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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340160 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340068 (4-(3-((S)-1-acryloylpiperidin-2-yl)-8- aminoimidaz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340098 ((S)-4-(8-amino-3-(1-(2-chloro pyrimidine-4-carbony...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340070 ((S)-4-(8-amino-3-(1-(2- chloropyrimidine-4- carbon...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340071 (4-(8-amino-3-((S)-1-((E)-4- methoxybut-2-enoyl)pip...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340072 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340076 ((S)-4-(8-amino-3-(1-(2- (trifluoromethyl)acryloyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340078 ((S)-4-(8-amino-3-(1- (cyanomethyl)pyrrolidin-2- yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340175 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340115 ((S)-4-(8-amino-3-(1-(N-methylbut- 2-ynamido)ethyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340179 ((S)-4-(8-amino-3-(1-(2- chloropyrimidine-4- carbon...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340181 ((S)-4-(3-(1-acryloylpiperidin-2-yl)-8- aminoimidaz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340183 ((R,E)-4-(8-amino-3-(4-(4- methoxybut-2-enoyl)morph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340184 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340193 ((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340187 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 550 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340189 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 550 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM340196 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 550 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM340071 (4-(8-amino-3-((S)-1-((E)-4- methoxybut-2-enoyl)pip...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 550 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM340084 (US10239883, Example 11 | US9758524, Example 11) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM340113 ((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM340123 (US10239883, Example 10 | US9758524, Example 10) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM340126 (US10239883, Example 14 | US9758524, Example 14) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM340139 (US10239883, Example 28 | US9758524, Example 28) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM340152 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM340162 ((S)-4-(8-amino-3-(1-but-2- ynoylpiperidin-2-yl)imi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM340119 (US10239883, Example 3 | US9758524, Example 127 | U...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM340195 ((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM340196 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM372277 (US10239883, Example 2) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340130 (US10239883, Example 18 | US9758524, Example 18) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340097 ((S)-4-(8-amino-3-(1-(2-chloro pyrimidine-4-carbony...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340069 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340070 ((S)-4-(8-amino-3-(1-(2- chloropyrimidine-4- carbon...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340169 ((S,E)-4-(8-amino-3-(1-(4- (dimethylamino)but-2- en...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340072 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340105 ((S)-4-(8-amino-3-(1-but-2- ynoylpiperidin-2-yl)imi...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340107 ((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340108 ((E)-4-(8-amino-3-(1-(4-methoxybut- 2-enoyl)azepan-...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340109 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)pyrro...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340111 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)pyrro...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340174 ((S)-4-(8-amino-3-(1-(2- chloropyrimidine-4- carbon...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340114 (4-(8-amino-3-(but-2- ynamidomethyl)imidazo[1,5- a]...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340182 ((S)-4-(8-amino-3-(1-(2- chloropyrimidine-4- carbon...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340191 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)pyrro...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM340160 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) | PDB UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 550 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM340118 (US10239883, Example 1 | US9758524, Example 1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Src enzyme (Millipore catalog #14-326), is diluted to 0.8 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM340082 (US10239883, Example 5 | US9758524, Example 5) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Src enzyme (Millipore catalog #14-326), is diluted to 0.8 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM340123 (US10239883, Example 10 | US9758524, Example 10) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Src enzyme (Millipore catalog #14-326), is diluted to 0.8 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ... | US Patent US10239883 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
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