Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359566![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359569![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359568![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359544![]() (4-{(6R or S)-1-({2- chloro-6-[1- (difluoromethyl)c...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359545![]() (4-{(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359567![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359543![]() (4-[(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359570![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359548![]() (4-{(6R or S)-1-({2- chloro-6-[1- (difluoromethyl)c...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359571![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)c...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359535![]() (US10221142, Example 21A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359547![]() (4-[(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359582![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359577![]() (4-[(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359540![]() (4-[(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359565![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359539![]() (4-{(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359586![]() (4-{(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359551![]() (4-[(6R or S)-1-({2- chloro-6-[1- (difluoromethyl)c...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359550![]() (4-[(6R or S)-1-({2- chloro-6-[1- (difluoromethyl)c...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359578![]() (4-[(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359552![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359564![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359584![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359574![]() (4-[(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359541![]() (4-[(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359541![]() (4-[(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359555![]() ((R or S)-4-(6-(((1H- pyrazol-5- yl)methyl)(methyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359579![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359556![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359510![]() (4-(1-(2-chloro-6- cyclopropylbenzoyl)- 6-(3- metho...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359557![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359559![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359573![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359585![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359587![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359572![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359558![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359538![]() (4-[(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359576![]() (4-[(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359601![]() (US10221142, Example 32A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359537![]() (4-{(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359546![]() (4-[(6R or S)-6-[(3- azetidin-1- yl)pyrrolidin-1- y...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359588![]() ((R or S)-4-(1-(2- (difluoromethyl)-6- (1- (trifluo...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359575![]() (4-[(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359563![]() ((R or S)-4-(6-((2- (1H-imidazol-1- yl)ethyl)(methy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359560![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359536![]() ((R or S)-4-(1-(2- chloro-6-cyclopropyl- 3-fluorobe...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359562![]() ((R or S)-4-(6-((2- (1H-pyrazol-1- yl)ethyl)(methyl...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359506![]() (US10221142, Example 9A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359561![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359487![]() (4-(1-(2-chloro-6- cyclopropylbenzoyl)-4,5,6,7- tet...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359554![]() (4-((6R or S)-6-((1- (1H-pyrazol-5- yl)ethyl)(methy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359501![]() (US10221142, Example 6A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359607![]() (4-[1-({2-chloro-6-[1- (trifluoromethyl)cyclo propy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359488![]() (4-(1-(2-chloro-6- cyclopropylbenzoyl)-4,5,6,7- tet...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359497![]() (US10221142, Example 2A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359602![]() (US10221142, Example 33A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359600![]() (US10221142, Example 31A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359502![]() (4-(6-(azetidine-1-carbonyl)-1- (2-chloro-6- cyclop...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359495![]() (4-(1-(2-chloro-6- cyclobutylbenzoyl)-4,5,6,7- tetr...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359549![]() (4-{(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359606![]() (US10221142, Example 37A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359581![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359507![]() (4-[1-({2- chloro-6-[1- (trifluoro- methyl) cyclopr...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359489![]() (4-(1-(2-chloro-6- cyclopropylbenzoyl)-6- hydroxy-4...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359512![]() (4-(1-(2-chloro-6-(1- cyanocyclopropyl) benzoyl)-6-...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359484![]() (US10221142, Example 1A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359516![]() (4-(1-(2-chloro-6-(1- cyanocyclobutyl) benzoyl)-6-(...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359604![]() (US10221142, Example 35A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359580![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359598![]() (US10221142, Example 29A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359518![]() (4-(1-(2-chloro-6- cyclopropylbenzoyl)- 6-(3- metho...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359503![]() (4-(1-(2-chloro-6- cyclopropylbenzoyl)-6- (methylca...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359595![]() (US10221142, Example 27A | US10221142, Example 27B) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359553![]() ((R or S)-4-(1-(2- chloro-6-(1- (trifluoromethyl)cy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359514![]() (4-(1-(2-chloro-6-(1- cyanocyclobutyl) benzoyl)-6-(...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359493![]() (4-(1-(2-chloro-6- cyclopropylbenzoyl)-6-oxo- 4,5,6...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359491![]() (4-(1-(2-chloro-6- cyclopropylbenzoyl)-4-oxo- 4,5,6...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 12.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359592![]() (US10221142, Example 25A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359496![]() (4-(1-(2,6-dichlorobenzoyl)- 4,5,6,7-tetrahydro-1H-...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 13.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359523![]() (US10221142, Example 18A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359492![]() (4-(1-(2-chloro-6- cyclopropylbenzoyl)-6- methoxy-4...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 17.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359593![]() (4-[1-({2-chloro-6-[1- (trifluoromethyl)cyclo- prop...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359533![]() (US10221142, Example 20A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359485![]() (4-(1-(2-chloro-6- (trifluoromethyl)benzoyl)- 1,4,5...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 21.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359494![]() (4-(1-(2-chloro-6- cyclopropylbenzoyl)- 1,4,5,6,7,8...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 21.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359526![]() (US10221142, Example 18D) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359534![]() (4-{1-[(2-chloro-6- cyclopropylphenyl)car bonyl]-4,...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359583![]() ((R or S)-4-(1-(2- chloro-6- cyclopropylbenzoyl)- 6...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359524![]() (US10221142, Example 18B) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359499![]() (US10221142, Example 4A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 56.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359594![]() (US10221142, Example 26A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359590![]() (US10221142, Example 23A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359603![]() (US10221142, Example 34A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359599![]() (US10221142, Example 30A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359527![]() (US10221142, Example 18E) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359505![]() (US10221142, Example 8A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359510![]() (4-(1-(2-chloro-6- cyclopropylbenzoyl)- 6-(3- metho...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359532![]() (US10221142, Example 19C) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359595![]() (US10221142, Example 27A | US10221142, Example 27B) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 121 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359500![]() (US10221142, Example 5A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 141 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359528![]() (US10221142, Example 18F) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359591![]() (US10221142, Example 24A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 159 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359597![]() (US10221142, Example 28A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 166 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359519![]() (US10221142, Example 17A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 185 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359509![]() (US10221142, Example 11A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 187 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359530![]() (US10221142, Example 19A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 223 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359522![]() (US10221142, Example 17D) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 235 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359514![]() (4-(1-(2-chloro-6-(1- cyanocyclobutyl) benzoyl)-6-(...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 294 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359589![]() (US10221142, Example 22A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 332 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359525![]() (US10221142, Example 18C) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 606 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359508![]() (US10221142, Example 10A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 622 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359516![]() (4-(1-(2-chloro-6-(1- cyanocyclobutyl) benzoyl)-6-(...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 625 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359512![]() (4-(1-(2-chloro-6-(1- cyanocyclopropyl) benzoyl)-6-...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 642 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359521![]() (US10221142, Example 17C) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 642 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359498![]() (US10221142, Example 3A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 728 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359531![]() (US10221142, Example 19B) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 773 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359529![]() (US10221142, Example 18G) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 814 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359520![]() (US10221142, Example 17B) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359504![]() (US10221142, Example 7A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359605![]() (US10221142, Example 36A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359490![]() (4-(6-(tert-butoxycarbonyl)-1-(2- chloro-6-cyclopro...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM359486![]() (4-(6-(tert-butoxycarbonyl)-1-(2- chloro-6- (triflu...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I... | US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0 | |||||||||||
More data for this Ligand-Target Pair |