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Patent code US10221182

Compile Data Set for Download or QSAR
Found 98 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 17n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
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n/an/a 17n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 17n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361992
PNG
(US10221182, Compound E1-1.4 | US10221182, Compound...)
Show SMILES Cc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
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n/an/a 18.5n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361992
PNG
(US10221182, Compound E1-1.4 | US10221182, Compound...)
Show SMILES Cc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
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n/an/a 18.5n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 21.2n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 21.2n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 21.2n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361992
PNG
(US10221182, Compound E1-1.4 | US10221182, Compound...)
Show SMILES Cc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
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n/an/a 21.9n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361992
PNG
(US10221182, Compound E1-1.4 | US10221182, Compound...)
Show SMILES Cc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
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n/an/a 21.9n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362001
PNG
(US10221182, Compound E1-1.7 | US10221182, Compound...)
Show SMILES FCc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
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n/an/a 22.4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362001
PNG
(US10221182, Compound E1-1.7 | US10221182, Compound...)
Show SMILES FCc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 22.4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362001
PNG
(US10221182, Compound E1-1.7 | US10221182, Compound...)
Show SMILES FCc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 22.4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM280739
PNG
(US10030026, Compound LX-1 | US10221182, Compound L...)
Show SMILES FC(F)(F)c1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ncc12
Show InChI InChI=1S/C19H19F5N6/c20-18(21,12-1-3-13(4-2-12)19(22,23)24)10-30-7-5-14(6-8-30)28-16-15-9-27-29-17(15)26-11-25-16/h1-4,9,11,14H,5-8,10H2,(H2,25,26,27,28,29)
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n/an/a 24n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM280739
PNG
(US10030026, Compound LX-1 | US10221182, Compound L...)
Show SMILES FC(F)(F)c1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ncc12
Show InChI InChI=1S/C19H19F5N6/c20-18(21,12-1-3-13(4-2-12)19(22,23)24)10-30-7-5-14(6-8-30)28-16-15-9-27-29-17(15)26-11-25-16/h1-4,9,11,14H,5-8,10H2,(H2,25,26,27,28,29)
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n/an/a 24n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361989
PNG
(US10221182, Compound E1-1.3 | US10221182, Compound...)
Show SMILES FC1(F)CN(CCc2ccc(Cl)cc2)CCC1Nc1ncnc2[nH]ncc12
PDB
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n/an/a 25n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361989
PNG
(US10221182, Compound E1-1.3 | US10221182, Compound...)
Show SMILES FC1(F)CN(CCc2ccc(Cl)cc2)CCC1Nc1ncnc2[nH]ncc12
PDB
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n/an/a 25n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361989
PNG
(US10221182, Compound E1-1.3 | US10221182, Compound...)
Show SMILES FC1(F)CN(CCc2ccc(Cl)cc2)CCC1Nc1ncnc2[nH]ncc12
PDB
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n/an/a 25n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362003
PNG
(US10221182, Compound E1-1.16 | US10221182, Compoun...)
Show SMILES Fc1cc(Cl)ccc1CCN1CCC(Nc2ncnc3[nH]ncc23)C(F)(F)C1
PDB
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n/an/a 27.9n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362003
PNG
(US10221182, Compound E1-1.16 | US10221182, Compoun...)
Show SMILES Fc1cc(Cl)ccc1CCN1CCC(Nc2ncnc3[nH]ncc23)C(F)(F)C1
PDB
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n/an/a 27.9n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362003
PNG
(US10221182, Compound E1-1.16 | US10221182, Compoun...)
Show SMILES Fc1cc(Cl)ccc1CCN1CCC(Nc2ncnc3[nH]ncc23)C(F)(F)C1
PDB
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n/an/a 27.9n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361989
PNG
(US10221182, Compound E1-1.3 | US10221182, Compound...)
Show SMILES FC1(F)CN(CCc2ccc(Cl)cc2)CCC1Nc1ncnc2[nH]ncc12
PDB
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n/an/a 31.7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361989
PNG
(US10221182, Compound E1-1.3 | US10221182, Compound...)
Show SMILES FC1(F)CN(CCc2ccc(Cl)cc2)CCC1Nc1ncnc2[nH]ncc12
PDB
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n/an/a 31.7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361989
PNG
(US10221182, Compound E1-1.3 | US10221182, Compound...)
Show SMILES FC1(F)CN(CCc2ccc(Cl)cc2)CCC1Nc1ncnc2[nH]ncc12
PDB
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n/an/a 31.7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361982
PNG
(US10221182, Compound E1-1.5 | US10221182, Compound...)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
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n/an/a 32.9n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361982
PNG
(US10221182, Compound E1-1.5 | US10221182, Compound...)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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US Patent
n/an/a 32.9n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361982
PNG
(US10221182, Compound E1-1.5 | US10221182, Compound...)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 32.9n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361982
PNG
(US10221182, Compound E1-1.5 | US10221182, Compound...)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
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n/an/a 37.8n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361982
PNG
(US10221182, Compound E1-1.5 | US10221182, Compound...)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 37.8n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361982
PNG
(US10221182, Compound E1-1.5 | US10221182, Compound...)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 37.8n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362001
PNG
(US10221182, Compound E1-1.7 | US10221182, Compound...)
Show SMILES FCc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
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n/an/a 38.1n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362001
PNG
(US10221182, Compound E1-1.7 | US10221182, Compound...)
Show SMILES FCc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 38.1n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362003
PNG
(US10221182, Compound E1-1.16 | US10221182, Compoun...)
Show SMILES Fc1cc(Cl)ccc1CCN1CCC(Nc2ncnc3[nH]ncc23)C(F)(F)C1
PDB
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n/an/a 61.9n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362003
PNG
(US10221182, Compound E1-1.16 | US10221182, Compoun...)
Show SMILES Fc1cc(Cl)ccc1CCN1CCC(Nc2ncnc3[nH]ncc23)C(F)(F)C1
PDB
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n/an/a 61.9n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361991
PNG
(US10221182, Compound C-1.2)
Show SMILES Fc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 68.3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361991
PNG
(US10221182, Compound C-1.2)
Show SMILES Fc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 68.3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361991
PNG
(US10221182, Compound C-1.2)
Show SMILES Fc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 68.3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362005
PNG
(US10221182, Compound E1-1.11)
Show SMILES FC(F)(F)Oc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 68.4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362005
PNG
(US10221182, Compound E1-1.11)
Show SMILES FC(F)(F)Oc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 68.4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361995
PNG
(US10221182, Compound C-1.34)
Show SMILES Cc1n[nH]c2ncnc(NC3CCN(CCc4ccc(cc4)C(F)(F)F)CC3(F)F)c12
PDB
MMDB

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n/an/a 72.8n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361995
PNG
(US10221182, Compound C-1.34)
Show SMILES Cc1n[nH]c2ncnc(NC3CCN(CCc4ccc(cc4)C(F)(F)F)CC3(F)F)c12
PDB
MMDB

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n/an/a 72.8n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361994
PNG
(US10221182, Compound C-1.15)
Show SMILES Fc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)c(F)c1
PDB
MMDB

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n/an/a 78.9n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361994
PNG
(US10221182, Compound C-1.15)
Show SMILES Fc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)c(F)c1
PDB
MMDB

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n/an/a 78.9n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361984
PNG
(US10221182, Compound C-1.1 | US10221182, Compound ...)
Show SMILES FC1(F)CN(CCc2ccccc2)CCC1Nc1ncnc2[nH]ncc12
PDB
MMDB

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n/an/a 83.8n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361984
PNG
(US10221182, Compound C-1.1 | US10221182, Compound ...)
Show SMILES FC1(F)CN(CCc2ccccc2)CCC1Nc1ncnc2[nH]ncc12
PDB
MMDB

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n/an/a 83.8n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361984
PNG
(US10221182, Compound C-1.1 | US10221182, Compound ...)
Show SMILES FC1(F)CN(CCc2ccccc2)CCC1Nc1ncnc2[nH]ncc12
PDB
MMDB

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n/an/a 98.8n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361984
PNG
(US10221182, Compound C-1.1 | US10221182, Compound ...)
Show SMILES FC1(F)CN(CCc2ccccc2)CCC1Nc1ncnc2[nH]ncc12
PDB
MMDB

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n/an/a 98.8n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361986
PNG
(US10221182, Compound C-1.33)
Show SMILES CN(C1CCN(CCc2ccc(cc2)C(F)(F)F)CC1(F)F)c1ncnc2[nH]ncc12
PDB
MMDB

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n/an/a 103n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361986
PNG
(US10221182, Compound C-1.33)
Show SMILES CN(C1CCN(CCc2ccc(cc2)C(F)(F)F)CC1(F)F)c1ncnc2[nH]ncc12
PDB
MMDB

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n/an/a 103n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361985
PNG
(US10221182, Compound C-2.5)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ccc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 105n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361985
PNG
(US10221182, Compound C-2.5)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ccc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 105n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361998
PNG
(US10221182, Compound C-1.36)
Show SMILES FC(F)(F)c1cccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)c1
PDB
MMDB

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n/an/a 291n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361998
PNG
(US10221182, Compound C-1.36)
Show SMILES FC(F)(F)c1cccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)c1
PDB
MMDB

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n/an/a 291n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361998
PNG
(US10221182, Compound C-1.36)
Show SMILES FC(F)(F)c1cccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)c1
PDB
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n/an/a 291n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361997
PNG
(US10221182, Compound C-1.35)
Show SMILES Fc1ccc(F)c(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)c1
PDB
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n/an/a 329n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361997
PNG
(US10221182, Compound C-1.35)
Show SMILES Fc1ccc(F)c(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)c1
PDB
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n/an/a 329n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361987
PNG
(US10221182, Compound C-3.5)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cn1
PDB
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n/an/a 822n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361987
PNG
(US10221182, Compound C-3.5)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cn1
PDB
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n/an/a 822n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM280739
PNG
(US10030026, Compound LX-1 | US10221182, Compound L...)
Show SMILES FC(F)(F)c1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ncc12
Show InChI InChI=1S/C19H19F5N6/c20-18(21,12-1-3-13(4-2-12)19(22,23)24)10-30-7-5-14(6-8-30)28-16-15-9-27-29-17(15)26-11-25-16/h1-4,9,11,14H,5-8,10H2,(H2,25,26,27,28,29)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361996
PNG
(US10221182, Compound C-4.5)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ccc34)C(F)(F)C2)cn1
PDB
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n/an/a 1.74E+3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361996
PNG
(US10221182, Compound C-4.5)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ccc34)C(F)(F)C2)cn1
PDB
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n/an/a 1.74E+3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361988
PNG
(US10221182, Compound C-3.4)
Show SMILES Cc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cn1
PDB
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n/an/a 2.27E+3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361988
PNG
(US10221182, Compound C-3.4)
Show SMILES Cc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cn1
PDB
MMDB

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n/an/a 2.27E+3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
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n/an/a 3.50E+3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37 C. in a humidified CO2 incubator in the grow...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM280739
PNG
(US10030026, Compound LX-1 | US10221182, Compound L...)
Show SMILES FC(F)(F)c1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ncc12
Show InChI InChI=1S/C19H19F5N6/c20-18(21,12-1-3-13(4-2-12)19(22,23)24)10-30-7-5-14(6-8-30)28-16-15-9-27-29-17(15)26-11-25-16/h1-4,9,11,14H,5-8,10H2,(H2,25,26,27,28,29)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37 C. in a humidified CO2 incubator in the grow...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM361982
PNG
(US10221182, Compound E1-1.5 | US10221182, Compound...)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
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n/an/a 7.60E+3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37 C. in a humidified CO2 incubator in the grow...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM361982
PNG
(US10221182, Compound E1-1.5 | US10221182, Compound...)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
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n/an/a 9.80E+3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37 C. in a humidified CO2 incubator in the grow...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM362001
PNG
(US10221182, Compound E1-1.7 | US10221182, Compound...)
Show SMILES FCc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM362005
PNG
(US10221182, Compound E1-1.11)
Show SMILES FC(F)(F)Oc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361995
PNG
(US10221182, Compound C-1.34)
Show SMILES Cc1n[nH]c2ncnc(NC3CCN(CCc4ccc(cc4)C(F)(F)F)CC3(F)F)c12
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361998
PNG
(US10221182, Compound C-1.36)
Show SMILES FC(F)(F)c1cccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)c1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM362003
PNG
(US10221182, Compound E1-1.16 | US10221182, Compoun...)
Show SMILES Fc1cc(Cl)ccc1CCN1CCC(Nc2ncnc3[nH]ncc23)C(F)(F)C1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361989
PNG
(US10221182, Compound E1-1.3 | US10221182, Compound...)
Show SMILES FC1(F)CN(CCc2ccc(Cl)cc2)CCC1Nc1ncnc2[nH]ncc12
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361986
PNG
(US10221182, Compound C-1.33)
Show SMILES CN(C1CCN(CCc2ccc(cc2)C(F)(F)F)CC1(F)F)c1ncnc2[nH]ncc12
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361985
PNG
(US10221182, Compound C-2.5)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ccc34)C(F)(F)C2)cc1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361982
PNG
(US10221182, Compound E1-1.5 | US10221182, Compound...)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361984
PNG
(US10221182, Compound C-1.1 | US10221182, Compound ...)
Show SMILES FC1(F)CN(CCc2ccccc2)CCC1Nc1ncnc2[nH]ncc12
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361991
PNG
(US10221182, Compound C-1.2)
Show SMILES Fc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361992
PNG
(US10221182, Compound E1-1.4 | US10221182, Compound...)
Show SMILES Cc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361996
PNG
(US10221182, Compound C-4.5)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ccc34)C(F)(F)C2)cn1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM362001
PNG
(US10221182, Compound E1-1.7 | US10221182, Compound...)
Show SMILES FCc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361987
PNG
(US10221182, Compound C-3.5)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cn1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361989
PNG
(US10221182, Compound E1-1.3 | US10221182, Compound...)
Show SMILES FC1(F)CN(CCc2ccc(Cl)cc2)CCC1Nc1ncnc2[nH]ncc12
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361982
PNG
(US10221182, Compound E1-1.5 | US10221182, Compound...)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM362003
PNG
(US10221182, Compound E1-1.16 | US10221182, Compoun...)
Show SMILES Fc1cc(Cl)ccc1CCN1CCC(Nc2ncnc3[nH]ncc23)C(F)(F)C1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361992
PNG
(US10221182, Compound E1-1.4 | US10221182, Compound...)
Show SMILES Cc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361984
PNG
(US10221182, Compound C-1.1 | US10221182, Compound ...)
Show SMILES FC1(F)CN(CCc2ccccc2)CCC1Nc1ncnc2[nH]ncc12
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361988
PNG
(US10221182, Compound C-3.4)
Show SMILES Cc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cn1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361994
PNG
(US10221182, Compound C-1.15)
Show SMILES Fc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)c(F)c1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM361997
PNG
(US10221182, Compound C-1.35)
Show SMILES Fc1ccc(F)c(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)c1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
TBD


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM361982
PNG
(US10221182, Compound E1-1.5 | US10221182, Compound...)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB

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n/an/a 1.52E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM361992
PNG
(US10221182, Compound E1-1.4 | US10221182, Compound...)
Show SMILES Cc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 1.55E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37 C. in a humidified CO2 incubator in the grow...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM361991
PNG
(US10221182, Compound C-1.2)
Show SMILES Fc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 1.63E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37 C. in a humidified CO2 incubator in the grow...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM361992
PNG
(US10221182, Compound E1-1.4 | US10221182, Compound...)
Show SMILES Cc1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB
MMDB

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n/an/a 2.19E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37 C. in a humidified CO2 incubator in the grow...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM361982
PNG
(US10221182, Compound E1-1.5 | US10221182, Compound...)
Show SMILES FC(F)(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1
PDB

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n/an/a 3.41E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM361984
PNG
(US10221182, Compound C-1.1 | US10221182, Compound ...)
Show SMILES FC1(F)CN(CCc2ccccc2)CCC1Nc1ncnc2[nH]ncc12
PDB
MMDB

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n/an/a 7.10E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37 C. in a humidified CO2 incubator in the grow...


US Patent US10221182 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%