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Patent code US10227357

Compile Data Set for Download or QSAR

Found 1107 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368989
PNG
(N-[3-fluoro-4-[6-methoxy-7-[3-(1- piperidyl)propox...)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCCCC1)-c1ccc(NS(=O)(=O)N2CCCC2)cc1F
Show InChI InChI=1S/C27H34FN5O4S/c1-36-25-17-22-24(18-26(25)37-15-7-12-32-10-3-2-4-11-32)29-19-30-27(22)21-9-8-20(16-23(21)28)31-38(34,35)33-13-5-6-14-33/h8-9,16-19,31H,2-7,10-15H2,1H3
PDB

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US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368990
PNG
(1,1,1-trideuterio-N-[3-fluoro-4-[6- methoxy-7-[3-(...)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCCCC1)-c1ccc(NS(C)(=O)=O)cc1F
Show InChI InChI=1S/C24H29FN4O4S/c1-32-22-14-19-21(15-23(22)33-12-6-11-29-9-4-3-5-10-29)26-16-27-24(19)18-8-7-17(13-20(18)25)28-34(2,30)31/h7-8,13-16,28H,3-6,9-12H2,1-2H3
PDB

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UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369000
PNG
(N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3-...)
Show SMILES COCCOc1cc2ncnc(-c3ccc(NS(C)(=O)=O)cc3F)c2cc1OCCOC
Show InChI InChI=1S/C21H24FN3O6S/c1-28-6-8-30-19-11-16-18(12-20(19)31-9-7-29-2)23-13-24-21(16)15-5-4-14(10-17(15)22)25-32(3,26)27/h4-5,10-13,25H,6-9H2,1-3H3
PDB

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UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342200
PNG
(4-[4-[5-(3-ethoxyphenyl)-4-methyl-1H- imidazol-2-y...)
Show SMILES CCOc1cccc(c1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1
Show InChI InChI=1S/C29H31N7O2/c1-4-38-22-7-5-6-21(14-22)26-18(2)33-27(35-26)19-9-12-36(13-10-19)29-23-16-24(34-28(23)31-17-32-29)20-8-11-30-25(15-20)37-3/h5-8,11,14-17,19H,4,9-10,12-13H2,1-3H3,(H,33,35)(H,31,32,34)
PDB

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369399
PNG
(N-[(1S)-1-(4-fluorophenyl)ethyl]-2,2- dimethyl-4-[...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(F)cc1
Show InChI InChI=1/C25H29FN8O/c1-16(17-5-7-19(26)8-6-17)30-24(35)34-10-9-33(14-25(34,2)3)23-20-11-21(18-12-29-32(4)13-18)31-22(20)27-15-28-23/h5-8,11-13,15-16H,9-10,14H2,1-4H3,(H,30,35)(H,27,28,31)/t16-/s2
PDB

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US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM368762
PNG
(4-[4-(1H-benzimidazol-2-yl)piperazin-1-yl]-6- (1-m...)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H21N9/c1-28-12-14(11-24-28)18-10-15-19(25-18)22-13-23-20(15)29-6-8-30(9-7-29)21-26-16-4-2-3-5-17(16)27-21/h2-5,10-13H,6-9H2,1H3,(H,26,27)(H,22,23,25)
PDB

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PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368762
PNG
(4-[4-(1H-benzimidazol-2-yl)piperazin-1-yl]-6- (1-m...)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H21N9/c1-28-12-14(11-24-28)18-10-15-19(25-18)22-13-23-20(15)29-6-8-30(9-7-29)21-26-16-4-2-3-5-17(16)27-21/h2-5,10-13H,6-9H2,1H3,(H,26,27)(H,22,23,25)
PDB

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PC sid
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US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368768
PNG
(N-[(1S)-1-[3-(dimethylamino)phenyl]ethyl]-4- [6-(4...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(c1)N(C)C
Show InChI InChI=1/C27H30FN7O/c1-18(20-5-4-6-22(15-20)33(2)3)31-27(36)35-13-11-34(12-14-35)26-23-16-24(32-25(23)29-17-30-26)19-7-9-21(28)10-8-19/h4-10,15-18H,11-14H2,1-3H3,(H,31,36)(H,29,30,32)/t18-/s2
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369028
PNG
(4-ethyl-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(C)cc12
Show InChI InChI=1S/C21H19FN4O2S/c1-3-14-4-7-16(8-5-14)29(27,28)26-15-6-9-17(19(22)11-15)20-18-10-13(2)25-21(18)24-12-23-20/h4-12,26H,3H2,1-2H3,(H,23,24,25)
PDB

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US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369030
PNG
(N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)ph...)
Show SMILES Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc3OCOc3c2)cc1
Show InChI InChI=1S/C20H16N4O4S/c1-12-8-16-19(21-10-22-20(16)23-12)13-2-4-14(5-3-13)24-29(25,26)15-6-7-17-18(9-15)28-11-27-17/h2-10,24H,11H2,1H3,(H,21,22,23)
PDB

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US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368785
PNG
(4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1/C26H24F4N6O/c1-16(18-3-2-4-19(13-18)26(28,29)30)33-25(37)36-11-9-35(10-12-36)24-21-14-22(34-23(21)31-15-32-24)17-5-7-20(27)8-6-17/h2-8,13-16H,9-12H2,1H3,(H,33,37)(H,31,32,34)/t16-/s2
PDB

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PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368793
PNG
((2S)-N-[(4-fluorophenyl)methyl]-2-methyl-4- [6-(4-...)
Show SMILES C[C@H]1CN(CCN1C(=O)NCc1ccc(F)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1
Show InChI InChI=1/C24H24FN7O/c1-16-14-31(10-11-32(16)24(33)27-13-17-2-4-19(25)5-3-17)23-20-12-21(18-6-8-26-9-7-18)30-22(20)28-15-29-23/h2-9,12,15-16H,10-11,13-14H2,1H3,(H,27,33)(H,28,29,30)/t16-/s2
PDB

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UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM368810
PNG
((2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-2- methyl-4-...)
Show SMILES C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccncc1)c1ccc(Cl)cc1
Show InChI InChI=1/C25H26ClN7O/c1-16-14-32(11-12-33(16)25(34)30-17(2)18-3-5-20(26)6-4-18)24-21-13-22(19-7-9-27-10-8-19)31-23(21)28-15-29-24/h3-10,13,15-17H,11-12,14H2,1-2H3,(H,30,34)(H,28,29,31)/t16-,17+/s2
PDB

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PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368812
PNG
((2R)-N-[(4-fluorophenyl)methyl]-2-methyl-4- [6-(4-...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCc1ccc(F)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1
Show InChI InChI=1/C24H24FN7O/c1-16-14-31(10-11-32(16)24(33)27-13-17-2-4-19(25)5-3-17)23-20-12-21(18-6-8-26-9-7-18)30-22(20)28-15-29-23/h2-9,12,15-16H,10-11,13-14H2,1H3,(H,27,33)(H,28,29,30)/t16-/s2
PDB

GoogleScholar
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PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368817
PNG
((2R)-N-(4-dimethylaminophenyl)-2-methyl-4- [6-(4-p...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Nc1ccc(cc1)N(C)C)c1ncnc2[nH]c(cc12)-c1ccncc1
Show InChI InChI=1/C25H28N8O/c1-17-15-32(12-13-33(17)25(34)29-19-4-6-20(7-5-19)31(2)3)24-21-14-22(18-8-10-26-11-9-18)30-23(21)27-16-28-24/h4-11,14,16-17H,12-13,15H2,1-3H3,(H,29,34)(H,27,28,30)/t17-/s2
PDB

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PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368831
PNG
(4-[6-(2-methylthiazol-5-yl)-7H-pyrrolo[2,3- d]pyri...)
Show SMILES Cc1ncc(s1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H20F3N7O2S/c1-13-26-11-18(35-13)17-10-16-19(30-17)27-12-28-20(16)31-6-8-32(9-7-31)21(33)29-14-2-4-15(5-3-14)34-22(23,24)25/h2-5,10-12H,6-9H2,1H3,(H,29,33)(H,27,28,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368835
PNG
(4-[6-(6-acetamido-3-pyridyl)-7H-pyrrolo[2,3- d]pyr...)
Show SMILES CC(=O)Nc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C25H23F3N8O3/c1-15(37)32-21-7-2-16(13-29-21)20-12-19-22(34-20)30-14-31-23(19)35-8-10-36(11-9-35)24(38)33-17-3-5-18(6-4-17)39-25(26,27)28/h2-7,12-14H,8-11H2,1H3,(H,33,38)(H,29,32,37)(H,30,31,34)
PDB

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PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM368864
PNG
(4-[6-[4-(1-cyanocyclopropyl)phenyl]-7H- pyrrolo[2,...)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(cc2)C2(CC2)C#N)cc1
Show InChI InChI=1S/C28H24F3N7O2/c29-28(30,31)40-21-7-5-20(6-8-21)35-26(39)38-13-11-37(12-14-38)25-22-15-23(36-24(22)33-17-34-25)18-1-3-19(4-2-18)27(16-32)9-10-27/h1-8,15,17H,9-14H2,(H,35,39)(H,33,34,36)
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM368868
PNG
(4-[6-(2-methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrim...)
Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C24H22F3N7O3/c1-36-20-12-15(6-7-28-20)19-13-18-21(32-19)29-14-30-22(18)33-8-10-34(11-9-33)23(35)31-16-2-4-17(5-3-16)37-24(25,26)27/h2-7,12-14H,8-11H2,1H3,(H,31,35)(H,29,30,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM368869
PNG
(4-[6-(6-methoxy-3-pyridyl)-7H-pyrrolo[2,3- d]pyrim...)
Show SMILES COc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C24H22F3N7O3/c1-36-20-7-2-15(13-28-20)19-12-18-21(32-19)29-14-30-22(18)33-8-10-34(11-9-33)23(35)31-16-3-5-17(6-4-16)37-24(25,26)27/h2-7,12-14H,8-11H2,1H3,(H,31,35)(H,29,30,32)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM369101
PNG
(1,1,1-trideuterio-N-[3-fluoro-4-[6-(4- fluoropheny...)
Show SMILES CS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C19H14F2N4O2S/c1-28(26,27)25-13-6-7-14(16(21)8-13)18-15-9-17(24-19(15)23-10-22-18)11-2-4-12(20)5-3-11/h2-10,25H,1H3,(H,22,23,24)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369117
PNG
(4-methyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidi...)
Show SMILES Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C20H18N4O2S/c1-13-3-9-17(10-4-13)27(25,26)24-16-7-5-15(6-8-16)19-18-11-14(2)23-20(18)22-12-21-19/h3-12,24H,1-2H3,(H,21,22,23)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369127
PNG
(N-[3-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C25H18F2N4O3S/c1-34-18-7-9-19(10-8-18)35(32,33)31-17-6-11-20(22(27)12-17)24-21-13-23(30-25(21)29-14-28-24)15-2-4-16(26)5-3-15/h2-14,31H,1H3,(H,28,29,30)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369128
PNG
(N-[2-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-...)
Show SMILES CCCS(=O)(=O)Nc1ccc(cc1F)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C21H18F2N4O2S/c1-2-9-30(28,29)27-18-8-5-14(10-17(18)23)20-16-11-19(26-21(16)25-12-24-20)13-3-6-15(22)7-4-13/h3-8,10-12,27H,2,9H2,1H3,(H,24,25,26)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369129
PNG
(4-fluoro-N-[4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-...)
Show SMILES Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C24H16F2N4O2S/c25-17-5-1-15(2-6-17)22-13-21-23(27-14-28-24(21)29-22)16-3-9-19(10-4-16)30-33(31,32)20-11-7-18(26)8-12-20/h1-14,30H,(H,27,28,29)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369143
PNG
(N-[4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimid...)
Show SMILES Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)C2CC2)cc1
Show InChI InChI=1S/C21H17FN4O2S/c22-15-5-1-13(2-6-15)19-11-18-20(23-12-24-21(18)25-19)14-3-7-16(8-4-14)26-29(27,28)17-9-10-17/h1-8,11-12,17,26H,9-10H2,(H,23,24,25)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369162
PNG
(4-methoxy-N-[4-(3-methyl-1H- pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]nc(C)c12
Show InChI InChI=1S/C19H17N5O3S/c1-12-17-18(20-11-21-19(17)23-22-12)13-3-5-14(6-4-13)24-28(25,26)16-9-7-15(27-2)8-10-16/h3-11,24H,1-2H3,(H,20,21,22,23)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368960
PNG
(N-(3-ethoxyphenyl)-4-[6-(3-pyridyl)-7H- pyrrolo[2,...)
Show SMILES Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)cc1
Show InChI InChI=1S/C23H22FN7O/c24-18-5-3-16(4-6-18)13-26-23(32)31-10-8-30(9-11-31)22-19-12-20(17-2-1-7-25-14-17)29-21(19)27-15-28-22/h1-7,12,14-15H,8-11,13H2,(H,26,32)(H,27,28,29)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368962
PNG
(4-[6-(3-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]...)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)cc1
Show InChI InChI=1S/C23H20F3N7O2/c24-23(25,26)35-17-5-3-16(4-6-17)30-22(34)33-10-8-32(9-11-33)21-18-12-19(15-2-1-7-27-13-15)31-20(18)28-14-29-21/h1-7,12-14H,8-11H2,(H,30,34)(H,28,29,31)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368986
PNG
(4-chloro-N-[3-fluoro-4-[7-methoxy-6- (3-morpholino...)
Show SMILES COc1cc2ncnc(-c3ccc(NS(=O)(=O)c4ccc(Cl)cc4)cc3F)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C28H28ClFN4O5S/c1-37-26-17-25-23(16-27(26)39-12-2-9-34-10-13-38-14-11-34)28(32-18-31-25)22-8-5-20(15-24(22)30)33-40(35,36)21-6-3-19(29)4-7-21/h3-8,15-18,33H,2,9-14H2,1H3
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM369240
PNG
(N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-[1- (cyclopr...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)C1CC1)c1cccc(Cl)c1
Show InChI InChI=1/C30H35ClN6O2S/c1-19(22-5-4-6-23(31)15-22)34-29(39)37-14-13-36(17-30(37,2)3)27-26-24(32-18-33-27)16-25(40-26)20-9-11-35(12-10-20)28(38)21-7-8-21/h4-6,9,15-16,18-19,21H,7-8,10-14,17H2,1-3H3,(H,34,39)/t19-/s2
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369243
PNG
(N-[4-[6-[1-(morpholine-4-carbonyl)-3,6- dihydro-2H...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)N1CCOCC1
Show InChI InChI=1S/C23H25N5O4S2/c1-34(30,31)26-18-4-2-17(3-5-18)21-22-19(24-15-25-21)14-20(33-22)16-6-8-27(9-7-16)23(29)28-10-12-32-13-11-28/h2-6,14-15,26H,7-13H2,1H3
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM369256
PNG
(N-[4-[6-[1-(cyclopropanecarbonyl)-3,6- dihydro-2H-...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C27H23FN4O3S2/c28-20-5-9-22(10-6-20)37(34,35)31-21-7-3-18(4-8-21)25-26-23(29-16-30-25)15-24(36-26)17-11-13-32(14-12-17)27(33)19-1-2-19/h3-11,15-16,19,31H,1-2,12-14H2
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369288
PNG
((2R)-N-[(4-fluorophenyl)methyl]-4-[6-(4- fluorophe...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCc1ccc(F)cc1)c1ncnc2cc(sc12)-c1ccc(F)cc1
Show InChI InChI=1/C25H23F2N5OS/c1-16-14-31(10-11-32(16)25(33)28-13-17-2-6-19(26)7-3-17)24-23-21(29-15-30-24)12-22(34-23)18-4-8-20(27)9-5-18/h2-9,12,15-16H,10-11,13-14H2,1H3,(H,28,33)/t16-/s2
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369299
PNG
(4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrim...)
Show SMILES Cc1nn(C)cc1-c1cc2ncnc(C3=CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1
Show InChI InChI=1S/C24H23FN6OS/c1-15-19(13-30(2)29-15)21-11-20-23(33-21)22(28-14-27-20)17-7-9-31(10-8-17)24(32)26-12-16-3-5-18(25)6-4-16/h3-7,11,13-14H,8-10,12H2,1-2H3,(H,26,32)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369333
PNG
((2R)-N-[(1S)-1-(4-chloro-3-methoxy- phenyl)ethyl]-...)
Show SMILES COc1cc(ccc1Cl)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1
Show InChI InChI=1/C27H28ClFN6O2/c1-16-14-34(10-11-35(16)27(36)32-17(2)19-6-9-22(28)24(12-19)37-3)26-21-13-23(33-25(21)30-15-31-26)18-4-7-20(29)8-5-18/h4-9,12-13,15-17H,10-11,14H2,1-3H3,(H,32,36)(H,30,31,33)/t16-,17+/s2
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369338
PNG
(N-[4-[6-(2-methoxy-4-pyridyl)-7H- pyrrolo[2,3-d]py...)
Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)C1=CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1/C25H22F3N5O4S/c1-36-22-12-16(10-11-29-22)21-13-20-23(30-14-31-24(20)32-21)15-2-4-17(5-3-15)33-38(34,35)19-8-6-18(7-9-19)37-25(26,27)28/h2,6-14,17,33H,3-5H2,1H3,(H,30,31,32)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM369349
PNG
(5-ethyl-N-[1-[6-(1-methylpyrazol-4-yl)- 7H-pyrrolo...)
Show SMILES CCc1ccc(s1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C21H25N7O2S2/c1-3-16-4-5-19(31-16)32(29,30)26-15-6-8-28(9-7-15)21-17-10-18(14-11-24-27(2)12-14)25-20(17)22-13-23-21/h4-5,10-13,15,26H,3,6-9H2,1-2H3,(H,22,23,25)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369359
PNG
(4-ethyl-N-[1-[6-(1-methylpyrazol-4-yl)- 7H-pyrrolo...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C23H27N7O2S/c1-3-16-4-6-19(7-5-16)33(31,32)28-18-8-10-30(11-9-18)23-20-12-21(17-13-26-29(2)14-17)27-22(20)24-15-25-23/h4-7,12-15,18,28H,3,8-11H2,1-2H3,(H,24,25,27)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369374
PNG
((2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6- (4-cya...)
Show SMILES C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1ccc(Cl)cc1
Show InChI InChI=1/C27H26ClN7O/c1-17-15-34(11-12-35(17)27(36)32-18(2)20-7-9-22(28)10-8-20)26-23-13-24(33-25(23)30-16-31-26)21-5-3-19(14-29)4-6-21/h3-10,13,16-18H,11-12,15H2,1-2H3,(H,32,36)(H,30,31,33)/t17-,18+/s2
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369391
PNG
((2R)-4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrim...)
Show SMILES C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(C)cc1
Show InChI InChI=1/C27H29FN6O/c1-17-4-6-20(7-5-17)19(3)31-27(35)34-13-12-33(15-18(34)2)26-23-14-24(32-25(23)29-16-30-26)21-8-10-22(28)11-9-21/h4-11,14,16,18-19H,12-13,15H2,1-3H3,(H,31,35)(H,29,30,32)/t18-,19+/s2
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368988
PNG
(N-[3-fluoro-4-[7-methoxy-6-(3- morpholinopropoxy)q...)
Show SMILES COc1cc2ncnc(-c3ccc(NS(C)(=O)=O)cc3F)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C23H27FN4O5S/c1-31-21-14-20-18(13-22(21)33-9-3-6-28-7-10-32-11-8-28)23(26-15-25-20)17-5-4-16(12-19(17)24)27-34(2,29)30/h4-5,12-15,27H,3,6-11H2,1-2H3
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369396
PNG
((2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-2- methyl-4-...)
Show SMILES C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1/C24H27ClN8O/c1-15-12-32(8-9-33(15)24(34)29-16(2)17-4-6-19(25)7-5-17)23-20-10-21(18-11-28-31(3)13-18)30-22(20)26-14-27-23/h4-7,10-11,13-16H,8-9,12H2,1-3H3,(H,29,34)(H,26,27,30)/t15-,16+/s2
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369401
PNG
(N-[(1S)-1-(4-chlorophenyl)ethyl]-2,2- dimethyl-4-[...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1/C25H29ClN8O/c1-16(17-5-7-19(26)8-6-17)30-24(35)34-10-9-33(14-25(34,2)3)23-20-11-21(18-12-29-32(4)13-18)31-22(20)27-15-28-23/h5-8,11-13,15-16H,9-10,14H2,1-4H3,(H,30,35)(H,27,28,31)/t16-/s2
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM369402
PNG
(N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(1,3- dimeth...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C)c1ccc(Cl)cc1
Show InChI InChI=1/C26H31ClN8O/c1-16(18-6-8-19(27)9-7-18)30-25(36)35-11-10-34(14-26(35,3)4)24-20-12-22(31-23(20)28-15-29-24)21-13-33(5)32-17(21)2/h6-9,12-13,15-16H,10-11,14H2,1-5H3,(H,30,36)(H,28,29,31)/t16-/s2
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM369406
PNG
(4-ethyl-N-[1-[6-(2-methoxy-4-pyridyl)- 7H-pyrrolo[...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1
Show InChI InChI=1S/C25H28N6O3S/c1-3-17-4-6-20(7-5-17)35(32,33)30-19-9-12-31(13-10-19)25-21-15-22(29-24(21)27-16-28-25)18-8-11-26-23(14-18)34-2/h4-8,11,14-16,19,30H,3,9-10,12-13H2,1-2H3,(H,27,28,29)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368757
PNG
(N-[(1S)-1-(3-fluorophenyl)ethyl]-4-[6-(4- fluoroph...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(F)c1
Show InChI InChI=1/C27H28F2N6O/c1-17(19-5-4-6-21(29)13-19)32-26(36)35-12-11-34(15-27(35,2)3)25-22-14-23(33-24(22)30-16-31-25)18-7-9-20(28)10-8-18/h4-10,13-14,16-17H,11-12,15H2,1-3H3,(H,32,36)(H,30,31,33)/t17-/s2
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368758
PNG
(N-[(1S)-1-[3-(difluoromethoxy)phenyl]ethyl]- 4-[6-...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(OC(F)F)c1
Show InChI InChI=1/C28H29F3N6O2/c1-17(19-5-4-6-21(13-19)39-26(30)31)34-27(38)37-12-11-36(15-28(37,2)3)25-22-14-23(35-24(22)32-16-33-25)18-7-9-20(29)10-8-18/h4-10,13-14,16-17,26H,11-12,15H2,1-3H3,(H,34,38)(H,32,33,35)/t17-/s2
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368765
PNG
(4-[4-(1H-benzimidazol-2-yl)piperazin-1-yl]-6- (6-m...)
Show SMILES Cc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H22N8/c1-15-6-7-16(13-24-15)20-12-17-21(27-20)25-14-26-22(17)30-8-10-31(11-9-30)23-28-18-4-2-3-5-19(18)29-23/h2-7,12-14H,8-11H2,1H3,(H,28,29)(H,25,26,27)
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368774
PNG
((2R)-4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrim...)
Show SMILES C[C@@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1)c1ccc(F)cc1
Show InChI InChI=1/C26H26ClFN6O/c1-16-14-33(11-12-34(16)26(35)31-17(2)18-5-9-21(28)10-6-18)25-22-13-23(32-24(22)29-15-30-25)19-3-7-20(27)8-4-19/h3-10,13,15-17H,11-12,14H2,1-2H3,(H,31,35)(H,29,30,32)/t16-,17-/s2
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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
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