Affinity Data by Patent

Patent code US10221160

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cytochrome P450 3A (Homo sapiens (Human))	BDBM25817 (2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...) Show SMILES OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB US Patent	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Mycovia Pharmaceuticals, Inc. US Patent					Assay Description Pooled human liver microsome suspension (20 mg/mL) was diluted with phosphate buffer to obtain a 5 mg/mL suspension. A solution of NADPH was prepared...				US Patent US10221160 (2019) BindingDB Entry DOI: 10.7270/Q2736T6Q
Mycovia Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM25817 (2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...) Show SMILES OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank US Patent	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Mycovia Pharmaceuticals, Inc. US Patent					Assay Description Pooled human liver microsome suspension (20 mg/mL) was diluted with phosphate buffer to obtain a 5 mg/mL suspension. A solution of NADPH was prepared...				US Patent US10221160 (2019) BindingDB Entry DOI: 10.7270/Q2736T6Q
Mycovia Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 3A (Homo sapiens (Human))	BDBM234945 (US10221160, Voriconazole \| US9556143, 31 \| US95561...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mycovia Pharmaceuticals, Inc. US Patent					Assay Description Pooled human liver microsome suspension (20 mg/mL) was diluted with phosphate buffer to obtain a 5 mg/mL suspension. A solution of NADPH was prepared...				US Patent US10221160 (2019) BindingDB Entry DOI: 10.7270/Q2736T6Q
Mycovia Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM234945 (US10221160, Voriconazole \| US9556143, 31 \| US95561...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mycovia Pharmaceuticals, Inc. US Patent					Assay Description Pooled human liver microsome suspension (20 mg/mL) was diluted with phosphate buffer to obtain a 5 mg/mL suspension. A solution of NADPH was prepared...				US Patent US10221160 (2019) BindingDB Entry DOI: 10.7270/Q2736T6Q
Mycovia Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM234945 (US10221160, Voriconazole \| US9556143, 31 \| US95561...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mycovia Pharmaceuticals, Inc. US Patent					Assay Description Pooled human liver microsome suspension (20 mg/mL) was diluted with phosphate buffer to obtain a 5 mg/mL suspension. A solution of NADPH was prepared...				US Patent US10221160 (2019) BindingDB Entry DOI: 10.7270/Q2736T6Q
Mycovia Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 3A (Homo sapiens (Human))	BDBM124182 (US10221160, Example 1 \| US8754227, 1) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mycovia Pharmaceuticals, Inc. US Patent					Assay Description Pooled human liver microsome suspension (20 mg/mL) was diluted with phosphate buffer to obtain a 5 mg/mL suspension. A solution of NADPH was prepared...				US Patent US10221160 (2019) BindingDB Entry DOI: 10.7270/Q2736T6Q
Mycovia Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM25817 (2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...) Show SMILES OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank US Patent	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mycovia Pharmaceuticals, Inc. US Patent					Assay Description Pooled human liver microsome suspension (20 mg/mL) was diluted with phosphate buffer to obtain a 5 mg/mL suspension. A solution of NADPH was prepared...				US Patent US10221160 (2019) BindingDB Entry DOI: 10.7270/Q2736T6Q
Mycovia Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM124182 (US10221160, Example 1 \| US8754227, 1) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mycovia Pharmaceuticals, Inc. US Patent					Assay Description Pooled human liver microsome suspension (20 mg/mL) was diluted with phosphate buffer to obtain a 5 mg/mL suspension. A solution of NADPH was prepared...				US Patent US10221160 (2019) BindingDB Entry DOI: 10.7270/Q2736T6Q
Mycovia Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 3A (Homo sapiens (Human))	BDBM124183 (US10221160, Example 2 \| US8754227, 2) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mycovia Pharmaceuticals, Inc. US Patent					Assay Description Pooled human liver microsome suspension (20 mg/mL) was diluted with phosphate buffer to obtain a 5 mg/mL suspension. A solution of NADPH was prepared...				US Patent US10221160 (2019) BindingDB Entry DOI: 10.7270/Q2736T6Q
Mycovia Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM124182 (US10221160, Example 1 \| US8754227, 1) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mycovia Pharmaceuticals, Inc. US Patent					Assay Description Pooled human liver microsome suspension (20 mg/mL) was diluted with phosphate buffer to obtain a 5 mg/mL suspension. A solution of NADPH was prepared...				US Patent US10221160 (2019) BindingDB Entry DOI: 10.7270/Q2736T6Q
Mycovia Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM124183 (US10221160, Example 2 \| US8754227, 2) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mycovia Pharmaceuticals, Inc. US Patent					Assay Description Pooled human liver microsome suspension (20 mg/mL) was diluted with phosphate buffer to obtain a 5 mg/mL suspension. A solution of NADPH was prepared...				US Patent US10221160 (2019) BindingDB Entry DOI: 10.7270/Q2736T6Q
Mycovia Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM124183 (US10221160, Example 2 \| US8754227, 2) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mycovia Pharmaceuticals, Inc. US Patent					Assay Description Pooled human liver microsome suspension (20 mg/mL) was diluted with phosphate buffer to obtain a 5 mg/mL suspension. A solution of NADPH was prepared...				US Patent US10221160 (2019) BindingDB Entry DOI: 10.7270/Q2736T6Q
Mycovia Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%