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Patent code US10227360

Compile Data Set for Download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM368971
PNG
(4-(4-((2-(5-(1-Cyanocyclopropyl)thiophen-2-yl)-5-f...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc(s2)C2(CC2)C#N)cc1
Show InChI InChI=1S/C25H22FNO3S/c26-19-6-9-21(22-10-11-23(31-22)25(16-27)12-13-25)18(14-19)15-30-20-7-4-17(5-8-20)2-1-3-24(28)29/h4-11,14H,1-3,12-13,15H2,(H,28,29)
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US Patent


Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369445
PNG
(4-(4-((5-Fluoro-2-(5-methoxy-5-methyl-5,6,7,8-tetr...)
Show SMILES COC1(C)CCCc2cc(ccc12)-c1ccc(F)cc1COc1ccc(CCCC(O)=O)cc1
Show InChI InChI=1/C29H31FO4/c1-29(33-2)16-4-6-22-17-21(10-15-27(22)29)26-14-11-24(30)18-23(26)19-34-25-12-8-20(9-13-25)5-3-7-28(31)32/h8-15,17-18H,3-7,16,19H2,1-2H3,(H,31,32)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369418
PNG
(4-(4-((5-Fluoro-2-(5-(1-hydroxycyclobutyl)thiophen...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc(s2)C2(O)CCC2)cc1
Show InChI InChI=1S/C25H25FO4S/c26-19-7-10-21(22-11-12-23(31-22)25(29)13-2-14-25)18(15-19)16-30-20-8-5-17(6-9-20)3-1-4-24(27)28/h5-12,15,29H,1-4,13-14,16H2,(H,27,28)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369438
PNG
(4-(4-((2-(4-Cyclopropylthiazol-5-yl)-5-fluorobenzy...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2scnc2C2CC2)cc1
Show InChI InChI=1S/C23H22FNO3S/c24-18-8-11-20(23-22(16-6-7-16)25-14-29-23)17(12-18)13-28-19-9-4-15(5-10-19)2-1-3-21(26)27/h4-5,8-12,14,16H,1-3,6-7,13H2,(H,26,27)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369454
PNG
(4-(4-((2-(6,7-Dihydro-4H-pyrano[4,3-d]thiazol-2-yl...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2nc3CCOCc3s2)cc1
Show InChI InChI=1S/C23H22FNO4S/c24-17-6-9-19(23-25-20-10-11-28-14-21(20)30-23)16(12-17)13-29-18-7-4-15(5-8-18)2-1-3-22(26)27/h4-9,12H,1-3,10-11,13-14H2,(H,26,27)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369410
PNG
(4-(4-((4'-(1-Cyanocyclopropyl)-4-fluoro-[1,1'-biph...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc(cc2)C2(CC2)C#N)cc1
Show InChI InChI=1S/C27H24FNO3/c28-23-10-13-25(20-6-8-22(9-7-20)27(18-29)14-15-27)21(16-23)17-32-24-11-4-19(5-12-24)2-1-3-26(30)31/h4-13,16H,1-3,14-15,17H2,(H,30,31)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369414
PNG
(4-(4-((2-(2,3-Dihydro-1H-inden-5-yl)-5-fluorobenzy...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C26H25FO3/c27-23-11-14-25(21-10-9-19-4-2-5-20(19)15-21)22(16-23)17-30-24-12-7-18(8-13-24)3-1-6-26(28)29/h7-16H,1-6,17H2,(H,28,29)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369428
PNG
(4-(4-((2-(2,3-Dihydrobenzofuran-5-yl)-5-fluorobenz...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc3OCCc3c2)cc1
Show InChI InChI=1S/C25H23FO4/c26-21-7-10-23(18-6-11-24-19(14-18)12-13-29-24)20(15-21)16-30-22-8-4-17(5-9-22)2-1-3-25(27)28/h4-11,14-15H,1-3,12-13,16H2,(H,27,28)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369411
PNG
(3-(4-((4'-(1-Cyanocyclopropyl)-4-fluoro-[1,1'-biph...)
Show SMILES OC(=O)CCc1ccc(OCc2cc(F)ccc2-c2ccc(cc2)C2(CC2)C#N)cc1
Show InChI InChI=1S/C26H22FNO3/c27-22-8-11-24(19-4-6-21(7-5-19)26(17-28)13-14-26)20(15-22)16-31-23-9-1-18(2-10-23)3-12-25(29)30/h1-2,4-11,15H,3,12-14,16H2,(H,29,30)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369413
PNG
(4-(4-((4'-Cyclopropyl-4-fluoro-[1,1'-biphenyl]-2-y...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc(cc2)C2CC2)cc1
Show InChI InChI=1S/C26H25FO3/c27-23-12-15-25(21-10-8-20(9-11-21)19-6-7-19)22(16-23)17-30-24-13-4-18(5-14-24)2-1-3-26(28)29/h4-5,8-16,19H,1-3,6-7,17H2,(H,28,29)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369419
PNG
(3-(4-((4-Fluoro-4'-(oxetan-3-yl)-[1,1'-biphenyl]-2...)
Show SMILES OC(=O)CCc1ccc(OCc2cc(F)ccc2-c2ccc(cc2)C2COC2)cc1
Show InChI InChI=1S/C25H23FO4/c26-22-8-11-24(19-6-4-18(5-7-19)21-14-29-15-21)20(13-22)16-30-23-9-1-17(2-10-23)3-12-25(27)28/h1-2,4-11,13,21H,3,12,14-16H2,(H,27,28)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369420
PNG
(3-(4-((4-Fluoro-4'-(1-hydroxycyclobutyl)-[1,1'-bip...)
Show SMILES OC(=O)CCc1ccc(OCc2cc(F)ccc2-c2ccc(cc2)C2(O)CCC2)cc1
Show InChI InChI=1S/C26H25FO4/c27-22-9-12-24(19-5-7-21(8-6-19)26(30)14-1-15-26)20(16-22)17-31-23-10-2-18(3-11-23)4-13-25(28)29/h2-3,5-12,16,30H,1,4,13-15,17H2,(H,28,29)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369424
PNG
(3-(5-((4'-(1-Cyanocyclopropyl)-4-fluoro-[1,1'-biph...)
Show SMILES OC(=O)CCc1ccc(OCc2cc(F)ccc2-c2ccc(cc2)C2(CC2)C#N)cn1
Show InChI InChI=1S/C25H21FN2O3/c26-20-5-9-23(17-1-3-19(4-2-17)25(16-27)11-12-25)18(13-20)15-31-22-8-6-21(28-14-22)7-10-24(29)30/h1-6,8-9,13-14H,7,10-12,15H2,(H,29,30)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369425
PNG
(4-(4-((4-(4-(1-Cyanocyclopropyl)phenyl)pyridin-3-y...)
Show SMILES OC(=O)CCCc1ccc(OCc2cnccc2-c2ccc(cc2)C2(CC2)C#N)cc1
Show InChI InChI=1S/C26H24N2O3/c27-18-26(13-14-26)22-8-6-20(7-9-22)24-12-15-28-16-21(24)17-31-23-10-4-19(5-11-23)2-1-3-25(29)30/h4-12,15-16H,1-3,13-14,17H2,(H,29,30)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369430
PNG
(4-(4-((2-(6,7-Dihydro-5H-cyclopenta[b]pyridin-3-yl...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2cnc3CCCc3c2)cc1
Show InChI InChI=1S/C25H24FNO3/c26-21-9-12-23(19-13-18-4-2-5-24(18)27-15-19)20(14-21)16-30-22-10-7-17(8-11-22)3-1-6-25(28)29/h7-15H,1-6,16H2,(H,28,29)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369431
PNG
(4-(4-((5-Fluoro-2-(7-methylene-4,5,6,7-tetrahydrob...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2nc3CCCC(=C)c3s2)cc1
Show InChI InChI=1S/C25H24FNO3S/c1-16-4-2-6-22-24(16)31-25(27-22)21-13-10-19(26)14-18(21)15-30-20-11-8-17(9-12-20)5-3-7-23(28)29/h8-14H,1-7,15H2,(H,28,29)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369437
PNG
(4-(4-((2-(2-Cyclopropylpyrimidin-5-yl)-5-fluoroben...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2cnc(nc2)C2CC2)cc1
Show InChI InChI=1S/C24H23FN2O3/c25-20-8-11-22(19-13-26-24(27-14-19)17-6-7-17)18(12-20)15-30-21-9-4-16(5-10-21)2-1-3-23(28)29/h4-5,8-14,17H,1-3,6-7,15H2,(H,28,29)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369442
PNG
(4-(4-((5-Fluoro-2-(5-methylene-5,6,7,8-tetrahydron...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc3C(=C)CCCc3c2)cc1
Show InChI InChI=1S/C28H27FO3/c1-19-4-2-6-21-16-22(10-14-26(19)21)27-15-11-24(29)17-23(27)18-32-25-12-8-20(9-13-25)5-3-7-28(30)31/h8-17H,1-7,18H2,(H,30,31)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369444
PNG
(4-(4-((5-Fluoro-2-(5-methoxy-5,6,7,8-tetrahydronap...)
Show SMILES COC1CCCc2cc(ccc12)-c1ccc(F)cc1COc1ccc(CCCC(O)=O)cc1
Show InChI InChI=1/C28H29FO4/c1-32-27-6-3-5-20-16-21(10-14-26(20)27)25-15-11-23(29)17-22(25)18-33-24-12-8-19(9-13-24)4-2-7-28(30)31/h8-17,27H,2-7,18H2,1H3,(H,30,31)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369447
PNG
(4-(4-((5-Fluoro-2-(5,6,7,8-tetrahydro-4H-cyclohept...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2nc3CCCCCc3s2)cc1
Show InChI InChI=1S/C25H26FNO3S/c26-19-11-14-21(25-27-22-6-2-1-3-7-23(22)31-25)18(15-19)16-30-20-12-9-17(10-13-20)5-4-8-24(28)29/h9-15H,1-8,16H2,(H,28,29)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369449
PNG
(4-(4-((4'-(2,2-Difluorocyclopropyl)-4-fluoro-[1,1'...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc(cc2)C2CC2(F)F)cc1
Show InChI InChI=1/C26H23F3O3/c27-21-10-13-23(18-6-8-19(9-7-18)24-15-26(24,28)29)20(14-21)16-32-22-11-4-17(5-12-22)2-1-3-25(30)31/h4-14,24H,1-3,15-16H2,(H,30,31)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369452
PNG
(4-(4-((5-Fluoro-2-(4,5,6,7-tetrahydrobenzo[d]thiaz...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2nc3CCCCc3s2)cc1
Show InChI InChI=1S/C24H24FNO3S/c25-18-10-13-20(24-26-21-5-1-2-6-22(21)30-24)17(14-18)15-29-19-11-8-16(9-12-19)4-3-7-23(27)28/h8-14H,1-7,15H2,(H,27,28)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369412
PNG
(3-(4-((2-(6-(1-Cyanocyclopropyl)pyridin-3-yl)-5-fl...)
Show SMILES OC(=O)CCc1ccc(OCc2cc(F)ccc2-c2ccc(nc2)C2(CC2)C#N)cc1
Show InChI InChI=1S/C25H21FN2O3/c26-20-5-8-22(18-4-9-23(28-14-18)25(16-27)11-12-25)19(13-20)15-31-21-6-1-17(2-7-21)3-10-24(29)30/h1-2,4-9,13-14H,3,10-12,15H2,(H,29,30)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369417
PNG
(4-(4-((2-(5-Cyclopropylthiophen-2-yl)-5-fluorobenz...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc(s2)C2CC2)cc1
Show InChI InChI=1S/C24H23FO3S/c25-19-8-11-21(23-13-12-22(29-23)17-6-7-17)18(14-19)15-28-20-9-4-16(5-10-20)2-1-3-24(26)27/h4-5,8-14,17H,1-3,6-7,15H2,(H,26,27)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369448
PNG
(4-(4-((5-Fluoro-2-(5-(1-fluorocyclopropyl)thiophen...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc(s2)C2(F)CC2)cc1
Show InChI InChI=1S/C24H22F2O3S/c25-18-6-9-20(21-10-11-22(30-21)24(26)12-13-24)17(14-18)15-29-19-7-4-16(5-8-19)2-1-3-23(27)28/h4-11,14H,1-3,12-13,15H2,(H,27,28)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369393
PNG
(4-(4-((4-Fluoro-4'-(1-methylcyclopropyl)-[1,1'-bip...)
Show SMILES CC1(CC1)c1ccc(cc1)-c1ccc(F)cc1COc1ccc(CCCC(O)=O)cc1
Show InChI InChI=1S/C27H27FO3/c1-27(15-16-27)22-9-7-20(8-10-22)25-14-11-23(28)17-21(25)18-31-24-12-5-19(6-13-24)3-2-4-26(29)30/h5-14,17H,2-4,15-16,18H2,1H3,(H,29,30)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369421
PNG
(3-(4-((4'-(5,5-Dimethylcyclopent-1-en-1-yl)-4-fluo...)
Show SMILES CC1(C)CCC=C1c1ccc(cc1)-c1ccc(F)cc1COc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C29H29FO3/c1-29(2)17-3-4-27(29)22-10-8-21(9-11-22)26-15-12-24(30)18-23(26)19-33-25-13-5-20(6-14-25)7-16-28(31)32/h4-6,8-15,18H,3,7,16-17,19H2,1-2H3,(H,31,32)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369440
PNG
(4-(4-((5-Fluoro-2-(5-oxo-5,6,7,8-tetrahydronaphtha...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc3C(=O)CCCc3c2)cc1
Show InChI InChI=1S/C27H25FO4/c28-22-10-14-24(20-9-13-25-19(15-20)4-2-5-26(25)29)21(16-22)17-32-23-11-7-18(8-12-23)3-1-6-27(30)31/h7-16H,1-6,17H2,(H,30,31)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369450
PNG
(4-(4-((2-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-5-f...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2nnc(s2)C2CC2)cc1
Show InChI InChI=1S/C22H21FN2O3S/c23-17-8-11-19(22-25-24-21(29-22)15-6-7-15)16(12-17)13-28-18-9-4-14(5-10-18)2-1-3-20(26)27/h4-5,8-12,15H,1-3,6-7,13H2,(H,26,27)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369453
PNG
(4-(4-((2-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2nc3CCCc3s2)cc1
Show InChI InChI=1S/C23H22FNO3S/c24-17-9-12-19(23-25-20-4-2-5-21(20)29-23)16(13-17)14-28-18-10-7-15(8-11-18)3-1-6-22(26)27/h7-13H,1-6,14H2,(H,26,27)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369454
PNG
(4-(4-((2-(6,7-Dihydro-4H-pyrano[4,3-d]thiazol-2-yl...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2nc3CCOCc3s2)cc1
Show InChI InChI=1S/C23H22FNO4S/c24-17-6-9-19(23-25-20-10-11-28-14-21(20)30-23)16(12-17)13-29-18-7-4-15(5-8-18)2-1-3-22(26)27/h4-9,12H,1-3,10-11,13-14H2,(H,26,27)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369456
PNG
(4-(4-((2-(4-Cyclopropylthiazol-2-yl)-5-fluorobenzy...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2nc(cs2)C2CC2)cc1
Show InChI InChI=1S/C23H22FNO3S/c24-18-8-11-20(23-25-21(14-29-23)16-6-7-16)17(12-18)13-28-19-9-4-15(5-10-19)2-1-3-22(26)27/h4-5,8-12,14,16H,1-3,6-7,13H2,(H,26,27)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369426
PNG
(3-(5-((2-(Bicyclo[4.2.0]octa-1(6),2,4-trien-3-yl)-...)
Show SMILES OC(=O)CCc1ccc(OCc2cc(F)ccc2-c2ccc3CCc3c2)cn1
Show InChI InChI=1S/C23H20FNO3/c24-19-5-9-22(17-4-2-15-1-3-16(15)11-17)18(12-19)14-28-21-8-6-20(25-13-21)7-10-23(26)27/h2,4-6,8-9,11-13H,1,3,7,10,14H2,(H,26,27)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369427
PNG
(3-(4-((2-(4-(1-Cyanocyclopropyl)phenyl)pyridin-3-y...)
Show SMILES OC(=O)CCc1ccc(OCc2cccnc2-c2ccc(cc2)C2(CC2)C#N)cc1
Show InChI InChI=1S/C25H22N2O3/c26-17-25(13-14-25)21-8-6-19(7-9-21)24-20(2-1-15-27-24)16-30-22-10-3-18(4-11-22)5-12-23(28)29/h1-4,6-11,15H,5,12-14,16H2,(H,28,29)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369435
PNG
(4-(4-((4'-cyclopropyl-4-fluoro-3'-methyl-[1,1'-bip...)
Show SMILES Cc1cc(ccc1C1CC1)-c1ccc(F)cc1COc1ccc(CCCC(O)=O)cc1
Show InChI InChI=1S/C27H27FO3/c1-18-15-21(9-13-25(18)20-7-8-20)26-14-10-23(28)16-22(26)17-31-24-11-5-19(6-12-24)3-2-4-27(29)30/h5-6,9-16,20H,2-4,7-8,17H2,1H3,(H,29,30)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369446
PNG
(4-(4-((5-Fluoro-2-(5-(1-methylcyclopropyl)thiophen...)
Show SMILES CC1(CC1)c1ccc(s1)-c1ccc(F)cc1COc1ccc(CCCC(O)=O)cc1
Show InChI InChI=1S/C25H25FO3S/c1-25(13-14-25)23-12-11-22(30-23)21-10-7-19(26)15-18(21)16-29-20-8-5-17(6-9-20)3-2-4-24(27)28/h5-12,15H,2-4,13-14,16H2,1H3,(H,27,28)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369451
PNG
(4-(4-((2-(5-Cyclopropylthiazol-2-yl)-5-fluorobenzy...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ncc(s2)C2CC2)cc1
Show InChI InChI=1S/C23H22FNO3S/c24-18-8-11-20(23-25-13-21(29-23)16-6-7-16)17(12-18)14-28-19-9-4-15(5-10-19)2-1-3-22(26)27/h4-5,8-13,16H,1-3,6-7,14H2,(H,26,27)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369416
PNG
(4-(4-((2-(Bicyclo[4.2.0]octa-1(6),2,4-trien-3-yl)-...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc3CCc3c2)cc1
Show InChI InChI=1S/C25H23FO3/c26-22-10-13-24(20-9-7-18-6-8-19(18)14-20)21(15-22)16-29-23-11-4-17(5-12-23)2-1-3-25(27)28/h4-5,7,9-15H,1-3,6,8,16H2,(H,27,28)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369432
PNG
(4-(4-((2-(Bicyclo[4.2.0]octa-1(6),2,4-trien-3-yl)b...)
Show SMILES OC(=O)CCCc1ccc(OCc2ccccc2-c2ccc3CCc3c2)cc1
Show InChI InChI=1S/C25H24O3/c26-25(27)7-3-4-18-8-14-23(15-9-18)28-17-22-5-1-2-6-24(22)21-13-11-19-10-12-20(19)16-21/h1-2,5-6,8-9,11,13-16H,3-4,7,10,12,17H2,(H,26,27)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369433
PNG
(4-(4-((2-(5,6,7,8-tetrahydronaphthalen-2-yl)benzyl...)
Show SMILES OC(=O)CCCc1ccc(OCc2ccccc2-c2ccc3CCCCc3c2)cc1
Show InChI InChI=1S/C27H28O3/c28-27(29)11-5-6-20-12-16-25(17-13-20)30-19-24-9-3-4-10-26(24)23-15-14-21-7-1-2-8-22(21)18-23/h3-4,9-10,12-18H,1-2,5-8,11,19H2,(H,28,29)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369434
PNG
(4-(4-((2-(5-Cyclobutylthiophen-2-yl)-5-fluorobenzy...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc(s2)C2CCC2)cc1
Show InChI InChI=1S/C25H25FO3S/c26-20-9-12-22(24-14-13-23(30-24)18-4-2-5-18)19(15-20)16-29-21-10-7-17(8-11-21)3-1-6-25(27)28/h7-15,18H,1-6,16H2,(H,27,28)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369439
PNG
(4-(4-((2-(2,3-Dihydro-1H-inden-5-yl)benzyl)oxy)phe...)
Show SMILES OC(=O)CCCc1ccc(OCc2ccccc2-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C26H26O3/c27-26(28)10-3-5-19-11-15-24(16-12-19)29-18-23-6-1-2-9-25(23)22-14-13-20-7-4-8-21(20)17-22/h1-2,6,9,11-17H,3-5,7-8,10,18H2,(H,27,28)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369441
PNG
(4-(4-((2-(7,8-Dihydronaphthalen-2-yl)-5-fluorobenz...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc3C=CCCc3c2)cc1
Show InChI InChI=1S/C27H25FO3/c28-24-12-15-26(22-11-10-20-5-1-2-6-21(20)16-22)23(17-24)18-31-25-13-8-19(9-14-25)4-3-7-27(29)30/h1,5,8-17H,2-4,6-7,18H2,(H,29,30)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369231
PNG
(3-(4-((2-(5-(1-Cyanocyclopropyl)thiophen-2-yl)-5-f...)
Show SMILES OC(=O)CCc1ccc(OCc2cc(F)ccc2-c2ccc(s2)C2(CC2)C#N)cc1
Show InChI InChI=1S/C24H20FNO3S/c25-18-4-7-20(21-8-9-22(30-21)24(15-26)11-12-24)17(13-18)14-29-19-5-1-16(2-6-19)3-10-23(27)28/h1-2,4-9,13H,3,10-12,14H2,(H,27,28)
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n/an/an/an/a 2.75E+3n/an/an/an/a



Piramal Enterprises Limited

US Patent


Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369422
PNG
(4-(4-((4'-Cyclohexyl-4-fluoro-[1,1'-biphenyl]-2-yl...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc(cc2)C2CCCCC2)cc1
Show InChI InChI=1S/C29H31FO3/c30-26-15-18-28(24-13-11-23(12-14-24)22-6-2-1-3-7-22)25(19-26)20-33-27-16-9-21(10-17-27)5-4-8-29(31)32/h9-19,22H,1-8,20H2,(H,31,32)
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Piramal Enterprises Limited

US Patent


Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369423
PNG
(3-(4-((5-Fluoro-2-(6-(oxetan-3-yl)pyridin-3-yl)ben...)
Show SMILES OC(=O)CCc1ccc(OCc2cc(F)ccc2-c2ccc(nc2)C2COC2)cc1
Show InChI InChI=1S/C24H22FNO4/c25-20-5-8-22(17-4-9-23(26-12-17)19-13-29-14-19)18(11-20)15-30-21-6-1-16(2-7-21)3-10-24(27)28/h1-2,4-9,11-12,19H,3,10,13-15H2,(H,27,28)
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US Patent


Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369429
PNG
(4-(4-((5-Fluoro-2-(4,5,6,7-tetrahydrobenzo[b]thiop...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2cc3CCCCc3s2)cc1
Show InChI InChI=1S/C25H25FO3S/c26-20-10-13-22(24-15-18-5-1-2-6-23(18)30-24)19(14-20)16-29-21-11-8-17(9-12-21)4-3-7-25(27)28/h8-15H,1-7,16H2,(H,27,28)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369436
PNG
(4-(4-((2-(6-Cyclopropylpyridin-3-yl)-5-fluorobenzy...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc(nc2)C2CC2)cc1
Show InChI InChI=1S/C25H24FNO3/c26-21-9-12-23(19-8-13-24(27-15-19)18-6-7-18)20(14-21)16-30-22-10-4-17(5-11-22)2-1-3-25(28)29/h4-5,8-15,18H,1-3,6-7,16H2,(H,28,29)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369443
PNG
(4-(4-((5-Fluoro-2-(5-methyl-7,8-dihydronaphthalen-...)
Show SMILES CC1=CCCc2cc(ccc12)-c1ccc(F)cc1COc1ccc(CCCC(O)=O)cc1
Show InChI InChI=1S/C28H27FO3/c1-19-4-2-6-21-16-22(10-14-26(19)21)27-15-11-24(29)17-23(27)18-32-25-12-8-20(9-13-25)5-3-7-28(30)31/h4,8-17H,2-3,5-7,18H2,1H3,(H,30,31)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM369415
PNG
(4-(4-((5-Fluoro-2-(5,6,7,8-tetrahydronaphthalen-2-...)
Show SMILES OC(=O)CCCc1ccc(OCc2cc(F)ccc2-c2ccc3CCCCc3c2)cc1
Show InChI InChI=1S/C27H27FO3/c28-24-12-15-26(22-11-10-20-5-1-2-6-21(20)16-22)23(17-24)18-31-25-13-8-19(9-14-25)4-3-7-27(29)30/h8-17H,1-7,18H2,(H,29,30)
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Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120L receptor using β-galactos...


US Patent US10227360 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%