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Patent code US10227329

Compile Data Set for Download or QSAR

Found 268 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM84747
PNG
((B) ZD6474 | US10155768, Vandetanib | US10183928, ...)
Show SMILES CN1CCC(COc2cc3ncnc(Cc4ccc(Br)cc4F)c3cc2C)CC1
Show InChI InChI=1S/C23H25BrFN3O/c1-15-9-19-21(10-17-3-4-18(24)11-20(17)25)26-14-27-22(19)12-23(15)29-13-16-5-7-28(2)8-6-16/h3-4,9,11-12,14,16H,5-8,10,13H2,1-2H3
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n/an/a 1.20n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50363397
PNG
(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1
Show InChI InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
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US Patent
n/an/a 5.10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/a 7.90n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367707
PNG
(US10227329, Compound 119 | US10227329, Compound 14...)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1/C24H26FN9O/c1-14-6-20(29-21-8-15(2)31-32-21)30-23(7-14)33-11-18(12-33)24(35)28-16(3)17-4-5-22(26-9-17)34-13-19(25)10-27-34/h4-10,13,16,18H,11-12H2,1-3H3,(H,28,35)(H2,29,30,31,32)/t16-/s2
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367708
PNG
(US10227329, Compound 120)
Show SMILES Cc1cc(Nc2cc(C)cc(n2)N2CC(C)(C2)C(=O)NCc2ccc(nc2)-n2cc(F)cn2)n[nH]1
Show InChI InChI=1S/C24H26FN9O/c1-15-6-19(29-20-8-16(2)31-32-20)30-22(7-15)33-13-24(3,14-33)23(35)27-10-17-4-5-21(26-9-17)34-12-18(25)11-28-34/h4-9,11-12H,10,13-14H2,1-3H3,(H,27,35)(H2,29,30,31,32)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367710
PNG
(US10227329, Compound 122)
Show SMILES C[C@H](NC(=O)C1(F)CN(C1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cccn1
Show InChI InChI=1/C23H25FN10O/c1-14-9-18(29-19-10-15(2)31-32-19)30-22(27-14)33-12-23(24,13-33)21(35)28-16(3)17-5-6-20(25-11-17)34-8-4-7-26-34/h4-11,16H,12-13H2,1-3H3,(H,28,35)(H2,27,29,30,31,32)/t16-/s2
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367763
PNG
(US10227329, Compound 175)
Show SMILES COC1(CN(C1)c1nc(Nc2cc(C)[nH]n2)cc(C)c1C#N)C(=O)N[C@@H](C)c1ccc(nc1)-n1cccn1
Show InChI InChI=1/C26H28N10O2/c1-16-10-21(31-22-11-17(2)33-34-22)32-24(20(16)12-27)35-14-26(15-35,38-4)25(37)30-18(3)19-6-7-23(28-13-19)36-9-5-8-29-36/h5-11,13,18H,14-15H2,1-4H3,(H,30,37)(H2,31,32,33,34)/t18-/s2
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367765
PNG
(US10227329, Compound 177)
Show SMILES COC1(CN(C1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)NCc1ccc(nc1)-n1ccc(n1)C1CC1
Show InChI InChI=1S/C27H31N9O2/c1-17-10-22(30-23-12-18(2)32-33-23)31-25(11-17)35-15-27(16-35,38-3)26(37)29-14-19-4-7-24(28-13-19)36-9-8-21(34-36)20-5-6-20/h4,7-13,20H,5-6,14-16H2,1-3H3,(H,29,37)(H2,30,31,32,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367721
PNG
(US10227329, Compound 133)
Show SMILES Cc1cc(Nc2cc(C)cc(n2)N2CC[C@H]([C@H](O)C2)C(=O)NCc2ccc(nc2)-n2cccn2)n[nH]1
Show InChI InChI=1/C25H29N9O2/c1-16-10-21(29-22-12-17(2)31-32-22)30-24(11-16)33-9-6-19(20(35)15-33)25(36)27-14-18-4-5-23(26-13-18)34-8-3-7-28-34/h3-5,7-8,10-13,19-20,35H,6,9,14-15H2,1-2H3,(H,27,36)(H2,29,30,31,32)/t19-,20-/s2
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367770
PNG
(US10227329, Compound 182)
Show SMILES Cc1cc(C)n(n1)-c1ccc(CNC(=O)C2(O)CCN(CC2)c2cc(C)cc(Nc3cc(C)[nH]n3)n2)cn1
Show InChI InChI=1S/C27H33N9O2/c1-17-11-22(30-23-14-18(2)32-33-23)31-25(12-17)35-9-7-27(38,8-10-35)26(37)29-16-21-5-6-24(28-15-21)36-20(4)13-19(3)34-36/h5-6,11-15,38H,7-10,16H2,1-4H3,(H,29,37)(H2,30,31,32,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367773
PNG
(US10227329, Compound 185)
Show SMILES COC1(CCN(CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N(C)Cc1ccc(nc1)-n1cccn1
Show InChI InChI=1S/C26H32N10O2/c1-18-14-21(30-22-15-19(2)32-33-22)31-25(29-18)35-12-8-26(38-4,9-13-35)24(37)34(3)17-20-6-7-23(27-16-20)36-11-5-10-28-36/h5-7,10-11,14-16H,8-9,12-13,17H2,1-4H3,(H2,29,30,31,32,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367725
PNG
(US10227329, Compound 137)
Show SMILES COC1(CN(C1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)NCc1ccc(nc1)-n1ccc(C)n1
Show InChI InChI=1S/C24H28N10O2/c1-15-7-8-34(32-15)21-6-5-18(11-25-21)12-26-22(35)24(36-4)13-33(14-24)23-27-16(2)9-19(29-23)28-20-10-17(3)30-31-20/h5-11H,12-14H2,1-4H3,(H,26,35)(H2,27,28,29,30,31)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367775
PNG
(US10227329, Compound 187)
Show SMILES C[C@H](N(C)C(=O)C1(O)CCN(CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cccn1
Show InChI InChI=1/C26H32N10O2/c1-17-14-21(30-22-15-18(2)32-33-22)31-25(29-17)35-12-8-26(38,9-13-35)24(37)34(4)19(3)20-6-7-23(27-16-20)36-11-5-10-28-36/h5-7,10-11,14-16,19,38H,8-9,12-13H2,1-4H3,(H2,29,30,31,32,33)/t19-/s2
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367776
PNG
(US10227329, Compound 188)
Show SMILES C[C@H](NC(=O)C1(C)CCN(CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1/C27H32FN9O/c1-17-11-22(32-23-13-18(2)34-35-23)33-25(12-17)36-9-7-27(4,8-10-36)26(38)31-19(3)20-5-6-24(29-14-20)37-16-21(28)15-30-37/h5-6,11-16,19H,7-10H2,1-4H3,(H,31,38)(H2,32,33,34,35)/t19-/s2
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367778
PNG
(US10227329, Compound 190)
Show SMILES CCC1(CCN(CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)NCc1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1S/C26H31FN10O/c1-4-26(24(38)29-14-19-5-6-23(28-13-19)37-16-20(27)15-30-37)7-9-36(10-8-26)25-31-17(2)11-21(33-25)32-22-12-18(3)34-35-22/h5-6,11-13,15-16H,4,7-10,14H2,1-3H3,(H,29,38)(H2,31,32,33,34,35)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367730
PNG
(US10227329, Compound 142)
Show SMILES C[C@H](N(C)C(=O)C1CN(C1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1/C24H27FN10O/c1-14-7-20(29-21-8-15(2)31-32-21)30-24(28-14)34-11-18(12-34)23(36)33(4)16(3)17-5-6-22(26-9-17)35-13-19(25)10-27-35/h5-10,13,16,18H,11-12H2,1-4H3,(H2,28,29,30,31,32)/t16-/s2
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367732
PNG
(US10227329, Compound 144)
Show SMILES C[C@H](NC(=O)[C@H]1CN([C@@H]1C)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1/C24H27FN10O/c1-13-7-20(30-21-8-14(2)32-33-21)31-24(28-13)34-12-19(16(34)4)23(36)29-15(3)17-5-6-22(26-9-17)35-11-18(25)10-27-35/h5-11,15-16,19H,12H2,1-4H3,(H,29,36)(H2,28,30,31,32,33)/t15-,16+,19-/s2
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367733
PNG
(US10227329, Compound 145)
Show SMILES C[C@H](NC(=O)C1(O)CN(C1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1/C24H26FN9O2/c1-14-6-19(29-20-8-15(2)31-32-20)30-22(7-14)33-12-24(36,13-33)23(35)28-16(3)17-4-5-21(26-9-17)34-11-18(25)10-27-34/h4-11,16,36H,12-13H2,1-3H3,(H,28,35)(H2,29,30,31,32)/t16-/s2
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US Patent
n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367786
PNG
(US10227329, Compound 198)
Show SMILES CO[C@]1(CN([C@@H]1C)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1/C25H29FN10O2/c1-14-8-20(31-21-9-15(2)33-34-21)32-24(29-14)35-13-25(38-5,17(35)4)23(37)30-16(3)18-6-7-22(27-10-18)36-12-19(26)11-28-36/h6-12,16-17H,13H2,1-5H3,(H,30,37)(H2,29,31,32,33,34)/t16-,17+,25-/s2
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367794
PNG
(US10227329, Compound 206)
Show SMILES C[C@H](NC(=O)C1(CC#N)CCN(CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cccn1
Show InChI InChI=1/C27H31N11O/c1-18-15-22(33-23-16-19(2)35-36-23)34-26(31-18)37-13-8-27(7-10-28,9-14-37)25(39)32-20(3)21-5-6-24(29-17-21)38-12-4-11-30-38/h4-6,11-12,15-17,20H,7-9,13-14H2,1-3H3,(H,32,39)(H2,31,33,34,35,36)/t20-/s2
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367796
PNG
(US10227329, Compound 208)
Show SMILES COC1(CN(C1)c1nc(Nc2cc(C)[nH]n2)cc(n1)C(F)F)C(=O)NCc1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1S/C23H23F3N10O2/c1-13-5-18(34-33-13)31-17-6-16(20(25)26)30-22(32-17)35-11-23(12-35,38-2)21(37)28-8-14-3-4-19(27-7-14)36-10-15(24)9-29-36/h3-7,9-10,20H,8,11-12H2,1-2H3,(H,28,37)(H2,30,31,32,33,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367747
PNG
(US10227329, Compound 159)
Show SMILES C[C@H](NC(=O)C1(CN(C1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C#N)c1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1/C24H24FN11O/c1-14-6-19(31-20-7-15(2)33-34-20)32-23(29-14)35-12-24(11-26,13-35)22(37)30-16(3)17-4-5-21(27-8-17)36-10-18(25)9-28-36/h4-10,16H,12-13H2,1-3H3,(H,30,37)(H2,29,31,32,33,34)/t16-/s2
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367748
PNG
(US10227329, Compound 160)
Show SMILES COC1(CCN(CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)NCc1ccc(nc1)-n1cccn1
Show InChI InChI=1S/C26H31N9O2/c1-18-13-21(30-22-15-19(2)32-33-22)31-24(14-18)34-11-7-26(37-3,8-12-34)25(36)28-17-20-5-6-23(27-16-20)35-10-4-9-29-35/h4-6,9-10,13-16H,7-8,11-12,17H2,1-3H3,(H,28,36)(H2,30,31,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367749
PNG
(US10227329, Compound 161)
Show SMILES COC1(CCN(CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)NCc1ccc(nc1)-n1cccn1
Show InChI InChI=1S/C25H30N10O2/c1-17-13-20(30-21-14-18(2)32-33-21)31-24(29-17)34-11-7-25(37-3,8-12-34)23(36)27-16-19-5-6-22(26-15-19)35-10-4-9-28-35/h4-6,9-10,13-15H,7-8,11-12,16H2,1-3H3,(H,27,36)(H2,29,30,31,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367801
PNG
(US10227329, Compound 213)
Show SMILES COCCC1(CCN(CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)NCc1ccc(nc1)-n1cccn1
Show InChI InChI=1S/C27H34N10O2/c1-19-15-22(32-23-16-20(2)34-35-23)33-26(31-19)36-12-7-27(8-13-36,9-14-39-3)25(38)29-18-21-5-6-24(28-17-21)37-11-4-10-30-37/h4-6,10-11,15-17H,7-9,12-14,18H2,1-3H3,(H,29,38)(H2,31,32,33,34,35)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367760
PNG
(US10227329, Compound 172)
Show SMILES COC1(CN(C1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)NCc1ccc(nc1)-n1cc(Cl)cn1
Show InChI InChI=1S/C23H25ClN10O2/c1-14-6-18(29-19-7-15(2)31-32-19)30-22(28-14)33-12-23(13-33,36-3)21(35)26-9-16-4-5-20(25-8-16)34-11-17(24)10-27-34/h4-8,10-11H,9,12-13H2,1-3H3,(H,26,35)(H2,28,29,30,31,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367810
PNG
(US10227329, Compound 222)
Show SMILES COC1(CCN(CC1)c1nc(Nc2cc(C)[nH]n2)cc(C)c1C#N)C(=O)N[C@@H](C)c1ccc(nc1)-n1cccn1
Show InChI InChI=1/C28H32N10O2/c1-18-14-23(33-24-15-19(2)35-36-24)34-26(22(18)16-29)37-12-8-28(40-4,9-13-37)27(39)32-20(3)21-6-7-25(30-17-21)38-11-5-10-31-38/h5-7,10-11,14-15,17,20H,8-9,12-13H2,1-4H3,(H,32,39)(H2,33,34,35,36)/t20-/s2
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367815
PNG
(US10227329, Compound 227)
Show SMILES COC1(CCN(CC1)c1nc(Nc2cc(C)[nH]n2)cc(C)c1C#N)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1/C28H31FN10O2/c1-17-11-23(34-24-12-18(2)36-37-24)35-26(22(17)13-30)38-9-7-28(41-4,8-10-38)27(40)33-19(3)20-5-6-25(31-14-20)39-16-21(29)15-32-39/h5-6,11-12,14-16,19H,7-10H2,1-4H3,(H,33,40)(H2,34,35,36,37)/t19-/s2
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367697
PNG
(US10227329, Compound 107)
Show SMILES Cc1cc(Nc2cc(C)cc(n2)N2CC(C)(C2)C(=O)NCc2ccc(nc2)-n2cccn2)n[nH]1
Show InChI InChI=1S/C24H27N9O/c1-16-9-19(28-20-11-17(2)30-31-20)29-22(10-16)32-14-24(3,15-32)23(34)26-13-18-5-6-21(25-12-18)33-8-4-7-27-33/h4-12H,13-15H2,1-3H3,(H,26,34)(H2,28,29,30,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367697
PNG
(US10227329, Compound 107)
Show SMILES Cc1cc(Nc2cc(C)cc(n2)N2CC(C)(C2)C(=O)NCc2ccc(nc2)-n2cccn2)n[nH]1
Show InChI InChI=1S/C24H27N9O/c1-16-9-19(28-20-11-17(2)30-31-20)29-22(10-16)32-14-24(3,15-32)23(34)26-13-18-5-6-21(25-12-18)33-8-4-7-27-33/h4-12H,13-15H2,1-3H3,(H,26,34)(H2,28,29,30,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367699
PNG
(US10227329, Compound 111)
Show SMILES Cc1cc(Nc2cc(C)cc(n2)N2CC(F)(C2)C(=O)NCc2ccc(nc2)-n2cccn2)n[nH]1
Show InChI InChI=1S/C23H24FN9O/c1-15-8-18(28-19-10-16(2)30-31-19)29-21(9-15)32-13-23(24,14-32)22(34)26-12-17-4-5-20(25-11-17)33-7-3-6-27-33/h3-11H,12-14H2,1-2H3,(H,26,34)(H2,28,29,30,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367709
PNG
(US10227329, Compound 121)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1/C23H25FN10O/c1-13-6-19(29-20-7-14(2)31-32-20)30-23(27-13)33-10-17(11-33)22(35)28-15(3)16-4-5-21(25-8-16)34-12-18(24)9-26-34/h4-9,12,15,17H,10-11H2,1-3H3,(H,28,35)(H2,27,29,30,31,32)/t15-/s2
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367712
PNG
(US10227329, Compound 124)
Show SMILES Cc1cc(Nc2cc(C)nc(n2)N2CC(F)(C2)C(=O)NCc2ccc(nc2)-n2cc(F)cn2)n[nH]1
Show InChI InChI=1S/C22H22F2N10O/c1-13-5-17(29-18-6-14(2)31-32-18)30-21(28-13)33-11-22(24,12-33)20(35)26-8-15-3-4-19(25-7-15)34-10-16(23)9-27-34/h3-7,9-10H,8,11-12H2,1-2H3,(H,26,35)(H2,28,29,30,31,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367717
PNG
(US10227329, Compound 129)
Show SMILES Cc1cc(Nc2cc(C)nc(n2)N2CCC(C)(CC2)C(=O)NCc2ccc(nc2)-n2cccn2)n[nH]1
Show InChI InChI=1S/C25H30N10O/c1-17-13-20(30-21-14-18(2)32-33-21)31-24(29-17)34-11-7-25(3,8-12-34)23(36)27-16-19-5-6-22(26-15-19)35-10-4-9-28-35/h4-6,9-10,13-15H,7-8,11-12,16H2,1-3H3,(H,27,36)(H2,29,30,31,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367768
PNG
(US10227329, Compound 180)
Show SMILES Cc1cc(Nc2cc(cc(n2)N2CC(F)(C2)C(=O)NCc2ccc(nc2)-n2cc(F)cn2)C(F)F)n[nH]1
Show InChI InChI=1S/C23H21F4N9O/c1-13-4-18(34-33-13)31-17-5-15(21(25)26)6-20(32-17)35-11-23(27,12-35)22(37)29-8-14-2-3-19(28-7-14)36-10-16(24)9-30-36/h2-7,9-10,21H,8,11-12H2,1H3,(H,29,37)(H2,31,32,33,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367768
PNG
(US10227329, Compound 180)
Show SMILES Cc1cc(Nc2cc(cc(n2)N2CC(F)(C2)C(=O)NCc2ccc(nc2)-n2cc(F)cn2)C(F)F)n[nH]1
Show InChI InChI=1S/C23H21F4N9O/c1-13-4-18(34-33-13)31-17-5-15(21(25)26)6-20(32-17)35-11-23(27,12-35)22(37)29-8-14-2-3-19(28-7-14)36-10-16(24)9-30-36/h2-7,9-10,21H,8,11-12H2,1H3,(H,29,37)(H2,31,32,33,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367719
PNG
(US10227329, Compound 131)
Show SMILES Cc1cc(Nc2cc(C)cc(n2)N2CCC(O)(CC2)C(=O)NCc2ccc(nc2)-n2cccn2)n[nH]1
Show InChI InChI=1S/C25H29N9O2/c1-17-12-20(29-21-14-18(2)31-32-21)30-23(13-17)33-10-6-25(36,7-11-33)24(35)27-16-19-4-5-22(26-15-19)34-9-3-8-28-34/h3-5,8-9,12-15,36H,6-7,10-11,16H2,1-2H3,(H,27,35)(H2,29,30,31,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367772
PNG
(US10227329, Compound 184)
Show SMILES COC1(CN(C1)c1nc(Nc2cc(C)[nH]n2)cc(C)c1C#N)C(=O)NCc1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1S/C25H25FN10O2/c1-15-6-20(31-21-7-16(2)33-34-21)32-23(19(15)8-27)35-13-25(14-35,38-3)24(37)29-10-17-4-5-22(28-9-17)36-12-18(26)11-30-36/h4-7,9,11-12H,10,13-14H2,1-3H3,(H,29,37)(H2,31,32,33,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367773
PNG
(US10227329, Compound 185)
Show SMILES COC1(CCN(CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N(C)Cc1ccc(nc1)-n1cccn1
Show InChI InChI=1S/C26H32N10O2/c1-18-14-21(30-22-15-19(2)32-33-22)31-25(29-18)35-12-8-26(38-4,9-13-35)24(37)34(3)17-20-6-7-23(27-16-20)36-11-5-10-28-36/h5-7,10-11,14-16H,8-9,12-13,17H2,1-4H3,(H2,29,30,31,32,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367724
PNG
(US10227329, Compound 136)
Show SMILES Cc1cc(Nc2cc(C)nc(n2)N2CCC(O)(CC2)C(=O)NCc2ccc(nc2)-n2cccn2)n[nH]1
Show InChI InChI=1S/C24H28N10O2/c1-16-12-19(29-20-13-17(2)31-32-20)30-23(28-16)33-10-6-24(36,7-11-33)22(35)26-15-18-4-5-21(25-14-18)34-9-3-8-27-34/h3-5,8-9,12-14,36H,6-7,10-11,15H2,1-2H3,(H,26,35)(H2,28,29,30,31,32)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367727
PNG
(US10227329, Compound 139)
Show SMILES C[C@H](NC(=O)C1(C)CN(C1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1/C25H28FN9O/c1-15-7-20(30-21-9-16(2)32-33-21)31-23(8-15)34-13-25(4,14-34)24(36)29-17(3)18-5-6-22(27-10-18)35-12-19(26)11-28-35/h5-12,17H,13-14H2,1-4H3,(H,29,36)(H2,30,31,32,33)/t17-/s2
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367776
PNG
(US10227329, Compound 188)
Show SMILES C[C@H](NC(=O)C1(C)CCN(CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1/C27H32FN9O/c1-17-11-22(32-23-13-18(2)34-35-23)33-25(12-17)36-9-7-27(4,8-10-36)26(38)31-19(3)20-5-6-24(29-14-20)37-16-21(28)15-30-37/h5-6,11-16,19H,7-10H2,1-4H3,(H,31,38)(H2,32,33,34,35)/t19-/s2
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367777
PNG
(US10227329, Compound 189)
Show SMILES C[C@H](NC(=O)C1(F)CN(C1)c1nc(Nc2cc(C)[nH]n2)cc(C)c1C#N)c1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1/C25H24F2N10O/c1-14-6-20(32-21-7-15(2)34-35-21)33-23(19(14)8-28)36-12-25(27,13-36)24(38)31-16(3)17-4-5-22(29-9-17)37-11-18(26)10-30-37/h4-7,9-11,16H,12-13H2,1-3H3,(H,31,38)(H2,32,33,34,35)/t16-/s2
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367729
PNG
(US10227329, Compound 141)
Show SMILES Cc1cc(Nc2cc(C)nc(n2)N2CCC(F)(CC2)C(=O)NCc2ccc(nc2)-n2cccn2)n[nH]1
Show InChI InChI=1S/C24H27FN10O/c1-16-12-19(30-20-13-17(2)32-33-20)31-23(29-16)34-10-6-24(25,7-11-34)22(36)27-15-18-4-5-21(26-14-18)35-9-3-8-28-35/h3-5,8-9,12-14H,6-7,10-11,15H2,1-2H3,(H,27,36)(H2,29,30,31,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367736
PNG
(US10227329, Compound 148)
Show SMILES COC1(CN(C1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)NCc1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1S/C23H25FN10O2/c1-14-6-18(29-19-7-15(2)31-32-19)30-22(28-14)33-12-23(13-33,36-3)21(35)26-9-16-4-5-20(25-8-16)34-11-17(24)10-27-34/h4-8,10-11H,9,12-13H2,1-3H3,(H,26,35)(H2,28,29,30,31,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367790
PNG
(US10227329, Compound 202)
Show SMILES COC1(CN(C1)c1nc(Nc2cc(C)[nH]n2)cc(C)c1F)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1/C25H27F2N9O2/c1-14-7-19(31-20-8-15(2)33-34-20)32-23(22(14)27)35-12-25(13-35,38-4)24(37)30-16(3)17-5-6-21(28-9-17)36-11-18(26)10-29-36/h5-11,16H,12-13H2,1-4H3,(H,30,37)(H2,31,32,33,34)/t16-/s2
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367790
PNG
(US10227329, Compound 202)
Show SMILES COC1(CN(C1)c1nc(Nc2cc(C)[nH]n2)cc(C)c1F)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1
Show InChI InChI=1/C25H27F2N9O2/c1-14-7-19(31-20-8-15(2)33-34-20)32-23(22(14)27)35-12-25(13-35,38-4)24(37)30-16(3)17-5-6-21(28-9-17)36-11-18(26)10-29-36/h5-11,16H,12-13H2,1-4H3,(H,30,37)(H2,31,32,33,34)/t16-/s2
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367792
PNG
(US10227329, Compound 204)
Show SMILES COC1(CN(C1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)NCc1ccc(nc1)-n1ccc(n1)C(F)F
Show InChI InChI=1S/C24H26F2N10O2/c1-14-8-18(30-19-9-15(2)32-33-19)31-23(29-14)35-12-24(13-35,38-3)22(37)28-11-16-4-5-20(27-10-16)36-7-6-17(34-36)21(25)26/h4-10,21H,11-13H2,1-3H3,(H,28,37)(H2,29,30,31,32,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM367744
PNG
(US10227329, Compound 156)
Show SMILES COC1(CN(C1)c1nc(Nc2cc(C)[nH]n2)cc(C)c1C#N)C(=O)NCc1ccc(nc1)-n1cccn1
Show InChI InChI=1S/C25H26N10O2/c1-16-9-20(30-21-10-17(2)32-33-21)31-23(19(16)11-26)34-14-25(15-34,37-3)24(36)28-13-18-5-6-22(27-12-18)35-8-4-7-29-35/h4-10,12H,13-15H2,1-3H3,(H,28,36)(H2,30,31,32,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM367795
PNG
(US10227329, Compound 207)
Show SMILES COC1(CCN(CC1)c1nc(Nc2cc(C)[nH]n2)cc(C)c1C#N)C(=O)NCc1ccc(nc1)-n1cccn1
Show InChI InChI=1S/C27H30N10O2/c1-18-13-22(32-23-14-19(2)34-35-23)33-25(21(18)15-28)36-11-7-27(39-3,8-12-36)26(38)30-17-20-5-6-24(29-16-20)37-10-4-9-31-37/h4-6,9-10,13-14,16H,7-8,11-12,17H2,1-3H3,(H,30,38)(H2,32,33,34,35)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...


US Patent US10227329 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%