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Patent code US10220048

Compile Data Set for Download or QSAR
Found 100 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359101
PNG
(US10220048, Compound AA11)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)C1CC1
Show InChI InChI=1S/C25H28N4O6S2/c1-35-25(31)28-20(13-16-5-3-2-4-6-16)23(30)26-21(24-27-22(15-36-24)18-9-10-18)14-17-7-11-19(12-8-17)29-37(32,33)34/h2-8,11-12,15,18,20-21,29H,9-10,13-14H2,1H3,(H,26,30)(H,28,31)(H,32,33,34)/t20-,21-/m0/s1
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0100n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359121
PNG
(US10220048, Compound AA31)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(CS(=O)(=O)c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C29H29ClN4O8S3/c1-42-29(36)33-25(16-19-5-3-2-4-6-19)28(35)32-24(15-20-7-11-22(12-8-20)34-45(39,40)41)26-17-43-27(31-26)18-44(37,38)23-13-9-21(30)10-14-23/h2-14,17,24-25,34H,15-16,18H2,1H3,(H,32,35)(H,33,36)(H,39,40,41)/t24-,25-/m0/s1
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UniChem
US Patent
n/an/a 0.0800n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359106
PNG
(US10220048, Compound AA16)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(CCC(F)(F)F)cs1
Show InChI InChI=1S/C25H27F3N4O6S2/c1-38-24(34)31-20(13-16-5-3-2-4-6-16)22(33)30-21(23-29-19(15-39-23)11-12-25(26,27)28)14-17-7-9-18(10-8-17)32-40(35,36)37/h2-10,15,20-21,32H,11-14H2,1H3,(H,30,33)(H,31,34)(H,35,36,37)/t20-,21-/m0/s1
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0800n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359113
PNG
(US10220048, Compound AA23)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccsc1
Show InChI InChI=1S/C26H26N4O6S3/c1-36-26(32)29-21(13-17-5-3-2-4-6-17)24(31)27-22(25-28-23(16-38-25)19-11-12-37-15-19)14-18-7-9-20(10-8-18)30-39(33,34)35/h2-12,15-16,21-22,30H,13-14H2,1H3,(H,27,31)(H,29,32)(H,33,34,35)/t21-,22-/m0/s1
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UniChem
US Patent
n/an/a 0.0900n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359099
PNG
(US10220048, Compound AA9)
Show SMILES CCCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC
Show InChI InChI=1S/C25H30N4O6S2/c1-3-7-20-16-36-24(26-20)22(15-18-10-12-19(13-11-18)29-37(32,33)34)27-23(30)21(28-25(31)35-2)14-17-8-5-4-6-9-17/h4-6,8-13,16,21-22,29H,3,7,14-15H2,1-2H3,(H,27,30)(H,28,31)(H,32,33,34)/t21-,22-/m0/s1
PDB

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UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359104
PNG
(US10220048, Compound AA14)
Show SMILES CCc1nc(sc1C)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC
Show InChI InChI=1S/C25H30N4O6S2/c1-4-20-16(2)36-24(27-20)22(15-18-10-12-19(13-11-18)29-37(32,33)34)26-23(30)21(28-25(31)35-3)14-17-8-6-5-7-9-17/h5-13,21-22,29H,4,14-15H2,1-3H3,(H,26,30)(H,28,31)(H,32,33,34)/t21-,22-/m0/s1
PDB

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UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359118
PNG
(US10220048, Compound AA28)
Show SMILES CCc1nc(cs1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC
Show InChI InChI=1S/C24H28N4O6S2/c1-3-22-25-21(15-35-22)19(13-17-9-11-18(12-10-17)28-36(31,32)33)26-23(29)20(27-24(30)34-2)14-16-7-5-4-6-8-16/h4-12,15,19-20,28H,3,13-14H2,1-2H3,(H,26,29)(H,27,30)(H,31,32,33)/t19-,20-/m0/s1
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UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359117
PNG
(US10220048, Compound AA27)
Show SMILES CCOC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(CC)cs1
Show InChI InChI=1S/C25H30N4O6S2/c1-3-19-16-36-24(26-19)22(15-18-10-12-20(13-11-18)29-37(32,33)34)27-23(30)21(28-25(31)35-4-2)14-17-8-6-5-7-9-17/h5-13,16,21-22,29H,3-4,14-15H2,1-2H3,(H,27,30)(H,28,31)(H,32,33,34)/t21-,22-/m0/s1
PDB

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UniChem
US Patent
n/an/a 0.140n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359091
PNG
(US10220048, Compound AA1 | US10220048, Compound AA...)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C21H23N3O4S2/c1-2-17-14-29-21(22-17)19(23-20(25)13-15-6-4-3-5-7-15)12-16-8-10-18(11-9-16)24-30(26,27)28/h3-11,14,19,24H,2,12-13H2,1H3,(H,23,25)(H,26,27,28)/t19-/m0/s1
PDB

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US Patent
n/an/a 0.157n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359096
PNG
(US10220048, Compound AA6)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC
Show InChI InChI=1S/C24H28N4O6S2/c1-3-18-15-35-23(25-18)21(14-17-9-11-19(12-10-17)28-36(31,32)33)26-22(29)20(27-24(30)34-2)13-16-7-5-4-6-8-16/h4-12,15,20-21,28H,3,13-14H2,1-2H3,(H,26,29)(H,27,30)(H,31,32,33)/t20-,21-/m0/s1
PDB

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UniChem
US Patent
n/an/a 0.162n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359178
PNG
(US10220048, Compound AA88)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)CCc1cccc(Cl)c1
Show InChI InChI=1S/C22H24ClN3O4S2/c1-2-18-14-31-22(24-18)20(13-16-6-9-19(10-7-16)26-32(28,29)30)25-21(27)11-8-15-4-3-5-17(23)12-15/h3-7,9-10,12,14,20,26H,2,8,11,13H2,1H3,(H,25,27)(H,28,29,30)/t20-/m0/s1
PDB

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US Patent
n/an/a 0.200n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359120
PNG
(US10220048, Compound AA30)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)C1CC1
Show InChI InChI=1S/C25H28N4O6S2/c1-35-25(31)28-21(14-16-5-3-2-4-6-16)23(30)26-20(22-15-36-24(27-22)18-9-10-18)13-17-7-11-19(12-8-17)29-37(32,33)34/h2-8,11-12,15,18,20-21,29H,9-10,13-14H2,1H3,(H,26,30)(H,28,31)(H,32,33,34)/t20-,21-/m0/s1
PDB

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UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359187
PNG
(US10220048, Compound AA97)
Show SMILES CCCc1nnc(N[C@@H](Cc2ccc(NS(O)(=O)=O)cc2)c2csc(n2)-c2cccs2)s1
Show InChI InChI=1S/C20H21N5O3S4/c1-2-4-18-23-24-20(31-18)22-15(16-12-30-19(21-16)17-5-3-10-29-17)11-13-6-8-14(9-7-13)25-32(26,27)28/h3,5-10,12,15,25H,2,4,11H2,1H3,(H,22,24)(H,26,27,28)/t15-/m0/s1
PDB

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UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359108
PNG
(US10220048, Compound AA18)
Show SMILES CCOC(=O)c1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC
Show InChI InChI=1S/C25H28N4O8S2/c1-3-37-24(31)21-15-38-23(27-21)20(14-17-9-11-18(12-10-17)29-39(33,34)35)26-22(30)19(28-25(32)36-2)13-16-7-5-4-6-8-16/h4-12,15,19-20,29H,3,13-14H2,1-2H3,(H,26,30)(H,28,32)(H,33,34,35)/t19-,20-/m0/s1
PDB

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UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359100
PNG
(US10220048, Compound AA10)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)C(C)(C)C
Show InChI InChI=1S/C26H32N4O6S2/c1-26(2,3)22-16-37-24(29-22)21(15-18-10-12-19(13-11-18)30-38(33,34)35)27-23(31)20(28-25(32)36-4)14-17-8-6-5-7-9-17/h5-13,16,20-21,30H,14-15H2,1-4H3,(H,27,31)(H,28,32)(H,33,34,35)/t20-,21-/m0/s1
PDB

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UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359131
PNG
(US10220048, Compound AA41)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccsc1
Show InChI InChI=1S/C26H26N4O5S3/c1-17(31)27-22(13-18-5-3-2-4-6-18)25(32)28-23(26-29-24(16-37-26)20-11-12-36-15-20)14-19-7-9-21(10-8-19)30-38(33,34)35/h2-12,15-16,22-23,30H,13-14H2,1H3,(H,27,31)(H,28,32)(H,33,34,35)/t22-,23-/m0/s1
PDB

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UniChem
US Patent
n/an/a 0.240n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359130
PNG
(US10220048, Compound AA40)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)C(C)(C)C
Show InChI InChI=1S/C26H32N4O5S2/c1-17(31)27-21(14-18-8-6-5-7-9-18)24(32)28-22(25-29-23(16-36-25)26(2,3)4)15-19-10-12-20(13-11-19)30-37(33,34)35/h5-13,16,21-22,30H,14-15H2,1-4H3,(H,27,31)(H,28,32)(H,33,34,35)/t21-,22-/m0/s1
PDB

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PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359105
PNG
(US10220048, Compound AA15)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(CC(F)(F)F)cs1
Show InChI InChI=1S/C24H25F3N4O6S2/c1-37-23(33)30-19(11-15-5-3-2-4-6-15)21(32)29-20(22-28-18(14-38-22)13-24(25,26)27)12-16-7-9-17(10-8-16)31-39(34,35)36/h2-10,14,19-20,31H,11-13H2,1H3,(H,29,32)(H,30,33)(H,34,35,36)/t19-,20-/m0/s1
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359167
PNG
(US10220048, Compound AA77)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)Cc1cccc(F)c1
Show InChI InChI=1S/C21H22FN3O4S2/c1-2-17-13-30-21(23-17)19(24-20(26)12-15-4-3-5-16(22)10-15)11-14-6-8-18(9-7-14)25-31(27,28)29/h3-10,13,19,25H,2,11-12H2,1H3,(H,24,26)(H,27,28,29)/t19-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359137
PNG
(US10220048, Compound AA47)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)OC
Show InChI InChI=1S/C21H30N4O6S2/c1-5-15-12-32-20(22-15)18(11-14-6-8-16(9-7-14)25-33(28,29)30)23-19(26)17(10-13(2)3)24-21(27)31-4/h6-9,12-13,17-18,25H,5,10-11H2,1-4H3,(H,23,26)(H,24,27)(H,28,29,30)/t17-,18-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359109
PNG
(US10220048, Compound AA19)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1ncc(s1)-c1ccccc1
Show InChI InChI=1S/C28H28N4O6S2/c1-38-28(34)31-23(16-19-8-4-2-5-9-19)26(33)30-24(17-20-12-14-22(15-13-20)32-40(35,36)37)27-29-18-25(39-27)21-10-6-3-7-11-21/h2-15,18,23-24,32H,16-17H2,1H3,(H,30,33)(H,31,34)(H,35,36,37)/t23-,24-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359138
PNG
(US10220048, Compound AA48)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(=O)OC
Show InChI InChI=1S/C26H30N4O7S2/c1-3-19-16-38-26(27-19)22(14-18-9-11-20(12-10-18)30-39(34,35)36)29-25(33)21(13-17-7-5-4-6-8-17)28-23(31)15-24(32)37-2/h4-12,16,21-22,30H,3,13-15H2,1-2H3,(H,28,31)(H,29,33)(H,34,35,36)/t21-,22-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359127
PNG
(US10220048, Compound AA37)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)-c1ccco1
Show InChI InChI=1S/C26H26N4O7S2/c1-36-26(32)29-21(15-17-6-3-2-4-7-17)24(31)27-20(22-16-38-25(28-22)23-8-5-13-37-23)14-18-9-11-19(12-10-18)30-39(33,34)35/h2-13,16,20-21,30H,14-15H2,1H3,(H,27,31)(H,29,32)(H,33,34,35)/t20-,21-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359115
PNG
(US10220048, Compound AA25)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc2CCCCc2s1
Show InChI InChI=1S/C26H30N4O6S2/c1-36-26(32)29-21(15-17-7-3-2-4-8-17)24(31)27-22(25-28-20-9-5-6-10-23(20)37-25)16-18-11-13-19(14-12-18)30-38(33,34)35/h2-4,7-8,11-14,21-22,30H,5-6,9-10,15-16H2,1H3,(H,27,31)(H,29,32)(H,33,34,35)/t21-,22-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359188
PNG
(US10220048, Compound AA98)
Show SMILES OS(=O)(=O)Nc1ccc(C[C@H](Nc2nnc(Cc3ccccc3)s2)c2csc(n2)-c2cccs2)cc1
Show InChI InChI=1S/C24H21N5O3S4/c30-36(31,32)29-18-10-8-17(9-11-18)13-19(20-15-34-23(25-20)21-7-4-12-33-21)26-24-28-27-22(35-24)14-16-5-2-1-3-6-16/h1-12,15,19,29H,13-14H2,(H,26,28)(H,30,31,32)/t19-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359132
PNG
(US10220048, Compound AA42 | US10220048, Compound A...)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C24H36N4O6S2/c1-7-17-14-35-22(25-17)20(13-16-8-10-18(11-9-16)28-36(31,32)33)26-21(29)19(12-15(2)3)27-23(30)34-24(4,5)6/h8-11,14-15,19-20,28H,7,12-13H2,1-6H3,(H,26,29)(H,27,30)(H,31,32,33)/t19-,20-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359103
PNG
(US10220048, Compound AA13)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(C)c(C)s1
Show InChI InChI=1S/C24H28N4O6S2/c1-15-16(2)35-23(25-15)21(14-18-9-11-19(12-10-18)28-36(31,32)33)26-22(29)20(27-24(30)34-3)13-17-7-5-4-6-8-17/h4-12,20-21,28H,13-14H2,1-3H3,(H,26,29)(H,27,30)(H,31,32,33)/t20-,21-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359107
PNG
(US10220048, Compound AA17)
Show SMILES COCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC
Show InChI InChI=1S/C24H28N4O7S2/c1-34-14-19-15-36-23(25-19)21(13-17-8-10-18(11-9-17)28-37(31,32)33)26-22(29)20(27-24(30)35-2)12-16-6-4-3-5-7-16/h3-11,15,20-21,28H,12-14H2,1-2H3,(H,26,29)(H,27,30)(H,31,32,33)/t20-,21-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359098
PNG
(US10220048, Compound AA8)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(C)cs1
Show InChI InChI=1S/C23H26N4O6S2/c1-15-14-34-22(24-15)20(13-17-8-10-18(11-9-17)27-35(30,31)32)25-21(28)19(26-23(29)33-2)12-16-6-4-3-5-7-16/h3-11,14,19-20,27H,12-13H2,1-2H3,(H,25,28)(H,26,29)(H,30,31,32)/t19-,20-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359119
PNG
(US10220048, Compound AA29)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(C)n1
Show InChI InChI=1S/C23H26N4O6S2/c1-15-24-21(14-34-15)19(12-17-8-10-18(11-9-17)27-35(30,31)32)25-22(28)20(26-23(29)33-2)13-16-6-4-3-5-7-16/h3-11,14,19-20,27H,12-13H2,1-2H3,(H,25,28)(H,26,29)(H,30,31,32)/t19-,20-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359114
PNG
(US10220048, Compound AA24)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc2CCCc2s1
Show InChI InChI=1S/C25H28N4O6S2/c1-35-25(31)28-20(14-16-6-3-2-4-7-16)23(30)26-21(24-27-19-8-5-9-22(19)36-24)15-17-10-12-18(13-11-17)29-37(32,33)34/h2-4,6-7,10-13,20-21,29H,5,8-9,14-15H2,1H3,(H,26,30)(H,28,31)(H,32,33,34)/t20-,21-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359129
PNG
(US10220048, Compound AA39)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(C)=O
Show InChI InChI=1S/C24H28N4O5S2/c1-3-19-15-34-24(26-19)22(14-18-9-11-20(12-10-18)28-35(31,32)33)27-23(30)21(25-16(2)29)13-17-7-5-4-6-8-17/h4-12,15,21-22,28H,3,13-14H2,1-2H3,(H,25,29)(H,27,30)(H,31,32,33)/t21-,22-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359189
PNG
(US10220048, Compound AA99)
Show SMILES COC(=O)Cc1nnc(N[C@@H](Cc2ccc(NS(O)(=O)=O)cc2)c2csc(n2)-c2cccs2)s1
Show InChI InChI=1S/C20H19N5O5S4/c1-30-18(26)10-17-23-24-20(33-17)22-14(15-11-32-19(21-15)16-3-2-8-31-16)9-12-4-6-13(7-5-12)25-34(27,28)29/h2-8,11,14,25H,9-10H2,1H3,(H,22,24)(H,27,28,29)/t14-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359182
PNG
(US10220048, Compound AA92)
Show SMILES CCN1CCN(CC(=O)N[C@@H](Cc2ccc(NS(O)(=O)=O)cc2)c2nc(CC)cs2)C(=O)C1=O
Show InChI InChI=1S/C21H27N5O6S2/c1-3-15-13-33-19(22-15)17(11-14-5-7-16(8-6-14)24-34(30,31)32)23-18(27)12-26-10-9-25(4-2)20(28)21(26)29/h5-8,13,17,24H,3-4,9-12H2,1-2H3,(H,23,27)(H,30,31,32)/t17-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359183
PNG
(US10220048, Compound AA93)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)Cn1cc(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C20H23N5O6S2/c1-3-14-11-32-19(21-14)16(8-13-4-6-15(7-5-13)24-33(29,30)31)22-17(26)10-25-9-12(2)18(27)23-20(25)28/h4-7,9,11,16,24H,3,8,10H2,1-2H3,(H,22,26)(H,23,27,28)(H,29,30,31)/t16-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359122
PNG
(US10220048, Compound AA32)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(CS(=O)(=O)C(C)(C)C)n1
Show InChI InChI=1S/C27H34N4O8S3/c1-27(2,3)41(34,35)17-24-28-23(16-40-24)21(14-19-10-12-20(13-11-19)31-42(36,37)38)29-25(32)22(30-26(33)39-4)15-18-8-6-5-7-9-18/h5-13,16,21-22,31H,14-15,17H2,1-4H3,(H,29,32)(H,30,33)(H,36,37,38)/t21-,22-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359175
PNG
(US10220048, Compound AA85)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)CCc1ccccc1
Show InChI InChI=1S/C22H25N3O4S2/c1-2-18-15-30-22(23-18)20(24-21(26)13-10-16-6-4-3-5-7-16)14-17-8-11-19(12-9-17)25-31(27,28)29/h3-9,11-12,15,20,25H,2,10,13-14H2,1H3,(H,24,26)(H,27,28,29)/t20-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359185
PNG
(US10220048, Compound AA95)
Show SMILES Cc1nnc(N[C@@H](Cc2ccc(NS(O)(=O)=O)cc2)c2csc(n2)-c2ccccc2)s1
Show InChI InChI=1S/C20H19N5O3S3/c1-13-23-24-20(30-13)22-17(11-14-7-9-16(10-8-14)25-31(26,27)28)18-12-29-19(21-18)15-5-3-2-4-6-15/h2-10,12,17,25H,11H2,1H3,(H,22,24)(H,26,27,28)/t17-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359179
PNG
(US10220048, Compound AA89)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)CCc1ccccc1OC
Show InChI InChI=1S/C23H27N3O5S2/c1-3-18-15-32-23(24-18)20(14-16-8-11-19(12-9-16)26-33(28,29)30)25-22(27)13-10-17-6-4-5-7-21(17)31-2/h4-9,11-12,15,20,26H,3,10,13-14H2,1-2H3,(H,25,27)(H,28,29,30)/t20-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359135
PNG
(US10220048, Compound AA45)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C20H28N4O6S2/c1-5-14-11-31-19(21-14)16(22-18(25)17(12(2)3)23-20(26)30-4)10-13-6-8-15(9-7-13)24-32(27,28)29/h6-9,11-12,16-17,24H,5,10H2,1-4H3,(H,22,25)(H,23,26)(H,27,28,29)/t16-,17-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359128
PNG
(US10220048, Compound AA38)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)-c1cnccn1
Show InChI InChI=1S/C26H26N6O6S2/c1-38-26(34)31-21(14-17-5-3-2-4-6-17)24(33)29-20(13-18-7-9-19(10-8-18)32-40(35,36)37)23-16-39-25(30-23)22-15-27-11-12-28-22/h2-12,15-16,20-21,32H,13-14H2,1H3,(H,29,33)(H,31,34)(H,35,36,37)/t20-,21-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359092
PNG
(US10220048, Compound AA2)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C27H34N4O6S2/c1-5-20-17-38-25(28-20)23(16-19-11-13-21(14-12-19)31-39(34,35)36)29-24(32)22(15-18-9-7-6-8-10-18)30-26(33)37-27(2,3)4/h6-14,17,22-23,31H,5,15-16H2,1-4H3,(H,29,32)(H,30,33)(H,34,35,36)/t22-,23+/m1/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359126
PNG
(US10220048, Compound AA36)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)-c1sccc1C
Show InChI InChI=1S/C27H28N4O6S3/c1-17-12-13-38-24(17)26-29-23(16-39-26)21(14-19-8-10-20(11-9-19)31-40(34,35)36)28-25(32)22(30-27(33)37-2)15-18-6-4-3-5-7-18/h3-13,16,21-22,31H,14-15H2,1-2H3,(H,28,32)(H,30,33)(H,34,35,36)/t21-,22-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359124
PNG
(US10220048, Compound AA34)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)-c1cccs1
Show InChI InChI=1S/C26H26N4O6S3/c1-36-26(32)29-21(15-17-6-3-2-4-7-17)24(31)27-20(22-16-38-25(28-22)23-8-5-13-37-23)14-18-9-11-19(12-10-18)30-39(33,34)35/h2-13,16,20-21,30H,14-15H2,1H3,(H,27,31)(H,29,32)(H,33,34,35)/t20-,21-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359102
PNG
(US10220048, Compound AA12)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)C1CCCCC1
Show InChI InChI=1S/C28H34N4O6S2/c1-38-28(34)31-23(16-19-8-4-2-5-9-19)26(33)29-24(17-20-12-14-22(15-13-20)32-40(35,36)37)27-30-25(18-39-27)21-10-6-3-7-11-21/h2,4-5,8-9,12-15,18,21,23-24,32H,3,6-7,10-11,16-17H2,1H3,(H,29,33)(H,31,34)(H,35,36,37)/t23-,24-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359139
PNG
(US10220048, Compound AA49)
Show SMILES COC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1cccs1
Show InChI InChI=1S/C23H28N4O6S3/c1-14(2)11-17(26-23(29)33-3)21(28)24-18(22-25-19(13-35-22)20-5-4-10-34-20)12-15-6-8-16(9-7-15)27-36(30,31)32/h4-10,13-14,17-18,27H,11-12H2,1-3H3,(H,24,28)(H,26,29)(H,30,31,32)/t17-,18-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359110
PNG
(US10220048, Compound AA20)
Show SMILES CCc1nc(sc1-c1ccccc1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC
Show InChI InChI=1S/C30H32N4O6S2/c1-3-24-27(22-12-8-5-9-13-22)41-29(32-24)26(19-21-14-16-23(17-15-21)34-42(37,38)39)31-28(35)25(33-30(36)40-2)18-20-10-6-4-7-11-20/h4-17,25-26,34H,3,18-19H2,1-2H3,(H,31,35)(H,33,36)(H,37,38,39)/t25-,26-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359112
PNG
(US10220048, Compound AA22)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1cccs1
Show InChI InChI=1S/C26H26N4O6S3/c1-36-26(32)29-20(14-17-6-3-2-4-7-17)24(31)27-21(25-28-22(16-38-25)23-8-5-13-37-23)15-18-9-11-19(12-10-18)30-39(33,34)35/h2-13,16,20-21,30H,14-15H2,1H3,(H,27,31)(H,29,32)(H,33,34,35)/t20-,21-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359095
PNG
(US10220048, Compound AA5)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C31H34N4O6S2/c1-31(2,3)41-30(37)34-26(19-21-10-6-4-7-11-21)28(36)32-25(18-22-14-16-24(17-15-22)35-43(38,39)40)27-20-42-29(33-27)23-12-8-5-9-13-23/h4-17,20,25-26,35H,18-19H2,1-3H3,(H,32,36)(H,34,37)(H,38,39,40)/t25-,26-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359125
PNG
(US10220048, Compound AA35)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)-c1sccc1Cl
Show InChI InChI=1S/C26H25ClN4O6S3/c1-37-26(33)30-21(14-16-5-3-2-4-6-16)24(32)28-20(13-17-7-9-18(10-8-17)31-40(34,35)36)22-15-39-25(29-22)23-19(27)11-12-38-23/h2-12,15,20-21,31H,13-14H2,1H3,(H,28,32)(H,30,33)(H,34,35,36)/t20-,21-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359094
PNG
(US10220048, Compound AA4)
Show SMILES CC(C)(C)OC(=O)NC[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C32H36N4O6S2/c1-32(2,3)42-31(38)33-20-25(18-22-10-6-4-7-11-22)29(37)34-27(19-23-14-16-26(17-15-23)36-44(39,40)41)30-35-28(21-43-30)24-12-8-5-9-13-24/h4-17,21,25,27,36H,18-20H2,1-3H3,(H,33,38)(H,34,37)(H,39,40,41)/t25-,27-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359116
PNG
(US10220048, Compound AA26)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccc(Cl)s1
Show InChI InChI=1S/C26H25ClN4O6S3/c1-37-26(33)30-19(13-16-5-3-2-4-6-16)24(32)28-20(14-17-7-9-18(10-8-17)31-40(34,35)36)25-29-21(15-38-25)22-11-12-23(27)39-22/h2-12,15,19-20,31H,13-14H2,1H3,(H,28,32)(H,30,33)(H,34,35,36)/t19-,20-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359181
PNG
(US10220048, Compound AA91)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)CCc1ccc(OC)cc1
Show InChI InChI=1S/C23H27N3O5S2/c1-3-18-15-32-23(24-18)21(14-17-4-9-19(10-5-17)26-33(28,29)30)25-22(27)13-8-16-6-11-20(31-2)12-7-16/h4-7,9-12,15,21,26H,3,8,13-14H2,1-2H3,(H,25,27)(H,28,29,30)/t21-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359132
PNG
(US10220048, Compound AA42 | US10220048, Compound A...)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C24H36N4O6S2/c1-7-17-14-35-22(25-17)20(13-16-8-10-18(11-9-16)28-36(31,32)33)26-21(29)19(12-15(2)3)27-23(30)34-24(4,5)6/h8-11,14-15,19-20,28H,7,12-13H2,1-6H3,(H,26,29)(H,27,30)(H,31,32,33)/t19-,20-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359097
PNG
(US10220048, Compound AA7)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nccs1
Show InChI InChI=1S/C22H24N4O6S2/c1-32-22(28)25-18(13-15-5-3-2-4-6-15)20(27)24-19(21-23-11-12-33-21)14-16-7-9-17(10-8-16)26-34(29,30)31/h2-12,18-19,26H,13-14H2,1H3,(H,24,27)(H,25,28)(H,29,30,31)/t18-,19-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359174
PNG
(US10220048, Compound AA84)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)Cc1cccc(OC)c1
Show InChI InChI=1S/C22H25N3O5S2/c1-3-17-14-31-22(23-17)20(12-15-7-9-18(10-8-15)25-32(27,28)29)24-21(26)13-16-5-4-6-19(11-16)30-2/h4-11,14,20,25H,3,12-13H2,1-2H3,(H,24,26)(H,27,28,29)/t20-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359180
PNG
(US10220048, Compound AA90)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)CCc1cccc(OC)c1
Show InChI InChI=1S/C23H27N3O5S2/c1-3-18-15-32-23(24-18)21(14-17-7-10-19(11-8-17)26-33(28,29)30)25-22(27)12-9-16-5-4-6-20(13-16)31-2/h4-8,10-11,13,15,21,26H,3,9,12,14H2,1-2H3,(H,25,27)(H,28,29,30)/t21-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359166
PNG
(US10220048, Compound AA76)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)Cc1ccccc1F
Show InChI InChI=1S/C21H22FN3O4S2/c1-2-16-13-30-21(23-16)19(24-20(26)12-15-5-3-4-6-18(15)22)11-14-7-9-17(10-8-14)25-31(27,28)29/h3-10,13,19,25H,2,11-12H2,1H3,(H,24,26)(H,27,28,29)/t19-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359173
PNG
(US10220048, Compound AA83)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)Cc1ccccc1O
Show InChI InChI=1S/C21H23N3O5S2/c1-2-16-13-30-21(22-16)18(23-20(26)12-15-5-3-4-6-19(15)25)11-14-7-9-17(10-8-14)24-31(27,28)29/h3-10,13,18,24-25H,2,11-12H2,1H3,(H,23,26)(H,27,28,29)/t18-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359134
PNG
(US10220048, Compound AA44)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)CNC(=O)OC
Show InChI InChI=1S/C17H22N4O6S2/c1-3-12-10-28-16(19-12)14(20-15(22)9-18-17(23)27-2)8-11-4-6-13(7-5-11)21-29(24,25)26/h4-7,10,14,21H,3,8-9H2,1-2H3,(H,18,23)(H,20,22)(H,24,25,26)/t14-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359156
PNG
(US10220048, Compound AA66)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)C(C)(C)C
Show InChI InChI=1S/C20H29N3O5S2/c1-19(2,3)16-12-29-17(22-16)15(21-18(24)28-20(4,5)6)11-13-7-9-14(10-8-13)23-30(25,26)27/h7-10,12,15,23H,11H2,1-6H3,(H,21,24)(H,25,26,27)/t15-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359133
PNG
(US10220048, Compound AA43 | US10220048, Compound A...)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)CNC(=O)OC(C)(C)C
Show InChI InChI=1S/C20H28N4O6S2/c1-5-14-12-31-18(22-14)16(23-17(25)11-21-19(26)30-20(2,3)4)10-13-6-8-15(9-7-13)24-32(27,28)29/h6-9,12,16,24H,5,10-11H2,1-4H3,(H,21,26)(H,23,25)(H,27,28,29)/t16-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359168
PNG
(US10220048, Compound AA78)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)Cc1cccc(F)c1F
Show InChI InChI=1S/C21H21F2N3O4S2/c1-2-15-12-31-21(24-15)18(10-13-6-8-16(9-7-13)26-32(28,29)30)25-19(27)11-14-4-3-5-17(22)20(14)23/h3-9,12,18,26H,2,10-11H2,1H3,(H,25,27)(H,28,29,30)/t18-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359133
PNG
(US10220048, Compound AA43 | US10220048, Compound A...)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)CNC(=O)OC(C)(C)C
Show InChI InChI=1S/C20H28N4O6S2/c1-5-14-12-31-18(22-14)16(23-17(25)11-21-19(26)30-20(2,3)4)10-13-6-8-15(9-7-13)24-32(27,28)29/h6-9,12,16,24H,5,10-11H2,1-4H3,(H,21,26)(H,23,25)(H,27,28,29)/t16-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359176
PNG
(US10220048, Compound AA86)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)Cc1ccc(OC)c(OC)c1
Show InChI InChI=1S/C23H27N3O6S2/c1-4-17-14-33-23(24-17)19(11-15-5-8-18(9-6-15)26-34(28,29)30)25-22(27)13-16-7-10-20(31-2)21(12-16)32-3/h5-10,12,14,19,26H,4,11,13H2,1-3H3,(H,25,27)(H,28,29,30)/t19-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359093
PNG
(US10220048, Compound AA3)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](CNC(=O)OC(C)(C)C)Cc1ccccc1
Show InChI InChI=1S/C28H36N4O6S2/c1-5-22-18-39-26(30-22)24(16-20-11-13-23(14-12-20)32-40(35,36)37)31-25(33)21(15-19-9-7-6-8-10-19)17-29-27(34)38-28(2,3)4/h6-14,18,21,24,32H,5,15-17H2,1-4H3,(H,29,34)(H,31,33)(H,35,36,37)/t21-,24-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359171
PNG
(US10220048, Compound AA81)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)Cc1cccc(Cl)c1
Show InChI InChI=1S/C21H22ClN3O4S2/c1-2-17-13-30-21(23-17)19(24-20(26)12-15-4-3-5-16(22)10-15)11-14-6-8-18(9-7-14)25-31(27,28)29/h3-10,13,19,25H,2,11-12H2,1H3,(H,24,26)(H,27,28,29)/t19-/m0/s1
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n/an/a 33n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359154
PNG
(US10220048, Compound AA64)
Show SMILES Cc1nc(cs1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C17H23N3O5S2/c1-11-18-15(10-26-11)14(19-16(21)25-17(2,3)4)9-12-5-7-13(8-6-12)20-27(22,23)24/h5-8,10,14,20H,9H2,1-4H3,(H,19,21)(H,22,23,24)/t14-/m0/s1
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n/an/a 33n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359177
PNG
(US10220048, Compound AA87)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)Cc1cccc(OC)c1OC
Show InChI InChI=1S/C23H27N3O6S2/c1-4-17-14-33-23(24-17)19(12-15-8-10-18(11-9-15)26-34(28,29)30)25-21(27)13-16-6-5-7-20(31-2)22(16)32-3/h5-11,14,19,26H,4,12-13H2,1-3H3,(H,25,27)(H,28,29,30)/t19-/m0/s1
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n/an/a 37n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359155
PNG
(US10220048, Compound AA65)
Show SMILES CCCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C19H27N3O5S2/c1-5-6-15-12-28-17(20-15)16(21-18(23)27-19(2,3)4)11-13-7-9-14(10-8-13)22-29(24,25)26/h7-10,12,16,22H,5-6,11H2,1-4H3,(H,21,23)(H,24,25,26)/t16-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359172
PNG
(US10220048, Compound AA82)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)Cc1cccc(O)c1
Show InChI InChI=1S/C21H23N3O5S2/c1-2-16-13-30-21(22-16)19(23-20(26)12-15-4-3-5-18(25)10-15)11-14-6-8-17(9-7-14)24-31(27,28)29/h3-10,13,19,24-25H,2,11-12H2,1H3,(H,23,26)(H,27,28,29)/t19-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359146
PNG
(US10220048, Compound AA56)
Show SMILES CC(C)(C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C22H25N3O4S2/c1-22(2,3)21(26)24-18(13-15-9-11-17(12-10-15)25-31(27,28)29)20-23-19(14-30-20)16-7-5-4-6-8-16/h4-12,14,18,25H,13H2,1-3H3,(H,24,26)(H,27,28,29)/t18-/m0/s1
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n/an/a 42n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359184
PNG
(US10220048, Compound AA94)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C21H21N3O6S2/c1-2-15-11-31-21(22-15)17(9-13-3-6-16(7-4-13)24-32(26,27)28)23-20(25)14-5-8-18-19(10-14)30-12-29-18/h3-8,10-11,17,24H,2,9,12H2,1H3,(H,23,25)(H,26,27,28)/t17-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359164
PNG
(US10220048, Compound AA74)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccsc1
Show InChI InChI=1S/C20H23N3O5S3/c1-20(2,3)28-19(24)22-16(18-21-17(12-30-18)14-8-9-29-11-14)10-13-4-6-15(7-5-13)23-31(25,26)27/h4-9,11-12,16,23H,10H2,1-3H3,(H,22,24)(H,25,26,27)/t16-/m0/s1
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n/an/a 45n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359186
PNG
(US10220048, Compound AA96)
Show SMILES OS(=O)(=O)Nc1ccc(C[C@H](Nc2nnc(s2)-c2ccccc2)c2csc(n2)-c2ccccc2)cc1
Show InChI InChI=1S/C25H21N5O3S3/c31-36(32,33)30-20-13-11-17(12-14-20)15-21(22-16-34-23(26-22)18-7-3-1-4-8-18)27-25-29-28-24(35-25)19-9-5-2-6-10-19/h1-14,16,21,30H,15H2,(H,27,29)(H,31,32,33)/t21-/m0/s1
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n/an/a 46n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359141
PNG
(US10220048, Compound AA51)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C22H25N3O5S2/c1-22(2,3)30-21(26)24-18(13-15-9-11-17(12-10-15)25-32(27,28)29)20-23-19(14-31-20)16-7-5-4-6-8-16/h4-12,14,18,25H,13H2,1-3H3,(H,24,26)(H,27,28,29)/t18-/m0/s1
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n/an/a 49n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359091
PNG
(US10220048, Compound AA1 | US10220048, Compound AA...)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C21H23N3O4S2/c1-2-17-14-29-21(22-17)19(23-20(25)13-15-6-4-3-5-7-15)12-16-8-10-18(11-9-16)24-30(26,27)28/h3-11,14,19,24H,2,12-13H2,1H3,(H,23,25)(H,26,27,28)/t19-/m0/s1
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n/an/a 50n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359170
PNG
(US10220048, Compound AA80)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)Cc1ccccc1Cl
Show InChI InChI=1S/C21H22ClN3O4S2/c1-2-16-13-30-21(23-16)19(24-20(26)12-15-5-3-4-6-18(15)22)11-14-7-9-17(10-8-14)25-31(27,28)29/h3-10,13,19,25H,2,11-12H2,1H3,(H,24,26)(H,27,28,29)/t19-/m0/s1
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n/an/a 56n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359169
PNG
(US10220048, Compound AA79)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C21H21F2N3O4S2/c1-2-15-12-31-21(24-15)19(10-13-3-6-16(7-4-13)26-32(28,29)30)25-20(27)11-14-5-8-17(22)18(23)9-14/h3-9,12,19,26H,2,10-11H2,1H3,(H,25,27)(H,28,29,30)/t19-/m0/s1
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n/an/a 75n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359143
PNG
(US10220048, Compound AA53)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)C(C)(C)C
Show InChI InChI=1S/C18H25N3O4S2/c1-5-13-11-26-16(19-13)15(20-17(22)18(2,3)4)10-12-6-8-14(9-7-12)21-27(23,24)25/h6-9,11,15,21H,5,10H2,1-4H3,(H,20,22)(H,23,24,25)/t15-/m0/s1
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n/an/a 85n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359148
PNG
(US10220048, Compound AA58)
Show SMILES COc1ccc(-c2csc(n2)[C@H](Cc2ccc(NS(O)(=O)=O)cc2)NC(=O)C(C)(C)C)c(CO)c1
Show InChI InChI=1S/C24H29N3O6S2/c1-24(2,3)23(29)26-20(11-15-5-7-17(8-6-15)27-35(30,31)32)22-25-21(14-34-22)19-10-9-18(33-4)12-16(19)13-28/h5-10,12,14,20,27-28H,11,13H2,1-4H3,(H,26,29)(H,30,31,32)/t20-/m0/s1
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n/an/a 86n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359152
PNG
(US10220048, Compound AA62)
Show SMILES Cc1sc(nc1-c1ccccc1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)C(C)(C)C
Show InChI InChI=1S/C23H27N3O4S2/c1-15-20(17-8-6-5-7-9-17)25-21(31-15)19(24-22(27)23(2,3)4)14-16-10-12-18(13-11-16)26-32(28,29)30/h5-13,19,26H,14H2,1-4H3,(H,24,27)(H,28,29,30)/t19-/m0/s1
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n/an/a 98n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359147
PNG
(US10220048, Compound AA57)
Show SMILES COc1cccc(c1)-c1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)C(C)(C)C
Show InChI InChI=1S/C23H27N3O5S2/c1-23(2,3)22(27)25-19(12-15-8-10-17(11-9-15)26-33(28,29)30)21-24-20(14-32-21)16-6-5-7-18(13-16)31-4/h5-11,13-14,19,26H,12H2,1-4H3,(H,25,27)(H,28,29,30)/t19-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359142
PNG
(US10220048, Compound AA52)
Show SMILES Cc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)C(C)(C)C
Show InChI InChI=1S/C17H23N3O4S2/c1-11-10-25-15(18-11)14(19-16(21)17(2,3)4)9-12-5-7-13(8-6-12)20-26(22,23)24/h5-8,10,14,20H,9H2,1-4H3,(H,19,21)(H,22,23,24)/t14-/m0/s1
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n/an/a 112n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359149
PNG
(US10220048, Compound AA59)
Show SMILES CC(C)(C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(Cc2ccccc2)cs1
Show InChI InChI=1S/C23H27N3O4S2/c1-23(2,3)22(27)25-20(14-17-9-11-18(12-10-17)26-32(28,29)30)21-24-19(15-31-21)13-16-7-5-4-6-8-16/h4-12,15,20,26H,13-14H2,1-3H3,(H,25,27)(H,28,29,30)/t20-/m0/s1
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n/an/a 113n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359150
PNG
(US10220048, Compound AA60)
Show SMILES CC(C)(C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(Cc2cccc(CO)c2)cs1
Show InChI InChI=1S/C24H29N3O5S2/c1-24(2,3)23(29)26-21(13-16-7-9-19(10-8-16)27-34(30,31)32)22-25-20(15-33-22)12-17-5-4-6-18(11-17)14-28/h4-11,15,21,27-28H,12-14H2,1-3H3,(H,26,29)(H,30,31,32)/t21-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359160
PNG
(US10220048, Compound AA70)
Show SMILES COC(=O)Cc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C19H25N3O7S2/c1-19(2,3)29-18(24)21-15(17-20-14(11-30-17)10-16(23)28-4)9-12-5-7-13(8-6-12)22-31(25,26)27/h5-8,11,15,22H,9-10H2,1-4H3,(H,21,24)(H,25,26,27)/t15-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359151
PNG
(US10220048, Compound AA61)
Show SMILES CC(C)(C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccc2OCCOc2c1
Show InChI InChI=1S/C24H27N3O6S2/c1-24(2,3)23(28)26-18(12-15-4-7-17(8-5-15)27-35(29,30)31)22-25-19(14-34-22)16-6-9-20-21(13-16)33-11-10-32-20/h4-9,13-14,18,27H,10-12H2,1-3H3,(H,26,28)(H,29,30,31)/t18-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359159
PNG
(US10220048, Compound AA69)
Show SMILES CCOC(=O)Cc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C20H27N3O7S2/c1-5-29-17(24)11-15-12-31-18(21-15)16(22-19(25)30-20(2,3)4)10-13-6-8-14(9-7-13)23-32(26,27)28/h6-9,12,16,23H,5,10-11H2,1-4H3,(H,22,25)(H,26,27,28)/t16-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359157
PNG
(US10220048, Compound AA67)
Show SMILES COCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C18H25N3O6S2/c1-18(2,3)27-17(22)20-15(16-19-14(10-26-4)11-28-16)9-12-5-7-13(8-6-12)21-29(23,24)25/h5-8,11,15,21H,9-10H2,1-4H3,(H,20,22)(H,23,24,25)/t15-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359163
PNG
(US10220048, Compound AA73)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N3O5S2/c1-22(2,3)34-21(30)28-18(11-14-7-9-17(10-8-14)29-36(31,32)33)20-27-19(13-35-20)15-5-4-6-16(12-15)23(24,25)26/h4-10,12-13,18,29H,11H2,1-3H3,(H,28,30)(H,31,32,33)/t18-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359144
PNG
(US10220048, Compound AA54)
Show SMILES CC(C)(C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(CO)cs1
Show InChI InChI=1S/C17H23N3O5S2/c1-17(2,3)16(22)19-14(15-18-13(9-21)10-26-15)8-11-4-6-12(7-5-11)20-27(23,24)25/h4-7,10,14,20-21H,8-9H2,1-3H3,(H,19,22)(H,23,24,25)/t14-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359162
PNG
(US10220048, Compound AA72)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1ncc(s1)-c1ccccc1
Show InChI InChI=1S/C22H25N3O5S2/c1-22(2,3)30-21(26)24-18(13-15-9-11-17(12-10-15)25-32(27,28)29)20-23-14-19(31-20)16-7-5-4-6-8-16/h4-12,14,18,25H,13H2,1-3H3,(H,24,26)(H,27,28,29)/t18-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359153
PNG
(US10220048, Compound AA63)
Show SMILES CC(C)(C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H29N3O4S2/c1-28(2,3)27(32)30-24(17-19-9-15-23(16-10-19)31-37(33,34)35)26-29-25(18-36-26)22-13-11-21(12-14-22)20-7-5-4-6-8-20/h4-16,18,24,31H,17H2,1-3H3,(H,30,32)(H,33,34,35)/t24-/m0/s1
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359161
PNG
(US10220048, Compound AA71)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(OC(=O)C(C)(C)C)n1
Show InChI InChI=1S/C21H29N3O7S2/c1-20(2,3)17(25)30-19-23-16(12-32-19)15(22-18(26)31-21(4,5)6)11-13-7-9-14(10-8-13)24-33(27,28)29/h7-10,12,15,24H,11H2,1-6H3,(H,22,26)(H,27,28,29)/t15-/m0/s1
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n/an/a 555n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359145
PNG
(US10220048, Compound AA55)
Show SMILES CCOC(=O)c1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)C(C)(C)C
Show InChI InChI=1S/C19H25N3O6S2/c1-5-28-17(23)15-11-29-16(20-15)14(21-18(24)19(2,3)4)10-12-6-8-13(9-7-12)22-30(25,26)27/h6-9,11,14,22H,5,10H2,1-4H3,(H,21,24)(H,25,26,27)/t14-/m0/s1
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n/an/a 584n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359158
PNG
(US10220048, Compound AA68)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(CO)cs1
Show InChI InChI=1S/C17H23N3O6S2/c1-17(2,3)26-16(22)19-14(15-18-13(9-21)10-27-15)8-11-4-6-12(7-5-11)20-28(23,24)25/h4-7,10,14,20-21H,8-9H2,1-3H3,(H,19,22)(H,23,24,25)/t14-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 644n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359123
PNG
(US10220048, Compound AA33)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C28H28N4O6S2/c1-38-28(34)31-24(17-19-8-4-2-5-9-19)26(33)29-23(16-20-12-14-22(15-13-20)32-40(35,36)37)25-18-39-27(30-25)21-10-6-3-7-11-21/h2-15,18,23-24,32H,16-17H2,1H3,(H,29,33)(H,31,34)(H,35,36,37)/t23-,24-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 700n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359111
PNG
(US10220048, Compound AA21)
Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C28H28N4O6S2/c1-38-28(34)31-23(16-19-8-4-2-5-9-19)26(33)29-24(17-20-12-14-22(15-13-20)32-40(35,36)37)27-30-25(18-39-27)21-10-6-3-7-11-21/h2-15,18,23-24,32H,16-17H2,1H3,(H,29,33)(H,31,34)(H,35,36,37)/t23-,24-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<2.00E+3n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM359190
PNG
(US10220048, Compound AA100)
Show SMILES Cc1nc(Cc2nnc(N[C@@H](Cc3ccc(NS(O)(=O)=O)cc3)c3csc(n3)-c3cccs3)s2)cs1
Show InChI InChI=1S/C22H20N6O3S5/c1-13-23-16(11-33-13)10-20-26-27-22(35-20)25-17(18-12-34-21(24-18)19-3-2-8-32-19)9-14-4-6-15(7-5-14)28-36(29,30)31/h2-8,11-12,17,28H,9-10H2,1H3,(H,25,27)(H,29,30,31)/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 9.00E+3n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...


US Patent US10220048 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%