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Patent code US10239876

Compile Data Set for Download or QSAR
Found 170 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371829
PNG
(2-(8-(1H-Indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)Nc1ccccc1
Show InChI InChI=1S/C29H28N6O3/c36-26(31-23-7-3-1-4-8-23)19-34-20-35(24-9-5-2-6-10-24)29(28(34)38)13-15-33(16-14-29)27(37)21-11-12-25-22(17-21)18-30-32-25/h1-12,17-18H,13-16,19-20H2,(H,30,32)(H,31,36)
KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 10.6n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371835
PNG
((rac, trans)-2-(8-(1H-Indazole-5-carbonyl)-4-oxo-1...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1/C32H32N6O3/c39-29(34-28-18-26(28)22-7-3-1-4-8-22)20-37-21-38(25-9-5-2-6-10-25)32(31(37)41)13-15-36(16-14-32)30(40)23-11-12-27-24(17-23)19-33-35-27/h1-12,17,19,26,28H,13-16,18,20-21H2,(H,33,35)(H,34,39)/t26-,28+/s2
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PC sid
UniChem
US Patent
n/an/a 10.9n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372088
PNG
(N-Cyclopropyl-2-[4-oxo-1-phenyl-8-(1H-pyrazolo[3,4...)
Show SMILES FC(F)(F)CN(C1CC1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C27H28F3N7O3/c28-27(29,30)16-36(20-6-7-20)22(38)15-35-17-37(21-4-2-1-3-5-21)26(25(35)40)8-10-34(11-9-26)24(39)19-12-18-14-32-33-23(18)31-13-19/h1-5,12-14,20H,6-11,15-17H2,(H,31,32,33)
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PC sid
UniChem
US Patent
n/an/a 12.4n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371821
PNG
(2-[1-(3-Fluoro-phenyl)-4-oxo-8-(1H-pyrazolo[3,4-b]...)
Show SMILES Fc1cccc(c1)N1CN(CC(=O)NCC(F)(F)F)C(=O)C11CCN(CC1)C(=O)c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C24H23F4N7O3/c25-17-2-1-3-18(9-17)35-14-34(12-19(36)30-13-24(26,27)28)22(38)23(35)4-6-33(7-5-23)21(37)16-8-15-11-31-32-20(15)29-10-16/h1-3,8-11H,4-7,12-14H2,(H,30,36)(H,29,31,32)
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US Patent
n/an/a 12.7n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372102
PNG
(2-(1-(3-Chlorophenyl)-4-oxo-8-(1H-pyrazolo[3,4-b]p...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2cccc(Cl)c2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C24H23ClF3N7O3/c25-17-2-1-3-18(9-17)35-14-34(12-19(36)30-13-24(26,27)28)22(38)23(35)4-6-33(7-5-23)21(37)16-8-15-11-31-32-20(15)29-10-16/h1-3,8-11H,4-7,12-14H2,(H,30,36)(H,29,31,32)
KEGG

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PC sid
UniChem
US Patent
n/an/a 12.9n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371932
PNG
(3-[(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(...)
Show SMILES O=C(N1CCC2(CC1)N(CN(Cc1nc(no1)C1CC1)C2=O)c1ccccc1)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H27N7O3/c35-25(19-8-9-22-20(14-19)15-28-30-22)32-12-10-27(11-13-32)26(36)33(17-34(27)21-4-2-1-3-5-21)16-23-29-24(31-37-23)18-6-7-18/h1-5,8-9,14-15,18H,6-7,10-13,16-17H2,(H,28,30)
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US Patent
n/an/a 13.8n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371847
PNG
(2-(8-(1H-Indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)Nc1ccccn1
Show InChI InChI=1S/C28H27N7O3/c36-25(31-24-8-4-5-13-29-24)18-34-19-35(22-6-2-1-3-7-22)28(27(34)38)11-14-33(15-12-28)26(37)20-9-10-23-21(16-20)17-30-32-23/h1-10,13,16-17H,11-12,14-15,18-19H2,(H,30,32)(H,29,31,36)
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PC sid
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US Patent
n/an/a 15.4n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371830
PNG
(2-(8-(1H-Indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C25H25F3N6O3/c26-25(27,28)15-29-21(35)14-33-16-34(19-4-2-1-3-5-19)24(23(33)37)8-10-32(11-9-24)22(36)17-6-7-20-18(12-17)13-30-31-20/h1-7,12-13H,8-11,14-16H2,(H,29,35)(H,30,31)
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n/an/a 15.5n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372136
PNG
(2-[8-(1H-indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Show SMILES FC(F)(F)C1(CC1)NC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C27H27F3N6O3/c28-27(29,30)26(8-9-26)32-22(37)16-35-17-36(20-4-2-1-3-5-20)25(24(35)39)10-12-34(13-11-25)23(38)18-6-7-21-19(14-18)15-31-33-21/h1-7,14-15H,8-13,16-17H2,(H,31,33)(H,32,37)
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PC sid
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US Patent
n/an/a 17.2n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372052
PNG
(2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...)
Show SMILES CC(C)N(CC(F)(F)F)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C27H30F3N7O3/c1-18(2)36(16-27(28,29)30)22(38)15-35-17-37(21-6-4-3-5-7-21)26(25(35)40)8-10-34(11-9-26)24(39)20-12-19-14-32-33-23(19)31-13-20/h3-7,12-14,18H,8-11,15-17H2,1-2H3,(H,31,32,33)
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US Patent
n/an/a 17.2n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371865
PNG
(2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C24H24F3N7O3/c25-24(26,27)14-29-19(35)13-33-15-34(18-4-2-1-3-5-18)23(22(33)37)6-8-32(9-7-23)21(36)17-10-16-12-30-31-20(16)28-11-17/h1-5,10-12H,6-9,13-15H2,(H,29,35)(H,28,30,31)
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US Patent
n/an/a 17.3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372092
PNG
((S)-3-(2-Oxo-2-(2-(trifluoromethyl)pyrrolidin-1-yl...)
Show SMILES FC(F)(F)C1CCCN1C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C27H28F3N7O3/c28-27(29,30)21-7-4-10-36(21)22(38)16-35-17-37(20-5-2-1-3-6-20)26(25(35)40)8-11-34(12-9-26)24(39)19-13-18-15-32-33-23(18)31-14-19/h1-3,5-6,13-15,21H,4,7-12,16-17H2,(H,31,32,33)
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n/an/a 17.7n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372117
PNG
((R)- or (S)-3-(2-Oxo-2-(2-(trifluoromethyl)morphol...)
Show SMILES FC(F)(F)[C@H]1CN(CCO1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3n2)C1=O
Show InChI InChI=1/C27H28F3N7O4/c28-27(29,30)22-15-35(12-13-41-22)23(38)16-36-17-37(18-4-2-1-3-5-18)26(25(36)40)8-10-34(11-9-26)24(39)20-7-6-19-21(32-20)14-31-33-19/h1-7,14,22H,8-13,15-17H2,(H,31,33)/t22-/s2
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n/an/a 17.7n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372139
PNG
(2-(8-(7-Methyl-1H-indazole-5-carbonyl)-4-oxo-1-phe...)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)N(CN(CC(=O)NCC(F)(F)F)C2=O)c1ccccc1
Show InChI InChI=1S/C26H27F3N6O3/c1-17-11-18(12-19-13-31-32-22(17)19)23(37)33-9-7-25(8-10-33)24(38)34(14-21(36)30-15-26(27,28)29)16-35(25)20-5-3-2-4-6-20/h2-6,11-13H,7-10,14-16H2,1H3,(H,30,36)(H,31,32)
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US Patent
n/an/a 17.8n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372125
PNG
((S)- or (R)-8-(1H-indazole-5-carbonyl)-3-(2-oxo-2-...)
Show SMILES FC(F)(F)[C@H]1CN(CCO1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C28H29F3N6O4/c29-28(30,31)23-16-35(12-13-41-23)24(38)17-36-18-37(21-4-2-1-3-5-21)27(26(36)40)8-10-34(11-9-27)25(39)19-6-7-22-20(14-19)15-32-33-22/h1-7,14-15,23H,8-13,16-18H2,(H,32,33)/t23-/s2
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n/an/a 18.1n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372078
PNG
(2-(8-(1H-Indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Show SMILES CN(CC(F)(F)F)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C26H27F3N6O3/c1-32(16-26(27,28)29)22(36)15-34-17-35(20-5-3-2-4-6-20)25(24(34)38)9-11-33(12-10-25)23(37)18-7-8-21-19(13-18)14-30-31-21/h2-8,13-14H,9-12,15-17H2,1H3,(H,30,31)
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n/an/a 18.7n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372045
PNG
(3-[2-(3,3-Difluoropyrrolidin-1-yl)-2-oxoethyl]-1-p...)
Show SMILES FC1(F)CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C26H27F2N7O3/c27-26(28)8-11-33(16-26)21(36)15-34-17-35(20-4-2-1-3-5-20)25(24(34)38)6-9-32(10-7-25)23(37)19-12-18-14-30-31-22(18)29-13-19/h1-5,12-14H,6-11,15-17H2,(H,29,30,31)
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n/an/a 19.1n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372046
PNG
((RS)-3-[2-(2,2-Difluoro-5-azaspiro[2.4]heptan-5-yl...)
Show SMILES FC1(F)CC11CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C28H29F2N7O3/c29-28(30)16-26(28)6-9-35(17-26)22(38)15-36-18-37(21-4-2-1-3-5-21)27(25(36)40)7-10-34(11-8-27)24(39)20-12-19-14-32-33-23(19)31-13-20/h1-5,12-14H,6-11,15-18H2,(H,31,32,33)
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US Patent
n/an/a 19.3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372110
PNG
(8-(1H-Indazole-5-carbonyl)-3-[2-[4-methyl-3-(trifl...)
Show SMILES CN1CCN(CC1C(F)(F)F)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C29H32F3N7O3/c1-35-13-14-37(17-24(35)29(30,31)32)25(40)18-38-19-39(22-5-3-2-4-6-22)28(27(38)42)9-11-36(12-10-28)26(41)20-7-8-23-21(15-20)16-33-34-23/h2-8,15-16,24H,9-14,17-19H2,1H3,(H,33,34)
KEGG

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n/an/a 19.3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372068
PNG
(2-(4-Oxo-1-phenyl-8-(1H-pyrazolo[4,3-b]pyridine-5-...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3n2)C1=O
Show InChI InChI=1S/C24H24F3N7O3/c25-24(26,27)14-28-20(35)13-33-15-34(16-4-2-1-3-5-16)23(22(33)37)8-10-32(11-9-23)21(36)18-7-6-17-19(30-18)12-29-31-17/h1-7,12H,8-11,13-15H2,(H,28,35)(H,29,31)
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n/an/a 19.4n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371875
PNG
(2-(4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)Nc1ccccc1
Show InChI InChI=1S/C28H27N7O3/c36-24(31-22-7-3-1-4-8-22)18-34-19-35(23-9-5-2-6-10-23)28(27(34)38)11-13-33(14-12-28)26(37)21-15-20-17-30-32-25(20)29-16-21/h1-10,15-17H,11-14,18-19H2,(H,31,36)(H,29,30,32)
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n/an/a 19.7n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372081
PNG
(2-(8-(3-Amino-1H-indazole-5-carbonyl)-4-oxo-1-phen...)
Show SMILES Nc1n[nH]c2ccc(cc12)C(=O)N1CCC2(CC1)N(CN(CC(=O)NCC(F)(F)F)C2=O)c1ccccc1
Show InChI InChI=1S/C25H26F3N7O3/c26-25(27,28)14-30-20(36)13-34-15-35(17-4-2-1-3-5-17)24(23(34)38)8-10-33(11-9-24)22(37)16-6-7-19-18(12-16)21(29)32-31-19/h1-7,12H,8-11,13-15H2,(H,30,36)(H3,29,31,32)
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n/an/a 21n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372090
PNG
((−)-2-[8-(1H-Indazole-5-carbonyl)-4-oxo-1-ph...)
Show SMILES C[C@@H](N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)C(=O)NCC(F)(F)F
Show InChI InChI=1/C26H27F3N6O3/c1-17(22(36)30-15-26(27,28)29)34-16-35(20-5-3-2-4-6-20)25(24(34)38)9-11-33(12-10-25)23(37)18-7-8-21-19(13-18)14-31-32-21/h2-8,13-14,17H,9-12,15-16H2,1H3,(H,30,36)(H,31,32)/t17-/s2
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n/an/a 22n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372114
PNG
(N-(2-(Morpholinomethyl)phenyl)-2-(4-oxo-1-phenyl-8...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)Nc1ccccc1CN1CCOCC1
Show InChI InChI=1S/C33H36N8O4/c42-29(36-28-9-5-4-6-24(28)21-38-14-16-45-17-15-38)22-40-23-41(27-7-2-1-3-8-27)33(32(40)44)10-12-39(13-11-33)31(43)26-18-25-20-35-37-30(25)34-19-26/h1-9,18-20H,10-17,21-23H2,(H,36,42)(H,34,35,37)
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n/an/a 23.1n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372120
PNG
((R)- or (S)-8-(1H-indazole-5-carbonyl)-3-(2-oxo-2-...)
Show SMILES FC(F)(F)[C@@H]1CN(CCO1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C28H29F3N6O4/c29-28(30,31)23-16-35(12-13-41-23)24(38)17-36-18-37(21-4-2-1-3-5-21)27(26(36)40)8-10-34(11-9-27)25(39)19-6-7-22-20(14-19)15-32-33-22/h1-7,14-15,23H,8-13,16-18H2,(H,32,33)/t23-/s2
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n/an/a 23.3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371983
PNG
((RS)-3-[2-Oxo-2-[3-(trifluoromethyl)pyrrolidin-1-y...)
Show SMILES FC(F)(F)C1CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C27H28F3N7O3/c28-27(29,30)20-6-9-35(15-20)22(38)16-36-17-37(21-4-2-1-3-5-21)26(25(36)40)7-10-34(11-8-26)24(39)19-12-18-14-32-33-23(18)31-13-19/h1-5,12-14,20H,6-11,15-17H2,(H,31,32,33)
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n/an/a 23.8n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371993
PNG
(3-[2-(3,3-Dimethylpyrrolidin-1-yl)-2-oxoethyl]-8-(...)
Show SMILES CC1(C)CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C29H34N6O3/c1-28(2)10-13-33(19-28)25(36)18-34-20-35(23-6-4-3-5-7-23)29(27(34)38)11-14-32(15-12-29)26(37)21-8-9-24-22(16-21)17-30-31-24/h3-9,16-17H,10-15,18-20H2,1-2H3,(H,30,31)
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n/an/a 24.4n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372080
PNG
(2-(8-(3-Methyl-1H-indazole-5-carbonyl)-4-oxo-1-phe...)
Show SMILES Cc1n[nH]c2ccc(cc12)C(=O)N1CCC2(CC1)N(CN(CC(=O)NCC(F)(F)F)C2=O)c1ccccc1
Show InChI InChI=1S/C26H27F3N6O3/c1-17-20-13-18(7-8-21(20)32-31-17)23(37)33-11-9-25(10-12-33)24(38)34(14-22(36)30-15-26(27,28)29)16-35(25)19-5-3-2-4-6-19/h2-8,13H,9-12,14-16H2,1H3,(H,30,36)(H,31,32)
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n/an/a 25n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371921
PNG
(N-(Adamantan-1-yl)-2-(4-oxo-1-phenyl-8-(1H-pyrazol...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C32H37N7O3/c40-27(35-31-14-21-10-22(15-31)12-23(11-21)16-31)19-38-20-39(26-4-2-1-3-5-26)32(30(38)42)6-8-37(9-7-32)29(41)25-13-24-18-34-36-28(24)33-17-25/h1-5,13,17-18,21-23H,6-12,14-16,19-20H2,(H,35,40)(H,33,34,36)
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n/an/a 27.1n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372044
PNG
((RS)-3-[2-(3-Fluoro-3-methylpyrrolidin-1-yl)-2-oxo...)
Show SMILES CC1(F)CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C27H30FN7O3/c1-26(28)7-10-33(17-26)22(36)16-34-18-35(21-5-3-2-4-6-21)27(25(34)38)8-11-32(12-9-27)24(37)20-13-19-15-30-31-23(19)29-14-20/h2-6,13-15H,7-12,16-18H2,1H3,(H,29,30,31)
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n/an/a 27.3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372122
PNG
((S)- or (R)-3-(2-Oxo-2-(2-(trifluoromethyl)morphol...)
Show SMILES FC(F)(F)[C@@H]1CN(CCO1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3n2)C1=O
Show InChI InChI=1/C27H28F3N7O4/c28-27(29,30)22-15-35(12-13-41-22)23(38)16-36-17-37(18-4-2-1-3-5-18)26(25(36)40)8-10-34(11-9-26)24(39)20-7-6-19-21(32-20)14-31-33-19/h1-7,14,22H,8-13,15-17H2,(H,31,33)/t22-/s2
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n/an/a 27.9n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372129
PNG
(8-(1H-Indazole-5-carbonyl)-3-[2-[(3S or 3R)-4-meth...)
Show SMILES CN1CCN(C[C@H]1C(F)(F)F)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C29H32F3N7O3/c1-35-13-14-37(17-24(35)29(30,31)32)25(40)18-38-19-39(22-5-3-2-4-6-22)28(27(38)42)9-11-36(12-10-28)26(41)20-7-8-23-21(15-20)16-33-34-23/h2-8,15-16,24H,9-14,17-19H2,1H3,(H,33,34)/t24-/s2
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n/an/a 29.5n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371909
PNG
(N-Methyl-2-(4-oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]py...)
Show SMILES CN(CC(F)(F)F)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C25H26F3N7O3/c1-32(15-25(26,27)28)20(36)14-34-16-35(19-5-3-2-4-6-19)24(23(34)38)7-9-33(10-8-24)22(37)18-11-17-13-30-31-21(17)29-12-18/h2-6,11-13H,7-10,14-16H2,1H3,(H,29,30,31)
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n/an/a 29.6n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372137
PNG
(N-(2-cyanopropan-2-yl)-2-[8-(1H-indazole-5-carbony...)
Show SMILES CC(C)(NC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)C#N
Show InChI InChI=1S/C27H29N7O3/c1-26(2,17-28)30-23(35)16-33-18-34(21-6-4-3-5-7-21)27(25(33)37)10-12-32(13-11-27)24(36)19-8-9-22-20(14-19)15-29-31-22/h3-9,14-15H,10-13,16,18H2,1-2H3,(H,29,31)(H,30,35)
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n/an/a 33.2n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372085
PNG
(N-(6-Cyanopyridin-2-yl)-2-[4-oxo-1-phenyl-8-(1H-py...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)Nc1cccc(n1)C#N
Show InChI InChI=1S/C28H25N9O3/c29-14-21-5-4-8-23(32-21)33-24(38)17-36-18-37(22-6-2-1-3-7-22)28(27(36)40)9-11-35(12-10-28)26(39)20-13-19-16-31-34-25(19)30-15-20/h1-8,13,15-16H,9-12,17-18H2,(H,30,31,34)(H,32,33,38)
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n/an/a 33.3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372119
PNG
((R)- or (S)-8-(1H-Indazole-5-carbonyl)-3-(2-oxo-2-...)
Show SMILES FC(F)(F)[C@H]1CN(CCO1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C27H28F3N7O4/c28-27(29,30)21-15-35(10-11-41-21)22(38)16-36-17-37(20-4-2-1-3-5-20)26(25(36)40)6-8-34(9-7-26)24(39)19-12-18-14-32-33-23(18)31-13-19/h1-5,12-14,21H,6-11,15-17H2,(H,31,32,33)/t21-/s2
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n/an/a 33.7n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372101
PNG
(3-(2-Oxo-2-(2-(trifluoromethyl)morpholino)ethyl)-1...)
Show SMILES FC(F)(F)C1CN(CCO1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C27H28F3N7O4/c28-27(29,30)21-15-35(10-11-41-21)22(38)16-36-17-37(20-4-2-1-3-5-20)26(25(36)40)6-8-34(9-7-26)24(39)19-12-18-14-32-33-23(18)31-13-19/h1-5,12-14,21H,6-11,15-17H2,(H,31,32,33)
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n/an/a 34.3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372082
PNG
(2-[8-(1H-Indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Show SMILES CC(N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)C(=O)NCC(F)(F)F
Show InChI InChI=1/C26H27F3N6O3/c1-17(22(36)30-15-26(27,28)29)34-16-35(20-5-3-2-4-6-20)25(24(34)38)9-11-33(12-10-25)23(37)18-7-8-21-19(13-18)14-31-32-21/h2-8,13-14,17H,9-12,15-16H2,1H3,(H,30,36)(H,31,32)
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n/an/a 34.9n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372133
PNG
(N-(2-hydroxyethyl)-2-[8-(1H-indazole-5-carbonyl)-4...)
Show SMILES OCCN(CC(F)(F)F)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C27H29F3N6O4/c28-27(29,30)17-34(12-13-37)23(38)16-35-18-36(21-4-2-1-3-5-21)26(25(35)40)8-10-33(11-9-26)24(39)19-6-7-22-20(14-19)15-31-32-22/h1-7,14-15,37H,8-13,16-18H2,(H,31,32)
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n/an/a 36.3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372146
PNG
(2-[1-(3-Chloro-5-fluorophenyl)-4-oxo-8-(1H-pyrazol...)
Show SMILES Fc1cc(Cl)cc(c1)N1CN(CC(=O)NCC(F)(F)F)C(=O)C11CCN(CC1)C(=O)c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C24H22ClF4N7O3/c25-16-6-17(26)8-18(7-16)36-13-35(11-19(37)31-12-24(27,28)29)22(39)23(36)1-3-34(4-2-23)21(38)15-5-14-10-32-33-20(14)30-9-15/h5-10H,1-4,11-13H2,(H,31,37)(H,30,32,33)
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n/an/a 36.9n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371833
PNG
(2-(8-(1H-Indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)NCCN1CCOCC1
Show InChI InChI=1S/C29H35N7O4/c37-26(30-10-13-33-14-16-40-17-15-33)20-35-21-36(24-4-2-1-3-5-24)29(28(35)39)8-11-34(12-9-29)27(38)22-6-7-25-23(18-22)19-31-32-25/h1-7,18-19H,8-17,20-21H2,(H,30,37)(H,31,32)
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n/an/a 39.7n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372130
PNG
((R) or (S)-8-(1H-indazole-5-carbonyl)-3-(2-oxo-2-(...)
Show SMILES FC(F)(F)[C@H]1CN(CCN1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C28H30F3N7O3/c29-28(30,31)23-16-36(13-10-32-23)24(39)17-37-18-38(21-4-2-1-3-5-21)27(26(37)41)8-11-35(12-9-27)25(40)19-6-7-22-20(14-19)15-33-34-22/h1-7,14-15,23,32H,8-13,16-18H2,(H,33,34)/t23-/s2
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n/an/a 41.9n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371836
PNG
(8-(1H-Indazole-5-carbonyl)-3-(2-morpholino-2-oxoet...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)N1CCOCC1
Show InChI InChI=1S/C27H30N6O4/c34-24(30-12-14-37-15-13-30)18-32-19-33(22-4-2-1-3-5-22)27(26(32)36)8-10-31(11-9-27)25(35)20-6-7-23-21(16-20)17-28-29-23/h1-7,16-17H,8-15,18-19H2,(H,28,29)
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n/an/a 43n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372067
PNG
(2-(3-((2-(8-(1H-indazole-5-carbonyl)-4-oxo-1-pheny...)
Show SMILES CNC(=O)Cc1cccc(CNC(=O)CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3ccc4[nH]ncc4c3)C2=O)c1
Show InChI InChI=1S/C33H35N7O4/c1-34-29(41)17-23-6-5-7-24(16-23)19-35-30(42)21-39-22-40(27-8-3-2-4-9-27)33(32(39)44)12-14-38(15-13-33)31(43)25-10-11-28-26(18-25)20-36-37-28/h2-11,16,18,20H,12-15,17,19,21-22H2,1H3,(H,34,41)(H,35,42)(H,36,37)
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n/an/a 43.1n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371856
PNG
(2-(4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-c]pyridine-5-...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cc3cn[nH]c3cn2)C1=O
Show InChI InChI=1S/C24H24F3N7O3/c25-24(26,27)14-29-20(35)13-33-15-34(17-4-2-1-3-5-17)23(22(33)37)6-8-32(9-7-23)21(36)18-10-16-11-30-31-19(16)12-28-18/h1-5,10-12H,6-9,13-15H2,(H,29,35)(H,30,31)
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n/an/a 43.7n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372100
PNG
(N-(2-(2-((4-methylpiperazin-1-yl)methyl)phenyl)cyc...)
Show SMILES CN1CCN(Cc2ccccc2C2CC2NC(=O)CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3cnc4[nH]ncc4c3)C2=O)CC1
Show InChI InChI=1/C37H43N9O3/c1-42-15-17-43(18-16-42)23-26-7-5-6-10-30(26)31-20-32(31)40-33(47)24-45-25-46(29-8-3-2-4-9-29)37(36(45)49)11-13-44(14-12-37)35(48)28-19-27-22-39-41-34(27)38-21-28/h2-10,19,21-22,31-32H,11-18,20,23-25H2,1H3,(H,40,47)(H,38,39,41)
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n/an/a 45.6n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372131
PNG
((S)- or (R)-8-(1H-indazole-5-carbonyl)-3-(2-oxo-2-...)
Show SMILES FC(F)(F)[C@@H]1CN(CCN1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C28H30F3N7O3/c29-28(30,31)23-16-36(13-10-32-23)24(39)17-37-18-38(21-4-2-1-3-5-21)27(26(37)41)8-11-35(12-9-27)25(40)19-6-7-22-20(14-19)15-33-34-22/h1-7,14-15,23,32H,8-13,16-18H2,(H,33,34)/t23-/s2
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n/an/a 46.7n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371880
PNG
(2-(4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)Nc1ccccn1
Show InChI InChI=1S/C27H26N8O3/c36-23(31-22-8-4-5-11-28-22)17-34-18-35(21-6-2-1-3-7-21)27(26(34)38)9-12-33(13-10-27)25(37)20-14-19-16-30-32-24(19)29-15-20/h1-8,11,14-16H,9-10,12-13,17-18H2,(H,28,31,36)(H,29,30,32)
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n/an/a 49.4n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371857
PNG
(2-(8-(Imidazo[1,5-a]pyridine-6-carbonyl)-4-oxo-1-p...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cn3cncc3cn2)C1=O
Show InChI InChI=1S/C24H24F3N7O3/c25-24(26,27)14-30-20(35)13-33-16-34(17-4-2-1-3-5-17)23(22(33)37)6-8-31(9-7-23)21(36)19-12-32-15-28-10-18(32)11-29-19/h1-5,10-12,15H,6-9,13-14,16H2,(H,30,35)
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n/an/a 54.6n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371966
PNG
((RS)-2-[8-(1H-Indazole-5-carbonyl)-2-methyl-4-oxo-...)
Show SMILES CC1N(CC(=O)NCC(F)(F)F)C(=O)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)N1c1ccccc1
Show InChI InChI=1/C26H27F3N6O3/c1-17-34(15-22(36)30-16-26(27,28)29)24(38)25(35(17)20-5-3-2-4-6-20)9-11-33(12-10-25)23(37)18-7-8-21-19(13-18)14-31-32-21/h2-8,13-14,17H,9-12,15-16H2,1H3,(H,30,36)(H,31,32)
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n/an/a 54.7n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372019
PNG
((RS)-3-(2-Oxo-1-phenylpyrrolidin-3-yl)-1-phenyl-8-...)
Show SMILES O=C(N1CCC2(CC1)N(CN(C1CCN(C1=O)c1ccccc1)C2=O)c1ccccc1)c1cnc2[nH]ncc2c1
Show InChI InChI=1/C30H29N7O3/c38-27(22-17-21-19-32-33-26(21)31-18-22)34-15-12-30(13-16-34)29(40)36(20-37(30)24-9-5-2-6-10-24)25-11-14-35(28(25)39)23-7-3-1-4-8-23/h1-10,17-19,25H,11-16,20H2,(H,31,32,33)
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n/an/a 59.5n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372140
PNG
(2-[1-(3-Bromophenyl)-4-oxo-8-(1H-pyrazolo[3,4-b]py...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2cccc(Br)c2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C24H23BrF3N7O3/c25-17-2-1-3-18(9-17)35-14-34(12-19(36)30-13-24(26,27)28)22(38)23(35)4-6-33(7-5-23)21(37)16-8-15-11-31-32-20(15)29-10-16/h1-3,8-11H,4-7,12-14H2,(H,30,36)(H,29,31,32)
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n/an/a 59.9n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372111
PNG
(2-(4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...)
Show SMILES FC(F)(F)c1cccc(NC(=O)CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3cnc4[nH]ncc4c3)C2=O)n1
Show InChI InChI=1S/C28H25F3N8O3/c29-28(30,31)21-7-4-8-22(34-21)35-23(40)16-38-17-39(20-5-2-1-3-6-20)27(26(38)42)9-11-37(12-10-27)25(41)19-13-18-15-33-36-24(18)32-14-19/h1-8,13-15H,9-12,16-17H2,(H,32,33,36)(H,34,35,40)
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n/an/a 63.1n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371950
PNG
(3-[(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)methyl]-8-...)
Show SMILES O=C(N1CCC2(CC1)N(CN(Cc1nnc(s1)C1CC1)C2=O)c1ccccc1)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H27N7O2S/c35-25(19-8-9-22-20(14-19)15-28-29-22)32-12-10-27(11-13-32)26(36)33(17-34(27)21-4-2-1-3-5-21)16-23-30-31-24(37-23)18-6-7-18/h1-5,8-9,14-15,18H,6-7,10-13,16-17H2,(H,28,29)
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n/an/a 64.1n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372071
PNG
(N-(2,2-Difluoroethyl)-2-[4-oxo-1-phenyl-8-(1H-pyra...)
Show SMILES FC(F)CNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C24H25F2N7O3/c25-19(26)13-27-20(34)14-32-15-33(18-4-2-1-3-5-18)24(23(32)36)6-8-31(9-7-24)22(35)17-10-16-12-29-30-21(16)28-11-17/h1-5,10-12,19H,6-9,13-15H2,(H,27,34)(H,28,29,30)
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n/an/a 65.4n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372025
PNG
(3-[2-[(3R)-3-Fluoropyrrolidin-1-yl]-2-oxoethyl]-1-...)
Show SMILES F[C@@H]1CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C26H28FN7O3/c27-20-6-9-32(15-20)22(35)16-33-17-34(21-4-2-1-3-5-21)26(25(33)37)7-10-31(11-8-26)24(36)19-12-18-14-29-30-23(18)28-13-19/h1-5,12-14,20H,6-11,15-17H2,(H,28,29,30)/t20-/s2
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n/an/a 65.8n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372109
PNG
(3-[2-[4-Methyl-3-(trifluoromethyl)piperazin-1-yl]-...)
Show SMILES CN1CCN(CC1C(F)(F)F)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C28H31F3N8O3/c1-35-11-12-37(16-22(35)28(29,30)31)23(40)17-38-18-39(21-5-3-2-4-6-21)27(26(38)42)7-9-36(10-8-27)25(41)20-13-19-15-33-34-24(19)32-14-20/h2-6,13-15,22H,7-12,16-18H2,1H3,(H,32,33,34)
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n/an/a 69.5n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372132
PNG
(N-[2-(dimethylamino)ethyl]-2-[8-(1H-indazole-5-car...)
Show SMILES CN(C)CCN(CC(F)(F)F)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C29H34F3N7O3/c1-35(2)14-15-37(19-29(30,31)32)25(40)18-38-20-39(23-6-4-3-5-7-23)28(27(38)42)10-12-36(13-11-28)26(41)21-8-9-24-22(16-21)17-33-34-24/h3-9,16-17H,10-15,18-20H2,1-2H3,(H,33,34)
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n/an/a 75.3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372097
PNG
(N-(5-cyano-1,3-thiazol-2-yl)-2-[4-oxo-1-phenyl-8-(...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)Nc1ncc(s1)C#N
Show InChI InChI=1S/C26H23N9O3S/c27-11-20-14-29-25(39-20)31-21(36)15-34-16-35(19-4-2-1-3-5-19)26(24(34)38)6-8-33(9-7-26)23(37)18-10-17-13-30-32-22(17)28-12-18/h1-5,10,12-14H,6-9,15-16H2,(H,28,30,32)(H,29,31,36)
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n/an/a 80n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372083
PNG
(3-[(+)-2-Oxo-1-(2,2,2-trifluoroethyl)pyrrolidin-3-...)
Show SMILES FC(F)(F)CN1CC[C@@H](N2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3cnc4[nH]ncc4c3)C2=O)C1=O
Show InChI InChI=1/C26H26F3N7O3/c27-26(28,29)15-34-9-6-20(23(34)38)35-16-36(19-4-2-1-3-5-19)25(24(35)39)7-10-33(11-8-25)22(37)18-12-17-14-31-32-21(17)30-13-18/h1-5,12-14,20H,6-11,15-16H2,(H,30,31,32)/t20-/s2
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n/an/a 80.7n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371989
PNG
((RS)-1-[2-[8-(1H-Indazole-5-carbonyl)-4-oxo-1-phen...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)N1CCC(C1)C#N
Show InChI InChI=1/C28H29N7O3/c29-15-20-8-11-33(17-20)25(36)18-34-19-35(23-4-2-1-3-5-23)28(27(34)38)9-12-32(13-10-28)26(37)21-6-7-24-22(14-21)16-30-31-24/h1-7,14,16,20H,8-13,17-19H2,(H,30,31)
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n/an/a 80.7n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371852
PNG
(2-[8-(3-Amino-1H-indazole-6-carbonyl)-4-oxo-1-phen...)
Show SMILES Nc1n[nH]c2cc(ccc12)C(=O)N1CCC2(CC1)N(CN(CC(=O)NCC(F)(F)F)C2=O)c1ccccc1
Show InChI InChI=1S/C25H26F3N7O3/c26-25(27,28)14-30-20(36)13-34-15-35(17-4-2-1-3-5-17)24(23(34)38)8-10-33(11-9-24)22(37)16-6-7-18-19(12-16)31-32-21(18)29/h1-7,12H,8-11,13-15H2,(H,30,36)(H3,29,31,32)
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n/an/a 83.3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372143
PNG
(8-(1H-Indazole-5-carbonyl)-3-[2-[4-methyl-2-(trifl...)
Show SMILES CN1CCN(C(C1)C(F)(F)F)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C29H32F3N7O3/c1-35-13-14-38(24(17-35)29(30,31)32)25(40)18-37-19-39(22-5-3-2-4-6-22)28(27(37)42)9-11-36(12-10-28)26(41)20-7-8-23-21(15-20)16-33-34-23/h2-8,15-16,24H,9-14,17-19H2,1H3,(H,33,34)
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n/an/a 83.5n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372054
PNG
((RS)-3-[2-Oxo-1-(2,2,2-trifluoroethyl)pyrrolidin-3...)
Show SMILES FC(F)(F)CN1CCC(N2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3cnc4[nH]ncc4c3)C2=O)C1=O
Show InChI InChI=1/C26H26F3N7O3/c27-26(28,29)15-34-9-6-20(23(34)38)35-16-36(19-4-2-1-3-5-19)25(24(35)39)7-10-33(11-8-25)22(37)18-12-17-14-31-32-21(17)30-13-18/h1-5,12-14,20H,6-11,15-16H2,(H,30,31,32)
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n/an/a 87.7n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372124
PNG
((S)- or (R)-3-(2-Oxo-2-(2-(trifluoromethyl)morphol...)
Show SMILES FC(F)(F)[C@H]1CN(CCO1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cc3cn[nH]c3cn2)C1=O
Show InChI InChI=1/C27H28F3N7O4/c28-27(29,30)22-15-35(10-11-41-22)23(38)16-36-17-37(19-4-2-1-3-5-19)26(25(36)40)6-8-34(9-7-26)24(39)20-12-18-13-32-33-21(18)14-31-20/h1-5,12-14,22H,6-11,15-17H2,(H,32,33)/t22-/s2
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n/an/a 96n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372098
PNG
(N-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]-2-[4-...)
Show SMILES Cn1nc(cc1NC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)C(F)(F)F
Show InChI InChI=1S/C27H26F3N9O3/c1-36-21(12-20(35-36)27(28,29)30)33-22(40)15-38-16-39(19-5-3-2-4-6-19)26(25(38)42)7-9-37(10-8-26)24(41)18-11-17-14-32-34-23(17)31-13-18/h2-6,11-14H,7-10,15-16H2,1H3,(H,33,40)(H,31,32,34)
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n/an/a 103n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372144
PNG
((S)-Methyl 4,4-difluoro-1-(2-(4-oxo-1-phenyl-8-(1H...)
Show SMILES COC(=O)[C@@H]1CC(F)(F)CN1C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C28H29F2N7O5/c1-42-25(40)21-12-28(29,30)16-36(21)22(38)15-35-17-37(20-5-3-2-4-6-20)27(26(35)41)7-9-34(10-8-27)24(39)19-11-18-14-32-33-23(18)31-13-19/h2-6,11,13-14,21H,7-10,12,15-17H2,1H3,(H,31,32,33)/t21-/s2
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n/an/a 106n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372128
PNG
(8-(1H-indazole-5-carbonyl)-3-[2-[(3R or 3S)-4-meth...)
Show SMILES CN1CCN(C[C@@H]1C(F)(F)F)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C29H32F3N7O3/c1-35-13-14-37(17-24(35)29(30,31)32)25(40)18-38-19-39(22-5-3-2-4-6-22)28(27(38)42)9-11-36(12-10-28)26(41)20-7-8-23-21(15-20)16-33-34-23/h2-8,15-16,24H,9-14,17-19H2,1H3,(H,33,34)/t24-/s2
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n/an/a 110n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372121
PNG
((S)- or (R)-3-(2-Oxo-2-(2-(trifluoromethyl)morphol...)
Show SMILES FC(F)(F)[C@@H]1CN(CCO1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C27H28F3N7O4/c28-27(29,30)21-15-35(10-11-41-21)22(38)16-36-17-37(20-4-2-1-3-5-20)26(25(36)40)6-8-34(9-7-26)24(39)19-12-18-14-32-33-23(18)31-13-19/h1-5,12-14,21H,6-11,15-17H2,(H,31,32,33)/t21-/s2
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n/an/a 110n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372079
PNG
(N-Methyl-2-(4-oxo-1-phenyl-8-(1H-pyrazolo[3,4-c]py...)
Show SMILES CN(CC(F)(F)F)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cc3cn[nH]c3cn2)C1=O
Show InChI InChI=1S/C25H26F3N7O3/c1-32(15-25(26,27)28)21(36)14-34-16-35(18-5-3-2-4-6-18)24(23(34)38)7-9-33(10-8-24)22(37)19-11-17-12-30-31-20(17)13-29-19/h2-6,11-13H,7-10,14-16H2,1H3,(H,30,31)
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n/an/a 111n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371936
PNG
(8-(1H-Indazole-5-carbonyl)-3-[(2-methyl-1,3-thiazo...)
Show SMILES Cc1nc(CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3ccc4[nH]ncc4c3)C2=O)cs1
Show InChI InChI=1S/C26H26N6O2S/c1-18-28-21(16-35-18)15-31-17-32(22-5-3-2-4-6-22)26(25(31)34)9-11-30(12-10-26)24(33)19-7-8-23-20(13-19)14-27-29-23/h2-8,13-14,16H,9-12,15,17H2,1H3,(H,27,29)
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n/an/a 114n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372123
PNG
((R)- or (S)-3-(2-Oxo-2-(2-(trifluoromethyl)morphol...)
Show SMILES FC(F)(F)[C@@H]1CN(CCO1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cc3cn[nH]c3cn2)C1=O
Show InChI InChI=1/C27H28F3N7O4/c28-27(29,30)22-15-35(10-11-41-22)23(38)16-36-17-37(19-4-2-1-3-5-19)26(25(36)40)6-8-34(9-7-26)24(39)20-12-18-13-32-33-21(18)14-31-20/h1-5,12-14,22H,6-11,15-17H2,(H,32,33)/t22-/s2
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n/an/a 117n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371995
PNG
(3-[2-(3,3-Difluoroazetidin-1-yl)-2-oxoethyl]-8-(1H...)
Show SMILES FC1(F)CN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C26H26F2N6O3/c27-26(28)15-33(16-26)22(35)14-32-17-34(20-4-2-1-3-5-20)25(24(32)37)8-10-31(11-9-25)23(36)18-6-7-21-19(12-18)13-29-30-21/h1-7,12-13H,8-11,14-17H2,(H,29,30)
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n/an/a 131n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372135
PNG
(N-(1-hydroxy-2-methylpropan-2-yl)-2-[8-(1H-indazol...)
Show SMILES CC(C)(CO)NC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C27H32N6O4/c1-26(2,17-34)29-23(35)16-32-18-33(21-6-4-3-5-7-21)27(25(32)37)10-12-31(13-11-27)24(36)19-8-9-22-20(14-19)15-28-30-22/h3-9,14-15,34H,10-13,16-18H2,1-2H3,(H,28,30)(H,29,35)
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n/an/a 144n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371947
PNG
(3-[[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]methyl...)
Show SMILES Fc1ccc(cc1)-c1noc(CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3ccc4[nH]ncc4c3)C2=O)n1
Show InChI InChI=1S/C30H26FN7O3/c31-23-9-6-20(7-10-23)27-33-26(41-35-27)18-37-19-38(24-4-2-1-3-5-24)30(29(37)40)12-14-36(15-13-30)28(39)21-8-11-25-22(16-21)17-32-34-25/h1-11,16-17H,12-15,18-19H2,(H,32,34)
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n/an/a 155n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372116
PNG
(N-[2-(Dimethylamino)ethyl]-2-[4-oxo-1-phenyl-8-(1H...)
Show SMILES CN(C)CCN(CC(F)(F)F)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C28H33F3N8O3/c1-35(2)12-13-37(18-28(29,30)31)23(40)17-38-19-39(22-6-4-3-5-7-22)27(26(38)42)8-10-36(11-9-27)25(41)21-14-20-16-33-34-24(20)32-15-21/h3-7,14-16H,8-13,17-19H2,1-2H3,(H,32,33,34)
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n/an/a 155n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371970
PNG
(3-[(2-tert-Butyl-5-methy-1,3-oxazol-4-yl)methyl]-8...)
Show SMILES Cc1oc(nc1CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)C(C)(C)C
Show InChI InChI=1S/C30H34N6O3/c1-20-25(32-27(39-20)29(2,3)4)18-35-19-36(23-8-6-5-7-9-23)30(28(35)38)12-14-34(15-13-30)26(37)21-10-11-24-22(16-21)17-31-33-24/h5-11,16-17H,12-15,18-19H2,1-4H3,(H,31,33)
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n/an/a 158n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371971
PNG
(3-[(3-tert-Butyl-1,2,4-thiadiazol-5-yl)methyl]-8-(...)
Show SMILES CC(C)(C)c1nsc(CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3ccc4[nH]ncc4c3)C2=O)n1
Show InChI InChI=1S/C28H31N7O2S/c1-27(2,3)25-30-23(38-32-25)17-34-18-35(21-7-5-4-6-8-21)28(26(34)37)11-13-33(14-12-28)24(36)19-9-10-22-20(15-19)16-29-31-22/h4-10,15-16H,11-14,17-18H2,1-3H3,(H,29,31)
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n/an/a 184n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372072
PNG
(3-(2-Oxo-2-pyrrolidin-1-ylethyl)-1-phenyl-8-(1H-py...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)N1CCCC1
Show InChI InChI=1S/C26H29N7O3/c34-22(30-10-4-5-11-30)17-32-18-33(21-6-2-1-3-7-21)26(25(32)36)8-12-31(13-9-26)24(35)20-14-19-16-28-29-23(19)27-15-20/h1-3,6-7,14-16H,4-5,8-13,17-18H2,(H,27,28,29)
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n/an/a 184n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372141
PNG
(8-(1H-indazole-5-carbonyl)-3-[2-oxo-2-[2-(trifluor...)
Show SMILES FC(F)(F)C1CNCCN1C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C28H30F3N7O3/c29-28(30,31)23-16-32-10-13-37(23)24(39)17-36-18-38(21-4-2-1-3-5-21)27(26(36)41)8-11-35(12-9-27)25(40)19-6-7-22-20(14-19)15-33-34-22/h1-7,14-15,23,32H,8-13,16-18H2,(H,33,34)
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n/an/a 197n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372118
PNG
(2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...)
Show SMILES FC(F)(F)Cn1ccc(NC(=O)CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3cnc4[nH]ncc4c3)C2=O)n1
Show InChI InChI=1S/C27H26F3N9O3/c28-27(29,30)16-38-9-6-21(35-38)33-22(40)15-37-17-39(20-4-2-1-3-5-20)26(25(37)42)7-10-36(11-8-26)24(41)19-12-18-14-32-34-23(18)31-13-19/h1-6,9,12-14H,7-8,10-11,15-17H2,(H,31,32,34)(H,33,35,40)
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n/an/a 208n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371824
PNG
(2-[1-(2-Fluoro-phenyl)-4-oxo-8-(1H-pyrazolo[3,4-b]...)
Show SMILES Fc1ccccc1N1CN(CC(=O)NCC(F)(F)F)C(=O)C11CCN(CC1)C(=O)c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C24H23F4N7O3/c25-17-3-1-2-4-18(17)35-14-34(12-19(36)30-13-24(26,27)28)22(38)23(35)5-7-33(8-6-23)21(37)16-9-15-11-31-32-20(15)29-10-16/h1-4,9-11H,5-8,12-14H2,(H,30,36)(H,29,31,32)
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n/an/a 210n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372089
PNG
(1-[2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)N1CCC(C1)C#N
Show InChI InChI=1/C27H28N8O3/c28-13-19-6-9-33(16-19)23(36)17-34-18-35(22-4-2-1-3-5-22)27(26(34)38)7-10-32(11-8-27)25(37)21-12-20-15-30-31-24(20)29-14-21/h1-5,12,14-15,19H,6-11,16-18H2,(H,29,30,31)
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n/an/a 219n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372003
PNG
(3-[2-[(3R)-3-(Dimethylamino)pyrrolidin-1-yl]-2-oxo...)
Show SMILES CN(C)[C@@H]1CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C29H35N7O3/c1-32(2)24-10-13-34(18-24)26(37)19-35-20-36(23-6-4-3-5-7-23)29(28(35)39)11-14-33(15-12-29)27(38)21-8-9-25-22(16-21)17-30-31-25/h3-9,16-17,24H,10-15,18-20H2,1-2H3,(H,30,31)/t24-/s2
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n/an/a 222n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372026
PNG
((RS)-3-[2-(3-Methoxypyrrolidin-1-yl)-2-oxoethyl]-1...)
Show SMILES COC1CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C27H31N7O4/c1-38-22-7-10-32(16-22)23(35)17-33-18-34(21-5-3-2-4-6-21)27(26(33)37)8-11-31(12-9-27)25(36)20-13-19-15-29-30-24(19)28-14-20/h2-6,13-15,22H,7-12,16-18H2,1H3,(H,28,29,30)
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n/an/a 225n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372093
PNG
((R)-3-(2-Oxo-2-(2-(trifluoromethyl)pyrrolidin-1-yl...)
Show SMILES FC(F)(F)[C@H]1CCCN1C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C27H28F3N7O3/c28-27(29,30)21-7-4-10-36(21)22(38)16-35-17-37(20-5-2-1-3-6-20)26(25(35)40)8-11-34(12-9-26)24(39)19-13-18-15-32-33-23(18)31-14-19/h1-3,5-6,13-15,21H,4,7-12,16-17H2,(H,31,32,33)/t21-/s2
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n/an/a 239n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371855
PNG
(2-[8-(1H-Indazole-6-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3cn[nH]c3c2)C1=O
Show InChI InChI=1S/C25H25F3N6O3/c26-25(27,28)15-29-21(35)14-33-16-34(19-4-2-1-3-5-19)24(23(33)37)8-10-32(11-9-24)22(36)17-6-7-18-13-30-31-20(18)12-17/h1-7,12-13H,8-11,14-16H2,(H,29,35)(H,30,31)
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n/an/a 258n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372095
PNG
(N-((rac, trans)-2-(3-((4-Methylpiperazin-1-yl)meth...)
Show SMILES CN1CCN(Cc2cccc(c2)[C@H]2C[C@@H]2NC(=O)CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3cnc4[nH]ncc4c3)C2=O)CC1
Show InChI InChI=1/C37H43N9O3/c1-42-14-16-43(17-15-42)23-26-6-5-7-27(18-26)31-20-32(31)40-33(47)24-45-25-46(30-8-3-2-4-9-30)37(36(45)49)10-12-44(13-11-37)35(48)29-19-28-22-39-41-34(28)38-21-29/h2-9,18-19,21-22,31-32H,10-17,20,23-25H2,1H3,(H,40,47)(H,38,39,41)/t31-,32+/s2
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n/an/a 260n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372074
PNG
(3-(2-Morpholino-2-oxoethyl)-1-phenyl-8-(1H-pyrazol...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)N1CCOCC1
Show InChI InChI=1S/C26H29N7O4/c34-22(30-10-12-37-13-11-30)17-32-18-33(21-4-2-1-3-5-21)26(25(32)36)6-8-31(9-7-26)24(35)20-14-19-16-28-29-23(19)27-15-20/h1-5,14-16H,6-13,17-18H2,(H,27,28,29)
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n/an/a 265n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372108
PNG
(3-[2-[(rac, trans)-3-Hydroxy-4-methylpyrrolidin-1-...)
Show SMILES C[C@H]1CN(C[C@@H]1O)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C27H31N7O4/c1-18-14-32(15-22(18)35)23(36)16-33-17-34(21-5-3-2-4-6-21)27(26(33)38)7-9-31(10-8-27)25(37)20-11-19-13-29-30-24(19)28-12-20/h2-6,11-13,18,22,35H,7-10,14-17H2,1H3,(H,28,29,30)/t18-,22-/s2
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n/an/a 272n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371986
PNG
(3-(1,5-Dimethylpyrazol-3-yl)-8-(1H-indazole-5-carb...)
Show SMILES Cc1cc(nn1C)N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C26H27N7O2/c1-18-14-23(29-30(18)2)32-17-33(21-6-4-3-5-7-21)26(25(32)35)10-12-31(13-11-26)24(34)19-8-9-22-20(15-19)16-27-28-22/h3-9,14-16H,10-13,17H2,1-2H3,(H,27,28)
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n/an/a 289n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371990
PNG
((RS)-8-(1H-Indazole-5-carbonyl)-3-[2-oxo-2-[3-(1,2...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)N1CCC(C1)n1cncn1
Show InChI InChI=1/C29H31N9O3/c39-26(35-11-8-24(16-35)38-19-30-18-32-38)17-36-20-37(23-4-2-1-3-5-23)29(28(36)41)9-12-34(13-10-29)27(40)21-6-7-25-22(14-21)15-31-33-25/h1-7,14-15,18-19,24H,8-13,16-17,20H2,(H,31,33)
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n/an/a 311n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371940
PNG
(8-(1H-Indazole-5-carbonyl)-3-[(3-methyl-1,2,4-oxad...)
Show SMILES Cc1noc(CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3ccc4[nH]ncc4c3)C2=O)n1
Show InChI InChI=1S/C25H25N7O3/c1-17-27-22(35-29-17)15-31-16-32(20-5-3-2-4-6-20)25(24(31)34)9-11-30(12-10-25)23(33)18-7-8-21-19(13-18)14-26-28-21/h2-8,13-14H,9-12,15-16H2,1H3,(H,26,28)
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n/an/a 312n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372070
PNG
(N-(2-fluoroethyl)-2-[4-oxo-1-phenyl-8-(1H-pyrazolo...)
Show SMILES FCCNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C24H26FN7O3/c25-8-9-26-20(33)15-31-16-32(19-4-2-1-3-5-19)24(23(31)35)6-10-30(11-7-24)22(34)18-12-17-14-28-29-21(17)27-13-18/h1-5,12-14H,6-11,15-16H2,(H,26,33)(H,27,28,29)
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n/an/a 322n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371896
PNG
(2-(8-(1H-Benzo[d][1,2,3]triazole-5-carbonyl)-4-oxo...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]nnc3c2)C1=O
Show InChI InChI=1S/C24H24F3N7O3/c25-24(26,27)14-28-20(35)13-33-15-34(17-4-2-1-3-5-17)23(22(33)37)8-10-32(11-9-23)21(36)16-6-7-18-19(12-16)30-31-29-18/h1-7,12H,8-11,13-15H2,(H,28,35)(H,29,30,31)
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n/an/a 345n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372047
PNG
((RS)-3-[2-(3-Hydroxy-3-methylpyrrolidin-1-yl)-2-ox...)
Show SMILES CC1(O)CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C27H31N7O4/c1-26(38)7-10-32(17-26)22(35)16-33-18-34(21-5-3-2-4-6-21)27(25(33)37)8-11-31(12-9-27)24(36)20-13-19-15-29-30-23(19)28-14-20/h2-6,13-15,38H,7-12,16-18H2,1H3,(H,28,29,30)
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n/an/a 359n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372018
PNG
(8-(1H-Indazole-5-carbonyl)-3-[2-[(2R)-2-(methoxyme...)
Show SMILES COC[C@H]1CCCN1C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C29H34N6O4/c1-39-19-24-8-5-13-34(24)26(36)18-33-20-35(23-6-3-2-4-7-23)29(28(33)38)11-14-32(15-12-29)27(37)21-9-10-25-22(16-21)17-30-31-25/h2-4,6-7,9-10,16-17,24H,5,8,11-15,18-20H2,1H3,(H,30,31)/t24-/s2
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Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372024
PNG
(3-[2-[(3S)-3-Fluoropyrrolidin-1-yl]-2-oxoethyl]-1-...)
Show SMILES F[C@H]1CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C26H28FN7O3/c27-20-6-9-32(15-20)22(35)16-33-17-34(21-4-2-1-3-5-21)26(25(33)37)7-10-31(11-8-26)24(36)19-12-18-14-29-30-23(18)28-13-19/h1-5,12-14,20H,6-11,15-17H2,(H,28,29,30)/t20-/s2
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n/an/a 394n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372103
PNG
(3-[2-(4-Cyclopropylpiperazin-1-yl)-2-oxoethyl]-1-p...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)N1CCN(CC1)C1CC1
Show InChI InChI=1S/C29H34N8O3/c38-25(34-14-12-33(13-15-34)23-6-7-23)19-36-20-37(24-4-2-1-3-5-24)29(28(36)40)8-10-35(11-9-29)27(39)22-16-21-18-31-32-26(21)30-17-22/h1-5,16-18,23H,6-15,19-20H2,(H,30,31,32)
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n/an/a 404n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372099
PNG
(N-((rac, trans)-2-(3-(Morpholinomethyl)phenyl)cycl...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)N[C@H]1C[C@@H]1c1cccc(CN2CCOCC2)c1
Show InChI InChI=1/C36H40N8O4/c45-32(39-31-19-30(31)26-6-4-5-25(17-26)22-41-13-15-48-16-14-41)23-43-24-44(29-7-2-1-3-8-29)36(35(43)47)9-11-42(12-10-36)34(46)28-18-27-21-38-40-33(27)37-20-28/h1-8,17-18,20-21,30-31H,9-16,19,22-24H2,(H,39,45)(H,37,38,40)/t30-,31+/s2
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n/an/a 426n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371820
PNG
((2-[1-(4-Fluoro-phenyl)-4-oxo-8-(1H-pyrazolo[3,4-b...)
Show SMILES Fc1ccc(cc1)N1CN(CC(=O)NCC(F)(F)F)C(=O)C11CCN(CC1)C(=O)c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C24H23F4N7O3/c25-17-1-3-18(4-2-17)35-14-34(12-19(36)30-13-24(26,27)28)22(38)23(35)5-7-33(8-6-23)21(37)16-9-15-11-31-32-20(15)29-10-16/h1-4,9-11H,5-8,12-14H2,(H,30,36)(H,29,31,32)
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n/an/a 436n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372086
PNG
(3-[(6-Methylpyridin-2-yl)methyl]-1-phenyl-8-(1H-py...)
Show SMILES Cc1cccc(CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3cnc4[nH]ncc4c3)C2=O)n1
Show InChI InChI=1S/C27H27N7O2/c1-19-6-5-7-22(30-19)17-33-18-34(23-8-3-2-4-9-23)27(26(33)36)10-12-32(13-11-27)25(35)21-14-20-16-29-31-24(20)28-15-21/h2-9,14-16H,10-13,17-18H2,1H3,(H,28,29,31)
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n/an/a 446n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372107
PNG
(3-[2-[(rac, cis)-3-Hydroxy-4-methylpyrrolidin-1-yl...)
Show SMILES C[C@H]1CN(C[C@H]1O)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C27H31N7O4/c1-18-14-32(15-22(18)35)23(36)16-33-17-34(21-5-3-2-4-6-21)27(26(33)38)7-9-31(10-8-27)25(37)20-11-19-13-29-30-24(19)28-12-20/h2-6,11-13,18,22,35H,7-10,14-17H2,1H3,(H,28,29,30)/t18-,22+/s2
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n/an/a 456n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371951
PNG
((3S,4R or 3R,4S)-2-[8-(1H-Indazole-5-carbonyl)-4-o...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)N[C@@H]1CNC[C@H]1c1ccccc1
Show InChI InChI=1/C33H35N7O3/c41-30(36-29-20-34-19-27(29)23-7-3-1-4-8-23)21-39-22-40(26-9-5-2-6-10-26)33(32(39)43)13-15-38(16-14-33)31(42)24-11-12-28-25(17-24)18-35-37-28/h1-12,17-18,27,29,34H,13-16,19-22H2,(H,35,37)(H,36,41)/t27-,29+/s2
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n/an/a 473n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372127
PNG
(US10239876, Example 150 | tert-Butyl (2S)- or (2R)...)
Show SMILES CC(C)(C)OC(=O)N1CCN(C[C@H]1C(F)(F)F)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C33H38F3N7O5/c1-31(2,3)48-30(47)42-16-15-40(19-26(42)33(34,35)36)27(44)20-41-21-43(24-7-5-4-6-8-24)32(29(41)46)11-13-39(14-12-32)28(45)22-9-10-25-23(17-22)18-37-38-25/h4-10,17-18,26H,11-16,19-21H2,1-3H3,(H,37,38)/t26-/s2
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n/an/a 474n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371829
PNG
(2-(8-(1H-Indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)Nc1ccccc1
Show InChI InChI=1S/C29H28N6O3/c36-26(31-23-7-3-1-4-8-23)19-34-20-35(24-9-5-2-6-10-24)29(28(34)38)13-15-33(16-14-29)27(37)21-11-12-25-22(17-21)18-30-32-25/h1-12,17-18H,13-16,19-20H2,(H,30,32)(H,31,36)
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n/an/a 496n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371825
PNG
(2-(1-(3,4-Dichlorophenyl)-8-(1H-indazole-5-carbony...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2ccc(Cl)c(Cl)c2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C25H23Cl2F3N6O3/c26-18-3-2-17(10-19(18)27)36-14-35(12-21(37)31-13-25(28,29)30)23(39)24(36)5-7-34(8-6-24)22(38)15-1-4-20-16(9-15)11-32-33-20/h1-4,9-11H,5-8,12-14H2,(H,31,37)(H,32,33)
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n/an/a 504n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372142
PNG
(3-[2-[4-Benzyl-2-(trifluoromethyl)piperazin-1-yl]-...)
Show SMILES FC(F)(F)C1CN(Cc2ccccc2)CCN1C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C35H36F3N7O3/c36-35(37,38)30-22-41(21-25-7-3-1-4-8-25)17-18-44(30)31(46)23-43-24-45(28-9-5-2-6-10-28)34(33(43)48)13-15-42(16-14-34)32(47)26-11-12-29-27(19-26)20-39-40-29/h1-12,19-20,30H,13-18,21-24H2,(H,39,40)
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n/an/a 518n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372073
PNG
(3-[2-[(3R)-3-(Dimethylamino)pyrrolidin-1-yl]-2-oxo...)
Show SMILES CN(C)[C@@H]1CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C28H34N8O3/c1-32(2)23-8-11-34(17-23)24(37)18-35-19-36(22-6-4-3-5-7-22)28(27(35)39)9-12-33(13-10-28)26(38)21-14-20-16-30-31-25(20)29-15-21/h3-7,14-16,23H,8-13,17-19H2,1-2H3,(H,29,30,31)/t23-/s2
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n/an/a 530n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372138
PNG
(N-(1-hydroxy-2-methylpropan-2-yl)-2-[4-oxo-1-pheny...)
Show SMILES CC(C)(CO)NC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C26H31N7O4/c1-25(2,16-34)29-21(35)15-32-17-33(20-6-4-3-5-7-20)26(24(32)37)8-10-31(11-9-26)23(36)19-12-18-14-28-30-22(18)27-13-19/h3-7,12-14,34H,8-11,15-17H2,1-2H3,(H,29,35)(H,27,28,30)
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n/an/a 550n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372104
PNG
(3-[2-Oxo-2-(3,3,4-trimethylpiperazin-1-yl)ethyl]-1...)
Show SMILES CN1CCN(CC1(C)C)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C29H36N8O3/c1-28(2)19-35(14-13-33(28)3)24(38)18-36-20-37(23-7-5-4-6-8-23)29(27(36)40)9-11-34(12-10-29)26(39)22-15-21-17-31-32-25(21)30-16-22/h4-8,15-17H,9-14,18-20H2,1-3H3,(H,30,31,32)
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n/an/a 564n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372055
PNG
((RS)-3-(1-Cyclopropyl-2-oxopyrrolidin-3-yl)-1-phen...)
Show SMILES O=C(N1CCC2(CC1)N(CN(C1CCN(C3CC3)C1=O)C2=O)c1ccccc1)c1cnc2[nH]ncc2c1
Show InChI InChI=1/C27H29N7O3/c35-24(19-14-18-16-29-30-23(18)28-15-19)31-12-9-27(10-13-31)26(37)33(17-34(27)21-4-2-1-3-5-21)22-8-11-32(25(22)36)20-6-7-20/h1-5,14-16,20,22H,6-13,17H2,(H,28,29,30)
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n/an/a 565n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371974
PNG
((3R,4S or 3S,4R)-2-[8-(1H-Indazole-5-carbonyl)-4-o...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)N[C@H]1CNC[C@@H]1c1ccccc1
Show InChI InChI=1/C33H35N7O3/c41-30(36-29-20-34-19-27(29)23-7-3-1-4-8-23)21-39-22-40(26-9-5-2-6-10-26)33(32(39)43)13-15-38(16-14-33)31(42)24-11-12-28-25(17-24)18-35-37-28/h1-12,17-18,27,29,34H,13-16,19-22H2,(H,35,37)(H,36,41)/t27-,29+/s2
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n/an/a 577n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372020
PNG
(N-(Oxetan-3-yl)-2-[4-oxo-1-phenyl-8-(1H-pyrazolo[3...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)NC1COC1
Show InChI InChI=1S/C25H27N7O4/c33-21(28-19-14-36-15-19)13-31-16-32(20-4-2-1-3-5-20)25(24(31)35)6-8-30(9-7-25)23(34)18-10-17-12-27-29-22(17)26-11-18/h1-5,10-12,19H,6-9,13-16H2,(H,28,33)(H,26,27,29)
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n/an/a 663n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372091
PNG
((+)-2-[8-(1H-indazole-5-carbonyl)-4-oxo-1-phenyl-1...)
Show SMILES C[C@H](N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)C(=O)NCC(F)(F)F
Show InChI InChI=1/C26H27F3N6O3/c1-17(22(36)30-15-26(27,28)29)34-16-35(20-5-3-2-4-6-20)25(24(34)38)9-11-33(12-10-25)23(37)18-7-8-21-19(13-18)14-31-32-21/h2-8,13-14,17H,9-12,15-16H2,1H3,(H,30,36)(H,31,32)/t17-/s2
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n/an/a 670n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372051
PNG
(3-[2-[(3S)-3-(Dimethylamino)pyrrolidin-1-yl]-2-oxo...)
Show SMILES CN(C)[C@H]1CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C28H34N8O3/c1-32(2)23-8-11-34(17-23)24(37)18-35-19-36(22-6-4-3-5-7-22)28(27(35)39)9-12-33(13-10-28)26(38)21-14-20-16-30-31-25(20)29-15-21/h3-7,14-16,23H,8-13,17-19H2,1-2H3,(H,29,30,31)/t23-/s2
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n/an/a 694n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371839
PNG
(2-(8-(1H-Indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)Nc1ccncc1
Show InChI InChI=1S/C28H27N7O3/c36-25(31-22-8-12-29-13-9-22)18-34-19-35(23-4-2-1-3-5-23)28(27(34)38)10-14-33(15-11-28)26(37)20-6-7-24-21(16-20)17-30-32-24/h1-9,12-13,16-17H,10-11,14-15,18-19H2,(H,30,32)(H,29,31,36)
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n/an/a 779n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372017
PNG
((rac, cis)-3-[2-(2-Benzyl-1,3,3a,4,6,6a-hexahydrop...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)N1C[C@@H]2CN(Cc3ccccc3)C[C@@H]2C1
Show InChI InChI=1/C36H39N7O3/c44-33(41-22-29-20-39(21-30(29)23-41)19-26-7-3-1-4-8-26)24-42-25-43(31-9-5-2-6-10-31)36(35(42)46)13-15-40(16-14-36)34(45)27-11-12-32-28(17-27)18-37-38-32/h1-12,17-18,29-30H,13-16,19-25H2,(H,37,38)/t29-,30+
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n/an/a 807n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372147
PNG
(2-[1-(3-Cyanophenyl)-4-oxo-8-(1H-pyrazolo[3,4-b]py...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2cccc(c2)C#N)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C25H23F3N8O3/c26-25(27,28)14-31-20(37)13-35-15-36(19-3-1-2-16(8-19)10-29)24(23(35)39)4-6-34(7-5-24)22(38)18-9-17-12-32-33-21(17)30-11-18/h1-3,8-9,11-12H,4-7,13-15H2,(H,31,37)(H,30,32,33)
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n/an/a 854n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371938
PNG
(8-(1H-Indazole-5-carbonyl)-3-[(1-methylimidazol-2-...)
Show SMILES Cn1ccnc1CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C26H27N7O2/c1-30-14-11-27-23(30)17-32-18-33(21-5-3-2-4-6-21)26(25(32)35)9-12-31(13-10-26)24(34)19-7-8-22-20(15-19)16-28-29-22/h2-8,11,14-16H,9-10,12-13,17-18H2,1H3,(H,28,29)
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n/an/a 897n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372126
PNG
(US10239876, Example 149 | tert-Butyl (2R)- or (2S)...)
Show SMILES CC(C)(C)OC(=O)N1CCN(C[C@@H]1C(F)(F)F)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C33H38F3N7O5/c1-31(2,3)48-30(47)42-16-15-40(19-26(42)33(34,35)36)27(44)20-41-21-43(24-7-5-4-6-8-24)32(29(41)46)11-13-39(14-12-32)28(45)22-9-10-25-23(17-22)18-37-38-25/h4-10,17-18,26H,11-16,19-21H2,1-3H3,(H,37,38)/t26-/s2
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n/an/a 906n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372077
PNG
(US10239876, Example 100 | tert-Butyl (3R)-3-[[2-[4...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H](C1)NC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C31H38N8O5/c1-30(2,3)44-29(43)37-12-9-23(18-37)34-25(40)19-38-20-39(24-7-5-4-6-8-24)31(28(38)42)10-13-36(14-11-31)27(41)22-15-21-17-33-35-26(21)32-16-22/h4-8,15-17,23H,9-14,18-20H2,1-3H3,(H,34,40)(H,32,33,35)/t23-/s2
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n/an/a 922n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371844
PNG
(2-(8-(1H-Indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Show SMILES FC(F)(F)Oc1cccc(NC(=O)CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3ccc4[nH]ncc4c3)C2=O)c1
Show InChI InChI=1S/C30H27F3N6O4/c31-30(32,33)43-24-8-4-5-22(16-24)35-26(40)18-38-19-39(23-6-2-1-3-7-23)29(28(38)42)11-13-37(14-12-29)27(41)20-9-10-25-21(15-20)17-34-36-25/h1-10,15-17H,11-14,18-19H2,(H,34,36)(H,35,40)
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n/an/a 923n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371842
PNG
(2-(8-(1H-Indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C33H35N7O4/c41-30(35-26-5-4-8-28(20-26)37-15-17-44-18-16-37)22-39-23-40(27-6-2-1-3-7-27)33(32(39)43)11-13-38(14-12-33)31(42)24-9-10-29-25(19-24)21-34-36-29/h1-10,19-21H,11-18,22-23H2,(H,34,36)(H,35,41)
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n/an/a 947n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372106
PNG
(3-[2-(4-Cyclopropyl-3-oxopiperazin-1-yl)-2-oxoethy...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)N1CCN(C2CC2)C(=O)C1
Show InChI InChI=1S/C29H32N8O4/c38-24(34-12-13-36(22-6-7-22)25(39)18-34)17-35-19-37(23-4-2-1-3-5-23)29(28(35)41)8-10-33(11-9-29)27(40)21-14-20-16-31-32-26(20)30-15-21/h1-5,14-16,22H,6-13,17-19H2,(H,30,31,32)
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n/an/a 1.03E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371827
PNG
(2-(1-(4-Chlorophenyl)-8-(1H-indazole-5-carbonyl)-4...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2ccc(Cl)cc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C25H24ClF3N6O3/c26-18-2-4-19(5-3-18)35-15-34(13-21(36)30-14-25(27,28)29)23(38)24(35)7-9-33(10-8-24)22(37)16-1-6-20-17(11-16)12-31-32-20/h1-6,11-12H,7-10,13-15H2,(H,30,36)(H,31,32)
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n/an/a 1.04E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372087
PNG
(6-[[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5...)
Show SMILES O=C(N1CCC2(CC1)N(CN(Cc1cccc(n1)C#N)C2=O)c1ccccc1)c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C27H24N8O2/c28-14-21-5-4-6-22(31-21)17-34-18-35(23-7-2-1-3-8-23)27(26(34)37)9-11-33(12-10-27)25(36)20-13-19-16-30-32-24(19)29-15-20/h1-8,13,15-16H,9-12,17-18H2,(H,29,30,32)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372057
PNG
(3-(2-Fluoro-5-trifluoromethyl-phenyl)-8-(1H-indazo...)
Show SMILES Fc1ccc(cc1N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)C(F)(F)F
Show InChI InChI=1S/C28H23F4N5O2/c29-22-8-7-20(28(30,31)32)15-24(22)36-17-37(21-4-2-1-3-5-21)27(26(36)39)10-12-35(13-11-27)25(38)18-6-9-23-19(14-18)16-33-34-23/h1-9,14-16H,10-13,17H2,(H,33,34)
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n/an/a 1.17E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371912
PNG
(3-(2-(4-Methylpiperazin-1-yl)-2-oxoethyl)-1-phenyl...)
Show SMILES CN1CCN(CC1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C27H32N8O3/c1-31-11-13-32(14-12-31)23(36)18-34-19-35(22-5-3-2-4-6-22)27(26(34)38)7-9-33(10-8-27)25(37)21-15-20-17-29-30-24(20)28-16-21/h2-6,15-17H,7-14,18-19H2,1H3,(H,28,29,30)
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n/an/a 1.19E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371988
PNG
(3-(2,4-Dimethyl-1,3-thiazol-5-yl)-8-(1H-indazole-5...)
Show SMILES Cc1nc(C)c(s1)N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C26H26N6O2S/c1-17-24(35-18(2)28-17)31-16-32(21-6-4-3-5-7-21)26(25(31)34)10-12-30(13-11-26)23(33)19-8-9-22-20(14-19)15-27-29-22/h3-9,14-15H,10-13,16H2,1-2H3,(H,27,29)
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n/an/a 1.35E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372049
PNG
(3-[2-[(3R)-3-Hydroxypyrrolidin-1-yl]-2-oxoethyl]-1...)
Show SMILES O[C@@H]1CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C26H29N7O4/c34-21-6-9-31(15-21)22(35)16-32-17-33(20-4-2-1-3-5-20)26(25(32)37)7-10-30(11-8-26)24(36)19-12-18-14-28-29-23(18)27-13-19/h1-5,12-14,21,34H,6-11,15-17H2,(H,27,28,29)/t21-/s2
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n/an/a 1.38E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372076
PNG
(US10239876, Example 99 | tert-Butyl (3S)-3-[[2-[4-...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@@H](C1)NC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C31H38N8O5/c1-30(2,3)44-29(43)37-12-9-23(18-37)34-25(40)19-38-20-39(24-7-5-4-6-8-24)31(28(38)42)10-13-36(14-11-31)27(41)22-15-21-17-33-35-26(21)32-16-22/h4-8,15-17,23H,9-14,18-20H2,1-3H3,(H,34,40)(H,32,33,35)/t23-/s2
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n/an/a 1.43E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371924
PNG
(2-[8-(1H-Indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Show SMILES CNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C24H26N6O3/c1-25-21(31)15-29-16-30(19-5-3-2-4-6-19)24(23(29)33)9-11-28(12-10-24)22(32)17-7-8-20-18(13-17)14-26-27-20/h2-8,13-14H,9-12,15-16H2,1H3,(H,25,31)(H,26,27)
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n/an/a 1.45E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371838
PNG
(2-(8-(1H-Indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)Nc1cccnc1
Show InChI InChI=1S/C28H27N7O3/c36-25(31-22-5-4-12-29-17-22)18-34-19-35(23-6-2-1-3-7-23)28(27(34)38)10-13-33(14-11-28)26(37)20-8-9-24-21(15-20)16-30-32-24/h1-9,12,15-17H,10-11,13-14,18-19H2,(H,30,32)(H,31,36)
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n/an/a 1.46E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372113
PNG
(3-[2-[3-[2-(Dimethylamino)ethyl]pyrrolidin-1-yl]-2...)
Show SMILES CN(C)CCC1CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C30H38N8O3/c1-34(2)12-8-22-9-13-36(19-22)26(39)20-37-21-38(25-6-4-3-5-7-25)30(29(37)41)10-14-35(15-11-30)28(40)24-16-23-18-32-33-27(23)31-17-24/h3-7,16-18,22H,8-15,19-21H2,1-2H3,(H,31,32,33)
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n/an/a 1.47E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372050
PNG
(3-[2-[(3S)-3-Hydroxypyrrolidin-1-yl]-2-oxoethyl]-1...)
Show SMILES O[C@H]1CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C26H29N7O4/c34-21-6-9-31(15-21)22(35)16-32-17-33(20-4-2-1-3-5-20)26(25(32)37)7-10-30(11-8-26)24(36)19-12-18-14-28-29-23(18)27-13-19/h1-5,12-14,21,34H,6-11,15-17H2,(H,27,28,29)/t21-/s2
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n/an/a 1.52E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372134
PNG
(1-[2-[8-(1H-indazole-5-carbonyl)-4-oxo-1-phenyl-1,...)
Show SMILES NC(=O)C1CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C28H31N7O4/c29-25(37)20-8-11-33(16-20)24(36)17-34-18-35(22-4-2-1-3-5-22)28(27(34)39)9-12-32(13-10-28)26(38)19-6-7-23-21(14-19)15-30-31-23/h1-7,14-15,20H,8-13,16-18H2,(H2,29,37)(H,30,31)
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n/an/a 1.56E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372105
PNG
(3-[2-Oxo-2-(3-pyrrolidin-1-ylpyrrolidin-1-yl)ethyl...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)N1CCC(C1)N1CCCC1
Show InChI InChI=1/C30H36N8O3/c39-26(36-13-8-25(19-36)34-11-4-5-12-34)20-37-21-38(24-6-2-1-3-7-24)30(29(37)41)9-14-35(15-10-30)28(40)23-16-22-18-32-33-27(22)31-17-23/h1-3,6-7,16-18,25H,4-5,8-15,19-21H2,(H,31,32,33)
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n/an/a 1.65E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372062
PNG
(3-(2-Fluoro-4-methyl-phenyl)-1-phenyl-8-(1H-pyrazo...)
Show SMILES Cc1ccc(N2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3cnc4[nH]ncc4c3)C2=O)c(F)c1
Show InChI InChI=1S/C27H25FN6O2/c1-18-7-8-23(22(28)13-18)33-17-34(21-5-3-2-4-6-21)27(26(33)36)9-11-32(12-10-27)25(35)20-14-19-16-30-31-24(19)29-15-20/h2-8,13-16H,9-12,17H2,1H3,(H,29,30,31)
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n/an/a 1.74E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372075
PNG
(2-[4-Oxo-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2cccnc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C23H23F3N8O3/c24-23(25,26)13-29-18(35)12-33-14-34(17-2-1-5-27-11-17)22(21(33)37)3-6-32(7-4-22)20(36)16-8-15-10-30-31-19(15)28-9-16/h1-2,5,8-11H,3-4,6-7,12-14H2,(H,29,35)(H,28,30,31)
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n/an/a 1.76E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372048
PNG
((3-[2-(2-Oxa-5-azaspiro[3.4]octan-5-yl)-2-oxoethyl...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)N1CCCC11COC1
Show InChI InChI=1S/C28H31N7O4/c36-23(34-10-4-7-27(34)17-39-18-27)16-33-19-35(22-5-2-1-3-6-22)28(26(33)38)8-11-32(12-9-28)25(37)21-13-20-15-30-31-24(20)29-14-21/h1-3,5-6,13-15H,4,7-12,16-19H2,(H,29,30,31)
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n/an/a 1.83E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372058
PNG
(3-(2-Chloro-5-trifluoromethyl-phenyl)-8-(1H-indazo...)
Show SMILES FC(F)(F)c1ccc(Cl)c(c1)N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C28H23ClF3N5O2/c29-22-8-7-20(28(30,31)32)15-24(22)36-17-37(21-4-2-1-3-5-21)27(26(36)39)10-12-35(13-11-27)25(38)18-6-9-23-19(14-18)16-33-34-23/h1-9,14-16H,10-13,17H2,(H,33,34)
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n/an/a 1.85E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371984
PNG
(3-(1-Ethylpyrazol-3-yl)-8-(1H-indazole-5-carbonyl)...)
Show SMILES CCn1ccc(n1)N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C26H27N7O2/c1-2-31-13-10-23(29-31)32-18-33(21-6-4-3-5-7-21)26(25(32)35)11-14-30(15-12-26)24(34)19-8-9-22-20(16-19)17-27-28-22/h3-10,13,16-17H,2,11-12,14-15,18H2,1H3,(H,27,28)
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n/an/a 2.11E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372096
PNG
(2-[8-(1H-indazole-5-carbonyl)-2,2-dimethyl-4-oxo-1...)
Show SMILES CC1(C)N(CC(=O)NCC(F)(F)F)C(=O)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)N1c1ccccc1
Show InChI InChI=1S/C27H29F3N6O3/c1-25(2)35(16-22(37)31-17-27(28,29)30)24(39)26(36(25)20-6-4-3-5-7-20)10-12-34(13-11-26)23(38)18-8-9-21-19(14-18)15-32-33-21/h3-9,14-15H,10-13,16-17H2,1-2H3,(H,31,37)(H,32,33)
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n/an/a 2.13E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372053
PNG
(N,N-Dimethyl-2-[4-oxo-1-phenyl-8-(1H-pyrazolo[3,4-...)
Show SMILES CN(C)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C24H27N7O3/c1-28(2)20(32)15-30-16-31(19-6-4-3-5-7-19)24(23(30)34)8-10-29(11-9-24)22(33)18-12-17-14-26-27-21(17)25-13-18/h3-7,12-14H,8-11,15-16H2,1-2H3,(H,25,26,27)
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n/an/a 2.28E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372066
PNG
(3-(5-Chloro-2-fluoro-4-methyl-phenyl)-1-phenyl-8-(...)
Show SMILES Cc1cc(F)c(cc1Cl)N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C27H24ClFN6O2/c1-17-11-22(29)23(13-21(17)28)34-16-35(20-5-3-2-4-6-20)27(26(34)37)7-9-33(10-8-27)25(36)19-12-18-15-31-32-24(18)30-14-19/h2-6,11-15H,7-10,16H2,1H3,(H,30,31,32)
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n/an/a 2.29E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372022
PNG
((rac, cis)-3-[2-(2-Benzyl-1,3,3a,4,6,6a-hexahydrop...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)N1C[C@@H]2CN(Cc3ccccc3)C[C@@H]2C1
Show InChI InChI=1/C35H38N8O3/c44-31(41-21-28-19-39(20-29(28)22-41)18-25-7-3-1-4-8-25)23-42-24-43(30-9-5-2-6-10-30)35(34(42)46)11-13-40(14-12-35)33(45)27-15-26-17-37-38-32(26)36-16-27/h1-10,15-17,28-29H,11-14,18-24H2,(H,36,37,38)/t28-,29+
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n/an/a 2.30E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371987
PNG
(3-(2,5-Dimethylpyrazol-3-yl)-8-(1H-indazole-5-carb...)
Show SMILES Cc1cc(N2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3ccc4[nH]ncc4c3)C2=O)n(C)n1
Show InChI InChI=1S/C26H27N7O2/c1-18-14-23(30(2)29-18)32-17-33(21-6-4-3-5-7-21)26(25(32)35)10-12-31(13-11-26)24(34)19-8-9-22-20(15-19)16-27-28-22/h3-9,14-16H,10-13,17H2,1-2H3,(H,27,28)
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n/an/a 2.31E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372061
PNG
(3-(2-Fluoro-4-trifluoromethyl-phenyl)-1-phenyl-8-(...)
Show SMILES Fc1cc(ccc1N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)C(F)(F)F
Show InChI InChI=1S/C27H22F4N6O2/c28-21-13-19(27(29,30)31)6-7-22(21)36-16-37(20-4-2-1-3-5-20)26(25(36)39)8-10-35(11-9-26)24(38)18-12-17-15-33-34-23(17)32-14-18/h1-7,12-15H,8-11,16H2,(H,32,33,34)
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n/an/a 2.35E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371918
PNG
(3-(2-(1,1-Dioxidothiomorpholino)-2-oxoethyl)-1-phe...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C26H29N7O5S/c34-22(30-10-12-39(37,38)13-11-30)17-32-18-33(21-4-2-1-3-5-21)26(25(32)36)6-8-31(9-7-26)24(35)20-14-19-16-28-29-23(19)27-15-20/h1-5,14-16H,6-13,17-18H2,(H,27,28,29)
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n/an/a 2.62E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371941
PNG
(8-(1H-Indazole-5-carbonyl)-3-[(5-methyl-1,3,4-oxad...)
Show SMILES Cc1nnc(CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3ccc4[nH]ncc4c3)C2=O)o1
Show InChI InChI=1S/C25H25N7O3/c1-17-27-29-22(35-17)15-31-16-32(20-5-3-2-4-6-20)25(24(31)34)9-11-30(12-10-25)23(33)18-7-8-21-19(13-18)14-26-28-21/h2-8,13-14H,9-12,15-16H2,1H3,(H,26,28)
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n/an/a 2.65E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372060
PNG
(1-Phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)...)
Show SMILES FC(F)(F)c1cccc(c1)N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C27H23F3N6O2/c28-27(29,30)20-5-4-8-22(14-20)35-17-36(21-6-2-1-3-7-21)26(25(35)38)9-11-34(12-10-26)24(37)19-13-18-16-32-33-23(18)31-15-19/h1-8,13-16H,9-12,17H2,(H,31,32,33)
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n/an/a 2.66E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372145
PNG
(2-[4-Oxo-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2cccc(c2)C(F)(F)F)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C25H23F6N7O3/c26-24(27,28)13-33-19(39)12-37-14-38(18-3-1-2-17(9-18)25(29,30)31)23(22(37)41)4-6-36(7-5-23)21(40)16-8-15-11-34-35-20(15)32-10-16/h1-3,8-11H,4-7,12-14H2,(H,33,39)(H,32,34,35)
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n/an/a 2.66E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372084
PNG
(3-[(−)-2-Oxo-1-(2,2,2-trifluoroethyl)pyrroli...)
Show SMILES FC(F)(F)CN1CC[C@H](N2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3cnc4[nH]ncc4c3)C2=O)C1=O
Show InChI InChI=1/C26H26F3N7O3/c27-26(28,29)15-34-9-6-20(23(34)38)35-16-36(19-4-2-1-3-5-19)25(24(35)39)7-10-33(11-8-25)22(37)18-12-17-14-31-32-21(17)30-13-18/h1-5,12-14,20H,6-11,15-16H2,(H,30,31,32)/t20-/s2
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n/an/a 2.72E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372021
PNG
((RS)-3-(1-Methyl-2-oxopiperidin-3-yl)-1-phenyl-8-(...)
Show SMILES CN1CCCC(N2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3cnc4[nH]ncc4c3)C2=O)C1=O
Show InChI InChI=1/C26H29N7O3/c1-30-11-5-8-21(24(30)35)32-17-33(20-6-3-2-4-7-20)26(25(32)36)9-12-31(13-10-26)23(34)19-14-18-16-28-29-22(18)27-15-19/h2-4,6-7,14-16,21H,5,8-13,17H2,1H3,(H,27,28,29)
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n/an/a 2.99E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371926
PNG
(3-(5-Chloro-2-fluorophenyl)-8-(1H-indazole-5-carbo...)
Show SMILES Fc1ccc(Cl)cc1N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C27H23ClFN5O2/c28-20-7-8-22(29)24(15-20)33-17-34(21-4-2-1-3-5-21)27(26(33)36)10-12-32(13-11-27)25(35)18-6-9-23-19(14-18)16-30-31-23/h1-9,14-16H,10-13,17H2,(H,30,31)
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n/an/a 3.11E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371962
PNG
((rac, trans)-2-[8-(1H-Indazole-5-carbonyl)-4-oxo-1...)
Show SMILES Cc1noc(n1)[C@@H]1CNC[C@H]1NC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C30H33N9O4/c1-19-33-27(43-36-19)23-15-31-16-25(23)34-26(40)17-38-18-39(22-5-3-2-4-6-22)30(29(38)42)9-11-37(12-10-30)28(41)20-7-8-24-21(13-20)14-32-35-24/h2-8,13-14,23,25,31H,9-12,15-18H2,1H3,(H,32,35)(H,34,40)/t23-,25-/s2
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n/an/a 3.32E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371985
PNG
(3-(1-Ethylpyrazol-4-yl)-8-(1H-indazole-5-carbonyl)...)
Show SMILES CCn1cc(cn1)N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C26H27N7O2/c1-2-31-17-22(16-28-31)32-18-33(21-6-4-3-5-7-21)26(25(32)35)10-12-30(13-11-26)24(34)19-8-9-23-20(14-19)15-27-29-23/h3-9,14-17H,2,10-13,18H2,1H3,(H,27,29)
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n/an/a 3.86E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372056
PNG
(8-(1H-Indazole-5-carbonyl)-1,3-diphenyl-1,3,8-tria...)
Show SMILES O=C(N1CCC2(CC1)N(CN(C2=O)c1ccccc1)c1ccccc1)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H25N5O2/c33-25(20-11-12-24-21(17-20)18-28-29-24)30-15-13-27(14-16-30)26(34)31(22-7-3-1-4-8-22)19-32(27)23-9-5-2-6-10-23/h1-12,17-18H,13-16,19H2,(H,28,29)
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n/an/a 4.79E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372112
PNG
(3-[2-[3-(Aminomethyl)pyrrolidin-1-yl]-2-oxoethyl]-...)
Show SMILES NCC1CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1/C27H32N8O3/c28-13-19-6-9-33(16-19)23(36)17-34-18-35(22-4-2-1-3-5-22)27(26(34)38)7-10-32(11-8-27)25(37)21-12-20-15-30-31-24(20)29-14-21/h1-5,12,14-15,19H,6-11,13,16-18,28H2,(H,29,30,31)
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n/an/a 4.85E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372069
PNG
(2-[8-(2-Aminopyrimidine-5-carbonyl)-4-oxo-1-phenyl...)
Show SMILES Nc1ncc(cn1)C(=O)N1CCC2(CC1)N(CN(CC(=O)NCC(F)(F)F)C2=O)c1ccccc1
Show InChI InChI=1S/C22H24F3N7O3/c23-22(24,25)13-29-17(33)12-31-14-32(16-4-2-1-3-5-16)21(19(31)35)6-8-30(9-7-21)18(34)15-10-27-20(26)28-11-15/h1-5,10-11H,6-9,12-14H2,(H,29,33)(H2,26,27,28)
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n/an/a 4.91E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372059
PNG
(3-(2-Fluoro-phenyl)-8-(1H-indazole-5-carbonyl)-1-p...)
Show SMILES Fc1ccccc1N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C27H24FN5O2/c28-22-8-4-5-9-24(22)32-18-33(21-6-2-1-3-7-21)27(26(32)35)12-14-31(15-13-27)25(34)19-10-11-23-20(16-19)17-29-30-23/h1-11,16-17H,12-15,18H2,(H,29,30)
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n/an/a 5.02E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372115
PNG
(N-[2-(Dimethylamino)ethyl]-2-[4-oxo-1-phenyl-8-(1H...)
Show SMILES CN(C)CCNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C26H32N8O3/c1-31(2)13-10-27-22(35)17-33-18-34(21-6-4-3-5-7-21)26(25(33)37)8-11-32(12-9-26)24(36)20-14-19-16-29-30-23(19)28-15-20/h3-7,14-16H,8-13,17-18H2,1-2H3,(H,27,35)(H,28,29,30)
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n/an/a 5.59E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372065
PNG
(3-(4-Chloro-2-fluoro-phenyl)-1-phenyl-8-(1H-pyrazo...)
Show SMILES Fc1cc(Cl)ccc1N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C26H22ClFN6O2/c27-19-6-7-22(21(28)13-19)33-16-34(20-4-2-1-3-5-20)26(25(33)36)8-10-32(11-9-26)24(35)18-12-17-15-30-31-23(17)29-14-18/h1-7,12-15H,8-11,16H2,(H,29,30,31)
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n/an/a 5.85E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372094
PNG
(US10239876, Example 117 | tert-Butyl 1-(2-(4-oxo-1...)
Show SMILES CC(C)(C)OC(=O)N1CC2(CCN2C(=O)CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3cnc4[nH]ncc4c3)C2=O)C1
Show InChI InChI=1S/C32H38N8O5/c1-30(2,3)45-29(44)38-19-31(20-38)9-14-39(31)25(41)18-37-21-40(24-7-5-4-6-8-24)32(28(37)43)10-12-36(13-11-32)27(42)23-15-22-17-34-35-26(22)33-16-23/h4-8,15-17H,9-14,18-21H2,1-3H3,(H,33,34,35)
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n/an/a 6.85E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372064
PNG
(3-(3-Chloro-phenyl)-1-phenyl-8-(1H-pyrazolo[3,4-b]...)
Show SMILES Clc1cccc(c1)N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C26H23ClN6O2/c27-20-5-4-8-22(14-20)32-17-33(21-6-2-1-3-7-21)26(25(32)35)9-11-31(12-10-26)24(34)19-13-18-16-29-30-23(18)28-15-19/h1-8,13-16H,9-12,17H2,(H,28,29,30)
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n/an/a 7.08E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371939
PNG
(8-(1H-Indazole-5-carbonyl)-3-[(2-methylpyrazol-3-y...)
Show SMILES Cn1nccc1CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O
Show InChI InChI=1S/C26H27N7O2/c1-30-22(9-12-28-30)17-32-18-33(21-5-3-2-4-6-21)26(25(32)35)10-13-31(14-11-26)24(34)19-7-8-23-20(15-19)16-27-29-23/h2-9,12,15-16H,10-11,13-14,17-18H2,1H3,(H,27,29)
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n/an/a 7.93E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371854
PNG
(2-(4-Oxo-1-phenyl-8-(tetrazolo[1,5-a]pyridine-6-ca...)
Show SMILES FC(F)(F)CNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3nnnn3c2)C1=O
Show InChI InChI=1S/C23H23F3N8O3/c24-23(25,26)14-27-19(35)13-32-15-33(17-4-2-1-3-5-17)22(21(32)37)8-10-31(11-9-22)20(36)16-6-7-18-28-29-30-34(18)12-16/h1-7,12H,8-11,13-15H2,(H,27,35)
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n/an/a 7.99E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM372063
PNG
(4-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...)
Show SMILES O=C(N1CCC2(CC1)N(CN(C2=O)c1ccc(cc1)C#N)c1ccccc1)c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C27H23N7O2/c28-15-19-6-8-22(9-7-19)33-18-34(23-4-2-1-3-5-23)27(26(33)36)10-12-32(13-11-27)25(35)21-14-20-17-30-31-24(20)29-16-21/h1-9,14,16-17H,10-13,18H2,(H,29,30,31)
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n/an/a 8.21E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM371895
PNG
(8-(1H-benzotriazole-5-carbonyl)-3-(2-morpholino-2-...)
Show SMILES O=C(CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]nnc3c2)C1=O)N1CCOCC1
Show InChI InChI=1S/C26H29N7O4/c34-23(30-12-14-37-15-13-30)17-32-18-33(20-4-2-1-3-5-20)26(25(32)36)8-10-31(11-9-26)24(35)19-6-7-21-22(16-19)28-29-27-21/h1-7,16H,8-15,17-18H2,(H,27,28,29)
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n/an/a 8.86E+3n/an/an/an/an/an/a



Hoffman La-Roche Inc.

US Patent


Assay Description
This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...


US Patent US10239876 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%