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Patent code US10238638

Compile Data Set for Download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370580
PNG
(US10238638, Example 9)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N2CCOC[C@H]2CO)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1/C29H26N6O5S3/c1-16-33-35-11-23(32-29(35)42-16)27-31-22-9-21(38-2)10-24(25(22)43-27)40-13-19-15-41-26(30-19)17-3-5-18(6-4-17)28(37)34-7-8-39-14-20(34)12-36/h3-6,9-11,15,20,36H,7-8,12-14H2,1-2H3/t20-/s2
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n/an/a 330n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370593
PNG
(US10238638, Example 22)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(C)C2CCOCC2)c2sc(nc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1S/C31H28F2N6O4S3/c1-31(32,33)29-37-39-14-23(36-30(39)46-29)27-35-22-12-21(41-3)13-24(25(22)45-27)43-15-19-16-44-26(34-19)17-4-6-18(7-5-17)28(40)38(2)20-8-10-42-11-9-20/h4-7,12-14,16,20H,8-11,15H2,1-3H3
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n/an/a 760n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370592
PNG
(US10238638, Example 21)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N2CCOC[C@H]2CO)c2sc(nc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1/C30H26F2N6O5S3/c1-30(31,32)28-36-38-11-22(35-29(38)46-28)26-34-21-9-20(41-2)10-23(24(21)45-26)43-13-18-15-44-25(33-18)16-3-5-17(6-4-16)27(40)37-7-8-42-14-19(37)12-39/h3-6,9-11,15,19,39H,7-8,12-14H2,1-2H3/t19-/s2
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n/an/a 920n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370620
PNG
(US10238638, Example 67)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N2CCC(C)(CO)CC2)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1S/C31H30N6O4S3/c1-18-35-37-14-24(34-30(37)43-18)28-33-23-12-22(40-3)13-25(26(23)44-28)41-15-21-16-42-27(32-21)19-4-6-20(7-5-19)29(39)36-10-8-31(2,17-38)9-11-36/h4-7,12-14,16,38H,8-11,15,17H2,1-3H3
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n/an/a 930n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370581
PNG
(US10238638, Example 10)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(C)C2CCOCC2)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1S/C30H28N6O4S3/c1-17-34-36-14-24(33-30(36)42-17)28-32-23-12-22(38-3)13-25(26(23)43-28)40-15-20-16-41-27(31-20)18-4-6-19(7-5-18)29(37)35(2)21-8-10-39-11-9-21/h4-7,12-14,16,21H,8-11,15H2,1-3H3
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n/an/a 980n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370497
PNG
(US10238638, Example 5)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(C)CC#N)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1S/C27H21N7O3S3/c1-15-32-34-12-21(31-27(34)39-15)25-30-20-10-19(36-3)11-22(23(20)40-25)37-13-18-14-38-24(29-18)16-4-6-17(7-5-16)26(35)33(2)9-8-28/h4-7,10-12,14H,9,13H2,1-3H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370613
PNG
(US10238638, Example 42)
Show SMILES COc1cc(OCc2nc(sc2C)-c2ccc(cc2)C(=O)N2CCC(CCO)CC2)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1S/C32H32N6O4S3/c1-18-26(34-29(43-18)21-4-6-22(7-5-21)31(40)37-11-8-20(9-12-37)10-13-39)17-42-27-15-23(41-3)14-24-28(27)45-30(33-24)25-16-38-32(35-25)44-19(2)36-38/h4-7,14-16,20,39H,8-13,17H2,1-3H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370598
PNG
(US10238638, Example 27)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(C)CC#N)c2sc(nc2c1)-c1cn2nc(sc2n1)C1CC1
Show InChI InChI=1S/C29H23N7O3S3/c1-35(10-9-30)28(37)18-7-5-16(6-8-18)25-31-19(15-40-25)14-39-23-12-20(38-2)11-21-24(23)41-27(32-21)22-13-36-29(33-22)42-26(34-36)17-3-4-17/h5-8,11-13,15,17H,3-4,10,14H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370591
PNG
(US10238638, Example 20)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N2CC[C@@H](CO)C2)c2sc(nc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1/C30H26F2N6O4S3/c1-30(31,32)28-36-38-12-22(35-29(38)45-28)26-34-21-9-20(41-2)10-23(24(21)44-26)42-14-19-15-43-25(33-19)17-3-5-18(6-4-17)27(40)37-8-7-16(11-37)13-39/h3-6,9-10,12,15-16,39H,7-8,11,13-14H2,1-2H3/t16-/s2
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n/an/a 1.20E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370606
PNG
(US10238638, Example 35)
Show SMILES CCc1nn2cc(nc2s1)-c1nc2cc(OC)cc(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)C)c2s1
Show InChI InChI=1S/C27H24N6O3S3/c1-5-22-31-33-12-20(30-27(33)38-22)25-29-19-10-18(35-4)11-21(23(19)39-25)36-13-17-14-37-24(28-17)15-6-8-16(9-7-15)26(34)32(2)3/h6-12,14H,5,13H2,1-4H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370607
PNG
(US10238638, Example 36)
Show SMILES CCc1nn2cc(nc2s1)-c1nc2cc(OC)cc(OCc3csc(n3)-c3ccc(cc3)C(=O)N3CCC(CCO)CC3)c2s1
Show InChI InChI=1S/C32H32N6O4S3/c1-3-27-36-38-16-25(35-32(38)44-27)30-34-24-14-23(41-2)15-26(28(24)45-30)42-17-22-18-43-29(33-22)20-4-6-21(7-5-20)31(40)37-11-8-19(9-12-37)10-13-39/h4-7,14-16,18-19,39H,3,8-13,17H2,1-2H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370605
PNG
(US10238638, Example 34)
Show SMILES CCc1nn2cc(nc2s1)-c1nc2cc(OC)cc(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)[C@H]3CCOC3)c2s1
Show InChI InChI=1/C30H28N6O4S3/c1-4-25-34-36-13-23(33-30(36)42-25)28-32-22-11-21(38-3)12-24(26(22)43-28)40-14-19-16-41-27(31-19)17-5-7-18(8-6-17)29(37)35(2)20-9-10-39-15-20/h5-8,11-13,16,20H,4,9-10,14-15H2,1-3H3/t20-/s2
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n/an/a 1.30E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370582
PNG
(US10238638, Example 11)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N2CCOC[C@@H]2CO)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1/C29H26N6O5S3/c1-16-33-35-11-23(32-29(35)42-16)27-31-22-9-21(38-2)10-24(25(22)43-27)40-13-19-15-41-26(30-19)17-3-5-18(6-4-17)28(37)34-7-8-39-14-20(34)12-36/h3-6,9-11,15,20,36H,7-8,12-14H2,1-2H3/t20-/s2
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n/an/a 1.40E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370603
PNG
(US10238638, Example 32)
Show SMILES CCc1nn2cc(nc2s1)-c1nc2cc(OC)cc(OCc3csc(n3)-c3ccc(cc3)C(=O)NCC(C)(C)CO)c2s1
Show InChI InChI=1S/C30H30N6O4S3/c1-5-24-35-36-12-22(34-29(36)42-24)28-33-21-10-20(39-4)11-23(25(21)43-28)40-13-19-14-41-27(32-19)18-8-6-17(7-9-18)26(38)31-15-30(2,3)16-37/h6-12,14,37H,5,13,15-16H2,1-4H3,(H,31,38)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370608
PNG
((S)-(3-Hydroxypiperidin-1-yl)(4-(4-(((5-methoxy-2-...)
Show SMILES COc1cc(OCc2nc(sc2C)-c2ccc(cc2)C(=O)N2CCC[C@H](O)C2)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1/C30H28N6O4S3/c1-16-24(32-27(41-16)18-6-8-19(9-7-18)29(38)35-10-4-5-20(37)13-35)15-40-25-12-21(39-3)11-22-26(25)43-28(31-22)23-14-36-30(33-23)42-17(2)34-36/h6-9,11-12,14,20,37H,4-5,10,13,15H2,1-3H3/t20-/s2
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n/an/a 1.60E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370610
PNG
(US10238638, Example 40)
Show SMILES COc1cc(OCc2nc(sc2C)-c2ccc(cc2)C(=O)NCC(C)(C)CO)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1S/C30H30N6O4S3/c1-16-23(33-27(41-16)19-8-6-18(7-9-19)26(38)31-14-30(3,4)15-37)13-40-24-11-20(39-5)10-21-25(24)43-28(32-21)22-12-36-29(34-22)42-17(2)35-36/h6-12,37H,13-15H2,1-5H3,(H,31,38)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370612
PNG
(US10238638, Example 41)
Show SMILES COc1cc(OCc2nc(sc2C)-c2ccc(cc2)C(=O)N(C)C)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1S/C27H24N6O3S3/c1-14-21(29-24(37-14)16-6-8-17(9-7-16)26(34)32(3)4)13-36-22-11-18(35-5)10-19-23(22)39-25(28-19)20-12-33-27(30-20)38-15(2)31-33/h6-12H,13H2,1-5H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370616
PNG
(5-Methoxy-2-(6-methylimidazo[1,2-b]pyridazin-2-yl)...)
Show SMILES COc1cc(OCc2csc(n2)-c2ccccc2)c2sc(nc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C25H19N5O2S2/c1-15-8-9-22-27-20(12-30(22)29-15)25-28-19-10-18(31-2)11-21(23(19)34-25)32-13-17-14-33-24(26-17)16-6-4-3-5-7-16/h3-12,14H,13H2,1-2H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370579
PNG
(US10238638, Example 8)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N2CC[C@@H](CO)C2)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1/C29H26N6O4S3/c1-16-33-35-12-23(32-29(35)41-16)27-31-22-9-21(38-2)10-24(25(22)42-27)39-14-20-15-40-26(30-20)18-3-5-19(6-4-18)28(37)34-8-7-17(11-34)13-36/h3-6,9-10,12,15,17,36H,7-8,11,13-14H2,1-2H3/t17-/s2
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n/an/a 1.80E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370609
PNG
(US10238638, Example 39)
Show SMILES COc1cc(OCc2nc(sc2C)-c2ccc(cc2)C(=O)N(C)[C@H]2CCOC2)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1/C30H28N6O4S3/c1-16-24(32-27(41-16)18-5-7-19(8-6-18)29(37)35(3)20-9-10-39-14-20)15-40-25-12-21(38-4)11-22-26(25)43-28(31-22)23-13-36-30(33-23)42-17(2)34-36/h5-8,11-13,20H,9-10,14-15H2,1-4H3/t20-/s2
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n/an/a 1.80E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370602
PNG
(US10238638, Example 31 | tert-Butyl 4-(4-(((2-(2-e...)
Show SMILES CCc1nn2cc(nc2s1)-c1nc2cc(OC)cc(OCc3csc(n3)-c3ccc(cc3)C(=O)OC(C)(C)C)c2s1
Show InChI InChI=1S/C29H27N5O4S3/c1-6-23-33-34-13-21(32-28(34)40-23)26-31-20-11-19(36-5)12-22(24(20)41-26)37-14-18-15-39-25(30-18)16-7-9-17(10-8-16)27(35)38-29(2,3)4/h7-13,15H,6,14H2,1-5H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370432
PNG
(US10238638, Example 1)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)OC(C)(C)C)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1S/C28H25N5O4S3/c1-15-32-33-12-21(31-27(33)39-15)25-30-20-10-19(35-5)11-22(23(20)40-25)36-13-18-14-38-24(29-18)16-6-8-17(9-7-16)26(34)37-28(2,3)4/h6-12,14H,13H2,1-5H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370617
PNG
(US10238638, Example 46)
Show SMILES COc1cc(OCc2csc(n2)N2CCOCC2)c2sc(nc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C23H22N6O3S2/c1-14-3-4-20-25-18(11-29(20)27-14)22-26-17-9-16(30-2)10-19(21(17)34-22)32-12-15-13-33-23(24-15)28-5-7-31-8-6-28/h3-4,9-11,13H,5-8,12H2,1-2H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370588
PNG
(US10238638, Example 17)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(C)CC#N)c2sc(nc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1S/C28H21F2N7O3S3/c1-28(29,30)26-35-37-12-20(34-27(37)43-26)24-33-19-10-18(39-3)11-21(22(19)42-24)40-13-17-14-41-23(32-17)15-4-6-16(7-5-15)25(38)36(2)9-8-31/h4-7,10-12,14H,9,13H2,1-3H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370615
PNG
(4-(4-(((5-Methoxy-2-(6-methylimidazo[1,2-b]pyridaz...)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(C)C)c2sc(nc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C28H24N6O3S2/c1-16-5-10-24-30-22(13-34(24)32-16)27-31-21-11-20(36-4)12-23(25(21)39-27)37-14-19-15-38-26(29-19)17-6-8-18(9-7-17)28(35)33(2)3/h5-13,15H,14H2,1-4H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370596
PNG
((S)-4-(4-(((2-(2-Cyclopropylimidazo[2,1-b][1,3,4]t...)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(C)[C@H]2CCOC2)c2sc(nc2c1)-c1cn2nc(sc2n1)C1CC1
Show InChI InChI=1/C31H28N6O4S3/c1-36(21-9-10-40-15-21)30(38)19-7-5-17(6-8-19)27-32-20(16-42-27)14-41-25-12-22(39-2)11-23-26(25)43-29(33-23)24-13-37-31(34-24)44-28(35-37)18-3-4-18/h5-8,11-13,16,18,21H,3-4,9-10,14-15H2,1-2H3/t21-/s2
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n/an/a 2.60E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370450
PNG
(US10238638, Example 3)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(C)[C@H]2CCOC2)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1/C29H26N6O4S3/c1-16-33-35-12-23(32-29(35)41-16)27-31-22-10-21(37-3)11-24(25(22)42-27)39-13-19-15-40-26(30-19)17-4-6-18(7-5-17)28(36)34(2)20-8-9-38-14-20/h4-7,10-12,15,20H,8-9,13-14H2,1-3H3/t20-/s2
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n/an/a 3.60E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370604
PNG
(US10238638, Example 33)
Show SMILES CCc1nn2cc(nc2s1)-c1nc2cc(OC)cc(OCc3csc(n3)-c3ccc(cc3)C(=O)N3CCC[C@H](O)C3)c2s1
Show InChI InChI=1/C30H28N6O4S3/c1-3-25-34-36-14-23(33-30(36)42-25)28-32-22-11-21(39-2)12-24(26(22)43-28)40-15-19-16-41-27(31-19)17-6-8-18(9-7-17)29(38)35-10-4-5-20(37)13-35/h6-9,11-12,14,16,20,37H,3-5,10,13,15H2,1-2H3/t20-/s2
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n/an/a 3.60E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370599
PNG
(US10238638, Example 28)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(C)C)c2sc(nc2c1)-c1cn2nc(sc2n1)C1CC1
Show InChI InChI=1S/C28H24N6O3S3/c1-33(2)27(35)17-8-6-15(7-9-17)24-29-18(14-38-24)13-37-22-11-19(36-3)10-20-23(22)39-26(30-20)21-12-34-28(31-21)40-25(32-34)16-4-5-16/h6-12,14,16H,4-5,13H2,1-3H3
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n/an/a 3.70E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370586
PNG
(US10238638, Example 15)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(C)[C@H]2CCOC2)c2sc(nc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1/C30H26F2N6O4S3/c1-30(31,32)28-36-38-12-22(35-29(38)45-28)26-34-21-10-20(40-3)11-23(24(21)44-26)42-13-18-15-43-25(33-18)16-4-6-17(7-5-16)27(39)37(2)19-8-9-41-14-19/h4-7,10-12,15,19H,8-9,13-14H2,1-3H3/t19-/s2
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n/an/a 3.70E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370498
PNG
(US10238638, Example 6)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(C)C)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1S/C26H22N6O3S3/c1-14-30-32-11-20(29-26(32)37-14)24-28-19-9-18(34-4)10-21(22(19)38-24)35-12-17-13-36-23(27-17)15-5-7-16(8-6-15)25(33)31(2)3/h5-11,13H,12H2,1-4H3
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n/an/a 3.80E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370496
PNG
(US10238638, Example 4)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N2CCC[C@H](O)C2)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1/C29H26N6O4S3/c1-16-33-35-13-23(32-29(35)41-16)27-31-22-10-21(38-2)11-24(25(22)42-27)39-14-19-15-40-26(30-19)17-5-7-18(8-6-17)28(37)34-9-3-4-20(36)12-34/h5-8,10-11,13,15,20,36H,3-4,9,12,14H2,1-2H3/t20-/s2
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n/an/a 4.20E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370589
PNG
(US10238638, Example 18)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(C)C)c2sc(nc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1S/C27H22F2N6O3S3/c1-27(28,29)25-33-35-11-19(32-26(35)41-25)23-31-18-9-17(37-4)10-20(21(18)40-23)38-12-16-13-39-22(30-16)14-5-7-15(8-6-14)24(36)34(2)3/h5-11,13H,12H2,1-4H3
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n/an/a 5.10E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370618
PNG
((S)-4-(4-(((5-Methoxy-2-(6-methylimidazo[1,2-b]pyr...)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(C)[C@H]2CCOC2)c2sc(nc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1/C31H28N6O4S2/c1-18-4-9-27-33-25(14-37(27)35-18)30-34-24-12-23(39-3)13-26(28(24)43-30)41-15-21-17-42-29(32-21)19-5-7-20(8-6-19)31(38)36(2)22-10-11-40-16-22/h4-9,12-14,17,22H,10-11,15-16H2,1-3H3/t22-/s2
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n/an/a 6.40E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370597
PNG
(US10238638, Example 26)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N2CCC[C@H](O)C2)c2sc(nc2c1)-c1cn2nc(sc2n1)C1CC1
Show InChI InChI=1/C31H28N6O4S3/c1-40-22-11-23-26(43-29(33-23)24-14-37-31(34-24)44-28(35-37)18-4-5-18)25(12-22)41-15-20-16-42-27(32-20)17-6-8-19(9-7-17)30(39)36-10-2-3-21(38)13-36/h6-9,11-12,14,16,18,21,38H,2-5,10,13,15H2,1H3/t21-/s2
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n/an/a 9.10E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370619
PNG
(US10238638, Example 48)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N2CCC[C@H](O)C2)c2sc(nc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1/C31H28N6O4S2/c1-18-5-10-27-33-25(15-37(27)35-18)30-34-24-12-23(40-2)13-26(28(24)43-30)41-16-21-17-42-29(32-21)19-6-8-20(9-7-19)31(39)36-11-3-4-22(38)14-36/h5-10,12-13,15,17,22,38H,3-4,11,14,16H2,1-2H3/t22-/s2
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n/an/a 9.90E+3n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370587
PNG
(US10238638, Example 16)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N2CCC[C@H](O)C2)c2sc(nc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1/C30H26F2N6O4S3/c1-30(31,32)28-36-38-13-22(35-29(38)45-28)26-34-21-10-20(41-2)11-23(24(21)44-26)42-14-18-15-43-25(33-18)16-5-7-17(8-6-16)27(40)37-9-3-4-19(39)12-37/h5-8,10-11,13,15,19,39H,3-4,9,12,14H2,1-2H3/t19-/s2
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n/an/a 1.50E+4n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370499
PNG
(US10238638, Example 7)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(CCO)C(C)(C)C)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1S/C30H30N6O4S3/c1-17-34-36-14-23(33-29(36)42-17)27-32-22-12-21(39-5)13-24(25(22)43-27)40-15-20-16-41-26(31-20)18-6-8-19(9-7-18)28(38)35(10-11-37)30(2,3)4/h6-9,12-14,16,37H,10-11,15H2,1-5H3
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n/an/a 3.00E+4n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370449
PNG
(US10238638, Example 2)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(O)=O)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Show InChI InChI=1S/C24H17N5O4S3/c1-12-28-29-9-18(27-24(29)35-12)22-26-17-7-16(32-2)8-19(20(17)36-22)33-10-15-11-34-21(25-15)13-3-5-14(6-4-13)23(30)31/h3-9,11H,10H2,1-2H3,(H,30,31)
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n/an/a 4.50E+4n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370600
PNG
(US10238638, Example 29)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(CCO)C(C)(C)C)c2sc(nc2c1)-c1cn2nc(sc2n1)C1CC1
Show InChI InChI=1S/C32H32N6O4S3/c1-32(2,3)37(11-12-39)30(40)20-9-7-18(8-10-20)27-33-21(17-43-27)16-42-25-14-22(41-4)13-23-26(25)44-29(34-23)24-15-38-31(35-24)45-28(36-38)19-5-6-19/h7-10,13-15,17,19,39H,5-6,11-12,16H2,1-4H3
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n/an/a 8.00E+4n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370590
PNG
(US10238638, Example 19)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N(CCO)C(C)(C)C)c2sc(nc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1S/C31H30F2N6O4S3/c1-30(2,3)38(10-11-40)27(41)18-8-6-17(7-9-18)25-34-19(16-44-25)15-43-23-13-20(42-5)12-21-24(23)45-26(35-21)22-14-39-29(36-22)46-28(37-39)31(4,32)33/h6-9,12-14,16,40H,10-11,15H2,1-5H3
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n/an/a 8.10E+4n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370585
PNG
(US10238638, Example 14)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(O)=O)c2sc(nc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1S/C25H17F2N5O4S3/c1-25(26,27)23-31-32-9-17(30-24(32)39-23)21-29-16-7-15(35-2)8-18(19(16)38-21)36-10-14-11-37-20(28-14)12-3-5-13(6-4-12)22(33)34/h3-9,11H,10H2,1-2H3,(H,33,34)
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n/an/a 8.70E+4n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370601
PNG
(US10238638, Example 30)
Show SMILES CCc1nn2cc(nc2s1)-c1nc2cc(OC)cc(OCc3ccccc3)c2s1
Show InChI InChI=1S/C21H18N4O2S2/c1-3-18-24-25-11-16(23-21(25)28-18)20-22-15-9-14(26-2)10-17(19(15)29-20)27-12-13-7-5-4-6-8-13/h4-11H,3,12H2,1-2H3
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n/an/a 3.20E+5n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370595
PNG
(US10238638, Example 24 | tert-Butyl 4-(4-(((2-(2-c...)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)OC(C)(C)C)c2sc(nc2c1)-c1cn2nc(sc2n1)C1CC1
Show InChI InChI=1S/C30H27N5O4S3/c1-30(2,3)39-28(36)18-9-7-16(8-10-18)25-31-19(15-40-25)14-38-23-12-20(37-4)11-21-24(23)41-27(32-21)22-13-35-29(33-22)42-26(34-35)17-5-6-17/h7-13,15,17H,5-6,14H2,1-4H3
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n/an/a 3.80E+5n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370614
PNG
(US10238638, Example 43)
Show SMILES COc1cc(OCc2ccccc2)c2sc(nc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C22H18N4O2S/c1-14-8-9-20-23-18(12-26(20)25-14)22-24-17-10-16(27-2)11-19(21(17)29-22)28-13-15-6-4-3-5-7-15/h3-12H,13H2,1-2H3
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n/an/a 5.00E+5n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370584
PNG
(US10238638, Example 13 | tert-Butyl 4-(4-(((2-(2-(...)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)OC(C)(C)C)c2sc(nc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1S/C29H25F2N5O4S3/c1-28(2,3)40-25(37)16-8-6-15(7-9-16)23-32-17(14-41-23)13-39-21-11-18(38-5)10-19-22(21)42-24(33-19)20-12-36-27(34-20)43-26(35-36)29(4,30)31/h6-12,14H,13H2,1-5H3
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n/an/a 8.00E+5n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370594
PNG
(US10238638, Example 23)
Show SMILES COc1cc(OCc2ccccc2)c2sc(nc2c1)-c1cn2nc(sc2n1)C1CC1
Show InChI InChI=1S/C22H18N4O2S2/c1-27-15-9-16-19(18(10-15)28-12-13-5-3-2-4-6-13)29-21(23-16)17-11-26-22(24-17)30-20(25-26)14-7-8-14/h2-6,9-11,14H,7-8,12H2,1H3
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n/an/a 8.30E+5n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM370583
PNG
(7-(Benzyloxy)-2-(2-(1,1-difluoroethyl)imidazo[2,1-...)
Show SMILES COc1cc(OCc2ccccc2)c2sc(nc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1S/C21H16F2N4O2S2/c1-21(22,23)19-26-27-10-15(25-20(27)31-19)18-24-14-8-13(28-2)9-16(17(14)30-18)29-11-12-6-4-3-5-7-12/h3-10H,11H2,1-2H3
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n/an/a 3.20E+6n/an/an/an/an/an/a



Universite De Montreal; Bristol-Myers Squibb Company

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US10238638 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%