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Patent code US10239882

Compile Data Set for Download or QSAR
Found 86 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372184
PNG
(US10239882, Example 31)
Show SMILES COc1cccc(c1)-n1cc(CNc2nc3nc(C)cc(C4CCOCC4)n3n2)cn1
Show InChI InChI=1S/C22H25N7O2/c1-15-10-20(17-6-8-31-9-7-17)29-22(25-15)26-21(27-29)23-12-16-13-24-28(14-16)18-4-3-5-19(11-18)30-2/h3-5,10-11,13-14,17H,6-9,12H2,1-2H3,(H,23,27)
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n/an/a<100n/an/an/an/an/an/a



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372188
PNG
(US10239882, Example 39)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cccc(Br)c3)nc2n1
Show InChI InChI=1S/C18H20BrN5O/c1-12-9-16(14-5-7-25-8-6-14)24-18(21-12)22-17(23-24)20-11-13-3-2-4-15(19)10-13/h2-4,9-10,14H,5-8,11H2,1H3,(H,20,23)
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n/an/a<100n/an/an/an/an/an/a



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372191
PNG
(US10239882, Example 42)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3ccc4OCCc4c3)nc2n1
Show InChI InChI=1S/C20H23N5O2/c1-13-10-17(15-4-7-26-8-5-15)25-20(22-13)23-19(24-25)21-12-14-2-3-18-16(11-14)6-9-27-18/h2-3,10-11,15H,4-9,12H2,1H3,(H,21,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372208
PNG
(US10239882, Example 79)
Show SMILES Cc1nc(oc1CNc1nc2nc(C)cc(C3CCOCC3)n2n1)-c1ccccc1
Show InChI InChI=1S/C22H24N6O2/c1-14-12-18(16-8-10-29-11-9-16)28-22(24-14)26-21(27-28)23-13-19-15(2)25-20(30-19)17-6-4-3-5-7-17/h3-7,12,16H,8-11,13H2,1-2H3,(H,23,27)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372177
PNG
(US10239882, Example 19)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(C4CCN(CC4)C(C)=O)n3n2)cc1C(F)F
Show InChI InChI=1S/C22H26F2N6O2/c1-13-10-18(16-6-8-29(9-7-16)14(2)31)30-22(26-13)27-21(28-30)25-12-15-4-5-19(32-3)17(11-15)20(23)24/h4-5,10-11,16,20H,6-9,12H2,1-3H3,(H,25,28)
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n/an/a<100n/an/an/an/an/an/a



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372178
PNG
(US10239882, Example 20)
Show SMILES CC(=O)N1CCC(CC1)c1cc(C)nc2nc(NCc3cccc(c3)C(F)F)nn12
Show InChI InChI=1S/C21H24F2N6O/c1-13-10-18(16-6-8-28(9-7-16)14(2)30)29-21(25-13)26-20(27-29)24-12-15-4-3-5-17(11-15)19(22)23/h3-5,10-11,16,19H,6-9,12H2,1-2H3,(H,24,27)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372183
PNG
(US10239882, Example 30)
Show SMILES COc1ccc(CNc2nc3nc(CF)cc(C4CCOCC4)n3n2)cc1
Show InChI InChI=1S/C19H22FN5O2/c1-26-16-4-2-13(3-5-16)12-21-18-23-19-22-15(11-20)10-17(25(19)24-18)14-6-8-27-9-7-14/h2-5,10,14H,6-9,11-12H2,1H3,(H,21,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372192
PNG
(US10239882, Example 46)
Show SMILES Cc1nn(cc1CNc1nc2nc(C)cc(C3CCOCC3)n2n1)-c1ccccc1
Show InChI InChI=1S/C22H25N7O/c1-15-12-20(17-8-10-30-11-9-17)29-22(24-15)25-21(27-29)23-13-18-14-28(26-16(18)2)19-6-4-3-5-7-19/h3-7,12,14,17H,8-11,13H2,1-2H3,(H,23,27)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372193
PNG
(US10239882, Example 50)
Show SMILES COc1cc(F)c(CNc2nc3nc(C)cc(C4CCOCC4)n3n2)c(F)c1
Show InChI InChI=1S/C19H21F2N5O2/c1-11-7-17(12-3-5-28-6-4-12)26-19(23-11)24-18(25-26)22-10-14-15(20)8-13(27-2)9-16(14)21/h7-9,12H,3-6,10H2,1-2H3,(H,22,25)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372194
PNG
(US10239882, Example 52)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3ccnc(c3)C(F)F)nc2n1
Show InChI InChI=1S/C18H20F2N6O/c1-11-8-15(13-3-6-27-7-4-13)26-18(23-11)24-17(25-26)22-10-12-2-5-21-14(9-12)16(19)20/h2,5,8-9,13,16H,3-4,6-7,10H2,1H3,(H,22,25)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372195
PNG
(US10239882, Example 53)
Show SMILES Cc1cc(CNc2nc3nc(C)cc(C4CCOCC4)n3n2)cc(C)n1
Show InChI InChI=1S/C19H24N6O/c1-12-8-15(9-13(2)21-12)11-20-18-23-19-22-14(3)10-17(25(19)24-18)16-4-6-26-7-5-16/h8-10,16H,4-7,11H2,1-3H3,(H,20,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372203
PNG
(US10239882, Example 67)
Show SMILES Cc1nn(cc1CNc1nc2nc(C)cc(C3CCOCC3)n2n1)C1CCCC1
Show InChI InChI=1S/C21H29N7O/c1-14-11-19(16-7-9-29-10-8-16)28-21(23-14)24-20(26-28)22-12-17-13-27(25-15(17)2)18-5-3-4-6-18/h11,13,16,18H,3-10,12H2,1-2H3,(H,22,26)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372205
PNG
(US10239882, Example 74)
Show SMILES CC(C)c1cc(C)nc2nc(NCc3cn(nc3C)-c3ccccc3)nn12
Show InChI InChI=1S/C20H23N7/c1-13(2)18-10-14(3)22-20-23-19(25-27(18)20)21-11-16-12-26(24-15(16)4)17-8-6-5-7-9-17/h5-10,12-13H,11H2,1-4H3,(H,21,25)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372174
PNG
(US10239882, Example 13)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cc(Cl)ccc3F)nc2n1
Show InChI InChI=1S/C18H19ClFN5O/c1-11-8-16(12-4-6-26-7-5-12)25-18(22-11)23-17(24-25)21-10-13-9-14(19)2-3-15(13)20/h2-3,8-9,12H,4-7,10H2,1H3,(H,21,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372175
PNG
(US10239882, Example 15)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(C4CCOCC4)n3n2)c(F)c1
Show InChI InChI=1S/C19H22FN5O2/c1-12-9-17(13-5-7-27-8-6-13)25-19(22-12)23-18(24-25)21-11-14-3-4-15(26-2)10-16(14)20/h3-4,9-10,13H,5-8,11H2,1-2H3,(H,21,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372181
PNG
(US10239882, Example 25)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(C4CCOCC4)n3n2)cc1C(F)F
Show InChI InChI=1S/C20H23F2N5O2/c1-12-9-16(14-5-7-29-8-6-14)27-20(24-12)25-19(26-27)23-11-13-3-4-17(28-2)15(10-13)18(21)22/h3-4,9-10,14,18H,5-8,11H2,1-2H3,(H,23,26)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372200
PNG
(US10239882, Example 61)
Show SMILES Cc1nn(cc1CNc1nc2nc(C)cc(n2n1)C1(C)CCOCC1)-c1ccccc1
Show InChI InChI=1S/C23H27N7O/c1-16-13-20(23(3)9-11-31-12-10-23)30-22(25-16)26-21(28-30)24-14-18-15-29(27-17(18)2)19-7-5-4-6-8-19/h4-8,13,15H,9-12,14H2,1-3H3,(H,24,28)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372179
PNG
(US10239882, Example 21)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(C4CCOCC4)n3n2)cc1Cl
Show InChI InChI=1S/C19H22ClN5O2/c1-12-9-16(14-5-7-27-8-6-14)25-19(22-12)23-18(24-25)21-11-13-3-4-17(26-2)15(20)10-13/h3-4,9-10,14H,5-8,11H2,1-2H3,(H,21,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372185
PNG
(US10239882, Example 36)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cnn(c3)-c3ccccc3C)nc2n1
Show InChI InChI=1S/C22H25N7O/c1-15-5-3-4-6-19(15)28-14-17(13-24-28)12-23-21-26-22-25-16(2)11-20(29(22)27-21)18-7-9-30-10-8-18/h3-6,11,13-14,18H,7-10,12H2,1-2H3,(H,23,27)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372199
PNG
(US10239882, Example 60)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3ccnc4ccccc34)nc2n1
Show InChI InChI=1S/C21H22N6O/c1-14-12-19(15-7-10-28-11-8-15)27-21(24-14)25-20(26-27)23-13-16-6-9-22-18-5-3-2-4-17(16)18/h2-6,9,12,15H,7-8,10-11,13H2,1H3,(H,23,26)
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n/an/a<100n/an/an/an/an/an/a



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372202
PNG
(US10239882, Example 66)
Show SMILES CC(C)n1cc(CNc2nc3nc(C)cc(C4CCOCC4)n3n2)c(C)n1
Show InChI InChI=1S/C19H27N7O/c1-12(2)25-11-16(14(4)23-25)10-20-18-22-19-21-13(3)9-17(26(19)24-18)15-5-7-27-8-6-15/h9,11-12,15H,5-8,10H2,1-4H3,(H,20,24)
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n/an/a<100n/an/an/an/an/an/a



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372206
PNG
(US10239882, Example 76)
Show SMILES Cc1nn(cc1CNc1nc2nc(C)cc(n2n1)C1(C)CC1)-c1ccccc1
Show InChI InChI=1S/C21H23N7/c1-14-11-18(21(3)9-10-21)28-20(23-14)24-19(26-28)22-12-16-13-27(25-15(16)2)17-7-5-4-6-8-17/h4-8,11,13H,9-10,12H2,1-3H3,(H,22,26)
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Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372210
PNG
(US10239882, Example 81)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cc(F)cc(Br)c3)nc2n1
Show InChI InChI=1S/C18H19BrFN5O/c1-11-6-16(13-2-4-26-5-3-13)25-18(22-11)23-17(24-25)21-10-12-7-14(19)9-15(20)8-12/h6-9,13H,2-5,10H2,1H3,(H,21,24)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372176
PNG
(US10239882, Example 17)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cnn(c3)-c3ccccc3)nc2n1
Show InChI InChI=1S/C21H23N7O/c1-15-11-19(17-7-9-29-10-8-17)28-21(24-15)25-20(26-28)22-12-16-13-23-27(14-16)18-5-3-2-4-6-18/h2-6,11,13-14,17H,7-10,12H2,1H3,(H,22,26)
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Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372207
PNG
(US10239882, Example 78)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3ccc(F)c(Cl)c3F)nc2n1
Show InChI InChI=1S/C18H18ClF2N5O/c1-10-8-14(11-4-6-27-7-5-11)26-18(23-10)24-17(25-26)22-9-12-2-3-13(20)15(19)16(12)21/h2-3,8,11H,4-7,9H2,1H3,(H,22,25)
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Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372186
PNG
(US10239882, Example 37)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cc(no3)-c3ccccc3)nc2n1
Show InChI InChI=1S/C21H22N6O2/c1-14-11-19(16-7-9-28-10-8-16)27-21(23-14)24-20(25-27)22-13-17-12-18(26-29-17)15-5-3-2-4-6-15/h2-6,11-12,16H,7-10,13H2,1H3,(H,22,25)
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Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372187
PNG
(US10239882, Example 38)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(C4CCCOC4)n3n2)cc1
Show InChI InChI=1/C19H23N5O2/c1-13-10-17(15-4-3-9-26-12-15)24-19(21-13)22-18(23-24)20-11-14-5-7-16(25-2)8-6-14/h5-8,10,15H,3-4,9,11-12H2,1-2H3,(H,20,23)
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Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372189
PNG
(US10239882, Example 40)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cccc(Cl)c3)nc2n1
Show InChI InChI=1S/C18H20ClN5O/c1-12-9-16(14-5-7-25-8-6-14)24-18(21-12)22-17(23-24)20-11-13-3-2-4-15(19)10-13/h2-4,9-10,14H,5-8,11H2,1H3,(H,20,23)
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Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372190
PNG
(US10239882, Example 41)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cccc(c3)C(F)(F)F)nc2n1
Show InChI InChI=1S/C19H20F3N5O/c1-12-9-16(14-5-7-28-8-6-14)27-18(24-12)25-17(26-27)23-11-13-3-2-4-15(10-13)19(20,21)22/h2-4,9-10,14H,5-8,11H2,1H3,(H,23,26)
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Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372196
PNG
(US10239882, Example 54)
Show SMILES Cc1cncc(CNc2nc3nc(C)cc(C4CCOCC4)n3n2)c1
Show InChI InChI=1S/C18H22N6O/c1-12-7-14(10-19-9-12)11-20-17-22-18-21-13(2)8-16(24(18)23-17)15-3-5-25-6-4-15/h7-10,15H,3-6,11H2,1-2H3,(H,20,23)
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Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372201
PNG
(US10239882, Example 62)
Show SMILES Cc1cc(n2nc(NCc3cnn(c3)-c3ccccc3)nc2n1)C1(C)CCOCC1
Show InChI InChI=1S/C22H25N7O/c1-16-12-19(22(2)8-10-30-11-9-22)29-21(25-16)26-20(27-29)23-13-17-14-24-28(15-17)18-6-4-3-5-7-18/h3-7,12,14-15H,8-11,13H2,1-2H3,(H,23,27)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372180
PNG
(US10239882, Example 23)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cccc(c3)C(F)F)nc2n1
Show InChI InChI=1S/C19H21F2N5O/c1-12-9-16(14-5-7-27-8-6-14)26-19(23-12)24-18(25-26)22-11-13-3-2-4-15(10-13)17(20)21/h2-4,9-10,14,17H,5-8,11H2,1H3,(H,22,25)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372182
PNG
(US10239882, Example 29)
Show SMILES COc1ccc(CNc2nc3nc(cc(C4CCOCC4)n3n2)C(F)F)cc1
Show InChI InChI=1S/C19H21F2N5O2/c1-27-14-4-2-12(3-5-14)11-22-18-24-19-23-15(17(20)21)10-16(26(19)25-18)13-6-8-28-9-7-13/h2-5,10,13,17H,6-9,11H2,1H3,(H,22,25)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372197
PNG
(US10239882, Example 55)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(n3n2)C2(F)CCOCC2)cc1
Show InChI InChI=1S/C19H22FN5O2/c1-13-11-16(19(20)7-9-27-10-8-19)25-18(22-13)23-17(24-25)21-12-14-3-5-15(26-2)6-4-14/h3-6,11H,7-10,12H2,1-2H3,(H,21,24)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372198
PNG
(US10239882, Example 59)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3ccnc(c3)C(F)(F)F)nc2n1
Show InChI InChI=1S/C18H19F3N6O/c1-11-8-14(13-3-6-28-7-4-13)27-17(24-11)25-16(26-27)23-10-12-2-5-22-15(9-12)18(19,20)21/h2,5,8-9,13H,3-4,6-7,10H2,1H3,(H,23,26)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372204
PNG
(US10239882, Example 72)
Show SMILES Cc1nn(cc1CNc1nc2nc(C)cc(C3CCOC3)n2n1)-c1ccccc1
Show InChI InChI=1/C21H23N7O/c1-14-10-19(16-8-9-29-13-16)28-21(23-14)24-20(26-28)22-11-17-12-27(25-15(17)2)18-6-4-3-5-7-18/h3-7,10,12,16H,8-9,11,13H2,1-2H3,(H,22,26)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372209
PNG
(US10239882, Example 80)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cc(Cl)c(F)cc3F)nc2n1
Show InChI InChI=1S/C18H18ClF2N5O/c1-10-6-16(11-2-4-27-5-3-11)26-18(23-10)24-17(25-26)22-9-12-7-13(19)15(21)8-14(12)20/h6-8,11H,2-5,9H2,1H3,(H,22,25)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372211
PNG
(US10239882, Example 82)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cc(nn3C)-c3ccccc3)nc2n1
Show InChI InChI=1S/C22H25N7O/c1-15-12-20(17-8-10-30-11-9-17)29-22(24-15)25-21(27-29)23-14-18-13-19(26-28(18)2)16-6-4-3-5-7-16/h3-7,12-13,17H,8-11,14H2,1-2H3,(H,23,27)
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Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372213
PNG
(US10239882, Example 84)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cc(F)cc(Cl)c3)nc2n1
Show InChI InChI=1S/C18H19ClFN5O/c1-11-6-16(13-2-4-26-5-3-13)25-18(22-11)23-17(24-25)21-10-12-7-14(19)9-15(20)8-12/h6-9,13H,2-5,10H2,1H3,(H,21,24)
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Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372214
PNG
(US10239882, Example 85)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cc(nn3C)C(F)(F)F)nc2n1
Show InChI InChI=1S/C17H20F3N7O/c1-10-7-13(11-3-5-28-6-4-11)27-16(22-10)23-15(25-27)21-9-12-8-14(17(18,19)20)24-26(12)2/h7-8,11H,3-6,9H2,1-2H3,(H,21,25)
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Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372212
PNG
(US10239882, Example 83)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cccc(Br)c3F)nc2n1
Show InChI InChI=1S/C18H19BrFN5O/c1-11-9-15(12-5-7-26-8-6-12)25-18(22-11)23-17(24-25)21-10-13-3-2-4-14(19)16(13)20/h2-4,9,12H,5-8,10H2,1H3,(H,21,24)
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Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372215
PNG
(US10239882, Example 1)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(C4CCOCC4)n3n2)cc1
Show InChI InChI=1S/C19H23N5O2/c1-13-11-17(15-7-9-26-10-8-15)24-19(21-13)22-18(23-24)20-12-14-3-5-16(25-2)6-4-14/h3-6,11,15H,7-10,12H2,1-2H3,(H,20,23)
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Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372238
PNG
(US10239882, Example 51)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3c(F)cccc3F)nc2n1
Show InChI InChI=1S/C18H19F2N5O/c1-11-9-16(12-5-7-26-8-6-12)25-18(22-11)23-17(24-25)21-10-13-14(19)3-2-4-15(13)20/h2-4,9,12H,5-8,10H2,1H3,(H,21,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372226
PNG
(US10239882, Example 27)
Show SMILES Cc1ccc(F)c(CNc2nc3nc(C)cc(C4CCOCC4)n3n2)c1
Show InChI InChI=1S/C19H22FN5O/c1-12-3-4-16(20)15(9-12)11-21-18-23-19-22-13(2)10-17(25(19)24-18)14-5-7-26-8-6-14/h3-4,9-10,14H,5-8,11H2,1-2H3,(H,21,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372229
PNG
(US10239882, Example 33)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3ccccc3)nc2n1
Show InChI InChI=1S/C18H21N5O/c1-13-11-16(15-7-9-24-10-8-15)23-18(20-13)21-17(22-23)19-12-14-5-3-2-4-6-14/h2-6,11,15H,7-10,12H2,1H3,(H,19,22)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372244
PNG
(US10239882, Example 65)
Show SMILES Cc1nn(CC(F)F)cc1CNc1nc2nc(C)cc(C3CCOCC3)n2n1
Show InChI InChI=1S/C18H23F2N7O/c1-11-7-15(13-3-5-28-6-4-13)27-18(22-11)23-17(25-27)21-8-14-9-26(10-16(19)20)24-12(14)2/h7,9,13,16H,3-6,8,10H2,1-2H3,(H,21,25)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372220
PNG
(US10239882, Example 14)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cc(F)cc(F)c3)nc2n1
Show InChI InChI=1S/C18H19F2N5O/c1-11-6-16(13-2-4-26-5-3-13)25-18(22-11)23-17(24-25)21-10-12-7-14(19)9-15(20)8-12/h6-9,13H,2-5,10H2,1H3,(H,21,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372231
PNG
(US10239882, Example 35)
Show SMILES Cc1cc(CNc2nc3nc(C)cc(C4CCOCC4)n3n2)ccn1
Show InChI InChI=1S/C18H22N6O/c1-12-9-14(3-6-19-12)11-20-17-22-18-21-13(2)10-16(24(18)23-17)15-4-7-25-8-5-15/h3,6,9-10,15H,4-5,7-8,11H2,1-2H3,(H,20,23)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372232
PNG
(US10239882, Example 43)
Show SMILES Cc1cc(CNc2nc3nc(C)cc(n3n2)C2(C)CCOCC2)ccn1
Show InChI InChI=1S/C19H24N6O/c1-13-10-15(4-7-20-13)12-21-17-23-18-22-14(2)11-16(25(18)24-17)19(3)5-8-26-9-6-19/h4,7,10-11H,5-6,8-9,12H2,1-3H3,(H,21,24)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372233
PNG
(US10239882, Example 44)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(C4CCOC4)n3n2)cc1
Show InChI InChI=1/C18H21N5O2/c1-12-9-16(14-7-8-25-11-14)23-18(20-12)21-17(22-23)19-10-13-3-5-15(24-2)6-4-13/h3-6,9,14H,7-8,10-11H2,1-2H3,(H,19,22)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372248
PNG
(US10239882, Example 73)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cc(ccc3F)C#N)nc2n1
Show InChI InChI=1S/C19H19FN6O/c1-12-8-17(14-4-6-27-7-5-14)26-19(23-12)24-18(25-26)22-11-15-9-13(10-21)2-3-16(15)20/h2-3,8-9,14H,4-7,11H2,1H3,(H,22,25)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372227
PNG
(US10239882, Example 28)
Show SMILES Cc1cccc(CNc2nc3nc(C)cc(C4CCOCC4)n3n2)c1
Show InChI InChI=1S/C19H23N5O/c1-13-4-3-5-15(10-13)12-20-18-22-19-21-14(2)11-17(24(19)23-18)16-6-8-25-9-7-16/h3-5,10-11,16H,6-9,12H2,1-2H3,(H,20,23)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372228
PNG
(US10239882, Example 32)
Show SMILES COc1ccc(F)c(CNc2nc3nc(C)cc(C4CCOCC4)n3n2)c1
Show InChI InChI=1S/C19H22FN5O2/c1-12-9-17(13-5-7-27-8-6-13)25-19(22-12)23-18(24-25)21-11-14-10-15(26-2)3-4-16(14)20/h3-4,9-10,13H,5-8,11H2,1-2H3,(H,21,24)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372249
PNG
(US10239882, Example 75)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(n3n2)C2(C)CC2)cc1
Show InChI InChI=1S/C18H21N5O/c1-12-10-15(18(2)8-9-18)23-17(20-12)21-16(22-23)19-11-13-4-6-14(24-3)7-5-13/h4-7,10H,8-9,11H2,1-3H3,(H,19,22)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372218
PNG
(US10239882, Example 9)
Show SMILES Cc1cc(n2nc(NCc3cccc(Cl)c3)nc2n1)C(C)(C)C
Show InChI InChI=1S/C17H20ClN5/c1-11-8-14(17(2,3)4)23-16(20-11)21-15(22-23)19-10-12-6-5-7-13(18)9-12/h5-9H,10H2,1-4H3,(H,19,22)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372237
PNG
(US10239882, Example 49)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cc(F)ccc3F)nc2n1
Show InChI InChI=1S/C18H19F2N5O/c1-11-8-16(12-4-6-26-7-5-12)25-18(22-11)23-17(24-25)21-10-13-9-14(19)2-3-15(13)20/h2-3,8-9,12H,4-7,10H2,1H3,(H,21,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372224
PNG
(US10239882, Example 24)
Show SMILES COc1cccc(CNc2nc3nc(C)cc(C4CCOCC4)n3n2)c1
Show InChI InChI=1S/C19H23N5O2/c1-13-10-17(15-6-8-26-9-7-15)24-19(21-13)22-18(23-24)20-12-14-4-3-5-16(11-14)25-2/h3-5,10-11,15H,6-9,12H2,1-2H3,(H,20,23)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372223
PNG
(US10239882, Example 22)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(C4CCC(F)(F)CC4)n3n2)cc1
Show InChI InChI=1S/C20H23F2N5O/c1-13-11-17(15-7-9-20(21,22)10-8-15)27-19(24-13)25-18(26-27)23-12-14-3-5-16(28-2)6-4-14/h3-6,11,15H,7-10,12H2,1-2H3,(H,23,26)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372236
PNG
(US10239882, Example 48)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3ccccc3Cl)nc2n1
Show InChI InChI=1S/C18H20ClN5O/c1-12-10-16(13-6-8-25-9-7-13)24-18(21-12)22-17(23-24)20-11-14-4-2-3-5-15(14)19/h2-5,10,13H,6-9,11H2,1H3,(H,20,23)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372225
PNG
(US10239882, Example 26)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3ccccc3F)nc2n1
Show InChI InChI=1S/C18H20FN5O/c1-12-10-16(13-6-8-25-9-7-13)24-18(21-12)22-17(23-24)20-11-14-4-2-3-5-15(14)19/h2-5,10,13H,6-9,11H2,1H3,(H,20,23)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372217
PNG
(US10239882, Example 6)
Show SMILES CC(C)c1cc(C)nc2nc(NCc3ccc4CCCc4c3)nn12
Show InChI InChI=1S/C19H23N5/c1-12(2)17-9-13(3)21-19-22-18(23-24(17)19)20-11-14-7-8-15-5-4-6-16(15)10-14/h7-10,12H,4-6,11H2,1-3H3,(H,20,23)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372250
PNG
(US10239882, Example 86)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cccc(c3)C#N)nc2n1
Show InChI InChI=1S/C19H20N6O/c1-13-9-17(16-5-7-26-8-6-16)25-19(22-13)23-18(24-25)21-12-15-4-2-3-14(10-15)11-20/h2-4,9-10,16H,5-8,12H2,1H3,(H,21,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372246
PNG
(US10239882, Example 70)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3c(F)cncc3F)nc2n1
Show InChI InChI=1S/C17H18F2N6O/c1-10-6-15(11-2-4-26-5-3-11)25-17(22-10)23-16(24-25)21-7-12-13(18)8-20-9-14(12)19/h6,8-9,11H,2-5,7H2,1H3,(H,21,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372234
PNG
(US10239882, Example 45)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3ccc4OC(F)(F)Oc4c3)nc2n1
Show InChI InChI=1S/C19H19F2N5O3/c1-11-8-14(13-4-6-27-7-5-13)26-18(23-11)24-17(25-26)22-10-12-2-3-15-16(9-12)29-19(20,21)28-15/h2-3,8-9,13H,4-7,10H2,1H3,(H,22,25)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372243
PNG
(US10239882, Example 64)
Show SMILES COc1ccc(cc1)[C@@H](C)Nc1nc2nc(C)cc(C3CCOCC3)n2n1
Show InChI InChI=1/C20H25N5O2/c1-13-12-18(16-8-10-27-11-9-16)25-20(21-13)23-19(24-25)22-14(2)15-4-6-17(26-3)7-5-15/h4-7,12,14,16H,8-11H2,1-3H3,(H,22,24)/t14-/s2
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372216
PNG
(US10239882, Example 5)
Show SMILES Cc1cc(C2CCCC2)n2nc(NCc3ccc4CCCc4c3)nc2n1
Show InChI InChI=1S/C21H25N5/c1-14-11-19(17-5-2-3-6-17)26-21(23-14)24-20(25-26)22-13-15-9-10-16-7-4-8-18(16)12-15/h9-12,17H,2-8,13H2,1H3,(H,22,25)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372221
PNG
(US10239882, Example 16)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3ccc4OCCOc4c3)nc2n1
Show InChI InChI=1S/C20H23N5O3/c1-13-10-16(15-4-6-26-7-5-15)25-20(22-13)23-19(24-25)21-12-14-2-3-17-18(11-14)28-9-8-27-17/h2-3,10-11,15H,4-9,12H2,1H3,(H,21,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372222
PNG
(US10239882, Example 18)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(C4CCN(CC4)C(C)=O)n3n2)cc1
Show InChI InChI=1S/C21H26N6O2/c1-14-12-19(17-8-10-26(11-9-17)15(2)28)27-21(23-14)24-20(25-27)22-13-16-4-6-18(29-3)7-5-16/h4-7,12,17H,8-11,13H2,1-3H3,(H,22,25)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372235
PNG
(US10239882, Example 47)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3ccccc3C)nc2n1
Show InChI InChI=1S/C19H23N5O/c1-13-5-3-4-6-16(13)12-20-18-22-19-21-14(2)11-17(24(19)23-18)15-7-9-25-10-8-15/h3-6,11,15H,7-10,12H2,1-2H3,(H,20,23)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372239
PNG
(US10239882, Example 56)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3ccc(F)c(F)c3)nc2n1
Show InChI InChI=1S/C18H19F2N5O/c1-11-8-16(13-4-6-26-7-5-13)25-18(22-11)23-17(24-25)21-10-12-2-3-14(19)15(20)9-12/h2-3,8-9,13H,4-7,10H2,1H3,(H,21,24)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372240
PNG
(US10239882, Example 57)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3ccc(F)cc3)nc2n1
Show InChI InChI=1S/C18H20FN5O/c1-12-10-16(14-6-8-25-9-7-14)24-18(21-12)22-17(23-24)20-11-13-2-4-15(19)5-3-13/h2-5,10,14H,6-9,11H2,1H3,(H,20,23)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372242
PNG
(US10239882, Example 63)
Show SMILES Cc1nn(cc1CNc1nc2nc(C)cc(C3CC3)n2n1)-c1ccccc1
Show InChI InChI=1S/C20H21N7/c1-13-10-18(15-8-9-15)27-20(22-13)23-19(25-27)21-11-16-12-26(24-14(16)2)17-6-4-3-5-7-17/h3-7,10,12,15H,8-9,11H2,1-2H3,(H,21,25)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372247
PNG
(US10239882, Example 71)
Show SMILES Cc1nn(cc1CNc1nc2nc(C)cc(C3CCC3)n2n1)-c1ccccc1
Show InChI InChI=1S/C21H23N7/c1-14-11-19(16-7-6-8-16)28-21(23-14)24-20(26-28)22-12-17-13-27(25-15(17)2)18-9-4-3-5-10-18/h3-5,9-11,13,16H,6-8,12H2,1-2H3,(H,22,26)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372219
PNG
(US10239882, Example 11)
Show SMILES CCC(C)c1cc(C)nc2nc(NCc3ccc(OC)cc3)nn12
Show InChI InChI=1/C18H23N5O/c1-5-12(2)16-10-13(3)20-18-21-17(22-23(16)18)19-11-14-6-8-15(24-4)9-7-14/h6-10,12H,5,11H2,1-4H3,(H,19,22)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372230
PNG
(US10239882, Example 34)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(n3n2)C2(C)CCOCC2)cc1
Show InChI InChI=1S/C20H25N5O2/c1-14-12-17(20(2)8-10-27-11-9-20)25-19(22-14)23-18(24-25)21-13-15-4-6-16(26-3)7-5-15/h4-7,12H,8-11,13H2,1-3H3,(H,21,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372241
PNG
(US10239882, Example 58)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3cccc(F)c3)nc2n1
Show InChI InChI=1S/C18H20FN5O/c1-12-9-16(14-5-7-25-8-6-14)24-18(21-12)22-17(23-24)20-11-13-3-2-4-15(19)10-13/h2-4,9-10,14H,5-8,11H2,1H3,(H,20,23)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372245
PNG
(US10239882, Example 68)
Show SMILES Cc1cc(C2CCOCC2)n2nc(NCc3ccc(F)cc3F)nc2n1
Show InChI InChI=1S/C18H19F2N5O/c1-11-8-16(12-4-6-26-7-5-12)25-18(22-11)23-17(24-25)21-10-13-2-3-14(19)9-15(13)20/h2-3,8-9,12H,4-7,10H2,1H3,(H,21,24)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372255
PNG
(US10239882, Example 8)
Show SMILES CC(C)c1cc(C)nc2nc(NCc3ccccc3)nn12
Show InChI InChI=1S/C16H19N5/c1-11(2)14-9-12(3)18-16-19-15(20-21(14)16)17-10-13-7-5-4-6-8-13/h4-9,11H,10H2,1-3H3,(H,17,20)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372251
PNG
(US10239882, Example 2)
Show SMILES Cc1cc(C2CC2)n2nc(NCc3ccc4OCCc4c3)nc2n1
Show InChI InChI=1S/C18H19N5O/c1-11-8-15(13-3-4-13)23-18(20-11)21-17(22-23)19-10-12-2-5-16-14(9-12)6-7-24-16/h2,5,8-9,13H,3-4,6-7,10H2,1H3,(H,19,22)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372256
PNG
(US10239882, Example 10)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(C(C)C)n3n2)cc1
Show InChI InChI=1S/C17H21N5O/c1-11(2)15-9-12(3)19-17-20-16(21-22(15)17)18-10-13-5-7-14(23-4)8-6-13/h5-9,11H,10H2,1-4H3,(H,18,21)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372254
PNG
(US10239882, Example 7)
Show SMILES CC(C)c1cc(C)nc2nc(NCc3cccc(Cl)c3)nn12
Show InChI InChI=1S/C16H18ClN5/c1-10(2)14-7-11(3)19-16-20-15(21-22(14)16)18-9-12-5-4-6-13(17)8-12/h4-8,10H,9H2,1-3H3,(H,18,21)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372252
PNG
(US10239882, Example 3)
Show SMILES Cc1cc(C2CC2)n2nc(NCc3ccc4CCOc4c3)nc2n1
Show InChI InChI=1S/C18H19N5O/c1-11-8-15(13-4-5-13)23-18(20-11)21-17(22-23)19-10-12-2-3-14-6-7-24-16(14)9-12/h2-3,8-9,13H,4-7,10H2,1H3,(H,19,22)
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US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372259
PNG
(US10239882, Example 77)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(n3n2)C(C)(C)OC)cc1
Show InChI InChI=1S/C18H23N5O2/c1-12-10-15(18(2,3)25-5)23-17(20-12)21-16(22-23)19-11-13-6-8-14(24-4)9-7-13/h6-10H,11H2,1-5H3,(H,19,22)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372258
PNG
(US10239882, Example 69)
Show SMILES COc1ccc(cc1)[C@H](C)Nc1nc2nc(C)cc(C3CCOCC3)n2n1
Show InChI InChI=1/C20H25N5O2/c1-13-12-18(16-8-10-27-11-9-16)25-20(21-13)23-19(24-25)22-14(2)15-4-6-17(26-3)7-5-15/h4-7,12,14,16H,8-11H2,1-3H3,(H,22,24)/t14-/s2
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372253
PNG
(US10239882, Example 4)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(C4CC4)n3n2)cc1
Show InChI InChI=1S/C17H19N5O/c1-11-9-15(13-5-6-13)22-17(19-11)20-16(21-22)18-10-12-3-7-14(23-2)8-4-12/h3-4,7-9,13H,5-6,10H2,1-2H3,(H,18,21)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM372257
PNG
(US10239882, Example 12)
Show SMILES COc1ccc(CNc2nc3nc(C)cc(C4CCCO4)n3n2)cc1
Show InChI InChI=1/C18H21N5O2/c1-12-10-15(16-4-3-9-25-16)23-18(20-12)21-17(22-23)19-11-13-5-7-14(24-2)8-6-13/h5-8,10,16H,3-4,9,11H2,1-2H3,(H,19,22)
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...


US Patent US10239882 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%