BindingDB logo
myBDB logout

Patent code US10227350

Compile Data Set for Download or QSAR
Found 167 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368706
PNG
(US10227350, Compound 121 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(Cl)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14Cl2N8/c1-13-33-23-17(25-31-12-32-34-25)9-15(14-4-6-29-16(8-14)11-28)10-21(23)35(13)20-5-7-30-24-19(27)3-2-18(26)22(20)24/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368716
PNG
(US10227350, Compound 131 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cccc(F)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H15FN8/c1-14-32-24-18(25-30-13-31-33-25)10-16(15-5-7-28-17(9-15)12-27)11-22(24)34(14)21-6-8-29-20-4-2-3-19(26)23(20)21/h2-11,13H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368718
PNG
(US10227350, Compound 133 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(F)c1)-c1nnc[nH]1
Show InChI InChI=1S/C24H14F3N7/c1-12-32-22-15(24-30-11-31-33-24)8-14(13-4-6-28-20(27)10-13)9-19(22)34(12)18-5-7-29-23-17(26)3-2-16(25)21(18)23/h2-11H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368706
PNG
(US10227350, Compound 121 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(Cl)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14Cl2N8/c1-13-33-23-17(25-31-12-32-34-25)9-15(14-4-6-29-16(8-14)11-28)10-21(23)35(13)20-5-7-30-24-19(27)3-2-18(26)22(20)24/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368680
PNG
(US10227350, Compound 109 | US10227350, Compound 11...)
Show SMILES CCc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C25H17F3N8/c1-2-19-34-22-14(25-32-11-33-35-25)9-12(13-5-7-31-24(29)21(13)28)10-18(22)36(19)17-6-8-30-23-16(27)4-3-15(26)20(17)23/h3-11H,2H2,1H3,(H2,29,31)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368662
PNG
(US10227350, Compound 80)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H16ClFN8/c1-12-32-22-16(24-30-11-31-33-24)9-13(14-5-7-29-23(27)20(14)26)10-19(22)34(12)18-6-8-28-21-15(18)3-2-4-17(21)25/h2-11H,1H3,(H2,27,29)(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368625
PNG
(US10227350, Compound 113 | US10227350, Compound 11...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14F2N8/c1-13-33-23-17(25-31-12-32-34-25)9-15(14-4-6-29-16(8-14)11-28)10-21(23)35(13)20-5-7-30-24-19(27)3-2-18(26)22(20)24/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368665
PNG
(US10227350, Compound 83)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15ClF2N8/c1-11-33-21-14(24-31-10-32-34-24)8-12(13-4-6-30-23(28)20(13)27)9-18(21)35(11)17-5-7-29-22-15(25)2-3-16(26)19(17)22/h2-10H,1H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368657
PNG
(US10227350, Compound 105 | US10227350, Compound 10...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15F3N8/c1-11-33-21-14(24-31-10-32-34-24)8-12(13-4-6-30-23(28)20(13)27)9-18(21)35(11)17-5-7-29-22-16(26)3-2-15(25)19(17)22/h2-10H,1H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
PDB
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368700
PNG
(US10227350, Compound 115 | US10227350, Compound 11...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cc(F)cc(F)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14F2N8/c1-13-33-24-18(25-31-12-32-34-25)7-15(14-2-4-29-17(6-14)11-28)8-22(24)35(13)21-3-5-30-20-10-16(26)9-19(27)23(20)21/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368632
PNG
(US10227350, Compound 51)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C24H16ClFN8/c1-12-32-22-15(24-30-11-31-33-24)8-14(13-4-6-28-20(27)10-13)9-19(22)34(12)18-5-7-29-23-16(25)2-3-17(26)21(18)23/h2-11H,1H3,(H2,27,28)(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368714
PNG
(US10227350, Compound 129 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H15ClN8/c1-14-32-24-19(25-30-13-31-33-25)10-16(15-5-7-28-17(9-15)12-27)11-22(24)34(14)21-6-8-29-23-18(21)3-2-4-20(23)26/h2-11,13H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368590
PNG
(US10227350, Compound 11)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)-c1ccncc1)C(N)=O
Show InChI InChI=1S/C23H15ClFN5O/c1-12-29-21-15(23(26)31)10-14(13-4-7-27-8-5-13)11-19(21)30(12)18-6-9-28-22-16(24)2-3-17(25)20(18)22/h2-11H,1H3,(H2,26,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368668
PNG
(US10227350, Compound 85)
Show SMILES Nc1nccc(-c2cc(-c3nnc[nH]3)c3nc(C4CC4)n(-c4ccnc5c(Cl)ccc(F)c45)c3c2)c1F
Show InChI InChI=1S/C26H17ClF2N8/c27-16-3-4-17(28)20-18(6-8-31-23(16)20)37-19-10-13(14-5-7-32-24(30)21(14)29)9-15(25-33-11-34-36-25)22(19)35-26(37)12-1-2-12/h3-12H,1-2H2,(H2,30,32)(H,33,34,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368672
PNG
(US10227350, Compound 89)
Show SMILES Cc1nc2c(cc(cc2n1-c1c(C)cnc2c(Cl)cccc12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C25H18ClFN8/c1-12-10-30-21-16(4-3-5-18(21)26)23(12)35-13(2)33-22-17(25-31-11-32-34-25)8-14(9-19(22)35)15-6-7-29-24(28)20(15)27/h3-11H,1-2H3,(H2,28,29)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368657
PNG
(US10227350, Compound 105 | US10227350, Compound 10...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15F3N8/c1-11-33-21-14(24-31-10-32-34-24)8-12(13-4-6-30-23(28)20(13)27)9-18(21)35(11)17-5-7-29-22-16(26)3-2-15(25)19(17)22/h2-10H,1H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
PDB
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368618
PNG
(US10227350, Compound 37)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)-c1ccncc1)-c1nnc[nH]1
Show InChI InChI=1S/C24H15ClFN7/c1-13-31-22-16(24-29-12-30-32-24)10-15(14-4-7-27-8-5-14)11-20(22)33(13)19-6-9-28-23-17(25)2-3-18(26)21(19)23/h2-12H,1H3,(H,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368716
PNG
(US10227350, Compound 131 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cccc(F)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H15FN8/c1-14-32-24-18(25-30-13-31-33-25)10-16(15-5-7-28-17(9-15)12-27)11-22(24)34(14)21-6-8-29-20-4-2-3-19(26)23(20)21/h2-11,13H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368720
PNG
(US10227350, Compound 135 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14ClFN8/c1-13-33-23-17(25-31-12-32-34-25)9-15(14-4-6-29-16(8-14)11-28)10-21(23)35(13)20-5-7-30-24-18(26)2-3-19(27)22(20)24/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368704
PNG
(US10227350, Compound 119 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(Cl)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15Cl2FN8/c1-11-33-21-14(24-31-10-32-34-24)8-12(13-4-6-30-23(28)20(13)27)9-18(21)35(11)17-5-7-29-22-16(26)3-2-15(25)19(17)22/h2-10H,1H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368702
PNG
(US10227350, Compound 117 | US10227350, Compound 11...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cc(F)cc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15F3N8/c1-11-33-22-15(24-31-10-32-34-24)6-12(14-2-4-30-23(28)21(14)27)7-19(22)35(11)18-3-5-29-17-9-13(25)8-16(26)20(17)18/h2-10H,1H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368714
PNG
(US10227350, Compound 129 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H15ClN8/c1-14-32-24-19(25-30-13-31-33-25)10-16(15-5-7-28-17(9-15)12-27)11-22(24)34(14)21-6-8-29-23-18(21)3-2-4-20(23)26/h2-11,13H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368625
PNG
(US10227350, Compound 113 | US10227350, Compound 11...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14F2N8/c1-13-33-23-17(25-31-12-32-34-25)9-15(14-4-6-29-16(8-14)11-28)10-21(23)35(13)20-5-7-30-24-19(27)3-2-18(26)22(20)24/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368666
PNG
(US10227350, Compound 84)
Show SMILES CCCc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C26H19ClF2N8/c1-2-3-20-35-23-15(26-33-12-34-36-26)10-13(14-6-8-32-25(30)22(14)29)11-19(23)37(20)18-7-9-31-24-16(27)4-5-17(28)21(18)24/h4-12H,2-3H2,1H3,(H2,30,32)(H,33,34,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368621
PNG
(US10227350, Compound 40)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccnc(C)c1)-c1nnc[nH]1
Show InChI InChI=1S/C25H18ClN7/c1-14-10-16(6-8-27-14)17-11-19(25-29-13-30-32-25)24-22(12-17)33(15(2)31-24)21-7-9-28-23-18(21)4-3-5-20(23)26/h3-13H,1-2H3,(H,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368660
PNG
(US10227350, Compound 78)
Show SMILES CCCc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C26H19F3N8/c1-2-3-20-35-23-15(26-33-12-34-36-26)10-13(14-6-8-32-25(30)22(14)29)11-19(23)37(20)18-7-9-31-24-17(28)5-4-16(27)21(18)24/h4-12H,2-3H2,1H3,(H2,30,32)(H,33,34,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368606
PNG
(US10227350, Compound 27)
Show SMILES Clc1cccc2c(ccnc12)-n1cnc2c(cc(cc12)-c1ccncc1)-c1ncn[nH]1
Show InChI InChI=1S/C23H14ClN7/c24-18-3-1-2-16-19(6-9-26-21(16)18)31-13-28-22-17(23-27-12-29-30-23)10-15(11-20(22)31)14-4-7-25-8-5-14/h1-13H,(H,27,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368680
PNG
(US10227350, Compound 109 | US10227350, Compound 11...)
Show SMILES CCc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C25H17F3N8/c1-2-19-34-22-14(25-32-11-33-35-25)9-12(13-5-7-31-24(29)21(13)28)10-18(22)36(19)17-6-8-30-23-16(27)4-3-15(26)20(17)23/h3-11H,2H2,1H3,(H2,29,31)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368683
PNG
(US10227350, Compound 111 | US10227350, Compound 11...)
Show SMILES Cc1nnc([nH]1)-c1cc(cc2n(c(C)nc12)-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1F
Show InChI InChI=1S/C25H17ClF2N8/c1-11-32-25(35-34-11)15-9-13(14-5-7-31-24(29)21(14)28)10-19-22(15)33-12(2)36(19)18-6-8-30-23-16(26)3-4-17(27)20(18)23/h3-10H,1-2H3,(H2,29,31)(H,32,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368718
PNG
(US10227350, Compound 133 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(F)c1)-c1nnc[nH]1
Show InChI InChI=1S/C24H14F3N7/c1-12-32-22-15(24-30-11-31-33-24)8-14(13-4-6-28-20(27)10-13)9-19(22)34(12)18-5-7-29-23-17(26)3-2-16(25)21(18)23/h2-11H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368678
PNG
(US10227350, Compound 93)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cccc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H16F2N8/c1-12-32-22-15(24-30-11-31-33-24)9-13(14-5-7-29-23(27)21(14)26)10-19(22)34(12)18-6-8-28-17-4-2-3-16(25)20(17)18/h2-11H,1H3,(H2,27,29)(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368620
PNG
(US10227350, Compound 137 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccncc1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15ClFN7/c1-13-31-23-17(24-29-12-30-32-24)9-14(15-5-7-27-11-19(15)26)10-21(23)33(13)20-6-8-28-22-16(20)3-2-4-18(22)25/h2-12H,1H3,(H,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368724
PNG
(US10227350, Compound 139 | US10227350, Compound 14...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccncc1)-c1nnc[nH]1
Show InChI InChI=1S/C24H15F2N7/c1-13-31-22-16(24-29-12-30-32-24)10-15(14-4-7-27-8-5-14)11-20(22)33(13)19-6-9-28-23-18(26)3-2-17(25)21(19)23/h2-12H,1H3,(H,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368608
PNG
(US10227350, Compound 29)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(Cl)c12)-c1ccncc1)-c1nnc[nH]1
Show InChI InChI=1S/C24H15Cl2N7/c1-13-31-22-16(24-29-12-30-32-24)10-15(14-4-7-27-8-5-14)11-20(22)33(13)19-6-9-28-23-18(26)3-2-17(25)21(19)23/h2-12H,1H3,(H,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368704
PNG
(US10227350, Compound 119 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(Cl)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15Cl2FN8/c1-11-33-21-14(24-31-10-32-34-24)8-12(13-4-6-30-23(28)20(13)27)9-18(21)35(11)17-5-7-29-22-16(26)3-2-15(25)19(17)22/h2-10H,1H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368611
PNG
(US10227350, Compound 32)
Show SMILES Cc1nc2c(cc(cc2n1-c1cc(C)nc2c(Cl)cccc12)-c1ccncc1)-c1nnc[nH]1
Show InChI InChI=1S/C25H18ClN7/c1-14-10-21(18-4-3-5-20(26)23(18)30-14)33-15(2)31-24-19(25-28-13-29-32-25)11-17(12-22(24)33)16-6-8-27-9-7-16/h3-13H,1-2H3,(H,28,29,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368604
PNG
(US10227350, Compound 25)
Show SMILES NC(=O)c1cc(cc2n(c(nc12)C1CC1)-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1F
Show InChI InChI=1S/C25H17ClF2N6O/c26-15-3-4-16(27)19-17(6-8-31-22(15)19)34-18-10-12(13-5-7-32-23(29)20(13)28)9-14(24(30)35)21(18)33-25(34)11-1-2-11/h3-11H,1-2H2,(H2,29,32)(H2,30,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368700
PNG
(US10227350, Compound 115 | US10227350, Compound 11...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cc(F)cc(F)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14F2N8/c1-13-33-24-18(25-31-12-32-34-25)7-15(14-2-4-29-17(6-14)11-28)8-22(24)35(13)21-3-5-30-20-10-16(26)9-19(27)23(20)21/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368683
PNG
(US10227350, Compound 111 | US10227350, Compound 11...)
Show SMILES Cc1nnc([nH]1)-c1cc(cc2n(c(C)nc12)-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1F
Show InChI InChI=1S/C25H17ClF2N8/c1-11-32-25(35-34-11)15-9-13(14-5-7-31-24(29)21(14)28)10-19-22(15)33-12(2)36(19)18-6-8-30-23-16(26)3-4-17(27)20(18)23/h3-10H,1-2H3,(H2,29,31)(H,32,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368607
PNG
(US10227350, Compound 28)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccncc1)-c1nnc[nH]1
Show InChI InChI=1S/C24H15F2N7/c1-13-31-22-16(24-29-12-30-32-24)10-15(14-4-7-27-8-5-14)11-20(22)33(13)19-6-9-28-23-18(26)3-2-17(25)21(19)23/h2-12H,1H3,(H,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368720
PNG
(US10227350, Compound 135 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14ClFN8/c1-13-33-23-17(25-31-12-32-34-25)9-15(14-4-6-29-16(8-14)11-28)10-21(23)35(13)20-5-7-30-24-18(26)2-3-19(27)22(20)24/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368702
PNG
(US10227350, Compound 117 | US10227350, Compound 11...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cc(F)cc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15F3N8/c1-11-33-22-15(24-31-10-32-34-24)6-12(14-2-4-30-23(28)21(14)27)7-19(22)35(11)18-3-5-29-17-9-13(25)8-16(26)20(17)18/h2-10H,1H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368669
PNG
(US10227350, Compound 86)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)cccc12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H16F2N8/c1-12-32-22-16(24-30-11-31-33-24)9-13(14-5-7-29-23(27)20(14)26)10-19(22)34(12)18-6-8-28-21-15(18)3-2-4-17(21)25/h2-11H,1H3,(H2,27,29)(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368619
PNG
(US10227350, Compound 38)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccncc1)-c1nnc[nH]1
Show InChI InChI=1S/C24H16ClN7/c1-14-30-23-18(24-28-13-29-31-24)11-16(15-5-8-26-9-6-15)12-21(23)32(14)20-7-10-27-22-17(20)3-2-4-19(22)25/h2-13H,1H3,(H,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368644
PNG
(US10227350, Compound 63)
Show SMILES CCCc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C26H20ClFN8/c1-2-3-22-34-24-16(26-32-13-33-35-26)10-15(14-6-8-30-21(29)12-14)11-20(24)36(22)19-7-9-31-25-17(27)4-5-18(28)23(19)25/h4-13H,2-3H2,1H3,(H2,29,30)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368743
PNG
(US10227350, Compound 158)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(Cl)c1)-c1nnc[nH]1
Show InChI InChI=1S/C24H14ClF2N7/c1-12-32-22-15(24-30-11-31-33-24)8-14(13-4-6-28-20(25)10-13)9-19(22)34(12)18-5-7-29-23-17(27)3-2-16(26)21(18)23/h2-11H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368681
PNG
(US10227350, Compound 96)
Show SMILES Nc1nccc(-c2cc(-c3nnc[nH]3)c3nc(CC4CC4)n(-c4ccnc5c(F)ccc(F)c45)c3c2)c1F
Show InChI InChI=1S/C27H19F3N8/c28-17-3-4-18(29)25-22(17)19(6-8-32-25)38-20-11-14(15-5-7-33-26(31)23(15)30)10-16(27-34-12-35-37-27)24(20)36-21(38)9-13-1-2-13/h3-8,10-13H,1-2,9H2,(H2,31,33)(H,34,35,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368648
PNG
(US10227350, Compound 67)
Show SMILES CC(C)c1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C26H20ClFN8/c1-13(2)26-34-23-16(25-32-12-33-35-25)9-15(14-5-7-30-21(29)11-14)10-20(23)36(26)19-6-8-31-24-17(27)3-4-18(28)22(19)24/h3-13H,1-2H3,(H2,29,30)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368654
PNG
(US10227350, Compound 73)
Show SMILES Nc1cc(ccn1)-c1cc(-c2nnc[nH]2)c2nc(CC3CC3)n(-c3ccnc4c(Cl)cccc34)c2c1
Show InChI InChI=1S/C27H21ClN8/c28-20-3-1-2-18-21(7-9-31-25(18)20)36-22-12-17(16-6-8-30-23(29)13-16)11-19(27-32-14-33-35-27)26(22)34-24(36)10-15-4-5-15/h1-3,6-9,11-15H,4-5,10H2,(H2,29,30)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368626
PNG
(US10227350, Compound 141 | US10227350, Compound 14...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(C)c1)-c1nnc[nH]1
Show InChI InChI=1S/C25H17F2N7/c1-13-9-15(5-7-28-13)16-10-17(25-30-12-31-33-25)23-21(11-16)34(14(2)32-23)20-6-8-29-24-19(27)4-3-18(26)22(20)24/h3-12H,1-2H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368679
PNG
(US10227350, Compound 94)
Show SMILES CCc1nc2c(cc(cc2n1-c1ccnc2cccc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C25H18F2N8/c1-2-20-33-23-15(25-31-12-32-34-25)10-13(14-6-8-30-24(28)22(14)27)11-19(23)35(20)18-7-9-29-17-5-3-4-16(26)21(17)18/h3-12H,2H2,1H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368708
PNG
(US10227350, Compound 123 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(Cl)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14ClFN8/c1-13-33-23-17(25-31-12-32-34-25)9-15(14-4-6-29-16(8-14)11-28)10-21(23)35(13)20-5-7-30-24-19(27)3-2-18(26)22(20)24/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368609
PNG
(US10227350, Compound 30)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cccc(F)c12)-c1ccncc1)-c1nnc[nH]1
Show InChI InChI=1S/C24H16FN7/c1-14-30-23-17(24-28-13-29-31-24)11-16(15-5-8-26-9-6-15)12-21(23)32(14)20-7-10-27-19-4-2-3-18(25)22(19)20/h2-13H,1H3,(H,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368643
PNG
(US10227350, Compound 62)
Show SMILES Nc1cc(ccn1)-c1cc(-c2nnc[nH]2)c2nc(C3CC3)n(-c3ccnc4c(Cl)ccc(F)c34)c2c1
Show InChI InChI=1S/C26H18ClFN8/c27-17-3-4-18(28)22-19(6-8-31-24(17)22)36-20-10-15(14-5-7-30-21(29)11-14)9-16(25-32-12-33-35-25)23(20)34-26(36)13-1-2-13/h3-13H,1-2H2,(H2,29,30)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368661
PNG
(US10227350, Compound 79)
Show SMILES Nc1nccc(-c2cc(-c3nnc[nH]3)c3nc(C4CC4)n(-c4ccnc5c(Cl)cccc45)c3c2)c1F
Show InChI InChI=1S/C26H18ClFN8/c27-18-3-1-2-16-19(7-9-30-22(16)18)36-20-11-14(15-6-8-31-24(29)21(15)28)10-17(25-32-12-33-35-25)23(20)34-26(36)13-4-5-13/h1-3,6-13H,4-5H2,(H2,29,31)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368739
PNG
(US10227350, Compound 154)
Show SMILES COc1nccc(n1)-c1cc(-c2nnc[nH]2)c2nc(C)n(-c3ccnc4c(F)ccc(F)c34)c2c1
Show InChI InChI=1S/C24H16F2N8O/c1-12-31-21-14(23-29-11-30-33-23)9-13(17-5-7-28-24(32-17)35-2)10-19(21)34(12)18-6-8-27-22-16(26)4-3-15(25)20(18)22/h3-11H,1-2H3,(H,29,30,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368712
PNG
(US10227350, Compound 127 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)cccc12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H15FN8/c1-14-32-24-19(25-30-13-31-33-25)10-16(15-5-7-28-17(9-15)12-27)11-22(24)34(14)21-6-8-29-23-18(21)3-2-4-20(23)26/h2-11,13H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368688
PNG
(US10227350, Compound 103 | US10227350, Compound 10...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C24H16F2N8/c1-12-32-22-15(24-30-11-31-33-24)8-14(13-4-6-28-20(27)10-13)9-19(22)34(12)18-5-7-29-23-17(26)3-2-16(25)21(18)23/h2-11H,1H3,(H2,27,28)(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368637
PNG
(US10227350, Compound 56)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccnc(N)n1)-c1nnc[nH]1
Show InChI InChI=1S/C23H16ClN9/c1-12-30-21-15(22-28-11-29-32-22)9-13(17-5-7-27-23(25)31-17)10-19(21)33(12)18-6-8-26-20-14(18)3-2-4-16(20)24/h2-11H,1H3,(H2,25,27,31)(H,28,29,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368752
PNG
(US10227350, Compound 167)
Show SMILES N#Cc1cc(ccn1)-c1cc(-c2nnc[nH]2)c2ncn(-c3cc(nc4ccccc34)N3CCNCC3)c2c1
Show InChI InChI=1S/C28H22N10/c29-15-20-11-18(5-6-31-20)19-12-22(28-32-16-34-36-28)27-25(13-19)38(17-33-27)24-14-26(37-9-7-30-8-10-37)35-23-4-2-1-3-21(23)24/h1-6,11-14,16-17,30H,7-10H2,(H,32,34,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368620
PNG
(US10227350, Compound 137 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccncc1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15ClFN7/c1-13-31-23-17(24-29-12-30-32-24)9-14(15-5-7-27-11-19(15)26)10-21(23)33(13)20-6-8-28-22-16(20)3-2-4-18(22)25/h2-12H,1H3,(H,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368629
PNG
(US10227350, Compound 48)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C24H16F2N8/c1-12-32-22-15(24-30-11-31-33-24)8-14(13-4-6-28-20(27)10-13)9-19(22)34(12)18-5-7-29-23-17(26)3-2-16(25)21(18)23/h2-11H,1H3,(H2,27,28)(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368653
PNG
(US10227350, Compound 72)
Show SMILES CCCc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C26H20F2N8/c1-2-3-22-34-24-16(26-32-13-33-35-26)10-15(14-6-8-30-21(29)12-14)11-20(24)36(22)19-7-9-31-25-18(28)5-4-17(27)23(19)25/h4-13H,2-3H2,1H3,(H2,29,30)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368747
PNG
(US10227350, Compound 162)
Show SMILES Nc1nccc(-c2cc(-c3nnc[nH]3)c3ncn(-c4cc(nc5ccccc45)N4CCNCC4)c3c2)c1F
Show InChI InChI=1S/C27H23FN10/c28-24-17(5-6-31-26(24)29)16-11-19(27-32-14-34-36-27)25-22(12-16)38(15-33-25)21-13-23(37-9-7-30-8-10-37)35-20-4-2-1-3-18(20)21/h1-6,11-15,30H,7-10H2,(H2,29,31)(H,32,34,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368639
PNG
(US10227350, Compound 58)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccnc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C24H17ClN8/c1-13-31-23-17(24-29-12-30-32-24)9-15(14-5-7-27-21(26)11-14)10-20(23)33(13)19-6-8-28-22-16(19)3-2-4-18(22)25/h2-12H,1H3,(H2,26,27)(H,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368737
PNG
(US10227350, Compound 152)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(n1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C24H13F2N9/c1-12-32-22-14(24-30-11-31-34-24)8-13(17-4-6-28-20(10-27)33-17)9-19(22)35(12)18-5-7-29-23-16(26)3-2-15(25)21(18)23/h2-9,11H,1H3,(H,30,31,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368749
PNG
(US10227350, Compound 164)
Show SMILES Fc1nccc(-c2cc(-c3nnc[nH]3)c3ncn(-c4cc(nc5ccccc45)N4CCNCC4)c3c2)c1F
Show InChI InChI=1S/C27H21F2N9/c28-24-17(5-6-31-26(24)29)16-11-19(27-32-14-34-36-27)25-22(12-16)38(15-33-25)21-13-23(37-9-7-30-8-10-37)35-20-4-2-1-3-18(20)21/h1-6,11-15,30H,7-10H2,(H,32,34,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368623
PNG
(US10227350, Compound 42)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(F)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H13F4N7/c1-11-33-21-14(24-31-10-32-34-24)8-12(13-4-6-30-23(28)20(13)27)9-18(21)35(11)17-5-7-29-22-16(26)3-2-15(25)19(17)22/h2-10H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368687
PNG
(US10227350, Compound 102)
Show SMILES Nc1nccc(-c2cc(-c3nnc[nH]3)c3ncn(-c4ccnc5c(F)ccc(F)c45)c3c2)c1F
Show InChI InChI=1S/C23H13F3N8/c24-14-1-2-15(25)21-18(14)16(4-6-28-21)34-10-31-20-13(23-30-9-32-33-23)7-11(8-17(20)34)12-3-5-29-22(27)19(12)26/h1-10H,(H2,27,29)(H,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368626
PNG
(US10227350, Compound 141 | US10227350, Compound 14...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(C)c1)-c1nnc[nH]1
Show InChI InChI=1S/C25H17F2N7/c1-13-9-15(5-7-28-13)16-10-17(25-30-12-31-33-25)23-21(11-16)34(14(2)32-23)20-6-8-29-24-19(27)4-3-18(26)22(20)24/h3-12H,1-2H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368598
PNG
(US10227350, Compound 19)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccnc(N)n1)C(N)=O
Show InChI InChI=1S/C22H16ClN7O/c1-11-28-20-14(21(24)31)9-12(16-5-7-27-22(25)29-16)10-18(20)30(11)17-6-8-26-19-13(17)3-2-4-15(19)23/h2-10H,1H3,(H2,24,31)(H2,25,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368670
PNG
(US10227350, Compound 87)
Show SMILES CCCc1nc2c(cc(cc2n1-c1ccnc2c(F)cccc12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C26H20F2N8/c1-2-4-21-34-24-17(26-32-13-33-35-26)11-14(15-7-9-31-25(29)22(15)28)12-20(24)36(21)19-8-10-30-23-16(19)5-3-6-18(23)27/h3,5-13H,2,4H2,1H3,(H2,29,31)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368741
PNG
(US10227350, Compound 156)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(C)n1)-c1nnc[nH]1
Show InChI InChI=1S/C24H16F2N8/c1-12-27-7-5-18(31-12)14-9-15(24-29-11-30-33-24)22-20(10-14)34(13(2)32-22)19-6-8-28-23-17(26)4-3-16(25)21(19)23/h3-11H,1-2H3,(H,29,30,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368605
PNG
(US10227350, Compound 26)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1F)C(N)=O
Show InChI InChI=1S/C23H15F3N6O/c1-10-31-20-13(23(28)33)8-11(12-4-6-30-22(27)19(12)26)9-17(20)32(10)16-5-7-29-21-15(25)3-2-14(24)18(16)21/h2-9H,1H3,(H2,27,30)(H2,28,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368581
PNG
(US10227350, Compound 2)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccnc(N)n1)C(O)=O
Show InChI InChI=1S/C22H15ClN6O2/c1-11-27-20-14(21(30)31)9-12(16-5-7-26-22(24)28-16)10-18(20)29(11)17-6-8-25-19-13(17)3-2-4-15(19)23/h2-10H,1H3,(H,30,31)(H2,24,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368651
PNG
(US10227350, Compound 70)
Show SMILES CCc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C25H18F2N8/c1-2-21-33-23-15(25-31-12-32-34-25)9-14(13-5-7-29-20(28)11-13)10-19(23)35(21)18-6-8-30-24-17(27)4-3-16(26)22(18)24/h3-12H,2H2,1H3,(H2,28,29)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368735
PNG
(US10227350, Compound 150)
Show SMILES Cc1nnc([nH]1)-c1cc(cc2n(c(C)nc12)-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(c1)C#N
Show InChI InChI=1S/C26H16ClFN8/c1-13-32-26(35-34-13)18-10-16(15-5-7-30-17(9-15)12-29)11-22-24(18)33-14(2)36(22)21-6-8-31-25-19(27)3-4-20(28)23(21)25/h3-11H,1-2H3,(H,32,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368652
PNG
(US10227350, Compound 71)
Show SMILES Nc1cc(ccn1)-c1cc(-c2nnc[nH]2)c2nc(CC3CC3)n(-c3ccnc4c(F)ccc(F)c34)c2c1
Show InChI InChI=1S/C27H20F2N8/c28-18-3-4-19(29)26-24(18)20(6-8-32-26)37-21-11-16(15-5-7-31-22(30)12-15)10-17(27-33-13-34-36-27)25(21)35-23(37)9-14-1-2-14/h3-8,10-14H,1-2,9H2,(H2,30,31)(H,33,34,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368592
PNG
(US10227350, Compound 13)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccncc1)C(N)=O
Show InChI InChI=1S/C23H16ClN5O/c1-13-28-22-17(23(25)30)11-15(14-5-8-26-9-6-14)12-20(22)29(13)19-7-10-27-21-16(19)3-2-4-18(21)24/h2-12H,1H3,(H2,25,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368663
PNG
(US10227350, Compound 81)
Show SMILES Nc1nccc(-c2cc(-c3nnc[nH]3)c3nc(C4CC4)n(-c4ccnc5c(F)ccc(F)c45)c3c2)c1F
Show InChI InChI=1S/C26H17F3N8/c27-16-3-4-17(28)23-20(16)18(6-8-31-23)37-19-10-13(14-5-7-32-24(30)21(14)29)9-15(25-33-11-34-36-25)22(19)35-26(37)12-1-2-12/h3-12H,1-2H2,(H2,30,32)(H,33,34,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368586
PNG
(US10227350, Compound 7)
Show SMILES Cc1nc2c(cc(cc2n1-c1cc(C)nc2c(Cl)cccc12)-c1ccncc1)C(N)=O
Show InChI InChI=1S/C24H18ClN5O/c1-13-10-20(17-4-3-5-19(25)22(17)28-13)30-14(2)29-23-18(24(26)31)11-16(12-21(23)30)15-6-8-27-9-7-15/h3-12H,1-2H3,(H2,26,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368646
PNG
(US10227350, Compound 65)
Show SMILES CCCc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1)-c1nnc(C)[nH]1
Show InChI InChI=1S/C27H22ClFN8/c1-3-4-23-34-25-17(27-33-14(2)35-36-27)11-16(15-7-9-31-22(30)13-15)12-21(25)37(23)20-8-10-32-26-18(28)5-6-19(29)24(20)26/h5-13H,3-4H2,1-2H3,(H2,30,31)(H,33,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368712
PNG
(US10227350, Compound 127 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)cccc12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H15FN8/c1-14-32-24-19(25-30-13-31-33-25)10-16(15-5-7-28-17(9-15)12-27)11-22(24)34(14)21-6-8-29-23-18(21)3-2-4-20(23)26/h2-11,13H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368631
PNG
(US10227350, Compound 50)
Show SMILES Cc1nnc([nH]1)-c1cc(cc2n(c(C)nc12)-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1
Show InChI InChI=1S/C25H18ClFN8/c1-12-31-25(34-33-12)16-9-15(14-5-7-29-21(28)11-14)10-20-23(16)32-13(2)35(20)19-6-8-30-24-17(26)3-4-18(27)22(19)24/h3-11H,1-2H3,(H2,28,29)(H,31,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 17n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368708
PNG
(US10227350, Compound 123 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(Cl)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14ClFN8/c1-13-33-23-17(25-31-12-32-34-25)9-15(14-4-6-29-16(8-14)11-28)10-21(23)35(13)20-5-7-30-24-19(27)3-2-18(26)22(20)24/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368674
PNG
(US10227350, Compound 91)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1Cl)-c1nnc[nH]1
Show InChI InChI=1S/C24H15ClF2N8/c1-11-33-21-14(24-31-10-32-34-24)8-12(13-4-6-30-23(28)20(13)25)9-18(21)35(11)17-5-7-29-22-16(27)3-2-15(26)19(17)22/h2-10H,1H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368636
PNG
(US10227350, Compound 55)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cccc(F)c12)-c1ccnc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C24H17FN8/c1-13-31-23-16(24-29-12-30-32-24)9-15(14-5-7-28-21(26)11-14)10-20(23)33(13)19-6-8-27-18-4-2-3-17(25)22(18)19/h2-12H,1H3,(H2,26,28)(H,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368583
PNG
(US10227350, Compound 4)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1F)C(O)=O
Show InChI InChI=1S/C23H14F3N5O2/c1-10-30-20-13(23(32)33)8-11(12-4-6-29-22(27)19(12)26)9-17(20)31(10)16-5-7-28-21-15(25)3-2-14(24)18(16)21/h2-9H,1H3,(H2,27,29)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368616
PNG
(US10227350, Compound 35)
Show SMILES Cc1nnc([nH]1)-c1cc(cc2n(c(C)nc12)-c1ccnc2c(Cl)cccc12)-c1ccncc1
Show InChI InChI=1S/C25H18ClN7/c1-14-29-25(32-31-14)19-12-17(16-6-9-27-10-7-16)13-22-24(19)30-15(2)33(22)21-8-11-28-23-18(21)4-3-5-20(23)26/h3-13H,1-2H3,(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 22n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368603
PNG
(US10227350, Compound 24)
Show SMILES CCCc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1F)C(N)=O
Show InChI InChI=1S/C25H19F3N6O/c1-2-3-19-33-22-14(25(30)35)10-12(13-6-8-32-24(29)21(13)28)11-18(22)34(19)17-7-9-31-23-16(27)5-4-15(26)20(17)23/h4-11H,2-3H2,1H3,(H2,29,32)(H2,30,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 22n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368597
PNG
(US10227350, Compound 18)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1)C(N)=O
Show InChI InChI=1S/C23H16ClFN6O/c1-11-30-21-14(23(27)32)8-13(12-4-6-28-19(26)10-12)9-18(21)31(11)17-5-7-29-22-15(24)2-3-16(25)20(17)22/h2-10H,1H3,(H2,26,28)(H2,27,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 23n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368613
PNG
(US10227350, Compound 34)
Show SMILES Cc1nc2c(cc(cc2n1-c1cc(C)nc2ccccc12)-c1ccncc1)-c1nnc[nH]1
Show InChI InChI=1S/C25H19N7/c1-15-11-22(19-5-3-4-6-21(19)29-15)32-16(2)30-24-20(25-27-14-28-31-25)12-18(13-23(24)32)17-7-9-26-10-8-17/h3-14H,1-2H3,(H,27,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 26n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368622
PNG
(US10227350, Compound 41)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1cc(F)ncc1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H13F4N7/c1-11-33-22-14(24-31-10-32-34-24)6-12(13-8-20(28)30-9-17(13)27)7-19(22)35(11)18-4-5-29-23-16(26)3-2-15(25)21(18)23/h2-10H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 27n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368706
PNG
(US10227350, Compound 121 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(Cl)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14Cl2N8/c1-13-33-23-17(25-31-12-32-34-25)9-15(14-4-6-29-16(8-14)11-28)10-21(23)35(13)20-5-7-30-24-19(27)3-2-18(26)22(20)24/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 28n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368655
PNG
(US10227350, Compound 74)
Show SMILES Nc1cc(ccn1)-c1cc(-c2nnc[nH]2)c2nc(C3CC3)n(-c3ccnc4c(Cl)cccc34)c2c1
Show InChI InChI=1S/C26H19ClN8/c27-19-3-1-2-17-20(7-9-30-23(17)19)35-21-11-16(15-6-8-29-22(28)12-15)10-18(25-31-13-32-34-25)24(21)33-26(35)14-4-5-14/h1-3,6-14H,4-5H2,(H2,28,29)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 29n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368675
PNG
(US10227350, Compound 107 | US10227350, Compound 10...)
Show SMILES Cc1nc2c(cc(cc2n1-c1c(Cl)cnc2c(F)cccc12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15ClF2N8/c1-11-33-21-15(24-31-10-32-34-24)7-12(13-5-6-29-23(28)19(13)27)8-18(21)35(11)22-14-3-2-4-17(26)20(14)30-9-16(22)25/h2-10H,1H3,(H2,28,29)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 29n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368684
PNG
(US10227350, Compound 99)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(Cl)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15ClF2N8/c1-11-33-21-14(24-31-10-32-34-24)8-12(13-4-6-30-23(28)20(13)27)9-18(21)35(11)17-5-7-29-22-16(26)3-2-15(25)19(17)22/h2-10H,1H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 29n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368700
PNG
(US10227350, Compound 115 | US10227350, Compound 11...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cc(F)cc(F)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14F2N8/c1-13-33-24-18(25-31-12-32-34-25)7-15(14-2-4-29-17(6-14)11-28)8-22(24)35(13)21-3-5-30-20-10-16(26)9-19(27)23(20)21/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368624
PNG
(US10227350, Compound 43)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(c1)C(F)F)-c1nnc[nH]1
Show InChI InChI=1S/C25H15F4N7/c1-12-34-22-15(25-32-11-33-35-25)8-14(13-4-6-30-18(9-13)24(28)29)10-20(22)36(12)19-5-7-31-23-17(27)3-2-16(26)21(19)23/h2-11,24H,1H3,(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368682
PNG
(US10227350, Compound 97)
Show SMILES Cc1nnc([nH]1)-c1cc(cc2n(c(C)nc12)-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1F
Show InChI InChI=1S/C25H17F3N8/c1-11-32-25(35-34-11)15-9-13(14-5-7-31-24(29)21(14)28)10-19-22(15)33-12(2)36(19)18-6-8-30-23-17(27)4-3-16(26)20(18)23/h3-10H,1-2H3,(H2,29,31)(H,32,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 31n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368551
PNG
(US10227350, Compound 1)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccncc1)C(O)=O
Show InChI InChI=1S/C23H15ClN4O2/c1-13-27-22-17(23(29)30)11-15(14-5-8-25-9-6-14)12-20(22)28(13)19-7-10-26-21-16(19)3-2-4-18(21)24/h2-12H,1H3,(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 34n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368642
PNG
(US10227350, Compound 61)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)cccc12)-c1ccnc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C24H17FN8/c1-13-31-23-17(24-29-12-30-32-24)9-15(14-5-7-27-21(26)11-14)10-20(23)33(13)19-6-8-28-22-16(19)3-2-4-18(22)25/h2-12H,1H3,(H2,26,27)(H,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 35n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368649
PNG
(US10227350, Compound 68)
Show SMILES Nc1cc(ccn1)-c1cc(-c2nnc[nH]2)c2nc(C3COC3)n(-c3ccnc4c(Cl)ccc(F)c34)c2c1
Show InChI InChI=1S/C26H18ClFN8O/c27-17-1-2-18(28)22-19(4-6-31-24(17)22)36-20-8-14(13-3-5-30-21(29)9-13)7-16(25-32-12-33-35-25)23(20)34-26(36)15-10-37-11-15/h1-9,12,15H,10-11H2,(H2,29,30)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 35n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368702
PNG
(US10227350, Compound 117 | US10227350, Compound 11...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cc(F)cc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15F3N8/c1-11-33-22-15(24-31-10-32-34-24)6-12(14-2-4-30-23(28)21(14)27)7-19(22)35(11)18-3-5-29-17-9-13(25)8-16(26)20(17)18/h2-10H,1H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 35n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368585
PNG
(US10227350, Compound 6)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccncc1)C(N)=O
Show InChI InChI=1S/C23H15F2N5O/c1-12-29-21-15(23(26)31)10-14(13-4-7-27-8-5-13)11-19(21)30(12)18-6-9-28-22-17(25)3-2-16(24)20(18)22/h2-11H,1H3,(H2,26,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 36n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368635
PNG
(US10227350, Compound 54)
Show SMILES CCc1nc2c(cc(cc2n1-c1ccnc2cccc(F)c12)-c1ccnc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C25H19FN8/c1-2-22-32-24-16(25-30-13-31-33-25)10-15(14-6-8-29-21(27)12-14)11-20(24)34(22)19-7-9-28-18-5-3-4-17(26)23(18)19/h3-13H,2H2,1H3,(H2,27,29)(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 36n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368628
PNG
(US10227350, Compound 47)
Show SMILES Fc1nccc(-c2cc(-c3nnc[nH]3)c3ncn(-c4ccnc5c(F)ccc(F)c45)c3c2)c1F
Show InChI InChI=1S/C23H11F4N7/c24-14-1-2-15(25)21-18(14)16(4-6-28-21)34-10-31-20-13(23-30-9-32-33-23)7-11(8-17(20)34)12-3-5-29-22(27)19(12)26/h1-10H,(H,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368650
PNG
(US10227350, Compound 69)
Show SMILES Nc1cc(ccn1)-c1cc(-c2nnc[nH]2)c2nc(C3CC3)n(-c3ccnc4c(F)ccc(F)c34)c2c1
Show InChI InChI=1S/C26H18F2N8/c27-17-3-4-18(28)24-22(17)19(6-8-31-24)36-20-10-15(14-5-7-30-21(29)11-14)9-16(25-32-12-33-35-25)23(20)34-26(36)13-1-2-13/h3-13H,1-2H2,(H2,29,30)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 47n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368658
PNG
(US10227350, Compound 76)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1cc(N)ncc1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15F3N8/c1-11-33-22-14(24-31-10-32-34-24)6-12(13-8-20(28)30-9-17(13)27)7-19(22)35(11)18-4-5-29-23-16(26)3-2-15(25)21(18)23/h2-10H,1H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368675
PNG
(US10227350, Compound 107 | US10227350, Compound 10...)
Show SMILES Cc1nc2c(cc(cc2n1-c1c(Cl)cnc2c(F)cccc12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15ClF2N8/c1-11-33-21-15(24-31-10-32-34-24)7-12(13-5-6-29-23(28)19(13)27)8-18(21)35(11)22-14-3-2-4-17(26)20(14)30-9-16(22)25/h2-10H,1H3,(H2,28,29)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 51n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368595
PNG
(US10227350, Compound 16)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(c1)C#N)C(N)=O
Show InChI InChI=1S/C24H14F2N6O/c1-12-31-22-16(24(28)33)9-14(13-4-6-29-15(8-13)11-27)10-20(22)32(12)19-5-7-30-23-18(26)3-2-17(25)21(19)23/h2-10H,1H3,(H2,28,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 51n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368716
PNG
(US10227350, Compound 131 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cccc(F)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H15FN8/c1-14-32-24-18(25-30-13-31-33-25)10-16(15-5-7-28-17(9-15)12-27)11-22(24)34(14)21-6-8-29-20-4-2-3-19(26)23(20)21/h2-11,13H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 54n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368714
PNG
(US10227350, Compound 129 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H15ClN8/c1-14-32-24-19(25-30-13-31-33-25)10-16(15-5-7-28-17(9-15)12-27)11-22(24)34(14)21-6-8-29-23-18(21)3-2-4-20(23)26/h2-11,13H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 57n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368593
PNG
(US10227350, Compound 14)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccncc1F)C(N)=O
Show InChI InChI=1S/C23H15ClFN5O/c1-12-29-22-16(23(26)31)9-13(14-5-7-27-11-18(14)25)10-20(22)30(12)19-6-8-28-21-15(19)3-2-4-17(21)24/h2-11H,1H3,(H2,26,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 62n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368740
PNG
(US10227350, Compound 155)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1cc(C)ncn1)-c1nnc[nH]1
Show InChI InChI=1S/C24H16F2N8/c1-12-7-18(29-10-28-12)14-8-15(24-30-11-31-33-24)22-20(9-14)34(13(2)32-22)19-5-6-27-23-17(26)4-3-16(25)21(19)23/h3-11H,1-2H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 62n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368751
PNG
(US10227350, Compound 166)
Show SMILES N#Cc1cc(ccn1)-c1cc(-c2nnc[nH]2)c2ncn(-c3cc(nc4ccccc34)-c3cn[nH]c3)c2c1
Show InChI InChI=1S/C27H16N10/c28-11-19-7-16(5-6-29-19)17-8-21(27-30-14-34-36-27)26-25(9-17)37(15-31-26)24-10-23(18-12-32-33-13-18)35-22-4-2-1-3-20(22)24/h1-10,12-15H,(H,32,33)(H,30,34,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 70n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368736
PNG
(US10227350, Compound 151)
Show SMILES Cc1nnc([nH]1)-c1cc(cc2n(c(C)nc12)-c1ccnc2c(F)ccc(F)c12)-c1ccnc(c1)C#N
Show InChI InChI=1S/C26H16F2N8/c1-13-32-26(35-34-13)18-10-16(15-5-7-30-17(9-15)12-29)11-22-24(18)33-14(2)36(22)21-6-8-31-25-20(28)4-3-19(27)23(21)25/h3-11H,1-2H3,(H,32,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 80n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368587
PNG
(US10227350, Compound 8)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cccc(F)c12)-c1ccncc1)C(N)=O
Show InChI InChI=1S/C23H16FN5O/c1-13-28-22-16(23(25)30)11-15(14-5-8-26-9-6-14)12-20(22)29(13)19-7-10-27-18-4-2-3-17(24)21(18)19/h2-12H,1H3,(H2,25,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 82n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368584
PNG
(US10227350, Compound 5)
Show SMILES NC(=O)c1cc(cc2n(cnc12)-c1ccnc2c(Cl)cccc12)-c1ccncc1
Show InChI InChI=1S/C22H14ClN5O/c23-17-3-1-2-15-18(6-9-26-20(15)17)28-12-27-21-16(22(24)29)10-14(11-19(21)28)13-4-7-25-8-5-13/h1-12H,(H2,24,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 86n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368704
PNG
(US10227350, Compound 119 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(Cl)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15Cl2FN8/c1-11-33-21-14(24-31-10-32-34-24)8-12(13-4-6-30-23(28)20(13)27)9-18(21)35(11)17-5-7-29-22-16(26)3-2-15(25)19(17)22/h2-10H,1H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 87n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368610
PNG
(US10227350, Compound 31)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cccc(C)c12)-c1ccncc1)-c1nnc[nH]1
Show InChI InChI=1S/C25H19N7/c1-15-4-3-5-20-23(15)21(8-11-27-20)32-16(2)30-24-19(25-28-14-29-31-25)12-18(13-22(24)32)17-6-9-26-10-7-17/h3-14H,1-2H3,(H,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 89n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368602
PNG
(US10227350, Compound 23)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccnc(N)c1)C(N)=O
Show InChI InChI=1S/C23H17ClN6O/c1-12-29-22-16(23(26)31)9-14(13-5-7-27-20(25)11-13)10-19(22)30(12)18-6-8-28-21-15(18)3-2-4-17(21)24/h2-11H,1H3,(H2,25,27)(H2,26,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 96n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368620
PNG
(US10227350, Compound 137 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccncc1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15ClFN7/c1-13-31-23-17(24-29-12-30-32-24)9-14(15-5-7-27-11-19(15)26)10-21(23)33(13)20-6-8-28-22-16(20)3-2-4-18(22)25/h2-12H,1H3,(H,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 99n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368612
PNG
(US10227350, Compound 33)
Show SMILES Cc1nnc([nH]1)-c1cc(cc2n(c(C)nc12)-c1ccnc2c(F)ccc(F)c12)-c1ccncc1
Show InChI InChI=1S/C25H17F2N7/c1-13-30-25(33-32-13)17-11-16(15-5-8-28-9-6-15)12-21-23(17)31-14(2)34(21)20-7-10-29-24-19(27)4-3-18(26)22(20)24/h3-12H,1-2H3,(H,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368710
PNG
(US10227350, Compound 125 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cccc(Cl)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H15ClN8/c1-14-32-24-18(25-30-13-31-33-25)10-16(15-5-7-28-17(9-15)12-27)11-22(24)34(14)21-6-8-29-20-4-2-3-19(26)23(20)21/h2-11,13H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368671
PNG
(US10227350, Compound 88)
Show SMILES Nc1nccc(-c2cc(-c3nnc[nH]3)c3nc(C4CC4)n(-c4ccnc5c(F)cccc45)c3c2)c1F
Show InChI InChI=1S/C26H18F2N8/c27-18-3-1-2-16-19(7-9-30-22(16)18)36-20-11-14(15-6-8-31-24(29)21(15)28)10-17(25-32-12-33-35-25)23(20)34-26(36)13-4-5-13/h1-3,6-13H,4-5H2,(H2,29,31)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368664
PNG
(US10227350, Compound 82)
Show SMILES CNc1cc(c(F)cn1)-c1cc(-c2nnc[nH]2)c2nc(C)n(-c3ccnc4c(F)ccc(F)c34)c2c1
Show InChI InChI=1S/C25H17F3N8/c1-12-34-23-15(25-32-11-33-35-25)7-13(14-9-21(29-2)31-10-18(14)28)8-20(23)36(12)19-5-6-30-24-17(27)4-3-16(26)22(19)24/h3-11H,1-2H3,(H,29,31)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 120n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368626
PNG
(US10227350, Compound 141 | US10227350, Compound 14...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(C)c1)-c1nnc[nH]1
Show InChI InChI=1S/C25H17F2N7/c1-13-9-15(5-7-28-13)16-10-17(25-30-12-31-33-25)23-21(11-16)34(14(2)32-23)20-6-8-29-24-19(27)4-3-18(26)22(20)24/h3-12H,1-2H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 120n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368748
PNG
(US10227350, Compound 163)
Show SMILES Nc1nccc(-c2ccc3ncn(-c4cc(nc5ccccc45)N4CCNCC4)c3c2)c1F
Show InChI InChI=1S/C25H22FN7/c26-24-17(7-8-29-25(24)27)16-5-6-20-22(13-16)33(15-30-20)21-14-23(32-11-9-28-10-12-32)31-19-4-2-1-3-18(19)21/h1-8,13-15,28H,9-12H2,(H2,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 120n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368647
PNG
(US10227350, Compound 66)
Show SMILES CC(C)c1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1)-c1nnc(C)[nH]1
Show InChI InChI=1S/C27H22ClFN8/c1-13(2)27-34-24-17(26-33-14(3)35-36-26)10-16(15-6-8-31-22(30)12-15)11-21(24)37(27)20-7-9-32-25-18(28)4-5-19(29)23(20)25/h4-13H,1-3H3,(H2,30,31)(H,33,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 140n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368594
PNG
(US10227350, Compound 15)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccnc(C)c1)C(N)=O
Show InChI InChI=1S/C24H18ClN5O/c1-13-10-15(6-8-27-13)16-11-18(24(26)31)23-21(12-16)30(14(2)29-23)20-7-9-28-22-17(20)4-3-5-19(22)25/h3-12H,1-2H3,(H2,26,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 150n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368596
PNG
(US10227350, Compound 17)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1)C(N)=O
Show InChI InChI=1S/C23H16F2N6O/c1-11-30-21-14(23(27)32)8-13(12-4-6-28-19(26)10-12)9-18(21)31(11)17-5-7-29-22-16(25)3-2-15(24)20(17)22/h2-10H,1H3,(H2,26,28)(H2,27,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 150n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368708
PNG
(US10227350, Compound 123 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(Cl)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14ClFN8/c1-13-33-23-17(25-31-12-32-34-25)9-15(14-4-6-29-16(8-14)11-28)10-21(23)35(13)20-5-7-30-24-19(27)3-2-18(26)22(20)24/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 160n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368630
PNG
(US10227350, Compound 49)
Show SMILES Cc1nnc([nH]1)-c1cc(cc2n(c(C)nc12)-c1ccnc2c(Cl)cccc12)-c1ccnc(N)c1
Show InChI InChI=1S/C25H19ClN8/c1-13-30-25(33-32-13)18-10-16(15-6-8-28-22(27)12-15)11-21-24(18)31-14(2)34(21)20-7-9-29-23-17(20)4-3-5-19(23)26/h3-12H,1-2H3,(H2,27,28)(H,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 170n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368634
PNG
(US10227350, Compound 53)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cc(F)ccc12)-c1ccnc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C24H17FN8/c1-13-31-23-18(24-29-12-30-32-24)8-15(14-4-6-28-22(26)10-14)9-21(23)33(13)20-5-7-27-19-11-16(25)2-3-17(19)20/h2-12H,1H3,(H2,26,28)(H,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 180n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368710
PNG
(US10227350, Compound 125 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cccc(Cl)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H15ClN8/c1-14-32-24-18(25-30-13-31-33-25)10-16(15-5-7-28-17(9-15)12-27)11-22(24)34(14)21-6-8-29-20-4-2-3-19(26)23(20)21/h2-11,13H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368645
PNG
(US10227350, Compound 64)
Show SMILES Cc1nnc([nH]1)-c1cc(cc2n(c(nc12)C1CC1)-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1
Show InChI InChI=1S/C27H20ClFN8/c1-13-33-26(36-35-13)17-10-16(15-6-8-31-22(30)12-15)11-21-24(17)34-27(14-2-3-14)37(21)20-7-9-32-25-18(28)4-5-19(29)23(20)25/h4-12,14H,2-3H2,1H3,(H2,30,31)(H,33,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368688
PNG
(US10227350, Compound 103 | US10227350, Compound 10...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C24H16F2N8/c1-12-32-22-15(24-30-11-31-33-24)8-14(13-4-6-28-20(27)10-13)9-19(22)34(12)18-5-7-29-23-17(26)3-2-16(25)21(18)23/h2-11H,1H3,(H2,27,28)(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 210n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368720
PNG
(US10227350, Compound 135 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14ClFN8/c1-13-33-23-17(25-31-12-32-34-25)9-15(14-4-6-29-16(8-14)11-28)10-21(23)35(13)20-5-7-30-24-18(26)2-3-19(27)22(20)24/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 220n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368617
PNG
(US10227350, Compound 36)
Show SMILES Clc1cccc2c(ccnc12)-n1c(nc2c(cc(cc12)-c1ccncc1)-c1nnc[nH]1)C1COC1
Show InChI InChI=1S/C26H18ClN7O/c27-20-3-1-2-18-21(6-9-29-23(18)20)34-22-11-16(15-4-7-28-8-5-15)10-19(25-30-14-31-33-25)24(22)32-26(34)17-12-35-13-17/h1-11,14,17H,12-13H2,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 250n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368640
PNG
(US10227350, Compound 59)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1cc(N)ncn1)-c1nnc[nH]1
Show InChI InChI=1S/C23H16ClN9/c1-12-31-22-15(23-29-11-30-32-23)7-13(17-9-20(25)28-10-27-17)8-19(22)33(12)18-5-6-26-21-14(18)3-2-4-16(21)24/h2-11H,1H3,(H2,25,27,28)(H,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 270n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368638
PNG
(US10227350, Compound 57)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1cc(N)nc(N)n1)-c1nnc[nH]1
Show InChI InChI=1S/C23H17ClN10/c1-11-30-21-14(22-28-10-29-33-22)7-12(16-9-19(25)32-23(26)31-16)8-18(21)34(11)17-5-6-27-20-13(17)3-2-4-15(20)24/h2-10H,1H3,(H,28,29,33)(H4,25,26,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 290n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368685
PNG
(US10227350, Compound 100)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1c(F)cnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H14F4N8/c1-10-34-21-12(24-32-9-33-35-24)6-11(18-15(27)8-31-23(29)20(18)28)7-17(21)36(10)16-4-5-30-22-14(26)3-2-13(25)19(16)22/h2-9H,1H3,(H2,29,31)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 320n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368633
PNG
(US10227350, Compound 52)
Show SMILES CCc1nc2c(cc(cc2n1-c1ccnc2cc(F)ccc12)-c1ccnc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C25H19FN8/c1-2-23-32-24-18(25-30-13-31-33-25)9-15(14-5-7-29-22(27)11-14)10-21(24)34(23)20-6-8-28-19-12-16(26)3-4-17(19)20/h3-13H,2H2,1H3,(H2,27,29)(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 330n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368673
PNG
(US10227350, Compound 90)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1cc(C)nc(N)c1)-c1nnc[nH]1
Show InChI InChI=1S/C25H18F2N8/c1-12-7-14(10-21(28)32-12)15-8-16(25-30-11-31-34-25)23-20(9-15)35(13(2)33-23)19-5-6-29-24-18(27)4-3-17(26)22(19)24/h3-11H,1-2H3,(H2,28,32)(H,30,31,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 340n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368591
PNG
(US10227350, Compound 12)
Show SMILES NC(=O)c1cc(cc2n(c(nc12)C1COC1)-c1ccnc2c(Cl)cccc12)-c1ccncc1
Show InChI InChI=1S/C25H18ClN5O2/c26-19-3-1-2-17-20(6-9-29-22(17)19)31-21-11-15(14-4-7-28-8-5-14)10-18(24(27)32)23(21)30-25(31)16-12-33-13-16/h1-11,16H,12-13H2,(H2,27,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 340n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368712
PNG
(US10227350, Compound 127 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)cccc12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H15FN8/c1-14-32-24-19(25-30-13-31-33-25)10-16(15-5-7-28-17(9-15)12-27)11-22(24)34(14)21-6-8-29-23-18(21)3-2-4-20(23)26/h2-11,13H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 360n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368718
PNG
(US10227350, Compound 133 | US10227350, Compound 13...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(F)c1)-c1nnc[nH]1
Show InChI InChI=1S/C24H14F3N7/c1-12-32-22-15(24-30-11-31-33-24)8-14(13-4-6-28-20(27)10-13)9-19(22)34(12)18-5-7-29-23-17(26)3-2-16(25)21(18)23/h2-11H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 400n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368641
PNG
(US10227350, Compound 60)
Show SMILES Nc1cc(ccn1)-c1cc(-c2nnc[nH]2)c2nc(C3CC3)n(-c3ccnc4c(F)cccc34)c2c1
Show InChI InChI=1S/C26H19FN8/c27-19-3-1-2-17-20(7-9-30-23(17)19)35-21-11-16(15-6-8-29-22(28)12-15)10-18(25-31-13-32-34-25)24(21)33-26(35)14-4-5-14/h1-3,6-14H,4-5H2,(H2,28,29)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 420n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368742
PNG
(US10227350, Compound 157)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ncnc(N)c1C#N)C(N)=O
Show InChI InChI=1S/C23H14F2N8O/c1-10-32-20-12(23(28)34)6-11(19-13(8-26)22(27)31-9-30-19)7-17(20)33(10)16-4-5-29-21-15(25)3-2-14(24)18(16)21/h2-7,9H,1H3,(H2,28,34)(H2,27,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 460n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368750
PNG
(US10227350, Compound 165)
Show SMILES Fc1nccc(c1F)-c1ccc2ncn(-c3cc(nc4ccccc34)N3CCNCC3)c2c1
Show InChI InChI=1S/C25H20F2N6/c26-24-17(7-8-29-25(24)27)16-5-6-20-22(13-16)33(15-30-20)21-14-23(32-11-9-28-10-12-32)31-19-4-2-1-3-18(19)21/h1-8,13-15,28H,9-12H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 480n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368724
PNG
(US10227350, Compound 139 | US10227350, Compound 14...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccncc1)-c1nnc[nH]1
Show InChI InChI=1S/C24H15F2N7/c1-13-31-22-16(24-29-12-30-32-24)10-15(14-4-7-27-8-5-14)11-20(22)33(13)19-6-9-28-23-18(26)3-2-17(25)21(19)23/h2-12H,1H3,(H,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 540n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368625
PNG
(US10227350, Compound 113 | US10227350, Compound 11...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H14F2N8/c1-13-33-23-17(25-31-12-32-34-25)9-15(14-4-6-29-16(8-14)11-28)10-21(23)35(13)20-5-7-30-24-19(27)3-2-18(26)22(20)24/h2-10,12H,1H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 560n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368710
PNG
(US10227350, Compound 125 | US10227350, Compound 12...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cccc(Cl)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1
Show InChI InChI=1S/C25H15ClN8/c1-14-32-24-18(25-30-13-31-33-25)10-16(15-5-7-28-17(9-15)12-27)11-22(24)34(14)21-6-8-29-20-4-2-3-19(26)23(20)21/h2-11,13H,1H3,(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 780n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368675
PNG
(US10227350, Compound 107 | US10227350, Compound 10...)
Show SMILES Cc1nc2c(cc(cc2n1-c1c(Cl)cnc2c(F)cccc12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15ClF2N8/c1-11-33-21-15(24-31-10-32-34-24)7-12(13-5-6-29-23(28)19(13)27)8-18(21)35(11)22-14-3-2-4-17(26)20(14)30-9-16(22)25/h2-10H,1H3,(H2,28,29)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 810n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368588
PNG
(US10227350, Compound 9)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2cccc(C)c12)-c1ccncc1)C(N)=O
Show InChI InChI=1S/C24H19N5O/c1-14-4-3-5-19-22(14)20(8-11-27-19)29-15(2)28-23-18(24(25)30)12-17(13-21(23)29)16-6-9-26-10-7-16/h3-13H,1-2H3,(H2,25,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 950n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368599
PNG
(US10227350, Compound 20)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ncnc2[nH]cnc12)C(N)=O
Show InChI InChI=1S/C23H15ClN8O/c1-11-31-20-14(22(25)33)7-12(18-21-23(29-9-27-18)30-10-28-21)8-17(20)32(11)16-5-6-26-19-13(16)3-2-4-15(19)24/h2-10H,1H3,(H2,25,33)(H,27,28,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368627
PNG
(US10227350, Compound 46)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(F)c1C)-c1nnc[nH]1
Show InChI InChI=1S/C25H16F3N7/c1-12-15(5-7-30-24(12)28)14-9-16(25-31-11-32-34-25)22-20(10-14)35(13(2)33-22)19-6-8-29-23-18(27)4-3-17(26)21(19)23/h3-11H,1-2H3,(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368601
PNG
(US10227350, Compound 22)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1cc(N)nc(N)n1)C(N)=O
Show InChI InChI=1S/C22H17ClN8O/c1-10-28-20-13(21(25)32)7-11(15-9-18(24)30-22(26)29-15)8-17(20)31(10)16-5-6-27-19-12(16)3-2-4-14(19)23/h2-9H,1H3,(H2,25,32)(H4,24,26,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368600
PNG
(US10227350, Compound 21)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1cc(N)ncn1)C(N)=O
Show InChI InChI=1S/C22H16ClN7O/c1-11-29-21-14(22(25)31)7-12(16-9-19(24)28-10-27-16)8-18(21)30(11)17-5-6-26-20-13(17)3-2-4-15(20)23/h2-10H,1H3,(H2,25,31)(H2,24,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368657
PNG
(US10227350, Compound 105 | US10227350, Compound 10...)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C24H15F3N8/c1-11-33-21-14(24-31-10-32-34-24)8-12(13-4-6-30-23(28)20(13)27)9-18(21)35(11)17-5-7-29-22-16(26)3-2-15(25)19(17)22/h2-10H,1H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
PDB
UniChem
US Patent
n/an/a 1.40E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368659
PNG
(US10227350, Compound 77)
Show SMILES CNc1nccc(-c2cc(-c3nnc[nH]3)c3nc(C)n(-c4ccnc5c(F)ccc(F)c45)c3c2)c1F
Show InChI InChI=1S/C25H17F3N8/c1-12-34-22-15(24-32-11-33-35-24)9-13(14-5-7-31-25(29-2)21(14)28)10-19(22)36(12)18-6-8-30-23-17(27)4-3-16(26)20(18)23/h3-11H,1-2H3,(H,29,31)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368589
PNG
(US10227350, Compound 10)
Show SMILES Cc1nc2c(cc(cc2n1-c1cc(C)nc2ccccc12)-c1ccncc1)C(N)=O
Show InChI InChI=1S/C24H19N5O/c1-14-11-21(18-5-3-4-6-20(18)27-14)29-15(2)28-23-19(24(25)30)12-17(13-22(23)29)16-7-9-26-10-8-16/h3-13H,1-2H3,(H2,25,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368683
PNG
(US10227350, Compound 111 | US10227350, Compound 11...)
Show SMILES Cc1nnc([nH]1)-c1cc(cc2n(c(C)nc12)-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1F
Show InChI InChI=1S/C25H17ClF2N8/c1-11-32-25(35-34-11)15-9-13(14-5-7-31-24(29)21(14)28)10-19-22(15)33-12(2)36(19)18-6-8-30-23-16(26)3-4-17(27)20(18)23/h3-10H,1-2H3,(H2,29,31)(H,32,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.50E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368680
PNG
(US10227350, Compound 109 | US10227350, Compound 11...)
Show SMILES CCc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1
Show InChI InChI=1S/C25H17F3N8/c1-2-19-34-22-14(25-32-11-33-35-25)9-12(13-5-7-31-24(29)21(13)28)10-18(22)36(19)17-6-8-30-23-16(27)4-3-15(26)20(17)23/h3-11H,2H2,1H3,(H2,29,31)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368686
PNG
(US10227350, Compound 101)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)-c1ccnc(N)c1C)-c1nnc[nH]1
Show InChI InChI=1S/C25H18F2N8/c1-12-15(5-7-30-24(12)28)14-9-16(25-31-11-32-34-25)22-20(10-14)35(13(2)33-22)19-6-8-29-23-18(27)4-3-17(26)21(19)23/h3-11H,1-2H3,(H2,28,30)(H,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.80E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM368582
PNG
(US10227350, Compound 3)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ncnc2[nH]cnc12)C(O)=O
Show InChI InChI=1S/C23H14ClN7O2/c1-11-30-20-14(23(32)33)7-12(18-21-22(28-9-26-18)29-10-27-21)8-17(20)31(11)16-5-6-25-19-13(16)3-2-4-15(19)24/h2-10H,1H3,(H,32,33)(H,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.80E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10227350 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%