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Patent code US10227338

Compile Data Set for Download or QSAR
Found 181 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368342
PNG
(US10227338, Example 129)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(Cl)s1
Show InChI InChI=1S/C19H20Cl2FN5O2S2/c1-23-7-8-27(2)16-6-4-3-5-14(16)25-15-10-13(22)17(9-12(15)20)31(28,29)26-19-24-11-18(21)30-19/h3-6,9-11,23,25H,7-8H2,1-2H3,(H,24,26)
PDB

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n/an/a 4n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368343
PNG
(US10227338, Example 130)
Show SMILES CNCCN(C)c1cc(OC)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(Cl)s1
Show InChI InChI=1S/C20H22Cl2FN5O3S2/c1-24-6-7-28(2)17-8-12(31-3)4-5-15(17)26-16-10-14(23)18(9-13(16)21)33(29,30)27-20-25-11-19(22)32-20/h4-5,8-11,24,26H,6-7H2,1-3H3,(H,25,27)
PDB

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n/an/a 6n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368340
PNG
(US10227338, Example 127)
Show SMILES CNCCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(Cl)s1
Show InChI InChI=1S/C19H19Cl2F2N5O2S2/c1-24-5-6-28(2)16-7-11(22)3-4-14(16)26-15-9-13(23)17(8-12(15)20)32(29,30)27-19-25-10-18(21)31-19/h3-4,7-10,24,26H,5-6H2,1-2H3,(H,25,27)
PDB

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n/an/a 8n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368341
PNG
(US10227338, Example 128)
Show SMILES CNCCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)s1
Show InChI InChI=1S/C19H19ClF3N5O2S2/c1-24-5-6-28(2)16-7-11(21)3-4-14(16)26-15-9-13(22)17(8-12(15)20)32(29,30)27-19-25-10-18(23)31-19/h3-4,7-10,24,26H,5-6H2,1-2H3,(H,25,27)
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368324
PNG
(US10227338, Example 111)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C20H20ClF4N5O2S2/c1-26-5-7-30(2)17-9-12(20(23,24)25)3-4-15(17)28-16-11-14(22)18(10-13(16)21)34(31,32)29-19-27-6-8-33-19/h3-4,6,8-11,26,28H,5,7H2,1-2H3,(H,27,29)
PDB

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n/an/a 10n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368272
PNG
(US10227338, Example 55)
Show SMILES CNC1CCN(C1)c1cc(OC)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H23ClFN5O3S2/c1-24-13-5-6-28(10-13)19-7-14(31-2)3-4-17(19)26-18-9-16(23)20(8-15(18)22)33(29,30)27-21-11-32-12-25-21/h3-4,7-9,11-13,24,26-27H,5-6,10H2,1-2H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368258
PNG
(US10227338, Example 40 | US10227338, Example 50)
Show SMILES CNC1CCN(C1)c1ccccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H22ClN5O2S2/c1-22-14-8-9-26(11-14)19-5-3-2-4-18(19)24-17-7-6-15(10-16(17)21)30(27,28)25-20-12-29-13-23-20/h2-7,10,12-14,22,24-25H,8-9,11H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368220
PNG
(US10227338, Example 1 | US10227338, Example 32)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20ClF2N5O2S2/c1-24-13-4-5-28(9-13)18-6-12(22)2-3-16(18)26-17-8-15(23)19(7-14(17)21)32(29,30)27-20-10-31-11-25-20/h2-3,6-8,10-11,13,24,26-27H,4-5,9H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368339
PNG
(US10227338, Example 126)
Show SMILES CNCCN(C)c1cc(Cl)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H20Cl2FN5O2S2/c1-23-5-7-27(2)17-9-12(20)3-4-15(17)25-16-11-14(22)18(10-13(16)21)31(28,29)26-19-24-6-8-30-19/h3-4,6,8-11,23,25H,5,7H2,1-2H3,(H,24,26)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368318
PNG
(US10227338, Example 105)
Show SMILES CNCCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H20ClF2N5O2S2/c1-23-5-7-27(2)17-9-12(21)3-4-15(17)25-16-11-14(22)18(10-13(16)20)31(28,29)26-19-24-6-8-30-19/h3-4,6,8-11,23,25H,5,7H2,1-2H3,(H,24,26)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368332
PNG
(US10227338, Example 119)
Show SMILES CNCCN(C)c1cc(OC)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H23ClFN5O3S2/c1-23-6-8-27(2)18-10-13(30-3)4-5-16(18)25-17-12-15(22)19(11-14(17)21)32(28,29)26-20-24-7-9-31-20/h4-5,7,9-12,23,25H,6,8H2,1-3H3,(H,24,26)
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368347
PNG
(US10227338, Example 134)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cc(C)on1
Show InChI InChI=1S/C20H23ClFN5O3S/c1-13-10-20(25-30-13)26-31(28,29)19-11-14(21)17(12-15(19)22)24-16-6-4-5-7-18(16)27(3)9-8-23-2/h4-7,10-12,23-24H,8-9H2,1-3H3,(H,25,26)
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368321
PNG
(US10227338, Example 108)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)C#N
Show InChI InChI=1S/C20H20ClFN6O2S2/c1-24-5-7-28(2)18-9-13(12-23)3-4-16(18)26-17-11-15(22)19(10-14(17)21)32(29,30)27-20-25-6-8-31-20/h3-4,6,8-11,24,26H,5,7H2,1-2H3,(H,25,27)
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368327
PNG
(US10227338, Example 114 | US10227338, Example 116)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H21ClFN5O2S2/c1-22-7-9-26(2)17-6-4-3-5-15(17)24-16-12-14(21)18(11-13(16)20)30(27,28)25-19-23-8-10-29-19/h3-6,8,10-12,22,24H,7,9H2,1-2H3,(H,23,25)
PDB

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n/an/a 20n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368239
PNG
(US10227338, Example 20)
Show SMILES CNC1CCN(C1)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1/C21H20ClF4N5O2S2/c1-27-13-4-5-31(9-13)18-6-12(21(24,25)26)2-3-16(18)29-17-8-15(23)19(7-14(17)22)35(32,33)30-20-10-34-11-28-20/h2-3,6-8,10-11,13,27,29-30H,4-5,9H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368298
PNG
(US10227338, Example 81)
Show SMILES CN[C@H]1CCN(C1)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1/C21H20ClF4N5O2S2/c1-27-13-4-5-31(9-13)18-6-12(21(24,25)26)2-3-16(18)29-17-8-15(23)19(7-14(17)22)35(32,33)30-20-10-34-11-28-20/h2-3,6-8,10-11,13,27,29-30H,4-5,9H2,1H3/t13-/s2
PDB

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n/an/a 23n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368221
PNG
(US10227338, Example 2)
Show SMILES CNC1CCN(C1)c1cc(Cl)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20Cl2FN5O2S2/c1-24-13-4-5-28(9-13)18-6-12(21)2-3-16(18)26-17-8-15(23)19(7-14(17)22)32(29,30)27-20-10-31-11-25-20/h2-3,6-8,10-11,13,24,26-27H,4-5,9H2,1H3
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368256
PNG
(US10227338, Example 38)
Show SMILES CNC1CCN(C1)c1cc(ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1/C21H21ClF3N5O2S2/c1-26-14-6-7-30(10-14)19-8-13(21(23,24)25)2-4-18(19)28-17-5-3-15(9-16(17)22)34(31,32)29-20-11-33-12-27-20/h2-5,8-9,11-12,14,26,28-29H,6-7,10H2,1H3
PDB

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n/an/a 27n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368344
PNG
(US10227338, Example 131)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)s1
Show InChI InChI=1S/C19H20ClF2N5O2S2/c1-23-7-8-27(2)16-6-4-3-5-14(16)25-15-10-13(21)17(9-12(15)20)31(28,29)26-19-24-11-18(22)30-19/h3-6,9-11,23,25H,7-8H2,1-2H3,(H,24,26)
PDB

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n/an/a 27n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368297
PNG
(US10227338, Example 80)
Show SMILES CN[C@H]1CCN(C1)c1cc(ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1/C21H21ClF3N5O2S2/c1-26-14-6-7-30(10-14)19-8-13(21(23,24)25)2-4-18(19)28-17-5-3-15(9-16(17)22)34(31,32)29-20-11-33-12-27-20/h2-5,8-9,11-12,14,26,28-29H,6-7,10H2,1H3/t14-/s2
PDB

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n/an/a 28n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368284
PNG
(US10227338, Example 67)
Show SMILES CN1CCN(CC1)c1cc(OC(F)(F)F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H20ClF4N5O3S2/c1-30-4-6-31(7-5-30)18-8-13(34-21(24,25)26)2-3-16(18)28-17-10-15(23)19(9-14(17)22)36(32,33)29-20-11-35-12-27-20/h2-3,8-12,28-29H,4-7H2,1H3
PDB

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n/an/a 28n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368308
PNG
(US10227338, Example 95)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1S/C20H20ClF4N5O2S2/c1-26-5-6-30(2)17-7-12(20(23,24)25)3-4-15(17)28-16-9-14(22)18(8-13(16)21)34(31,32)29-19-10-33-11-27-19/h3-4,7-11,26,28-29H,5-6H2,1-2H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368294
PNG
(US10227338, Example 77)
Show SMILES CNC1CCN(C1)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)C#N
Show InChI InChI=1/C21H20ClFN6O2S2/c1-25-14-4-5-29(10-14)19-6-13(9-24)2-3-17(19)27-18-8-16(23)20(7-15(18)22)33(30,31)28-21-11-32-12-26-21/h2-3,6-8,11-12,14,25,27-28H,4-5,10H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368220
PNG
(US10227338, Example 1 | US10227338, Example 32)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20ClF2N5O2S2/c1-24-13-4-5-28(9-13)18-6-12(22)2-3-16(18)26-17-8-15(23)19(7-14(17)21)32(29,30)27-20-10-31-11-25-20/h2-3,6-8,10-11,13,24,26-27H,4-5,9H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368316
PNG
(US10227338, Example 103)
Show SMILES CN(CCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)N(C(=O)OC(C)(C)C)c1ccc(F)cn1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C31H37ClF3N5O6S/c1-30(2,3)45-28(41)39(8)14-13-38(7)25-15-19(33)9-11-23(25)37-24-17-22(35)26(16-21(24)32)47(43,44)40(29(42)46-31(4,5)6)27-12-10-20(34)18-36-27/h9-12,15-18,37H,13-14H2,1-8H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368311
PNG
(US10227338, Example 121 | US10227338, Example 98)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C19H21ClFN5O2S2/c1-22-7-8-26(2)17-6-4-3-5-15(17)24-16-10-14(21)18(9-13(16)20)30(27,28)25-19-11-29-12-23-19/h3-6,9-12,22,24-25H,7-8H2,1-2H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368305
PNG
(US10227338, Example 92)
Show SMILES CN(CCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)N(C(=O)OC(C)(C)C)c1cscn1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H36ClF2N5O6S2/c1-28(2,3)42-26(38)36(8)12-11-35(7)23-13-18(31)9-10-21(23)34-22-15-20(32)24(14-19(22)30)45(40,41)37(25-16-44-17-33-25)27(39)43-29(4,5)6/h9-10,13-17,34H,11-12H2,1-8H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368249
PNG
(US10227338, Example 31)
Show SMILES CN[C@@H]1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20ClF2N5O2S2/c1-24-13-4-5-28(9-13)18-6-12(22)2-3-16(18)26-17-8-15(23)19(7-14(17)21)32(29,30)27-20-10-31-11-25-20/h2-3,6-8,10-11,13,24,26-27H,4-5,9H2,1H3/t13-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368223
PNG
(US10227338, Example 4)
Show SMILES CN[C@@H]1CCCN(C1)c1cc(Cl)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H22Cl2FN5O2S2/c1-25-14-3-2-6-29(10-14)19-7-13(22)4-5-17(19)27-18-9-16(24)20(8-15(18)23)33(30,31)28-21-11-32-12-26-21/h4-5,7-9,11-12,14,25,27-28H,2-3,6,10H2,1H3/t14-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368289
PNG
(US10227338, Example 72)
Show SMILES CN(C)[C@H]1CCN(C1)c1cc(OC(F)F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H23ClF3N5O3S2/c1-30(2)13-5-6-31(10-13)19-7-14(34-22(25)26)3-4-17(19)28-18-9-16(24)20(8-15(18)23)36(32,33)29-21-11-35-12-27-21/h3-4,7-9,11-13,22,28-29H,5-6,10H2,1-2H3/t13-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368243
PNG
(US10227338, Example 24)
Show SMILES CN[C@@H]1CCCN(C1)c1cc(F)ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H23ClFN5O2S2/c1-24-15-3-2-8-28(11-15)20-9-14(23)4-6-19(20)26-18-7-5-16(10-17(18)22)32(29,30)27-21-12-31-13-25-21/h4-7,9-10,12-13,15,24,26-27H,2-3,8,11H2,1H3/t15-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368354
PNG
(US10227338, Example 141)
Show SMILES CNCCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(C)s1
Show InChI InChI=1S/C20H22ClF2N5O2S2/c1-12-11-25-20(31-12)27-32(29,30)19-9-14(21)17(10-15(19)23)26-16-5-4-13(22)8-18(16)28(3)7-6-24-2/h4-5,8-11,24,26H,6-7H2,1-3H3,(H,25,27)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368336
PNG
(US10227338, Example 123)
Show SMILES CNCCN(C)c1cc(Cl)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C19H20Cl2FN5O2S2/c1-23-5-6-27(2)17-7-12(20)3-4-15(17)25-16-9-14(22)18(8-13(16)21)31(28,29)26-19-10-30-11-24-19/h3-4,7-11,23,25-26H,5-6H2,1-2H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368287
PNG
(US10227338, Example 70)
Show SMILES CN[C@H]1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20ClF2N5O2S2/c1-24-13-4-5-28(9-13)18-6-12(22)2-3-16(18)26-17-8-15(23)19(7-14(17)21)32(29,30)27-20-10-31-11-25-20/h2-3,6-8,10-11,13,24,26-27H,4-5,9H2,1H3/t13-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368327
PNG
(US10227338, Example 114 | US10227338, Example 116)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H21ClFN5O2S2/c1-22-7-9-26(2)17-6-4-3-5-15(17)24-16-12-14(21)18(11-13(16)20)30(27,28)25-19-23-8-10-29-19/h3-6,8,10-12,22,24H,7,9H2,1-2H3,(H,23,25)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368322
PNG
(US10227338, Example 109)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccc(F)cn1)C(F)(F)F
Show InChI InChI=1S/C22H21ClF5N5O2S/c1-29-7-8-33(2)19-9-13(22(26,27)28)3-5-17(19)31-18-11-16(25)20(10-15(18)23)36(34,35)32-21-6-4-14(24)12-30-21/h3-6,9-12,29,31H,7-8H2,1-2H3,(H,30,32)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368254
PNG
(US10227338, Example 36)
Show SMILES CNC1CCN(C1)c1ccccc1Nc1ccc(cc1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H23N5O2S2/c1-21-16-10-11-25(12-16)19-5-3-2-4-18(19)23-15-6-8-17(9-7-15)29(26,27)24-20-13-28-14-22-20/h2-9,13-14,16,21,23-24H,10-12H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368257
PNG
(US10227338, Example 39 | US10227338, Example 49)
Show SMILES CNC1CCN(C1)c1ccccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H22FN5O2S2/c1-22-15-8-9-26(11-15)18-5-3-2-4-17(18)24-14-6-7-19(16(21)10-14)30(27,28)25-20-12-29-13-23-20/h2-7,10,12-13,15,22,24-25H,8-9,11H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368236
PNG
(US10227338, Example 17)
Show SMILES CNC1CCN(C1)c1cc(OC(F)(F)F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H20ClF4N5O3S2/c1-27-12-4-5-31(9-12)18-6-13(34-21(24,25)26)2-3-16(18)29-17-8-15(23)19(7-14(17)22)36(32,33)30-20-10-35-11-28-20/h2-3,6-8,10-12,27,29-30H,4-5,9H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368255
PNG
(US10227338, Example 37)
Show SMILES CNC1CCN(C1)c1cc(ccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1/C21H21F4N5O2S2/c1-26-15-6-7-30(10-15)18-8-13(21(23,24)25)2-4-17(18)28-14-3-5-19(16(22)9-14)34(31,32)29-20-11-33-12-27-20/h2-5,8-9,11-12,15,26,28-29H,6-7,10H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368352
PNG
(US10227338, Example 139)
Show SMILES CN(C)CCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(Cl)s1
Show InChI InChI=1S/C20H21Cl2F2N5O2S2/c1-28(2)6-7-29(3)17-8-12(23)4-5-15(17)26-16-10-14(24)18(9-13(16)21)33(30,31)27-20-25-11-19(22)32-20/h4-5,8-11,26H,6-7H2,1-3H3,(H,25,27)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368311
PNG
(US10227338, Example 121 | US10227338, Example 98)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C19H21ClFN5O2S2/c1-22-7-8-26(2)17-6-4-3-5-15(17)24-16-10-14(21)18(9-13(16)20)30(27,28)25-19-11-29-12-23-19/h3-6,9-12,22,24-25H,7-8H2,1-2H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368310
PNG
(US10227338, Example 97)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)cn1)C(F)(F)F
Show InChI InChI=1S/C21H20ClF5N6O2S/c1-28-5-6-33(2)18-7-12(21(25,26)27)3-4-16(18)31-17-9-15(24)19(8-14(17)22)36(34,35)32-20-29-10-13(23)11-30-20/h3-4,7-11,28,31H,5-6H2,1-2H3,(H,29,30,32)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368240
PNG
(US10227338, Example 21 | US10227338, Example 52)
Show SMILES CNC1CCN(C1)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H21ClFN5O2S2/c1-23-13-6-7-27(10-13)18-5-3-2-4-16(18)25-17-9-15(22)19(8-14(17)21)31(28,29)26-20-11-30-12-24-20/h2-5,8-9,11-13,23,25-26H,6-7,10H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368240
PNG
(US10227338, Example 21 | US10227338, Example 52)
Show SMILES CNC1CCN(C1)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H21ClFN5O2S2/c1-23-13-6-7-27(10-13)18-5-3-2-4-16(18)25-17-9-15(22)19(8-14(17)21)31(28,29)26-20-11-30-12-24-20/h2-5,8-9,11-13,23,25-26H,6-7,10H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368244
PNG
(US10227338, Example 26)
Show SMILES CN[C@@H]1CCCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H22ClF2N5O2S2/c1-25-14-3-2-6-29(10-14)19-7-13(23)4-5-17(19)27-18-9-16(24)20(8-15(18)22)33(30,31)28-21-11-32-12-26-21/h4-5,7-9,11-12,14,25,27-28H,2-3,6,10H2,1H3/t14-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368325
PNG
(US10227338, Example 112 | US10227338, Example 115)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C21H22ClF2N5O2S/c1-25-9-10-29(2)19-6-4-3-5-17(19)27-18-12-16(24)20(11-15(18)22)32(30,31)28-21-8-7-14(23)13-26-21/h3-8,11-13,25,27H,9-10H2,1-2H3,(H,26,28)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368323
PNG
(US10227338, Example 110)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccccn1)C(F)(F)F
Show InChI InChI=1S/C22H22ClF4N5O2S/c1-28-9-10-32(2)19-11-14(22(25,26)27)6-7-17(19)30-18-13-16(24)20(12-15(18)23)35(33,34)31-21-5-3-4-8-29-21/h3-8,11-13,28,30H,9-10H2,1-2H3,(H,29,31)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368277
PNG
(US10227338, Example 60)
Show SMILES CN[C@@H]1CCCN(C1)c1cc(OC)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H25ClFN5O3S2/c1-25-14-4-3-7-29(11-14)20-8-15(32-2)5-6-18(20)27-19-10-17(24)21(9-16(19)23)34(30,31)28-22-12-33-13-26-22/h5-6,8-10,12-14,25,27-28H,3-4,7,11H2,1-2H3/t14-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368338
PNG
(US10227338, Example 125)
Show SMILES CNCCN(C)c1cc(Cl)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C21H21Cl2F2N5O2S/c1-26-7-8-30(2)19-9-13(22)3-5-17(19)28-18-11-16(25)20(10-15(18)23)33(31,32)29-21-6-4-14(24)12-27-21/h3-6,9-12,26,28H,7-8H2,1-2H3,(H,27,29)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368309
PNG
(US10227338, Example 96)
Show SMILES CN(CCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)N(C(=O)OC(C)(C)C)c1ncc(F)cn1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H36ClF3N6O6S/c1-29(2,3)45-27(41)39(8)12-11-38(7)24-13-18(32)9-10-22(24)37-23-15-21(34)25(14-20(23)31)47(43,44)40(28(42)46-30(4,5)6)26-35-16-19(33)17-36-26/h9-10,13-17,37H,11-12H2,1-8H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368266
PNG
(US10227338, Example 48)
Show SMILES CNC1CCN(C1)c1c(F)cccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20ClF2N5O2S2/c1-24-12-5-6-28(9-12)20-14(22)3-2-4-16(20)26-17-8-15(23)18(7-13(17)21)32(29,30)27-19-10-31-11-25-19/h2-4,7-8,10-12,24,26-27H,5-6,9H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368290
PNG
(US10227338, Example 73)
Show SMILES CN(C)[C@@H]1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H22ClF2N5O2S2/c1-28(2)14-5-6-29(10-14)19-7-13(23)3-4-17(19)26-18-9-16(24)20(8-15(18)22)33(30,31)27-21-11-32-12-25-21/h3-4,7-9,11-12,14,26-27H,5-6,10H2,1-2H3/t14-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368314
PNG
(US10227338, Example 101 | US10227338, Example 102)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)cn1
Show InChI InChI=1S/C20H21ClF2N6O2S/c1-24-7-8-29(2)18-6-4-3-5-16(18)27-17-10-15(23)19(9-14(17)21)32(30,31)28-20-25-11-13(22)12-26-20/h3-6,9-12,24,27H,7-8H2,1-2H3,(H,25,26,28)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368307
PNG
(US10227338, Example 94)
Show SMILES CN(C)CCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C20H22ClF2N5O2S2/c1-27(2)6-7-28(3)18-8-13(22)4-5-16(18)25-17-10-15(23)19(9-14(17)21)32(29,30)26-20-11-31-12-24-20/h4-5,8-12,25-26H,6-7H2,1-3H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368222
PNG
(US10227338, Example 3)
Show SMILES C[C@@H]1CNCCN1c1cc(Cl)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20Cl2FN5O2S2/c1-12-9-24-4-5-28(12)18-6-13(21)2-3-16(18)26-17-8-15(23)19(7-14(17)22)32(29,30)27-20-10-31-11-25-20/h2-3,6-8,10-12,24,26-27H,4-5,9H2,1H3/t12-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368285
PNG
(US10227338, Example 68)
Show SMILES CN(C)[C@H]1CCN(C1)c1cc(ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1/C22H23ClF3N5O2S2/c1-30(2)15-7-8-31(11-15)20-9-14(22(24,25)26)3-5-19(20)28-18-6-4-16(10-17(18)23)35(32,33)29-21-12-34-13-27-21/h3-6,9-10,12-13,15,28-29H,7-8,11H2,1-2H3/t15-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368235
PNG
(US10227338, Example 16)
Show SMILES CNC1CCN(C1)c1cc(OC(F)(F)F)ccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H21F4N5O3S2/c1-26-14-6-7-30(10-14)18-9-15(33-21(23,24)25)3-4-17(18)28-13-2-5-19(16(22)8-13)35(31,32)29-20-11-34-12-27-20/h2-5,8-9,11-12,14,26,28-29H,6-7,10H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368317
PNG
(US10227338, Example 104)
Show SMILES CNCCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccccn1
Show InChI InChI=1S/C21H22ClF2N5O2S/c1-25-9-10-29(2)19-11-14(23)6-7-17(19)27-18-13-16(24)20(12-15(18)22)32(30,31)28-21-5-3-4-8-26-21/h3-8,11-13,25,27H,9-10H2,1-2H3,(H,26,28)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368314
PNG
(US10227338, Example 101 | US10227338, Example 102)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)cn1
Show InChI InChI=1S/C20H21ClF2N6O2S/c1-24-7-8-29(2)18-6-4-3-5-16(18)27-17-10-15(23)19(9-14(17)21)32(30,31)28-20-25-11-13(22)12-26-20/h3-6,9-12,24,27H,7-8H2,1-2H3,(H,25,26,28)
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368361
PNG
(US10227338, Example 148)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)cn1
Show InChI InChI=1/C21H20ClF3N6O2S/c1-26-14-4-5-31(11-14)19-6-12(23)2-3-17(19)29-18-8-16(25)20(7-15(18)22)34(32,33)30-21-27-9-13(24)10-28-21/h2-3,6-10,14,26,29H,4-5,11H2,1H3,(H,27,28,30)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368312
PNG
(US10227338, Example 99)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)C#N
Show InChI InChI=1S/C20H20ClFN6O2S2/c1-24-5-6-28(2)18-7-13(10-23)3-4-16(18)26-17-9-15(22)19(8-14(17)21)32(29,30)27-20-11-31-12-25-20/h3-4,7-9,11-12,24,26-27H,5-6H2,1-2H3
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368224
PNG
(US10227338, Example 5)
Show SMILES CC(=O)N[C@@H]1CCN(C1)c1cc(Cl)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H20Cl2FN5O3S2/c1-12(30)26-14-4-5-29(9-14)19-6-13(22)2-3-17(19)27-18-8-16(24)20(7-15(18)23)34(31,32)28-21-10-33-11-25-21/h2-3,6-8,10-11,14,27-28H,4-5,9H2,1H3,(H,26,30)/t14-/s2
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368326
PNG
(US10227338, Example 113 | US10227338, Example 117)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccccn1
Show InChI InChI=1S/C21H23ClFN5O2S/c1-24-11-12-28(2)19-8-4-3-7-17(19)26-18-14-16(23)20(13-15(18)22)31(29,30)27-21-9-5-6-10-25-21/h3-10,13-14,24,26H,11-12H2,1-2H3,(H,25,27)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368337
PNG
(US10227338, Example 124)
Show SMILES CNCCN(C)c1cc(Cl)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)cn1
Show InChI InChI=1S/C20H20Cl2F2N6O2S/c1-25-5-6-30(2)18-7-12(21)3-4-16(18)28-17-9-15(24)19(8-14(17)22)33(31,32)29-20-26-10-13(23)11-27-20/h3-4,7-11,25,28H,5-6H2,1-2H3,(H,26,27,29)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368226
PNG
(US10227338, Example 7)
Show SMILES Fc1cc(Nc2ccc(Cl)cc2N2CCC(C2)N2CCCC2)c(Cl)cc1S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C23H24Cl2FN5O2S2/c24-15-3-4-19(21(9-15)31-8-5-16(12-31)30-6-1-2-7-30)28-20-11-18(26)22(10-17(20)25)35(32,33)29-23-13-34-14-27-23/h3-4,9-11,13-14,16,28-29H,1-2,5-8,12H2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368292
PNG
(US10227338, Example 75)
Show SMILES CN(C)[C@@H]1CCN(C1)c1cc(OC(F)F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H23ClF3N5O3S2/c1-30(2)13-5-6-31(10-13)19-7-14(34-22(25)26)3-4-17(19)28-18-9-16(24)20(8-15(18)23)36(32,33)29-21-11-35-12-27-21/h3-4,7-9,11-13,22,28-29H,5-6,10H2,1-2H3/t13-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368300
PNG
(US10227338, Example 87)
Show SMILES COC1CCN(C1)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1/C21H19ClF4N4O3S2/c1-33-13-4-5-30(9-13)18-6-12(21(24,25)26)2-3-16(18)28-17-8-15(23)19(7-14(17)22)35(31,32)29-20-10-34-11-27-20/h2-3,6-8,10-11,13,28-29H,4-5,9H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368333
PNG
(US10227338, Example 120)
Show SMILES CNCCN(C)c1cc(OC)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C20H23ClFN5O3S2/c1-23-6-7-27(2)18-8-13(30-3)4-5-16(18)25-17-10-15(22)19(9-14(17)21)32(28,29)26-20-11-31-12-24-20/h4-5,8-12,23,25-26H,6-7H2,1-3H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368293
PNG
(US10227338, Example 76)
Show SMILES Fc1ccc(Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2cscn2)c(c1)N1CCCNCC1
Show InChI InChI=1S/C20H20ClF2N5O2S2/c21-14-9-19(32(29,30)27-20-11-31-12-25-20)15(23)10-17(14)26-16-3-2-13(22)8-18(16)28-6-1-4-24-5-7-28/h2-3,8-12,24,26-27H,1,4-7H2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368283
PNG
(US10227338, Example 66)
Show SMILES CN1CCN(CC1)c1cc(OC(F)F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H21ClF3N5O3S2/c1-29-4-6-30(7-5-29)18-8-13(33-21(24)25)2-3-16(18)27-17-10-15(23)19(9-14(17)22)35(31,32)28-20-11-34-12-26-20/h2-3,8-12,21,27-28H,4-7H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368225
PNG
(US10227338, Example 6)
Show SMILES CCN(CC)C1CCN(C1)c1cc(Cl)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C23H26Cl2FN5O2S2/c1-3-30(4-2)16-7-8-31(12-16)21-9-15(24)5-6-19(21)28-20-11-18(26)22(10-17(20)25)35(32,33)29-23-13-34-14-27-23/h5-6,9-11,13-14,16,28-29H,3-4,7-8,12H2,1-2H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368345
PNG
(US10227338, Example 132)
Show SMILES CNCCN(C)c1cc(OC)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)s1
Show InChI InChI=1S/C20H22ClF2N5O3S2/c1-24-6-7-28(2)17-8-12(31-3)4-5-15(17)26-16-10-14(22)18(9-13(16)21)33(29,30)27-20-25-11-19(23)32-20/h4-5,8-11,24,26H,6-7H2,1-3H3,(H,25,27)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368356
PNG
(US10227338, Example 143)
Show SMILES CNCCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cc(on1)C(C)(C)C
Show InChI InChI=1S/C23H28ClF2N5O3S/c1-23(2,3)21-13-22(29-34-21)30-35(32,33)20-11-15(24)18(12-16(20)26)28-17-7-6-14(25)10-19(17)31(5)9-8-27-4/h6-7,10-13,27-28H,8-9H2,1-5H3,(H,29,30)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368331
PNG
(US10227338, Example 118)
Show SMILES CNCCN(C)c1cc(OC)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C22H24ClF2N5O3S/c1-26-8-9-30(2)20-10-15(33-3)5-6-18(20)28-19-12-17(25)21(11-16(19)23)34(31,32)29-22-7-4-14(24)13-27-22/h4-7,10-13,26,28H,8-9H2,1-3H3,(H,27,29)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368253
PNG
(US10227338, Example 35)
Show SMILES NC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C19H18ClF2N5O2S2/c20-13-6-18(31(28,29)26-19-9-30-10-24-19)14(22)7-16(13)25-15-2-1-11(21)5-17(15)27-4-3-12(23)8-27/h1-2,5-7,9-10,12,25-26H,3-4,8,23H2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368295
PNG
(US10227338, Example 78)
Show SMILES CC(=O)N[C@@H]1CCN(C1)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1/C22H20ClF4N5O3S2/c1-12(33)29-14-4-5-32(9-14)19-6-13(22(25,26)27)2-3-17(19)30-18-8-16(24)20(7-15(18)23)37(34,35)31-21-10-36-11-28-21/h2-3,6-8,10-11,14,30-31H,4-5,9H2,1H3,(H,29,33)/t14-/s2
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368296
PNG
(US10227338, Example 79)
Show SMILES CC(=O)N[C@@H]1CCN(C1)c1cc(ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1/C22H21ClF3N5O3S2/c1-13(32)28-15-6-7-31(10-15)20-8-14(22(24,25)26)2-4-19(20)29-18-5-3-16(9-17(18)23)36(33,34)30-21-11-35-12-27-21/h2-5,8-9,11-12,15,29-30H,6-7,10H2,1H3,(H,28,32)/t15-/s2
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368325
PNG
(US10227338, Example 112 | US10227338, Example 115)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C21H22ClF2N5O2S/c1-25-9-10-29(2)19-6-4-3-5-17(19)27-18-12-16(24)20(11-15(18)22)32(30,31)28-21-8-7-14(23)13-26-21/h3-8,11-13,25,27H,9-10H2,1-2H3,(H,26,28)
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368319
PNG
(US10227338, Example 106)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccc(F)cn1)C#N
Show InChI InChI=1S/C22H21ClF2N6O2S/c1-27-7-8-31(2)20-9-14(12-26)3-5-18(20)29-19-11-17(25)21(10-16(19)23)34(32,33)30-22-6-4-15(24)13-28-22/h3-6,9-11,13,27,29H,7-8H2,1-2H3,(H,28,30)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368263
PNG
(US10227338, Example 45)
Show SMILES F[C@@H]1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C19H16ClF3N4O2S2/c20-13-6-18(31(28,29)26-19-9-30-10-24-19)14(23)7-16(13)25-15-2-1-11(21)5-17(15)27-4-3-12(22)8-27/h1-2,5-7,9-10,12,25-26H,3-4,8H2/t12-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368348
PNG
(US10227338, Example 135)
Show SMILES CNCCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cc(C)[nH]n1
Show InChI InChI=1S/C20H23ClF2N6O2S/c1-12-8-20(27-26-12)28-32(30,31)19-10-14(21)17(11-15(19)23)25-16-5-4-13(22)9-18(16)29(3)7-6-24-2/h4-5,8-11,24-25H,6-7H2,1-3H3,(H2,26,27,28)
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368351
PNG
(US10227338, Example 138)
Show SMILES CN(C)CCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H22ClF2N5O2S2/c1-27(2)7-8-28(3)18-10-13(22)4-5-16(18)25-17-12-15(23)19(11-14(17)21)32(29,30)26-20-24-6-9-31-20/h4-6,9-12,25H,7-8H2,1-3H3,(H,24,26)
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368286
PNG
(US10227338, Example 69)
Show SMILES CN[C@H]1CCN(C1)c1cc(F)ccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H21F2N5O2S2/c1-23-15-6-7-27(10-15)18-8-13(21)2-4-17(18)25-14-3-5-19(16(22)9-14)31(28,29)26-20-11-30-12-24-20/h2-5,8-9,11-12,15,23,25-26H,6-7,10H2,1H3/t15-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368252
PNG
(US10227338, Example 34)
Show SMILES NC1CCN(C1)c1cc(F)ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C19H19ClFN5O2S2/c20-15-8-14(30(27,28)25-19-10-29-11-23-19)2-4-16(15)24-17-3-1-12(21)7-18(17)26-6-5-13(22)9-26/h1-4,7-8,10-11,13,24-25H,5-6,9,22H2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368360
PNG
(US10227338, Example 147)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H21ClF2N6O2S/c1-25-14-5-7-30(11-14)19-8-13(23)2-3-17(19)28-18-10-16(24)20(9-15(18)22)33(31,32)29-21-4-6-26-12-27-21/h2-4,6,8-10,12,14,25,28H,5,7,11H2,1H3,(H,26,27,29)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368299
PNG
(US10227338, Example 86)
Show SMILES COC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H19ClF2N4O3S2/c1-30-13-4-5-27(9-13)18-6-12(22)2-3-16(18)25-17-8-15(23)19(7-14(17)21)32(28,29)26-20-10-31-11-24-20/h2-3,6-8,10-11,13,25-26H,4-5,9H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368291
PNG
(US10227338, Example 74)
Show SMILES CN(C)[C@@H]1CCN(C1)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1/C22H22ClF4N5O2S2/c1-31(2)14-5-6-32(10-14)19-7-13(22(25,26)27)3-4-17(19)29-18-9-16(24)20(8-15(18)23)36(33,34)30-21-11-35-12-28-21/h3-4,7-9,11-12,14,29-30H,5-6,10H2,1-2H3/t14-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368350
PNG
(US10227338, Example 137)
Show SMILES CN(C)CCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)N(C(=O)OC(C)(C)C)c1ncc(F)cn1
Show InChI InChI=1S/C26H30ClF3N6O4S/c1-26(2,3)40-25(37)36(24-31-14-17(29)15-32-24)41(38,39)23-12-18(27)21(13-19(23)30)33-20-8-7-16(28)11-22(20)35(6)10-9-34(4)5/h7-8,11-15,33H,9-10H2,1-6H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368362
PNG
(US10227338, Example 149)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cnccn1
Show InChI InChI=1/C21H21ClF2N6O2S/c1-25-14-4-7-30(12-14)19-8-13(23)2-3-17(19)28-18-10-16(24)20(9-15(18)22)33(31,32)29-21-11-26-5-6-27-21/h2-3,5-6,8-11,14,25,28H,4,7,12H2,1H3,(H,27,29)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368246
PNG
(US10227338, Example 28)
Show SMILES CN[C@@H]1CCN(C1)c1cc(F)ccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H21F2N5O2S2/c1-23-15-6-7-27(10-15)18-8-13(21)2-4-17(18)25-14-3-5-19(16(22)9-14)31(28,29)26-20-11-30-12-24-20/h2-5,8-9,11-12,15,23,25-26H,6-7,10H2,1H3/t15-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368258
PNG
(US10227338, Example 40 | US10227338, Example 50)
Show SMILES CNC1CCN(C1)c1ccccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H22ClN5O2S2/c1-22-14-8-9-26(11-14)19-5-3-2-4-18(19)24-17-7-6-15(10-16(17)21)30(27,28)25-20-12-29-13-23-20/h2-7,10,12-14,22,24-25H,8-9,11H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368306
PNG
(US10227338, Example 93)
Show SMILES CN(C)CCN(C)c1cc(F)ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C20H23ClFN5O2S2/c1-26(2)8-9-27(3)19-10-14(22)4-6-18(19)24-17-7-5-15(11-16(17)21)31(28,29)25-20-12-30-13-23-20/h4-7,10-13,24-25H,8-9H2,1-3H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368303
PNG
(US10227338, Example 90)
Show SMILES COC1CCN(C1)c1cc(ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1/C21H20ClF3N4O3S2/c1-32-14-6-7-29(10-14)19-8-13(21(23,24)25)2-4-18(19)27-17-5-3-15(9-16(17)22)34(30,31)28-20-11-33-12-26-20/h2-5,8-9,11-12,14,27-28H,6-7,10H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368242
PNG
(US10227338, Example 23)
Show SMILES CN[C@@H]1CCCN(C1)c1cc(F)ccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H23F2N5O2S2/c1-24-16-3-2-8-28(11-16)19-9-14(22)4-6-18(19)26-15-5-7-20(17(23)10-15)32(29,30)27-21-12-31-13-25-21/h4-7,9-10,12-13,16,24,26-27H,2-3,8,11H2,1H3/t16-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368355
PNG
(US10227338, Example 142)
Show SMILES CNCCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncco1
Show InChI InChI=1S/C19H20ClF2N5O3S/c1-23-5-7-27(2)17-9-12(21)3-4-15(17)25-16-11-14(22)18(10-13(16)20)31(28,29)26-19-24-6-8-30-19/h3-4,6,8-11,23,25H,5,7H2,1-2H3,(H,24,26)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368363
PNG
(US10227338, Example 150)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cc(C)on1
Show InChI InChI=1/C21H22ClF2N5O3S/c1-12-7-21(27-32-12)28-33(30,31)20-9-15(22)18(10-16(20)24)26-17-4-3-13(23)8-19(17)29-6-5-14(11-29)25-2/h3-4,7-10,14,25-26H,5-6,11H2,1-2H3,(H,27,28)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368247
PNG
(US10227338, Example 29)
Show SMILES CN[C@@H]1CCN(C1)c1cc(F)ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H21ClFN5O2S2/c1-23-14-6-7-27(10-14)19-8-13(22)2-4-18(19)25-17-5-3-15(9-16(17)21)31(28,29)26-20-11-30-12-24-20/h2-5,8-9,11-12,14,23,25-26H,6-7,10H2,1H3/t14-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368234
PNG
(US10227338, Example 15)
Show SMILES CNC1CCN(C1)c1cc(OC(F)(F)F)ccc1Nc1c(F)cc(cc1F)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H20F5N5O3S2/c1-27-12-4-5-31(9-12)18-6-13(34-21(24,25)26)2-3-17(18)29-20-15(22)7-14(8-16(20)23)36(32,33)30-19-10-35-11-28-19/h2-3,6-8,10-12,27,29-30H,4-5,9H2,1H3
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368232
PNG
(US10227338, Example 13)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H21F2N5O2S2/c1-23-15-6-7-27(10-15)18-8-13(21)2-4-17(18)25-14-3-5-19(16(22)9-14)31(28,29)26-20-11-30-12-24-20/h2-5,8-9,11-12,15,23,25-26H,6-7,10H2,1H3
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368265
PNG
(US10227338, Example 47)
Show SMILES CNC1CCN(C1)c1c(F)cccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H21ClFN5O2S2/c1-23-13-7-8-27(10-13)20-16(22)3-2-4-18(20)25-17-6-5-14(9-15(17)21)31(28,29)26-19-11-30-12-24-19/h2-6,9,11-13,23,25-26H,7-8,10H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368359
PNG
(US10227338, Example 146)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccn(C)n1
Show InChI InChI=1/C21H23ClF2N6O2S/c1-25-14-5-8-30(12-14)19-9-13(23)3-4-17(19)26-18-11-16(24)20(10-15(18)22)33(31,32)28-21-6-7-29(2)27-21/h3-4,6-7,9-11,14,25-26H,5,8,12H2,1-2H3,(H,27,28)
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368229
PNG
(US10227338, Example 10)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1ccc(cc1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H22FN5O2S2/c1-22-16-8-9-26(11-16)19-10-14(21)2-7-18(19)24-15-3-5-17(6-4-15)30(27,28)25-20-12-29-13-23-20/h2-7,10,12-13,16,22,24-25H,8-9,11H2,1H3
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368231
PNG
(US10227338, Example 12)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1c(F)cc(cc1F)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20F3N5O2S2/c1-24-13-4-5-28(9-13)18-6-12(21)2-3-17(18)26-20-15(22)7-14(8-16(20)23)32(29,30)27-19-10-31-11-25-19/h2-3,6-8,10-11,13,24,26-27H,4-5,9H2,1H3
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368288
PNG
(US10227338, Example 71)
Show SMILES COc1ccc(Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2cscn2)c(c1)N1CC[C@@H](C1)N(C)C
Show InChI InChI=1/C22H25ClFN5O3S2/c1-28(2)14-6-7-29(11-14)20-8-15(32-3)4-5-18(20)26-19-10-17(24)21(9-16(19)23)34(30,31)27-22-12-33-13-25-22/h4-5,8-10,12-14,26-27H,6-7,11H2,1-3H3/t14-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368233
PNG
(US10227338, Example 14)
Show SMILES CNC1CCN(C1)c1cc(OC(F)(F)F)ccc1Nc1ccc(cc1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H22F3N5O3S2/c1-25-15-8-9-29(11-15)19-10-16(32-21(22,23)24)4-7-18(19)27-14-2-5-17(6-3-14)34(30,31)28-20-12-33-13-26-20/h2-7,10,12-13,15,25,27-28H,8-9,11H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368320
PNG
(US10227338, Example 107)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccccn1)C#N
Show InChI InChI=1S/C22H22ClFN6O2S/c1-26-9-10-30(2)20-11-15(14-25)6-7-18(20)28-19-13-17(24)21(12-16(19)23)33(31,32)29-22-5-3-4-8-27-22/h3-8,11-13,26,28H,9-10H2,1-2H3,(H,27,29)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368335
PNG
(US10227338, Example 122)
Show SMILES CNCCN(C)c1cc(OC)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)cn1
Show InChI InChI=1S/C21H23ClF2N6O3S/c1-25-6-7-30(2)19-8-14(33-3)4-5-17(19)28-18-10-16(24)20(9-15(18)22)34(31,32)29-21-26-11-13(23)12-27-21/h4-5,8-12,25,28H,6-7H2,1-3H3,(H,26,27,29)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368227
PNG
(US10227338, Example 8)
Show SMILES CNC1CCN(C1)c1cc(C)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H23ClFN5O2S2/c1-13-3-4-17(19(7-13)28-6-5-14(10-28)24-2)26-18-9-16(23)20(8-15(18)22)32(29,30)27-21-11-31-12-25-21/h3-4,7-9,11-12,14,24,26-27H,5-6,10H2,1-2H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368282
PNG
(US10227338, Example 65)
Show SMILES CN1CCN(CC1)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1S/C21H20ClF4N5O2S2/c1-30-4-6-31(7-5-30)18-8-13(21(24,25)26)2-3-16(18)28-17-10-15(23)19(9-14(17)22)35(32,33)29-20-11-34-12-27-20/h2-3,8-12,28-29H,4-7H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368326
PNG
(US10227338, Example 113 | US10227338, Example 117)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccccn1
Show InChI InChI=1S/C21H23ClFN5O2S/c1-24-11-12-28(2)19-8-4-3-7-17(19)26-18-14-16(23)20(13-15(18)22)31(29,30)27-21-9-5-6-10-25-21/h3-10,13-14,24,26H,11-12H2,1-2H3,(H,25,27)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368257
PNG
(US10227338, Example 39 | US10227338, Example 49)
Show SMILES CNC1CCN(C1)c1ccccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H22FN5O2S2/c1-22-15-8-9-26(11-15)18-5-3-2-4-17(18)24-14-6-7-19(16(21)10-14)30(27,28)25-20-12-29-13-23-20/h2-7,10,12-13,15,22,24-25H,8-9,11H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368346
PNG
(US10227338, Example 133)
Show SMILES CN(CCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)N(C(=O)OC(C)(C)C)c1cc(C)on1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H38ClF2N5O7S/c1-18-14-26(35-45-18)38(28(40)44-30(5,6)7)46(41,42)25-16-20(31)23(17-21(25)33)34-22-11-10-19(32)15-24(22)36(8)12-13-37(9)27(39)43-29(2,3)4/h10-11,14-17,34H,12-13H2,1-9H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368264
PNG
(US10227338, Example 46)
Show SMILES CNC1CCN(C1)c1c(F)cccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H21F2N5O2S2/c1-23-14-7-8-27(10-14)20-15(21)3-2-4-17(20)25-13-5-6-18(16(22)9-13)31(28,29)26-19-11-30-12-24-19/h2-6,9,11-12,14,23,25-26H,7-8,10H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368279
PNG
(US10227338, Example 62)
Show SMILES CN1CCN(CC1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C20H20ClF2N5O2S2/c1-27-4-6-28(7-5-27)18-8-13(22)2-3-16(18)25-17-10-15(23)19(9-14(17)21)32(29,30)26-20-11-31-12-24-20/h2-3,8-12,25-26H,4-7H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368278
PNG
(US10227338, Example 61)
Show SMILES CN1CCN(CC1)c1cc(F)ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C20H21ClFN5O2S2/c1-26-6-8-27(9-7-26)19-10-14(22)2-4-18(19)24-17-5-3-15(11-16(17)21)31(28,29)25-20-12-30-13-23-20/h2-5,10-13,24-25H,6-9H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368273
PNG
(US10227338, Example 56)
Show SMILES CN[C@@H]1CCCN(C1)c1cc(OC)ccc1Nc1ccc(cc1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H27N5O3S2/c1-23-17-4-3-11-27(13-17)21-12-18(30-2)7-10-20(21)25-16-5-8-19(9-6-16)32(28,29)26-22-14-31-15-24-22/h5-10,12,14-15,17,23,25-26H,3-4,11,13H2,1-2H3/t17-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368259
PNG
(US10227338, Example 41)
Show SMILES F[C@@H]1CCN(C1)c1cc(F)ccc1Nc1ccc(cc1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C19H18F2N4O2S2/c20-13-1-6-17(18(9-13)25-8-7-14(21)10-25)23-15-2-4-16(5-3-15)29(26,27)24-19-11-28-12-22-19/h1-6,9,11-12,14,23-24H,7-8,10H2/t14-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368276
PNG
(US10227338, Example 59)
Show SMILES CN[C@@H]1CCCN(C1)c1cc(OC)ccc1Nc1c(F)cc(cc1F)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H25F2N5O3S2/c1-25-14-4-3-7-29(11-14)20-8-15(32-2)5-6-19(20)27-22-17(23)9-16(10-18(22)24)34(30,31)28-21-12-33-13-26-21/h5-6,8-10,12-14,25,27-28H,3-4,7,11H2,1-2H3/t14-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368274
PNG
(US10227338, Example 57)
Show SMILES CN[C@@H]1CCCN(C1)c1cc(OC)ccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H26FN5O3S2/c1-24-16-4-3-9-28(12-16)20-11-17(31-2)6-7-19(20)26-15-5-8-21(18(23)10-15)33(29,30)27-22-13-32-14-25-22/h5-8,10-11,13-14,16,24,26-27H,3-4,9,12H2,1-2H3/t16-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368251
PNG
(US10227338, Example 33)
Show SMILES NC1CCN(C1)c1cc(F)ccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C19H19F2N5O2S2/c20-12-1-3-16(17(7-12)26-6-5-13(22)9-26)24-14-2-4-18(15(21)8-14)30(27,28)25-19-10-29-11-23-19/h1-4,7-8,10-11,13,24-25H,5-6,9,22H2
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368248
PNG
(US10227338, Example 30)
Show SMILES CN[C@@H]1CCN(C1)c1cc(F)ccc1Nc1c(F)cc(cc1F)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20F3N5O2S2/c1-24-13-4-5-28(9-13)18-6-12(21)2-3-17(18)26-20-15(22)7-14(8-16(20)23)32(29,30)27-19-10-31-11-25-19/h2-3,6-8,10-11,13,24,26-27H,4-5,9H2,1H3/t13-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368245
PNG
(US10227338, Example 27)
Show SMILES CN[C@@H]1CCN(C1)c1cc(F)ccc1Nc1ccc(cc1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H22FN5O2S2/c1-22-16-8-9-26(11-16)19-10-14(21)2-7-18(19)24-15-3-5-17(6-4-15)30(27,28)25-20-12-29-13-23-20/h2-7,10,12-13,16,22,24-25H,8-9,11H2,1H3/t16-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368237
PNG
(US10227338, Example 18)
Show SMILES CNC1CCN(C1)c1cc(Cl)cnc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C19H19Cl2FN6O2S2/c1-23-12-2-3-28(8-12)16-4-11(20)7-24-19(16)26-15-6-14(22)17(5-13(15)21)32(29,30)27-18-9-31-10-25-18/h4-7,9-10,12,23,27H,2-3,8H2,1H3,(H,24,26)
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368262
PNG
(US10227338, Example 44)
Show SMILES F[C@@H]1CCN(C1)c1cc(F)ccc1Nc1c(F)cc(cc1F)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C19H16F4N4O2S2/c20-11-1-2-16(17(5-11)27-4-3-12(21)8-27)25-19-14(22)6-13(7-15(19)23)31(28,29)26-18-9-30-10-24-18/h1-2,5-7,9-10,12,25-26H,3-4,8H2/t12-/s2
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368260
PNG
(US10227338, Example 42)
Show SMILES F[C@@H]1CCN(C1)c1cc(F)ccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C19H17F3N4O2S2/c20-12-1-3-16(17(7-12)26-6-5-13(21)9-26)24-14-2-4-18(15(22)8-14)30(27,28)25-19-10-29-11-23-19/h1-4,7-8,10-11,13,24-25H,5-6,9H2/t13-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368271
PNG
(US10227338, Example 54)
Show SMILES CNC1CCN(C1)c1cc(OC)ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H24ClN5O3S2/c1-23-14-7-8-27(11-14)20-9-15(30-2)3-5-19(20)25-18-6-4-16(10-17(18)22)32(28,29)26-21-12-31-13-24-21/h3-6,9-10,12-14,23,25-26H,7-8,11H2,1-2H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368238
PNG
(US10227338, Example 19)
Show SMILES CNC1CCN(C1)c1nc(Cl)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C19H19Cl2FN6O2S2/c1-23-11-4-5-28(8-11)19-14(2-3-17(21)26-19)25-15-7-13(22)16(6-12(15)20)32(29,30)27-18-9-31-10-24-18/h2-3,6-7,9-11,23,25,27H,4-5,8H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368270
PNG
(US10227338, Example 53)
Show SMILES CNC1CCN(C1)c1cc(OC)ccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H24FN5O3S2/c1-23-15-7-8-27(11-15)19-10-16(30-2)4-5-18(19)25-14-3-6-20(17(22)9-14)32(28,29)26-21-12-31-13-24-21/h3-6,9-10,12-13,15,23,25-26H,7-8,11H2,1-2H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368261
PNG
(US10227338, Example 43)
Show SMILES F[C@@H]1CCN(C1)c1cc(F)ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C19H17ClF2N4O2S2/c20-15-8-14(30(27,28)25-19-10-29-11-23-19)2-4-16(15)24-17-3-1-12(21)7-18(17)26-6-5-13(22)9-26/h1-4,7-8,10-11,13,24-25H,5-6,9H2/t13-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368241
PNG
(US10227338, Example 22)
Show SMILES CN[C@@H]1CCCN(C1)c1cc(F)ccc1Nc1ccc(cc1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H24FN5O2S2/c1-23-17-3-2-10-27(12-17)20-11-15(22)4-9-19(20)25-16-5-7-18(8-6-16)31(28,29)26-21-13-30-14-24-21/h4-9,11,13-14,17,23,25-26H,2-3,10,12H2,1H3/t17-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368275
PNG
(US10227338, Example 58)
Show SMILES CN[C@@H]1CCCN(C1)c1cc(OC)ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H26ClN5O3S2/c1-24-15-4-3-9-28(12-15)21-10-16(31-2)5-7-20(21)26-19-8-6-17(11-18(19)23)33(29,30)27-22-13-32-14-25-22/h5-8,10-11,13-15,24,26-27H,3-4,9,12H2,1-2H3/t15-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368230
PNG
(US10227338, Example 11)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H21ClFN5O2S2/c1-23-14-6-7-27(10-14)19-8-13(22)2-4-18(19)25-17-5-3-15(9-16(17)21)31(28,29)26-20-11-30-12-24-20/h2-5,8-9,11-12,14,23,25-26H,6-7,10H2,1H3
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n/an/a 1.01E+3n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368313
PNG
(US10227338, Example 100)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)cn1)C#N
Show InChI InChI=1S/C21H20ClF2N7O2S/c1-26-5-6-31(2)19-7-13(10-25)3-4-17(19)29-18-9-16(24)20(8-15(18)22)34(32,33)30-21-27-11-14(23)12-28-21/h3-4,7-9,11-12,26,29H,5-6H2,1-2H3,(H,27,28,30)
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n/an/a 1.09E+3n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368281
PNG
(US10227338, Example 64)
Show SMILES CN(C)[C@H]1CCN(C1)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1/C22H22ClF4N5O2S2/c1-31(2)14-5-6-32(10-14)19-7-13(22(25,26)27)3-4-17(19)29-18-9-16(24)20(8-15(18)23)36(33,34)30-21-11-35-12-28-21/h3-4,7-9,11-12,14,29-30H,5-6,10H2,1-2H3/t14-/s2
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n/an/a 1.17E+3n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368302
PNG
(US10227338, Example 89)
Show SMILES COC1CCN(C1)c1cc(F)ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20ClFN4O3S2/c1-29-14-6-7-26(10-14)19-8-13(22)2-4-18(19)24-17-5-3-15(9-16(17)21)31(27,28)25-20-11-30-12-23-20/h2-5,8-9,11-12,14,24-25H,6-7,10H2,1H3
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n/an/a 1.22E+3n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368358
PNG
(US10227338, Example 145)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C19H19ClF2N6O2S2/c1-23-12-4-5-28(9-12)17-6-11(21)2-3-15(17)26-16-8-14(22)18(7-13(16)20)32(29,30)27-19-24-10-25-31-19/h2-3,6-8,10,12,23,26H,4-5,9H2,1H3,(H,24,25,27)
PDB

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n/an/a 1.40E+3n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368228
PNG
(US10227338, Example 9)
Show SMILES C[C@H]1CN(CCN1)c1cc(Cl)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20Cl2FN5O2S2/c1-12-9-28(5-4-24-12)18-6-13(21)2-3-16(18)26-17-8-15(23)19(7-14(17)22)32(29,30)27-20-10-31-11-25-20/h2-3,6-8,10-12,24,26-27H,4-5,9H2,1H3/t12-/s2
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n/an/a 1.51E+3n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368341
PNG
(US10227338, Example 128)
Show SMILES CNCCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)s1
Show InChI InChI=1S/C19H19ClF3N5O2S2/c1-24-5-6-28(2)16-7-11(21)3-4-14(16)26-15-9-13(22)17(8-12(15)20)32(29,30)27-19-25-10-18(23)31-19/h3-4,7-10,24,26H,5-6H2,1-2H3,(H,25,27)
PDB

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n/an/a 1.83E+3n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368301
PNG
(US10227338, Example 88)
Show SMILES CC(=O)N[C@@H]1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H20ClF2N5O3S2/c1-12(30)26-14-4-5-29(9-14)19-6-13(23)2-3-17(19)27-18-8-16(24)20(7-15(18)22)34(31,32)28-21-10-33-11-25-21/h2-3,6-8,10-11,14,27-28H,4-5,9H2,1H3,(H,26,30)/t14-/s2
PDB

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n/an/a 1.93E+3n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368240
PNG
(US10227338, Example 21 | US10227338, Example 52)
Show SMILES CNC1CCN(C1)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H21ClFN5O2S2/c1-23-13-6-7-27(10-13)18-5-3-2-4-16(18)25-17-9-15(22)19(8-14(17)21)31(28,29)26-20-11-30-12-24-20/h2-5,8-9,11-13,23,25-26H,6-7,10H2,1H3
PDB

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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368353
PNG
(US10227338, Example 140)
Show SMILES CN(C)CCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(Cl)s1
Show InChI InChI=1S/C20H22Cl2FN5O2S2/c1-27(2)8-9-28(3)17-7-5-4-6-15(17)25-16-11-14(23)18(10-13(16)21)32(29,30)26-20-24-12-19(22)31-20/h4-7,10-12,25H,8-9H2,1-3H3,(H,24,26)
PDB

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n/an/a 3.67E+3n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368340
PNG
(US10227338, Example 127)
Show SMILES CNCCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(Cl)s1
Show InChI InChI=1S/C19H19Cl2F2N5O2S2/c1-24-5-6-28(2)16-7-11(22)3-4-14(16)26-15-9-13(23)17(8-12(15)20)32(29,30)27-19-25-10-18(21)31-19/h3-4,7-10,24,26H,5-6H2,1-2H3,(H,25,27)
PDB

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n/an/a 5.54E+3n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368304
PNG
(US10227338, Example 91)
Show SMILES CC(=O)N[C@@H]1CCN(C1)c1cc(F)ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H21ClFN5O3S2/c1-13(29)25-15-6-7-28(10-15)20-8-14(23)2-4-19(20)26-18-5-3-16(9-17(18)22)33(30,31)27-21-11-32-12-24-21/h2-5,8-9,11-12,15,26-27H,6-7,10H2,1H3,(H,25,29)/t15-/s2
PDB

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n/an/a 6.58E+3n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368222
PNG
(US10227338, Example 3)
Show SMILES C[C@@H]1CNCCN1c1cc(Cl)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20Cl2FN5O2S2/c1-12-9-24-4-5-28(12)18-6-13(21)2-3-16(18)26-17-8-15(23)19(7-14(17)22)32(29,30)27-20-10-31-11-25-20/h2-3,6-8,10-12,24,26-27H,4-5,9H2,1H3/t12-/s2
PDB

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n/an/a 6.72E+3n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368308
PNG
(US10227338, Example 95)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1S/C20H20ClF4N5O2S2/c1-26-5-6-30(2)17-7-12(20(23,24)25)3-4-15(17)28-16-9-14(22)18(8-13(16)21)34(31,32)29-19-10-33-11-27-19/h3-4,7-11,26,28-29H,5-6H2,1-2H3
PDB

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n/an/a 8.20E+3n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368221
PNG
(US10227338, Example 2)
Show SMILES CNC1CCN(C1)c1cc(Cl)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20Cl2FN5O2S2/c1-24-13-4-5-28(9-13)18-6-12(21)2-3-16(18)26-17-8-15(23)19(7-14(17)22)32(29,30)27-20-10-31-11-25-20/h2-3,6-8,10-11,13,24,26-27H,4-5,9H2,1H3
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368266
PNG
(US10227338, Example 48)
Show SMILES CNC1CCN(C1)c1c(F)cccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20ClF2N5O2S2/c1-24-12-5-6-28(9-12)20-14(22)3-2-4-16(20)26-17-8-15(23)18(7-13(17)21)32(29,30)27-19-10-31-11-25-19/h2-4,7-8,10-12,24,26-27H,5-6,9H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368228
PNG
(US10227338, Example 9)
Show SMILES C[C@H]1CN(CCN1)c1cc(Cl)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20Cl2FN5O2S2/c1-12-9-28(5-4-24-12)18-6-13(21)2-3-16(18)26-17-8-15(23)19(7-14(17)22)32(29,30)27-20-10-31-11-25-20/h2-3,6-8,10-12,24,26-27H,4-5,9H2,1H3/t12-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368313
PNG
(US10227338, Example 100)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)cn1)C#N
Show InChI InChI=1S/C21H20ClF2N7O2S/c1-26-5-6-31(2)19-7-13(10-25)3-4-17(19)29-18-9-16(24)20(8-15(18)22)34(32,33)30-21-27-11-14(23)12-28-21/h3-4,7-9,11-12,26,29H,5-6H2,1-2H3,(H,27,28,30)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368229
PNG
(US10227338, Example 10)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1ccc(cc1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H22FN5O2S2/c1-22-16-8-9-26(11-16)19-10-14(21)2-7-18(19)24-15-3-5-17(6-4-15)30(27,28)25-20-12-29-13-23-20/h2-7,10,12-13,16,22,24-25H,8-9,11H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368254
PNG
(US10227338, Example 36)
Show SMILES CNC1CCN(C1)c1ccccc1Nc1ccc(cc1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H23N5O2S2/c1-21-16-10-11-25(12-16)19-5-3-2-4-18(19)23-15-6-8-17(9-7-15)29(26,27)24-20-13-28-14-22-20/h2-9,13-14,16,21,23-24H,10-12H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368272
PNG
(US10227338, Example 55)
Show SMILES CNC1CCN(C1)c1cc(OC)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H23ClFN5O3S2/c1-24-13-5-6-28(10-13)19-7-14(31-2)3-4-17(19)26-18-9-16(23)20(8-15(18)22)33(29,30)27-21-11-32-12-25-21/h3-4,7-9,11-13,24,26-27H,5-6,10H2,1-2H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368312
PNG
(US10227338, Example 99)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)C#N
Show InChI InChI=1S/C20H20ClFN6O2S2/c1-24-5-6-28(2)18-7-13(10-23)3-4-16(18)26-17-9-15(22)19(8-14(17)21)32(29,30)27-20-11-31-12-25-20/h3-4,7-9,11-12,24,26-27H,5-6H2,1-2H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368318
PNG
(US10227338, Example 105)
Show SMILES CNCCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H20ClF2N5O2S2/c1-23-5-7-27(2)17-9-12(21)3-4-15(17)25-16-11-14(22)18(10-13(16)20)31(28,29)26-19-24-6-8-30-19/h3-4,6,8-11,23,25H,5,7H2,1-2H3,(H,24,26)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368316
PNG
(US10227338, Example 103)
Show SMILES CN(CCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)N(C(=O)OC(C)(C)C)c1ccc(F)cn1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C31H37ClF3N5O6S/c1-30(2,3)45-28(41)39(8)14-13-38(7)25-15-19(33)9-11-23(25)37-24-17-22(35)26(16-21(24)32)47(43,44)40(29(42)46-31(4,5)6)27-12-10-20(34)18-36-27/h9-12,15-18,37H,13-14H2,1-8H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368280
PNG
(US10227338, Example 63)
Show SMILES CN(C)[C@H]1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H22ClF2N5O2S2/c1-28(2)14-5-6-29(10-14)19-7-13(23)3-4-17(19)26-18-9-16(24)20(8-15(18)22)33(30,31)27-21-11-32-12-25-21/h3-4,7-9,11-12,14,26-27H,5-6,10H2,1-2H3/t14-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368349
PNG
(US10227338, Example 136)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cc(C)[nH]n1
Show InChI InChI=1S/C20H24ClFN6O2S/c1-13-10-20(26-25-13)27-31(29,30)19-11-14(21)17(12-15(19)22)24-16-6-4-5-7-18(16)28(3)9-8-23-2/h4-7,10-12,23-24H,8-9H2,1-3H3,(H2,25,26,27)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368357
PNG
(US10227338, Example 144)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cc(on1)C(C)(C)C
Show InChI InChI=1S/C23H29ClFN5O3S/c1-23(2,3)21-14-22(28-33-21)29-34(31,32)20-12-15(24)18(13-16(20)25)27-17-8-6-7-9-19(17)30(5)11-10-26-4/h6-9,12-14,26-27H,10-11H2,1-5H3,(H,28,29)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368243
PNG
(US10227338, Example 24)
Show SMILES CN[C@@H]1CCCN(C1)c1cc(F)ccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H23ClFN5O2S2/c1-24-15-3-2-8-28(11-15)20-9-14(23)4-6-19(20)26-18-7-5-16(10-17(18)22)32(29,30)27-21-12-31-13-25-21/h4-7,9-10,12-13,15,24,26-27H,2-3,8,11H2,1H3/t15-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368257
PNG
(US10227338, Example 39 | US10227338, Example 49)
Show SMILES CNC1CCN(C1)c1ccccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H22FN5O2S2/c1-22-15-8-9-26(11-15)18-5-3-2-4-17(18)24-14-6-7-19(16(21)10-14)30(27,28)25-20-12-29-13-23-20/h2-7,10,12-13,15,22,24-25H,8-9,11H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368284
PNG
(US10227338, Example 67)
Show SMILES CN1CCN(CC1)c1cc(OC(F)(F)F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H20ClF4N5O3S2/c1-30-4-6-31(7-5-30)18-8-13(34-21(24,25)26)2-3-16(18)28-17-10-15(23)19(9-14(17)22)36(32,33)29-20-11-35-12-27-20/h2-3,8-12,28-29H,4-7H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368309
PNG
(US10227338, Example 96)
Show SMILES CN(CCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)N(C(=O)OC(C)(C)C)c1ncc(F)cn1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H36ClF3N6O6S/c1-29(2,3)45-27(41)39(8)12-11-38(7)24-13-18(32)9-10-22(24)37-23-15-21(34)25(14-20(23)31)47(43,44)40(28(42)46-30(4,5)6)26-35-16-19(33)17-36-26/h9-10,13-17,37H,11-12H2,1-8H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368319
PNG
(US10227338, Example 106)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccc(F)cn1)C#N
Show InChI InChI=1S/C22H21ClF2N6O2S/c1-27-7-8-31(2)20-9-14(12-26)3-5-18(20)29-19-11-17(25)21(10-16(19)23)34(32,33)30-22-6-4-15(24)13-28-22/h3-6,9-11,13,27,29H,7-8H2,1-2H3,(H,28,30)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368364
PNG
(US10227338, Example 151)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cncnc1
Show InChI InChI=1/C21H21ClF2N6O2S/c1-25-14-4-5-30(11-14)20-6-13(23)2-3-18(20)28-19-8-17(24)21(7-16(19)22)33(31,32)29-15-9-26-12-27-10-15/h2-3,6-10,12,14,25,28-29H,4-5,11H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368220
PNG
(US10227338, Example 1 | US10227338, Example 32)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20ClF2N5O2S2/c1-24-13-4-5-28(9-13)18-6-12(22)2-3-16(18)26-17-8-15(23)19(7-14(17)21)32(29,30)27-20-10-31-11-25-20/h2-3,6-8,10-11,13,24,26-27H,4-5,9H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368255
PNG
(US10227338, Example 37)
Show SMILES CNC1CCN(C1)c1cc(ccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1/C21H21F4N5O2S2/c1-26-15-6-7-30(10-15)18-8-13(21(23,24)25)2-4-17(18)28-14-3-5-19(16(22)9-14)34(31,32)29-20-11-33-12-27-20/h2-5,8-9,11-12,15,26,28-29H,6-7,10H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368240
PNG
(US10227338, Example 21 | US10227338, Example 52)
Show SMILES CNC1CCN(C1)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H21ClFN5O2S2/c1-23-13-6-7-27(10-13)18-5-3-2-4-16(18)25-17-9-15(22)19(8-14(17)21)31(28,29)26-20-11-30-12-24-20/h2-5,8-9,11-13,23,25-26H,6-7,10H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368310
PNG
(US10227338, Example 97)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)cn1)C(F)(F)F
Show InChI InChI=1S/C21H20ClF5N6O2S/c1-28-5-6-33(2)18-7-12(21(25,26)27)3-4-16(18)31-17-9-15(24)19(8-14(17)22)36(34,35)32-20-29-10-13(23)11-30-20/h3-4,7-11,28,31H,5-6H2,1-2H3,(H,29,30,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368363
PNG
(US10227338, Example 150)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cc(C)on1
Show InChI InChI=1/C21H22ClF2N5O3S/c1-12-7-21(27-32-12)28-33(30,31)20-9-15(22)18(10-16(20)24)26-17-4-3-13(23)8-19(17)29-6-5-14(11-29)25-2/h3-4,7-10,14,25-26H,5-6,11H2,1-2H3,(H,27,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM368364
PNG
(US10227338, Example 151)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cncnc1
Show InChI InChI=1/C21H21ClF2N6O2S/c1-25-14-4-5-30(11-14)20-6-13(23)2-3-18(20)28-19-8-17(24)21(7-16(19)22)33(31,32)29-15-9-26-12-27-10-15/h2-3,6-10,12,14,25,28-29H,4-5,11H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368314
PNG
(US10227338, Example 101 | US10227338, Example 102)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)cn1
Show InChI InChI=1S/C20H21ClF2N6O2S/c1-24-7-8-29(2)18-6-4-3-5-16(18)27-17-10-15(23)19(9-14(17)21)32(30,31)28-20-25-11-13(22)12-26-20/h3-6,9-12,24,27H,7-8H2,1-2H3,(H,25,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368314
PNG
(US10227338, Example 101 | US10227338, Example 102)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)cn1
Show InChI InChI=1S/C20H21ClF2N6O2S/c1-24-7-8-29(2)18-6-4-3-5-16(18)27-17-10-15(23)19(9-14(17)21)32(30,31)28-20-25-11-13(22)12-26-20/h3-6,9-12,24,27H,7-8H2,1-2H3,(H,25,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368317
PNG
(US10227338, Example 104)
Show SMILES CNCCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccccn1
Show InChI InChI=1S/C21H22ClF2N5O2S/c1-25-9-10-29(2)19-11-14(23)6-7-17(19)27-18-13-16(24)20(12-15(18)22)32(30,31)28-21-5-3-4-8-26-21/h3-8,11-13,25,27H,9-10H2,1-2H3,(H,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368244
PNG
(US10227338, Example 26)
Show SMILES CN[C@@H]1CCCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H22ClF2N5O2S2/c1-25-14-3-2-6-29(10-14)19-7-13(23)4-5-17(19)27-18-9-16(24)20(8-15(18)22)33(30,31)28-21-11-32-12-26-21/h4-5,7-9,11-12,14,25,27-28H,2-3,6,10H2,1H3/t14-/s2
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368220
PNG
(US10227338, Example 1 | US10227338, Example 32)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H20ClF2N5O2S2/c1-24-13-4-5-28(9-13)18-6-12(22)2-3-16(18)26-17-8-15(23)19(7-14(17)21)32(29,30)27-20-10-31-11-25-20/h2-3,6-8,10-11,13,24,26-27H,4-5,9H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368258
PNG
(US10227338, Example 40 | US10227338, Example 50)
Show SMILES CNC1CCN(C1)c1ccccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H22ClN5O2S2/c1-22-14-8-9-26(11-14)19-5-3-2-4-18(19)24-17-7-6-15(10-16(17)21)30(27,28)25-20-12-29-13-23-20/h2-7,10,12-14,22,24-25H,8-9,11H2,1H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368311
PNG
(US10227338, Example 121 | US10227338, Example 98)
Show SMILES CNCCN(C)c1ccccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C19H21ClFN5O2S2/c1-22-7-8-26(2)17-6-4-3-5-15(17)24-16-10-14(21)18(9-13(16)20)30(27,28)25-19-11-29-12-23-19/h3-6,9-12,22,24-25H,7-8H2,1-2H3
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368361
PNG
(US10227338, Example 148)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)cn1
Show InChI InChI=1/C21H20ClF3N6O2S/c1-26-14-4-5-31(11-14)19-6-12(23)2-3-17(19)29-18-8-16(25)20(7-15(18)22)34(32,33)30-21-27-9-13(24)10-28-21/h2-3,6-10,14,26,29H,4-5,11H2,1H3,(H,27,28,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368362
PNG
(US10227338, Example 149)
Show SMILES CNC1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cnccn1
Show InChI InChI=1/C21H21ClF2N6O2S/c1-25-14-4-7-30(12-14)19-8-13(23)2-3-17(19)28-18-10-16(24)20(9-15(18)22)33(31,32)29-21-11-26-5-6-27-21/h2-3,5-6,8-11,14,25,28H,4,7,12H2,1H3,(H,27,29)
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Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM368305
PNG
(US10227338, Example 92)
Show SMILES CN(CCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)N(C(=O)OC(C)(C)C)c1cscn1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H36ClF2N5O6S2/c1-28(2,3)42-26(38)36(8)12-11-35(7)23-13-18(31)9-10-21(23)34-22-15-20(32)24(14-19(22)30)45(40,41)37(25-16-44-17-33-25)27(39)43-29(4,5)6/h9-10,13-17,34H,11-12H2,1-8H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%