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Patent code US10227342

Compile Data Set for Download or QSAR

Found 400 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368372
PNG
(US10227342, Example 8)
Show SMILES COC(=O)c1cnc(Nc2cc(NC(=O)C=C)c(cc2OC)N(C)CCN(C)C)nc1-c1cn(C)c2ccccc12
Show InChI InChI=1S/C30H35N7O4/c1-8-27(38)32-22-15-23(26(40-6)16-25(22)36(4)14-13-35(2)3)33-30-31-17-20(29(39)41-7)28(34-30)21-18-37(5)24-12-10-9-11-19(21)24/h8-12,15-18H,1,13-14H2,2-7H3,(H,32,38)(H,31,33,34)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368375
PNG
(US10227342, Example 11)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC2COC2)c(n1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C32H37N7O5/c1-7-29(40)34-24-14-25(28(42-6)15-27(24)38(4)13-12-37(2)3)35-32-33-16-22(31(41)44-20-18-43-19-20)30(36-32)23-17-39(5)26-11-9-8-10-21(23)26/h7-11,14-17,20H,1,12-13,18-19H2,2-6H3,(H,34,40)(H,33,35,36)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368375
PNG
(US10227342, Example 11)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC2COC2)c(n1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C32H37N7O5/c1-7-29(40)34-24-14-25(28(42-6)15-27(24)38(4)13-12-37(2)3)35-32-33-16-22(31(41)44-20-18-43-19-20)30(36-32)23-17-39(5)26-11-9-8-10-21(23)26/h7-11,14-17,20H,1,12-13,18-19H2,2-6H3,(H,34,40)(H,33,35,36)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368379
PNG
(US10227342, Example 14)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC2CCC2)c(n1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C33H39N7O4/c1-7-30(41)35-25-17-26(29(43-6)18-28(25)39(4)16-15-38(2)3)36-33-34-19-23(32(42)44-21-11-10-12-21)31(37-33)24-20-40(5)27-14-9-8-13-22(24)27/h7-9,13-14,17-21H,1,10-12,15-16H2,2-6H3,(H,35,41)(H,34,36,37)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368379
PNG
(US10227342, Example 14)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC2CCC2)c(n1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C33H39N7O4/c1-7-30(41)35-25-17-26(29(43-6)18-28(25)39(4)16-15-38(2)3)36-33-34-19-23(32(42)44-21-11-10-12-21)31(37-33)24-20-40(5)27-14-9-8-13-22(24)27/h7-9,13-14,17-21H,1,10-12,15-16H2,2-6H3,(H,35,41)(H,34,36,37)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368380
PNG
(US10227342, Example 15)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-n1ccc2ccccc12
Show InChI InChI=1S/C31H37N7O4/c1-8-28(39)33-23-17-24(27(41-7)18-26(23)37(6)16-15-36(4)5)34-31-32-19-22(30(40)42-20(2)3)29(35-31)38-14-13-21-11-9-10-12-25(21)38/h8-14,17-20H,1,15-16H2,2-7H3,(H,33,39)(H,32,34,35)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368382
PNG
(US10227342, Example 17)
Show SMILES COc1cc(N(C)CC2CCCN2C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-c1cn(C)c2ccccc12
Show InChI InChI=1/C34H41N7O4/c1-8-31(42)36-26-16-27(30(44-7)17-29(26)40(5)19-22-12-11-15-39(22)4)37-34-35-18-24(33(43)45-21(2)3)32(38-34)25-20-41(6)28-14-10-9-13-23(25)28/h8-10,13-14,16-18,20-22H,1,11-12,15,19H2,2-7H3,(H,36,42)(H,35,37,38)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368385
PNG
(US10227342, Example 20)
Show SMILES COc1ccc(NC(=O)C=C)cc1Nc1ncc(C#N)c(n1)-c1cn(C)c2cc(OCCN3CCCC3)ccc12
Show InChI InChI=1S/C30H31N7O3/c1-4-28(38)33-21-7-10-27(39-3)25(15-21)34-30-32-18-20(17-31)29(35-30)24-19-36(2)26-16-22(8-9-23(24)26)40-14-13-37-11-5-6-12-37/h4,7-10,15-16,18-19H,1,5-6,11-14H2,2-3H3,(H,33,38)(H,32,34,35)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368389
PNG
(US10227342, Example 23)
Show SMILES COc1ccc(NC(=O)C=C)cc1Nc1ncc(C#N)c(n1)-c1cn(C)c2cc(OCCC3CCCN3C)ccc12
Show InChI InChI=1/C31H33N7O3/c1-5-29(39)34-21-8-11-28(40-4)26(15-21)35-31-33-18-20(17-32)30(36-31)25-19-38(3)27-16-23(9-10-24(25)27)41-14-12-22-7-6-13-37(22)2/h5,8-11,15-16,18-19,22H,1,6-7,12-14H2,2-4H3,(H,34,39)(H,33,35,36)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50029668
PNG
(AZD-9291 | OSIMERTINIB | Osimertinib | US10085983,...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50029686
PNG
(CHEMBL3353405 | US10227342, Example 25)
Show SMILES COc1cc(N2CC(C2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn2ccccc12
Show InChI InChI=1S/C26H27ClN8O2/c1-5-24(36)30-19-10-20(23(37-4)11-22(19)34-14-16(15-34)33(2)3)31-26-28-13-18(27)25(32-26)17-12-29-35-9-7-6-8-21(17)35/h5-13,16H,1,14-15H2,2-4H3,(H,30,36)(H,28,31,32)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368396
PNG
(US10227342, Example 30)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C31H37N7O4/c1-8-28(39)34-24-15-25(27(41-7)16-26(24)38(6)14-13-37(4)5)35-31-33-18-22(30(40)42-19(2)3)29(36-31)21-17-32-23-12-10-9-11-20(21)23/h8-12,15-19,32H,1,13-14H2,2-7H3,(H,34,39)(H,33,35,36)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368396
PNG
(US10227342, Example 30)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C31H37N7O4/c1-8-28(39)34-24-15-25(27(41-7)16-26(24)38(6)14-13-37(4)5)35-31-33-18-22(30(40)42-19(2)3)29(36-31)21-17-32-23-12-10-9-11-20(21)23/h8-12,15-19,32H,1,13-14H2,2-7H3,(H,34,39)(H,33,35,36)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368397
PNG
(US10227342, Example 31)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-c1cn(C)c2c(OC)cccc12
Show InChI InChI=1S/C33H41N7O5/c1-10-29(41)35-24-16-25(28(44-9)17-26(24)39(6)15-14-38(4)5)36-33-34-18-22(32(42)45-20(2)3)30(37-33)23-19-40(7)31-21(23)12-11-13-27(31)43-8/h10-13,16-20H,1,14-15H2,2-9H3,(H,35,41)(H,34,36,37)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368402
PNG
(US10227342, Example 36)
Show SMILES COc1cc(N(C)C[C@H]2CCCN2C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-c1cn(C)c2ccccc12
Show InChI InChI=1/C34H41N7O4/c1-8-31(42)36-26-16-27(30(44-7)17-29(26)40(5)19-22-12-11-15-39(22)4)37-34-35-18-24(33(43)45-21(2)3)32(38-34)25-20-41(6)28-14-10-9-13-23(25)28/h8-10,13-14,16-18,20-22H,1,11-12,15,19H2,2-7H3,(H,36,42)(H,35,37,38)/t22-/s2
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368410
PNG
(N-(5-((5-chloro-4-(1-methyl-1,6,7,8-tetrahydrocycl...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cn(C)c2c3CCCc3ccc12
Show InChI InChI=1S/C31H36ClN7O2/c1-7-28(40)34-24-15-25(27(41-6)16-26(24)38(4)14-13-37(2)3)35-31-33-17-23(32)29(36-31)22-18-39(5)30-20-10-8-9-19(20)11-12-21(22)30/h7,11-12,15-18H,1,8-10,13-14H2,2-6H3,(H,34,40)(H,33,35,36)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368415
PNG
(US10227342, Example 47)
Show SMILES CCN(CC)CC(COC)Oc1cc(OC)c(Nc2ncc(Cl)c(n2)-c2cnn3ccccc23)cc1NC(=O)C=C
Show InChI InChI=1/C29H34ClN7O4/c1-6-27(38)33-23-13-22(25(40-5)14-26(23)41-19(18-39-4)17-36(7-2)8-3)34-29-31-16-21(30)28(35-29)20-15-32-37-12-10-9-11-24(20)37/h6,9-16,19H,1,7-8,17-18H2,2-5H3,(H,33,38)(H,31,34,35)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50029685
PNG
(CHEMBL3353404 | US10227342, Example 52)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn2ccccc12
Show InChI InChI=1S/C26H29ClN8O2/c1-6-24(36)30-19-13-20(23(37-5)14-22(19)34(4)12-11-33(2)3)31-26-28-16-18(27)25(32-26)17-15-29-35-10-8-7-9-21(17)35/h6-10,13-16H,1,11-12H2,2-5H3,(H,30,36)(H,28,31,32)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
egfr exon 21 l858r and t790m mutation


(Homo sapiens (Human))
BDBM50029685
PNG
(CHEMBL3353404 | US10227342, Example 52)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn2ccccc12
Show InChI InChI=1S/C26H29ClN8O2/c1-6-24(36)30-19-13-20(23(37-5)14-22(19)34(4)12-11-33(2)3)31-26-28-16-18(27)25(32-26)17-15-29-35-10-8-7-9-21(17)35/h6-10,13-16H,1,11-12H2,2-5H3,(H,30,36)(H,28,31,32)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR L858R and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine pro-B cell l...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50029664
PNG
(CHEMBL3353408 | US10227342, Example 56)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C27H30ClN7O2/c1-6-25(36)31-21-13-22(24(37-5)14-23(21)35(4)12-11-34(2)3)32-27-30-16-19(28)26(33-27)18-15-29-20-10-8-7-9-17(18)20/h6-10,13-16,29H,1,11-12H2,2-5H3,(H,31,36)(H,30,32,33)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
egfr exon 21 l858r and t790m mutation


(Homo sapiens (Human))
BDBM50029664
PNG
(CHEMBL3353408 | US10227342, Example 56)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C27H30ClN7O2/c1-6-25(36)31-21-13-22(24(37-5)14-23(21)35(4)12-11-34(2)3)32-27-30-16-19(28)26(33-27)18-15-29-20-10-8-7-9-17(18)20/h6-10,13-16,29H,1,11-12H2,2-5H3,(H,31,36)(H,30,32,33)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR L858R and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine pro-B cell l...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368426
PNG
(US10227342, Example 58)
Show SMILES CNCCN(C)c1cc(OC)c(Nc2ncc(C(=O)OC(C)C)c(n2)-c2cn(C)c3ccccc23)cc1NC(=O)C=C
Show InChI InChI=1S/C31H37N7O4/c1-8-28(39)34-23-15-24(27(41-7)16-26(23)37(5)14-13-32-4)35-31-33-17-21(30(40)42-19(2)3)29(36-31)22-18-38(6)25-12-10-9-11-20(22)25/h8-12,15-19,32H,1,13-14H2,2-7H3,(H,34,39)(H,33,35,36)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368426
PNG
(US10227342, Example 58)
Show SMILES CNCCN(C)c1cc(OC)c(Nc2ncc(C(=O)OC(C)C)c(n2)-c2cn(C)c3ccccc23)cc1NC(=O)C=C
Show InChI InChI=1S/C31H37N7O4/c1-8-28(39)34-23-15-24(27(41-7)16-26(23)37(5)14-13-32-4)35-31-33-17-21(30(40)42-19(2)3)29(36-31)22-18-38(6)25-12-10-9-11-20(22)25/h8-12,15-19,32H,1,13-14H2,2-7H3,(H,34,39)(H,33,35,36)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368428
PNG
(US10227342, Example 60)
Show SMILES CCC(=O)Nc1cnc(Nc2cc(NC(=O)C=C)c(cc2OC)N(C)CCN(C)C)nc1-c1nn(C)c2ccccc12
Show InChI InChI=1S/C30H37N9O3/c1-8-26(40)32-20-16-21(25(42-7)17-24(20)38(5)15-14-37(3)4)34-30-31-18-22(33-27(41)9-2)29(35-30)28-19-12-10-11-13-23(19)39(6)36-28/h8,10-13,16-18H,1,9,14-15H2,2-7H3,(H,32,40)(H,33,41)(H,31,34,35)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368431
PNG
(US10227342, Example 63)
Show SMILES COC(=O)c1cnc(Nc2cc(NC(=O)C=C)c(cc2OC)N(C)C[C@H]2CCCN2C)nc1-n1ccc2ccccc12
Show InChI InChI=1/C31H35N7O4/c1-6-28(39)33-23-16-24(27(41-4)17-26(23)37(3)19-21-11-9-14-36(21)2)34-31-32-18-22(30(40)42-5)29(35-31)38-15-13-20-10-7-8-12-25(20)38/h6-8,10,12-13,15-18,21H,1,9,11,14,19H2,2-5H3,(H,33,39)(H,32,34,35)/t21-/s2
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368432
PNG
(US10227342, Example 64)
Show SMILES COc1cc(N(C)C[C@H]2CCCN2C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-c1c[nH]c2ccccc12
Show InChI InChI=1/C33H39N7O4/c1-7-30(41)36-26-15-27(29(43-6)16-28(26)40(5)19-21-11-10-14-39(21)4)37-33-35-18-24(32(42)44-20(2)3)31(38-33)23-17-34-25-13-9-8-12-22(23)25/h7-9,12-13,15-18,20-21,34H,1,10-11,14,19H2,2-6H3,(H,36,41)(H,35,37,38)/t21-/s2
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
egfr exon 21 l858r and t790m mutation


(Homo sapiens (Human))
BDBM368435
PNG
(US10227342, Example 67)
Show SMILES COc1cc(OCCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C31H36N6O5/c1-8-28(38)33-24-15-23(26(40-7)16-27(24)41-14-13-36(4)5)34-31-32-17-21(30(39)42-19(2)3)29(35-31)22-18-37(6)25-12-10-9-11-20(22)25/h8-12,15-19H,1,13-14H2,2-7H3,(H,33,38)(H,32,34,35)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR L858R and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine pro-B cell l...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368438
PNG
(US10227342, Example 70)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(CC(N)=O)c2ccccc12
Show InChI InChI=1S/C29H34N8O3/c1-6-28(39)32-22-15-23(26(40-5)16-25(22)36(4)14-13-35(2)3)34-29-31-12-11-21(33-29)20-17-37(18-27(30)38)24-10-8-7-9-19(20)24/h6-12,15-17H,1,13-14,18H2,2-5H3,(H2,30,38)(H,32,39)(H,31,33,34)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368445
PNG
(US10227342, Example 76)
Show SMILES COC(=O)c1cnc(Nc2cc(NC(=O)C=C)c(cc2OC)N(C)CCN(C)C)nc1-c1cn(N(C)C)c2ccccc12
Show InChI InChI=1S/C31H38N8O4/c1-9-28(40)33-23-16-24(27(42-7)17-26(23)38(6)15-14-36(2)3)34-31-32-18-21(30(41)43-8)29(35-31)22-19-39(37(4)5)25-13-11-10-12-20(22)25/h9-13,16-19H,1,14-15H2,2-8H3,(H,33,40)(H,32,34,35)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368448
PNG
(US10227342, Example 79)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-c1cn(C2CC2)c2ccccc12
Show InChI InChI=1S/C34H41N7O4/c1-8-31(42)36-26-17-27(30(44-7)18-29(26)40(6)16-15-39(4)5)37-34-35-19-24(33(43)45-21(2)3)32(38-34)25-20-41(22-13-14-22)28-12-10-9-11-23(25)28/h8-12,17-22H,1,13-16H2,2-7H3,(H,36,42)(H,35,37,38)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368455
PNG
(US10227342, Example 85)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C)c2c(cccc12)C(=O)OC(C)C
Show InChI InChI=1S/C32H39N7O4/c1-9-29(40)34-25-17-26(28(42-8)18-27(25)38(6)16-15-37(4)5)36-32-33-14-13-24(35-32)23-19-39(7)30-21(23)11-10-12-22(30)31(41)43-20(2)3/h9-14,17-20H,1,15-16H2,2-8H3,(H,34,40)(H,33,35,36)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368460
PNG
(US10227342, Example 89)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C)c2cc(ccc12)C#N
Show InChI InChI=1S/C29H32N8O2/c1-7-28(38)32-23-15-24(27(39-6)16-26(23)36(4)13-12-35(2)3)34-29-31-11-10-22(33-29)21-18-37(5)25-14-19(17-30)8-9-20(21)25/h7-11,14-16,18H,1,12-13H2,2-6H3,(H,32,38)(H,31,33,34)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368462
PNG
(US10227342, Example 90)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1c(C(N)=O)n(C)c2ccccc12
Show InChI InChI=1S/C29H34N8O3/c1-7-25(38)32-20-16-21(24(40-6)17-23(20)36(4)15-14-35(2)3)34-29-31-13-12-19(33-29)26-18-10-8-9-11-22(18)37(5)27(26)28(30)39/h7-13,16-17H,1,14-15H2,2-6H3,(H2,30,39)(H,32,38)(H,31,33,34)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368464
PNG
(US10227342, Example 92)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1c(C(=O)N(C)C)n(C)c2ccccc12
Show InChI InChI=1S/C31H38N8O3/c1-9-27(40)33-22-18-23(26(42-8)19-25(22)38(6)17-16-36(2)3)35-31-32-15-14-21(34-31)28-20-12-10-11-13-24(20)39(7)29(28)30(41)37(4)5/h9-15,18-19H,1,16-17H2,2-8H3,(H,33,40)(H,32,34,35)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368469
PNG
(US10227342, Example 97)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-n1cc(C)c2ccccc12
Show InChI InChI=1S/C32H39N7O4/c1-9-29(40)34-24-16-25(28(42-8)17-27(24)38(7)15-14-37(5)6)35-32-33-18-23(31(41)43-20(2)3)30(36-32)39-19-21(4)22-12-10-11-13-26(22)39/h9-13,16-20H,1,14-15H2,2-8H3,(H,34,40)(H,33,35,36)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368367
PNG
(US10227342, Example 3)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncnc(n1)-c1c(-c2ccccc2)n(C)c2ccccc12
Show InChI InChI=1S/C33H36N8O2/c1-7-29(42)36-24-19-25(28(43-6)20-27(24)40(4)18-17-39(2)3)37-33-35-21-34-32(38-33)30-23-15-11-12-16-26(23)41(5)31(30)22-13-9-8-10-14-22/h7-16,19-21H,1,17-18H2,2-6H3,(H,36,42)(H,34,35,37,38)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368371
PNG
(US10227342, Example 7)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1c(-c2ccccc2)n(C)c2ccccc12
Show InChI InChI=1S/C34H37N7O2/c1-7-31(42)36-26-21-27(30(43-6)22-29(26)40(4)20-19-39(2)3)38-34-35-18-17-25(37-34)32-24-15-11-12-16-28(24)41(5)33(32)23-13-9-8-10-14-23/h7-18,21-22H,1,19-20H2,2-6H3,(H,36,42)(H,35,37,38)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368372
PNG
(US10227342, Example 8)
Show SMILES COC(=O)c1cnc(Nc2cc(NC(=O)C=C)c(cc2OC)N(C)CCN(C)C)nc1-c1cn(C)c2ccccc12
Show InChI InChI=1S/C30H35N7O4/c1-8-27(38)32-22-15-23(26(40-6)16-25(22)36(4)14-13-35(2)3)33-30-31-17-20(29(39)41-7)28(34-30)21-18-37(5)24-12-10-9-11-19(21)24/h8-12,15-18H,1,13-14H2,2-7H3,(H,32,38)(H,31,33,34)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368380
PNG
(US10227342, Example 15)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-n1ccc2ccccc12
Show InChI InChI=1S/C31H37N7O4/c1-8-28(39)33-23-17-24(27(41-7)18-26(23)37(6)16-15-36(4)5)34-31-32-19-22(30(40)42-20(2)3)29(35-31)38-14-13-21-11-9-10-12-25(21)38/h8-14,17-20H,1,15-16H2,2-7H3,(H,33,39)(H,32,34,35)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368380
PNG
(US10227342, Example 15)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-n1ccc2ccccc12
Show InChI InChI=1S/C31H37N7O4/c1-8-28(39)33-23-17-24(27(41-7)18-26(23)37(6)16-15-36(4)5)34-31-32-19-22(30(40)42-20(2)3)29(35-31)38-14-13-21-11-9-10-12-25(21)38/h8-14,17-20H,1,15-16H2,2-7H3,(H,33,39)(H,32,34,35)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368381
PNG
(US10227342, Example 16)
Show SMILES COC(=O)c1cnc(Nc2cc(NC(=O)C=C)c(cc2OC)N(C)CC2CCCN2C)nc1-c1cn(C)c2ccccc12
Show InChI InChI=1/C32H37N7O4/c1-7-29(40)34-24-15-25(28(42-5)16-27(24)38(3)18-20-11-10-14-37(20)2)35-32-33-17-22(31(41)43-6)30(36-32)23-19-39(4)26-13-9-8-12-21(23)26/h7-9,12-13,15-17,19-20H,1,10-11,14,18H2,2-6H3,(H,34,40)(H,33,35,36)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368386
PNG
(US10227342, Example 21)
Show SMILES COc1ccc(NC(=O)C=C)cc1Nc1ncc(C#N)c(n1)-c1cn(C)c2cc(OCC3CCCN3C)ccc12
Show InChI InChI=1/C30H31N7O3/c1-5-28(38)33-20-8-11-27(39-4)25(13-20)34-30-32-16-19(15-31)29(35-30)24-17-37(3)26-14-22(9-10-23(24)26)40-18-21-7-6-12-36(21)2/h5,8-11,13-14,16-17,21H,1,6-7,12,18H2,2-4H3,(H,33,38)(H,32,34,35)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM368395
PNG
(US10227342, Example 29)
Show SMILES CCC(C)OC(=O)c1cnc(Nc2cc(NC(=O)C=C)c(cc2OC)N(C)CCN(C)C)nc1-c1cn(C)c2ccccc12
Show InChI InChI=1/C33H41N7O4/c1-9-21(3)44-32(42)23-19-34-33(37-31(23)24-20-40(7)27-14-12-11-13-22(24)27)36-26-17-25(35-30(41)10-2)28(18-29(26)43-8)39(6)16-15-38(4)5/h10-14,17-21H,2,9,15-16H2,1,3-8H3,(H,35,41)(H,34,36,37)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368395
PNG
(US10227342, Example 29)
Show SMILES CCC(C)OC(=O)c1cnc(Nc2cc(NC(=O)C=C)c(cc2OC)N(C)CCN(C)C)nc1-c1cn(C)c2ccccc12
Show InChI InChI=1/C33H41N7O4/c1-9-21(3)44-32(42)23-19-34-33(37-31(23)24-20-40(7)27-14-12-11-13-22(24)27)36-26-17-25(35-30(41)10-2)28(18-29(26)43-8)39(6)16-15-38(4)5/h10-14,17-21H,2,9,15-16H2,1,3-8H3,(H,35,41)(H,34,36,37)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368397
PNG
(US10227342, Example 31)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-c1cn(C)c2c(OC)cccc12
Show InChI InChI=1S/C33H41N7O5/c1-10-29(41)35-24-16-25(28(44-9)17-26(24)39(6)15-14-38(4)5)36-33-34-18-22(32(42)45-20(2)3)30(37-33)23-19-40(7)31-21(23)12-11-13-27(31)43-8/h10-13,16-20H,1,14-15H2,2-9H3,(H,35,41)(H,34,36,37)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368401
PNG
(US10227342, Example 35)
Show SMILES COc1cc(N(C)C[C@@H]2CCCN2C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-c1cn(C)c2ccccc12
Show InChI InChI=1/C34H41N7O4/c1-8-31(42)36-26-16-27(30(44-7)17-29(26)40(5)19-22-12-11-15-39(22)4)37-34-35-18-24(33(43)45-21(2)3)32(38-34)25-20-41(6)28-14-10-9-13-23(25)28/h8-10,13-14,16-18,20-22H,1,11-12,15,19H2,2-7H3,(H,36,42)(H,35,37,38)/t22-/s2
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
egfr exon 21 l858r and t790m mutation


(Homo sapiens (Human))
BDBM368401
PNG
(US10227342, Example 35)
Show SMILES COc1cc(N(C)C[C@@H]2CCCN2C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-c1cn(C)c2ccccc12
Show InChI InChI=1/C34H41N7O4/c1-8-31(42)36-26-16-27(30(44-7)17-29(26)40(5)19-22-12-11-15-39(22)4)37-34-35-18-24(33(43)45-21(2)3)32(38-34)25-20-41(6)28-14-10-9-13-23(25)28/h8-10,13-14,16-18,20-22H,1,11-12,15,19H2,2-7H3,(H,36,42)(H,35,37,38)/t22-/s2
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR L858R and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine pro-B cell l...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368404
PNG
(US10227342, Example 38)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OCC#N)c(n1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C31H34N8O4/c1-7-28(40)34-23-16-24(27(42-6)17-26(23)38(4)14-13-37(2)3)35-31-33-18-21(30(41)43-15-12-32)29(36-31)22-19-39(5)25-11-9-8-10-20(22)25/h7-11,16-19H,1,13-15H2,2-6H3,(H,34,40)(H,33,35,36)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368410
PNG
(N-(5-((5-chloro-4-(1-methyl-1,6,7,8-tetrahydrocycl...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cn(C)c2c3CCCc3ccc12
Show InChI InChI=1S/C31H36ClN7O2/c1-7-28(40)34-24-15-25(27(41-6)16-26(24)38(4)14-13-37(2)3)35-31-33-17-23(32)29(36-31)22-18-39(5)30-20-10-8-9-19(20)11-12-21(22)30/h7,11-12,15-18H,1,8-10,13-14H2,2-6H3,(H,34,40)(H,33,35,36)
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n/an/a<100n/an/an/an/an/an/a



ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM368416
PNG
(US10227342, Example 48)
Show SMILES COCC(CN(C)C)Oc1cc(OC)c(Nc2ncc(Cl)c(n2)-c2cnn3ccccc23)cc1NC(=O)C=C
Show InChI InChI=1/C27H30ClN7O4/c1-6-25(36)31-21-11-20(23(38-5)12-24(21)39-17(16-37-4)15-34(2)3)32-27-29-14-19(28)26(33-27)18-13-30-35-10-8-7-9-22(18)35/h6-14,17H,1,15-16H2,2-5H3,(H,31,36)(H,29,32,33)
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ARIAD PHARMACEUTICALS, INC.

US Patent


Assay Description
A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...


US Patent US10227342 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%