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Patent code US10239840

Compile Data Set for Download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370883
PNG
(US10239840, Example 13)
Show SMILES COc1cc(ccc1F)C(=O)N1CCc2c(C)c([C@H](OC(C)(C)C)C(O)=O)c(c(C)c2CC1)-c1cc(F)c2OCCCc2c1C
Show InChI InChI=1/C36H41F2NO6/c1-19-25-9-8-16-44-32(25)28(38)18-26(19)30-20(2)23-12-14-39(34(40)22-10-11-27(37)29(17-22)43-7)15-13-24(23)21(3)31(30)33(35(41)42)45-36(4,5)6/h10-11,17-18,33H,8-9,12-16H2,1-7H3,(H,41,42)/t33-/s2
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n/an/a 4n/an/an/an/an/an/a



VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370878
PNG
(US10239840, Example 8)
Show SMILES COc1ccc(C)cc1C(=O)N1CCc2c(C)c([C@H](OC(C)(C)C)C(O)=O)c(c(C)c2CC1)-c1cc(F)c2OCCCc2c1C
Show InChI InChI=1/C37H44FNO6/c1-20-11-12-30(43-8)28(18-20)35(40)39-15-13-24-22(3)31(27-19-29(38)33-26(21(27)2)10-9-17-44-33)32(23(4)25(24)14-16-39)34(36(41)42)45-37(5,6)7/h11-12,18-19,34H,9-10,13-17H2,1-8H3,(H,41,42)/t34-/s2
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n/an/a 4n/an/an/an/an/an/a



VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370877
PNG
(US10239840, Example 7)
Show SMILES COc1ccc(F)cc1C(=O)N1CCc2c(C)c([C@H](OC(C)(C)C)C(O)=O)c(c(C)c2CC1)-c1cc(F)c2OCCCc2c1C
Show InChI InChI=1/C36H41F2NO6/c1-19-25-9-8-16-44-32(25)28(38)18-26(19)30-20(2)23-12-14-39(34(40)27-17-22(37)10-11-29(27)43-7)15-13-24(23)21(3)31(30)33(35(41)42)45-36(4,5)6/h10-11,17-18,33H,8-9,12-16H2,1-7H3,(H,41,42)/t33-/s2
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n/an/a 5n/an/an/an/an/an/a



VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370880
PNG
(US10239840, Example 10)
Show SMILES COc1c(F)cccc1C(=O)N1CCc2c(C)c([C@H](OC(C)(C)C)C(O)=O)c(c(C)c2CC1)-c1cc(F)c2OCCCc2c1C
Show InChI InChI=1/C36H41F2NO6/c1-19-24-11-9-17-44-32(24)28(38)18-26(19)29-20(2)22-13-15-39(34(40)25-10-8-12-27(37)31(25)43-7)16-14-23(22)21(3)30(29)33(35(41)42)45-36(4,5)6/h8,10,12,18,33H,9,11,13-17H2,1-7H3,(H,41,42)/t33-/s2
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VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370875
PNG
(US10239840, Example 5)
Show SMILES Cc1c2CCCOc2c(F)cc1-c1c(C)c2CCN(CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)C(=O)c1cccc(F)c1
Show InChI InChI=1/C35H39F2NO5/c1-19-26-11-8-16-42-31(26)28(37)18-27(19)29-20(2)24-12-14-38(33(39)22-9-7-10-23(36)17-22)15-13-25(24)21(3)30(29)32(34(40)41)43-35(4,5)6/h7,9-10,17-18,32H,8,11-16H2,1-6H3,(H,40,41)/t32-/s2
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VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370892
PNG
(US10239840, Example 21)
Show SMILES Cc1c2CCCOc2c(F)cc1-c1c(C)c2CCN(CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)S(=O)(=O)N1CCCCC1
Show InChI InChI=1/C33H45FN2O6S/c1-20-25-11-10-18-41-30(25)27(34)19-26(20)28-21(2)23-12-16-36(43(39,40)35-14-8-7-9-15-35)17-13-24(23)22(3)29(28)31(32(37)38)42-33(4,5)6/h19,31H,7-18H2,1-6H3,(H,37,38)/t31-/s2
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n/an/a 8n/an/an/an/an/an/a



VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370893
PNG
(US10239840, Example 22)
Show SMILES Cc1c2CCCOc2c(F)cc1-c1c(C)c2CCN(CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)C(=O)N1CCCCC1
Show InChI InChI=1/C34H45FN2O5/c1-20-25-11-10-18-41-30(25)27(35)19-26(20)28-21(2)23-12-16-37(33(40)36-14-8-7-9-15-36)17-13-24(23)22(3)29(28)31(32(38)39)42-34(4,5)6/h19,31H,7-18H2,1-6H3,(H,38,39)/t31-/s2
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n/an/a 9n/an/an/an/an/an/a



VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370881
PNG
(US10239840, Example 11)
Show SMILES Cc1c2CCCOc2c(F)cc1-c1c(C)c2CCN(CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)C(=O)c1cccc2CCOc12
Show InChI InChI=1/C37H42FNO6/c1-20-26-11-8-17-43-33(26)29(38)19-28(20)30-21(2)24-12-15-39(35(40)27-10-7-9-23-14-18-44-32(23)27)16-13-25(24)22(3)31(30)34(36(41)42)45-37(4,5)6/h7,9-10,19,34H,8,11-18H2,1-6H3,(H,41,42)/t34-/s2
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VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370888
PNG
(US10239840, Example 17)
Show SMILES Cc1c2CCCOc2c(F)cc1-c1c(C)c2CCN(CC3CCCCC3)CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1/C35H48FNO4/c1-21-27-13-10-18-40-32(27)29(36)19-28(21)30-22(2)25-14-16-37(20-24-11-8-7-9-12-24)17-15-26(25)23(3)31(30)33(34(38)39)41-35(4,5)6/h19,24,33H,7-18,20H2,1-6H3,(H,38,39)/t33-/s2
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n/an/a 10n/an/an/an/an/an/a



VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370889
PNG
(US10239840, Example 18)
Show SMILES Cc1c2CCCOc2c(F)cc1-c1c(C)c2CCN(CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)C1CCCCC1
Show InChI InChI=1/C34H46FNO4/c1-20-26-13-10-18-39-31(26)28(35)19-27(20)29-21(2)24-14-16-36(23-11-8-7-9-12-23)17-15-25(24)22(3)30(29)32(33(37)38)40-34(4,5)6/h19,23,32H,7-18H2,1-6H3,(H,37,38)/t32-/s2
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n/an/a 13n/an/an/an/an/an/a



VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370886
PNG
(US10239840, Example 16)
Show SMILES Cc1c2CCCOc2c(F)cc1-c1c(C)c2CCN(CCC3CCCCC3)CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1/C36H50FNO4/c1-22-28-13-10-20-41-33(28)30(37)21-29(22)31-23(2)26-15-18-38(17-14-25-11-8-7-9-12-25)19-16-27(26)24(3)32(31)34(35(39)40)42-36(4,5)6/h21,25,34H,7-20H2,1-6H3,(H,39,40)/t34-/s2
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VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370879
PNG
(US10239840, Example 9)
Show SMILES COc1ccc(cc1C)C(=O)N1CCc2c(C)c([C@H](OC(C)(C)C)C(O)=O)c(c(C)c2CC1)-c1cc(F)c2OCCCc2c1C
Show InChI InChI=1/C37H44FNO6/c1-20-18-24(11-12-30(20)43-8)35(40)39-15-13-25-22(3)31(28-19-29(38)33-27(21(28)2)10-9-17-44-33)32(23(4)26(25)14-16-39)34(36(41)42)45-37(5,6)7/h11-12,18-19,34H,9-10,13-17H2,1-8H3,(H,41,42)/t34-/s2
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VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370884
PNG
(US10239840, Example 14)
Show SMILES Cc1c2CCCOc2c(F)cc1-c1c(C)c2CCN(CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)C(=O)C(=O)N1CCCCC1
Show InChI InChI=1/C35H45FN2O6/c1-20-25-11-10-18-43-30(25)27(36)19-26(20)28-21(2)23-12-16-38(33(40)32(39)37-14-8-7-9-15-37)17-13-24(23)22(3)29(28)31(34(41)42)44-35(4,5)6/h19,31H,7-18H2,1-6H3,(H,41,42)/t31-/s2
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VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370882
PNG
(US10239840, Example 12)
Show SMILES Cc1c2CCCOc2c(F)cc1-c1c(C)c2CCN(CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)C(=O)C1CCCCC1
Show InChI InChI=1/C35H46FNO5/c1-20-26-13-10-18-41-31(26)28(36)19-27(20)29-21(2)24-14-16-37(33(38)23-11-8-7-9-12-23)17-15-25(24)22(3)30(29)32(34(39)40)42-35(4,5)6/h19,23,32H,7-18H2,1-6H3,(H,39,40)/t32-/s2
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VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370871
PNG
(US10239840, Example 1)
Show SMILES Cc1c2CCCOc2c(Cl)cc1-c1c(C)c2CCN(CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)C(=O)c1cccc(F)c1
Show InChI InChI=1/C35H39ClFNO5/c1-19-26-11-8-16-42-31(26)28(36)18-27(19)29-20(2)24-12-14-38(33(39)22-9-7-10-23(37)17-22)15-13-25(24)21(3)30(29)32(34(40)41)43-35(4,5)6/h7,9-10,17-18,32H,8,11-16H2,1-6H3,(H,40,41)/t32-/s2
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VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370874
PNG
(US10239840, Example 4)
Show SMILES Cc1ccc(cc1)-c1c(C)c2CCN(CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)C(=O)c1cccc(F)c1
Show InChI InChI=1/C32H36FNO4/c1-19-10-12-22(13-11-19)27-20(2)25-14-16-34(30(35)23-8-7-9-24(33)18-23)17-15-26(25)21(3)28(27)29(31(36)37)38-32(4,5)6/h7-13,18,29H,14-17H2,1-6H3,(H,36,37)/t29-/s2
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VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370891
PNG
(US10239840, Example 20)
Show SMILES Cc1c2CCCOc2c(F)cc1-c1c(C)c2CCN(CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)S(=O)(=O)C1CCCCC1
Show InChI InChI=1/C34H46FNO6S/c1-20-26-13-10-18-41-31(26)28(35)19-27(20)29-21(2)24-14-16-36(43(39,40)23-11-8-7-9-12-23)17-15-25(24)22(3)30(29)32(33(37)38)42-34(4,5)6/h19,23,32H,7-18H2,1-6H3,(H,37,38)/t32-/s2
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n/an/a 42n/an/an/an/an/an/a



VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370876
PNG
(US10239840, Example 6)
Show SMILES Cc1c2CCCOc2c(F)cc1-c1c(C)c2CCN(CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)C(=O)CC(C)(C)C
Show InChI InChI=1/C34H46FNO5/c1-19-24-11-10-16-40-30(24)26(35)17-25(19)28-20(2)22-12-14-36(27(37)18-33(4,5)6)15-13-23(22)21(3)29(28)31(32(38)39)41-34(7,8)9/h17,31H,10-16,18H2,1-9H3,(H,38,39)/t31-/s2
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n/an/a 60n/an/an/an/an/an/a



VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370872
PNG
(US10239840, Example 2)
Show SMILES COc1ccc(cc1)-c1c(C)c2CCN(CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)C(=O)c1cccc(F)c1
Show InChI InChI=1/C32H36FNO5/c1-19-25-14-16-34(30(35)22-8-7-9-23(33)18-22)17-15-26(25)20(2)28(29(31(36)37)39-32(3,4)5)27(19)21-10-12-24(38-6)13-11-21/h7-13,18,29H,14-17H2,1-6H3,(H,36,37)/t29-/s2
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n/an/a 76n/an/an/an/an/an/a



VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370885
PNG
(US10239840, Example 15)
Show SMILES Cc1c2CCCOc2c(F)cc1-c1c(C)c2CCN(Cc3cccc(F)c3)CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1/C35H41F2NO4/c1-20-27-11-8-16-41-32(27)29(37)18-28(20)30-21(2)25-12-14-38(19-23-9-7-10-24(36)17-23)15-13-26(25)22(3)31(30)33(34(39)40)42-35(4,5)6/h7,9-10,17-18,33H,8,11-16,19H2,1-6H3,(H,39,40)/t33-/s2
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n/an/a 77n/an/an/an/an/an/a



VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370890
PNG
(US10239840, Example 19)
Show SMILES Cc1c2CCCOc2c(F)cc1-c1c(C)c2CCN(CCc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)c1ccccc1
Show InChI InChI=1/C34H40FNO4/c1-20-26-13-10-18-39-31(26)28(35)19-27(20)29-21(2)24-14-16-36(23-11-8-7-9-12-23)17-15-25(24)22(3)30(29)32(33(37)38)40-34(4,5)6/h7-9,11-12,19,32H,10,13-18H2,1-6H3,(H,37,38)/t32-/s2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 92n/an/an/an/an/an/a



VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
Protein Tax-1


(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
BDBM370873
PNG
(US10239840, Example 3)
Show SMILES Cc1c2CCN(CCc2c(C)c(-c2ccccc2)c1[C@H](OC(C)(C)C)C(O)=O)C(=O)c1cccc(F)c1
Show InChI InChI=1/C31H34FNO4/c1-19-24-14-16-33(29(34)22-12-9-13-23(32)18-22)17-15-25(24)20(2)27(26(19)21-10-7-6-8-11-21)28(30(35)36)37-31(3,4)5/h6-13,18,28H,14-17H2,1-5H3,(H,35,36)/t28-/s2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 219n/an/an/an/an/an/a



VIIV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10239840 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%