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Patent code US10221175

Compile Data Set for Download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361623
PNG
(US10221175, Compound 28)
Show SMILES Cn1cc(cn1)-c1cc(F)c(CN2Cc3ccc4nccn4c3C2=O)c(F)c1
Show InChI InChI=1S/C20H15F2N5O/c1-25-9-14(8-24-25)13-6-16(21)15(17(22)7-13)11-26-10-12-2-3-18-23-4-5-27(18)19(12)20(26)28/h2-9H,10-11H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.37E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361633
PNG
(US10221175, Compound 38)
Show SMILES O=C1N(Cc2ccc(nc2)N2CCOCC2)Cc2ccc3nccn3c12
Show InChI InChI=1S/C19H19N5O2/c25-19-18-15(2-4-17-20-5-6-24(17)18)13-23(19)12-14-1-3-16(21-11-14)22-7-9-26-10-8-22/h1-6,11H,7-10,12-13H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361626
PNG
(US10221175, Compound 31)
Show SMILES Cn1cc(cn1)-c1cc(F)c(CN2Cc3ccc4ncnn4c3C2=O)c(F)c1
Show InChI InChI=1S/C19H14F2N6O/c1-25-7-13(6-23-25)12-4-15(20)14(16(21)5-12)9-26-8-11-2-3-17-22-10-24-27(17)18(11)19(26)28/h2-7,10H,8-9H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.63E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361631
PNG
(US10221175, Compound 36)
Show SMILES Cc1ccc(CN2Cc3ccc4nccn4c3C2=O)cn1
Show InChI InChI=1S/C16H14N4O/c1-11-2-3-12(8-18-11)9-19-10-13-4-5-14-17-6-7-20(14)15(13)16(19)21/h2-8H,9-10H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361632
PNG
(US10221175, Compound 37)
Show SMILES O=C1N(Cc2ccc(nc2)-n2ccnn2)Cc2ccc3nccn3c12
Show InChI InChI=1S/C17H13N7O/c25-17-16-13(2-4-14-18-5-7-23(14)16)11-22(17)10-12-1-3-15(19-9-12)24-8-6-20-21-24/h1-9H,10-11H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361598
PNG
(US10221175, Compound 3)
Show SMILES Cn1cc(cn1)-c1cc(F)c(CN2Cc3ccc4nncn4c3C2=O)c(F)c1
Show InChI InChI=1S/C19H14F2N6O/c1-25-7-13(6-23-25)12-4-15(20)14(16(21)5-12)9-26-8-11-2-3-17-24-22-10-27(17)18(11)19(26)28/h2-7,10H,8-9H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 656n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361603
PNG
(US10221175, Compound 8)
Show SMILES Cc1ccc(-c2ccc(CN3Cc4ccc5nncn5c4C3=O)c(F)c2)c2cn(C)nc12
Show InChI InChI=1S/C24H19FN6O/c1-14-3-7-18(19-12-29(2)28-22(14)19)15-4-5-16(20(25)9-15)10-30-11-17-6-8-21-27-26-13-31(21)23(17)24(30)32/h3-9,12-13H,10-11H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.06E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361605
PNG
(US10221175, Compound 10)
Show SMILES Fc1cc(ccc1CN1Cc2ccc3nncn3c2C1=O)-c1ccc2ncccc2c1
Show InChI InChI=1S/C24H16FN5O/c25-20-11-16(15-5-7-21-17(10-15)2-1-9-26-21)3-4-18(20)12-29-13-19-6-8-22-28-27-14-30(22)23(19)24(29)31/h1-11,14H,12-13H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.57E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361620
PNG
(US10221175, Compound 25)
Show SMILES Fc1ccc(cc1CN1Cc2ccc3nncn3c2C1=O)-c1ccc2ncccc2c1
Show InChI InChI=1S/C24H16FN5O/c25-20-6-3-15(16-4-7-21-17(10-16)2-1-9-26-21)11-19(20)13-29-12-18-5-8-22-28-27-14-30(22)23(18)24(29)31/h1-11,14H,12-13H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361621
PNG
(US10221175, Compound 26)
Show SMILES COc1ccc(cn1)-c1ccc(F)c(CN2Cc3ccc4nncn4c3C2=O)c1
Show InChI InChI=1S/C21H16FN5O2/c1-29-19-7-4-14(9-23-19)13-2-5-17(22)16(8-13)11-26-10-15-3-6-18-25-24-12-27(18)20(15)21(26)28/h2-9,12H,10-11H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361627
PNG
(US10221175, Compound 32)
Show SMILES Cn1cc2c(cccc2n1)-c1cc(F)c(CN2Cc3ccc4nccn4c3C2=O)c(F)c1
Show InChI InChI=1S/C24H17F2N5O/c1-29-12-17-16(3-2-4-21(17)28-29)15-9-19(25)18(20(26)10-15)13-30-11-14-5-6-22-27-7-8-31(22)23(14)24(30)32/h2-10,12H,11,13H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.40E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361635
PNG
(US10221175, Compound 40)
Show SMILES Fc1cc(ccc1CN1Cc2ccc3nccn3c2C1=O)-n1cccn1
Show InChI InChI=1S/C19H14FN5O/c20-16-10-15(25-8-1-6-22-25)4-2-13(16)11-23-12-14-3-5-17-21-7-9-24(17)18(14)19(23)26/h1-10H,11-12H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361636
PNG
(US10221175, Compound 41)
Show SMILES CNC(=O)c1ccc(CN2Cc3ccc4nccn4c3C2=O)cc1
Show InChI InChI=1S/C18H16N4O2/c1-19-17(23)13-4-2-12(3-5-13)10-21-11-14-6-7-15-20-8-9-22(15)16(14)18(21)24/h2-9H,10-11H2,1H3,(H,19,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361602
PNG
(US10221175, Compound 7)
Show SMILES COc1ccc(cn1)-c1cc(F)c(CN2Cc3ccc4nncn4c3C2=O)c(F)c1
Show InChI InChI=1S/C21H15F2N5O2/c1-30-19-5-3-12(8-24-19)14-6-16(22)15(17(23)7-14)10-27-9-13-2-4-18-26-25-11-28(18)20(13)21(27)29/h2-8,11H,9-10H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.64E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361610
PNG
(US10221175, Compound 15)
Show SMILES Cc1nnc2ccc3CN(Cc4c(F)cc(cc4F)-c4ccc5nn(C)cc5c4)C(=O)c3n12
Show InChI InChI=1S/C24H18F2N6O/c1-13-27-28-22-6-4-15-11-31(24(33)23(15)32(13)22)12-18-19(25)8-16(9-20(18)26)14-3-5-21-17(7-14)10-30(2)29-21/h3-10H,11-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.24E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361618
PNG
(US10221175, Compound 23)
Show SMILES CN1C=[C]2=C(C=CCC2=N1)c1ccc(F)c(CN2Cc3ccc4nncn4c3C2=O)c1
Show InChI InChI=1S/C23H18FN6O/c1-28-12-18-17(3-2-4-20(18)27-28)14-5-7-19(24)16(9-14)11-29-10-15-6-8-21-26-25-13-30(21)22(15)23(29)31/h2-3,5-9,12-13H,4,10-11H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC sid
UniChem
US Patent
n/an/an/an/a 1.35E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361628
PNG
(US10221175, Compound 33)
Show SMILES Cn1cc2c(cccc2n1)-c1ccc(CN2Cc3ccc4nccn4c3C2=O)c(F)c1
Show InChI InChI=1S/C24H18FN5O/c1-28-14-19-18(3-2-4-21(19)27-28)15-5-6-16(20(25)11-15)12-29-13-17-7-8-22-26-9-10-30(22)23(17)24(29)31/h2-11,14H,12-13H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.20E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361607
PNG
(US10221175, Compound 12)
Show SMILES Fc1cc(ccc1CN1Cc2ccc3nncn3c2C1=O)-n1cccn1
Show InChI InChI=1S/C18H13FN6O/c19-15-8-14(25-7-1-6-21-25)4-2-12(15)9-23-10-13-3-5-16-22-20-11-24(16)17(13)18(23)26/h1-8,11H,9-10H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361608
PNG
(US10221175, Compound 13)
Show SMILES Fc1cc(cc(F)c1CN1Cc2ccc3nncn3c2C1=O)-c1cnc2ccccc2c1
Show InChI InChI=1S/C24H15F2N5O/c25-19-8-16(17-7-14-3-1-2-4-21(14)27-10-17)9-20(26)18(19)12-30-11-15-5-6-22-29-28-13-31(22)23(15)24(30)32/h1-10,13H,11-12H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.82E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361601
PNG
(US10221175, Compound 6)
Show SMILES Cn1cc2cc(ccc2n1)-c1cc(F)c(CN2Cc3ccc4nncn4c3C2=O)c(F)c1
Show InChI InChI=1S/C23H16F2N6O/c1-29-9-16-6-13(2-4-20(16)28-29)15-7-18(24)17(19(25)8-15)11-30-10-14-3-5-21-27-26-12-31(21)22(14)23(30)32/h2-9,12H,10-11H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 488n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361612
PNG
(US10221175, Compound 17)
Show SMILES Cc1cc(cc2cn(C)nc12)-c1ccc(CN2Cc3ccc4nncn4c3C2=O)c(F)c1
Show InChI InChI=1S/C24H19FN6O/c1-14-7-18(8-19-10-29(2)28-22(14)19)15-3-4-16(20(25)9-15)11-30-12-17-5-6-21-27-26-13-31(21)23(17)24(30)32/h3-10,13H,11-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 618n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361629
PNG
(US10221175, Compound 34)
Show SMILES Cn1cc2cc(ccc2n1)-c1ccc(CN2Cc3ccc4nccn4c3C2=O)c(F)c1
Show InChI InChI=1S/C24H18FN5O/c1-28-12-19-10-15(4-6-21(19)27-28)16-2-3-17(20(25)11-16)13-29-14-18-5-7-22-26-8-9-30(22)23(18)24(29)31/h2-12H,13-14H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.90E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361597
PNG
(A. Preparation of 7-(2-fluoro-4-(2-methyl-2H-indaz...)
Show SMILES Cn1cc2c(cccc2n1)-c1ccc(CN2Cc3ccc4nncn4c3C2=O)c(F)c1
Show InChI InChI=1S/C23H17FN6O/c1-28-12-18-17(3-2-4-20(18)27-28)14-5-6-15(19(24)9-14)10-29-11-16-7-8-21-26-25-13-30(21)22(16)23(29)31/h2-9,12-13H,10-11H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 688n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361599
PNG
(US10221175, Compound 4)
Show SMILES Fc1cc(ccc1CN1Cc2ccc3nncn3c2C1=O)-c1cnc2ccccc2c1
Show InChI InChI=1S/C24H16FN5O/c25-20-10-15(19-9-16-3-1-2-4-21(16)26-11-19)5-6-17(20)12-29-13-18-7-8-22-28-27-14-30(22)23(18)24(29)31/h1-11,14H,12-13H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.75E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361614
PNG
(US10221175, Compound 19)
Show SMILES Cc1nnc2ccc3CN(Cc4c(F)cc(cc4F)-c4cccc5nn(C)cc45)C(=O)c3n12
Show InChI InChI=1S/C24H18F2N6O/c1-13-27-28-22-7-6-14-10-31(24(33)23(14)32(13)22)12-18-19(25)8-15(9-20(18)26)16-4-3-5-21-17(16)11-30(2)29-21/h3-9,11H,10,12H2,1-2H3
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n/an/an/an/a 1.41E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361615
PNG
(US10221175, Compound 20)
Show SMILES Cc1nnc2ccc3CN(Cc4ccc(cc4F)-c4cc(C)c5nn(C)cc5c4)C(=O)c3n12
Show InChI InChI=1S/C25H21FN6O/c1-14-8-19(9-20-11-30(3)29-23(14)20)16-4-5-17(21(26)10-16)12-31-13-18-6-7-22-28-27-15(2)32(22)24(18)25(31)33/h4-11H,12-13H2,1-3H3
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n/an/an/an/a 2.10E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361619
PNG
(US10221175, Compound 24)
Show SMILES Fc1ccc(cc1CN1Cc2ccc3nncn3c2C1=O)-c1cnc2ccccc2c1
Show InChI InChI=1S/C24H16FN5O/c25-20-7-5-15(18-10-16-3-1-2-4-21(16)26-11-18)9-19(20)13-29-12-17-6-8-22-28-27-14-30(22)23(17)24(29)31/h1-11,14H,12-13H2
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n/an/an/an/a 3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361622
PNG
(US10221175, Compound 27)
Show SMILES Cn1cc(cn1)-c1ccc(CN2Cc3ccc4nccn4c3C2=O)c(F)c1
Show InChI InChI=1S/C20H16FN5O/c1-24-10-16(9-23-24)13-2-3-14(17(21)8-13)11-25-12-15-4-5-18-22-6-7-26(18)19(15)20(25)27/h2-10H,11-12H2,1H3
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US Patent
n/an/an/an/a 2.26E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361625
PNG
(US10221175, Compound 30)
Show SMILES Cn1cc(cn1)-c1ccc(CN2Cc3ccc4ncnn4c3C2=O)c(F)c1
Show InChI InChI=1S/C19H15FN6O/c1-24-8-15(7-22-24)12-2-3-13(16(20)6-12)9-25-10-14-4-5-17-21-11-23-26(17)18(14)19(25)27/h2-8,11H,9-10H2,1H3
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n/an/an/an/a 677n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361630
PNG
(US10221175, Compound 35)
Show SMILES Cn1cc2cc(ccc2n1)-c1cc(F)c(CN2Cc3ccc4nccn4c3C2=O)c(F)c1
Show InChI InChI=1S/C24H17F2N5O/c1-29-11-17-8-14(2-4-21(17)28-29)16-9-19(25)18(20(26)10-16)13-30-12-15-3-5-22-27-6-7-31(22)23(15)24(30)32/h2-11H,12-13H2,1H3
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n/an/an/an/a 1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361634
PNG
(US10221175, Compound 39)
Show SMILES Fc1cc(cc(F)c1CN1Cc2ccc3nccn3c2C1=O)-c1ccc2ncccc2c1
Show InChI InChI=1S/C25H16F2N4O/c26-20-11-18(15-3-5-22-16(10-15)2-1-7-28-22)12-21(27)19(20)14-30-13-17-4-6-23-29-8-9-31(23)24(17)25(30)32/h1-12H,13-14H2
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n/an/an/an/a 857n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361637
PNG
(US10221175, Compound 42)
Show SMILES O=C1N(Cc2ccc(cc2)-n2nccn2)Cc2ccc3nccn3c12
Show InChI InChI=1S/C18H14N6O/c25-18-17-14(3-6-16-19-9-10-23(16)17)12-22(18)11-13-1-4-15(5-2-13)24-20-7-8-21-24/h1-10H,11-12H2
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n/an/an/an/a 1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361596
PNG
(A. Preparation of 7-(2,6-difluoro-4-(2-methyl-2h-i...)
Show SMILES Cn1cc2c(cccc2n1)-c1cc(F)c(CN2Cc3ccc4nncn4c3C2=O)c(F)c1
Show InChI InChI=1S/C23H16F2N6O/c1-29-10-16-15(3-2-4-20(16)28-29)14-7-18(24)17(19(25)8-14)11-30-9-13-5-6-21-27-26-12-31(21)22(13)23(30)32/h2-8,10,12H,9,11H2,1H3
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n/an/an/an/a 952n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361600
PNG
(US10221175, Compound 5)
Show SMILES Fc1cc(cc(F)c1CN1Cc2ccc3nncn3c2C1=O)-c1ccc2ncccc2c1
Show InChI InChI=1S/C24H15F2N5O/c25-19-9-17(14-3-5-21-15(8-14)2-1-7-27-21)10-20(26)18(19)12-30-11-16-4-6-22-29-28-13-31(22)23(16)24(30)32/h1-10,13H,11-12H2
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n/an/an/an/a 743n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361606
PNG
(US10221175, Compound 11)
Show SMILES Cn1cc(cn1)-c1ccc(CN2Cc3ccc4nncn4c3C2=O)c(F)c1
Show InChI InChI=1S/C19H15FN6O/c1-24-8-15(7-22-24)12-2-3-13(16(20)6-12)9-25-10-14-4-5-17-23-21-11-26(17)18(14)19(25)27/h2-8,11H,9-10H2,1H3
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n/an/an/an/a 856n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361611
PNG
(US10221175, Compound 16)
Show SMILES Cc1nnc2ccc3CN(Cc4ccc(cc4F)-c4ccc5nn(C)cc5c4)C(=O)c3n12
Show InChI InChI=1S/C24H19FN6O/c1-14-26-27-22-8-6-18-13-30(24(32)23(18)31(14)22)12-17-4-3-16(10-20(17)25)15-5-7-21-19(9-15)11-29(2)28-21/h3-11H,12-13H2,1-2H3
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n/an/an/an/a 1.21E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361613
PNG
(US10221175, Compound 18)
Show SMILES Cc1nnc2ccc3CN(Cc4ccc(cc4F)-c4ccc(C)c5nn(C)cc45)C(=O)c3n12
Show InChI InChI=1S/C25H21FN6O/c1-14-4-8-19(20-13-30(3)29-23(14)20)16-5-6-17(21(26)10-16)11-31-12-18-7-9-22-28-27-15(2)32(22)24(18)25(31)33/h4-10,13H,11-12H2,1-3H3
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n/an/an/an/a 2.14E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361604
PNG
(A. Preparation of 7-(2-fluoro-4-(2-methyl-2H-indaz...)
Show SMILES Cn1cc2cc(ccc2n1)-c1ccc(CN2Cc3ccc4nncn4c3C2=O)c(F)c1
Show InChI InChI=1S/C23H17FN6O/c1-28-10-18-8-14(4-6-20(18)27-28)15-2-3-16(19(24)9-15)11-29-12-17-5-7-21-26-25-13-30(21)22(17)23(29)31/h2-10,13H,11-12H2,1H3
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n/an/an/an/a 502n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361609
PNG
(US10221175, Compound 14)
Show SMILES Cc1nnc2ccc3CN(Cc4c(F)cc(cc4F)-c4cnn(C)c4)C(=O)c3n12
Show InChI InChI=1S/C20H16F2N6O/c1-11-24-25-18-4-3-12-9-27(20(29)19(12)28(11)18)10-15-16(21)5-13(6-17(15)22)14-7-23-26(2)8-14/h3-8H,9-10H2,1-2H3
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n/an/an/an/a 1.79E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361616
PNG
(US10221175, Compound 21)
Show SMILES Cn1cc(cn1)-c1ccc(F)c(CN2Cc3ccc4nncn4c3C2=O)c1
Show InChI InChI=1S/C19H15FN6O/c1-24-8-15(7-22-24)12-2-4-16(20)14(6-12)10-25-9-13-3-5-17-23-21-11-26(17)18(13)19(25)27/h2-8,11H,9-10H2,1H3
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n/an/an/an/a 1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361617
PNG
(US10221175, Compound 22)
Show SMILES Cn1cc2cc(ccc2n1)-c1ccc(F)c(CN2Cc3ccc4nncn4c3C2=O)c1
Show InChI InChI=1S/C23H17FN6O/c1-28-10-18-9-15(3-6-20(18)27-28)14-2-5-19(24)17(8-14)12-29-11-16-4-7-21-26-25-13-30(21)22(16)23(29)31/h2-10,13H,11-12H2,1H3
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n/an/an/an/a 1.31E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361624
PNG
(US10221175, Compound 29)
Show SMILES Cc1cn2c3C(=O)N(Cc4c(F)cc(cc4F)-c4cnn(C)c4)Cc3ccc2n1
Show InChI InChI=1S/C21H17F2N5O/c1-12-8-28-19(25-12)4-3-13-10-27(21(29)20(13)28)11-16-17(22)5-14(6-18(16)23)15-7-24-26(2)9-15/h3-9H,10-11H2,1-2H3
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n/an/an/an/a 3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%