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Patent code US10233182

Compile Data Set for Download or QSAR

Found 245 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Autotaxin


(Homo sapiens (Human))
BDBM369924
PNG
((R)-2-Fluoro-N-(3-methyl-1-(3-methyl-2,4-dioxo-1-(...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc2occc2c1
Show InChI InChI=1/C29H28F4N4O5/c1-16(2)23(34-24(38)20-15-18(29(31,32)33)4-6-21(20)30)25(39)36-11-9-28(10-12-36)26(40)35(3)27(41)37(28)19-5-7-22-17(14-19)8-13-42-22/h4-8,13-16,23H,9-12H2,1-3H3,(H,34,38)/t23-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369926
PNG
((R)-5-Ethyl-2-fluoro-N-(3-methyl-1-(3-methyl-2,4-d...)
Show SMILES CCc1ccc(F)c(c1)C(=O)N[C@H](C(C)C)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1/C29H32FN5O6/c1-5-17-6-8-20(30)19(14-17)24(36)32-23(16(2)3)25(37)34-12-10-29(11-13-34)26(38)33(4)28(40)35(29)18-7-9-21-22(15-18)41-27(39)31-21/h6-9,14-16,23H,5,10-13H2,1-4H3,(H,31,39)(H,32,36)/t23-/s2
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US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369927
PNG
((R)—N-(1-(1-(1H-Benzo[d][1,2,3]triazol-5-yl)-...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc2[nH]nnc2c1
Show InChI InChI=1/C27H27F4N7O4/c1-14(2)21(32-22(39)17-12-15(27(29,30)31)4-6-18(17)28)23(40)37-10-8-26(9-11-37)24(41)36(3)25(42)38(26)16-5-7-19-20(13-16)34-35-33-19/h4-7,12-14,21H,8-11H2,1-3H3,(H,32,39)(H,33,34,35)/t21-/s2
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US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369943
PNG
((R)—N-(1-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(C)ccc1F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc2[nH]ncc2c1
Show InChI InChI=1/C28H31FN6O4/c1-16(2)23(31-24(36)20-13-17(3)5-7-21(20)29)25(37)34-11-9-28(10-12-34)26(38)33(4)27(39)35(28)19-6-8-22-18(14-19)15-30-32-22/h5-8,13-16,23H,9-12H2,1-4H3,(H,30,32)(H,31,36)/t23-/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369946
PNG
(US10233182, Example 59)
Show SMILES CC(C)[C@@H](NC(=O)c1cccc(c1)C(F)(F)F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc2[nH]ncc2c1
Show InChI InChI=1/C28H29F3N6O4/c1-16(2)22(33-23(38)17-5-4-6-19(13-17)28(29,30)31)24(39)36-11-9-27(10-12-36)25(40)35(3)26(41)37(27)20-7-8-21-18(14-20)15-32-34-21/h4-8,13-16,22H,9-12H2,1-3H3,(H,32,34)(H,33,38)/t22-/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369951
PNG
((R)-2-Fluoro-N-(1-(1-(4-(2-hydroxyethoxy)phenyl)-3...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc(OCCO)cc1
Show InChI InChI=1/C29H32F4N4O6/c1-17(2)23(34-24(39)21-16-18(29(31,32)33)4-9-22(21)30)25(40)36-12-10-28(11-13-36)26(41)35(3)27(42)37(28)19-5-7-20(8-6-19)43-15-14-38/h4-9,16-17,23,38H,10-15H2,1-3H3,(H,34,39)/t23-/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369962
PNG
((R)—N-(1-(1-(3-Cyanobenzyl)-3-methyl-2,4-diox...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(Cc1cccc(c1)C#N)C(=O)N(C)C2=O
Show InChI InChI=1/C29H29F4N5O4/c1-17(2)23(35-24(39)21-14-20(29(31,32)33)7-8-22(21)30)25(40)37-11-9-28(10-12-37)26(41)36(3)27(42)38(28)16-19-6-4-5-18(13-19)15-34/h4-8,13-14,17,23H,9-12,16H2,1-3H3,(H,35,39)/t23-/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369963
PNG
((R)—N-(1-(1-(3-Chlorobenzyl)-3-methyl-2,4-dio...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(Cc1cccc(Cl)c1)C(=O)N(C)C2=O
Show InChI InChI=1/C28H29ClF4N4O4/c1-16(2)22(34-23(38)20-14-18(28(31,32)33)7-8-21(20)30)24(39)36-11-9-27(10-12-36)25(40)35(3)26(41)37(27)15-17-5-4-6-19(29)13-17/h4-8,13-14,16,22H,9-12,15H2,1-3H3,(H,34,38)/t22-/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369966
PNG
((R)-2-Fluoro-N-(1-(1-(2-fluoro-4-methoxybenzyl)-3-...)
Show SMILES COc1ccc(CN2C(=O)N(C)C(=O)C22CCN(CC2)C(=O)[C@H](NC(=O)c2cc(ccc2F)C(F)(F)F)C(C)C)c(F)c1
Show InChI InChI=1/C29H31F5N4O5/c1-16(2)23(35-24(39)20-13-18(29(32,33)34)6-8-21(20)30)25(40)37-11-9-28(10-12-37)26(41)36(3)27(42)38(28)15-17-5-7-19(43-4)14-22(17)31/h5-8,13-14,16,23H,9-12,15H2,1-4H3,(H,35,39)/t23-/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369967
PNG
((R)—N-(1-Cyclopropyl-2-(3-methyl-2,4-dioxo-1-...)
Show SMILES CN1C(=O)N(Cc2ccc3nccnc3c2)C2(CCN(CC2)C(=O)[C@H](NC(=O)c2cc(ccc2F)C(F)(F)F)C2CC2)C1=O
Show InChI InChI=1/C30H28F4N6O4/c1-38-27(43)29(40(28(38)44)16-17-2-7-22-23(14-17)36-11-10-35-22)8-12-39(13-9-29)26(42)24(18-3-4-18)37-25(41)20-15-19(30(32,33)34)5-6-21(20)31/h2,5-7,10-11,14-15,18,24H,3-4,8-9,12-13,16H2,1H3,(H,37,41)/t24-/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369968
PNG
((R)—N-(1-Cyclobutyl-2-(3-methyl-2,4-dioxo-1-(...)
Show SMILES CN1C(=O)N(Cc2ccc3nccnc3c2)C2(CCN(CC2)C(=O)[C@H](NC(=O)c2cc(ccc2F)C(F)(F)F)C2CCC2)C1=O
Show InChI InChI=1/C31H30F4N6O4/c1-39-28(44)30(41(29(39)45)17-18-5-8-23-24(15-18)37-12-11-36-23)9-13-40(14-10-30)27(43)25(19-3-2-4-19)38-26(42)21-16-20(31(33,34)35)6-7-22(21)32/h5-8,11-12,15-16,19,25H,2-4,9-10,13-14,17H2,1H3,(H,38,42)/t25-/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369976
PNG
(5-Ethyl-2-fluoro-N-((2R,3S)-3-methoxy-1-(3-methyl-...)
Show SMILES CCc1ccc(F)c(c1)C(=O)N[C@H]([C@H](C)OC)C(=O)N1CCC2(CC1)N(CN(C)C2=O)c1ccccc1
Show InChI InChI=1/C28H35FN4O4/c1-5-20-11-12-23(29)22(17-20)25(34)30-24(19(2)37-4)26(35)32-15-13-28(14-16-32)27(36)31(3)18-33(28)21-9-7-6-8-10-21/h6-12,17,19,24H,5,13-16,18H2,1-4H3,(H,30,34)/t19-,24+/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369984
PNG
((R)-3-Cyclopropyl-N-(3-methyl-1-(3-methyl-4-oxo-1-...)
Show SMILES CC(C)[C@@H](NC(=O)c1cccc(c1)C1CC1)C(=O)N1CCC2(CC1)N(CN(C)C2=O)c1ccccc1
Show InChI InChI=1/C29H36N4O3/c1-20(2)25(30-26(34)23-9-7-8-22(18-23)21-12-13-21)27(35)32-16-14-29(15-17-32)28(36)31(3)19-33(29)24-10-5-4-6-11-24/h4-11,18,20-21,25H,12-17,19H2,1-3H3,(H,30,34)/t25-/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369989
PNG
((R)-4-(8-(2-(2-Fluoro-5-(trifluoromethyl)benzamido...)
Show SMILES COc1cc(ccc1C(O)=O)N1CN(C)C(=O)C11CCN(CC1)C(=O)[C@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(C)C
Show InChI InChI=1/C29H32F4N4O6/c1-16(2)23(34-24(38)20-13-17(29(31,32)33)5-8-21(20)30)25(39)36-11-9-28(10-12-36)27(42)35(3)15-37(28)18-6-7-19(26(40)41)22(14-18)43-4/h5-8,13-14,16,23H,9-12,15H2,1-4H3,(H,34,38)(H,40,41)/t23-/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370010
PNG
((R)-2-Fluoro-3-methyl-N-(3-methyl-1-(3-(3-(methyls...)
Show SMILES CC(C)[C@@H](NC(=O)c1cccc(C)c1F)C(=O)N1CCC2(CC1)N(CN(CCCS(C)(=O)=O)C2=O)c1ccccc1
Show InChI InChI=1/C30H39FN4O5S/c1-21(2)26(32-27(36)24-13-8-10-22(3)25(24)31)28(37)33-17-14-30(15-18-33)29(38)34(16-9-19-41(4,39)40)20-35(30)23-11-6-5-7-12-23/h5-8,10-13,21,26H,9,14-20H2,1-4H3,(H,32,36)/t26-/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370024
PNG
((R)—N-(1-(1-(3-Bromophenyl)-3-methyl-4-oxo-1,...)
Show SMILES CC(C)[C@@H](NC(=O)c1cccc(C)c1)C(=O)N1CCC2(CC1)N(CN(C)C2=O)c1cccc(Br)c1
Show InChI InChI=1/C27H33BrN4O3/c1-18(2)23(29-24(33)20-8-5-7-19(3)15-20)25(34)31-13-11-27(12-14-31)26(35)30(4)17-32(27)22-10-6-9-21(28)16-22/h5-10,15-16,18,23H,11-14,17H2,1-4H3,(H,29,33)/t23-/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370027
PNG
((R)—N-(1-(1-(3-Methoxyphenyl)-3-methyl-4-oxo-...)
Show SMILES COc1cccc(c1)N1CN(C)C(=O)C11CCN(CC1)C(=O)[C@H](NC(=O)c1cccc(C)c1)C(C)C
Show InChI InChI=1/C28H36N4O4/c1-19(2)24(29-25(33)21-9-6-8-20(3)16-21)26(34)31-14-12-28(13-15-31)27(35)30(4)18-32(28)22-10-7-11-23(17-22)36-5/h6-11,16-17,19,24H,12-15,18H2,1-5H3,(H,29,33)/t24-/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370035
PNG
((R)-2-Fluoro-N-(1-(1-(imidazo[1,2-a]pyridin-6-yl)-...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(CN(C)C2=O)c1ccc2nccn2c1
Show InChI InChI=1/C28H30F4N6O3/c1-17(2)23(34-24(39)20-14-18(28(30,31)32)4-6-21(20)29)25(40)36-11-8-27(9-12-36)26(41)35(3)16-38(27)19-5-7-22-33-10-13-37(22)15-19/h4-7,10,13-15,17,23H,8-9,11-12,16H2,1-3H3,(H,34,39)/t23-/s2
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Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370038
PNG
(2-Fluoro-N-((2R)-1-(1-(4-methoxyphenyl)-2,3-dimeth...)
Show SMILES COc1ccc(cc1)N1C(C)N(C)C(=O)C11CCN(CC1)C(=O)[C@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(C)C
Show InChI InChI=1/C29H34F4N4O4/c1-17(2)24(34-25(38)22-16-19(29(31,32)33)6-11-23(22)30)26(39)36-14-12-28(13-15-36)27(40)35(4)18(3)37(28)20-7-9-21(41-5)10-8-20/h6-11,16-18,24H,12-15H2,1-5H3,(H,34,38)/t18?,24-/s2
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US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370041
PNG
(4-((R)-8-((R)-2-(2-Fluoro-5-(trifluoromethyl)benza...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N([C@@H](C)N(C)C2=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1/C29H32F4N4O5/c1-16(2)23(34-24(38)21-15-19(29(31,32)33)7-10-22(21)30)25(39)36-13-11-28(12-14-36)27(42)35(4)17(3)37(28)20-8-5-18(6-9-20)26(40)41/h5-10,15-17,23H,11-14H2,1-4H3,(H,34,38)(H,40,41)/t17-,23+/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370049
PNG
((R)-4-(8-(2-(5-Cyclopropyl-2-fluorobenzamido)-3-me...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C1CC1)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1/C30H33FN4O6/c1-17(2)24(32-25(36)22-16-20(18-4-5-18)8-11-23(22)31)26(37)34-14-12-30(13-15-34)28(40)33(3)29(41)35(30)21-9-6-19(7-10-21)27(38)39/h6-11,16-18,24H,4-5,12-15H2,1-3H3,(H,32,36)(H,38,39)/t24-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370053
PNG
((R)—N-(1-(1-(4-(2H-Tetrazol-5-yl)phenyl)-3-me...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(OC(F)F)ccc1F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc(cc1)-c1nn[nH]n1
Show InChI InChI=1/C28H29F3N8O5/c1-15(2)21(32-23(40)19-14-18(44-26(30)31)8-9-20(19)29)24(41)38-12-10-28(11-13-38)25(42)37(3)27(43)39(28)17-6-4-16(5-7-17)22-33-35-36-34-22/h4-9,14-15,21,26H,10-13H2,1-3H3,(H,32,40)(H,33,34,35,36)/t21-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370056
PNG
((R)-4-(3-(2-(Dimethylamino)ethyl)-8-(2-(2-fluoro-5...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(CN(CCN(C)C)C2=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1/C31H37F4N5O5/c1-19(2)25(36-26(41)23-17-21(31(33,34)35)7-10-24(23)32)27(42)38-13-11-30(12-14-38)29(45)39(16-15-37(3)4)18-40(30)22-8-5-20(6-9-22)28(43)44/h5-10,17,19,25H,11-16,18H2,1-4H3,(H,36,41)(H,43,44)/t25-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369939
PNG
((R)-2-Fluoro-N-(1-(1-(4-methoxyphenyl)-3-methyl-2,...)
Show SMILES COc1ccc(cc1)N1C(=O)N(C)C(=O)C11CCN(CC1)C(=O)[C@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(C)C
Show InChI InChI=1/C28H30F4N4O5/c1-16(2)22(33-23(37)20-15-17(28(30,31)32)5-10-21(20)29)24(38)35-13-11-27(12-14-35)25(39)34(3)26(40)36(27)18-6-8-19(41-4)9-7-18/h5-10,15-16,22H,11-14H2,1-4H3,(H,33,37)/t22-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370061
PNG
((R)—N-(1-(1-(Benzo[d]oxazol-5-yl)-3-methyl-2,...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc2ocnc2c1
Show InChI InChI=1/C28H27F4N5O5/c1-15(2)22(34-23(38)18-12-16(28(30,31)32)4-6-19(18)29)24(39)36-10-8-27(9-11-36)25(40)35(3)26(41)37(27)17-5-7-21-20(13-17)33-14-42-21/h4-7,12-15,22H,8-11H2,1-3H3,(H,34,38)/t22-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369913
PNG
((R)-2-Fluoro-N-(1-(1-(3-methoxyphenyl)-3-methyl-2,...)
Show SMILES COc1cccc(c1)N1C(=O)N(C)C(=O)C11CCN(CC1)C(=O)[C@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(C)C
Show InChI InChI=1/C28H30F4N4O5/c1-16(2)22(33-23(37)20-14-17(28(30,31)32)8-9-21(20)29)24(38)35-12-10-27(11-13-35)25(39)34(3)26(40)36(27)18-6-5-7-19(15-18)41-4/h5-9,14-16,22H,10-13H2,1-4H3,(H,33,37)/t22-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369937
PNG
(5-Cyclopropyl-2-fluoro-N-((2R,3R)-3-methoxy-1-(1-(...)
Show SMILES COC(C)[C@@H](NC(=O)c1cc(ccc1F)C1CC1)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc(OC)cc1
Show InChI InChI=1/C30H35FN4O6/c1-18(40-3)25(32-26(36)23-17-20(19-5-6-19)7-12-24(23)31)27(37)34-15-13-30(14-16-34)28(38)33(2)29(39)35(30)21-8-10-22(41-4)11-9-21/h7-12,17-19,25H,5-6,13-16H2,1-4H3,(H,32,36)/t18?,25-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369939
PNG
((R)-2-Fluoro-N-(1-(1-(4-methoxyphenyl)-3-methyl-2,...)
Show SMILES COc1ccc(cc1)N1C(=O)N(C)C(=O)C11CCN(CC1)C(=O)[C@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(C)C
Show InChI InChI=1/C28H30F4N4O5/c1-16(2)22(33-23(37)20-15-17(28(30,31)32)5-10-21(20)29)24(38)35-13-11-27(12-14-35)25(39)34(3)26(40)36(27)18-6-8-19(41-4)9-7-18/h5-10,15-16,22H,11-14H2,1-4H3,(H,33,37)/t22-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369945
PNG
((R)—N-(2-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Show SMILES CN1C(=O)N(c2ccc3[nH]ncc3c2)C2(CCN(CC2)C(=O)[C@H](NC(=O)c2cc(ccc2F)C(F)(F)F)C2CCC2)C1=O
Show InChI InChI=1/C29H28F4N6O4/c1-37-26(42)28(39(27(37)43)19-6-8-22-17(13-19)15-34-36-22)9-11-38(12-10-28)25(41)23(16-3-2-4-16)35-24(40)20-14-18(29(31,32)33)5-7-21(20)30/h5-8,13-16,23H,2-4,9-12H2,1H3,(H,34,36)(H,35,40)/t23-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369947
PNG
((R)—N-(1-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(Cl)cc(c1)C(F)(F)F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc2[nH]ncc2c1
Show InChI InChI=1/C28H28ClF3N6O4/c1-15(2)22(34-23(39)16-10-18(28(30,31)32)13-19(29)11-16)24(40)37-8-6-27(7-9-37)25(41)36(3)26(42)38(27)20-4-5-21-17(12-20)14-33-35-21/h4-5,10-15,22H,6-9H2,1-3H3,(H,33,35)(H,34,39)/t22-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369955
PNG
((R)-2-Fluoro-N-(1-(1-(4-methoxybenzyl)-3-methyl-2,...)
Show SMILES COc1ccc(CN2C(=O)N(C)C(=O)C22CCN(CC2)C(=O)[C@H](NC(=O)c2cc(ccc2F)C(F)(F)F)C(C)C)cc1
Show InChI InChI=1/C29H32F4N4O5/c1-17(2)23(34-24(38)21-15-19(29(31,32)33)7-10-22(21)30)25(39)36-13-11-28(12-14-36)26(40)35(3)27(41)37(28)16-18-5-8-20(42-4)9-6-18/h5-10,15,17,23H,11-14,16H2,1-4H3,(H,34,38)/t23-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369957
PNG
((R)—N-(1-(1-((2,3-Dihydrobenzo[b][1,4]dioxin-...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(Cc1ccc3OCCOc3c1)C(=O)N(C)C2=O
Show InChI InChI=1/C30H32F4N4O6/c1-17(2)24(35-25(39)20-15-19(30(32,33)34)5-6-21(20)31)26(40)37-10-8-29(9-11-37)27(41)36(3)28(42)38(29)16-18-4-7-22-23(14-18)44-13-12-43-22/h4-7,14-15,17,24H,8-13,16H2,1-3H3,(H,35,39)/t24-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369977
PNG
(N-((2R,3S)-3-Methoxy-1-(3-methyl-4-oxo-1-phenyl-1,...)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)c1cccc(C)c1)C(=O)N1CCC2(CC1)N(CN(C)C2=O)c1ccccc1
Show InChI InChI=1/C27H34N4O4/c1-19-9-8-10-21(17-19)24(32)28-23(20(2)35-4)25(33)30-15-13-27(14-16-30)26(34)29(3)18-31(27)22-11-6-5-7-12-22/h5-12,17,20,23H,13-16,18H2,1-4H3,(H,28,32)/t20-,23+/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369978
PNG
(3-Ethyl-N-((2R,3S)-3-methoxy-1-(3-methyl-4-oxo-1-p...)
Show SMILES CCc1cccc(c1)C(=O)N[C@H]([C@H](C)OC)C(=O)N1CCC2(CC1)N(CN(C)C2=O)c1ccccc1
Show InChI InChI=1/C28H36N4O4/c1-5-21-10-9-11-22(18-21)25(33)29-24(20(2)36-4)26(34)31-16-14-28(15-17-31)27(35)30(3)19-32(28)23-12-7-6-8-13-23/h6-13,18,20,24H,5,14-17,19H2,1-4H3,(H,29,33)/t20-,24+/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369983
PNG
((R)-2-Fluoro-5-methyl-N-(3-methyl-1-(3-methyl-4-ox...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(C)ccc1F)C(=O)N1CCC2(CC1)N(CN(C)C2=O)c1ccccc1
Show InChI InChI=1/C27H33FN4O3/c1-18(2)23(29-24(33)21-16-19(3)10-11-22(21)28)25(34)31-14-12-27(13-15-31)26(35)30(4)17-32(27)20-8-6-5-7-9-20/h5-11,16,18,23H,12-15,17H2,1-4H3,(H,29,33)/t23-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369985
PNG
((R)-5-Ethyl-2-fluoro-N-(3-methyl-1-(3-methyl-4-oxo...)
Show SMILES CCc1ccc(F)c(c1)C(=O)N[C@H](C(C)C)C(=O)N1CCC2(CC1)N(CN(C)C2=O)c1ccccc1
Show InChI InChI=1/C28H35FN4O3/c1-5-20-11-12-23(29)22(17-20)25(34)30-24(19(2)3)26(35)32-15-13-28(14-16-32)27(36)31(4)18-33(28)21-9-7-6-8-10-21/h6-12,17,19,24H,5,13-16,18H2,1-4H3,(H,30,34)/t24-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369990
PNG
((R)-4-(8-(2-(5-Ethyl-2-fluorobenzamido)-3-methylbu...)
Show SMILES CCc1ccc(F)c(c1)C(=O)N[C@H](C(C)C)C(=O)N1CCC2(CC1)N(CN(C)C2=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1/C29H35FN4O5/c1-5-19-6-11-23(30)22(16-19)25(35)31-24(18(2)3)26(36)33-14-12-29(13-15-33)28(39)32(4)17-34(29)21-9-7-20(8-10-21)27(37)38/h6-11,16,18,24H,5,12-15,17H2,1-4H3,(H,31,35)(H,37,38)/t24-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370001
PNG
((R)-4-(8-(2-(2-Fluoro-5-(trifluoromethoxy)benzamid...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(OC(F)(F)F)ccc1F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1/C28H28F4N4O7/c1-15(2)21(33-22(37)19-14-18(8-9-20(19)29)43-28(30,31)32)23(38)35-12-10-27(11-13-35)25(41)34(3)26(42)36(27)17-6-4-16(5-7-17)24(39)40/h4-9,14-15,21H,10-13H2,1-3H3,(H,33,37)(H,39,40)/t21-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370004
PNG
((R)—N-(1-(1-(4-(Cyanomethoxy)phenyl)-3-methyl...)
Show SMILES CCc1ccc(F)c(c1)C(=O)N[C@H](C(C)C)C(=O)N1CCC2(CC1)N(CN(C)C2=O)c1ccc(OCC#N)cc1
Show InChI InChI=1/C30H36FN5O4/c1-5-21-6-11-25(31)24(18-21)27(37)33-26(20(2)3)28(38)35-15-12-30(13-16-35)29(39)34(4)19-36(30)22-7-9-23(10-8-22)40-17-14-32/h6-11,18,20,26H,5,12-13,15-17,19H2,1-4H3,(H,33,37)/t26-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370011
PNG
((R)—N-(1-(3-(Cyanomethyl)-4-oxo-1-phenyl-1,3,...)
Show SMILES CCc1ccc(F)c(c1)C(=O)N[C@H](C(C)C)C(=O)N1CCC2(CC1)N(CN(CC#N)C2=O)c1ccccc1
Show InChI InChI=1/C29H34FN5O3/c1-4-21-10-11-24(30)23(18-21)26(36)32-25(20(2)3)27(37)33-15-12-29(13-16-33)28(38)34(17-14-31)19-35(29)22-8-6-5-7-9-22/h5-11,18,20,25H,4,12-13,15-17,19H2,1-3H3,(H,32,36)/t25-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370016
PNG
((R)-2-Fluoro-N-(3-methyl-1-(3-methyl-2,4-dioxo-1-p...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc(C)cc1
Show InChI InChI=1/C28H30F4N4O4/c1-16(2)22(33-23(37)20-15-18(28(30,31)32)7-10-21(20)29)24(38)35-13-11-27(12-14-35)25(39)34(4)26(40)36(27)19-8-5-17(3)6-9-19/h5-10,15-16,22H,11-14H2,1-4H3,(H,33,37)/t22-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370023
PNG
((R)—N-(1-(1-(4-Chlorophenyl)-3-methyl-4-oxo-1...)
Show SMILES CC(C)[C@@H](NC(=O)c1cccc(C)c1)C(=O)N1CCC2(CC1)N(CN(C)C2=O)c1ccc(Cl)cc1
Show InChI InChI=1/C27H33ClN4O3/c1-18(2)23(29-24(33)20-7-5-6-19(3)16-20)25(34)31-14-12-27(13-15-31)26(35)30(4)17-32(27)22-10-8-21(28)9-11-22/h5-11,16,18,23H,12-15,17H2,1-4H3,(H,29,33)/t23-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370034
PNG
((R)-2-Fluoro-N-(3-methyl-1-(3-methyl-1-(4-(methyls...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(CN(C)C2=O)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1/C28H32F4N4O5S/c1-17(2)23(33-24(37)21-15-18(28(30,31)32)5-10-22(21)29)25(38)35-13-11-27(12-14-35)26(39)34(3)16-36(27)19-6-8-20(9-7-19)42(4,40)41/h5-10,15,17,23H,11-14,16H2,1-4H3,(H,33,37)/t23-/s2
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US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370039
PNG
(4-((R)-8-((R)-2-(5-Ethyl-2-fluorobenzamido)-3-meth...)
Show SMILES CCc1ccc(F)c(c1)C(=O)N[C@H](C(C)C)C(=O)N1CCC2(CC1)N([C@@H](C)N(C)C2=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1/C30H37FN4O5/c1-6-20-7-12-24(31)23(17-20)26(36)32-25(18(2)3)27(37)34-15-13-30(14-16-34)29(40)33(5)19(4)35(30)22-10-8-21(9-11-22)28(38)39/h7-12,17-19,25H,6,13-16H2,1-5H3,(H,32,36)(H,38,39)/t19-,25+/s2
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US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370043
PNG
((R)—N-(1-(1-(1H-Indazol-5-yl)-3-methyl-4-oxo-...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(CN(C)C2=O)c1ccc2[nH]ncc2c1
Show InChI InChI=1/C28H30F4N6O3/c1-16(2)23(34-24(39)20-13-18(28(30,31)32)4-6-21(20)29)25(40)37-10-8-27(9-11-37)26(41)36(3)15-38(27)19-5-7-22-17(12-19)14-33-35-22/h4-7,12-14,16,23H,8-11,15H2,1-3H3,(H,33,35)(H,34,39)/t23-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM370057
PNG
((R)-2-Fluoro-N-(3-methyl-1-(3-methyl-2,4-dioxo-1-(...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccncc1
Show InChI InChI=1/C26H27F4N5O4/c1-15(2)20(32-21(36)18-14-16(26(28,29)30)4-5-19(18)27)22(37)34-12-8-25(9-13-34)23(38)33(3)24(39)35(25)17-6-10-31-11-7-17/h4-7,10-11,14-15,20H,8-9,12-13H2,1-3H3,(H,32,36)/t20-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369929
PNG
((R)-5-Ethyl-2-fluoro-N-(3-methyl-1-(3-methyl-2,4-d...)
Show SMILES CCc1ccc(F)c(c1)C(=O)N[C@H](C(C)C)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccccc1
Show InChI InChI=1/C28H33FN4O4/c1-5-19-11-12-22(29)21(17-19)24(34)30-23(18(2)3)25(35)32-15-13-28(14-16-32)26(36)31(4)27(37)33(28)20-9-7-6-8-10-20/h6-12,17-18,23H,5,13-16H2,1-4H3,(H,30,34)/t23-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369935
PNG
((R)-5-Cyclopropyl-2-fluoro-N-(1-(1-(4-methoxypheny...)
Show SMILES COc1ccc(cc1)N1C(=O)N(C)C(=O)C11CCN(CC1)C(=O)[C@H](NC(=O)c1cc(ccc1F)C1CC1)C(C)C
Show InChI InChI=1/C30H35FN4O5/c1-18(2)25(32-26(36)23-17-20(19-5-6-19)7-12-24(23)31)27(37)34-15-13-30(14-16-34)28(38)33(3)29(39)35(30)21-8-10-22(40-4)11-9-21/h7-12,17-19,25H,5-6,13-16H2,1-4H3,(H,32,36)/t25-/s2
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US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369940
PNG
((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc2[nH]ncc2c1
Show InChI InChI=1/C28H28F4N6O4/c1-15(2)22(34-23(39)19-13-17(28(30,31)32)4-6-20(19)29)24(40)37-10-8-27(9-11-37)25(41)36(3)26(42)38(27)18-5-7-21-16(12-18)14-33-35-21/h4-7,12-15,22H,8-11H2,1-3H3,(H,33,35)(H,34,39)/t22-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
Autotaxin


(Homo sapiens (Human))
BDBM369948
PNG
((R)—N-(1-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(OC(F)(F)F)ccc1F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc2[nH]ncc2c1
Show InChI InChI=1/C28H28F4N6O5/c1-15(2)22(34-23(39)19-13-18(5-6-20(19)29)43-28(30,31)32)24(40)37-10-8-27(9-11-37)25(41)36(3)26(42)38(27)17-4-7-21-16(12-17)14-33-35-21/h4-7,12-15,22H,8-11H2,1-3H3,(H,33,35)(H,34,39)/t22-/s2
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X-Rx, Inc.

US Patent


Assay Description
The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...


US Patent US10233182 (2019)

More data for this
Ligand-Target Pair
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