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Patent code US10221172

Compile Data Set for Download or QSAR
Found 65 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361346
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3-yl)amino) benzo[...)
Show SMILES FC1(F)CCN(C1)C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C18H14F2N6OS/c19-18(20)5-7-26(9-18)17(27)14-11-4-3-10(8-13(11)28-25-14)22-16-15-12(23-24-16)2-1-6-21-15/h1-4,6,8H,5,7,9H2,(H2,22,23,24)
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UniChem
US Patent
n/an/an/an/a 325n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361363
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo ...)
Show SMILES FC1CCN(CC1)C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H17FN6OS/c20-11-5-8-26(9-6-11)19(27)16-13-4-3-12(10-15(13)28-25-16)22-18-17-14(23-24-18)2-1-7-21-17/h1-4,7,10-11H,5-6,8-9H2,(H2,22,23,24)
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UniChem
US Patent
n/an/an/an/a 249n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361365
PNG
(3-neopentyl-N- (1H-pyrazolo[3,4- b]pyridin-3-yl)be...)
Show SMILES CC(C)(C)Cc1nsc2cc(Nc3n[nH]c4ncccc34)ccc12
Show InChI InChI=1S/C18H19N5S/c1-18(2,3)10-14-12-7-6-11(9-15(12)24-23-14)20-17-13-5-4-8-19-16(13)21-22-17/h4-9H,10H2,1-3H3,(H2,19,20,21,22)
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UniChem
US Patent
n/an/an/an/a 884n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361366
PNG
(3-propyl-N-(1H-pyrazolo [4,3-b]pyridin-3- yl)benzo...)
Show SMILES CCCc1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C16H15N5S/c1-2-4-12-11-7-6-10(9-14(11)22-21-12)18-16-15-13(19-20-16)5-3-8-17-15/h3,5-9H,2,4H2,1H3,(H2,18,19,20)
UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/an/an/a 56n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361368
PNG
(3-(tert-butyl)-N-(1H- pyrazolo[4,3-b]pyridin- 3-yl...)
Show SMILES CCCc1nsc2cc(Nc3n[nH]c4ncccc34)ccc12
Show InChI InChI=1S/C16H15N5S/c1-2-4-13-11-7-6-10(9-14(11)22-21-13)18-16-12-5-3-8-17-15(12)19-20-16/h3,5-9H,2,4H2,1H3,(H2,17,18,19,20)
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UniChem
US Patent
n/an/an/an/a 329n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361372
PNG
(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-3- (trifluorom...)
Show SMILES FC(F)(F)c1nsc2cc(Nc3n[nH]c4ncccc34)ccc12
Show InChI InChI=1S/C14H8F3N5S/c15-14(16,17)11-8-4-3-7(6-10(8)23-22-11)19-13-9-2-1-5-18-12(9)20-21-13/h1-6H,(H2,18,19,20,21)
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UniChem
US Patent
n/an/an/an/a 1.24E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361379
PNG
(3-cyclopropyl-N- (1H-pyrazolo [3,4-b]pyrazin-3-yl)...)
Show SMILES C1CC1c1nsc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C15H12N6S/c1-2-8(1)12-10-4-3-9(7-11(10)22-21-12)18-15-13-14(19-20-15)17-6-5-16-13/h3-8H,1-2H2,(H2,17,18,19,20)
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US Patent
n/an/an/an/a 61.1n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361392
PNG
(3-((4,4-difluoropiperidin- 1-yl)methyl)-N- (1H-pyr...)
Show SMILES FC1(F)CCN(Cc2nsc3cc(Nc4n[nH]c5cccnc45)cnc23)CC1
Show InChI InChI=1S/C18H17F2N7S/c19-18(20)3-6-27(7-4-18)10-13-15-14(28-26-13)8-11(9-22-15)23-17-16-12(24-25-17)2-1-5-21-16/h1-2,5,8-9H,3-4,6-7,10H2,(H2,23,24,25)
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UniChem
US Patent
n/an/an/an/a 81.1n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361404
PNG
(3-((3,3-difluoropiperidin- 1-yl)methyl)-N-(1H- pyr...)
Show SMILES FC1(F)CCCN(Cc2nsc3cc(Nc4n[nH]c5ncccc45)cnc23)C1
Show InChI InChI=1S/C18H17F2N7S/c19-18(20)4-2-6-27(10-18)9-13-15-14(28-26-13)7-11(8-22-15)23-17-12-3-1-5-21-16(12)24-25-17/h1,3,5,7-8H,2,4,6,9-10H2,(H2,21,23,24,25)
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n/an/an/an/a 101n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361405
PNG
(1-(4-(6-((1H-pyrazolo [3,4-b]pyrazin-3-yl) amino)b...)
Show SMILES CC(=O)N1CCC(CC1)c1nsc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C19H19N7OS/c1-11(27)26-8-4-12(5-9-26)16-14-3-2-13(10-15(14)28-25-16)22-19-17-18(23-24-19)21-7-6-20-17/h2-3,6-7,10,12H,4-5,8-9H2,1H3,(H2,21,22,23,24)
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UniChem
US Patent
n/an/an/an/a 154n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361407
PNG
((4-(6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)ben...)
Show SMILES O=C(C1CC1)N1CCC(CC1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C22H22N6OS/c29-22(14-3-4-14)28-10-7-13(8-11-28)19-16-6-5-15(12-18(16)30-27-19)24-21-20-17(25-26-21)2-1-9-23-20/h1-2,5-6,9,12-14H,3-4,7-8,10-11H2,(H2,24,25,26)
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UniChem
US Patent
n/an/an/an/a 388n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361350
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Show SMILES CC1CN(CC(C)O1)C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C20H20N6O2S/c1-11-9-26(10-12(2)28-11)20(27)17-14-6-5-13(8-16(14)29-25-17)22-19-18-15(23-24-19)4-3-7-21-18/h3-8,11-12H,9-10H2,1-2H3,(H2,22,23,24)
UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/an/a 306n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361357
PNG
((6-((1H-pyrazolo[4,3-b] pyridin-3-yl)amino) benzo[...)
Show SMILES O=C(N1CCC(C1)N1CCOCC1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C22H23N7O2S/c30-22(29-7-5-15(13-29)28-8-10-31-11-9-28)19-16-4-3-14(12-18(16)32-27-19)24-21-20-17(25-26-21)2-1-6-23-20/h1-4,6,12,15H,5,7-11,13H2,(H2,24,25,26)
UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/an/a 3.45E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361364
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Show SMILES FC(F)(F)C1CCN(CC1)C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C20H17F3N6OS/c21-20(22,23)11-5-8-29(9-6-11)19(30)16-13-4-3-12(10-15(13)31-28-16)25-18-17-14(26-27-18)2-1-7-24-17/h1-4,7,10-11H,5-6,8-9H2,(H2,25,26,27)
UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/an/a 50n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361368
PNG
(3-(tert-butyl)-N-(1H- pyrazolo[4,3-b]pyridin- 3-yl...)
Show SMILES CCCc1nsc2cc(Nc3n[nH]c4ncccc34)ccc12
Show InChI InChI=1S/C16H15N5S/c1-2-4-13-11-7-6-10(9-14(11)22-21-13)18-16-12-5-3-8-17-15(12)19-20-16/h3,5-9H,2,4H2,1H3,(H2,17,18,19,20)
UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/an/a 220n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361377
PNG
(1-(4-(6-((1H- pyrazolo[4,3-b] pyridin-3-yl)amino) ...)
Show SMILES CC(=O)N1CCC(CC1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C20H20N6OS/c1-12(27)26-9-6-13(7-10-26)18-15-5-4-14(11-17(15)28-25-18)22-20-19-16(23-24-20)3-2-8-21-19/h2-5,8,11,13H,6-7,9-10H2,1H3,(H2,22,23,24)
UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/an/an/a 199n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361383
PNG
(3-ethyl-N-(1H- pyrazolo[4,3-b] pyridin-3- yl)isoth...)
Show SMILES CCc1nsc2cc(Nc3n[nH]c4cccnc34)cnc12
Show InChI InChI=1S/C14H12N6S/c1-2-9-12-11(21-20-9)6-8(7-16-12)17-14-13-10(18-19-14)4-3-5-15-13/h3-7H,2H2,1H3,(H2,17,18,19)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 38.3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361387
PNG
(N-(1H-pyrazolo[4,3-b] pyiridn-3-yl)-3- (thiophen-3...)
Show SMILES N(c1n[nH]c2cccnc12)c1ccc2c(nsc2c1)-c1ccsc1
Show InChI InChI=1S/C17H11N5S2/c1-2-13-16(18-6-1)17(21-20-13)19-11-3-4-12-14(8-11)24-22-15(12)10-5-7-23-9-10/h1-9H,(H2,19,20,21)
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 216n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361389
PNG
((6-((1H-pyrazolo[4,3-b] pyridin-3-yl)amino) isothi...)
Show SMILES OCc1nsc2cc(Nc3n[nH]c4cccnc34)cnc12
Show InChI InChI=1S/C13H10N6OS/c20-6-9-11-10(21-19-9)4-7(5-15-11)16-13-12-8(17-18-13)2-1-3-14-12/h1-5,20H,6H2,(H2,16,17,18)
UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/an/a 1.07E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361397
PNG
(3-(morpholinomethyl)- N-(1H- pyrazolo[3,4-b]pyridi...)
Show SMILES C(N1CCOCC1)c1nsc2cc(Nc3n[nH]c4ncccc34)cnc12
Show InChI InChI=1S/C17H17N7OS/c1-2-12-16(18-3-1)21-22-17(12)20-11-8-14-15(19-9-11)13(23-26-14)10-24-4-6-25-7-5-24/h1-3,8-9H,4-7,10H2,(H2,18,20,21,22)
UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/an/a 1.03E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361399
PNG
(3-((4-(tert-butyl)piperidin- 1-yl)methyl)-N-(1H- p...)
Show SMILES CC(C)(C)C1CCN(Cc2nsc3cc(Nc4n[nH]c5ncccc45)cnc23)CC1
Show InChI InChI=1S/C22H27N7S/c1-22(2,3)14-6-9-29(10-7-14)13-17-19-18(30-28-17)11-15(12-24-19)25-21-16-5-4-8-23-20(16)26-27-21/h4-5,8,11-12,14H,6-7,9-10,13H2,1-3H3,(H2,23,25,26,27)
UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/an/a 4.13E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361406
PNG
(1-(4-(6-((1H- pyrazolo[3,4-b] pyridin-3-yl) amino)...)
Show SMILES CC(=O)N1CCC(CC1)c1nsc2cc(Nc3n[nH]c4ncccc34)ccc12
Show InChI InChI=1S/C20H20N6OS/c1-12(27)26-9-6-13(7-10-26)18-15-5-4-14(11-17(15)28-25-18)22-20-16-3-2-8-21-19(16)23-24-20/h2-5,8,11,13H,6-7,9-10H2,1H3,(H2,21,22,23,24)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 409n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361370
PNG
(3-neopentyl-N-(1H- pyrazolo[3,4- b]pyrazin-3-yl) i...)
Show SMILES CC(C)(C)Cc1nsc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C17H18N6S/c1-17(2,3)9-12-11-5-4-10(8-13(11)24-23-12)20-16-14-15(21-22-16)19-7-6-18-14/h4-8H,9H2,1-3H3,(H2,19,20,21,22)
UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/an/an/a 99.5n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361375
PNG
(4-(6-((1H-pyrazolo[3,4-b] pyrazin-3-yl)amino)benzo...)
Show SMILES CN1CCN(CC1=O)C(=O)c1nsc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C18H16N8O2S/c1-25-6-7-26(9-13(25)27)18(28)14-11-3-2-10(8-12(11)29-24-14)21-17-15-16(22-23-17)20-5-4-19-15/h2-5,8H,6-7,9H2,1H3,(H2,20,21,22,23)
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n/an/an/an/a 1.53E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361376
PNG
((6-((1H-pyrazolo[3,4-b] pyrazin-3- yl)amino)benzo[...)
Show SMILES FC1(F)CCN(CC1)C(=O)c1nsc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C18H15F2N7OS/c19-18(20)3-7-27(8-4-18)17(28)13-11-2-1-10(9-12(11)29-26-13)23-16-14-15(24-25-16)22-6-5-21-14/h1-2,5-6,9H,3-4,7-8H2,(H2,22,23,24,25)
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n/an/an/an/a 827n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361382
PNG
(3-(sec-butyl)-N-(1H- pyrazolo[4,3-b]pyridin- 3-yl)...)
Show SMILES CCC(C)c1nsc2cc(Nc3n[nH]c4cccnc34)cnc12
Show InChI InChI=1S/C16H16N6S/c1-3-9(2)13-15-12(23-22-13)7-10(8-18-15)19-16-14-11(20-21-16)5-4-6-17-14/h4-9H,3H2,1-2H3,(H2,19,20,21)
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n/an/an/an/a 54.2n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361385
PNG
(3-phenyl-N-(1H-pyrazolo [4,3-b]pyridin-3- yl)benzo...)
Show SMILES N(c1n[nH]c2cccnc12)c1ccc2c(nsc2c1)-c1ccccc1
Show InChI InChI=1S/C19H13N5S/c1-2-5-12(6-3-1)17-14-9-8-13(11-16(14)25-24-17)21-19-18-15(22-23-19)7-4-10-20-18/h1-11H,(H2,21,22,23)
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n/an/an/an/a 226n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361386
PNG
(3-phenyl-N-(1H-pyrazolo [3,4-b]pyridin-3- yl)benzo...)
Show SMILES N(c1n[nH]c2ncccc12)c1ccc2c(nsc2c1)-c1ccccc1
Show InChI InChI=1S/C19H13N5S/c1-2-5-12(6-3-1)17-14-9-8-13(11-16(14)25-24-17)21-19-15-7-4-10-20-18(15)22-23-19/h1-11H,(H2,20,21,22,23)
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n/an/an/an/a 2.04E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361388
PNG
(N-(1H-pyrazolo[3,4-b] pyrazin-3-yl)-3- (thiophen-3...)
Show SMILES N(c1n[nH]c2nccnc12)c1ccc2c(nsc2c1)-c1ccsc1
Show InChI InChI=1S/C16H10N6S2/c1-2-11-12(24-22-13(11)9-3-6-23-8-9)7-10(1)19-16-14-15(20-21-16)18-5-4-17-14/h1-8H,(H2,18,19,20,21)
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n/an/an/an/a 144n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361345
PNG
(3-neopentyl-N- (1H-pyrazolo[4,3- b]pyridin-3-yl)be...)
Show SMILES CC(C)(C)Cc1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C18H19N5S/c1-18(2,3)10-14-12-7-6-11(9-15(12)24-23-14)20-17-16-13(21-22-17)5-4-8-19-16/h4-9H,10H2,1-3H3,(H2,20,21,22)
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n/an/an/an/a 284n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361348
PNG
((6-((1H-pyrazolo[4,3-b] pyridin-3-yl)amino) benzo[...)
Show SMILES FC1(F)CCN(CC1)C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H16F2N6OS/c20-19(21)5-8-27(9-6-19)18(28)15-12-4-3-11(10-14(12)29-26-15)23-17-16-13(24-25-17)2-1-7-22-16/h1-4,7,10H,5-6,8-9H2,(H2,23,24,25)
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n/an/an/an/a 60n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361352
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Show SMILES FC1(F)CCCN(C1)C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H16F2N6OS/c20-19(21)6-2-8-27(10-19)18(28)15-12-5-4-11(9-14(12)29-26-15)23-17-16-13(24-25-17)3-1-7-22-16/h1,3-5,7,9H,2,6,8,10H2,(H2,23,24,25)
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n/an/an/an/a 233n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361353
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Show SMILES O=C(N1CCCC1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C18H16N6OS/c25-18(24-8-1-2-9-24)15-12-6-5-11(10-14(12)26-23-15)20-17-16-13(21-22-17)4-3-7-19-16/h3-7,10H,1-2,8-9H2,(H2,20,21,22)
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n/an/an/an/a 1.34E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361359
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Show SMILES O=C(N1CCSCC1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C18H16N6OS2/c25-18(24-6-8-26-9-7-24)15-12-4-3-11(10-14(12)27-23-15)20-17-16-13(21-22-17)2-1-5-19-16/h1-5,10H,6-9H2,(H2,20,21,22)
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n/an/an/an/a 85n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361360
PNG
((6-((1H-pyrazolo[4,3-b] pyridin-3-yl) amino)benzo[...)
Show SMILES O=C(N1CCCOCC1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H18N6O2S/c26-19(25-7-2-9-27-10-8-25)16-13-5-4-12(11-15(13)28-24-16)21-18-17-14(22-23-18)3-1-6-20-17/h1,3-6,11H,2,7-10H2,(H2,21,22,23)
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n/an/an/an/a 607n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361362
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Show SMILES CC1CCN(CC1)C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C20H20N6OS/c1-12-6-9-26(10-7-12)20(27)17-14-5-4-13(11-16(14)28-25-17)22-19-18-15(23-24-19)3-2-8-21-18/h2-5,8,11-12H,6-7,9-10H2,1H3,(H2,22,23,24)
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n/an/an/an/a 408n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361384
PNG
(3-ethyl-N-(1H- pyrazolo[3,4-b] pyridin-3-yl)isothi...)
Show SMILES CCc1nsc2cc(Nc3n[nH]c4ncccc34)cnc12
Show InChI InChI=1S/C14H12N6S/c1-2-10-12-11(21-20-10)6-8(7-16-12)17-14-9-4-3-5-15-13(9)18-19-14/h3-7H,2H2,1H3,(H2,15,17,18,19)
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n/an/an/an/a 100n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361393
PNG
(3-((4-fluoropiperidin- 1-yl)methyl)-N-(1H- pyrazol...)
Show SMILES FC1CCN(Cc2nsc3cc(Nc4n[nH]c5cccnc45)cnc23)CC1
Show InChI InChI=1S/C18H18FN7S/c19-11-3-6-26(7-4-11)10-14-16-15(27-25-14)8-12(9-21-16)22-18-17-13(23-24-18)2-1-5-20-17/h1-2,5,8-9,11H,3-4,6-7,10H2,(H2,22,23,24)
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n/an/an/an/a 247n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361396
PNG
(3-(morpholinomethyl)- N-(1H- pyrazolo[4,3-b]pyridi...)
Show SMILES C(N1CCOCC1)c1nsc2cc(Nc3n[nH]c4cccnc34)cnc12
Show InChI InChI=1S/C17H17N7OS/c1-2-12-16(18-3-1)17(22-21-12)20-11-8-14-15(19-9-11)13(23-26-14)10-24-4-6-25-7-5-24/h1-3,8-9H,4-7,10H2,(H2,20,21,22)
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n/an/an/an/a 630n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361401
PNG
((S)-3-((2- methylmorpholino) methyl)-N-(1H- pyrazo...)
Show SMILES C[C@H]1CN(Cc2nsc3cc(Nc4n[nH]c5cccnc45)cnc23)CCO1
Show InChI InChI=1S/C18H19N7OS/c1-11-9-25(5-6-26-11)10-14-16-15(27-24-14)7-12(8-20-16)21-18-17-13(22-23-18)3-2-4-19-17/h2-4,7-8,11H,5-6,9-10H2,1H3,(H2,21,22,23)/t11-/m0/s1
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n/an/an/an/a 353n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361349
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3-yl) amino)benzo[...)
Show SMILES O=C(N1CCOCC1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C18H16N6O2S/c25-18(24-6-8-26-9-7-24)15-12-4-3-11(10-14(12)27-23-15)20-17-16-13(21-22-17)2-1-5-19-16/h1-5,10H,6-9H2,(H2,20,21,22)
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n/an/an/an/a 303n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361351
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3-yl) amino)benzo[...)
Show SMILES O=C(N1CCS(=O)(=O)CC1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C18H16N6O3S2/c25-18(24-6-8-29(26,27)9-7-24)15-12-4-3-11(10-14(12)28-23-15)20-17-16-13(21-22-17)2-1-5-19-16/h1-5,10H,6-9H2,(H2,20,21,22)
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n/an/an/an/a 136n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361367
PNG
(3-propyl-N-(1H- pyrazolo[3,4-b] pyrazine-3- yl)ben...)
Show SMILES CCCc1nsc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C15H14N6S/c1-2-3-11-10-5-4-9(8-12(10)22-21-11)18-15-13-14(19-20-15)17-7-6-16-13/h4-8H,2-3H2,1H3,(H2,17,18,19,20)
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n/an/an/an/a 23.4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361395
PNG
(3-(((3,3-difluorocyclobutyl) (methyl)amino)methyl)...)
Show SMILES CN(Cc1nsc2cc(Nc3n[nH]c4ncccc34)cnc12)C1CC(F)(F)C1
Show InChI InChI=1S/C18H17F2N7S/c1-27(11-6-18(19,20)7-11)9-13-15-14(28-26-13)5-10(8-22-15)23-17-12-3-2-4-21-16(12)24-25-17/h2-5,8,11H,6-7,9H2,1H3,(H2,21,23,24,25)
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n/an/an/an/a 568n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361344
PNG
(3-methyl-N- (1H-pyrazolo[4,3-b] pyridin-3- yl)benz...)
Show SMILES Cc1nsc2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C14H11N5S/c1-8-10-7-9(4-5-12(10)20-19-8)16-14-13-11(17-18-14)3-2-6-15-13/h2-7H,1H3,(H2,16,17,18)
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n/an/an/an/a 187n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361347
PNG
(6-((1H-pyrazolo[4,3-b] pyridin- 3-yl)amino)-N-(3,3...)
Show SMILES FC1(F)CC(C1)NC(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C18H14F2N6OS/c19-18(20)7-10(8-18)23-17(27)14-11-4-3-9(6-13(11)28-26-14)22-16-15-12(24-25-16)2-1-5-21-15/h1-6,10H,7-8H2,(H,23,27)(H2,22,24,25)
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n/an/an/an/a 32n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361356
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Show SMILES O=C(N1CCN2CCCC2C1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C21H21N7OS/c29-21(28-10-9-27-8-2-3-14(27)12-28)18-15-6-5-13(11-17(15)30-26-18)23-20-19-16(24-25-20)4-1-7-22-19/h1,4-7,11,14H,2-3,8-10,12H2,(H2,23,24,25)
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n/an/an/an/a 1.61E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361358
PNG
(6-((1H-pyrazolo[4,3-b] pyridin-3- yl)amino)-N-(3,3...)
Show SMILES CN(C1CC(F)(F)C1)C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H16F2N6OS/c1-27(11-8-19(20,21)9-11)18(28)15-12-5-4-10(7-14(12)29-26-15)23-17-16-13(24-25-17)3-2-6-22-16/h2-7,11H,8-9H2,1H3,(H2,23,24,25)
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n/an/an/an/a 164n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361391
PNG
(3-(piperidin-1- ylmethyl)-N-(1H- pyrazolo[3,4-b]py...)
Show SMILES C(N1CCCCC1)c1nsc2cc(Nc3n[nH]c4ncccc34)cnc12
Show InChI InChI=1S/C18H19N7S/c1-2-7-25(8-3-1)11-14-16-15(26-24-14)9-12(10-20-16)21-18-13-5-4-6-19-17(13)22-23-18/h4-6,9-10H,1-3,7-8,11H2,(H2,19,21,22,23)
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n/an/an/an/a 1.56E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361400
PNG
(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-3- (pyrrolidin...)
Show SMILES C(N1CCCC1)c1nsc2cc(Nc3n[nH]c4cccnc34)cnc12
Show InChI InChI=1S/C17H17N7S/c1-2-7-24(6-1)10-13-15-14(25-23-13)8-11(9-19-15)20-17-16-12(21-22-17)4-3-5-18-16/h3-5,8-9H,1-2,6-7,10H2,(H2,20,21,22)
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US Patent
n/an/an/an/a 3.74E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361408
PNG
((4-(6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)ben...)
Show SMILES O=C(C1CCOCC1)N1CCC(CC1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C24H26N6O2S/c31-24(16-7-12-32-13-8-16)30-10-5-15(6-11-30)21-18-4-3-17(14-20(18)33-29-21)26-23-22-19(27-28-23)2-1-9-25-22/h1-4,9,14-16H,5-8,10-13H2,(H2,26,27,28)
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US Patent
n/an/an/an/a 1.20E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361361
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Show SMILES CC1CC(C)CN(C1)C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C21H22N6OS/c1-12-8-13(2)11-27(10-12)21(28)18-15-6-5-14(9-17(15)29-26-18)23-20-19-16(24-25-20)4-3-7-22-19/h3-7,9,12-13H,8,10-11H2,1-2H3,(H2,23,24,25)
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n/an/an/an/a 517n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361371
PNG
(3-neopentyl-N-(1H- pyrazolo[3,4- b]pyridin-3-yl) i...)
Show SMILES CC(C)(C)Cc1nsc2cc(Nc3n[nH]c4ncccc34)cnc12
Show InChI InChI=1S/C17H18N6S/c1-17(2,3)8-12-14-13(24-23-12)7-10(9-19-14)20-16-11-5-4-6-18-15(11)21-22-16/h4-7,9H,8H2,1-3H3,(H2,18,20,21,22)
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n/an/an/an/a 119n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361374
PNG
(8-(6-((1H-pyrazolo[3,4-b] pyrazin-3-yl)amino) benz...)
Show SMILES CN1CCC2(CCN(CC2)C(=O)c2nsc3cc(Nc4n[nH]c5nccnc45)ccc23)C1=O
Show InChI InChI=1S/C22H22N8O2S/c1-29-9-4-22(21(29)32)5-10-30(11-6-22)20(31)16-14-3-2-13(12-15(14)33-28-16)25-19-17-18(26-27-19)24-8-7-23-17/h2-3,7-8,12H,4-6,9-11H2,1H3,(H2,24,25,26,27)
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n/an/an/an/a 1.21E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361380
PNG
(2-(6-((1H-pyrazolo [4,3-b]pyridin- 3-yl)amino)benz...)
Show SMILES CC(C)(O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C16H15N5OS/c1-16(2,22)14-10-6-5-9(8-12(10)23-21-14)18-15-13-11(19-20-15)4-3-7-17-13/h3-8,22H,1-2H3,(H2,18,19,20)
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n/an/an/an/a 1.03E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361381
PNG
(3-methyl-N-(1H-pyrazolo [4,3-b]pyridin-3- yl)isoth...)
Show SMILES Cc1nsc2cc(Nc3n[nH]c4cccnc34)cnc12
Show InChI InChI=1S/C13H10N6S/c1-7-11-10(20-19-7)5-8(6-15-11)16-13-12-9(17-18-13)3-2-4-14-12/h2-6H,1H3,(H2,16,17,18)
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n/an/an/an/a 157n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361390
PNG
(3-methyl-N-(1H-pyrazolo [3,4-b]pyridin-3- yl)isoth...)
Show SMILES Cc1nsc2cc(Nc3n[nH]c4ncccc34)cnc12
Show InChI InChI=1S/C13H10N6S/c1-7-11-10(20-19-7)5-8(6-15-11)16-13-9-3-2-4-14-12(9)17-18-13/h2-6H,1H3,(H2,14,16,17,18)
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n/an/an/an/a 180n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361398
PNG
(3-((4-(tert-butyl)piperidin- 1-yl)methyl)-N-(1H- p...)
Show SMILES CC(C)(C)C1CCN(Cc2nsc3cc(Nc4n[nH]c5cccnc45)cnc23)CC1
Show InChI InChI=1S/C22H27N7S/c1-22(2,3)14-6-9-29(10-7-14)13-17-19-18(30-28-17)11-15(12-24-19)25-21-20-16(26-27-21)5-4-8-23-20/h4-5,8,11-12,14H,6-7,9-10,13H2,1-3H3,(H2,25,26,27)
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n/an/an/an/a 1.39E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361403
PNG
(3-((3,3-difluoropiperidin- 1-yl)methyl)-N-(1H- pyr...)
Show SMILES FC1(F)CCCN(Cc2nsc3cc(Nc4n[nH]c5cccnc45)cnc23)C1
Show InChI InChI=1S/C18H17F2N7S/c19-18(20)4-2-6-27(10-18)9-13-15-14(28-26-13)7-11(8-22-15)23-17-16-12(24-25-17)3-1-5-21-16/h1,3,5,7-8H,2,4,6,9-10H2,(H2,23,24,25)
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n/an/an/an/a 55.9n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361354
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Show SMILES O=C(N1CCCC1c1ccccn1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C23H19N7OS/c31-23(30-12-4-7-18(30)16-5-1-2-10-24-16)20-15-9-8-14(13-19(15)32-29-20)26-22-21-17(27-28-22)6-3-11-25-21/h1-3,5-6,8-11,13,18H,4,7,12H2,(H2,26,27,28)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361355
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Show SMILES CN1CCN(CC1)C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H19N7OS/c1-25-7-9-26(10-8-25)19(27)16-13-5-4-12(11-15(13)28-24-16)21-18-17-14(22-23-18)3-2-6-20-17/h2-6,11H,7-10H2,1H3,(H2,21,22,23)
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n/an/an/an/a 1.14E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361373
PNG
(6-((1H-pyrazolo[3,4-b] pyrazin-3- yl)amino)-N-(3,3...)
Show SMILES FC1(F)CC(C1)NC(=O)c1nsc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C17H13F2N7OS/c18-17(19)6-9(7-17)23-16(27)12-10-2-1-8(5-11(10)28-26-12)22-15-13-14(24-25-15)21-4-3-20-13/h1-5,9H,6-7H2,(H,23,27)(H2,21,22,24,25)
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n/an/an/an/a 42.6n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361378
PNG
(3-cyclopropyl-N- (1H-pyrazolo [4,3-b]pyridin-3-yl)...)
Show SMILES C1CC1c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C16H13N5S/c1-2-12-15(17-7-1)16(20-19-12)18-10-5-6-11-13(8-10)22-21-14(11)9-3-4-9/h1-2,5-9H,3-4H2,(H2,18,19,20)
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n/an/an/an/a 78.2n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361394
PNG
(3-(((3,3-difluoro- cyclobutyl) (methyl)amino)methy...)
Show SMILES CN(Cc1nsc2cc(Nc3n[nH]c4cccnc34)cnc12)C1CC(F)(F)C1
Show InChI InChI=1S/C18H17F2N7S/c1-27(11-6-18(19,20)7-11)9-13-15-14(28-26-13)5-10(8-22-15)23-17-16-12(24-25-17)3-2-4-21-16/h2-5,8,11H,6-7,9H2,1H3,(H2,23,24,25)
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n/an/an/an/a 334n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361402
PNG
(3-((2,2- dimethylmorpholino) methyl)-N- (1H-pyrazo...)
Show SMILES CC1(C)CN(Cc2nsc3cc(Nc4n[nH]c5cccnc45)cnc23)CCO1
Show InChI InChI=1S/C19H21N7OS/c1-19(2)11-26(6-7-27-19)10-14-16-15(28-25-14)8-12(9-21-16)22-18-17-13(23-24-18)4-3-5-20-17/h3-5,8-9H,6-7,10-11H2,1-2H3,(H2,22,23,24)
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n/an/an/an/a 147n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%