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Patent code US10233156

Compile Data Set for Download or QSAR
Found 57 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369707
PNG
(US10233156, Example I-247)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2ccc(OC3CC3)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C22H30FN3O4/c1-13(24-14(2)27)12-28-15-4-6-17(7-5-15)30-22-25-18-10-11-19(29-16-8-9-16)20(23)21(18)26(22)3/h10-11,13,15-17H,4-9,12H2,1-3H3,(H,24,27)/t13-,15-,17-/s2
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n/an/a 3.90n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369665
PNG
(US10233156, Example I-205)
Show SMILES CC(=O)N[C@@H](CF)CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(OCC(F)F)c(Cl)c2n1C
Show InChI InChI=1/C21H26ClF4N3O4/c1-11(30)27-12(8-23)9-31-13-3-5-14(6-4-13)33-21-28-19-15(24)7-16(32-10-17(25)26)18(22)20(19)29(21)2/h7,12-14,17H,3-6,8-10H2,1-2H3,(H,27,30)/t12-,13-,14-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369662
PNG
(US10233156, Example I-201)
Show SMILES CC(=O)N[C@@H](CF)CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(OC3CC3)cc2n1C
Show InChI InChI=1/C22H29F2N3O4/c1-13(28)25-14(11-23)12-29-15-3-5-17(6-4-15)31-22-26-21-19(24)9-18(30-16-7-8-16)10-20(21)27(22)2/h9-10,14-17H,3-8,11-12H2,1-2H3,(H,25,28)/t14-,15-,17-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369655
PNG
(US10233156, Example I-194)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(OC3CCC3)cc2n1C)NC(C)=O
Show InChI InChI=1/C23H32FN3O4/c1-14(25-15(2)28)13-29-16-7-9-18(10-8-16)31-23-26-22-20(24)11-19(12-21(22)27(23)3)30-17-5-4-6-17/h11-12,14,16-18H,4-10,13H2,1-3H3,(H,25,28)/t14-,16-,18-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369669
PNG
(US10233156, Example I-209)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)c(F)c(OCC(F)F)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C21H26F5N3O4/c1-10(27-11(2)30)8-31-12-4-6-13(7-5-12)33-21-28-18-15(24)16(25)20(32-9-14(22)23)17(26)19(18)29(21)3/h10,12-14H,4-9H2,1-3H3,(H,27,30)/t10-,12-,13-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369659
PNG
(US10233156, Example I-198)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2ccc(OC3CC3)c(F)c2n1C)NC(N)=O
Show InChI InChI=1/C21H29FN4O4/c1-12(24-20(23)27)11-28-13-3-5-15(6-4-13)30-21-25-16-9-10-17(29-14-7-8-14)18(22)19(16)26(21)2/h9-10,12-15H,3-8,11H2,1-2H3,(H3,23,24,27)/t12-,13-,15-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369667
PNG
(US10233156, Example I-207)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2cc(F)c(OC3CC3)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C22H29F2N3O4/c1-12(25-13(2)28)11-29-14-4-6-16(7-5-14)31-22-26-18-10-17(23)21(30-15-8-9-15)19(24)20(18)27(22)3/h10,12,14-16H,4-9,11H2,1-3H3,(H,25,28)/t12-,14-,16-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369703
PNG
(US10233156, Example I-243)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(OC3CC3)cc2n1C)NC(N)=O
Show InChI InChI=1/C21H29FN4O4/c1-12(24-20(23)27)11-28-13-3-5-15(6-4-13)30-21-25-19-17(22)9-16(29-14-7-8-14)10-18(19)26(21)2/h9-10,12-15H,3-8,11H2,1-2H3,(H3,23,24,27)/t12-,13-,15-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369686
PNG
(US10233156, Example I-226)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(cc(OC3CCC3)c(F)c2n1C)C#N)NC(C)=O
Show InChI InChI=1/C24H31FN4O4/c1-14(27-15(2)30)13-31-17-7-9-19(10-8-17)33-24-28-22-16(12-26)11-20(32-18-5-4-6-18)21(25)23(22)29(24)3/h11,14,17-19H,4-10,13H2,1-3H3,(H,27,30)/t14-,17-,19-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369661
PNG
(US10233156, Example I-200)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(Cl)cc(OC3CC3)cc2n1C)NC(C)=O
Show InChI InChI=1/C22H30ClN3O4/c1-13(24-14(2)27)12-28-15-4-6-17(7-5-15)30-22-25-21-19(23)10-18(29-16-8-9-16)11-20(21)26(22)3/h10-11,13,15-17H,4-9,12H2,1-3H3,(H,24,27)/t13-,15-,17-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369709
PNG
(US10233156, Example I-249)
Show SMILES C[C@@H](CC[C@H]1OC[C@@H](CO1)Oc1nc2c(F)cc(OC3CC3)cc2n1C)NC(C)=O
Show InChI InChI=1/C21H28FN3O5/c1-12(23-13(2)26)4-7-19-27-10-16(11-28-19)30-21-24-20-17(22)8-15(29-14-5-6-14)9-18(20)25(21)3/h8-9,12,14,16,19H,4-7,10-11H2,1-3H3,(H,23,26)/t12-,16-,19-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369670
PNG
(US10233156, Example I-210)
Show SMILES CC(=O)N[C@@H](CF)CO[C@H]1CC[C@@H](CC1)Oc1nc2cnc(OC3CC3)c(F)c2n1C
Show InChI InChI=1/C21H28F2N4O4/c1-12(28)25-13(9-22)11-29-14-3-5-16(6-4-14)31-21-26-17-10-24-20(30-15-7-8-15)18(23)19(17)27(21)2/h10,13-16H,3-9,11H2,1-2H3,(H,25,28)/t13-,14-,16-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM307498
PNG
(US10150728, Example I-741 | US10233156, Example I-...)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(OCC(F)F)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C21H27F4N3O4/c1-11(26-12(2)29)9-30-13-4-6-14(7-5-13)32-21-27-19-15(22)8-16(31-10-17(23)24)18(25)20(19)28(21)3/h8,11,13-14,17H,4-7,9-10H2,1-3H3,(H,26,29)/t11-,13-,14-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369673
PNG
(US10233156, Example I-213)
Show SMILES Cn1c(O[C@H]2CC[C@@H](CC2)OC[C@H](CF)NC(N)=O)nc2c(F)cc(OC3CC3)cc12
Show InChI InChI=1/C21H28F2N4O4/c1-27-18-9-16(30-14-6-7-14)8-17(23)19(18)26-21(27)31-15-4-2-13(3-5-15)29-11-12(10-22)25-20(24)28/h8-9,12-15H,2-7,10-11H2,1H3,(H3,24,25,28)/t12-,13-,15-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369681
PNG
(US10233156, Example I-221)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2ccc(OC3CC3)cc2n1C)NC(C)=O
Show InChI InChI=1/C22H31N3O4/c1-14(23-15(2)26)13-27-16-4-6-18(7-5-16)29-22-24-20-11-10-19(28-17-8-9-17)12-21(20)25(22)3/h10-12,14,16-18H,4-9,13H2,1-3H3,(H,23,26)/t14-,16-,18-/s2
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US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369701
PNG
(US10233156, Example I-241)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2cc(F)c(OC3CC3)c(F)c2n1C)NC(N)=O
Show InChI InChI=1/C21H28F2N4O4/c1-11(25-20(24)28)10-29-12-3-5-14(6-4-12)31-21-26-16-9-15(22)19(30-13-7-8-13)17(23)18(16)27(21)2/h9,11-14H,3-8,10H2,1-2H3,(H3,24,25,28)/t11-,12-,14-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369696
PNG
(US10233156, Example I-236)
Show SMILES C[C@@H](CCC1OC[C@@H](CO1)Oc1nc2c(F)cc(OCC(F)F)c(F)c2n1C)NC(N)=O
Show InChI InChI=1/C19H24F4N4O5/c1-9(25-18(24)28)3-4-14-30-6-10(7-31-14)32-19-26-16-11(20)5-12(29-8-13(21)22)15(23)17(16)27(19)2/h5,9-10,13-14H,3-4,6-8H2,1-2H3,(H3,24,25,28)/t9-,10-,14?/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369691
PNG
(US10233156, Example I-231)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(OC(F)F)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C20H25F4N3O4/c1-10(25-11(2)28)9-29-12-4-6-13(7-5-12)30-20-26-17-14(21)8-15(31-19(23)24)16(22)18(17)27(20)3/h8,10,12-13,19H,4-7,9H2,1-3H3,(H,25,28)/t10-,12-,13-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369657
PNG
(US10233156, Example I-196)
Show SMILES C[C@@H](CC[C@H]1OC[C@@H](C[C@@H]1F)Oc1nc2c(F)cc(OCC(F)F)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C21H26F5N3O4/c1-10(27-11(2)30)4-5-15-13(22)6-12(8-31-15)33-21-28-19-14(23)7-16(32-9-17(24)25)18(26)20(19)29(21)3/h7,10,12-13,15,17H,4-6,8-9H2,1-3H3,(H,27,30)/t10-,12+,13-,15+/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369692
PNG
(US10233156, Example I-232)
Show SMILES Cn1c(O[C@H]2CC[C@@H](CC2)OC[C@H](CF)NC(N)=O)nc2c(F)cc(OCC(F)F)c(F)c12
Show InChI InChI=1/C20H25F5N4O4/c1-29-18-16(25)14(32-9-15(23)24)6-13(22)17(18)28-20(29)33-12-4-2-11(3-5-12)31-8-10(7-21)27-19(26)30/h6,10-12,15H,2-5,7-9H2,1H3,(H3,26,27,30)/t10-,11-,12-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369697
PNG
(US10233156, Example I-237)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2cnc(OC3CC3)c(F)c2n1C)NC(N)=O
Show InChI InChI=1/C20H28FN5O4/c1-11(24-19(22)27)10-28-12-3-5-14(6-4-12)30-20-25-15-9-23-18(29-13-7-8-13)16(21)17(15)26(20)2/h9,11-14H,3-8,10H2,1-2H3,(H3,22,24,27)/t11-,12-,14-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369674
PNG
(US10233156, Example I-214)
Show SMILES C[C@H](NC(C)=O)C(F)(F)C[C@H]1CC[C@@H](CO1)Oc1nc2c(F)cc(OCC(F)F)c(F)c2n1C
Show InChI InChI=1/C21H25F6N3O4/c1-10(28-11(2)31)21(26,27)7-12-4-5-13(8-32-12)34-20-29-18-14(22)6-15(33-9-16(23)24)17(25)19(18)30(20)3/h6,10,12-13,16H,4-5,7-9H2,1-3H3,(H,28,31)/t10-,12+,13-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369679
PNG
(US10233156, Example I-219)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(OC3COC3)c(Cl)c2n1C)NC(C)=O
Show InChI InChI=1/C22H29ClFN3O5/c1-12(25-13(2)28)9-30-14-4-6-15(7-5-14)32-22-26-20-17(24)8-18(31-16-10-29-11-16)19(23)21(20)27(22)3/h8,12,14-16H,4-7,9-11H2,1-3H3,(H,25,28)/t12-,14-,15-/s2
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US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369666
PNG
(US10233156, Example I-206)
Show SMILES CC(=O)N[C@@H](CF)CO[C@H]1CC[C@@H](CC1)Oc1nc2c(cc(OC3CC3)c(F)c2n1C)C#N
Show InChI InChI=1/C23H28F2N4O4/c1-13(30)27-15(10-24)12-31-16-3-5-18(6-4-16)33-23-28-21-14(11-26)9-19(32-17-7-8-17)20(25)22(21)29(23)2/h9,15-18H,3-8,10,12H2,1-2H3,(H,27,30)/t15-,16-,18-/s2
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Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369694
PNG
(US10233156, Example I-234)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2ccc(OC3CC3)nc2n1C)NC(C)=O
Show InChI InChI=1/C21H30N4O4/c1-13(22-14(2)26)12-27-15-4-6-17(7-5-15)29-21-23-18-10-11-19(28-16-8-9-16)24-20(18)25(21)3/h10-11,13,15-17H,4-9,12H2,1-3H3,(H,22,26)/t13-,15-,17-/s2
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US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369688
PNG
(US10233156, Example I-228)
Show SMILES C[C@@H](CC[C@H]1OC[C@@H](CC1(F)F)Oc1nc2c(F)cc(OCC(F)F)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C21H25F6N3O4/c1-10(28-11(2)31)4-5-15-21(26,27)7-12(8-33-15)34-20-29-18-13(22)6-14(32-9-16(23)24)17(25)19(18)30(20)3/h6,10,12,15-16H,4-5,7-9H2,1-3H3,(H,28,31)/t10-,12+,15+/s2
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US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369658
PNG
(US10233156, Example I-197)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2ccc(OC3CC3)cc2n1C)NC(N)=O
Show InChI InChI=1/C21H30N4O4/c1-13(23-20(22)26)12-27-14-3-5-16(6-4-14)29-21-24-18-10-9-17(28-15-7-8-15)11-19(18)25(21)2/h9-11,13-16H,3-8,12H2,1-2H3,(H3,22,23,26)/t13-,14-,16-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369663
PNG
(US10233156, Example I-202)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2ccc(OC3(C)CC3)cc2n1C)NC(C)=O
Show InChI InChI=1/C23H33N3O4/c1-15(24-16(2)27)14-28-17-5-7-18(8-6-17)29-22-25-20-10-9-19(13-21(20)26(22)4)30-23(3)11-12-23/h9-10,13,15,17-18H,5-8,11-12,14H2,1-4H3,(H,24,27)/t15-,17-,18-/s2
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Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369675
PNG
(US10233156, Example I-215)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2cc(F)c(F)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C19H24F3N3O3/c1-10(23-11(2)26)9-27-12-4-6-13(7-5-12)28-19-24-15-8-14(20)16(21)17(22)18(15)25(19)3/h8,10,12-13H,4-7,9H2,1-3H3,(H,23,26)/t10-,12-,13-/s2
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SHIONOGI & CO., LTD.

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Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369682
PNG
(US10233156, Example I-222)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(Cl)cc(OC3CC3)cc2n1C)NC(N)=O
Show InChI InChI=1/C21H29ClN4O4/c1-12(24-20(23)27)11-28-13-3-5-15(6-4-13)30-21-25-19-17(22)9-16(29-14-7-8-14)10-18(19)26(21)2/h9-10,12-15H,3-8,11H2,1-2H3,(H3,23,24,27)/t12-,13-,15-/s2
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Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369710
PNG
(US10233156, Example I-250)
Show SMILES C[C@H](NC(C)=O)\C=C(/F)[C@@H]1CC[C@H](CO1)Oc1nc2c(F)cc(OCC(F)F)c(F)c2n1C
Show InChI InChI=1/C21H24F5N3O4/c1-10(27-11(2)30)6-13(22)15-5-4-12(8-31-15)33-21-28-19-14(23)7-16(32-9-17(24)25)18(26)20(19)29(21)3/h6-7,10,12,15,17H,4-5,8-9H2,1-3H3,(H,27,30)/b13-6-/t10-,12+,15-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369704
PNG
(US10233156, Example I-244)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(OCC(C)(C)C#N)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C24H32F2N4O4/c1-14(28-15(2)31)11-32-16-6-8-17(9-7-16)34-23-29-21-18(25)10-19(20(26)22(21)30(23)5)33-13-24(3,4)12-27/h10,14,16-17H,6-9,11,13H2,1-5H3,(H,28,31)/t14-,16-,17-/s2
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SHIONOGI & CO., LTD.

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Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369699
PNG
(US10233156, Example I-239)
Show SMILES COC(=O)N[C@@H](CF)CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(OCC(F)F)c(F)c2n1C
Show InChI InChI=1/C21H26F5N3O5/c1-29-19-17(26)15(33-10-16(24)25)7-14(23)18(19)28-20(29)34-13-5-3-12(4-6-13)32-9-11(8-22)27-21(30)31-2/h7,11-13,16H,3-6,8-10H2,1-2H3,(H,27,30)/t11-,12-,13-/s2
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SHIONOGI & CO., LTD.

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Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369693
PNG
(US10233156, Example I-233)
Show SMILES Cn1c(O[C@H]2CC[C@@H](CC2)OC[C@H](CF)NC(=O)C2CC2)nc2c(F)cc(OCC(F)F)c(F)c12
Show InChI InChI=1/C23H28F5N3O4/c1-31-21-19(28)17(34-11-18(26)27)8-16(25)20(21)30-23(31)35-15-6-4-14(5-7-15)33-10-13(9-24)29-22(32)12-2-3-12/h8,12-15,18H,2-7,9-11H2,1H3,(H,29,32)/t13-,14-,15-/s2
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SHIONOGI & CO., LTD.

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Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369685
PNG
(US10233156, Example I-225)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(cc(OC3CC3)cc2n1C)C#N)NC(C)=O
Show InChI InChI=1/C23H30N4O4/c1-14(25-15(2)28)13-29-17-4-6-19(7-5-17)31-23-26-22-16(12-24)10-20(30-18-8-9-18)11-21(22)27(23)3/h10-11,14,17-19H,4-9,13H2,1-3H3,(H,25,28)/t14-,17-,19-/s2
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Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369656
PNG
(US10233156, Example I-195)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(OCC3(F)COC3)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C23H30F3N3O5/c1-13(27-14(2)30)9-32-15-4-6-16(7-5-15)34-22-28-20-17(24)8-18(19(25)21(20)29(22)3)33-12-23(26)10-31-11-23/h8,13,15-16H,4-7,9-12H2,1-3H3,(H,27,30)/t13-,15-,16-/s2
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Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369695
PNG
(US10233156, Example I-235)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)c(F)c(F)c(F)c2n1C)NC(N)=O
Show InChI InChI=1/C18H22F4N4O3/c1-8(24-17(23)27)7-28-9-3-5-10(6-4-9)29-18-25-15-13(21)11(19)12(20)14(22)16(15)26(18)2/h8-10H,3-7H2,1-2H3,(H3,23,24,27)/t8-,9-,10-/s2
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Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369687
PNG
(US10233156, Example I-227)
Show SMILES Cn1c(O[C@H]2CC[C@@H](CC2)OC[C@H](CF)NC(=O)CC#N)nc2c(F)cc(OCC(F)F)c(F)c12
Show InChI InChI=1/C22H25F5N4O4/c1-31-21-19(27)16(34-11-17(25)26)8-15(24)20(21)30-22(31)35-14-4-2-13(3-5-14)33-10-12(9-23)29-18(32)6-7-28/h8,12-14,17H,2-6,9-11H2,1H3,(H,29,32)/t12-,13-,14-/s2
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Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369700
PNG
(US10233156, Example I-240)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2ccc(OC3CC3)nc2n1C)NC(N)=O
Show InChI InChI=1/C20H29N5O4/c1-12(22-19(21)26)11-27-13-3-5-15(6-4-13)29-20-23-16-9-10-17(28-14-7-8-14)24-18(16)25(20)2/h9-10,12-15H,3-8,11H2,1-2H3,(H3,21,22,26)/t12-,13-,15-/s2
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Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369705
PNG
(US10233156, Example I-245)
Show SMILES Cn1c(O[C@H]2CC[C@@H](CC2)OC[C@H](CF)NC(=O)CO)nc2c(F)cc(OCC(F)F)c(F)c12
Show InChI InChI=1/C21H26F5N3O5/c1-29-20-18(26)15(33-10-16(24)25)6-14(23)19(20)28-21(29)34-13-4-2-12(3-5-13)32-9-11(7-22)27-17(31)8-30/h6,11-13,16,30H,2-5,7-10H2,1H3,(H,27,31)/t11-,12-,13-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369672
PNG
(US10233156, Example I-212)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2cc(F)c(OC3CC3)cc2n1C)NC(C)=O
Show InChI InChI=1/C22H30FN3O4/c1-13(24-14(2)27)12-28-15-4-6-17(7-5-15)30-22-25-19-10-18(23)21(29-16-8-9-16)11-20(19)26(22)3/h10-11,13,15-17H,4-9,12H2,1-3H3,(H,24,27)/t13-,15-,17-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369676
PNG
(US10233156, Example I-216)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(OC3CC4(COC4)C3)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C25H33F2N3O5/c1-14(28-15(2)31)11-33-16-4-6-17(7-5-16)35-24-29-22-19(26)8-20(21(27)23(22)30(24)3)34-18-9-25(10-18)12-32-13-25/h8,14,16-18H,4-7,9-13H2,1-3H3,(H,28,31)/t14-,16-,17-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369677
PNG
(US10233156, Example I-217)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2cc(F)c(Cl)cc2n1C)NC(C)=O
Show InChI InChI=1/C19H25ClFN3O3/c1-11(22-12(2)25)10-26-13-4-6-14(7-5-13)27-19-23-17-9-16(21)15(20)8-18(17)24(19)3/h8-9,11,13-14H,4-7,10H2,1-3H3,(H,22,25)/t11-,13-,14-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369706
PNG
(US10233156, Example I-246)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(O[C@@H]3C[C@H](O)C3)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C23H31F2N3O5/c1-12(26-13(2)29)11-31-15-4-6-16(7-5-15)33-23-27-21-18(24)10-19(20(25)22(21)28(23)3)32-17-8-14(30)9-17/h10,12,14-17,30H,4-9,11H2,1-3H3,(H,26,29)/t12-,14-,15-,16-,17+/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369698
PNG
(US10233156, Example I-238)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2cc(F)c(F)cc2n1C)NC(C)=O
Show InChI InChI=1/C19H25F2N3O3/c1-11(22-12(2)25)10-26-13-4-6-14(7-5-13)27-19-23-17-8-15(20)16(21)9-18(17)24(19)3/h8-9,11,13-14H,4-7,10H2,1-3H3,(H,22,25)/t11-,13-,14-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369683
PNG
(US10233156, Example I-223)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(O[C@H]3C[C@H](O)C3)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C23H31F2N3O5/c1-12(26-13(2)29)11-31-15-4-6-16(7-5-15)33-23-27-21-18(24)10-19(20(25)22(21)28(23)3)32-17-8-14(30)9-17/h10,12,14-17,30H,4-9,11H2,1-3H3,(H,26,29)/t12-,14-,15-,16-,17-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369690
PNG
(US10233156, Example I-230)
Show SMILES C[C@@H](CC(F)(F)[C@@H]1CC[C@H](CO1)Oc1nc2c(F)cc(OCC(F)F)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C21H25F6N3O4/c1-10(28-11(2)31)7-21(26,27)15-5-4-12(8-33-15)34-20-29-18-13(22)6-14(32-9-16(23)24)17(25)19(18)30(20)3/h6,10,12,15-16H,4-5,7-9H2,1-3H3,(H,28,31)/t10-,12+,15-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369711
PNG
(US10233156, Example I-251)
Show SMILES C[C@@H](CO[C@@H]1CC[C@H](Cc2nc3c(F)cc(OCC(F)F)c(F)c3n2C)CC1)NC(C)=O
Show InChI InChI=1/C22H29F4N3O3/c1-12(27-13(2)30)10-31-15-6-4-14(5-7-15)8-19-28-21-16(23)9-17(32-11-18(24)25)20(26)22(21)29(19)3/h9,12,14-15,18H,4-8,10-11H2,1-3H3,(H,27,30)/t12-,14-,15+/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369664
PNG
(US10233156, Example I-203)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(OC3(C)COC3)c(F)c2n1C)NC(C)=O
Show InChI InChI=1/C23H31F2N3O5/c1-13(26-14(2)29)10-31-15-5-7-16(8-6-15)32-22-27-20-17(24)9-18(19(25)21(20)28(22)4)33-23(3)11-30-12-23/h9,13,15-16H,5-8,10-12H2,1-4H3,(H,26,29)/t13-,15-,16-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369671
PNG
(US10233156, Example I-211)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2cc(Cl)c(F)cc2n1C)NC(C)=O
Show InChI InChI=1/C19H25ClFN3O3/c1-11(22-12(2)25)10-26-13-4-6-14(7-5-13)27-19-23-17-8-15(20)16(21)9-18(17)24(19)3/h8-9,11,13-14H,4-7,10H2,1-3H3,(H,22,25)/t11-,13-,14-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369702
PNG
(US10233156, Example I-242)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(OCC(F)F)c(F)c2n1C)NS(N)(=O)=O
Show InChI InChI=1/C19H26F4N4O5S/c1-10(26-33(24,28)29)8-30-11-3-5-12(6-4-11)32-19-25-17-13(20)7-14(31-9-15(21)22)16(23)18(17)27(19)2/h7,10-12,15,26H,3-6,8-9H2,1-2H3,(H2,24,28,29)/t10-,11-,12-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369678
PNG
(US10233156, Example I-218)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2cc(F)c(OC3CC3)cc2n1C)NC(N)=O
Show InChI InChI=1/C21H29FN4O4/c1-12(24-20(23)27)11-28-13-3-5-15(6-4-13)30-21-25-17-9-16(22)19(29-14-7-8-14)10-18(17)26(21)2/h9-10,12-15H,3-8,11H2,1-2H3,(H3,23,24,27)/t12-,13-,15-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369684
PNG
(US10233156, Example I-224)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2cnc(OC3CC3)cc2n1C)NC(C)=O
Show InChI InChI=1/C21H30N4O4/c1-13(23-14(2)26)12-27-15-4-6-17(7-5-15)29-21-24-18-11-22-20(28-16-8-9-16)10-19(18)25(21)3/h10-11,13,15-17H,4-9,12H2,1-3H3,(H,23,26)/t13-,15-,17-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369708
PNG
(US10233156, Example I-248)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2c(F)cc(OCC(F)F)c(Cl)c2n1C)NS(N)(=O)=O
Show InChI InChI=1/C19H26ClF3N4O5S/c1-10(26-33(24,28)29)8-30-11-3-5-12(6-4-11)32-19-25-17-13(21)7-14(31-9-15(22)23)16(20)18(17)27(19)2/h7,10-12,15,26H,3-6,8-9H2,1-2H3,(H2,24,28,29)/t10-,11-,12-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369680
PNG
(US10233156, Example I-220)
Show SMILES C[C@@H](NC(C)=O)C(F)(F)C[C@H]1CC[C@@H](CO1)Oc1nc2c(F)cc(OCC(F)F)c(F)c2n1C
Show InChI InChI=1/C21H25F6N3O4/c1-10(28-11(2)31)21(26,27)7-12-4-5-13(8-32-12)34-20-29-18-14(22)6-15(33-9-16(23)24)17(25)19(18)30(20)3/h6,10,12-13,16H,4-5,7-9H2,1-3H3,(H,28,31)/t10-,12-,13+/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369689
PNG
(US10233156, Example I-229)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2cnc(OC3CC3)cc2n1C)NC(N)=O
Show InChI InChI=1/C20H29N5O4/c1-12(23-19(21)26)11-27-13-3-5-15(6-4-13)29-20-24-16-10-22-18(28-14-7-8-14)9-17(16)25(20)2/h9-10,12-15H,3-8,11H2,1-2H3,(H3,21,23,26)/t12-,13-,15-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM369660
PNG
(US10233156, Example I-199)
Show SMILES C[C@@H](CO[C@H]1CC[C@@H](CC1)Oc1nc2ncc(OC3CC3)cc2n1C)NC(C)=O
Show InChI InChI=1/C21H30N4O4/c1-13(23-14(2)26)12-27-15-4-6-17(7-5-15)29-21-24-20-19(25(21)3)10-18(11-22-20)28-16-8-9-16/h10-11,13,15-17H,4-9,12H2,1-3H3,(H,23,26)/t13-,15-,17-/s2
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...


US Patent US10233156 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%