BindingDB logo
myBDB logout

Patent code US10239887

Compile Data Set for Download or QSAR
Found 97 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372260
PNG
(2-[4-[[(3,4-Dimethylpyrimido[4',5':4,5]thieno[2,3-...)
Show SMILES Cc1nnc2sc3c(NCc4ccc(cc4)C(C)(C)O)ncnc3c2c1C
Show InChI InChI=1S/C20H21N5OS/c1-11-12(2)24-25-19-15(11)16-17(27-19)18(23-10-22-16)21-9-13-5-7-14(8-6-13)20(3,4)26/h5-8,10,26H,9H2,1-4H3,(H,21,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 52n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372273
PNG
(6-(3,4-dimethylpyrimido [4',5':4,5]thieno[2,3-c] p...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CC2(COC2)C1
Show InChI InChI=1S/C15H15N5OS/c1-8-9(2)18-19-14-10(8)11-12(22-14)13(17-7-16-11)20-3-15(4-20)5-21-6-15/h7H,3-6H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 123n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372274
PNG
(8-(3-(methoxymethyl) azetidin-1-yl)-3,4- dimethylp...)
Show SMILES COCC1CN(C1)c1ncnc2c1sc1nnc(C)c(C)c21
Show InChI InChI=1S/C15H17N5OS/c1-8-9(2)18-19-15-11(8)12-13(22-15)14(17-7-16-12)20-4-10(5-20)6-21-3/h7,10H,4-6H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 418n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372276
PNG
(4-(3,3-difluoropyrrolidin- 1-yl)-8-methylpyrido [3...)
Show SMILES Cc1cnc2sc3c(ncnc3c2c1)N1CCC(F)(F)C1
Show InChI InChI=1S/C14H12F2N4S/c1-8-4-9-10-11(21-13(9)17-5-8)12(19-7-18-10)20-3-2-14(15,16)6-20/h4-5,7H,2-3,6H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 377n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372285
PNG
(3,4-dimethyl-N-(1- phenylpyrrolidin-3-yl) pyrimido...)
Show SMILES Cc1nnc2sc3c(NC4CCN(C4)c4ccccc4)ncnc3c2c1C
Show InChI InChI=1/C20H20N6S/c1-12-13(2)24-25-20-16(12)17-18(27-20)19(22-11-21-17)23-14-8-9-26(10-14)15-6-4-3-5-7-15/h3-7,11,14H,8-10H2,1-2H3,(H,21,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372288
PNG
(N-(2-(4-methoxyphenyl) cyclopropyl)-3,4- dimethylp...)
Show SMILES COc1ccc(cc1)C1CC1Nc1ncnc2c1sc1nnc(C)c(C)c21
Show InChI InChI=1/C20H19N5OS/c1-10-11(2)24-25-20-16(10)17-18(27-20)19(22-9-21-17)23-15-8-14(15)12-4-6-13(26-3)7-5-12/h4-7,9,14-15H,8H2,1-3H3,(H,21,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372296
PNG
(1-(3,4-dimethylpyrimido [4',5':4,5]thieno[2,3-c] p...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CC(C)(O)C1
Show InChI InChI=1S/C14H15N5OS/c1-7-8(2)17-18-13-9(7)10-11(21-13)12(16-6-15-10)19-4-14(3,20)5-19/h6,20H,4-5H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 660n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372302
PNG
(8-chloro-N-(2,2- dimethylcyclopropyl)- 7,9-dimethy...)
Show SMILES Cc1nc2oc3c(NC4CC4(C)C)ncnc3c2c(C)c1Cl
Show InChI InChI=1/C16H17ClN4O/c1-7-10-12-13(22-15(10)20-8(2)11(7)17)14(19-6-18-12)21-9-5-16(9,3)4/h6,9H,5H2,1-4H3,(H,18,19,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 109n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372309
PNG
(8-chloro-N-isobutyl- 7,9-dimethyl- pyrido[3',2':4,...)
Show SMILES CC(C)CNc1ncnc2c1oc1nc(C)c(Cl)c(C)c21
Show InChI InChI=1S/C15H17ClN4O/c1-7(2)5-17-14-13-12(18-6-19-14)10-8(3)11(16)9(4)20-15(10)21-13/h6-7H,5H2,1-4H3,(H,17,18,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 601n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372310
PNG
(8-chloro-N-ethyl- 7,9-dimethyl- pyrido[3',2':4,5]f...)
Show SMILES CCNc1ncnc2c1oc1nc(C)c(Cl)c(C)c21
Show InChI InChI=1S/C13H13ClN4O/c1-4-15-12-11-10(16-5-17-12)8-6(2)9(14)7(3)18-13(8)19-11/h5H,4H2,1-3H3,(H,15,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.25E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372320
PNG
(2-[3-[[(7,9- dimethylpyrido[3',2':4,5]furo d[3,2-]...)
Show SMILES Cc1cc(C)c2c(n1)oc1c(NCc3cccc(c3)C(C)(C)O)ncnc21
Show InChI InChI=1S/C21H22N4O2/c1-12-8-13(2)25-20-16(12)17-18(27-20)19(24-11-23-17)22-10-14-6-5-7-15(9-14)21(3,4)26/h5-9,11,26H,10H2,1-4H3,(H,22,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.27E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372323
PNG
(N-[1-(2,5-dichloro-4- pyridyl)azetidin-3-yl]- 7,9-...)
Show SMILES Cc1cc(C)c2c(n1)oc1c(NC3CN(C3)c3cc(Cl)ncc3Cl)ncnc21
Show InChI InChI=1S/C19H16Cl2N6O/c1-9-3-10(2)25-19-15(9)16-17(28-19)18(24-8-23-16)26-11-6-27(7-11)13-4-14(21)22-5-12(13)20/h3-5,8,11H,6-7H2,1-2H3,(H,23,24,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.49E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372328
PNG
(2-[4-[[(3,4-dimethylpyrimido[4′,5′:4,5...)
Show SMILES Cc1nnc2oc3c(NCc4ccc(cc4)C(C)(C)O)ncnc3c2c1C
Show InChI InChI=1S/C20H21N5O2/c1-11-12(2)24-25-19-15(11)16-17(27-19)18(23-10-22-16)21-9-13-5-7-14(8-6-13)20(3,4)26/h5-8,10,26H,9H2,1-4H3,(H,21,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.29E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372336
PNG
(3,4-dimethyl-8-(2-oxa-6- azaspiro[3.3]heptan-6- yl...)
Show SMILES Cc1nnc2oc3c(ncnc3c2c1C)N1CC2(COC2)C1
Show InChI InChI=1S/C15H15N5O2/c1-8-9(2)18-19-14-10(8)11-12(22-14)13(17-7-16-11)20-3-15(4-20)5-21-6-15/h7H,3-6H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.84E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372265
PNG
(N-cyclobutyl-3,4- dimethylpyrimido[4',5':4,5] thie...)
Show SMILES Cc1nnc2sc3c(NC4CCC4)ncnc3c2c1C
Show InChI InChI=1S/C14H15N5S/c1-7-8(2)18-19-14-10(7)11-12(20-14)13(16-6-15-11)17-9-4-3-5-9/h6,9H,3-5H2,1-2H3,(H,15,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 83n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372267
PNG
(3,4-dimethyl-N-(1-(5- (trifluoromethyl) pyrimidin-...)
Show SMILES Cc1nnc2sc3c(NC4CN(C4)c4ncc(cn4)C(F)(F)F)ncnc3c2c1C
Show InChI InChI=1S/C18H15F3N8S/c1-8-9(2)27-28-16-12(8)13-14(30-16)15(25-7-24-13)26-11-5-29(6-11)17-22-3-10(4-23-17)18(19,20)21/h3-4,7,11H,5-6H2,1-2H3,(H,24,25,26)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 30n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372268
PNG
(8-(4- cyclopropylpiperazin- 1-yl)-3,4-dimethylpyri...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CCN(CC1)C1CC1
Show InChI InChI=1S/C17H20N6S/c1-10-11(2)20-21-17-13(10)14-15(24-17)16(19-9-18-14)23-7-5-22(6-8-23)12-3-4-12/h9,12H,3-8H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 616n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372270
PNG
(8-(3-azabicyclo[3.1.0] hexan-3-yl)-3,4- dimethylpy...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CC2CC2C1
Show InChI InChI=1/C15H15N5S/c1-7-8(2)18-19-15-11(7)12-13(21-15)14(17-6-16-12)20-4-9-3-10(9)5-20/h6,9-10H,3-5H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 21n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372272
PNG
(N-(2-methoxyethyl)- N,3,4-trimethylpyrimido [4',5'...)
Show SMILES COCCN(C)c1ncnc2c1sc1nnc(C)c(C)c21
Show InChI InChI=1S/C14H17N5OS/c1-8-9(2)17-18-14-10(8)11-12(21-14)13(16-7-15-11)19(3)5-6-20-4/h7H,5-6H2,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 846n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372279
PNG
(4-(azetidin-1-yl)-8- methylpyrido[3',2':4,5] thien...)
Show SMILES Cc1cnc2sc3c(ncnc3c2c1)N1CCC1
Show InChI InChI=1S/C13H12N4S/c1-8-5-9-10-11(18-13(9)14-6-8)12(16-7-15-10)17-3-2-4-17/h5-7H,2-4H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 807n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372279
PNG
(4-(azetidin-1-yl)-8- methylpyrido[3',2':4,5] thien...)
Show SMILES Cc1cnc2sc3c(ncnc3c2c1)N1CCC1
Show InChI InChI=1S/C13H12N4S/c1-8-5-9-10-11(18-13(9)14-6-8)12(16-7-15-10)17-3-2-4-17/h5-7H,2-4H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.50E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372281
PNG
(N-(1-(5-(trifluoromethyl) pyrimidin-2-yl)azetidin-...)
Show SMILES FC(F)(F)c1cnc(nc1)N1CC(C1)Nc1ncnc2c1sc1nccnc21
Show InChI InChI=1S/C16H11F3N8S/c17-16(18,19)8-3-22-15(23-4-8)27-5-9(6-27)26-13-12-10(24-7-25-13)11-14(28-12)21-2-1-20-11/h1-4,7,9H,5-6H2,(H,24,25,26)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.80E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372286
PNG
(3,4-dimethyl-8-(3- (pyridin-4-yl)azetidin- 1-yl)py...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CC(C1)c1ccncc1
Show InChI InChI=1S/C18H16N6S/c1-10-11(2)22-23-18-14(10)15-16(25-18)17(21-9-20-15)24-7-13(8-24)12-3-5-19-6-4-12/h3-6,9,13H,7-8H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 185n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372297
PNG
(1-(3-((3,4- dimethylpyrimido [4',5':4,5]thieno[2,3...)
Show SMILES CC(=O)N1CC(C1)Nc1ncnc2c1sc1nnc(C)c(C)c21
Show InChI InChI=1S/C15H16N6OS/c1-7-8(2)19-20-15-11(7)12-13(23-15)14(17-6-16-12)18-10-4-21(5-10)9(3)22/h6,10H,4-5H2,1-3H3,(H,16,17,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 53n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372298
PNG
(US10239887, Cpd. No. 36)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CC(=O)C1
Show InChI InChI=1S/C13H11N5OS/c1-6-7(2)16-17-13-9(6)10-11(20-13)12(15-5-14-10)18-3-8(19)4-18/h5H,3-4H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.00E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372306
PNG
(8-chloro-N,7,9-trimethyl- pyrido[3',2':4,5]furo[3,...)
Show SMILES CNc1ncnc2c1oc1nc(C)c(Cl)c(C)c21
Show InChI InChI=1S/C12H11ClN4O/c1-5-7-9-10(11(14-3)16-4-15-9)18-12(7)17-6(2)8(5)13/h4H,1-3H3,(H,14,15,16)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.69E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372312
PNG
(8-chloro-N-cyclobutyl- 7,9-dimethyl- pyrido[3',2':...)
Show SMILES Cc1nc2oc3c(NC4CCC4)ncnc3c2c(C)c1Cl
Show InChI InChI=1S/C15H15ClN4O/c1-7-10-12-13(21-15(10)19-8(2)11(7)16)14(18-6-17-12)20-9-4-3-5-9/h6,9H,3-5H2,1-2H3,(H,17,18,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 695n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372314
PNG
(8-chloro-N-[2-(3,4- difluorophenyl)cyclopropyl]- 7...)
Show SMILES Cc1nc2oc3c(NC4CC4c4ccc(F)c(F)c4)ncnc3c2c(C)c1Cl
Show InChI InChI=1/C20H15ClF2N4O/c1-8-15-17-18(28-20(15)26-9(2)16(8)21)19(25-7-24-17)27-14-6-11(14)10-3-4-12(22)13(23)5-10/h3-5,7,11,14H,6H2,1-2H3,(H,24,25,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 7.84E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372263
PNG
(3,4-dimethyl-N-(tetrahydro- 2H-pyran-4-yl) pyrimid...)
Show SMILES Cc1nnc2sc3c(NC4CCOCC4)ncnc3c2c1C
Show InChI InChI=1S/C15H17N5OS/c1-8-9(2)19-20-15-11(8)12-13(22-15)14(17-7-16-12)18-10-3-5-21-6-4-10/h7,10H,3-6H2,1-2H3,(H,16,17,18)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 521n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372269
PNG
(8-(azetidin-1-yl)-3,4- dimethylpyrimido [4',5':4,5...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CCC1
Show InChI InChI=1S/C13H13N5S/c1-7-8(2)16-17-13-9(7)10-11(19-13)12(15-6-14-10)18-4-3-5-18/h6H,3-5H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 405n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372281
PNG
(N-(1-(5-(trifluoromethyl) pyrimidin-2-yl)azetidin-...)
Show SMILES FC(F)(F)c1cnc(nc1)N1CC(C1)Nc1ncnc2c1sc1nccnc21
Show InChI InChI=1S/C16H11F3N8S/c17-16(18,19)8-3-22-15(23-4-8)27-5-9(6-27)26-13-12-10(24-7-25-13)11-14(28-12)21-2-1-20-11/h1-4,7,9H,5-6H2,(H,24,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372282
PNG
(8-(3,3-difluoroazetidin- 1-yl)-3,4-dimethylpyrimid...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CC(F)(F)C1
Show InChI InChI=1S/C13H11F2N5S/c1-6-7(2)18-19-12-8(6)9-10(21-12)11(17-5-16-9)20-3-13(14,15)4-20/h5H,3-4H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 426n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372286
PNG
(3,4-dimethyl-8-(3- (pyridin-4-yl)azetidin- 1-yl)py...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CC(C1)c1ccncc1
Show InChI InChI=1S/C18H16N6S/c1-10-11(2)22-23-18-14(10)15-16(25-18)17(21-9-20-15)24-7-13(8-24)12-3-5-19-6-4-12/h3-6,9,13H,7-8H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 64n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372311
PNG
(8-chloro-7,9-dimethyl- 4-pyrrolidin-1-yl- pyrido[3...)
Show SMILES Cc1nc2oc3c(ncnc3c2c(C)c1Cl)N1CCCC1
Show InChI InChI=1S/C15H15ClN4O/c1-8-10-12-13(21-15(10)19-9(2)11(8)16)14(18-7-17-12)20-5-3-4-6-20/h7H,3-6H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.53E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372322
PNG
(N-[1-(5-fluoropyrimidin-2- yl)azetidin-3-yl]-7,9-d...)
Show SMILES Cc1cc(C)c2c(n1)oc1c(NC3CN(C3)c3ncc(F)cn3)ncnc21
Show InChI InChI=1S/C18H16FN7O/c1-9-3-10(2)24-17-13(9)14-15(27-17)16(23-8-22-14)25-12-6-26(7-12)18-20-4-11(19)5-21-18/h3-5,8,12H,6-7H2,1-2H3,(H,22,23,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.11E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372327
PNG
(1-[4-[[(3,4- dimethylpyrimido [4',5':4,5]furo[2,3-...)
Show SMILES Cc1nnc2oc3c(NCc4ccc(cc4)C4(O)CCC4)ncnc3c2c1C
Show InChI InChI=1S/C21H21N5O2/c1-12-13(2)25-26-20-16(12)17-18(28-20)19(24-11-23-17)22-10-14-4-6-15(7-5-14)21(27)8-3-9-21/h4-7,11,27H,3,8-10H2,1-2H3,(H,22,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 862n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372338
PNG
(N-[(3-fluoro-4-methoxy- phenyl)methyl]-3,4-dimethy...)
Show SMILES COc1ccc(CNc2ncnc3c2oc2nnc(C)c(C)c32)cc1F
Show InChI InChI=1S/C18H16FN5O2/c1-9-10(2)23-24-18-14(9)15-16(26-18)17(22-8-21-15)20-7-11-4-5-13(25-3)12(19)6-11/h4-6,8H,7H2,1-3H3,(H,20,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.07E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372275
PNG
(8-methyl-4- (pyrrolidin-1-yl) pyrido[3',2':4,5]thi...)
Show SMILES Cc1cnc2sc3c(ncnc3c2c1)N1CCCC1
Show InChI InChI=1S/C14H14N4S/c1-9-6-10-11-12(19-14(10)15-7-9)13(17-8-16-11)18-4-2-3-5-18/h6-8H,2-5H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 161n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372276
PNG
(4-(3,3-difluoropyrrolidin- 1-yl)-8-methylpyrido [3...)
Show SMILES Cc1cnc2sc3c(ncnc3c2c1)N1CCC(F)(F)C1
Show InChI InChI=1S/C14H12F2N4S/c1-8-4-9-10-11(21-13(9)17-5-8)12(19-7-18-10)20-3-2-14(15,16)6-20/h4-5,7H,2-3,6H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372280
PNG
(6-(8-methylpyrido [3',2':4,5]thieno[3,2-d] pyrimid...)
Show SMILES Cc1cnc2sc3c(ncnc3c2c1)N1CC2(COC2)C1
Show InChI InChI=1S/C15H14N4OS/c1-9-2-10-11-12(21-14(10)16-3-9)13(18-8-17-11)19-4-15(5-19)6-20-7-15/h2-3,8H,4-7H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.15E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372289
PNG
(N-(3-fluoro-4- methoxybenzyl)-3,4- dimethylpyrimid...)
Show SMILES COc1ccc(CNc2ncnc3c2sc2nnc(C)c(C)c32)cc1F
Show InChI InChI=1S/C18H16FN5OS/c1-9-10(2)23-24-18-14(9)15-16(26-18)17(22-8-21-15)20-7-11-4-5-13(25-3)12(19)6-11/h4-6,8H,7H2,1-3H3,(H,20,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372294
PNG
(8-(3-(3-fluorophenoxy) azetidin-1-yl)-3,4- dimethy...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CC(C1)Oc1cccc(F)c1
Show InChI InChI=1S/C19H16FN5OS/c1-10-11(2)23-24-19-15(10)16-17(27-19)18(22-9-21-16)25-7-14(8-25)26-13-5-3-4-12(20)6-13/h3-6,9,14H,7-8H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.76E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372300
PNG
(8-chloro-N-cyclopropyl- 7,9-dimethyl-pyrido [3',2'...)
Show SMILES Cc1nc2oc3c(NC4CC4)ncnc3c2c(C)c1Cl
Show InChI InChI=1S/C14H13ClN4O/c1-6-9-11-12(20-14(9)18-7(2)10(6)15)13(17-5-16-11)19-8-3-4-8/h5,8H,3-4H2,1-2H3,(H,16,17,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 56.5n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372317
PNG
(8-chloro-7,9-dimethyl-N-[(2- methylpyrimidin-5- yl...)
Show SMILES Cc1ncc(CNc2ncnc3c2oc2nc(C)c(Cl)c(C)c32)cn1
Show InChI InChI=1S/C17H15ClN6O/c1-8-12-14-15(25-17(12)24-9(2)13(8)18)16(23-7-22-14)21-6-11-4-19-10(3)20-5-11/h4-5,7H,6H2,1-3H3,(H,21,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.19E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372326
PNG
(N-[1-(5-Fluoropyrimidin-2-yl)azetidin-3-yl]-3,4-di...)
Show SMILES Cc1nnc2oc3c(NC4CN(C4)c4ncc(cn4)C(F)(F)F)ncnc3c2c1C
Show InChI InChI=1S/C18H15F3N8O/c1-8-9(2)27-28-16-12(8)13-14(30-16)15(25-7-24-13)26-11-5-29(6-11)17-22-3-10(4-23-17)18(19,20)21/h3-4,7,11H,5-6H2,1-2H3,(H,24,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 284n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372261
PNG
(N,N,3,4-tetramethylpyrimido[4',5':4,5]thieno[2,3-c...)
Show SMILES CN(C)c1ncnc2c1sc1nnc(C)c(C)c21
Show InChI InChI=1S/C12H13N5S/c1-6-7(2)15-16-12-8(6)9-10(18-12)11(17(3)4)14-5-13-9/h5H,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 638n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372261
PNG
(N,N,3,4-tetramethylpyrimido[4',5':4,5]thieno[2,3-c...)
Show SMILES CN(C)c1ncnc2c1sc1nnc(C)c(C)c21
Show InChI InChI=1S/C12H13N5S/c1-6-7(2)15-16-12-8(6)9-10(18-12)11(17(3)4)14-5-13-9/h5H,1-4H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 724n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372262
PNG
(N-cyclohexyl-3,4- dimethylpyrimido[4',5':4,5] thie...)
Show SMILES Cc1nnc2sc3c(NC4CCCCC4)ncnc3c2c1C
Show InChI InChI=1S/C16H19N5S/c1-9-10(2)20-21-16-12(9)13-14(22-16)15(18-8-17-13)19-11-6-4-3-5-7-11/h8,11H,3-7H2,1-2H3,(H,17,18,19)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 836n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372278
PNG
(8-methyl-N-(1-(5- (trifluoromethyl) pyrimidin-2-yl...)
Show SMILES Cc1cnc2sc3c(NC4CN(C4)c4ncc(cn4)C(F)(F)F)ncnc3c2c1
Show InChI InChI=1S/C18H14F3N7S/c1-9-2-12-13-14(29-16(12)22-3-9)15(26-8-25-13)27-11-6-28(7-11)17-23-4-10(5-24-17)18(19,20)21/h2-5,8,11H,6-7H2,1H3,(H,25,26,27)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 424n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372291
PNG
(N-(4-(2-fluoropyridin- 3-yl)benzyl)-3,4- dimethylp...)
Show SMILES Cc1nnc2sc3c(NCc4ccc(cc4)-c4cccnc4F)ncnc3c2c1C
Show InChI InChI=1S/C22H17FN6S/c1-12-13(2)28-29-22-17(12)18-19(30-22)21(27-11-26-18)25-10-14-5-7-15(8-6-14)16-4-3-9-24-20(16)23/h3-9,11H,10H2,1-2H3,(H,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.05E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372293
PNG
(8-(3-(2-fluorophenoxy) azetidin-1-yl)-3,4- dimethy...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CC(C1)Oc1ccccc1F
Show InChI InChI=1S/C19H16FN5OS/c1-10-11(2)23-24-19-15(10)16-17(27-19)18(22-9-21-16)25-7-12(8-25)26-14-6-4-3-5-13(14)20/h3-6,9,12H,7-8H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.16E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372301
PNG
(2-[4-[[(8-chloro-7,9- dimethyl-pyrido[3',2':4,5] f...)
Show SMILES Cc1nc2oc3c(NCc4ccc(cc4)C(C)(C)O)ncnc3c2c(C)c1Cl
Show InChI InChI=1S/C21H21ClN4O2/c1-11-15-17-18(28-20(15)26-12(2)16(11)22)19(25-10-24-17)23-9-13-5-7-14(8-6-13)21(3,4)27/h5-8,10,27H,9H2,1-4H3,(H,23,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 110n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372304
PNG
(4-(azetidin-1-yl)-8- chloro-7,9-dimethyl- pyrido[3...)
Show SMILES Cc1nc2oc3c(ncnc3c2c(C)c1Cl)N1CCC1
Show InChI InChI=1S/C14H13ClN4O/c1-7-9-11-12(20-14(9)18-8(2)10(7)15)13(17-6-16-11)19-4-3-5-19/h6H,3-5H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 269n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372305
PNG
(8-chloro-N,N,7,9- tetramethyl-pyrido[3',2':4,5] fu...)
Show SMILES CN(C)c1ncnc2c1oc1nc(C)c(Cl)c(C)c21
Show InChI InChI=1S/C13H13ClN4O/c1-6-8-10-11(12(18(3)4)16-5-15-10)19-13(8)17-7(2)9(6)14/h5H,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.39E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372331
PNG
(N-cyclopropyl-3,4- dimethyl-pyrimido [4',5':4,5]fu...)
Show SMILES Cc1nnc2oc3c(NC4CC4)ncnc3c2c1C
Show InChI InChI=1S/C13H13N5O/c1-6-7(2)17-18-13-9(6)10-11(19-13)12(15-5-14-10)16-8-3-4-8/h5,8H,3-4H2,1-2H3,(H,14,15,16)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.31E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372335
PNG
(N-(3,3-difluorocyclobutyl)- 3,4-dimethyl-pyrimido ...)
Show SMILES Cc1nnc2oc3c(NC4CC(F)(F)C4)ncnc3c2c1C
Show InChI InChI=1S/C14H13F2N5O/c1-6-7(2)20-21-13-9(6)10-11(22-13)12(18-5-17-10)19-8-3-14(15,16)4-8/h5,8H,3-4H2,1-2H3,(H,17,18,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.75E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372266
PNG
(3,4-dimethyl-8-(pyrrolidin-1- yl)pyrimido[4',5':4,...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CCCC1
Show InChI InChI=1S/C14H15N5S/c1-8-9(2)17-18-14-10(8)11-12(20-14)13(16-7-15-11)19-5-3-4-6-19/h7H,3-6H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 75n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372272
PNG
(N-(2-methoxyethyl)- N,3,4-trimethylpyrimido [4',5'...)
Show SMILES COCCN(C)c1ncnc2c1sc1nnc(C)c(C)c21
Show InChI InChI=1S/C14H17N5OS/c1-8-9(2)17-18-14-10(8)11-12(21-14)13(16-7-15-11)19(3)5-6-20-4/h7H,5-6H2,1-4H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 927n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372278
PNG
(8-methyl-N-(1-(5- (trifluoromethyl) pyrimidin-2-yl...)
Show SMILES Cc1cnc2sc3c(NC4CN(C4)c4ncc(cn4)C(F)(F)F)ncnc3c2c1
Show InChI InChI=1S/C18H14F3N7S/c1-9-2-12-13-14(29-16(12)22-3-9)15(26-8-25-13)27-11-6-28(7-11)17-23-4-10(5-24-17)18(19,20)21/h2-5,8,11H,6-7H2,1H3,(H,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 674n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372284
PNG
(3,4-dimethyl-N-(1-(6- (trifluoromethyl) pyridin-3-...)
Show SMILES Cc1nnc2sc3c(NC4CN(C4)c4ccc(nc4)C(F)(F)F)ncnc3c2c1C
Show InChI InChI=1S/C19H16F3N7S/c1-9-10(2)27-28-18-14(9)15-16(30-18)17(25-8-24-15)26-11-6-29(7-11)12-3-4-13(23-5-12)19(20,21)22/h3-5,8,11H,6-7H2,1-2H3,(H,24,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372313
PNG
(8-chloro-N-cyclopentyl-7,9- dimethyl-pyrido[3',2':...)
Show SMILES Cc1nc2oc3c(NC4CCCC4)ncnc3c2c(C)c1Cl
Show InChI InChI=1S/C16H17ClN4O/c1-8-11-13-14(22-16(11)20-9(2)12(8)17)15(19-7-18-13)21-10-5-3-4-6-10/h7,10H,3-6H2,1-2H3,(H,18,19,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 593n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372315
PNG
(8-chloro-N-(cyclobutyl- methyl)-7,9-dimethyl- pyri...)
Show SMILES Cc1nc2oc3c(NCC4CCC4)ncnc3c2c(C)c1Cl
Show InChI InChI=1S/C16H17ClN4O/c1-8-11-13-14(22-16(11)21-9(2)12(8)17)15(20-7-19-13)18-6-10-4-3-5-10/h7,10H,3-6H2,1-2H3,(H,18,19,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.53E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372260
PNG
(2-[4-[[(3,4-Dimethylpyrimido[4',5':4,5]thieno[2,3-...)
Show SMILES Cc1nnc2sc3c(NCc4ccc(cc4)C(C)(C)O)ncnc3c2c1C
Show InChI InChI=1S/C20H21N5OS/c1-11-12(2)24-25-19-15(11)16-17(27-19)18(23-10-22-16)21-9-13-5-7-14(8-6-13)20(3,4)26/h5-8,10,26H,9H2,1-4H3,(H,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 23n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372262
PNG
(N-cyclohexyl-3,4- dimethylpyrimido[4',5':4,5] thie...)
Show SMILES Cc1nnc2sc3c(NC4CCCCC4)ncnc3c2c1C
Show InChI InChI=1S/C16H19N5S/c1-9-10(2)20-21-16-12(9)13-14(22-16)15(18-8-17-13)19-11-6-4-3-5-7-11/h8,11H,3-7H2,1-2H3,(H,17,18,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 724n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372263
PNG
(3,4-dimethyl-N-(tetrahydro- 2H-pyran-4-yl) pyrimid...)
Show SMILES Cc1nnc2sc3c(NC4CCOCC4)ncnc3c2c1C
Show InChI InChI=1S/C15H17N5OS/c1-8-9(2)19-20-15-11(8)12-13(22-15)14(17-7-16-12)18-10-3-5-21-6-4-10/h7,10H,3-6H2,1-2H3,(H,16,17,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 446n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372264
PNG
(3,4-dimethyl-8-(piperidin-1- yl)pyrimido[4',5':4,5...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CCCCC1
Show InChI InChI=1S/C15H17N5S/c1-9-10(2)18-19-15-11(9)12-13(21-15)14(17-8-16-12)20-6-4-3-5-7-20/h8H,3-7H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 120n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372270
PNG
(8-(3-azabicyclo[3.1.0] hexan-3-yl)-3,4- dimethylpy...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CC2CC2C1
Show InChI InChI=1/C15H15N5S/c1-7-8(2)18-19-15-11(7)12-13(21-15)14(17-6-16-12)20-4-9-3-10(9)5-20/h6,9-10H,3-5H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 36n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372271
PNG
(1-(3,4- dimethylpyrimido [4',5':4,5]thieno[2,3-c] ...)
Show SMILES CN(C)C1CCN(C1)c1ncnc2c1sc1nnc(C)c(C)c21
Show InChI InChI=1/C16H20N6S/c1-9-10(2)19-20-16-12(9)13-14(23-16)15(18-8-17-13)22-6-5-11(7-22)21(3)4/h8,11H,5-7H2,1-4H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 326n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372273
PNG
(6-(3,4-dimethylpyrimido [4',5':4,5]thieno[2,3-c] p...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CC2(COC2)C1
Show InChI InChI=1S/C15H15N5OS/c1-8-9(2)18-19-14-10(8)11-12(22-14)13(17-7-16-11)20-3-15(4-20)5-21-6-15/h7H,3-6H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 231n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372290
PNG
(3,4-dimethyl-8-(3- phenylpyrrolidin-1-yl) pyrimido...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CCC(C1)c1ccccc1
Show InChI InChI=1/C20H19N5S/c1-12-13(2)23-24-20-16(12)17-18(26-20)19(22-11-21-17)25-9-8-15(10-25)14-6-4-3-5-7-14/h3-7,11,15H,8-10H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.56E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372292
PNG
(8-(3-(4-fluorophenoxy) azetidin-1-yl)-3,4- dimethy...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CC(C1)Oc1ccc(F)cc1
Show InChI InChI=1S/C19H16FN5OS/c1-10-11(2)23-24-19-15(10)16-17(27-19)18(22-9-21-16)25-7-14(8-25)26-13-5-3-12(20)4-6-13/h3-6,9,14H,7-8H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.61E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372299
PNG
(8-chloro-N-(3,3-difluorocyclobutyl)-7,9-dimethyl-p...)
Show SMILES Cc1nc2oc3c(NC4CC(F)(F)C4)ncnc3c2c(C)c1Cl
Show InChI InChI=1S/C15H13ClF2N4O/c1-6-9-11-12(23-14(9)21-7(2)10(6)16)13(20-5-19-11)22-8-3-15(17,18)4-8/h5,8H,3-4H2,1-2H3,(H,19,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 406n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372303
PNG
(8-chloro-N- (2-ethylcyclopropyl)-7,9- dimethyl-pyr...)
Show SMILES CCC1CC1Nc1ncnc2c1oc1nc(C)c(Cl)c(C)c21
Show InChI InChI=1/C16H17ClN4O/c1-4-9-5-10(9)21-15-14-13(18-6-19-15)11-7(2)12(17)8(3)20-16(11)22-14/h6,9-10H,4-5H2,1-3H3,(H,18,19,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 324n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372324
PNG
(N-[2-(3,4-dichloro- phenyl)cyclopropyl]-7,9- dimet...)
Show SMILES Cc1cc(C)c2c(n1)oc1c(NC3CC3c3ccc(F)c(F)c3)ncnc21
Show InChI InChI=1/C20H16F2N4O/c1-9-5-10(2)25-20-16(9)17-18(27-20)19(24-8-23-17)26-15-7-12(15)11-3-4-13(21)14(22)6-11/h3-6,8,12,15H,7H2,1-2H3,(H,23,24,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.38E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372329
PNG
(1-[3-[[(3,4- dimethylpyrimido [4',5':4,5]furo[2,3-...)
Show SMILES Cc1nnc2oc3c(NCc4cccc(c4)C4(O)CCC4)ncnc3c2c1C
Show InChI InChI=1S/C21H21N5O2/c1-12-13(2)25-26-20-16(12)17-18(28-20)19(24-11-23-17)22-10-14-5-3-6-15(9-14)21(27)7-4-8-21/h3,5-6,9,11,27H,4,7-8,10H2,1-2H3,(H,22,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.36E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372330
PNG
(2-[3-[[(3,4- dimethylpyrimido [4',5':4,5]furo[2,3-...)
Show SMILES Cc1nnc2oc3c(NCc4cccc(c4)C(C)(C)O)ncnc3c2c1C
Show InChI InChI=1S/C20H21N5O2/c1-11-12(2)24-25-19-15(11)16-17(27-19)18(23-10-22-16)21-9-13-6-5-7-14(8-13)20(3,4)26/h5-8,10,26H,9H2,1-4H3,(H,21,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.70E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372332
PNG
(N-cyclobutyl-3,4- dimethyl-pyrimido [4',5':4,5]fur...)
Show SMILES Cc1nnc2oc3c(NC4CCC4)ncnc3c2c1C
Show InChI InChI=1S/C14H15N5O/c1-7-8(2)18-19-14-10(7)11-12(20-14)13(16-6-15-11)17-9-4-3-5-9/h6,9H,3-5H2,1-2H3,(H,15,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.53E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372333
PNG
(N-cyclopentyl-3,4- dimethyl-pyrimido [4',5':4,5]fu...)
Show SMILES Cc1nnc2oc3c(NC4CCCC4)ncnc3c2c1C
Show InChI InChI=1S/C15H17N5O/c1-8-9(2)19-20-15-11(8)12-13(21-15)14(17-7-16-12)18-10-5-3-4-6-10/h7,10H,3-6H2,1-2H3,(H,16,17,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 818n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372337
PNG
(2-[5-[[(3,4- dimethylpyrimido [4',5':4,5]furo[2,3-...)
Show SMILES Cc1nnc2oc3c(NCc4ccc(nc4)C(C)(C)O)ncnc3c2c1C
Show InChI InChI=1S/C19H20N6O2/c1-10-11(2)24-25-18-14(10)15-16(27-18)17(23-9-22-15)21-8-12-5-6-13(20-7-12)19(3,4)26/h5-7,9,26H,8H2,1-4H3,(H,21,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 9.16E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372264
PNG
(3,4-dimethyl-8-(piperidin-1- yl)pyrimido[4',5':4,5...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CCCCC1
Show InChI InChI=1S/C15H17N5S/c1-9-10(2)18-19-15-11(9)12-13(21-15)14(17-8-16-12)20-6-4-3-5-7-20/h8H,3-7H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 215n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372265
PNG
(N-cyclobutyl-3,4- dimethylpyrimido[4',5':4,5] thie...)
Show SMILES Cc1nnc2sc3c(NC4CCC4)ncnc3c2c1C
Show InChI InChI=1S/C14H15N5S/c1-7-8(2)18-19-14-10(7)11-12(20-14)13(16-6-15-11)17-9-4-3-5-9/h6,9H,3-5H2,1-2H3,(H,15,16,17)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 112n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372266
PNG
(3,4-dimethyl-8-(pyrrolidin-1- yl)pyrimido[4',5':4,...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CCCC1
Show InChI InChI=1S/C14H15N5S/c1-8-9(2)17-18-14-10(8)11-12(20-14)13(16-7-15-11)19-5-3-4-6-19/h7H,3-6H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 48n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372267
PNG
(3,4-dimethyl-N-(1-(5- (trifluoromethyl) pyrimidin-...)
Show SMILES Cc1nnc2sc3c(NC4CN(C4)c4ncc(cn4)C(F)(F)F)ncnc3c2c1C
Show InChI InChI=1S/C18H15F3N8S/c1-8-9(2)27-28-16-12(8)13-14(30-16)15(25-7-24-13)26-11-5-29(6-11)17-22-3-10(4-23-17)18(19,20)21/h3-4,7,11H,5-6H2,1-2H3,(H,24,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 251n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372268
PNG
(8-(4- cyclopropylpiperazin- 1-yl)-3,4-dimethylpyri...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CCN(CC1)C1CC1
Show InChI InChI=1S/C17H20N6S/c1-10-11(2)20-21-17-13(10)14-15(24-17)16(19-9-18-14)23-7-5-22(6-8-23)12-3-4-12/h9,12H,3-8H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 700n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372269
PNG
(8-(azetidin-1-yl)-3,4- dimethylpyrimido [4',5':4,5...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CCC1
Show InChI InChI=1S/C13H13N5S/c1-7-8(2)16-17-13-9(7)10-11(19-13)12(15-6-14-10)18-4-3-5-18/h6H,3-5H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 351n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372271
PNG
(1-(3,4- dimethylpyrimido [4',5':4,5]thieno[2,3-c] ...)
Show SMILES CN(C)C1CCN(C1)c1ncnc2c1sc1nnc(C)c(C)c21
Show InChI InChI=1/C16H20N6S/c1-9-10(2)19-20-16-12(9)13-14(23-16)15(18-8-17-13)22-6-5-11(7-22)21(3)4/h8,11H,5-7H2,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 257n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372274
PNG
(8-(3-(methoxymethyl) azetidin-1-yl)-3,4- dimethylp...)
Show SMILES COCC1CN(C1)c1ncnc2c1sc1nnc(C)c(C)c21
Show InChI InChI=1S/C15H17N5OS/c1-8-9(2)18-19-15-11(8)12-13(22-15)14(17-7-16-12)20-4-10(5-20)6-21-3/h7,10H,4-6H2,1-3H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 883n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372275
PNG
(8-methyl-4- (pyrrolidin-1-yl) pyrido[3',2':4,5]thi...)
Show SMILES Cc1cnc2sc3c(ncnc3c2c1)N1CCCC1
Show InChI InChI=1S/C14H14N4S/c1-9-6-10-11-12(19-14(10)15-7-9)13(17-8-16-11)18-4-2-3-5-18/h6-8H,2-5H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372280
PNG
(6-(8-methylpyrido [3',2':4,5]thieno[3,2-d] pyrimid...)
Show SMILES Cc1cnc2sc3c(ncnc3c2c1)N1CC2(COC2)C1
Show InChI InChI=1S/C15H14N4OS/c1-9-2-10-11-12(21-14(10)16-3-9)13(18-8-17-11)19-4-15(5-19)6-20-7-15/h2-3,8H,4-7H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 456n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372287
PNG
(N-cyclopropyl- 3,4-dimethylpyrimido [4',5':4,5]thi...)
Show SMILES Cc1nnc2sc3c(NC4CC4)ncnc3c2c1C
Show InChI InChI=1S/C13H13N5S/c1-6-7(2)17-18-13-9(6)10-11(19-13)12(15-5-14-10)16-8-3-4-8/h5,8H,3-4H2,1-2H3,(H,14,15,16)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 468n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372295
PNG
(3,4-dimethyl-8-(3- phenoxyazetidin-1-yl) pyrimido[...)
Show SMILES Cc1nnc2sc3c(ncnc3c2c1C)N1CC(C1)Oc1ccccc1
Show InChI InChI=1S/C19H17N5OS/c1-11-12(2)22-23-19-15(11)16-17(26-19)18(21-10-20-16)24-8-14(9-24)25-13-6-4-3-5-7-13/h3-7,10,14H,8-9H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.43E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372307
PNG
(8-chloro-7,9-dimethyl-N- propyl-pyrido[3',2':4,5]f...)
Show SMILES CCCNc1ncnc2c1oc1nc(C)c(Cl)c(C)c21
Show InChI InChI=1S/C14H15ClN4O/c1-4-5-16-13-12-11(17-6-18-13)9-7(2)10(15)8(3)19-14(9)20-12/h6H,4-5H2,1-3H3,(H,16,17,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 358n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372316
PNG
(8-chloro-N-(3- methoxypropyl)-7,9- dimethyl-pyrido...)
Show SMILES COCCCNc1ncnc2c1oc1nc(C)c(Cl)c(C)c21
Show InChI InChI=1S/C15H17ClN4O2/c1-8-10-12-13(22-15(10)20-9(2)11(8)16)14(19-7-18-12)17-5-4-6-21-3/h7H,4-6H2,1-3H3,(H,17,18,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 365n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372318
PNG
(N-Cyclobutyl-7,9-dimethyl-pyrido[3′,2′...)
Show SMILES Cc1cc(C)c2c(n1)oc1c(NC3CCC3)ncnc21
Show InChI InChI=1S/C15H16N4O/c1-8-6-9(2)18-15-11(8)12-13(20-15)14(17-7-16-12)19-10-4-3-5-10/h6-7,10H,3-5H2,1-2H3,(H,16,17,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.59E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372319
PNG
(7,9-dimethyl-4-(2-oxa-6- azaspiro[3.3]heptan-6- yl...)
Show SMILES Cc1cc(C)c2c(n1)oc1c(ncnc21)N1CC2(COC2)C1
Show InChI InChI=1S/C16H16N4O2/c1-9-3-10(2)19-15-11(9)12-13(22-15)14(18-8-17-12)20-4-16(5-20)6-21-7-16/h3,8H,4-7H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.37E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372325
PNG
(N-cyclopropyl-7,9-dimethyl- pyrido[3',2':4,5]furo[...)
Show SMILES Cc1cc(C)c2c(n1)oc1c(NC3CC3)ncnc21
Show InChI InChI=1S/C14H14N4O/c1-7-5-8(2)17-14-10(7)11-12(19-14)13(16-6-15-11)18-9-3-4-9/h5-6,9H,3-4H2,1-2H3,(H,15,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.60E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372334
PNG
(3,4-dimethyl-N-(2- oxaspiro[3.3]heptan-6- yl)pyrim...)
Show SMILES Cc1nnc2oc3c(NC4CC5(COC5)C4)ncnc3c2c1C
Show InChI InChI=1S/C16H17N5O2/c1-8-9(2)20-21-15-11(8)12-13(23-15)14(18-7-17-12)19-10-3-16(4-10)5-22-6-16/h7,10H,3-6H2,1-2H3,(H,17,18,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%