19(9-11-21)28(36)31-20-7-5-6-18(12-20)17-39-25-13-22(37-3)14-26-23(25)15-27(40-26)24-16-35-29(32-24)41-30(33-35)38-4/h5-16H,17H2,1-4H3,(H,31,36)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358552
PNG
(US10214544, Example 52)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4)c3)cccc2o1
Show InChI InChI=1S/C27H20N4O4S/c1-33-27-30-31-15-21(29-26(31)36-27)24-14-20-22(11-6-12-23(20)35-24)34-16-17-7-5-10-19(13-17)28-25(32)18-8-3-2-4-9-18/h2-15H,16H2,1H3,(H,28,32)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358761
PNG
(US10214544, Example 66)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cnc(nc4C)-c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C33H26N6O5S/c1-19-25(16-34-30(35-19)21-9-5-4-6-10-21)31(40)36-22-11-7-8-20(12-22)18-43-27-13-23(41-2)14-28-24(27)15-29(44-28)26-17-39-32(37-26)45-33(38-39)42-3/h4-17H,18H2,1-3H3,(H,36,40)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358774
PNG
(US10214544, Example 80)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4csc(n4)-c4cccc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C32H22F3N5O5S2/c1-42-21-11-25(22-13-27(45-26(22)12-21)23-14-40-30(38-23)47-31(39-40)43-2)44-15-17-5-3-8-20(9-17)36-28(41)24-16-46-29(37-24)18-6-4-7-19(10-18)32(33,34)35/h3-14,16H,15H2,1-2H3,(H,36,41)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358775
PNG
(US10214544, Example 81 | tert-Butyl (3-(((6-methox...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)OC(C)(C)C)cc(OC)cc2o1
Show InChI InChI=1S/C27H28N4O6S/c1-27(2,3)37-26(32)30(4)17-9-7-8-16(10-17)15-35-21-11-18(33-5)12-22-19(21)13-23(36-22)20-14-31-24(28-20)38-25(29-31)34-6/h7-14H,15H2,1-6H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358787
PNG
(US10214544, Example 93)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3sc(C)nc3C)cc(OC)cc2o1
Show InChI InChI=1S/C28H25N5O5S2/c1-15-25(39-16(2)29-15)26(34)32(3)18-8-6-7-17(9-18)14-37-22-10-19(35-4)11-23-20(22)12-24(38-23)21-13-33-27(30-21)40-28(31-33)36-5/h6-13H,14H2,1-5H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358791
PNG
(US10214544, Example 102)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5cccc(F)c5)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H23FN4O5S/c1-37-21-12-25(22-14-27(40-26(22)13-21)23-15-35-29(32-23)41-30(33-35)38-2)39-16-17-6-7-18-8-9-34(24(18)10-17)28(36)19-4-3-5-20(31)11-19/h3-7,10-15H,8-9,16H2,1-2H3
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358800
PNG
(6-(4-(Indolin-4-ylmethoxy)-6-methoxybenzofuran-2-y...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4NCCc34)cc(OC)cc2o1
Show InChI InChI=1S/C23H20N4O4S/c1-28-14-8-19(30-12-13-4-3-5-17-15(13)6-7-24-17)16-10-21(31-20(16)9-14)18-11-27-22(25-18)32-23(26-27)29-2/h3-5,8-11,24H,6-7,12H2,1-2H3
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358805
PNG
(US10214544, Example 119)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3csc(n3)-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C33H25N5O5S2/c1-40-21-13-27(23-15-29(43-28(23)14-21)24-16-38-32(35-24)45-33(36-38)41-2)42-17-20-9-6-10-26-22(20)11-12-37(26)31(39)25-18-44-30(34-25)19-7-4-3-5-8-19/h3-10,13-16,18H,11-12,17H2,1-2H3
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358816
PNG
(US10214544, Example 130)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3cc(OC(F)F)cc(c3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C32H23F5N4O6S/c1-43-19-11-25(22-13-27(47-26(22)12-19)23-14-41-30(38-23)48-31(39-41)44-2)45-15-16-4-3-5-24-21(16)6-7-40(24)28(42)17-8-18(32(35,36)37)10-20(9-17)46-29(33)34/h3-5,8-14,29H,6-7,15H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358820
PNG
(US10214544, Example 135)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)Cc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O5S/c1-35-21-13-24(22-15-26(38-25(22)14-21)23-16-33-28(31-23)39-29(32-33)36-2)37-17-19-9-6-10-20(11-19)30-27(34)12-18-7-4-3-5-8-18/h3-11,13-16H,12,17H2,1-2H3,(H,30,34)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358827
PNG
(US10214544, Example 142)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(F)cc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H20F4N4O5S/c1-39-20-10-23(21-12-25(42-24(21)11-20)22-13-37-27(35-22)43-28(36-37)40-2)41-14-15-4-3-5-19(6-15)34-26(38)16-7-17(29(31,32)33)9-18(30)8-16/h3-13H,14H2,1-2H3,(H,34,38)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358848
PNG
(US10214544, Example 163)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(C)c(F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H23FN4O5S/c1-16-7-8-18(10-22(16)30)27(35)31-19-6-4-5-17(9-19)15-38-24-11-20(36-2)12-25-21(24)13-26(39-25)23-14-34-28(32-23)40-29(33-34)37-3/h4-14H,15H2,1-3H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358175
PNG
(US10214544, Example 3 | tert-Butyl (3-(((6-methoxy...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)OC(C)(C)C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O6S/c1-26(2,3)36-24(31)27-16-8-6-7-15(9-16)14-34-20-10-17(32-4)11-21-18(20)12-22(35-21)19-13-30-23(28-19)37-25(29-30)33-5/h6-13H,14H2,1-5H3,(H,27,31)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358191
PNG
(N-(3-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NS(=O)(=O)c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N4O6S2/c1-34-19-12-23(21-14-25(37-24(21)13-19)22-15-31-26(28-22)38-27(29-31)35-2)36-16-17-7-6-8-18(11-17)30-39(32,33)20-9-4-3-5-10-20/h3-15,30H,16H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358222
PNG
(US10214544, Example 16)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(c4)C#N)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21N5O5S/c1-36-21-11-24(22-13-26(39-25(22)12-21)23-15-34-28(32-23)40-29(33-34)37-2)38-16-18-6-4-8-20(10-18)31-27(35)19-7-3-5-17(9-19)14-30/h3-13,15H,16H2,1-2H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358280
PNG
(US10214544, Example 24)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4I)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21IN4O5S/c1-35-18-11-23(20-13-25(38-24(20)12-18)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-6-5-7-17(10-16)30-26(34)19-8-3-4-9-21(19)29/h3-14H,15H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358409
PNG
(US10214544, Example 27)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O5S/c1-17-7-4-5-10-21(17)27(34)30-19-9-6-8-18(11-19)16-37-24-12-20(35-2)13-25-22(24)14-26(38-25)23-15-33-28(31-23)39-29(32-33)36-3/h4-15H,16H2,1-3H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358410
PNG
(US10214544, Example 28)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21FN4O5S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-5-3-8-19(9-16)30-26(34)17-6-4-7-18(29)10-17/h3-14H,15H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358411
PNG
(US10214544, Example 29)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4OC)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O6S/c1-35-19-12-24(21-14-26(39-25(21)13-19)22-15-33-28(31-22)40-29(32-33)37-3)38-16-17-7-6-8-18(11-17)30-27(34)20-9-4-5-10-23(20)36-2/h4-15H,16H2,1-3H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358473
PNG
(US10214544, Example 31)
Show SMILES CCCc1ccc(cc1)C(=O)Nc1cccc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)c1
Show InChI InChI=1S/C31H28N4O5S/c1-4-6-19-9-11-21(12-10-19)29(36)32-22-8-5-7-20(13-22)18-39-26-14-23(37-2)15-27-24(26)16-28(40-27)25-17-35-30(33-25)41-31(34-35)38-3/h5,7-17H,4,6,18H2,1-3H3,(H,32,36)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358488
PNG
(US10214544, Example 35)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)COc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O6S/c1-35-21-12-24(22-14-26(39-25(22)13-21)23-15-33-28(31-23)40-29(32-33)36-2)38-16-18-7-6-8-19(11-18)30-27(34)17-37-20-9-4-3-5-10-20/h3-15H,16-17H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358542
PNG
(US10214544, Example 48)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccnc(F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H20FN5O5S/c1-35-18-10-21(19-12-23(38-22(19)11-18)20-13-33-26(31-20)39-27(32-33)36-2)37-14-15-4-3-5-17(8-15)30-25(34)16-6-7-29-24(28)9-16/h3-13H,14H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358549
PNG
(US10214544, Example 50)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4sc(C)nc4C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H23N5O5S2/c1-14-24(38-15(2)28-14)25(33)29-17-7-5-6-16(8-17)13-36-21-9-18(34-3)10-22-19(21)11-23(37-22)20-12-32-26(30-20)39-27(31-32)35-4/h5-12H,13H2,1-4H3,(H,29,33)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358758
PNG
(US10214544, Example 63)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(Cl)cc(OC)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H23ClN4O6S/c1-36-20-9-17(8-18(30)10-20)27(35)31-19-6-4-5-16(7-19)15-39-24-11-21(37-2)12-25-22(24)13-26(40-25)23-14-34-28(32-23)41-29(33-34)38-3/h4-14H,15H2,1-3H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358772
PNG
(US10214544, Example 77)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4csc(n4)-c4ccc(F)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H22FN5O5S2/c1-39-21-11-25(22-13-27(42-26(22)12-21)23-14-37-30(35-23)44-31(36-37)40-2)41-15-17-4-3-5-20(10-17)33-28(38)24-16-43-29(34-24)18-6-8-19(32)9-7-18/h3-14,16H,15H2,1-2H3,(H,33,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358776
PNG
(3-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]th...)
Show SMILES CNc1cccc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)c1
Show InChI InChI=1S/C22H20N4O4S/c1-23-14-6-4-5-13(7-14)12-29-18-8-15(27-2)9-19-16(18)10-20(30-19)17-11-26-21(24-17)31-22(25-26)28-3/h4-11,23H,12H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358777
PNG
(N-(3-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O5S/c1-32(27(34)19-9-5-4-6-10-19)20-11-7-8-18(12-20)17-37-24-13-21(35-2)14-25-22(24)15-26(38-25)23-16-33-28(30-23)39-29(31-33)36-3/h4-16H,17H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358781
PNG
(US10214544, Example 87)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C29H23FN4O5S/c1-33(27(35)18-7-9-19(30)10-8-18)20-6-4-5-17(11-20)16-38-24-12-21(36-2)13-25-22(24)14-26(39-25)23-15-34-28(31-23)40-29(32-34)37-3/h4-15H,16H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358785
PNG
(US10214544, Example 91)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)S(=O)(=O)c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C28H24N4O6S2/c1-31(40(33,34)21-10-5-4-6-11-21)19-9-7-8-18(12-19)17-37-24-13-20(35-2)14-25-22(24)15-26(38-25)23-16-32-27(29-23)39-28(30-32)36-3/h4-16H,17H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358801
PNG
((4-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]t...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C30H24N4O5S/c1-36-20-13-25(22-15-27(39-26(22)14-20)23-16-34-29(31-23)40-30(32-34)37-2)38-17-19-9-6-10-24-21(19)11-12-33(24)28(35)18-7-4-3-5-8-18/h3-10,13-16H,11-12,17H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358802
PNG
(US10214544, Example 116)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C30H23FN4O5S/c1-37-20-12-25(22-14-27(40-26(22)13-20)23-15-35-29(32-23)41-30(33-35)38-2)39-16-18-4-3-5-24-21(18)10-11-34(24)28(36)17-6-8-19(31)9-7-17/h3-9,12-15H,10-11,16H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358808
PNG
(US10214544, Example 122)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccccc3C)cc(OC)cc2o1
Show InChI InChI=1S/C31H26N4O5S/c1-18-7-4-5-9-21(18)29(36)34-12-11-22-19(8-6-10-25(22)34)17-39-26-13-20(37-2)14-27-23(26)15-28(40-27)24-16-35-30(32-24)41-31(33-35)38-3/h4-10,13-16H,11-12,17H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358822
PNG
(US10214544, Example 137)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(OC)cc(OC)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H26N4O7S/c1-36-20-9-18(10-21(11-20)37-2)28(35)31-19-7-5-6-17(8-19)16-40-25-12-22(38-3)13-26-23(25)14-27(41-26)24-15-34-29(32-24)42-30(33-34)39-4/h5-15H,16H2,1-4H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358826
PNG
(US10214544, Example 141)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(F)cc4C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H20F4N4O5S/c1-39-18-10-23(20-12-25(42-24(20)11-18)22-13-37-27(35-22)43-28(36-37)40-2)41-14-15-4-3-5-17(8-15)34-26(38)19-7-6-16(30)9-21(19)29(31,32)33/h3-13H,14H2,1-2H3,(H,34,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358831
PNG
(US10214544, Example 146)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)CC4CCCCC4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H30N4O5S/c1-35-21-13-24(22-15-26(38-25(22)14-21)23-16-33-28(31-23)39-29(32-33)36-2)37-17-19-9-6-10-20(11-19)30-27(34)12-18-7-4-3-5-8-18/h6,9-11,13-16,18H,3-5,7-8,12,17H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358836
PNG
(US10214544, Example 151)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(Cl)c4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20ClFN4O5S/c1-36-17-10-22(19-12-24(39-23(19)11-17)21-13-34-27(32-21)40-28(33-34)37-2)38-14-15-5-3-6-16(9-15)31-26(35)18-7-4-8-20(29)25(18)30/h3-13H,14H2,1-2H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358846
PNG
(US10214544, Example 161)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(c(F)c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H20F4N4O5S/c1-39-18-10-23(19-12-25(42-24(19)11-18)22-13-37-27(35-22)43-28(36-37)40-2)41-14-15-4-3-5-17(8-15)34-26(38)16-6-7-20(21(30)9-16)29(31,32)33/h3-13H,14H2,1-2H3,(H,34,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358850
PNG
(US10214544, Example 165)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)C4CCOCC4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H26N4O6S/c1-33-19-11-22(36-15-16-4-3-5-18(10-16)28-25(32)17-6-8-35-9-7-17)20-13-24(37-23(20)12-19)21-14-31-26(29-21)38-27(30-31)34-2/h3-5,10-14,17H,6-9,15H2,1-2H3,(H,28,32)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358160
PNG
(4-Fluoro-N-(3-(((6-methoxy-2-(2-methoxyimidazo[2,1...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(F)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21FN4O5S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-4-3-5-19(10-16)30-26(34)17-6-8-18(29)9-7-17/h3-14H,15H2,1-2H3,(H,30,34)
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358187
PNG
(N-(3-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(OC(F)(F)F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21F3N4O6S/c1-38-20-11-23(21-13-25(41-24(21)12-20)22-14-36-27(34-22)43-28(35-36)39-2)40-15-16-5-3-7-18(9-16)33-26(37)17-6-4-8-19(10-17)42-29(30,31)32/h3-14H,15H2,1-2H3,(H,33,37)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358194
PNG
(US10214544, Example 9)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(ccc4C(F)(F)F)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H20F6N4O5S/c1-42-18-10-23(20-12-25(45-24(20)11-18)22-13-40-27(38-22)46-28(39-40)43-2)44-14-15-4-3-5-17(8-15)37-26(41)19-9-16(29(31,32)33)6-7-21(19)30(34,35)36/h3-13H,14H2,1-2H3,(H,37,41)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358221
PNG
(US10214544, Example 15)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc5ccccc45)c3)cc(OC)cc2o1
Show InChI InChI=1S/C32H24N4O5S/c1-38-22-14-27(25-16-29(41-28(25)15-22)26-17-36-31(34-26)42-32(35-36)39-2)40-18-19-7-5-10-21(13-19)33-30(37)24-12-6-9-20-8-3-4-11-23(20)24/h3-17H,18H2,1-2H3,(H,33,37)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358465
PNG
(US10214544, Example 30)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(F)c(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H20F4N4O5S/c1-39-18-10-23(19-12-25(42-24(19)11-18)22-13-37-27(35-22)43-28(36-37)40-2)41-14-15-4-3-5-17(8-15)34-26(38)16-6-7-21(30)20(9-16)29(31,32)33/h3-13H,14H2,1-2H3,(H,34,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358491
PNG
(US10214544, Example 36)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(cc4)C#N)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21N5O5S/c1-36-21-11-24(22-13-26(39-25(22)12-21)23-15-34-28(32-23)40-29(33-34)37-2)38-16-18-4-3-5-20(10-18)31-27(35)19-8-6-17(14-30)7-9-19/h3-13,15H,16H2,1-2H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358503
PNG
(US10214544, Example 39)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(I)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21IN4O5S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-4-3-5-19(10-16)30-26(34)17-6-8-18(29)9-7-17/h3-14H,15H2,1-2H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358521
PNG
(US10214544, Example 155 | US10214544, Example 44)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccno4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C25H19N5O6S/c1-32-16-9-20(34-13-14-4-3-5-15(8-14)27-23(31)19-6-7-26-36-19)17-11-22(35-21(17)10-16)18-12-30-24(28-18)37-25(29-30)33-2/h3-12H,13H2,1-2H3,(H,27,31)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358562
PNG
(US10214544, Example 56)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccnc(O)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21N5O6S/c1-35-18-10-21(19-12-23(38-22(19)11-18)20-13-32-26(30-20)39-27(31-32)36-2)37-14-15-4-3-5-17(8-15)29-25(34)16-6-7-28-24(33)9-16/h3-13H,14H2,1-2H3,(H,28,33)(H,29,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358565
PNG
(US10214544, Example 57)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cncnc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H20N6O5S/c1-34-18-7-21(36-13-15-4-3-5-17(6-15)29-24(33)16-10-27-14-28-11-16)19-9-23(37-22(19)8-18)20-12-32-25(30-20)38-26(31-32)35-2/h3-12,14H,13H2,1-2H3,(H,29,33)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358762
PNG
(US10214544, Example 67)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(Cl)cc(OCc5ccccc5)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C35H27ClN4O6S/c1-42-26-15-30(28-17-32(46-31(28)16-26)29-18-40-34(38-29)47-35(39-40)43-2)45-20-22-9-6-10-25(11-22)37-33(41)23-12-24(36)14-27(13-23)44-19-21-7-4-3-5-8-21/h3-18H,19-20H2,1-2H3,(H,37,41)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358771
PNG
(US10214544, Example 76)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(F)cc(OC(F)(F)F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H20F4N4O6S/c1-39-19-10-23(21-12-25(42-24(21)11-19)22-13-37-27(35-22)44-28(36-37)40-2)41-14-15-4-3-5-18(6-15)34-26(38)16-7-17(30)9-20(8-16)43-29(31,32)33/h3-13H,14H2,1-2H3,(H,34,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358773
PNG
(US10214544, Example 78)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(OC)cc(OC(F)F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H24F2N4O7S/c1-38-19-8-17(9-21(10-19)42-28(31)32)27(37)33-18-6-4-5-16(7-18)15-41-24-11-20(39-2)12-25-22(24)13-26(43-25)23-14-36-29(34-23)44-30(35-36)40-3/h4-14,28H,15H2,1-3H3,(H,33,37)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358806
PNG
(US10214544, Example 120)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccccc3F)cc(OC)cc2o1
Show InChI InChI=1S/C30H23FN4O5S/c1-37-18-12-25(21-14-27(40-26(21)13-18)23-15-35-29(32-23)41-30(33-35)38-2)39-16-17-6-5-9-24-19(17)10-11-34(24)28(36)20-7-3-4-8-22(20)31/h3-9,12-15H,10-11,16H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358810
PNG
(US10214544, Example 124)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccccc3OC)cc(OC)cc2o1
Show InChI InChI=1S/C31H26N4O6S/c1-37-19-13-26(22-15-28(41-27(22)14-19)23-16-35-30(32-23)42-31(33-35)39-3)40-17-18-7-6-9-24-20(18)11-12-34(24)29(36)21-8-4-5-10-25(21)38-2/h4-10,13-16H,11-12,17H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358812
PNG
(US10214544, Example 126)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3cncnc3)cc(OC)cc2o1
Show InChI InChI=1S/C28H22N6O5S/c1-36-18-8-23(20-10-25(39-24(20)9-18)21-13-34-27(31-21)40-28(32-34)37-2)38-14-16-4-3-5-22-19(16)6-7-33(22)26(35)17-11-29-15-30-12-17/h3-5,8-13,15H,6-7,14H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358815
PNG
(US10214544, Example 129)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3sc(C)nc3C)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N5O5S2/c1-15-26(40-16(2)30-15)27(35)33-9-8-19-17(6-5-7-22(19)33)14-38-23-10-18(36-3)11-24-20(23)12-25(39-24)21-13-34-28(31-21)41-29(32-34)37-4/h5-7,10-13H,8-9,14H2,1-4H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358819
PNG
(US10214544, Example 134)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccco4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H20N4O6S/c1-32-17-10-21(35-14-15-5-3-6-16(9-15)27-24(31)20-7-4-8-34-20)18-12-23(36-22(18)11-17)19-13-30-25(28-19)37-26(29-30)33-2/h3-13H,14H2,1-2H3,(H,27,31)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358821
PNG
(US10214544, Example 136)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)C(C)C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C25H24N4O5S/c1-14(2)23(30)26-16-7-5-6-15(8-16)13-33-20-9-17(31-3)10-21-18(20)11-22(34-21)19-12-29-24(27-19)35-25(28-29)32-4/h5-12,14H,13H2,1-4H3,(H,26,30)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358824
PNG
(US10214544, Example 139)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccn4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21N5O5S/c1-34-18-11-22(36-15-16-6-5-7-17(10-16)29-25(33)20-8-3-4-9-28-20)19-13-24(37-23(19)12-18)21-14-32-26(30-21)38-27(31-32)35-2/h3-14H,15H2,1-2H3,(H,29,33)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358830
PNG
(US10214544, Example 145)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)C4CCCC4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H26N4O5S/c1-33-19-11-22(35-15-16-6-5-9-18(10-16)28-25(32)17-7-3-4-8-17)20-13-24(36-23(20)12-19)21-14-31-26(29-21)37-27(30-31)34-2/h5-6,9-14,17H,3-4,7-8,15H2,1-2H3,(H,28,32)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358843
PNG
(US10214544, Example 158)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(c4)-c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C34H26N4O5S/c1-40-26-16-29(27-18-31(43-30(27)17-26)28-19-38-33(36-28)44-34(37-38)41-2)42-20-21-8-6-13-25(14-21)35-32(39)24-12-7-11-23(15-24)22-9-4-3-5-10-22/h3-19H,20H2,1-2H3,(H,35,39)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358193
PNG
(US10214544, Example 8)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4OC(C)=O)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H24N4O7S/c1-17(35)40-24-10-5-4-9-21(24)28(36)31-19-8-6-7-18(11-19)16-39-25-12-20(37-2)13-26-22(25)14-27(41-26)23-15-34-29(32-23)42-30(33-34)38-3/h4-15H,16H2,1-3H3,(H,31,36)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358259
PNG
(US10214544, Example 20)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(C)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N4O5S/c1-17-6-4-8-19(10-17)27(34)30-20-9-5-7-18(11-20)16-37-24-12-21(35-2)13-25-22(24)14-26(38-25)23-15-33-28(31-23)39-29(32-33)36-3/h4-15H,16H2,1-3H3,(H,30,34)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358522
PNG
(US10214544, Example 45)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4c(C)noc4C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H23N5O6S/c1-14-24(15(2)38-31-14)25(33)28-17-7-5-6-16(8-17)13-36-21-9-18(34-3)10-22-19(21)11-23(37-22)20-12-32-26(29-20)39-27(30-32)35-4/h5-12H,13H2,1-4H3,(H,28,33)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358567
PNG
(US10214544, Example 59)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4c(C)noc4-c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C32H25N5O6S/c1-18-28(29(43-36-18)20-9-5-4-6-10-20)30(38)33-21-11-7-8-19(12-21)17-41-25-13-22(39-2)14-26-23(25)15-27(42-26)24-16-37-31(34-24)44-32(35-37)40-3/h4-16H,17H2,1-3H3,(H,33,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358768
PNG
(US10214544, Example 73)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(C)nc4O)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N5O6S/c1-15-7-8-19(25(34)29-15)26(35)30-17-6-4-5-16(9-17)14-38-22-10-18(36-2)11-23-20(22)12-24(39-23)21-13-33-27(31-21)40-28(32-33)37-3/h4-13H,14H2,1-3H3,(H,29,34)(H,30,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358770
PNG
(US10214544, Example 75)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(F)ccc4C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H23FN4O5S/c1-16-7-8-18(30)10-21(16)27(35)31-19-6-4-5-17(9-19)15-38-24-11-20(36-2)12-25-22(24)13-26(39-25)23-14-34-28(32-23)40-29(33-34)37-3/h4-14H,15H2,1-3H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358794
PNG
(US10214544, Example 105)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5ccc(C)cc5)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H26N4O5S/c1-18-4-7-21(8-5-18)29(36)34-11-10-20-9-6-19(12-25(20)34)17-39-26-13-22(37-2)14-27-23(26)15-28(40-27)24-16-35-30(32-24)41-31(33-35)38-3/h4-9,12-16H,10-11,17H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358809
PNG
(US10214544, Example 123)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccc(C)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C31H26N4O5S/c1-18-7-9-19(10-8-18)29(36)34-12-11-22-20(5-4-6-25(22)34)17-39-26-13-21(37-2)14-27-23(26)15-28(40-27)24-16-35-30(32-24)41-31(33-35)38-3/h4-10,13-16H,11-12,17H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358818
PNG
(US10214544, Example 133)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cnccn4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H20N6O5S/c1-34-17-9-21(36-14-15-4-3-5-16(8-15)29-24(33)19-12-27-6-7-28-19)18-11-23(37-22(18)10-17)20-13-32-25(30-20)38-26(31-32)35-2/h3-13H,14H2,1-2H3,(H,29,33)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358834
PNG
(US10214544, Example 149)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21F3N4O5S/c1-38-20-11-23(21-13-25(41-24(21)12-20)22-14-36-27(34-22)42-28(35-36)39-2)40-15-16-5-3-8-19(9-16)33-26(37)17-6-4-7-18(10-17)29(30,31)32/h3-14H,15H2,1-2H3,(H,33,37)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358837
PNG
(US10214544, Example 152)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(F)cc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F2N4O5S/c1-36-18-10-23(20-12-25(39-24(20)11-18)22-13-34-27(32-22)40-28(33-34)37-2)38-14-15-4-3-5-17(8-15)31-26(35)19-7-6-16(29)9-21(19)30/h3-13H,14H2,1-2H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358177
PNG
(3-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]th...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(N)c3)cc(OC)cc2o1
Show InChI InChI=1S/C21H18N4O4S/c1-26-14-7-17(28-11-12-4-3-5-13(22)6-12)15-9-19(29-18(15)8-14)16-10-25-20(23-16)30-21(24-25)27-2/h3-10H,11,22H2,1-2H3
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358233
PNG
(US10214544, Example 17)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)COCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H26N4O6S/c1-36-22-12-25(23-14-27(40-26(23)13-22)24-15-34-29(32-24)41-30(33-34)37-2)39-17-20-9-6-10-21(11-20)31-28(35)18-38-16-19-7-4-3-5-8-19/h3-15H,16-18H2,1-2H3,(H,31,35)
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358255
PNG
(US10214544, Example 19)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(Cl)cc(Cl)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20Cl2N4O5S/c1-36-20-10-23(21-12-25(39-24(21)11-20)22-13-34-27(32-22)40-28(33-34)37-2)38-14-15-4-3-5-19(6-15)31-26(35)16-7-17(29)9-18(30)8-16/h3-13H,14H2,1-2H3,(H,31,35)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358504
PNG
(US10214544, Example 40)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)C(C)(C)Oc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H28N4O6S/c1-31(2,41-21-11-6-5-7-12-21)28(36)32-20-10-8-9-19(13-20)18-39-25-14-22(37-3)15-26-23(25)16-27(40-26)24-17-35-29(33-24)42-30(34-35)38-4/h5-17H,18H2,1-4H3,(H,32,36)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358541
PNG
(US10214544, Example 47)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)Cc4cc(C)no4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H23N5O6S/c1-15-7-19(38-31-15)11-25(33)28-17-6-4-5-16(8-17)14-36-22-9-18(34-2)10-23-20(22)12-24(37-23)21-13-32-26(29-21)39-27(30-32)35-3/h4-10,12-13H,11,14H2,1-3H3,(H,28,33)
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358551
PNG
(US10214544, Example 51)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(Oc5ccccc5)nc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C33H25N5O6S/c1-40-24-14-27(25-16-29(44-28(25)15-24)26-18-38-32(36-26)45-33(37-38)41-2)42-19-20-7-6-8-22(13-20)35-31(39)21-11-12-30(34-17-21)43-23-9-4-3-5-10-23/h3-18H,19H2,1-2H3,(H,35,39)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358757
PNG
(US10214544, Example 62)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(OCc5ccccc5)cc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C36H27F3N4O6S/c1-45-26-15-30(28-17-32(49-31(28)16-26)29-18-43-34(41-29)50-35(42-43)46-2)48-20-22-9-6-10-25(11-22)40-33(44)23-12-24(36(37,38)39)14-27(13-23)47-19-21-7-4-3-5-8-21/h3-18H,19-20H2,1-2H3,(H,40,44)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358766
PNG
(US10214544, Example 71)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(C)cc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H23F3N4O5S/c1-16-7-18(10-19(8-16)30(31,32)33)27(38)34-20-6-4-5-17(9-20)15-41-24-11-21(39-2)12-25-22(24)13-26(42-25)23-14-37-28(35-23)43-29(36-37)40-3/h4-14H,15H2,1-3H3,(H,34,38)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358767
PNG
(US10214544, Example 72)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4csc(n4)-c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H23N5O5S2/c1-38-21-12-25(22-14-27(41-26(22)13-21)23-15-36-30(34-23)43-31(35-36)39-2)40-16-18-7-6-10-20(11-18)32-28(37)24-17-42-29(33-24)19-8-4-3-5-9-19/h3-15,17H,16H2,1-2H3,(H,32,37)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358778
PNG
(US10214544, Example 84)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3ccccc3C)cc(OC)cc2o1
Show InChI InChI=1S/C30H26N4O5S/c1-18-8-5-6-11-22(18)28(35)33(2)20-10-7-9-19(12-20)17-38-25-13-21(36-3)14-26-23(25)15-27(39-26)24-16-34-29(31-24)40-30(32-34)37-4/h5-16H,17H2,1-4H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358790
PNG
(US10214544, Example 101)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5ccccc5C)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H26N4O5S/c1-18-6-4-5-7-22(18)29(36)34-11-10-20-9-8-19(12-25(20)34)17-39-26-13-21(37-2)14-27-23(26)15-28(40-27)24-16-35-30(32-24)41-31(33-35)38-3/h4-9,12-16H,10-11,17H2,1-3H3
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US Patent
n/an/an/an/a 3.10n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358793
PNG
(US10214544, Example 104)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5ccccc5F)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H23FN4O5S/c1-37-19-12-25(21-14-27(40-26(21)13-19)23-15-35-29(32-23)41-30(33-35)38-2)39-16-17-7-8-18-9-10-34(24(18)11-17)28(36)20-5-3-4-6-22(20)31/h3-8,11-15H,9-10,16H2,1-2H3
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n/an/an/an/a 2.20n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358804
PNG
(US10214544, Example 118)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3csc(n3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F3N5O5S2/c1-38-15-8-21(17-10-23(41-22(17)9-15)18-11-36-26(33-18)43-27(34-36)39-2)40-12-14-4-3-5-20-16(14)6-7-35(20)24(37)19-13-42-25(32-19)28(29,30)31/h3-5,8-11,13H,6-7,12H2,1-2H3
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358811
PNG
(US10214544, Example 125)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3cc(C)cc(c3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C32H25F3N4O5S/c1-17-9-19(11-20(10-17)32(33,34)35)29(40)38-8-7-22-18(5-4-6-25(22)38)16-43-26-12-21(41-2)13-27-23(26)14-28(44-27)24-15-39-30(36-24)45-31(37-39)42-3/h4-6,9-15H,7-8,16H2,1-3H3
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358829
PNG
(US10214544, Example 144)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(c4)N(C)C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H27N5O5S/c1-34(2)21-10-6-8-19(12-21)28(36)31-20-9-5-7-18(11-20)17-39-25-13-22(37-3)14-26-23(25)15-27(40-26)24-16-35-29(32-24)41-30(33-35)38-4/h5-16H,17H2,1-4H3,(H,31,36)
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Universite De Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358842
PNG
(US10214544, Example 157)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(OC)c(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H23F3N4O6S/c1-39-19-11-24(20-13-26(43-25(20)12-19)22-14-37-28(35-22)44-29(36-37)41-3)42-15-16-5-4-6-18(9-16)34-27(38)17-7-8-23(40-2)21(10-17)30(31,32)33/h4-14H,15H2,1-3H3,(H,34,38)
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358183
PNG
(4-Chloro-N-(3-(((6-methoxy-2-(2-methoxyimidazo[2,1...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(Cl)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21ClN4O5S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-4-3-5-19(10-16)30-26(34)17-6-8-18(29)9-7-17/h3-14H,15H2,1-2H3,(H,30,34)
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358198
PNG
(US10214544, Example 11)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccc(Cl)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21ClN4O5S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-5-3-8-19(9-16)30-26(34)17-6-4-7-18(29)10-17/h3-14H,15H2,1-2H3,(H,30,34)
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358219
PNG
(US10214544, Example 13)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21F3N4O5S/c1-38-18-11-23(20-13-25(41-24(20)12-18)22-14-36-27(34-22)42-28(35-36)39-2)40-15-16-6-5-7-17(10-16)33-26(37)19-8-3-4-9-21(19)29(30,31)32/h3-14H,15H2,1-2H3,(H,33,37)
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Universite De Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358265
PNG
(US10214544, Example 22)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc5OCOc5c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H22N4O7S/c1-35-19-10-23(20-12-25(40-24(20)11-19)21-13-33-28(31-21)41-29(32-33)36-2)37-14-16-4-3-5-18(8-16)30-27(34)17-6-7-22-26(9-17)39-15-38-22/h3-13H,14-15H2,1-2H3,(H,30,34)
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358408
PNG
(US10214544, Example 26)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccccc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21FN4O5S/c1-35-18-11-23(20-13-25(38-24(20)12-18)22-14-33-27(31-22)39-28(32-33)36-2)37-15-16-6-5-7-17(10-16)30-26(34)19-8-3-4-9-21(19)29/h3-14H,15H2,1-2H3,(H,30,34)
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358561
PNG
(US10214544, Example 55)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(Cl)nc(Cl)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H19Cl2N5O5S/c1-36-17-9-20(18-11-22(39-21(18)10-17)19-12-34-26(31-19)40-27(33-34)37-2)38-13-14-4-3-5-16(6-14)30-25(35)15-7-23(28)32-24(29)8-15/h3-12H,13H2,1-2H3,(H,30,35)
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358566
PNG
(US10214544, Example 58)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccnc4Cl)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H20ClN5O5S/c1-35-17-10-21(19-12-23(38-22(19)11-17)20-13-33-26(31-20)39-27(32-33)36-2)37-14-15-5-3-6-16(9-15)30-25(34)18-7-4-8-29-24(18)28/h3-13H,14H2,1-2H3,(H,30,34)
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358582
PNG
(US10214544, Example 61)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccnc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H20FN5O5S/c1-35-17-10-21(19-12-23(38-22(19)11-17)20-13-33-26(31-20)39-27(32-33)36-2)37-14-15-5-3-6-16(9-15)30-25(34)18-7-4-8-29-24(18)28/h3-13H,14H2,1-2H3,(H,30,34)
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358779
PNG
(US10214544, Example 85)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3cccc(F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H23FN4O5S/c1-33(27(35)18-7-5-8-19(30)11-18)20-9-4-6-17(10-20)16-38-24-12-21(36-2)13-25-22(24)14-26(39-25)23-15-34-28(31-23)40-29(32-34)37-3/h4-15H,16H2,1-3H3
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358782
PNG
(US10214544, Example 88)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3ccccc3F)cc(OC)cc2o1
Show InChI InChI=1S/C29H23FN4O5S/c1-33(27(35)20-9-4-5-10-22(20)30)18-8-6-7-17(11-18)16-38-24-12-19(36-2)13-25-21(24)14-26(39-25)23-15-34-28(31-23)40-29(32-34)37-3/h4-15H,16H2,1-3H3
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Universite De Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358786
PNG
(US10214544, Example 92)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3cncnc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N6O5S/c1-32(25(34)17-11-28-15-29-12-17)18-6-4-5-16(7-18)14-37-22-8-19(35-2)9-23-20(22)10-24(38-23)21-13-33-26(30-21)39-27(31-33)36-3/h4-13,15H,14H2,1-3H3
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358792
PNG
(US10214544, Example 103)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5ccccc5OC)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H26N4O6S/c1-37-20-13-26(22-15-28(41-27(22)14-20)23-16-35-30(32-23)42-31(33-35)39-3)40-17-18-8-9-19-10-11-34(24(19)12-18)29(36)21-6-4-5-7-25(21)38-2/h4-9,12-16H,10-11,17H2,1-3H3
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Universite De Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358795
PNG
(US10214544, Example 106)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5ccc(OC)nc5)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H25N5O6S/c1-37-20-11-24(21-13-26(41-25(21)12-20)22-15-35-29(32-22)42-30(33-35)39-3)40-16-17-4-5-18-8-9-34(23(18)10-17)28(36)19-6-7-27(38-2)31-14-19/h4-7,10-15H,8-9,16H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358798
PNG
(US10214544, Example 111)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5cc(C)cc(c5)C(F)(F)F)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C32H25F3N4O5S/c1-17-8-20(11-21(9-17)32(33,34)35)29(40)38-7-6-19-5-4-18(10-25(19)38)16-43-26-12-22(41-2)13-27-23(26)14-28(44-27)24-15-39-30(36-24)45-31(37-39)42-3/h4-5,8-15H,6-7,16H2,1-3H3
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Universite De Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358799
PNG
(US10214544, Example 112)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc4CCN(C(=O)c5csc(n5)-c5ccccc5)c4c3)cc(OC)cc2o1
Show InChI InChI=1S/C33H25N5O5S2/c1-40-22-13-27(23-15-29(43-28(23)14-22)24-16-38-32(35-24)45-33(36-38)41-2)42-17-19-8-9-20-10-11-37(26(20)12-19)31(39)25-18-44-30(34-25)21-6-4-3-5-7-21/h3-9,12-16,18H,10-11,17H2,1-2H3
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358814
PNG
(US10214544, Example 128)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc4N(CCc34)C(=O)c3ccnnc3)cc(OC)cc2o1
Show InChI InChI=1S/C28H22N6O5S/c1-36-18-10-23(20-12-25(39-24(20)11-18)21-14-34-27(31-21)40-28(32-34)37-2)38-15-17-4-3-5-22-19(17)7-9-33(22)26(35)16-6-8-29-30-13-16/h3-6,8,10-14H,7,9,15H2,1-2H3
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Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358817
PNG
(US10214544, Example 132)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccn4C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H23N5O5S/c1-31-9-5-8-21(31)25(33)28-17-7-4-6-16(10-17)15-36-22-11-18(34-2)12-23-19(22)13-24(37-23)20-14-32-26(29-20)38-27(30-32)35-3/h4-14H,15H2,1-3H3,(H,28,33)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.80n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358832
PNG
(US10214544, Example 147)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4c(F)cccc4C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H20F4N4O5S/c1-39-17-10-22(18-12-24(42-23(18)11-17)21-13-37-27(35-21)43-28(36-37)40-2)41-14-15-5-3-6-16(9-15)34-26(38)25-19(29(31,32)33)7-4-8-20(25)30/h3-13H,14H2,1-2H3,(H,34,38)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.60n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358833
PNG
(US10214544, Example 148)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cccnc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21N5O5S/c1-34-19-10-22(36-15-16-5-3-7-18(9-16)29-25(33)17-6-4-8-28-13-17)20-12-24(37-23(20)11-19)21-14-32-26(30-21)38-27(31-32)35-2/h3-14H,15H2,1-2H3,(H,29,33)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6.80n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358844
PNG
(US10214544, Example 159)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4cc(F)cc(F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F2N4O5S/c1-36-20-10-23(21-12-25(39-24(21)11-20)22-13-34-27(32-22)40-28(33-34)37-2)38-14-15-4-3-5-19(6-15)31-26(35)16-7-17(29)9-18(30)8-16/h3-13H,14H2,1-2H3,(H,31,35)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.60n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))		BDBM358851
PNG
(US10214544, Example 166)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(NC(=O)c4ccc(F)c(F)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F2N4O5S/c1-36-18-10-23(19-12-25(39-24(19)11-18)22-13-34-27(32-22)40-28(33-34)37-2)38-14-15-4-3-5-17(8-15)31-26(35)16-6-7-20(29)21(30)9-16/h3-13H,14H2,1-2H3,(H,31,35)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.30n/an/an/an/a



Universite De Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10214544 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%