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Patent code US10221162

Compile Data Set for Download or QSAR

Found 788 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apelin receptor


(Homo sapiens (Human))		BDBM269868
PNG
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OCCO)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C26H31N7O6S/c1-16-11-19(15-27-12-16)25-30-31-26(33(25)22-20(37-4)7-6-8-21(22)38-5)32-40(35,36)18(3)23(39-10-9-34)24-28-13-17(2)14-29-24/h6-8,11-15,18,23,34H,9-10H2,1-5H3,(H,31,32)/t18-,23-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM269870
PNG
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COCCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C27H33N7O6S/c1-17-12-20(16-28-13-17)26-31-32-27(34(26)23-21(38-5)8-7-9-22(23)39-6)33-41(35,36)19(3)24(40-11-10-37-4)25-29-14-18(2)15-30-25/h7-9,12-16,19,24H,10-11H2,1-6H3,(H,32,33)/t19-,24-/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM360102
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)
Show SMILES COCCO[C@H]([C@@H](C)S(=O)(=O)N(C)c1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C28H35N7O6S/c1-18-13-21(17-29-14-18)27-32-33-28(35(27)24-22(39-6)9-8-10-23(24)40-7)34(4)42(36,37)20(3)25(41-12-11-38-5)26-30-15-19(2)16-31-26/h8-10,13-17,20,25H,11-12H2,1-7H3/t20-,25-/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM269916
PNG
((2S,3R)—N-(4-(4,6-dimethoxy-5-pyrimidinyl)-5-...)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C22H24FN9O4S/c1-12-6-15(8-24-7-12)19-29-30-22(32(19)17-20(35-4)27-11-28-21(17)36-5)31-37(33,34)14(3)13(2)18-25-9-16(23)10-26-18/h6-11,13-14H,1-5H3,(H,30,31)/t13-,14-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM269943
PNG
((1R,2R)-1-(2,4-dicyanophenyl)-N-(4-(2,6-dimethoxyp...)
Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1C#N)C#N
Show InChI InChI=1S/C28H27N7O6S/c1-17(26(41-5)20-13-12-18(15-29)14-19(20)16-30)42(36,37)34-28-33-32-27(21-8-6-11-24(31-21)40-4)35(28)25-22(38-2)9-7-10-23(25)39-3/h6-14,17,26H,1-5H3,(H,33,34)/t17-,26+/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM269948
PNG
((2S)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)C[C@@H](O)c2ccc(Cl)cc2S(C)(=O)=O)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C30H38ClN5O8S2Si/c1-42-24-11-9-12-25(43-2)28(24)36-29(22-10-8-13-27(32-22)44-3)33-34-30(36)35(16-17-47(5,6)7)46(40,41)19-23(37)21-15-14-20(31)18-26(21)45(4,38)39/h8-15,18,23,37H,16-17,19H2,1-7H3/t23-/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM360186
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)C[C@@H](O)c2ccc(cc2S(C)(=O)=O)C#N)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C26H26N6O7S2/c1-16-10-18(14-28-13-16)25-29-30-26(32(25)24-21(38-2)6-5-7-22(24)39-3)31-41(36,37)15-20(33)19-9-8-17(12-27)11-23(19)40(4,34)35/h5-11,13-14,20,33H,15H2,1-4H3,(H,30,31)/t20-/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM269995
PNG
((1S,2R)-1-(5-chloro-2-pyridinyl)-N-(4-(2,6-dimetho...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ccc(Cl)cn1
Show InChI InChI=1S/C25H27ClN6O5S/c1-15-11-17(13-27-12-15)24-29-30-25(32(24)22-20(35-3)7-6-8-21(22)36-4)31-38(33,34)16(2)23(37-5)19-10-9-18(26)14-28-19/h6-14,16,23H,1-5H3,(H,30,31)/t16-,23-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM360234
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H29N7O6S/c1-15-13-26-23(27-14-15)22(38-6)16(2)39(33,34)31-25-30-29-24(17-9-7-12-20(28-17)37-5)32(25)21-18(35-3)10-8-11-19(21)36-4/h7-14,16,22H,1-6H3,(H,30,31)/t16-,22-/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270018
PNG
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@@H](O)c2cnc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C24H27N7O5S/c1-14-9-17(12-25-10-14)23-28-29-24(31(23)21-19(35-4)7-6-8-20(21)36-5)30-37(33,34)16(3)22(32)18-13-26-15(2)11-27-18/h6-13,16,22,32H,1-5H3,(H,29,30)/t16-,22-/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270024
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)c2cnc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H27N7O6S/c1-14-12-26-17(13-25-14)22(32)15(2)38(33,34)30-24-29-28-23(16-8-6-11-20(27-16)37-5)31(24)21-18(35-3)9-7-10-19(21)36-4/h6-13,15,22,32H,1-5H3,(H,29,30)/t15-,22-/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270028
PNG
((2R,3S)—N-(4-(2,6-dimethoxyphenyl)-5-(3-pyrid...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@@H](C)c2ncc(C)cn2)nnc1-c1cccnc1
Show InChI InChI=1S/C24H27N7O4S/c1-15-12-26-22(27-13-15)16(2)17(3)36(32,33)30-24-29-28-23(18-8-7-11-25-14-18)31(24)21-19(34-4)9-6-10-20(21)35-5/h6-14,16-17H,1-5H3,(H,29,30)/t16-,17-/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270035
PNG
((1S,2S)-1-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES CO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H24ClN7O5S/c1-14(20(36-4)21-26-12-16(24)13-27-21)37(32,33)30-23-29-28-22(15-7-6-10-25-11-15)31(23)19-17(34-2)8-5-9-18(19)35-3/h5-14,20H,1-4H3,(H,29,30)/t14-,20+/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270040
PNG
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(3-pyrid...)
Show SMILES CCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1cnc(C)cn1
Show InChI InChI=1S/C25H29N7O5S/c1-6-37-23(19-15-27-16(2)13-28-19)17(3)38(33,34)31-25-30-29-24(18-9-8-12-26-14-18)32(25)22-20(35-4)10-7-11-21(22)36-5/h7-15,17,23H,6H2,1-5H3,(H,30,31)/t17-,23-/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270059
PNG
((1R,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1-c1cccnc1
Show InChI InChI=1S/C26H31N7O5S/c1-16(2)38-23(24-28-13-17(3)14-29-24)18(4)39(34,35)32-26-31-30-25(19-9-8-12-27-15-19)33(26)22-20(36-5)10-7-11-21(22)37-6/h7-16,18,23H,1-6H3,(H,31,32)/t18-,23+/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270063
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(2-pyridinyl)...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccn2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C24H27N7O5S/c1-15-13-26-22(27-14-15)21(36-5)16(2)37(32,33)30-24-29-28-23(17-9-6-7-12-25-17)31(24)20-18(34-3)10-8-11-19(20)35-4/h6-14,16,21H,1-5H3,(H,29,30)/t16-,21-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270071
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)
Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncnn1C
Show InChI InChI=1S/C23H28N8O5S/c1-14-10-16(12-24-11-14)21-27-28-23(31(21)19-17(34-4)8-7-9-18(19)35-5)29-37(32,33)15(2)20(36-6)22-25-13-26-30(22)3/h7-13,15,20H,1-6H3,(H,28,29)/t15-,20-/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270072
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-(2-methoxy...)
Show SMILES COCCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H30FN7O6S/c1-16(24-28-14-18(27)15-29-24)17(2)41(35,36)33-26-32-31-25(19-8-6-11-22(30-19)40-13-12-37-3)34(26)23-20(38-4)9-7-10-21(23)39-5/h6-11,14-17H,12-13H2,1-5H3,(H,32,33)/t16-,17-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270073
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-(3,3,3-tri...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)c(n2)[C@@H]2COCCO2)nnc1-c1cccc(OCC(O)(C(F)(F)F)C(F)(F)F)n1
Show InChI InChI=1S/C31H32F7N7O8S/c1-16(26-39-13-18(32)24(41-26)22-14-51-11-12-52-22)17(2)54(47,48)44-28-43-42-27(45(28)25-20(49-3)8-6-9-21(25)50-4)19-7-5-10-23(40-19)53-15-29(46,30(33,34)35)31(36,37)38/h5-10,13,16-17,22,46H,11-12,14-15H2,1-4H3,(H,43,44)/t16-,17-,22-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270100
PNG
((1R,2S,P)—N-(4-(2-(difluoromethoxy)-6-methoxy...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC(F)F)c1ncc(C)cn1
Show InChI InChI=1S/C25H27F2N7O6S/c1-14-12-28-22(29-13-14)21(39-5)15(2)41(35,36)33-25-32-31-23(16-8-6-11-19(30-16)38-4)34(25)20-17(37-3)9-7-10-18(20)40-24(26)27/h6-13,15,21,24H,1-5H3,(H,32,33)/t15-,21-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270104
PNG
((1R,2S)-N-(4-(2,6-bis(difluoromethoxy)phenyl)-5-(5...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC(F)F)cccc1OC(F)F)c1ncc(C)cn1
Show InChI InChI=1S/C25H25F4N7O5S/c1-13-8-16(12-30-9-13)22-33-34-25(35-42(37,38)15(3)20(39-4)21-31-10-14(2)11-32-21)36(22)19-17(40-23(26)27)6-5-7-18(19)41-24(28)29/h5-12,15,20,23-24H,1-4H3,(H,34,35)/t15-,20-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270110
PNG
(N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridiny...)
Show SMILES Fc1cnc(CCS(Cl)(=O)=O)nc1
Show InChI InChI=1S/C6H6ClFN2O2S/c7-13(11,12)2-1-6-9-3-5(8)4-10-6/h3-4H,1-2H2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270116
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)
Show SMILES COc1cnc(nc1)[C@@H](C)[C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H29N7O5S/c1-15-10-18(12-26-11-15)24-29-30-25(32(24)22-20(36-5)8-7-9-21(22)37-6)31-38(33,34)17(3)16(2)23-27-13-19(35-4)14-28-23/h7-14,16-17H,1-6H3,(H,30,31)/t16-,17-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270128
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)[C@@H](C)[C@H](O[Si](C)(C)C(C)(C)C)c2ncc(C)cn2)cc1
Show InChI InChI=1S/C30H43N3O5SSi/c1-22-18-31-29(32-19-22)28(38-40(8,9)30(3,4)5)23(2)39(34,35)33(20-24-10-14-26(36-6)15-11-24)21-25-12-16-27(37-7)17-13-25/h10-19,23,28H,20-21H2,1-9H3/t23-,28-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270114
PNG
((2R,3S)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C24H26ClN7O4S/c1-14-9-17(11-26-10-14)23-29-30-24(32(23)21-19(35-4)7-6-8-20(21)36-5)31-37(33,34)16(3)15(2)22-27-12-18(25)13-28-22/h6-13,15-16H,1-5H3,(H,30,31)/t15-,16-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270137
PNG
((2R,3R)—N-(4-(2,6-dimethoxyphenyl)-5-(3-pyrid...)
Show SMILES COc1cnc(cn1)[C@H](C)[C@@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H27N7O5S/c1-15(18-13-27-21(36-5)14-26-18)16(2)37(32,33)30-24-29-28-23(17-8-7-11-25-12-17)31(24)22-19(34-3)9-6-10-20(22)35-4/h6-16H,1-5H3,(H,29,30)/t15-,16-/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270158
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)C1CC(C)(C)C1
Show InChI InChI=1S/C26H35N5O5S/c1-16-11-18(15-27-14-16)24-28-29-25(31(24)22-20(34-5)9-8-10-21(22)35-6)30-37(32,33)17(2)23(36-7)19-12-26(3,4)13-19/h8-11,14-15,17,19,23H,12-13H2,1-7H3,(H,29,30)/t17-,23-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270161
PNG
((R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyr...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)C[C@@H](O)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C23H25N7O5S/c1-14-8-16(12-24-9-14)22-27-28-23(30(22)20-18(34-3)6-5-7-19(20)35-4)29-36(32,33)13-17(31)21-25-10-15(2)11-26-21/h5-12,17,31H,13H2,1-4H3,(H,28,29)/t17-/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM360405
PNG
((1R,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)
Show SMILES COc1cnc(cn1)[C@@H](OC(C)C)[C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H33N7O6S/c1-16(2)40-25(20-14-30-23(39-7)15-29-20)18(4)41(35,36)33-27-32-31-26(19-11-17(3)12-28-13-19)34(27)24-21(37-5)9-8-10-22(24)38-6/h8-16,18,25H,1-7H3,(H,32,33)/t18-,25+/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270177
PNG
((1R,2R)-1-(5-chloro-2-pyridinyl)-N-(4-(2,6-dimetho...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OC(C)C)c2ccc(Cl)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C27H31ClN6O5S/c1-16(2)39-25(21-11-10-20(28)15-30-21)18(4)40(35,36)33-27-32-31-26(19-12-17(3)13-29-14-19)34(27)24-22(37-5)8-7-9-23(24)38-6/h7-16,18,25H,1-6H3,(H,32,33)/t18-,25+/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270187
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES CN[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H30N8O4S/c1-15-10-18(14-27-11-15)24-30-31-25(33(24)22-19(36-5)8-7-9-20(22)37-6)32-38(34,35)17(3)21(26-4)23-28-12-16(2)13-29-23/h7-14,17,21,26H,1-6H3,(H,31,32)/t17-,21-/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM360421
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COC1CN(C1)[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270201
PNG
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](O)c2ccc(C)nn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C24H27N7O5S/c1-14-11-17(13-25-12-14)23-28-29-24(31(23)21-19(35-4)7-6-8-20(21)36-5)30-37(33,34)16(3)22(32)18-10-9-15(2)26-27-18/h6-13,16,22,32H,1-5H3,(H,29,30)/t16-,22+/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270206
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(2-pyridinyl)...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1-c1ccccn1
Show InChI InChI=1S/C24H27N7O4S/c1-15-13-27-19(14-26-15)16(2)17(3)36(32,33)30-24-29-28-23(18-9-6-7-12-25-18)31(24)22-20(34-4)10-8-11-21(22)35-5/h6-14,16-17H,1-5H3,(H,29,30)/t16-,17-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270237
PNG
((3R,5S)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H]2C[C@@H](O)CN(C2)c2ncc(F)cn2)nnc1-c1cccnc1
Show InChI InChI=1S/C24H25FN8O5S/c1-37-19-6-3-7-20(38-2)21(19)33-22(15-5-4-8-26-10-15)29-30-24(33)31-39(35,36)18-9-17(34)13-32(14-18)23-27-11-16(25)12-28-23/h3-8,10-12,17-18,34H,9,13-14H2,1-2H3,(H,30,31)/t17-,18+/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270237
PNG
((3R,5S)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H]2C[C@@H](O)CN(C2)c2ncc(F)cn2)nnc1-c1cccnc1
Show InChI InChI=1S/C24H25FN8O5S/c1-37-19-6-3-7-20(38-2)21(19)33-22(15-5-4-8-26-10-15)29-30-24(33)31-39(35,36)18-9-17(34)13-32(14-18)23-27-11-16(25)12-28-23/h3-8,10-12,17-18,34H,9,13-14H2,1-2H3,(H,30,31)/t17-,18+/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM360482
PNG
((3R,5S)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H]2C[C@@H](CN(C2)c2ncc(F)cn2)OC(C)C)nnc1-c1cccnc1
Show InChI InChI=1S/C27H31FN8O5S/c1-17(2)41-20-11-21(16-35(15-20)26-30-13-19(28)14-31-26)42(37,38)34-27-33-32-25(18-7-6-10-29-12-18)36(27)24-22(39-3)8-5-9-23(24)40-4/h5-10,12-14,17,20-21H,11,15-16H2,1-4H3,(H,33,34)/t20-,21+/m0/s1
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n/an/an/an/a 30n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM360486
PNG
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methyl-2-p...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OC(C)C)c2cnc(C)cn2)nnc1-c1cccc(C)n1
Show InChI InChI=1S/C27H33N7O5S/c1-16(2)39-25(21-15-28-18(4)14-29-21)19(5)40(35,36)33-27-32-31-26(20-11-8-10-17(3)30-20)34(27)24-22(37-6)12-9-13-23(24)38-7/h8-16,19,25H,1-7H3,(H,32,33)/t19-,25+/m1/s1
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n/an/an/an/a 0.470n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM360488
PNG
((2S,3R)-N-(4-(2,6-difluorophenyl)-5-(5-methyl-3-py...)
Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(F)cccc1F)c1ncc(C)cn1
Show InChI InChI=1S/C23H23F2N7O2S/c1-13-8-17(12-26-9-13)22-29-30-23(32(22)20-18(24)6-5-7-19(20)25)31-35(33,34)16(4)15(3)21-27-10-14(2)11-28-21/h5-12,15-16H,1-4H3,(H,30,31)/t15-,16-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270261
PNG
((1S,2S)-N-(4-(4,6-dimethoxy-5-pyrimidinyl)-5-(5-me...)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C25H31N9O5S/c1-14(2)39-20(21-27-10-16(4)11-28-21)17(5)40(35,36)33-25-32-31-22(18-8-15(3)9-26-12-18)34(25)19-23(37-6)29-13-30-24(19)38-7/h8-14,17,20H,1-7H3,(H,32,33)/t17-,20+/m0/s1
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n/an/an/an/a 9.5n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM360492
PNG
((3R)-1-(5-chloro-2-pyrimidinyl)-N-(4-(4,6-dimethox...)
Show SMILES NS(=O)(=O)[C@H]1CCCNC1
Show InChI InChI=1S/C5H12N2O2S/c6-10(8,9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H2,6,8,9)/t5-/m0/s1
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n/an/an/an/a 14n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM360493
PNG
((3R)-1-(5-chloro-2-pyrimidinyl)-N-(4-(4,6-dimethox...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H]2CCCN(C2)c2ncc(Cl)cn2)n1-c1c(OC)ncnc1OC
Show InChI InChI=1S/C23H25ClN10O5S/c1-37-17-8-4-7-16(29-17)19-30-31-23(34(19)18-20(38-2)27-13-28-21(18)39-3)32-40(35,36)15-6-5-9-33(12-15)22-25-10-14(24)11-26-22/h4,7-8,10-11,13,15H,5-6,9,12H2,1-3H3,(H,31,32)/t15-/m0/s1
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n/an/an/an/a 0.890n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270266
PNG
(5-(4-(2,6-dimethoxyphenyl)-5-((((1S,2R)-1-methyl-2...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1cncc(c1)C#N
Show InChI InChI=1S/C25H26N8O4S/c1-15-11-28-23(29-12-15)16(2)17(3)38(34,35)32-25-31-30-24(19-9-18(10-26)13-27-14-19)33(25)22-20(36-4)7-6-8-21(22)37-5/h6-9,11-14,16-17H,1-5H3,(H,31,32)/t16-,17-/m0/s1
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n/an/an/an/a 1.07E+3n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM270267
PNG
((2S,3R)-3-(5-chloro-2-pyrimidinyl)-N-(5-(6-methoxy...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1C1CCOCC1
Show InChI InChI=1S/C21H26ClN7O4S/c1-13(19-23-11-15(22)12-24-19)14(2)34(30,31)28-21-27-26-20(17-5-4-6-18(25-17)32-3)29(21)16-7-9-33-10-8-16/h4-6,11-14,16H,7-10H2,1-3H3,(H,27,28)/t13-,14-/m0/s1
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n/an/an/an/a 13n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM269508
PNG
(US10058550, Example 27.0 | US10058550, Example 549...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H29N7O6S/c1-15-13-26-23(27-14-15)22(38-6)16(2)39(33,34)31-25-30-29-24(17-9-7-12-20(28-17)37-5)32(25)21-18(35-3)10-8-11-19(21)36-4/h7-14,16,22H,1-6H3,(H,30,31)/t16-,22-/m0/s1
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n/an/an/an/a 0.190n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM269513
PNG
(N-(4-(2,6-dimethoxyphenyl)-5-(6-methyl-2-pyridinyl...)
Show SMILES CCS(=O)(=O)Nc1nnc(-c2cccc(C)n2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C18H21N5O4S/c1-5-28(24,25)22-18-21-20-17(13-9-6-8-12(2)19-13)23(18)16-14(26-3)10-7-11-15(16)27-4/h6-11H,5H2,1-4H3,(H,21,22)
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n/an/an/an/a 830n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM269528
PNG
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(3-pyrid...)
Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1cnc(C)cn1
Show InChI InChI=1S/C24H27N7O5S/c1-15-12-27-18(14-26-15)22(36-5)16(2)37(32,33)30-24-29-28-23(17-8-7-11-25-13-17)31(24)21-19(34-3)9-6-10-20(21)35-4/h6-14,16,22H,1-5H3,(H,29,30)/t16-,22-/m1/s1
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n/an/an/an/a 1.26n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM359748
PNG
((1R,2S)-N-(4-(3-cyanophenyl)-5-(6-methoxy-2-pyridi...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1cccc(c1)C#N)c1ncc(C)cn1
Show InChI InChI=1S/C24H24N8O4S/c1-15-13-26-22(27-14-15)21(36-4)16(2)37(33,34)31-24-30-29-23(19-9-6-10-20(28-19)35-3)32(24)18-8-5-7-17(11-18)12-25/h5-11,13-14,16,21H,1-4H3,(H,30,31)/t16-,21-/m0/s1
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n/an/an/an/a 31n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM269553
PNG
((1R,2S)-N-(4-(2-chlorophenyl)-5-(6-methoxy-2-pyrid...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1ccccc1Cl)c1ncc(C)cn1
Show InChI InChI=1S/C23H24ClN7O4S/c1-14-12-25-21(26-13-14)20(35-4)15(2)36(32,33)30-23-29-28-22(17-9-7-11-19(27-17)34-3)31(23)18-10-6-5-8-16(18)24/h5-13,15,20H,1-4H3,(H,29,30)/t15-,20-/m0/s1
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n/an/an/an/a 2.10n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))		BDBM269554
PNG
((1R,2S)-N-(4-(2,3-dimethylphenyl)-5-(6-methoxy-2-p...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1cccc(C)c1C)c1ncc(C)cn1
Show InChI InChI=1S/C25H29N7O4S/c1-15-13-26-23(27-14-15)22(36-6)18(4)37(33,34)31-25-30-29-24(19-10-8-12-21(28-19)35-5)32(25)20-11-7-9-16(2)17(20)3/h7-14,18,22H,1-6H3,(H,30,31)/t18-,22-/m0/s1
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n/an/an/an/a 2.60n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 788 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%