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Patent code US10239843

Compile Data Set for Download or QSAR

Found 681 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371055
PNG
(US10239843, Example 162)
Show SMILES Cc1ncc(Cn2c(=O)n(Cc3sc(C)nc3C)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)s1
Show InChI InChI=1S/C23H25N5O4S3/c1-13-20(34-15(3)25-13)12-27-19-6-5-17(35(31,32)26-23(4)7-8-23)9-18(19)21(29)28(22(27)30)11-16-10-24-14(2)33-16/h5-6,9-10,26H,7-8,11-12H2,1-4H3
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n/an/a 4n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371063
PNG
(US10239843, Example 170)
Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(C)CC2)s1
Show InChI InChI=1S/C23H26N6O4S2/c1-14-20(34-15(2)25-14)13-28-19-6-5-17(35(32,33)26-23(3)7-8-23)9-18(19)21(30)29(22(28)31)12-16-10-24-27(4)11-16/h5-6,9-11,26H,7-8,12-13H2,1-4H3
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n/an/a 6n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371355
PNG
(1-[(2,4-Dimethylthiazol-5-yl)methyl]-N-[1-(fluorom...)
Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CF)CC2)s1
Show InChI InChI=1S/C23H25FN6O4S2/c1-14-20(35-15(2)26-14)12-29-19-5-4-17(36(33,34)27-23(13-24)6-7-23)8-18(19)21(31)30(22(29)32)11-16-9-25-28(3)10-16/h4-5,8-10,27H,6-7,11-13H2,1-3H3
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n/an/a 6n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371463
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-3-[(1-methylpyrazo...)
Show SMILES Cc1ncsc1Cn1c2ccc(cc2c(=O)n(Cc2cnn(C)c2)c1=O)S(=O)(=O)NC1(CF)CC1
Show InChI InChI=1S/C22H23FN6O4S2/c1-14-19(34-13-24-14)11-28-18-4-3-16(35(32,33)26-22(12-23)5-6-22)7-17(18)20(30)29(21(28)31)10-15-8-25-27(2)9-15/h3-4,7-9,13,26H,5-6,10-12H2,1-2H3
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n/an/a 7n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371294
PNG
(N-(1-Cyanocyclopropyl)-1-[(2,4-dimethylthiazol-5-y...)
Show SMILES Cc1ncc(Cn2c(=O)n(Cc3sc(C)nc3C)c3ccc(cc3c2=O)S(=O)(=O)NC2(CC2)C#N)s1
Show InChI InChI=1S/C23H22N6O4S3/c1-13-20(35-15(3)26-13)11-28-19-5-4-17(36(32,33)27-23(12-24)6-7-23)8-18(19)21(30)29(22(28)31)10-16-9-25-14(2)34-16/h4-5,8-9,27H,6-7,10-11H2,1-3H3
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n/an/a 8n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371454
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-3-[(1-methylpyrazo...)
Show SMILES Cn1cc(Cn2c(=O)n(Cc3cncs3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Show InChI InChI=1S/C21H21FN6O4S2/c1-26-9-14(7-24-26)10-28-19(29)17-6-16(34(31,32)25-21(12-22)4-5-21)2-3-18(17)27(20(28)30)11-15-8-23-13-33-15/h2-3,6-9,13,25H,4-5,10-12H2,1H3
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n/an/a 8n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371470
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-1-[(5-methylisoxaz...)
Show SMILES Cc1oncc1Cn1c2ccc(cc2c(=O)n(Cc2cnn(C)c2)c1=O)S(=O)(=O)NC1(CF)CC1
Show InChI InChI=1S/C22H23FN6O5S/c1-14-16(9-25-34-14)12-28-19-4-3-17(35(32,33)26-22(13-23)5-6-22)7-18(19)20(30)29(21(28)31)11-15-8-24-27(2)10-15/h3-4,7-10,26H,5-6,11-13H2,1-2H3
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n/an/a 9n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371469
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-1-(isothiazol-5-yl...)
Show SMILES Cn1cc(Cn2c(=O)n(Cc3ccns3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Show InChI InChI=1S/C21H21FN6O4S2/c1-26-10-14(9-23-26)11-28-19(29)17-8-16(34(31,32)25-21(13-22)5-6-21)2-3-18(17)27(20(28)30)12-15-4-7-24-33-15/h2-4,7-10,25H,5-6,11-13H2,1H3
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n/an/a 10n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371267
PNG
(US10239843, Example 374)
Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CC2)C#N)o1
Show InChI InChI=1S/C23H23N7O5S/c1-14-20(35-15(2)26-14)12-29-19-5-4-17(36(33,34)27-23(13-24)6-7-23)8-18(19)21(31)30(22(29)32)11-16-9-25-28(3)10-16/h4-5,8-10,27H,6-7,11-12H2,1-3H3
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n/an/a 11n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371289
PNG
(1-[(2,4-Dimethylthiazol-5-yl)methyl]-7-fluoro-N-(1...)
Show SMILES Cc1nc(C)c(Cn2c3cc(F)c(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(C)CC2)o1
Show InChI InChI=1S/C23H25FN6O5S/c1-13-19(35-14(2)26-13)12-29-18-8-17(24)20(36(33,34)27-23(3)5-6-23)7-16(18)21(31)30(22(29)32)11-15-9-25-28(4)10-15/h7-10,27H,5-6,11-12H2,1-4H3
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n/an/a 11n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371056
PNG
(US10239843, Example 163)
Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnc(C)n3)c2=O)S(=O)(=O)NC2(C)CC2)n(C)n1
Show InChI InChI=1S/C23H26N7O4S/c1-14-9-17(28(4)26-14)13-29-20-6-5-18(35(33,34)27-23(3)7-8-23)10-19(20)21(31)30(22(29)32)12-16-11-24-15(2)25-16/h5-6,9-11,27H,7-8,12-13H2,1-4H3
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n/an/a 12n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371519
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-1-[(1-methylpyrazo...)
Show SMILES Cc1nnc(Cn2c(=O)n(Cc3cnn(C)c3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)s1
Show InChI InChI=1S/C21H22FN7O4S2/c1-13-24-25-18(34-13)11-29-19(30)16-7-15(35(32,33)26-21(12-22)5-6-21)3-4-17(16)28(20(29)31)10-14-8-23-27(2)9-14/h3-4,7-9,26H,5-6,10-12H2,1-2H3
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n/an/a 16n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371506
PNG
(1-[(2,4-Dimethylthiazol-5-yl)methyl]-N-[1-(fluorom...)
Show SMILES Cc1cc(Cn2c(=O)n(Cc3sc(C)nc3C)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)on1
Show InChI InChI=1S/C23H24FN5O5S2/c1-13-8-16(34-26-13)10-29-21(30)18-9-17(36(32,33)27-23(12-24)6-7-23)4-5-19(18)28(22(29)31)11-20-14(2)25-15(3)35-20/h4-5,8-9,27H,6-7,10-12H2,1-3H3
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n/an/a 17n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371066
PNG
(US10239843, Example 173)
Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(C)CC2)n(C)n1
Show InChI InChI=1S/C23H27N7O4S/c1-15-9-17(28(4)25-15)14-29-20-6-5-18(35(33,34)26-23(2)7-8-23)10-19(20)21(31)30(22(29)32)13-16-11-24-27(3)12-16/h5-6,9-12,26H,7-8,13-14H2,1-4H3
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n/an/a 18n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371049
PNG
(US10239843, Example 156)
Show SMILES Cc1ncc(Cn2c(=O)n(CC3CC3)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)s1
Show InChI InChI=1S/C21H24N4O4S2/c1-13-22-10-15(30-13)12-25-19(26)17-9-16(31(28,29)23-21(2)7-8-21)5-6-18(17)24(20(25)27)11-14-3-4-14/h5-6,9-10,14,23H,3-4,7-8,11-12H2,1-2H3
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n/an/a 19n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371479
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-1-[(3-methylimidaz...)
Show SMILES Cn1cc(Cn2c(=O)n(Cc3cncn3C)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Show InChI InChI=1S/C22H24FN7O4S/c1-27-14-24-9-16(27)12-29-19-4-3-17(35(33,34)26-22(13-23)5-6-22)7-18(19)20(31)30(21(29)32)11-15-8-25-28(2)10-15/h3-4,7-10,14,26H,5-6,11-13H2,1-2H3
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n/an/a 19n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371268
PNG
(US10239843, Example 375)
Show SMILES Cc1ncc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CC2)C#N)o1
Show InChI InChI=1S/C22H21N7O5S/c1-14-24-9-16(34-14)12-28-19-4-3-17(35(32,33)26-22(13-23)5-6-22)7-18(19)20(30)29(21(28)31)11-15-8-25-27(2)10-15/h3-4,7-10,26H,5-6,11-12H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371330
PNG
(1-[(2,5-Dimethylpyrazol-3-yl)methyl]-N-[1-(fluorom...)
Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CF)CC2)n(C)n1
Show InChI InChI=1S/C23H26FN7O4S/c1-15-8-17(29(3)26-15)13-30-20-5-4-18(36(34,35)27-23(14-24)6-7-23)9-19(20)21(32)31(22(30)33)12-16-10-25-28(2)11-16/h4-5,8-11,27H,6-7,12-14H2,1-3H3
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n/an/a 23n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371334
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-1-[(3-methylisoxaz...)
Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CF)CC2)on1
Show InChI InChI=1S/C22H23FN6O5S/c1-14-7-16(34-25-14)12-28-19-4-3-17(35(32,33)26-22(13-23)5-6-22)8-18(19)20(30)29(21(28)31)11-15-9-24-27(2)10-15/h3-4,7-10,26H,5-6,11-13H2,1-2H3
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n/an/a 24n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371468
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-1-(isothiazol-4-yl...)
Show SMILES Cn1cc(Cn2c(=O)n(Cc3cnsc3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Show InChI InChI=1S/C21H21FN6O4S2/c1-26-9-14(7-23-26)10-28-19(29)17-6-16(34(31,32)25-21(13-22)4-5-21)2-3-18(17)27(20(28)30)11-15-8-24-33-12-15/h2-3,6-9,12,25H,4-5,10-11,13H2,1H3
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n/an/a 24n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371284
PNG
(7-Fluoro-N-(1-methylcyclopropyl)-1-[(3-methylisoxa...)
Show SMILES Cc1cc(Cn2c3cc(F)c(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(C)CC2)on1
Show InChI InChI=1S/C22H23FN6O5S/c1-13-6-15(34-25-13)12-28-18-8-17(23)19(35(32,33)26-22(2)4-5-22)7-16(18)20(30)29(21(28)31)11-14-9-24-27(3)10-14/h6-10,26H,4-5,11-12H2,1-3H3
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n/an/a 24n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371485
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-3-[(1-methylpyrazo...)
Show SMILES Cc1ncc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CF)CC2)s1
Show InChI InChI=1S/C22H23FN6O4S2/c1-14-24-9-16(34-14)12-28-19-4-3-17(35(32,33)26-22(13-23)5-6-22)7-18(19)20(30)29(21(28)31)11-15-8-25-27(2)10-15/h3-4,7-10,26H,5-6,11-13H2,1-2H3
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n/an/a 25n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371281
PNG
(N-(1-Cyanocyclopropyl)-7-fluoro-3-[(1-methylpyrazo...)
Show SMILES Cn1cc(Cn2c(=O)n(CC3CC3)c3cc(F)c(cc3c2=O)S(=O)(=O)NC2(C)CC2)cn1
Show InChI InChI=1S/C21H24FN5O4S/c1-21(5-6-21)24-32(30,31)18-7-15-17(8-16(18)22)26(11-13-3-4-13)20(29)27(19(15)28)12-14-9-23-25(2)10-14/h7-10,13,24H,3-6,11-12H2,1-2H3
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n/an/a 25n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371293
PNG
(N-(1-Cyanocyclopropyl)-1-[(3-methylisoxazol-5-yl)m...)
Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnc(C)o3)c2=O)S(=O)(=O)NC2(CC2)C#N)on1
Show InChI InChI=1S/C22H20N6O6S/c1-13-7-15(34-25-13)10-27-19-4-3-17(35(31,32)26-22(12-23)5-6-22)8-18(19)20(29)28(21(27)30)11-16-9-24-14(2)33-16/h3-4,7-9,26H,5-6,10-11H2,1-2H3
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n/an/a 27n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371286
PNG
(7-Fluoro-N-(1-methylcyclopropyl)-1,3-bis[(1-methyl...)
Show SMILES Cn1cc(Cn2c3cc(F)c(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(C)CC2)cn1
Show InChI InChI=1S/C22H24FN7O4S/c1-22(4-5-22)26-35(33,34)19-6-16-18(7-17(19)23)29(12-14-8-24-27(2)10-14)21(32)30(20(16)31)13-15-9-25-28(3)11-15/h6-11,26H,4-5,12-13H2,1-3H3
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n/an/a 28n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371382
PNG
(1-[(2,5-Dimethylpyrazol-3-yl)methyl]-3-[(1-methylp...)
Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3ccn(C)c3)c2=O)S(=O)(=O)NC2(C)CC2)n(C)n1
Show InChI InChI=1S/C24H28N6O4S/c1-16-11-18(28(4)25-16)15-29-21-6-5-19(35(33,34)26-24(2)8-9-24)12-20(21)22(31)30(23(29)32)14-17-7-10-27(3)13-17/h5-7,10-13,26H,8-9,14-15H2,1-4H3
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n/an/a 29n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371494
PNG
(1-[(2,5-Dimethylpyrazol-3-yl)methyl]-N-[1-(fluorom...)
Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3nnc(C)s3)c2=O)S(=O)(=O)NC2(CF)CC2)n(C)n1
Show InChI InChI=1S/C22H24FN7O4S2/c1-13-8-15(28(3)26-13)10-29-18-5-4-16(36(33,34)27-22(12-23)6-7-22)9-17(18)20(31)30(21(29)32)11-19-25-24-14(2)35-19/h4-5,8-9,27H,6-7,10-12H2,1-3H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371067
PNG
(US10239843, Example 174)
Show SMILES Cn1cc(Cn2c(=O)n(CC3CC3)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)cn1
Show InChI InChI=1S/C21H25N5O4S/c1-21(7-8-21)23-31(29,30)16-5-6-18-17(9-16)19(27)26(13-15-10-22-24(2)11-15)20(28)25(18)12-14-3-4-14/h5-6,9-11,14,23H,3-4,7-8,12-13H2,1-2H3
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n/an/a 29n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371482
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-1-[(3-methylisothi...)
Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CF)CC2)sn1
Show InChI InChI=1S/C22H23FN6O4S2/c1-14-7-16(34-25-14)12-28-19-4-3-17(35(32,33)26-22(13-23)5-6-22)8-18(19)20(30)29(21(28)31)11-15-9-24-27(2)10-15/h3-4,7-10,26H,5-6,11-13H2,1-2H3
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n/an/a 30n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371481
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-3-[(1-methylpyrazo...)
Show SMILES Cn1cc(Cn2c(=O)n(Cc3cnnc3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
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n/an/a 30n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371292
PNG
(N-(1-Cyanocyclopropyl)-1-(cyclopropylmethyl)-3-[(2...)
Show SMILES Cc1ncc(Cn2c(=O)n(CC3CC3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CC2)C#N)s1
Show InChI InChI=1S/C21H21N5O4S2/c1-13-23-9-15(31-13)11-26-19(27)17-8-16(32(29,30)24-21(12-22)6-7-21)4-5-18(17)25(20(26)28)10-14-2-3-14/h4-5,8-9,14,24H,2-3,6-7,10-11H2,1H3
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n/an/a 31n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371058
PNG
(US10239843, Example 165)
Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3c(=O)n(Cc3c(C)noc3C)c2=O)S(=O)(=O)NC2(C)CC2)s1
Show InChI InChI=1S/C24H27N5O5S2/c1-13-19(15(3)34-26-13)11-29-22(30)18-10-17(36(32,33)27-24(5)8-9-24)6-7-20(18)28(23(29)31)12-21-14(2)25-16(4)35-21/h6-7,10,27H,8-9,11-12H2,1-5H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371439
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-1-[(2-methyloxazol...)
Show SMILES Cc1ncc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CF)CC2)o1
Show InChI InChI=1S/C22H23FN6O5S/c1-14-24-9-16(34-14)12-28-19-4-3-17(35(32,33)26-22(13-23)5-6-22)7-18(19)20(30)29(21(28)31)11-15-8-25-27(2)10-15/h3-4,7-10,26H,5-6,11-13H2,1-2H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371272
PNG
(US10239843, Example 379)
Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(C)CC2)on1
Show InChI InChI=1S/C22H24N6O5S/c1-14-8-16(33-24-14)13-27-19-5-4-17(34(31,32)25-22(2)6-7-22)9-18(19)20(29)28(21(27)30)12-15-10-23-26(3)11-15/h4-5,8-11,25H,6-7,12-13H2,1-3H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371101
PNG
(US10239843, Example 208)
Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cc(C)no3)c2=O)S(=O)(=O)NC2(C)CC2)on1
Show InChI InChI=1S/C22H23N5O6S/c1-13-8-15(32-23-13)11-26-19-5-4-17(34(30,31)25-22(3)6-7-22)10-18(19)20(28)27(21(26)29)12-16-9-14(2)24-33-16/h4-5,8-10,25H,6-7,11-12H2,1-3H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371100
PNG
(US10239843, Example 207 | US10239843, Example 285)
Show SMILES Cc1cc(Cn2c(=O)n(Cc3cc(C)nn3C)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)on1
Show InChI InChI=1S/C23H26N6O5S/c1-14-9-16(27(4)24-14)12-28-20-6-5-18(35(32,33)26-23(3)7-8-23)11-19(20)21(30)29(22(28)31)13-17-10-15(2)25-34-17/h5-6,9-11,26H,7-8,12-13H2,1-4H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371455
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-3-[(1-methylpyrazo...)
Show SMILES Cn1cc(Cn2c(=O)n(Cc3cnco3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Show InChI InChI=1S/C21H21FN6O5S/c1-26-9-14(7-24-26)10-28-19(29)17-6-16(34(31,32)25-21(12-22)4-5-21)2-3-18(17)27(20(28)30)11-15-8-23-13-33-15/h2-3,6-9,13,25H,4-5,10-12H2,1H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371476
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-1-(isoxazol-5-ylme...)
Show SMILES Cn1cc(Cn2c(=O)n(Cc3ccno3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Show InChI InChI=1S/C21H21FN6O5S/c1-26-10-14(9-23-26)11-28-19(29)17-8-16(34(31,32)25-21(13-22)5-6-21)2-3-18(17)27(20(28)30)12-15-4-7-24-33-15/h2-4,7-10,25H,5-6,11-13H2,1H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371507
PNG
(1-Butyl-N-[1-(fluoromethyl)cyclopropyl]-3-[(1-meth...)
Show SMILES CCCCn1c2ccc(cc2c(=O)n(Cc2cnn(C)c2)c1=O)S(=O)(=O)NC1(CF)CC1
Show InChI InChI=1S/C21H26FN5O4S/c1-3-4-9-26-18-6-5-16(32(30,31)24-21(14-22)7-8-21)10-17(18)19(28)27(20(26)29)13-15-11-23-25(2)12-15/h5-6,10-12,24H,3-4,7-9,13-14H2,1-2H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371353
PNG
(1-(Cyclobutylmethyl)-N-[1-(fluoromethyl)cyclopropy...)
Show SMILES Cn1cc(Cn2c(=O)n(CC3CCC3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Show InChI InChI=1S/C22H26FN5O4S/c1-26-11-16(10-24-26)13-28-20(29)18-9-17(33(31,32)25-22(14-23)7-8-22)5-6-19(18)27(21(28)30)12-15-3-2-4-15/h5-6,9-11,15,25H,2-4,7-8,12-14H2,1H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371310
PNG
(1-(Cyclopropylmethyl)-N-[1-(fluoromethyl)cycloprop...)
Show SMILES Cn1cc(Cn2c(=O)n(CC3CC3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Show InChI InChI=1S/C21H24FN5O4S/c1-25-10-15(9-23-25)12-27-19(28)17-8-16(32(30,31)24-21(13-22)6-7-21)4-5-18(17)26(20(27)29)11-14-2-3-14/h4-5,8-10,14,24H,2-3,6-7,11-13H2,1H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371349
PNG
(N-(1-Cyanocyclopropyl)-1-[(1-methylpyrazol-4-yl)me...)
Show SMILES Cc1ncc(Cn2c(=O)n(Cc3cnn(C)c3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CC2)C#N)s1
Show InChI InChI=1S/C22H21N7O4S2/c1-14-24-9-16(34-14)12-29-20(30)18-7-17(35(32,33)26-22(13-23)5-6-22)3-4-19(18)28(21(29)31)11-15-8-25-27(2)10-15/h3-4,7-10,26H,5-6,11-12H2,1-2H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371503
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-1-isopentyl-3-[(1-...)
Show SMILES CC(C)CCn1c2ccc(cc2c(=O)n(Cc2cnn(C)c2)c1=O)S(=O)(=O)NC1(CF)CC1
Show InChI InChI=1S/C22H28FN5O4S/c1-15(2)6-9-27-19-5-4-17(33(31,32)25-22(14-23)7-8-22)10-18(19)20(29)28(21(27)30)13-16-11-24-26(3)12-16/h4-5,10-12,15,25H,6-9,13-14H2,1-3H3
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n/an/a 42n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371467
PNG
(1-[(3-Ethylimidazol-4-yl)methyl]-N-[1-(fluoromethy...)
Show SMILES CCn1cncc1Cn1c2ccc(cc2c(=O)n(Cc2cnn(C)c2)c1=O)S(=O)(=O)NC1(CF)CC1
Show InChI InChI=1S/C23H26FN7O4S/c1-3-29-15-25-10-17(29)13-30-20-5-4-18(36(34,35)27-23(14-24)6-7-23)8-19(20)21(32)31(22(30)33)12-16-9-26-28(2)11-16/h4-5,8-11,15,27H,3,6-7,12-14H2,1-2H3
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n/an/a 42n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371335
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-3-[(1-methylpyrazo...)
Show SMILES Cn1cc(Cn2c(=O)n(CC3CCOCC3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Show InChI InChI=1S/C23H28FN5O5S/c1-27-12-17(11-25-27)14-29-21(30)19-10-18(35(32,33)26-23(15-24)6-7-23)2-3-20(19)28(22(29)31)13-16-4-8-34-9-5-16/h2-3,10-12,16,26H,4-9,13-15H2,1H3
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n/an/a 43n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371252
PNG
(US10239843, Example 359)
Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CC2)C#N)on1
Show InChI InChI=1S/C22H21N7O5S/c1-14-7-16(34-25-14)12-28-19-4-3-17(35(32,33)26-22(13-23)5-6-22)8-18(19)20(30)29(21(28)31)11-15-9-24-27(2)10-15/h3-4,7-10,26H,5-6,11-12H2,1-2H3
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n/an/a 43n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371291
PNG
(7-Fluoro-3-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1...)
Show SMILES Cn1cc(Cn2c(=O)n(CC3(C)COC3)c3cc(F)c(cc3c2=O)S(=O)(=O)NC2(C)CC2)cn1
Show InChI InChI=1S/C22H26FN5O5S/c1-21(12-33-13-21)11-28-17-7-16(23)18(34(31,32)25-22(2)4-5-22)6-15(17)19(29)27(20(28)30)10-14-8-24-26(3)9-14/h6-9,25H,4-5,10-13H2,1-3H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371271
PNG
(US10239843, Example 378)
Show SMILES Cn1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CC2)C#N)cn1
Show InChI InChI=1S/C22H22N8O4S/c1-27-10-15(8-24-27)12-29-19-4-3-17(35(33,34)26-22(14-23)5-6-22)7-18(19)20(31)30(21(29)32)13-16-9-25-28(2)11-16/h3-4,7-11,26H,5-6,12-13H2,1-2H3
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n/an/a 44n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371054
PNG
(US10239843, Example 161)
Show SMILES Cc1ncc(Cn2c(=O)n(CC#C)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)s1
Show InChI InChI=1S/C20H20N4O4S2/c1-4-9-23-17-6-5-15(30(27,28)22-20(3)7-8-20)10-16(17)18(25)24(19(23)26)12-14-11-21-13(2)29-14/h1,5-6,10-11,22H,7-9,12H2,2-3H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371239
PNG
(US10239843, Example 346)
Show SMILES Cn1cc(Cn2c(=O)n(CC3CC3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CC2)C#N)cn1
Show InChI InChI=1S/C21H22N6O4S/c1-25-10-15(9-23-25)12-27-19(28)17-8-16(32(30,31)24-21(13-22)6-7-21)4-5-18(17)26(20(27)29)11-14-2-3-14/h4-5,8-10,14,24H,2-3,6-7,11-12H2,1H3
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CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)

More data for this
Ligand-Target Pair
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