BindingDB logo
myBDB logout

Patent code US10227327

Compile Data Set for Download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GIM-1


(Pseudomonas aeruginosa)
BDBM367681
PNG
(1-(pyridin-2-yl)-N-(pyridin-2-ylmethyl)-N-((1-(3,4...)
Show SMILES COc1cc(Cn2cc(CN(Cc3ccccn3)Cc3ccccn3)nn2)cc(OC)c1OC
Show InChI InChI=1S/C25H28N6O3/c1-32-23-12-19(13-24(33-2)25(23)34-3)14-31-18-22(28-29-31)17-30(15-20-8-4-6-10-26-20)16-21-9-5-7-11-27-21/h4-13,18H,14-17H2,1-3H3
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 140n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
VIM-2


(Pseudomonas aeruginosa)
BDBM367675
PNG
(N,N,N′,N′-Tetrakis(2-pyridinylmethyl)-...)
Show SMILES C(CN(Cc1ccccn1)Cc1ccccn1)N(Cc1ccccn1)Cc1ccccn1
Show InChI InChI=1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
Beta-lactamase NDM-1


(Klebsiella pneumoniae)
BDBM367676
PNG
(1-(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)-N,N-...)
Show SMILES COc1ccc(Cn2cc(CN(Cc3ccccn3)Cc3ccccn3)nn2)cc1
Show InChI InChI=1S/C23H24N6O/c1-30-23-10-8-19(9-11-23)14-29-18-22(26-27-29)17-28(15-20-6-2-4-12-24-20)16-21-7-3-5-13-25-21/h2-13,18H,14-17H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 380n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
GIM-1


(Pseudomonas aeruginosa)
BDBM367678
PNG
((R)-1-(((R)-1-((4-(2-(bis(pyridin-2-ylmethyl)amino...)
Show SMILES C[C@@H]([NH3+])C(=O)N[C@H](C)C(=O)NCCc1ccc(NC(=O)CN(Cc2ccccn2)Cc2ccccn2)cc1
Show InChI InChI=1/C28H35N7O3/c1-20(29)27(37)33-21(2)28(38)32-16-13-22-9-11-23(12-10-22)34-26(36)19-35(17-24-7-3-5-14-30-24)18-25-8-4-6-15-31-25/h3-12,14-15,20-21H,13,16-19,29H2,1-2H3,(H,32,38)(H,33,37)(H,34,36)/p+1/t20-,21-/s2
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 400n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
Beta-lactamase NDM-1


(Klebsiella pneumoniae)
BDBM367678
PNG
((R)-1-(((R)-1-((4-(2-(bis(pyridin-2-ylmethyl)amino...)
Show SMILES C[C@@H]([NH3+])C(=O)N[C@H](C)C(=O)NCCc1ccc(NC(=O)CN(Cc2ccccn2)Cc2ccccn2)cc1
Show InChI InChI=1/C28H35N7O3/c1-20(29)27(37)33-21(2)28(38)32-16-13-22-9-11-23(12-10-22)34-26(36)19-35(17-24-7-3-5-14-30-24)18-25-8-4-6-15-31-25/h3-12,14-15,20-21H,13,16-19,29H2,1-2H3,(H,32,38)(H,33,37)(H,34,36)/p+1/t20-,21-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 520n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
Beta-lactamase NDM-1


(Klebsiella pneumoniae)
BDBM367683
PNG
(1-(1-β-bromo-4-methoxybenzyl)-1H-1,2,3-triazo...)
Show SMILES COc1ccc(Cn2cc(CN(Cc3ccccn3)Cc3ccccn3)nn2)cc1Br
Show InChI InChI=1S/C23H23BrN6O/c1-31-23-9-8-18(12-22(23)24)13-30-17-21(27-28-30)16-29(14-19-6-2-4-10-25-19)15-20-7-3-5-11-26-20/h2-12,17H,13-16H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 600n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
GIM-1


(Pseudomonas aeruginosa)
BDBM367675
PNG
(N,N,N′,N′-Tetrakis(2-pyridinylmethyl)-...)
Show SMILES C(CN(Cc1ccccn1)Cc1ccccn1)N(Cc1ccccn1)Cc1ccccn1
Show InChI InChI=1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 610n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
GIM-1


(Pseudomonas aeruginosa)
BDBM367680
PNG
(1-(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)-N,N-bi...)
Show SMILES [O-][N+](=O)c1ccc(Cn2cc(CN(Cc3ccccn3)Cc3ccccn3)nn2)cc1
Show InChI InChI=1S/C22H21N7O2/c30-29(31)22-9-7-18(8-10-22)13-28-17-21(25-26-28)16-27(14-19-5-1-3-11-23-19)15-20-6-2-4-12-24-20/h1-12,17H,13-16H2
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 710n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
Beta-lactamase NDM-1


(Klebsiella pneumoniae)
BDBM367677
PNG
(1-(1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)-N,N-...)
Show SMILES COc1ccc(cc1)-n1cc(CN(Cc2ccccn2)Cc2ccccn2)nn1
Show InChI InChI=1S/C22H22N6O/c1-29-22-10-8-21(9-11-22)28-17-20(25-26-28)16-27(14-18-6-2-4-12-23-18)15-19-7-3-5-13-24-19/h2-13,17H,14-16H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 720n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
GIM-1


(Pseudomonas aeruginosa)
BDBM367679
PNG
(1-(pyridin-2-yl)-N-(pyridin-2-ylmethyl)-N-((1-(3,4...)
Show SMILES COc1cc(cc(OC)c1OC)-n1cc(CN(Cc2ccccn2)Cc2ccccn2)nn1
Show InChI InChI=1S/C24H26N6O3/c1-31-22-12-21(13-23(32-2)24(22)33-3)30-17-20(27-28-30)16-29(14-18-8-4-6-10-25-18)15-19-9-5-7-11-26-19/h4-13,17H,14-16H2,1-3H3
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 790n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
GIM-1


(Pseudomonas aeruginosa)
BDBM367684
PNG
(1-(1-(2,4-dimethoxyphenyl)-1H-1,2,3-triazol-4-yl)-...)
Show SMILES COc1ccc(c(OC)c1)-n1cc(CN(Cc2ccccn2)Cc2ccccn2)nn1
Show InChI InChI=1S/C23H24N6O2/c1-30-21-9-10-22(23(13-21)31-2)29-17-20(26-27-29)16-28(14-18-7-3-5-11-24-18)15-19-8-4-6-12-25-19/h3-13,17H,14-16H2,1-2H3
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 860n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
GIM-1


(Pseudomonas aeruginosa)
BDBM367682
PNG
(1-(1-(4-methoxy-3-nitrobenzyl)-1H-1,2,3-triazol-4-...)
Show SMILES COc1ccc(Cn2cc(CN(Cc3ccccn3)Cc3ccccn3)nn2)cc1[N+]([O-])=O
Show InChI InChI=1S/C23H23N7O3/c1-33-23-9-8-18(12-22(23)30(31)32)13-29-17-21(26-27-29)16-28(14-19-6-2-4-10-24-19)15-20-7-3-5-11-25-20/h2-12,17H,13-16H2,1H3
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.03E+3n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
Beta-lactamase NDM-1


(Klebsiella pneumoniae)
BDBM367682
PNG
(1-(1-(4-methoxy-3-nitrobenzyl)-1H-1,2,3-triazol-4-...)
Show SMILES COc1ccc(Cn2cc(CN(Cc3ccccn3)Cc3ccccn3)nn2)cc1[N+]([O-])=O
Show InChI InChI=1S/C23H23N7O3/c1-33-23-9-8-18(12-22(23)30(31)32)13-29-17-21(26-27-29)16-28(14-19-6-2-4-10-24-19)15-20-7-3-5-11-25-20/h2-12,17H,13-16H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.06E+3n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
GIM-1


(Pseudomonas aeruginosa)
BDBM367685
PNG
(1-(pyridin-2-yl)-N-(pyridin-2-ylmethyl)-N-((1-(4-(...)
Show SMILES FC(F)(F)c1ccc(cc1)-n1cc(CN(Cc2ccccn2)Cc2ccccn2)nn1
Show InChI InChI=1S/C22H19F3N6/c23-22(24,25)17-7-9-21(10-8-17)31-16-20(28-29-31)15-30(13-18-5-1-3-11-26-18)14-19-6-2-4-12-27-19/h1-12,16H,13-15H2
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
GIM-1


(Pseudomonas aeruginosa)
BDBM367677
PNG
(1-(1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)-N,N-...)
Show SMILES COc1ccc(cc1)-n1cc(CN(Cc2ccccn2)Cc2ccccn2)nn1
Show InChI InChI=1S/C22H22N6O/c1-29-22-10-8-21(9-11-22)28-17-20(25-26-28)16-27(14-18-6-2-4-12-23-18)15-19-7-3-5-13-24-19/h2-13,17H,14-16H2,1H3
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.43E+3n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
GIM-1


(Pseudomonas aeruginosa)
BDBM367676
PNG
(1-(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)-N,N-...)
Show SMILES COc1ccc(Cn2cc(CN(Cc3ccccn3)Cc3ccccn3)nn2)cc1
Show InChI InChI=1S/C23H24N6O/c1-30-23-10-8-19(9-11-23)14-29-18-22(26-27-29)17-28(15-20-6-2-4-12-24-20)16-21-7-3-5-13-25-21/h2-13,18H,14-17H2,1H3
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.26E+3n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
GIM-1


(Pseudomonas aeruginosa)
BDBM367683
PNG
(1-(1-β-bromo-4-methoxybenzyl)-1H-1,2,3-triazo...)
Show SMILES COc1ccc(Cn2cc(CN(Cc3ccccn3)Cc3ccccn3)nn2)cc1Br
Show InChI InChI=1S/C23H23BrN6O/c1-31-23-9-8-18(12-22(23)24)13-30-17-21(27-28-30)16-29(14-19-6-2-4-10-25-19)15-20-7-3-5-11-26-20/h2-12,17H,13-16H2,1H3
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.15E+3n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
VIM-2


(Pseudomonas aeruginosa)
BDBM367679
PNG
(1-(pyridin-2-yl)-N-(pyridin-2-ylmethyl)-N-((1-(3,4...)
Show SMILES COc1cc(cc(OC)c1OC)-n1cc(CN(Cc2ccccn2)Cc2ccccn2)nn1
Show InChI InChI=1S/C24H26N6O3/c1-31-22-12-21(13-23(32-2)24(22)33-3)30-17-20(27-28-30)16-29(14-18-8-4-6-10-25-18)15-19-9-5-7-11-26-19/h4-13,17H,14-16H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.15E+4n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
VIM-2


(Pseudomonas aeruginosa)
BDBM367684
PNG
(1-(1-(2,4-dimethoxyphenyl)-1H-1,2,3-triazol-4-yl)-...)
Show SMILES COc1ccc(c(OC)c1)-n1cc(CN(Cc2ccccn2)Cc2ccccn2)nn1
Show InChI InChI=1S/C23H24N6O2/c1-30-21-9-10-22(23(13-21)31-2)29-17-20(26-27-29)16-28(14-18-7-3-5-11-24-18)15-19-8-4-6-12-25-19/h3-13,17H,14-16H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.22E+4n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
VIM-2


(Pseudomonas aeruginosa)
BDBM367685
PNG
(1-(pyridin-2-yl)-N-(pyridin-2-ylmethyl)-N-((1-(4-(...)
Show SMILES FC(F)(F)c1ccc(cc1)-n1cc(CN(Cc2ccccn2)Cc2ccccn2)nn1
Show InChI InChI=1S/C22H19F3N6/c23-22(24,25)17-7-9-21(10-8-17)31-16-20(28-29-31)15-30(13-18-5-1-3-11-26-18)14-19-6-2-4-12-27-19/h1-12,16H,13-15H2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.29E+4n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
VIM-2


(Pseudomonas aeruginosa)
BDBM367682
PNG
(1-(1-(4-methoxy-3-nitrobenzyl)-1H-1,2,3-triazol-4-...)
Show SMILES COc1ccc(Cn2cc(CN(Cc3ccccn3)Cc3ccccn3)nn2)cc1[N+]([O-])=O
Show InChI InChI=1S/C23H23N7O3/c1-33-23-9-8-18(12-22(23)30(31)32)13-29-17-21(26-27-29)16-28(14-19-6-2-4-10-24-19)15-20-7-3-5-11-25-20/h2-12,17H,13-16H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.48E+4n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
VIM-2


(Pseudomonas aeruginosa)
BDBM367681
PNG
(1-(pyridin-2-yl)-N-(pyridin-2-ylmethyl)-N-((1-(3,4...)
Show SMILES COc1cc(Cn2cc(CN(Cc3ccccn3)Cc3ccccn3)nn2)cc(OC)c1OC
Show InChI InChI=1S/C25H28N6O3/c1-32-23-12-19(13-24(33-2)25(23)34-3)14-31-18-22(28-29-31)17-30(15-20-8-4-6-10-26-20)16-21-9-5-7-11-27-21/h4-13,18H,14-17H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.87E+4n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
VIM-2


(Pseudomonas aeruginosa)
BDBM367683
PNG
(1-(1-β-bromo-4-methoxybenzyl)-1H-1,2,3-triazo...)
Show SMILES COc1ccc(Cn2cc(CN(Cc3ccccn3)Cc3ccccn3)nn2)cc1Br
Show InChI InChI=1S/C23H23BrN6O/c1-31-23-9-8-18(12-22(23)24)13-30-17-21(27-28-30)16-29(14-19-6-2-4-10-25-19)15-20-7-3-5-11-26-20/h2-12,17H,13-16H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.90E+4n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
VIM-2


(Pseudomonas aeruginosa)
BDBM367676
PNG
(1-(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)-N,N-...)
Show SMILES COc1ccc(Cn2cc(CN(Cc3ccccn3)Cc3ccccn3)nn2)cc1
Show InChI InChI=1S/C23H24N6O/c1-30-23-10-8-19(9-11-23)14-29-18-22(26-27-29)17-28(15-20-6-2-4-12-24-20)16-21-7-3-5-13-25-21/h2-13,18H,14-17H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.98E+4n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
VIM-2


(Pseudomonas aeruginosa)
BDBM367678
PNG
((R)-1-(((R)-1-((4-(2-(bis(pyridin-2-ylmethyl)amino...)
Show SMILES C[C@@H]([NH3+])C(=O)N[C@H](C)C(=O)NCCc1ccc(NC(=O)CN(Cc2ccccn2)Cc2ccccn2)cc1
Show InChI InChI=1/C28H35N7O3/c1-20(29)27(37)33-21(2)28(38)32-16-13-22-9-11-23(12-10-22)34-26(36)19-35(17-24-7-3-5-14-30-24)18-25-8-4-6-15-31-25/h3-12,14-15,20-21H,13,16-19,29H2,1-2H3,(H,32,38)(H,33,37)(H,34,36)/p+1/t20-,21-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.28E+4n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
VIM-2


(Pseudomonas aeruginosa)
BDBM367677
PNG
(1-(1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)-N,N-...)
Show SMILES COc1ccc(cc1)-n1cc(CN(Cc2ccccn2)Cc2ccccn2)nn1
Show InChI InChI=1S/C22H22N6O/c1-29-22-10-8-21(9-11-22)28-17-20(25-26-28)16-27(14-18-6-2-4-12-23-18)15-19-7-3-5-13-24-19/h2-13,17H,14-16H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.49E+4n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
VIM-2


(Pseudomonas aeruginosa)
BDBM367680
PNG
(1-(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)-N,N-bi...)
Show SMILES [O-][N+](=O)c1ccc(Cn2cc(CN(Cc3ccccn3)Cc3ccccn3)nn2)cc1
Show InChI InChI=1S/C22H21N7O2/c30-29(31)22-9-7-18(8-10-22)13-28-17-21(25-26-28)16-27(14-19-5-1-3-11-23-19)15-20-6-2-4-12-24-20/h1-12,17H,13-16H2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.09E+4n/an/an/an/an/an/a



Universitetet | Oslo

US Patent


Assay Description
a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...


US Patent US10227327 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%