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Patent code US10238658

Compile Data Set for Download or QSAR
Found 120 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM142598
PNG
(US10238658, Example Reference | US8933228, Ref 2 |...)
Show SMILES COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1
Show InChI InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41)
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n/an/a 5n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330278
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES CC(C)c1ccccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)n1
Show InChI InChI=1S/C38H39N7O2/c1-24(2)27-11-9-10-14-30(27)40-36-39-22-21-35(43-36)47-32-20-19-31(28-12-7-8-13-29(28)32)41-37(46)42-34-23-33(38(4,5)6)44-45(34)26-17-15-25(3)16-18-26/h7-24H,1-6H3,(H,39,40,43)(H2,41,42,46)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM142598
PNG
(US10238658, Example Reference | US8933228, Ref 2 |...)
Show SMILES COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1
Show InChI InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM161376
PNG
(US10238658, Example 1 | US9108950, 1 | US9724347, ...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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n/an/a 22n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330279
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H35N7O2/c1-23-14-16-25(17-15-23)43-32(22-31(42-43)36(3,4)5)40-35(44)39-29-18-19-30(27-12-8-7-11-26(27)29)45-33-20-21-37-34(41-33)38-28-13-9-6-10-24(28)2/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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n/an/a 33n/an/an/an/an/an/a



RESPIVERT LIMITED

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Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330282
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H35N7O3/c1-22-10-12-24(13-11-22)43-32(21-31(42-43)36(3,4)5)40-35(45)39-29-16-17-30(27-9-7-6-8-26(27)29)46-33-18-19-37-34(41-33)38-28-15-14-25(44)20-23(28)2/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45)
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Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM142598
PNG
(US10238658, Example Reference | US8933228, Ref 2 |...)
Show SMILES COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1
Show InChI InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41)
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RESPIVERT LIMITED

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Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM142598
PNG
(US10238658, Example Reference | US8933228, Ref 2 |...)
Show SMILES COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1
Show InChI InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41)
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Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM161376
PNG
(US10238658, Example 1 | US9108950, 1 | US9724347, ...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330291
PNG
(1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O4/c1-35(2,3)30-21-31(42(41-30)23-11-15-25(45-4)16-12-23)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)46-32-19-20-36-33(40-32)37-22-9-13-24(43)14-10-22/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44)
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US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330288
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3F)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O3/c1-21-9-11-22(12-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-15-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-28-14-13-23(44)19-26(28)36/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45)
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Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330283
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)ccc1O
Show InChI InChI=1S/C36H35N7O4/c1-22-10-13-24(14-11-22)43-32(21-31(42-43)36(2,3)4)40-35(45)39-27-15-17-29(26-9-7-6-8-25(26)27)47-33-18-19-37-34(41-33)38-23-12-16-28(44)30(20-23)46-5/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45)
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Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330275
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1
Show InChI InChI=1S/C36H35N7O3/c1-23-10-14-25(15-11-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-29-18-19-30(28-9-7-6-8-27(28)29)46-33-20-21-37-34(41-33)38-24-12-16-26(45-5)17-13-24/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330264
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3Cl)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330285
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1OC
Show InChI InChI=1S/C37H37N7O4/c1-23-11-14-25(15-12-23)44-33(22-32(43-44)37(2,3)4)41-36(45)40-28-16-18-29(27-10-8-7-9-26(27)28)48-34-19-20-38-35(42-34)39-24-13-17-30(46-5)31(21-24)47-6/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45)
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Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330289
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3Cl)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O3/c1-21-9-11-22(12-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-15-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-28-14-13-23(44)19-26(28)36/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45)
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Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330272
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1cccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c1
Show InChI InChI=1S/C36H35N7O3/c1-23-13-15-25(16-14-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-29-17-18-30(28-12-7-6-11-27(28)29)46-33-19-20-37-34(41-33)38-24-9-8-10-26(21-24)45-5/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330276
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(Cl)cc3C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H34ClN7O2/c1-22-10-13-25(14-11-22)44-32(21-31(43-44)36(3,4)5)41-35(45)40-29-16-17-30(27-9-7-6-8-26(27)29)46-33-18-19-38-34(42-33)39-28-15-12-24(37)20-23(28)2/h6-21H,1-5H3,(H,38,39,42)(H2,40,41,45)
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Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM370631
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c(OC)c1
Show InChI InChI=1S/C37H37N7O4/c1-23-11-13-24(14-12-23)44-33(22-32(43-44)37(2,3)4)41-36(45)40-28-17-18-30(27-10-8-7-9-26(27)28)48-34-19-20-38-35(42-34)39-29-16-15-25(46-5)21-31(29)47-6/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45)
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n/an/a 151n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330273
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(F)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O2/c1-22-12-14-25(15-13-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-16-17-29(27-11-6-5-10-26(27)28)45-32-18-19-37-33(41-32)38-24-9-7-8-23(36)20-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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n/an/a 155n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330264
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3Cl)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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n/an/a 161n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330263
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)n1
Show InChI InChI=1S/C36H35N7O3/c1-23-14-16-24(17-15-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-27-18-19-29(26-11-7-6-10-25(26)27)46-33-20-21-37-34(41-33)38-28-12-8-9-13-30(28)45-5/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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n/an/a 161n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330260
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O3/c1-22-9-13-24(14-10-22)42-31(21-30(41-42)35(2,3)4)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-36-33(40-32)37-23-11-15-25(43)16-12-23/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44)
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n/an/a 164n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330262
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3F)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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n/an/a 165n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330270
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-lH-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(C)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H35N7O2/c1-23-13-15-26(16-14-23)43-32(22-31(42-43)36(3,4)5)40-35(44)39-29-17-18-30(28-12-7-6-11-27(28)29)45-33-19-20-37-34(41-33)38-25-10-8-9-24(2)21-25/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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n/an/a 169n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330265
PNG
(1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O3/c1-35(2,3)30-22-31(42(41-30)24-14-16-25(44-4)17-15-24)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)45-32-20-21-36-33(40-32)37-23-10-6-5-7-11-23/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330260
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O3/c1-22-9-13-24(14-10-22)42-31(21-30(41-42)35(2,3)4)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-36-33(40-32)37-23-11-15-25(43)16-12-23/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM370625
PNG
(1-(3-(tert-butyl)-1-(4-hydroxyphenyl)-1H-pyrazol-5...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)n3)c3ccccc23)n(n1)-c1ccc(O)cc1
Show InChI InChI=1S/C34H31N7O3/c1-34(2,3)29-21-30(41(40-29)23-13-15-24(42)16-14-23)38-33(43)37-27-17-18-28(26-12-8-7-11-25(26)27)44-31-19-20-35-32(39-31)36-22-9-5-4-6-10-22/h4-21,42H,1-3H3,(H,35,36,39)(H2,37,38,43)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330290
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3O)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O4/c1-21-9-11-22(12-10-21)42-31(20-30(41-42)35(2,3)4)39-34(45)38-26-15-16-29(25-8-6-5-7-24(25)26)46-32-17-18-36-33(40-32)37-27-14-13-23(43)19-28(27)44/h5-20,43-44H,1-4H3,(H,36,37,40)(H2,38,39,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330268
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(C)ccc3C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C37H37N7O2/c1-23-12-15-26(16-13-23)44-33(22-32(43-44)37(4,5)6)41-36(45)40-29-17-18-31(28-10-8-7-9-27(28)29)46-34-19-20-38-35(42-34)39-30-21-24(2)11-14-25(30)3/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45)
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n/an/a 195n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330281
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(F)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O2/c1-22-9-15-25(16-10-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-37-33(41-32)38-24-13-11-23(36)12-14-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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n/an/a 212n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330271
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(Cl)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O2/c1-22-12-14-25(15-13-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-16-17-29(27-11-6-5-10-26(27)28)45-32-18-19-37-33(41-32)38-24-9-7-8-23(36)20-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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n/an/a 262n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330291
PNG
(1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O4/c1-35(2,3)30-21-31(42(41-30)23-11-15-25(45-4)16-12-23)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)46-32-19-20-36-33(40-32)37-22-9-13-24(43)14-10-22/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44)
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n/an/a 264n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330283
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)ccc1O
Show InChI InChI=1S/C36H35N7O4/c1-22-10-13-24(14-11-22)43-32(21-31(42-43)36(2,3)4)40-35(45)39-27-15-17-29(26-9-7-6-8-25(26)27)47-33-18-19-37-34(41-33)38-23-12-16-28(44)30(20-23)46-5/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330280
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES CCOc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1
Show InChI InChI=1S/C37H37N7O3/c1-6-46-27-17-13-25(14-18-27)39-35-38-22-21-34(42-35)47-31-20-19-30(28-9-7-8-10-29(28)31)40-36(45)41-33-23-32(37(3,4)5)43-44(33)26-15-11-24(2)12-16-26/h7-23H,6H2,1-5H3,(H,38,39,42)(H2,40,41,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330287
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)c(F)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O3/c1-21-9-12-23(13-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-14-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-22-11-15-28(44)26(36)19-22/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45)
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US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM161376
PNG
(US10238658, Example 1 | US9108950, 1 | US9724347, ...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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n/an/a 334n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM142598
PNG
(US10238658, Example Reference | US8933228, Ref 2 |...)
Show SMILES COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1
Show InChI InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41)
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US Patent
n/an/a 344n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330269
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1
Show InChI InChI=1S/C36H35N7O2/c1-23-10-14-25(15-11-23)38-34-37-21-20-33(41-34)45-30-19-18-29(27-8-6-7-9-28(27)30)39-35(44)40-32-22-31(36(3,4)5)42-43(32)26-16-12-24(2)13-17-26/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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n/an/a 356n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330287
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)c(F)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O3/c1-21-9-12-23(13-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-14-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-22-11-15-28(44)26(36)19-22/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45)
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n/an/a 423n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330285
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1OC
Show InChI InChI=1S/C37H37N7O4/c1-23-11-14-25(15-12-23)44-33(22-32(43-44)37(2,3)4)41-36(45)40-28-16-18-29(27-10-8-7-9-26(27)28)48-34-19-20-38-35(42-34)39-24-13-17-30(46-5)31(21-24)47-6/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45)
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n/an/a 535n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330284
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(C)c(O)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H35N7O3/c1-22-10-14-25(15-11-22)43-32(21-31(42-43)36(3,4)5)40-35(45)39-28-16-17-30(27-9-7-6-8-26(27)28)46-33-18-19-37-34(41-33)38-24-13-12-23(2)29(44)20-24/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45)
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n/an/a 549n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330260
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O3/c1-22-9-13-24(14-10-22)42-31(21-30(41-42)35(2,3)4)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-36-33(40-32)37-23-11-15-25(43)16-12-23/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44)
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n/an/a 557n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330274
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(Cl)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O2/c1-22-9-15-25(16-10-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-37-33(41-32)38-24-13-11-23(36)12-14-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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n/an/a 616n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330282
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H35N7O3/c1-22-10-12-24(13-11-22)43-32(21-31(42-43)36(3,4)5)40-35(45)39-29-16-17-30(27-9-7-6-8-26(27)29)46-33-18-19-37-34(41-33)38-28-15-14-25(44)20-23(28)2/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45)
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n/an/a 695n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330260
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O3/c1-22-9-13-24(14-10-22)42-31(21-30(41-42)35(2,3)4)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-36-33(40-32)37-23-11-15-25(43)16-12-23/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44)
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n/an/a 760n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM330286
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1Cl
Show InChI InChI=1S/C36H34ClN7O3/c1-22-10-13-24(14-11-22)44-32(21-31(43-44)36(2,3)4)41-35(45)40-28-15-17-29(26-9-7-6-8-25(26)28)47-33-18-19-38-34(42-33)39-23-12-16-30(46-5)27(37)20-23/h6-21H,1-5H3,(H,38,39,42)(H2,40,41,45)
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n/an/a 1.42E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM370625
PNG
(1-(3-(tert-butyl)-1-(4-hydroxyphenyl)-1H-pyrazol-5...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)n3)c3ccccc23)n(n1)-c1ccc(O)cc1
Show InChI InChI=1S/C34H31N7O3/c1-34(2,3)29-21-30(41(40-29)23-13-15-24(42)16-14-23)38-33(43)37-27-17-18-28(26-12-8-7-11-25(26)27)44-31-19-20-35-32(39-31)36-22-9-5-4-6-10-22/h4-21,42H,1-3H3,(H,35,36,39)(H2,37,38,43)
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n/an/a 1.50E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330286
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1Cl
Show InChI InChI=1S/C36H34ClN7O3/c1-22-10-13-24(14-11-22)44-32(21-31(43-44)36(2,3)4)41-35(45)40-28-15-17-29(26-9-7-6-8-25(26)28)47-33-18-19-38-34(42-33)39-23-12-16-30(46-5)27(37)20-23/h6-21H,1-5H3,(H,38,39,42)(H2,40,41,45)
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n/an/a>1.54E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330286
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1Cl
Show InChI InChI=1S/C36H34ClN7O3/c1-22-10-13-24(14-11-22)44-32(21-31(43-44)36(2,3)4)41-35(45)40-28-15-17-29(26-9-7-6-8-25(26)28)47-33-18-19-38-34(42-33)39-23-12-16-30(46-5)27(37)20-23/h6-21H,1-5H3,(H,38,39,42)(H2,40,41,45)
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n/an/a>1.54E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330289
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3Cl)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O3/c1-21-9-11-22(12-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-15-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-28-14-13-23(44)19-26(28)36/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330289
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3Cl)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O3/c1-21-9-11-22(12-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-15-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-28-14-13-23(44)19-26(28)36/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330283
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)ccc1O
Show InChI InChI=1S/C36H35N7O4/c1-22-10-13-24(14-11-22)43-32(21-31(42-43)36(2,3)4)40-35(45)39-27-15-17-29(26-9-7-6-8-25(26)27)47-33-18-19-37-34(41-33)38-23-12-16-28(44)30(20-23)46-5/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330282
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H35N7O3/c1-22-10-12-24(13-11-22)43-32(21-31(42-43)36(3,4)5)40-35(45)39-29-16-17-30(27-9-7-6-8-26(27)29)46-33-18-19-37-34(41-33)38-28-15-14-25(44)20-23(28)2/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45)
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US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330280
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES CCOc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1
Show InChI InChI=1S/C37H37N7O3/c1-6-46-27-17-13-25(14-18-27)39-35-38-22-21-34(42-35)47-31-20-19-30(28-9-7-8-10-29(28)31)40-36(45)41-33-23-32(37(3,4)5)43-44(33)26-15-11-24(2)12-16-26/h7-23H,6H2,1-5H3,(H,38,39,42)(H2,40,41,45)
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Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330280
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES CCOc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1
Show InChI InChI=1S/C37H37N7O3/c1-6-46-27-17-13-25(14-18-27)39-35-38-22-21-34(42-35)47-31-20-19-30(28-9-7-8-10-29(28)31)40-36(45)41-33-23-32(37(3,4)5)43-44(33)26-15-11-24(2)12-16-26/h7-23H,6H2,1-5H3,(H,38,39,42)(H2,40,41,45)
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n/an/a>1.59E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330290
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3O)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O4/c1-21-9-11-22(12-10-21)42-31(20-30(41-42)35(2,3)4)39-34(45)38-26-15-16-29(25-8-6-5-7-24(25)26)46-32-17-18-36-33(40-32)37-27-14-13-23(43)19-28(27)44/h5-20,43-44H,1-4H3,(H,36,37,40)(H2,38,39,45)
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n/an/a>1.62E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330288
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3F)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O3/c1-21-9-11-22(12-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-15-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-28-14-13-23(44)19-26(28)36/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330288
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3F)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O3/c1-21-9-11-22(12-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-15-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-28-14-13-23(44)19-26(28)36/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45)
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n/an/a>1.62E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330290
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3O)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O4/c1-21-9-11-22(12-10-21)42-31(20-30(41-42)35(2,3)4)39-34(45)38-26-15-16-29(25-8-6-5-7-24(25)26)46-32-17-18-36-33(40-32)37-27-14-13-23(43)19-28(27)44/h5-20,43-44H,1-4H3,(H,36,37,40)(H2,38,39,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330287
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)c(F)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O3/c1-21-9-12-23(13-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-14-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-22-11-15-28(44)26(36)19-22/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330284
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(C)c(O)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H35N7O3/c1-22-10-14-25(15-11-22)43-32(21-31(42-43)36(3,4)5)40-35(45)39-28-16-17-30(27-9-7-6-8-26(27)28)46-33-18-19-37-34(41-33)38-24-13-12-23(2)29(44)20-24/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330284
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(C)c(O)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H35N7O3/c1-22-10-14-25(15-11-22)43-32(21-31(42-43)36(3,4)5)40-35(45)39-28-16-17-30(27-9-7-6-8-26(27)28)46-33-18-19-37-34(41-33)38-24-13-12-23(2)29(44)20-24/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45)
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n/an/a>1.63E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330281
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(F)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O2/c1-22-9-15-25(16-10-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-37-33(41-32)38-24-13-11-23(36)12-14-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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n/an/a>1.66E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330281
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(F)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O2/c1-22-9-15-25(16-10-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-37-33(41-32)38-24-13-11-23(36)12-14-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330279
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H35N7O2/c1-23-14-16-25(17-15-23)43-32(22-31(42-43)36(3,4)5)40-35(44)39-29-18-19-30(27-12-8-7-11-26(27)29)45-33-20-21-37-34(41-33)38-28-13-9-6-10-24(28)2/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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n/an/a>1.67E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330279
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H35N7O2/c1-23-14-16-25(17-15-23)43-32(22-31(42-43)36(3,4)5)40-35(44)39-29-18-19-30(27-12-8-7-11-26(27)29)45-33-20-21-37-34(41-33)38-28-13-9-6-10-24(28)2/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330260
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O3/c1-22-9-13-24(14-10-22)42-31(21-30(41-42)35(2,3)4)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-36-33(40-32)37-23-11-15-25(43)16-12-23/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330265
PNG
(1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O3/c1-35(2,3)30-22-31(42(41-30)24-14-16-25(44-4)17-15-24)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)45-32-20-21-36-33(40-32)37-23-10-6-5-7-11-23/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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n/an/a 1.70E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330285
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1OC
Show InChI InChI=1S/C37H37N7O4/c1-23-11-14-25(15-12-23)44-33(22-32(43-44)37(2,3)4)41-36(45)40-28-16-18-29(27-10-8-7-9-26(27)28)48-34-19-20-38-35(42-34)39-24-13-17-30(46-5)31(21-24)47-6/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330291
PNG
(1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O4/c1-35(2,3)30-21-31(42(41-30)23-11-15-25(45-4)16-12-23)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)46-32-19-20-36-33(40-32)37-22-9-13-24(43)14-10-22/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44)
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n/an/a 2.38E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM370625
PNG
(1-(3-(tert-butyl)-1-(4-hydroxyphenyl)-1H-pyrazol-5...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)n3)c3ccccc23)n(n1)-c1ccc(O)cc1
Show InChI InChI=1S/C34H31N7O3/c1-34(2,3)29-21-30(41(40-29)23-13-15-24(42)16-14-23)38-33(43)37-27-17-18-28(26-12-8-7-11-25(26)27)44-31-19-20-35-32(39-31)36-22-9-5-4-6-10-22/h4-21,42H,1-3H3,(H,35,36,39)(H2,37,38,43)
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n/an/a 2.49E+3n/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330260
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O3/c1-22-9-13-24(14-10-22)42-31(21-30(41-42)35(2,3)4)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-36-33(40-32)37-23-11-15-25(43)16-12-23/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44)
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US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330265
PNG
(1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O3/c1-35(2,3)30-22-31(42(41-30)24-14-16-25(44-4)17-15-24)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)45-32-20-21-36-33(40-32)37-23-10-6-5-7-11-23/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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n/an/a 3.51E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM161376
PNG
(US10238658, Example 1 | US9108950, 1 | US9724347, ...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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n/an/a 3.74E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330262
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3F)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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n/an/a 8.20E+3n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330264
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3Cl)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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n/an/a>1.51E+4n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330264
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3Cl)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM370631
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c(OC)c1
Show InChI InChI=1S/C37H37N7O4/c1-23-11-13-24(14-12-23)44-33(22-32(43-44)37(2,3)4)41-36(45)40-28-17-18-30(27-10-8-7-9-26(27)28)48-34-19-20-38-35(42-34)39-29-16-15-25(46-5)21-31(29)47-6/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM370631
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c(OC)c1
Show InChI InChI=1S/C37H37N7O4/c1-23-11-13-24(14-12-23)44-33(22-32(43-44)37(2,3)4)41-36(45)40-28-17-18-30(27-10-8-7-9-26(27)28)48-34-19-20-38-35(42-34)39-29-16-15-25(46-5)21-31(29)47-6/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330276
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(Cl)cc3C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H34ClN7O2/c1-22-10-13-25(14-11-22)44-32(21-31(43-44)36(3,4)5)41-35(45)40-29-16-17-30(27-9-7-6-8-26(27)29)46-33-18-19-38-34(42-33)39-28-15-12-24(37)20-23(28)2/h6-21H,1-5H3,(H,38,39,42)(H2,40,41,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330276
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(Cl)cc3C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H34ClN7O2/c1-22-10-13-25(14-11-22)44-32(21-31(43-44)36(3,4)5)41-35(45)40-29-16-17-30(27-9-7-6-8-26(27)29)46-33-18-19-38-34(42-33)39-28-15-12-24(37)20-23(28)2/h6-21H,1-5H3,(H,38,39,42)(H2,40,41,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330278
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES CC(C)c1ccccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)n1
Show InChI InChI=1S/C38H39N7O2/c1-24(2)27-11-9-10-14-30(27)40-36-39-22-21-35(43-36)47-32-20-19-31(28-12-7-8-13-29(28)32)41-37(46)42-34-23-33(38(4,5)6)44-45(34)26-17-15-25(3)16-18-26/h7-24H,1-6H3,(H,39,40,43)(H2,41,42,46)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330278
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES CC(C)c1ccccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)n1
Show InChI InChI=1S/C38H39N7O2/c1-24(2)27-11-9-10-14-30(27)40-36-39-22-21-35(43-36)47-32-20-19-31(28-12-7-8-13-29(28)32)41-37(46)42-34-23-33(38(4,5)6)44-45(34)26-17-15-25(3)16-18-26/h7-24H,1-6H3,(H,39,40,43)(H2,41,42,46)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330274
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(Cl)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O2/c1-22-9-15-25(16-10-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-37-33(41-32)38-24-13-11-23(36)12-14-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330264
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3Cl)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330271
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(Cl)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O2/c1-22-12-14-25(15-13-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-16-17-29(27-11-6-5-10-26(27)28)45-32-18-19-37-33(41-32)38-24-9-7-8-23(36)20-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330274
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(Cl)cc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O2/c1-22-9-15-25(16-10-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-37-33(41-32)38-24-13-11-23(36)12-14-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330271
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(Cl)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O2/c1-22-12-14-25(15-13-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-16-17-29(27-11-6-5-10-26(27)28)45-32-18-19-37-33(41-32)38-24-9-7-8-23(36)20-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330264
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3Cl)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32ClN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330263
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)n1
Show InChI InChI=1S/C36H35N7O3/c1-23-14-16-24(17-15-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-27-18-19-29(26-11-7-6-10-25(26)27)46-33-20-21-37-34(41-33)38-28-12-8-9-13-30(28)45-5/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330275
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1
Show InChI InChI=1S/C36H35N7O3/c1-23-10-14-25(15-11-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-29-18-19-30(28-9-7-6-8-27(28)29)46-33-20-21-37-34(41-33)38-24-12-16-26(45-5)17-13-24/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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n/an/a>1.63E+4n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330275
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1
Show InChI InChI=1S/C36H35N7O3/c1-23-10-14-25(15-11-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-29-18-19-30(28-9-7-6-8-27(28)29)46-33-20-21-37-34(41-33)38-24-12-16-26(45-5)17-13-24/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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n/an/a>1.63E+4n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330268
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(C)ccc3C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C37H37N7O2/c1-23-12-15-26(16-13-23)44-33(22-32(43-44)37(4,5)6)41-36(45)40-29-17-18-31(28-10-8-7-9-27(28)29)46-34-19-20-38-35(42-34)39-30-21-24(2)11-14-25(30)3/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330272
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1cccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c1
Show InChI InChI=1S/C36H35N7O3/c1-23-13-15-25(16-14-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-29-17-18-30(28-12-7-6-11-27(28)29)46-33-19-20-37-34(41-33)38-24-9-8-10-26(21-24)45-5/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330263
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1ccccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)n1
Show InChI InChI=1S/C36H35N7O3/c1-23-14-16-24(17-15-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-27-18-19-29(26-11-7-6-10-25(26)27)46-33-20-21-37-34(41-33)38-28-12-8-9-13-30(28)45-5/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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n/an/a>1.63E+4n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330272
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES COc1cccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c1
Show InChI InChI=1S/C36H35N7O3/c1-23-13-15-25(16-14-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-29-17-18-30(28-12-7-6-11-27(28)29)46-33-19-20-37-34(41-33)38-24-9-8-10-26(21-24)45-5/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330268
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(C)ccc3C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C37H37N7O2/c1-23-12-15-26(16-13-23)44-33(22-32(43-44)37(4,5)6)41-36(45)40-29-17-18-31(28-10-8-7-9-27(28)29)46-34-19-20-38-35(42-34)39-30-21-24(2)11-14-25(30)3/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330262
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3F)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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n/an/a>1.66E+4n/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330273
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(F)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O2/c1-22-12-14-25(15-13-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-16-17-29(27-11-6-5-10-26(27)28)45-32-18-19-37-33(41-32)38-24-9-7-8-23(36)20-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330273
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(F)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H32FN7O2/c1-22-12-14-25(15-13-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-16-17-29(27-11-6-5-10-26(27)28)45-32-18-19-37-33(41-32)38-24-9-7-8-23(36)20-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330270
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-lH-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(C)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H35N7O2/c1-23-13-15-26(16-14-23)43-32(22-31(42-43)36(3,4)5)40-35(44)39-29-17-18-30(28-12-7-6-11-27(28)29)45-33-19-20-37-34(41-33)38-25-10-8-9-24(2)21-25/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330269
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1
Show InChI InChI=1S/C36H35N7O2/c1-23-10-14-25(15-11-23)38-34-37-21-20-33(41-34)45-30-19-18-29(27-8-6-7-9-28(27)30)39-35(44)40-32-22-31(36(3,4)5)42-43(32)26-16-12-24(2)13-17-26/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM330270
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-lH-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(C)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H35N7O2/c1-23-13-15-26(16-14-23)43-32(22-31(42-43)36(3,4)5)40-35(44)39-29-17-18-30(28-12-7-6-11-27(28)29)45-33-19-20-37-34(41-33)38-25-10-8-9-24(2)21-25/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM330269
PNG
(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Show SMILES Cc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1
Show InChI InChI=1S/C36H35N7O2/c1-23-10-14-25(15-11-23)38-34-37-21-20-33(41-34)45-30-19-18-29(27-8-6-7-9-28(27)30)39-35(44)40-32-22-31(36(3,4)5)42-43(32)26-16-12-24(2)13-17-26/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM161376
PNG
(US10238658, Example 1 | US9108950, 1 | US9724347, ...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM161376
PNG
(US10238658, Example 1 | US9108950, 1 | US9724347, ...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM161376
PNG
(US10238658, Example 1 | US9108950, 1 | US9724347, ...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM142598
PNG
(US10238658, Example Reference | US8933228, Ref 2 |...)
Show SMILES COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1
Show InChI InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41)
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n/an/an/a 5n/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM142598
PNG
(US10238658, Example Reference | US8933228, Ref 2 |...)
Show SMILES COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1
Show InChI InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41)
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n/an/an/a 24n/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM161376
PNG
(US10238658, Example 1 | US9108950, 1 | US9724347, ...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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n/an/an/a 14n/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM142598
PNG
(US10238658, Example Reference | US8933228, Ref 2 |...)
Show SMILES COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1
Show InChI InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41)
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n/an/an/a 9n/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM161376
PNG
(US10238658, Example 1 | US9108950, 1 | US9724347, ...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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n/an/an/a 43n/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM161376
PNG
(US10238658, Example 1 | US9108950, 1 | US9724347, ...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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n/an/an/a 20n/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM161376
PNG
(US10238658, Example 1 | US9108950, 1 | US9724347, ...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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n/an/an/a 10n/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM142598
PNG
(US10238658, Example Reference | US8933228, Ref 2 |...)
Show SMILES COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1
Show InChI InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41)
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n/an/an/a 5n/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM142598
PNG
(US10238658, Example Reference | US8933228, Ref 2 |...)
Show SMILES COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1
Show InChI InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41)
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n/an/an/a 180n/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM142598
PNG
(US10238658, Example Reference | US8933228, Ref 2 |...)
Show SMILES COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1
Show InChI InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41)
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n/an/an/a 4n/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM142598
PNG
(US10238658, Example Reference | US8933228, Ref 2 |...)
Show SMILES COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1
Show InChI InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41)
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n/an/an/a 1n/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM161376
PNG
(US10238658, Example 1 | US9108950, 1 | US9724347, ...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
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n/an/an/a 1.20E+3n/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...


US Patent US10238658 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%