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Patent code US10227343

Compile Data Set for Download or QSAR
Found 112 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368479
PNG
(1,4-oxazepan-4-yl-[6- (1H-pyrazolo[4,3-b] pyridin-...)
Show SMILES O=C(N1CCCOCC1)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C22H21N5O2/c28-22(27-10-3-12-29-13-11-27)18-5-1-4-15-14-16(7-8-17(15)18)24-21-20-19(25-26-21)6-2-9-23-20/h1-2,4-9,14H,3,10-13H2,(H2,24,25,26)
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n/an/an/an/a 480n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368495
PNG
(4-fluoro-1-methyl-N- (1H-pyrazolo[4,3-b] pyridin-3...)
Show SMILES Cc1ncc(F)c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C16H12FN5/c1-9-11-5-4-10(7-12(11)13(17)8-19-9)20-16-15-14(21-22-16)3-2-6-18-15/h2-8H,1H3,(H2,20,21,22)
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n/an/an/an/a 13n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368504
PNG
((6-((1H-pyrazolo[4,3-b] pyridin-3-yl)amino) naphth...)
Show SMILES O=C(N1CCS(=O)(=O)CC1)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C21H19N5O3S/c27-21(26-9-11-30(28,29)12-10-26)17-4-1-3-14-13-15(6-7-16(14)17)23-20-19-18(24-25-20)5-2-8-22-19/h1-8,13H,9-12H2,(H2,23,24,25)
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n/an/an/an/a 810n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368512
PNG
(1-(1-methyl-1H-pyrazol- 5-yl)-N-(1H-pyrazolo [4,3-...)
Show SMILES Cn1nccc1-c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H15N7/c1-26-16(7-10-22-26)17-14-5-4-13(11-12(14)6-9-21-17)23-19-18-15(24-25-19)3-2-8-20-18/h2-11H,1H3,(H2,23,24,25)
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n/an/an/an/a 70n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368514
PNG
(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Show SMILES FC(F)(F)c1nccc2cc(Nc3n[nH]c4ncccc34)ccc12
Show InChI InChI=1S/C16H10F3N5/c17-16(18,19)13-11-4-3-10(8-9(11)5-7-20-13)22-15-12-2-1-6-21-14(12)23-24-15/h1-8H,(H2,21,22,23,24)
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n/an/an/an/a 67n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368523
PNG
(1-(difluoromethyl)-N- (1H-pyrazolo[3,4-b] pyrazin-...)
Show SMILES FC(F)c1nccc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C15H10F2N6/c16-13(17)11-10-2-1-9(7-8(10)3-4-18-11)21-15-12-14(22-23-15)20-6-5-19-12/h1-7,13H,(H2,20,21,22,23)
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n/an/an/an/a 13n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368529
PNG
(3-chloro-N1-(2- methoxyethyl)-N1- methyl- N6-(1H-p...)
Show SMILES COCCN(C)c1nc(Cl)cc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H19ClN6O/c1-26(8-9-27-2)19-14-6-5-13(10-12(14)11-16(20)23-19)22-18-17-15(24-25-18)4-3-7-21-17/h3-7,10-11H,8-9H2,1-2H3,(H2,22,24,25)
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n/an/an/an/a 3.19E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368530
PNG
(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-[1,2,4] triazo...)
Show SMILES N(c1n[nH]c2cccnc12)c1ccc2c3nncn3ccc2c1
Show InChI InChI=1S/C16H11N7/c1-2-13-14(17-6-1)15(21-20-13)19-11-3-4-12-10(8-11)5-7-23-9-18-22-16(12)23/h1-9H,(H2,19,20,21)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368536
PNG
(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1-(4- (pyrimid...)
Show SMILES C1CN(CCN1c1ncccn1)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C23H21N9/c1-3-19-20(24-7-1)21(30-29-19)28-17-4-5-18-16(15-17)6-10-25-22(18)31-11-13-32(14-12-31)23-26-8-2-9-27-23/h1-10,15H,11-14H2,(H2,28,29,30)
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n/an/an/an/a 171n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368539
PNG
(4-cyclopentyl-1-methyl-N- (1H-pyrazolo[4,3-b] pyri...)
Show SMILES Cc1ncc(C2CCCC2)c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C21H21N5/c1-13-16-9-8-15(24-21-20-19(25-26-21)7-4-10-22-20)11-17(16)18(12-23-13)14-5-2-3-6-14/h4,7-12,14H,2-3,5-6H2,1H3,(H2,24,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368540
PNG
(1,3,4-trimethyl-N-(1H- pyrazolo[4,3-b]pyridin-3- y...)
Show SMILES Cc1nc(C)c2ccc(Nc3n[nH]c4cccnc34)cc2c1C
Show InChI InChI=1S/C18H17N5/c1-10-11(2)20-12(3)14-7-6-13(9-15(10)14)21-18-17-16(22-23-18)5-4-8-19-17/h4-9H,1-3H3,(H2,21,22,23)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368544
PNG
(3-isopropyl-N-(1H- pyrazolo[4,3-b]pyridin-3- yl)is...)
Show SMILES CC(C)c1cc2cc(Nc3n[nH]c4cccnc34)ccc2cn1
Show InChI InChI=1S/C18H17N5/c1-11(2)16-9-13-8-14(6-5-12(13)10-20-16)21-18-17-15(22-23-18)4-3-7-19-17/h3-11H,1-2H3,(H2,21,22,23)
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n/an/an/an/a 2.39E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368552
PNG
(N-(1H-pyrazolo[4,3-b] pyridin- 3-yl)isoquinolin-6-...)
Show SMILES N(c1n[nH]c2cccnc12)c1ccc2cnccc2c1
Show InChI InChI=1S/C15H11N5/c1-2-13-14(17-6-1)15(20-19-13)18-12-4-3-11-9-16-7-5-10(11)8-12/h1-9H,(H2,18,19,20)
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n/an/an/an/a 61n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368563
PNG
((4,4-difluoro-1-piperidyl)- [6-(1H-pyrazolo[3,4-b]...)
Show SMILES FC1(F)CCN(CC1)C(=O)c1cccc2cc(Nc3n[nH]c4ncccc34)ccc12
Show InChI InChI=1S/C22H19F2N5O/c23-22(24)8-11-29(12-9-22)21(30)17-4-1-3-14-13-15(6-7-16(14)17)26-20-18-5-2-10-25-19(18)27-28-20/h1-7,10,13H,8-9,11-12H2,(H2,25,26,27,28)
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n/an/an/an/a 947n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368564
PNG
((4,4-difluoro-1-piperidyl)- [6-[(6-fluoro-1H-pyraz...)
Show SMILES Fc1cnc2c(Nc3ccc4c(cccc4c3)C(=O)N3CCC(F)(F)CC3)n[nH]c2c1
Show InChI InChI=1S/C22H18F3N5O/c23-14-11-18-19(26-12-14)20(29-28-18)27-15-4-5-16-13(10-15)2-1-3-17(16)21(31)30-8-6-22(24,25)7-9-30/h1-5,10-12H,6-9H2,(H2,27,28,29)
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n/an/an/an/a 315n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368566
PNG
((6,6-difluoro-2-azaspiro [3,3]heptan-2-yl)-[6- (1H...)
Show SMILES FC1(F)CC2(CN(C2)C(=O)c2cccc3cc(Nc4n[nH]c5cccnc45)ccc23)C1
Show InChI InChI=1S/C23H19F2N5O/c24-23(25)10-22(11-23)12-30(13-22)21(31)17-4-1-3-14-9-15(6-7-16(14)17)27-20-19-18(28-29-20)5-2-8-26-19/h1-9H,10-13H2,(H2,27,28,29)
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n/an/an/an/a 413n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368576
PNG
(1-(1-fluoro-1-methyl- ethyl)-N-(1H- pyrazolo[3,4-b...)
Show SMILES CC(C)(F)c1nccc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C17H15FN6/c1-17(2,18)14-12-4-3-11(9-10(12)5-6-20-14)22-16-13-15(23-24-16)21-8-7-19-13/h3-9H,1-2H3,(H2,21,22,23,24)
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n/an/an/an/a 8n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368425
PNG
((4- methylsulfonylpiperazin- 1-yl)-[6-(1H-pyrazolo...)
Show SMILES CS(=O)(=O)N1CCN(CC1)C(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C22H22N6O3S/c1-32(30,31)28-12-10-27(11-13-28)22(29)18-5-2-4-15-14-16(7-8-17(15)18)24-21-20-19(25-26-21)6-3-9-23-20/h2-9,14H,10-13H2,1H3,(H2,24,25,26)
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n/an/an/an/a 373n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368472
PNG
((1,1-dioxo-1,4-thiazepan- 4-yl)-[6-(1H-pyrazolo [4...)
Show SMILES O=C(N1CCCS(=O)(=O)CC1)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C22H21N5O3S/c28-22(27-10-3-12-31(29,30)13-11-27)18-5-1-4-15-14-16(7-8-17(15)18)24-21-20-19(25-26-21)6-2-9-23-20/h1-2,4-9,14H,3,10-13H2,(H2,24,25,26)
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n/an/an/an/a 1.25E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368492
PNG
(6-(1H-pyrazolo[4,3-b] pyridin-3-ylamino) naphthale...)
Show SMILES N#Cc1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C17H11N5/c18-10-12-4-1-3-11-9-13(6-7-14(11)12)20-17-16-15(21-22-17)5-2-8-19-16/h1-9H,(H2,20,21,22)
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n/an/an/an/a 422n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368507
PNG
(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1-(1H- 1,2,4- ...)
Show SMILES N(c1n[nH]c2cccnc12)c1ccc2c(nccc2c1)-n1cncn1
Show InChI InChI=1S/C17H12N8/c1-2-14-15(19-6-1)16(24-23-14)22-12-3-4-13-11(8-12)5-7-20-17(13)25-10-18-9-21-25/h1-10H,(H2,22,23,24)
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n/an/an/an/a 302n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368519
PNG
(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)tetrazolo [5,1-...)
Show SMILES N(c1n[nH]c2cccnc12)c1ccc2c3nnnn3ccc2c1
Show InChI InChI=1S/C15H10N8/c1-2-12-13(16-6-1)14(19-18-12)17-10-3-4-11-9(8-10)5-7-23-15(11)20-21-22-23/h1-8H,(H2,17,18,19)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368520
PNG
(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1- (trifluorom...)
Show SMILES FC(F)(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C16H10F3N5/c17-16(18,19)14-11-4-3-10(8-9(11)5-7-21-14)22-15-13-12(23-24-15)2-1-6-20-13/h1-8H,(H2,22,23,24)
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n/an/an/an/a 18n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368522
PNG
(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)imidazo [2,1-a]...)
Show SMILES N(c1n[nH]c2cccnc12)c1ccc2c3nccn3ccc2c1
Show InChI InChI=1S/C17H12N6/c1-2-14-15(18-6-1)16(22-21-14)20-12-3-4-13-11(10-12)5-8-23-9-7-19-17(13)23/h1-10H,(H2,20,21,22)
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UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368524
PNG
(3-chloro-1-ethyl-N-(1H- pyrazolo[4,3-b]pyridin-3- ...)
Show SMILES CCc1nc(Cl)cc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C17H14ClN5/c1-2-13-12-6-5-11(8-10(12)9-15(18)21-13)20-17-16-14(22-23-17)4-3-7-19-16/h3-9H,2H2,1H3,(H2,20,22,23)
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n/an/an/an/a 582n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368527
PNG
(3-chloro-1-methyl-N-(1H- pyrazolo[4,3-b]pyridin-3-...)
Show SMILES Cc1nc(Cl)cc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C16H12ClN5/c1-9-12-5-4-11(7-10(12)8-14(17)19-9)20-16-15-13(21-22-16)3-2-6-18-15/h2-8H,1H3,(H2,20,21,22)
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n/an/an/an/a 168n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368531
PNG
(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1-(2- (trifluo...)
Show SMILES FC(F)(F)C1CCCCN1c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1/C21H19F3N6/c22-21(23,24)17-5-1-2-11-30(17)20-15-7-6-14(12-13(15)8-10-26-20)27-19-18-16(28-29-19)4-3-9-25-18/h3-4,6-10,12,17H,1-2,5,11H2,(H2,27,28,29)
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n/an/an/an/a 306n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368535
PNG
(1-(4-methylpiperidin-1- yl)-N-(1H-pyrazolo [4,3-b]...)
Show SMILES CC1CCN(CC1)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C21H22N6/c1-14-7-11-27(12-8-14)21-17-5-4-16(13-15(17)6-10-23-21)24-20-19-18(25-26-20)3-2-9-22-19/h2-6,9-10,13-14H,7-8,11-12H2,1H3,(H2,24,25,26)
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n/an/an/an/a 219n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368546
PNG
(N-(1H-pyrazolo[3,4-b] pyrazin- 3-yl)isoquinolin-6-...)
Show SMILES N(c1n[nH]c2nccnc12)c1ccc2cnccc2c1
Show InChI InChI=1S/C14H10N6/c1-2-11(7-9-3-4-15-8-10(1)9)18-14-12-13(19-20-14)17-6-5-16-12/h1-8H,(H2,17,18,19,20)
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n/an/an/an/a 51n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368550
PNG
(N-(5,5-difluoro-4,5,6,7- tetrahydro-1H-indazol-3- ...)
Show SMILES FC1(F)CCc2[nH]nc(Nc3ccc4cnccc4c3)c2C1
Show InChI InChI=1S/C16H14F2N4/c17-16(18)5-3-14-13(8-16)15(22-21-14)20-12-2-1-11-9-19-6-4-10(11)7-12/h1-2,4,6-7,9H,3,5,8H2,(H2,20,21,22)
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n/an/an/an/a 1.50E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368504
PNG
((6-((1H-pyrazolo[4,3-b] pyridin-3-yl)amino) naphth...)
Show SMILES O=C(N1CCS(=O)(=O)CC1)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C21H19N5O3S/c27-21(26-9-11-30(28,29)12-10-26)17-4-1-3-14-13-15(6-7-16(14)17)23-20-19-18(24-25-20)5-2-8-22-19/h1-8,13H,9-12H2,(H2,23,24,25)
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n/an/an/an/a 699n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368562
PNG
((4,4-difluoro-1-piperidyl)- [6-(1H-pyrazolo[3,4-b]...)
Show SMILES FC1(F)CCN(CC1)C(=O)c1cccc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C21H18F2N6O/c22-21(23)6-10-29(11-7-21)20(30)16-3-1-2-13-12-14(4-5-15(13)16)26-19-17-18(27-28-19)25-9-8-24-17/h1-5,8-9,12H,6-7,10-11H2,(H2,25,26,27,28)
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n/an/an/an/a 154n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368424
PNG
(N-(3,3- difluorocycloburyl)- 6-(1H-pyrazolo[4,3-b]...)
Show SMILES FC1(F)CC(C1)NC(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C21H17F2N5O/c22-21(23)10-14(11-21)26-20(29)16-4-1-3-12-9-13(6-7-15(12)16)25-19-18-17(27-28-19)5-2-8-24-18/h1-9,14H,10-11H2,(H,26,29)(H2,25,27,28)
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n/an/an/an/a 45n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368473
PNG
((3- methylsulfonylpyrrolidin- 1-yl)-[6-(1H-pyrazol...)
Show SMILES CS(=O)(=O)C1CCN(C1)C(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1/C22H21N5O3S/c1-31(29,30)16-9-11-27(13-16)22(28)18-5-2-4-14-12-15(7-8-17(14)18)24-21-20-19(25-26-21)6-3-10-23-20/h2-8,10,12,16H,9,11,13H2,1H3,(H2,24,25,26)
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n/an/an/an/a 2.87E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368475
PNG
(N-(2- methylsulfonylethyl)- 6-(1H-pyrazolo[4,3-b] ...)
Show SMILES CS(=O)(=O)CCNC(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C20H19N5O3S/c1-29(27,28)11-10-22-20(26)16-5-2-4-13-12-14(7-8-15(13)16)23-19-18-17(24-25-19)6-3-9-21-18/h2-9,12H,10-11H2,1H3,(H,22,26)(H2,23,24,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368485
PNG
(N-(1H-pyrazolo[3,4-b] pyrazin-3-yl)-1- (tetrahydro...)
Show SMILES C(Oc1nccc2cc(Nc3n[nH]c4nccnc34)ccc12)C1CCCCO1
Show InChI InChI=1/C20H20N6O2/c1-2-10-27-15(3-1)12-28-20-16-5-4-14(11-13(16)6-7-23-20)24-19-17-18(25-26-19)22-9-8-21-17/h4-9,11,15H,1-3,10,12H2,(H2,22,24,25,26)
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n/an/an/an/a 70n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368500
PNG
(4-fluoro-N-(1H-pyrazolo [4,3-b]pyridin-3-yl)-1- py...)
Show SMILES Fc1cnc(-n2cccn2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C18H12FN7/c19-14-10-21-18(26-8-2-7-22-26)12-5-4-11(9-13(12)14)23-17-16-15(24-25-17)3-1-6-20-16/h1-10H,(H2,23,24,25)
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n/an/an/an/a 102n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368511
PNG
(1-(1-methyl-3- (trifluoromethyl)-1H- pyrazol-5-yl)...)
Show SMILES Cn1nc(cc1-c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12)C(F)(F)F
Show InChI InChI=1S/C20H14F3N7/c1-30-15(10-16(29-30)20(21,22)23)17-13-5-4-12(9-11(13)6-8-25-17)26-19-18-14(27-28-19)3-2-7-24-18/h2-10H,1H3,(H2,26,27,28)
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n/an/an/an/a 132n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368513
PNG
(1-chloro-4-fluoro-N- (1H-pyrazolo[4,3-b] pyridin-3...)
Show SMILES Fc1cnc(Cl)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C15H9ClFN5/c16-14-9-4-3-8(6-10(9)11(17)7-19-14)20-15-13-12(21-22-15)2-1-5-18-13/h1-7H,(H2,20,21,22)
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n/an/an/an/a 15n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368516
PNG
(1-(3,3-difluoroazetidin- 1-yl)-N-(1H- pyrazolin[4,...)
Show SMILES FC1(F)CN(C1)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C18H14F2N6/c19-18(20)9-26(10-18)17-13-4-3-12(8-11(13)5-7-22-17)23-16-15-14(24-25-16)2-1-6-21-15/h1-8H,9-10H2,(H2,23,24,25)
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n/an/an/an/a 52n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368517
PNG
(1,4-dichloro-N-(1H- pyrazolo[4,3-b]pyridin-3- yl)i...)
Show SMILES Clc1cnc(Cl)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C15H9Cl2N5/c16-11-7-19-14(17)9-4-3-8(6-10(9)11)20-15-13-12(21-22-15)2-1-5-18-13/h1-7H,(H2,20,21,22)
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n/an/an/an/a 76n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368538
PNG
(N1-(2-methoxyethyl)-N1- methyl-N6-(1H-pyrazolo [4,...)
Show SMILES COCCN(C)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H20N6O/c1-25(10-11-26-2)19-15-6-5-14(12-13(15)7-9-21-19)22-18-17-16(23-24-18)4-3-8-20-17/h3-9,12H,10-11H2,1-2H3,(H2,22,23,24)
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n/an/an/an/a 81n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368543
PNG
(1-(piperidin-1-yl)-N-(1H- pyrazolo[4,3-b]pyridin-3...)
Show SMILES C1CCN(CC1)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C20H20N6/c1-2-11-26(12-3-1)20-16-7-6-15(13-14(16)8-10-22-20)23-19-18-17(24-25-19)5-4-9-21-18/h4-10,13H,1-3,11-12H2,(H2,23,24,25)
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n/an/an/an/a 215n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368545
PNG
(1-morpholino-N-(1H- pyrazolo[4,3-b]pyridin-3- yl)i...)
Show SMILES C1CN(CCO1)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H18N6O/c1-2-16-17(20-6-1)18(24-23-16)22-14-3-4-15-13(12-14)5-7-21-19(15)25-8-10-26-11-9-25/h1-7,12H,8-11H2,(H2,22,23,24)
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n/an/an/an/a 215n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368553
PNG
(N-(naphthalen-2-yl)-1H- pyrazolo[4,3-b]pyridin-3- ...)
Show SMILES N(c1n[nH]c2cccnc12)c1ccc2ccccc2c1
Show InChI InChI=1S/C16H12N4/c1-2-5-12-10-13(8-7-11(12)4-1)18-16-15-14(19-20-16)6-3-9-17-15/h1-10H,(H2,18,19,20)
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n/an/an/an/a 403n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368516
PNG
(1-(3,3-difluoroazetidin- 1-yl)-N-(1H- pyrazolin[4,...)
Show SMILES FC1(F)CN(C1)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C18H14F2N6/c19-18(20)9-26(10-18)17-13-4-3-12(8-11(13)5-7-22-17)23-16-15-14(24-25-16)2-1-6-21-15/h1-8H,9-10H2,(H2,23,24,25)
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n/an/an/an/a 51.6n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368572
PNG
(1-(1,1-difluorobutyl)-N- (1H- pyrazolo[4,3-b]pyrid...)
Show SMILES CCCC(F)(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H17F2N5/c1-2-8-19(20,21)17-14-6-5-13(11-12(14)7-10-23-17)24-18-16-15(25-26-18)4-3-9-22-16/h3-7,9-11H,2,8H2,1H3,(H2,24,25,26)
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n/an/an/an/a 34.4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368420
PNG
(N-(3- fluorocyclobutyl)-6- (1H-pyrazolo[4,3-b] pyr...)
Show SMILES FC1CC(C1)NC(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C21H18FN5O/c22-13-10-15(11-13)25-21(28)17-4-1-3-12-9-14(6-7-16(12)17)24-20-19-18(26-27-20)5-2-8-23-19/h1-9,13,15H,10-11H2,(H,25,28)(H2,24,26,27)
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n/an/an/an/a 270n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368480
PNG
((4-methylpiperazin-1- yl)-[6-(1H-pyrazolo [4,3-b]p...)
Show SMILES CN1CCN(CC1)C(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C22H22N6O/c1-27-10-12-28(13-11-27)22(29)18-5-2-4-15-14-16(7-8-17(15)18)24-21-20-19(25-26-21)6-3-9-23-20/h2-9,14H,10-13H2,1H3,(H2,24,25,26)
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n/an/an/an/a 2.32E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368487
PNG
(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1- (tetrahydro...)
Show SMILES C(Oc1nccc2cc(Nc3n[nH]c4cccnc34)ccc12)C1CCCCO1
Show InChI InChI=1/C21H21N5O2/c1-2-11-27-16(4-1)13-28-21-17-7-6-15(12-14(17)8-10-23-21)24-20-19-18(25-26-20)5-3-9-22-19/h3,5-10,12,16H,1-2,4,11,13H2,(H2,24,25,26)
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n/an/an/an/a 79n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368518
PNG
(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1-(1,1,1- trif...)
Show SMILES CC(c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12)C(F)(F)F
Show InChI InChI=1/C18H14F3N5/c1-10(18(19,20)21)15-13-5-4-12(9-11(13)6-8-23-15)24-17-16-14(25-26-17)3-2-7-22-16/h2-10H,1H3,(H2,24,25,26)
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n/an/an/an/a 42n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368528
PNG
(3-chloro-N1,N1-diethyl- N6-(1H-pyrazolo [4,3-b]pyr...)
Show SMILES CCN(CC)c1nc(Cl)cc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H19ClN6/c1-3-26(4-2)19-14-8-7-13(10-12(14)11-16(20)23-19)22-18-17-15(24-25-18)6-5-9-21-17/h5-11H,3-4H2,1-2H3,(H2,22,24,25)
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n/an/an/an/a 3.32E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368533
PNG
(1-(tert-butyl)-N-(1H- pyrazolo[4,3-b]pyridin-3- yl...)
Show SMILES CC(C)(C)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H19N5/c1-19(2,3)17-14-7-6-13(11-12(14)8-10-21-17)22-18-16-15(23-24-18)5-4-9-20-16/h4-11H,1-3H3,(H2,22,23,24)
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n/an/an/an/a 287n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368542
PNG
(1-(1H-pyrazol-1-yl)-N- (1H- pyrazolo[4,3-b]pyridin...)
Show SMILES N(c1n[nH]c2cccnc12)c1ccc2c(nccc2c1)-n1cccn1
Show InChI InChI=1S/C18H13N7/c1-3-15-16(19-7-1)17(24-23-15)22-13-4-5-14-12(11-13)6-9-20-18(14)25-10-2-8-21-25/h1-11H,(H2,22,23,24)
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n/an/an/an/a 63n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM186254
PNG
(US10227343, Example 83 | US9163015, 40)
Show SMILES N(c1n[nH]c2cccnc12)c1cnc2ccccc2c1
Show InChI InChI=1S/C15H11N5/c1-2-5-12-10(4-1)8-11(9-17-12)18-15-14-13(19-20-15)6-3-7-16-14/h1-9H,(H2,18,19,20)
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US Patent
n/an/an/an/a 873n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368505
PNG
((6-((1H-pyrazolo[4,3- b]pyridin-3- yl)amino)naphth...)
Show SMILES O=C(N1CCOCC1)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C21H19N5O2/c27-21(26-9-11-28-12-10-26)17-4-1-3-14-13-15(6-7-16(14)17)23-20-19-18(24-25-20)5-2-8-22-19/h1-8,13H,9-12H2,(H2,23,24,25)
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n/an/an/an/a 625n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368567
PNG
(N-(3,3- difluorocyclobutyl)-N- methyl-6-(1H-pyrazo...)
Show SMILES CN(C1CC(F)(F)C1)C(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C22H19F2N5O/c1-29(15-11-22(23,24)12-15)21(30)17-5-2-4-13-10-14(7-8-16(13)17)26-20-19-18(27-28-20)6-3-9-25-19/h2-10,15H,11-12H2,1H3,(H2,26,27,28)
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n/an/an/an/a 1.01E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368569
PNG
(1-(1,1-difluoroethyl)-N- (1H- pyrazolo[4,3-b]pyrid...)
Show SMILES CC(F)(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C17H13F2N5/c1-17(18,19)15-12-5-4-11(9-10(12)6-8-21-15)22-16-14-13(23-24-16)3-2-7-20-14/h2-9H,1H3,(H2,22,23,24)
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n/an/an/an/a 20.1n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368575
PNG
(1-(1-fluoro-1-methyl- ethyl)- N-(1H-pyrazolo[3,4-b...)
Show SMILES CC(C)(F)c1nccc2cc(Nc3n[nH]c4ncccc34)ccc12
Show InChI InChI=1S/C18H16FN5/c1-18(2,19)15-13-6-5-12(10-11(13)7-9-20-15)22-17-14-4-3-8-21-16(14)23-24-17/h3-10H,1-2H3,(H2,21,22,23,24)
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n/an/an/an/a 38.8n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368579
PNG
(N-(6-fluoro-1H-pyrazolo [4,3-b]pyridin-3-yl)-1- (t...)
Show SMILES Fc1cnc2c(Nc3ccc4c(nccc4c3)C(F)(F)F)n[nH]c2c1
Show InChI InChI=1S/C16H9F4N5/c17-9-6-12-13(22-7-9)15(25-24-12)23-10-1-2-11-8(5-10)3-4-21-14(11)16(18,19)20/h1-7H,(H2,23,24,25)
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n/an/an/an/a 38.5n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368391
PNG
(N-(3- methylsulfonylpropyl)- 6-(1H-pyrazolo [4,3-b...)
Show SMILES CS(=O)(=O)CCCNC(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C21H21N5O3S/c1-30(28,29)12-4-11-23-21(27)17-6-2-5-14-13-15(8-9-16(14)17)24-20-19-18(25-26-20)7-3-10-22-19/h2-3,5-10,13H,4,11-12H2,1H3,(H,23,27)(H2,24,25,26)
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n/an/an/an/a 7.00E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368481
PNG
((3,3-difluoro-1- piperidyl)-[6-(1H- pyrazolo[4,3-b...)
Show SMILES FC1(F)CCCN(C1)C(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C22H19F2N5O/c23-22(24)9-3-11-29(13-22)21(30)17-5-1-4-14-12-15(7-8-16(14)17)26-20-19-18(27-28-20)6-2-10-25-19/h1-2,4-8,10,12H,3,9,11,13H2,(H2,26,27,28)
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n/an/an/an/a 498n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368489
PNG
(1-[2-(dimethylamino) ethoxy]-N-(1H-pyrazolo [4,3-b...)
Show SMILES CN(C)CCOc1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H20N6O/c1-25(2)10-11-26-19-15-6-5-14(12-13(15)7-9-21-19)22-18-17-16(23-24-18)4-3-8-20-17/h3-9,12H,10-11H2,1-2H3,(H2,22,23,24)
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n/an/an/an/a 649n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368501
PNG
(1-cyclopropyl-4-fluoro- N-(1H-pyrazolo[4,3-b] pyri...)
Show SMILES Fc1cnc(C2CC2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C18H14FN5/c19-14-9-21-16(10-3-4-10)12-6-5-11(8-13(12)14)22-18-17-15(23-24-18)2-1-7-20-17/h1-2,5-10H,3-4H2,(H2,22,23,24)
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n/an/an/an/a 28n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368505
PNG
((6-((1H-pyrazolo[4,3- b]pyridin-3- yl)amino)naphth...)
Show SMILES O=C(N1CCOCC1)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C21H19N5O2/c27-21(26-9-11-28-12-10-26)17-4-1-3-14-13-15(6-7-16(14)17)23-20-19-18(24-25-20)5-2-8-22-19/h1-8,13H,9-12H2,(H2,23,24,25)
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n/an/an/an/a 625n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368509
PNG
(1-(3-methyl-4- (trifluoromethyl)-4,5- dihydroisoxa...)
Show SMILES CC1=NOCC1(c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12)C(F)(F)F
Show InChI InChI=1/C20H15F3N6O/c1-11-19(10-30-29-11,20(21,22)23)17-14-5-4-13(9-12(14)6-8-25-17)26-18-16-15(27-28-18)3-2-7-24-16/h2-9H,10H2,1H3,(H2,26,27,28)
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n/an/an/an/a 49n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368515
PNG
(N-(1H-pyrazolo[3,4- b]pyrazin-3-yl)-1- (trifluorom...)
Show SMILES FC(F)(F)c1nccc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C15H9F3N6/c16-15(17,18)12-10-2-1-9(7-8(10)3-4-20-12)22-14-11-13(23-24-14)21-6-5-19-11/h1-7H,(H2,21,22,23,24)
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n/an/an/an/a 31n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368534
PNG
(1-(2-methylpiperidin-1- yl)-N-(1H-pyrazolo [4,3-b]...)
Show SMILES CC1CCCCN1c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1/C21H22N6/c1-14-5-2-3-12-27(14)21-17-8-7-16(13-15(17)9-11-23-21)24-20-19-18(25-26-20)6-4-10-22-19/h4,6-11,13-14H,2-3,5,12H2,1H3,(H2,24,25,26)
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n/an/an/an/a 386n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368537
PNG
(1-(3,3-difluoropyrrolidin- 1-yl)-N-(1H- pyrazolo[4...)
Show SMILES FC1(F)CCN(C1)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H16F2N6/c20-19(21)6-9-27(11-19)18-14-4-3-13(10-12(14)5-8-23-18)24-17-16-15(25-26-17)2-1-7-22-16/h1-5,7-8,10H,6,9,11H2,(H2,24,25,26)
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n/an/an/an/a 249n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368549
PNG
(1-ethyl-N-(1H-pyrazolo [4,3-b]pyridin- 3-yl)isoqui...)
Show SMILES CCc1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C17H15N5/c1-2-14-13-6-5-12(10-11(13)7-9-18-14)20-17-16-15(21-22-17)4-3-8-19-16/h3-10H,2H2,1H3,(H2,20,21,22)
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n/an/an/an/a 47n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368557
PNG
(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1-(3,3,3- trif...)
Show SMILES FC(F)(F)C(=C)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C18H12F3N5/c1-10(18(19,20)21)15-13-5-4-12(9-11(13)6-8-23-15)24-17-16-14(25-26-17)3-2-7-22-16/h2-9H,1H2,(H2,24,25,26)
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n/an/an/an/a 61.4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368565
PNG
((4,4-difluoro-1-piperidyl)- [6-[(5-fluoro-1H-pyraz...)
Show SMILES Fc1cnc2[nH]nc(Nc3ccc4c(cccc4c3)C(=O)N3CCC(F)(F)CC3)c2c1
Show InChI InChI=1S/C22H18F3N5O/c23-14-11-18-19(26-12-14)28-29-20(18)27-15-4-5-16-13(10-15)2-1-3-17(16)21(31)30-8-6-22(24,25)7-9-30/h1-5,10-12H,6-9H2,(H2,26,27,28,29)
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n/an/an/an/a 981n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368474
PNG
(US10227343, Example 9 | piperazin-1-yl-[6-(1H- pyr...)
Show SMILES O=C(N1CCNCC1)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C21H20N6O/c28-21(27-11-9-22-10-12-27)17-4-1-3-14-13-15(6-7-16(14)17)24-20-19-18(25-26-20)5-2-8-23-19/h1-8,13,22H,9-12H2,(H2,24,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368484
PNG
((4-fluoro-1-piperidyl)-[6- (1H-pyrazolo[4,3-b] pyr...)
Show SMILES FC1CCN(CC1)C(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C22H20FN5O/c23-15-8-11-28(12-9-15)22(29)18-4-1-3-14-13-16(6-7-17(14)18)25-21-20-19(26-27-21)5-2-10-24-20/h1-7,10,13,15H,8-9,11-12H2,(H2,25,26,27)
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n/an/an/an/a 339n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368488
PNG
(1-[2-(dimethylamino) ethoxy]-N-(1H-pyrazolo [3,4-b...)
Show SMILES CN(C)CCOc1nccc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C18H19N7O/c1-25(2)9-10-26-18-14-4-3-13(11-12(14)5-6-21-18)22-17-15-16(23-24-17)20-8-7-19-15/h3-8,11H,9-10H2,1-2H3,(H2,20,22,23,24)
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n/an/an/an/a 875n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368502
PNG
(4-fluoro-1-(5-fluoro-3- pyridyl)-N-(1H-pyrazolo [4...)
Show SMILES Fc1cncc(c1)-c1ncc(F)c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C20H12F2N6/c21-12-6-11(8-23-9-12)18-14-4-3-13(7-15(14)16(22)10-25-18)26-20-19-17(27-28-20)2-1-5-24-19/h1-10H,(H2,26,27,28)
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n/an/an/an/a 105n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368559
PNG
(N1-methyl-N6-(1H- pyrazolo [4,3-b]pyridin-3-yl)-N1...)
Show SMILES CN(CC(F)(F)F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C18H15F3N6/c1-27(10-18(19,20)21)17-13-5-4-12(9-11(13)6-8-23-17)24-16-15-14(25-26-16)3-2-7-22-15/h2-9H,10H2,1H3,(H2,24,25,26)
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n/an/an/an/a 56.1n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368577
PNG
(1-(1-fluoro-1-methyl- ethyl)- N-(1H-pyrazolo[4,3-b...)
Show SMILES CC(C)(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C18H16FN5/c1-18(2,19)16-13-6-5-12(10-11(13)7-9-21-16)22-17-15-14(23-24-17)4-3-8-20-15/h3-10H,1-2H3,(H2,22,23,24)
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n/an/an/an/a 23.1n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368578
PNG
(1-(1,1-difluoro-2-methyl- propyl)-N-(1H-pyrazolo [...)
Show SMILES CC(C)C(F)(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H17F2N5/c1-11(2)19(20,21)17-14-6-5-13(10-12(14)7-9-23-17)24-18-16-15(25-26-18)4-3-8-22-16/h3-11H,1-2H3,(H2,24,25,26)
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n/an/an/an/a 31.4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368390
PNG
(1-[4-[6-(1H-pyrazolo [4,3-b]-pyridin-3- ylamino)na...)
Show SMILES CC(=O)N1CCN(CC1)C(=O)c1cccc2cc(Nc3n[nH]c4ccccc34)ccc12
Show InChI InChI=1S/C24H23N5O2/c1-16(30)28-11-13-29(14-12-28)24(31)20-7-4-5-17-15-18(9-10-19(17)20)25-23-21-6-2-3-8-22(21)26-27-23/h2-10,15H,11-14H2,1H3,(H2,25,26,27)
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n/an/an/an/a 698n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368392
PNG
(US10227343, Example 3 | [(3S)-3- fluoropyrrolidin-...)
Show SMILES F[C@H]1CCN(C1)C(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1/C21H18FN5O/c22-14-8-10-27(12-14)21(28)17-4-1-3-13-11-15(6-7-16(13)17)24-20-19-18(25-26-20)5-2-9-23-19/h1-7,9,11,14H,8,10,12H2,(H2,24,25,26)/t14-/s2
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n/an/an/an/a 630n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368476
PNG
(US10227343, Example 11 | [(3R)-3- fluoropyrrolidin...)
Show SMILES F[C@@H]1CCN(C1)C(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1/C21H18FN5O/c22-14-8-10-27(12-14)21(28)17-4-1-3-13-11-15(6-7-16(13)17)24-20-19-18(25-26-20)5-2-9-23-19/h1-7,9,11,14H,8,10,12H2,(H2,24,25,26)/t14-/s2
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n/an/an/an/a 1.02E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368477
PNG
((3,3-difluoropyrrolidin- 1-yl)-[6-(1H-pyrazolo [4,...)
Show SMILES FC1(F)CCN(C1)C(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C21H17F2N5O/c22-21(23)8-10-28(12-21)20(29)16-4-1-3-13-11-14(6-7-15(13)16)25-19-18-17(26-27-19)5-2-9-24-18/h1-7,9,11H,8,10,12H2,(H2,25,26,27)
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n/an/an/an/a 497n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368478
PNG
(1-[6-(1H-ppyrazolo[4,3- b]pyridin-3-ylamino) napht...)
Show SMILES NC(=O)C1CCN(CC1)C(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C23H22N6O2/c24-21(30)14-8-11-29(12-9-14)23(31)18-4-1-3-15-13-16(6-7-17(15)18)26-22-20-19(27-28-22)5-2-10-25-20/h1-7,10,13-14H,8-9,11-12H2,(H2,24,30)(H2,26,27,28)
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n/an/an/an/a 2.56E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368482
PNG
((3-fluoro-1-piperidyl)- [6-(1H-pyrazolo[4,3-b] pyr...)
Show SMILES FC1CCCN(C1)C(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1/C22H20FN5O/c23-15-5-3-11-28(13-15)22(29)18-6-1-4-14-12-16(8-9-17(14)18)25-21-20-19(26-27-21)7-2-10-24-20/h1-2,4,6-10,12,15H,3,5,11,13H2,(H2,25,26,27)
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n/an/an/an/a 535n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368490
PNG
(6-(1H-pyrazolo[4,3-b] pyridin-3-ylamino)-1- (trifl...)
Show SMILES Oc1cnc(c2ccc(Nc3n[nH]c4cccnc34)cc12)C(F)(F)F
Show InChI InChI=1S/C16H10F3N5O/c17-16(18,19)14-9-4-3-8(6-10(9)12(25)7-21-14)22-15-13-11(23-24-15)2-1-5-20-13/h1-7,25H,(H2,22,23,24)
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n/an/an/an/a 1.35E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368491
PNG
(1-ethoxy-N-(1H-pyrazolo [4,3-b]pyridin-3-yl) isoqu...)
Show SMILES CCOc1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C17H15N5O/c1-2-23-17-13-6-5-12(10-11(13)7-9-19-17)20-16-15-14(21-22-16)4-3-8-18-15/h3-10H,2H2,1H3,(H2,20,21,22)
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n/an/an/an/a 33n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368493
PNG
(1-(2-methylpyrazol-3- yl)-N-(1H-pyrazolo [3,4-b]py...)
Show SMILES Cn1nccc1-c1nccc2cc(Nc3n[nH]c4ncccc34)ccc12
Show InChI InChI=1S/C19H15N7/c1-26-16(7-10-22-26)17-14-5-4-13(11-12(14)6-9-20-17)23-19-15-3-2-8-21-18(15)24-25-19/h2-11H,1H3,(H2,21,23,24,25)
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n/an/an/an/a 379n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368498
PNG
(1-(fluoromethyl)-N-(1H- pyrazolo[4,3-b]pyridin- 3-...)
Show SMILES FCc1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C16H12FN5/c17-9-14-12-4-3-11(8-10(12)5-7-18-14)20-16-15-13(21-22-16)2-1-6-19-15/h1-8H,9H2,(H2,20,21,22)
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n/an/an/an/a 44n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368499
PNG
(1-(fluoromethyl)-N-(1H- pyrazolo[3,4-b]pyridin- 3-...)
Show SMILES FCc1nccc2cc(Nc3n[nH]c4ncccc34)ccc12
Show InChI InChI=1S/C16H12FN5/c17-9-14-12-4-3-11(8-10(12)5-7-18-14)20-16-13-2-1-6-19-15(13)21-22-16/h1-8H,9H2,(H2,19,20,21,22)
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n/an/an/an/a 323n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368503
PNG
(4-fluoro-N-(1H-pyrazolo- [4,3-b]pyridin-3-yl)-1- (...)
Show SMILES Fc1cnc(C(=C)C(F)(F)F)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C18H11F4N5/c1-9(18(20,21)22)15-11-5-4-10(7-12(11)13(19)8-24-15)25-17-16-14(26-27-17)3-2-6-23-16/h2-8H,1H2,(H2,25,26,27)
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n/an/an/an/a 51n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368508
PNG
(1-ethyl-4-fluoro-N-(1H- pyrazolo[4,3-b]pyridin-3 y...)
Show SMILES CCc1ncc(F)c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C17H14FN5/c1-2-14-11-6-5-10(8-12(11)13(18)9-20-14)21-17-16-15(22-23-17)4-3-7-19-16/h3-9H,2H2,1H3,(H2,21,22,23)
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n/an/an/an/a 22n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368521
PNG
(1-(3,5-dimethyl-1H- pyrazol-1-yl)-N- (1H-pyrazolo[...)
Show SMILES Cc1cc(C)n(n1)-c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C20H17N7/c1-12-10-13(2)27(26-12)20-16-6-5-15(11-14(16)7-9-22-20)23-19-18-17(24-25-19)4-3-8-21-18/h3-11H,1-2H3,(H2,23,24,25)
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n/an/an/an/a 171n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368525
PNG
(1-(difluoromethyl)-N- (1H-pyrazolo [3,4-b]pyrazin-...)
Show SMILES FC(F)c1nccc2cc(Nc3n[nH]c4ncccc34)ccc12
Show InChI InChI=1S/C16H11F2N5/c17-14(18)13-11-4-3-10(8-9(11)5-7-19-13)21-16-12-2-1-6-20-15(12)22-23-16/h1-8,14H,(H2,20,21,22,23)
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n/an/an/an/a 43n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368541
PNG
(N1,N1-diethyl-N6-(1H- pyrazolo[4,3-b]pyridin-3- yl...)
Show SMILES CCN(CC)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H20N6/c1-3-25(4-2)19-15-8-7-14(12-13(15)9-11-21-19)22-18-17-16(23-24-18)6-5-10-20-17/h5-12H,3-4H2,1-2H3,(H2,22,23,24)
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n/an/an/an/a 164n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368547
PNG
(3-chloro-N-(1H-pyrazolo [4,3-b]pyridin-3-yl) isoqu...)
Show SMILES Clc1cc2cc(Nc3n[nH]c4cccnc34)ccc2cn1
Show InChI InChI=1S/C15H10ClN5/c16-13-7-10-6-11(4-3-9(10)8-18-13)19-15-14-12(20-21-15)2-1-5-17-14/h1-8H,(H2,19,20,21)
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n/an/an/an/a 203n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368548
PNG
(1-cyclopropyl-N-(1H- pyrazolo[4,3-b]pyridin-3- yl)...)
Show SMILES C1CC1c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C18H15N5/c1-2-15-17(19-8-1)18(23-22-15)21-13-5-6-14-12(10-13)7-9-20-16(14)11-3-4-11/h1-2,5-11H,3-4H2,(H2,21,22,23)
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n/an/an/an/a 64n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368554
PNG
(N-(1H-indazol-3- yl)isoquinolin-6-amine | US102273...)
Show SMILES N(c1n[nH]c2ccccc12)c1ccc2cnccc2c1
Show InChI InChI=1S/C16H12N4/c1-2-4-15-14(3-1)16(20-19-15)18-13-6-5-12-10-17-8-7-11(12)9-13/h1-10H,(H2,18,19,20)
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US Patent
n/an/an/an/a 165n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368555
PNG
(1-chloro-N-(1H-pyrazolo [4,3-b]pyridin-3-yl) isoqu...)
Show SMILES Clc1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C15H10ClN5/c16-14-11-4-3-10(8-9(11)5-7-18-14)19-15-13-12(20-21-15)2-1-6-17-13/h1-8H,(H2,19,20,21)
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n/an/an/an/a 80.8n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368570
PNG
(1-(1,1-difluoroethyl)-N- (1H- pyrazolo[3,4-b]pyrid...)
Show SMILES CC(F)(F)c1nccc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C16H12F2N6/c1-16(17,18)13-11-3-2-10(8-9(11)4-5-20-13)22-15-12-14(23-24-15)21-7-6-19-12/h2-8H,1H3,(H2,21,22,23,24)
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n/an/an/an/a 13.8n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368571
PNG
(2-[6-(1H-pyrazolo[3,4- b]pyridin-3-ylamino)-1- iso...)
Show SMILES CC(C)(O)c1nccc2cc(Nc3n[nH]c4ncccc34)ccc12
Show InChI InChI=1S/C18H17N5O/c1-18(2,24)15-13-6-5-12(10-11(13)7-9-19-15)21-17-14-4-3-8-20-16(14)22-23-17/h3-10,24H,1-2H3,(H2,20,21,22,23)
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n/an/an/an/a 829n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368573
PNG
(1-(1,1-difluoroburyl)-N- (1H- pyrazolo[3,4-b]pyrid...)
Show SMILES CCCC(F)(F)c1nccc2cc(Nc3n[nH]c4ncccc34)ccc12
Show InChI InChI=1S/C19H17F2N5/c1-2-8-19(20,21)16-14-6-5-13(11-12(14)7-10-22-16)24-18-15-4-3-9-23-17(15)25-26-18/h3-7,9-11H,2,8H2,1H3,(H2,23,24,25,26)
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n/an/an/an/a 110n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368580
PNG
(N-(5-fluoro-1H-pyrazolo [3,4-b]pyridin-3-yl)-1- (t...)
Show SMILES Fc1cnc2[nH]nc(Nc3ccc4c(nccc4c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C16H9F4N5/c17-9-6-12-14(22-7-9)24-25-15(12)23-10-1-2-11-8(5-10)3-4-21-13(11)16(18,19)20/h1-7H,(H2,22,23,24,25)
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n/an/an/an/a 59.5n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368483
PNG
((4,4-difluoro-1- piperidyl)-[6- (1H-pyrazolo[4,3-b...)
Show SMILES FC1(F)CCN(CC1)C(=O)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C22H19F2N5O/c23-22(24)8-11-29(12-9-22)21(30)17-4-1-3-14-13-15(6-7-16(14)17)26-20-19-18(27-28-20)5-2-10-25-19/h1-7,10,13H,8-9,11-12H2,(H2,26,27,28)
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n/an/an/an/a 303n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368486
PNG
(1-(2,2-dimethylpropoxy)- N-(1H-pyrazolo[4,3-b] pyr...)
Show SMILES CC(C)(C)COc1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C20H21N5O/c1-20(2,3)12-26-19-15-7-6-14(11-13(15)8-10-22-19)23-18-17-16(24-25-18)5-4-9-21-17/h4-11H,12H2,1-3H3,(H2,23,24,25)
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n/an/an/an/a 445n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368494
PNG
(4-fluoro-1-(2-furyl)-N- (1H-pyrazolo[4,3-b] pyridi...)
Show SMILES Fc1cnc(-c2ccco2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C19H12FN5O/c20-14-10-22-17(16-4-2-8-26-16)12-6-5-11(9-13(12)14)23-19-18-15(24-25-19)3-1-7-21-18/h1-10H,(H2,23,24,25)
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n/an/an/an/a 28n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368506
PNG
(N1-methyl-N6-(1H- pyrazolo [4,3-b]pyridin-3-yl)-N1...)
Show SMILES CN(CC(F)(F)F)c1cccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H16F3N5/c1-27(11-19(20,21)22)16-6-2-4-12-10-13(7-8-14(12)16)24-18-17-15(25-26-18)5-3-9-23-17/h2-10H,11H2,1H3,(H2,24,25,26)
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n/an/an/an/a 56n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368526
PNG
(1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...)
Show SMILES FC(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C16H11F2N5/c17-15(18)13-11-4-3-10(8-9(11)5-7-20-13)21-16-14-12(22-23-16)2-1-6-19-14/h1-8,15H,(H2,21,22,23)
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n/an/an/an/a 8n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368532
PNG
(1,3-dichloro-N-(1H- pyrazolo[4,3-b]pyridin-3- yl)i...)
Show SMILES Clc1cc2cc(Nc3n[nH]c4cccnc34)ccc2c(Cl)n1
Show InChI InChI=1S/C15H9Cl2N5/c16-12-7-8-6-9(3-4-10(8)14(17)20-12)19-15-13-11(21-22-15)2-1-5-18-13/h1-7H,(H2,19,21,22)
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n/an/an/an/a 1.88E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368556
PNG
(8-methyl-N-(1H-pyrazolo [4,3-b]pyridin-3-yl) isoqu...)
Show SMILES Cc1cc(Nc2n[nH]c3cccnc23)cc2ccncc12
Show InChI InChI=1S/C16H13N5/c1-10-7-12(8-11-4-6-17-9-13(10)11)19-16-15-14(20-21-16)3-2-5-18-15/h2-9H,1H3,(H2,19,20,21)
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n/an/an/an/a 279n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368568
PNG
(1-(1,1-difluoroethyl)-N- (1H- pyrazolo[3,4-b]pyrid...)
Show SMILES CC(F)(F)c1nccc2cc(Nc3n[nH]c4ncccc34)ccc12
Show InChI InChI=1S/C17H13F2N5/c1-17(18,19)14-12-5-4-11(9-10(12)6-8-20-14)22-16-13-3-2-7-21-15(13)23-24-16/h2-9H,1H3,(H2,21,22,23,24)
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n/an/an/an/a 51.8n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368574
PNG
(1-(1,1-difluoroburyl)-N- (1H- pyrazolo[3,4-b]pyraz...)
Show SMILES CCCC(F)(F)c1nccc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C18H16F2N6/c1-2-6-18(19,20)15-13-4-3-12(10-11(13)5-7-22-15)24-17-14-16(25-26-17)23-9-8-21-14/h3-5,7-10H,2,6H2,1H3,(H2,23,24,25,26)
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n/an/an/an/a 28.6n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%