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Found 25 Enz. Inhib. hit(s) with all data for entry = 2592
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113468(CHEMBL3603915 | US10246432, Example 15 | US1058411...)
Affinity DataKi:  0.501nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataKi:  0.537nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113477(CHEMBL3603924 | US10246432, Example 3 | US10584111...)
Affinity DataKi:  0.692nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113468(CHEMBL3603915 | US10246432, Example 15 | US1058411...)
Affinity DataKi:  0.832nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113479(CHEMBL3603926 | US10246432, Example 22 | US1058411...)
Affinity DataKi:  0.891nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113473(CHEMBL3603920 | US10246432, Example 1 | US10584111...)
Affinity DataKi:  1.23nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113475(CHEMBL3603922 | US10246432, Example 18 | US1058411...)
Affinity DataKi:  1.66nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113478(CHEMBL3603925 | US10246432, Example 20 | US1058411...)
Affinity DataKi:  1.70nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372982(3-methyl-5-[6-(5- | US10246432, Example 23 | US105...)
Affinity DataKi:  2.14nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113474(CHEMBL3603921 | US10246432, Example 19 | US1058411...)
Affinity DataKi:  2.45nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372983(3-[6-(5-fluoropyridin-2- | US10246432, Example 24 ...)
Affinity DataKi:  2.69nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113467(CHEMBL3603914 | US10246432, Example 14 | US1058411...)
Affinity DataKi:  2.75nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372963(3-methyl-5-[6-(pyridin- | US10246432, Example 4 | ...)
Affinity DataKi:  2.75nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113472(CHEMBL3603919 | US10246432, Example 2 | US10584111...)
Affinity DataKi:  3.02nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113467(CHEMBL3603914 | US10246432, Example 14 | US1058411...)
Affinity DataKi:  3.98nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113466(CHEMBL3603913 | US10246432, Example 13 | US1058411...)
Affinity DataKi:  4.07nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372969(3-chloro-4-fluoro-5-[4- | US10246432, Example 10 |...)
Affinity DataKi:  4.27nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372984(3-[6-(5-fluoropyridin-2- | US10246432, Example 25 ...)
Affinity DataKi:  4.27nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372965(3-(4,4′-bipyrimidin-6-yl)-5-chlorobenzonitri...)
Affinity DataKi:  5.37nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113466(CHEMBL3603913 | US10246432, Example 13 | US1058411...)
Affinity DataKi:  5.75nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372975(3-(fluoromethyl)-5-[6- | US10246432, Example 16 | ...)
Affinity DataKi:  6.76nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372970(3-chloro-4-fluoro-5-[2- | US10246432, Example 11 |...)
Affinity DataKi:  6.92nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113480(CHEMBL3603927 | US10246432, Example 5 | US10584111...)
Affinity DataKi:  9.77nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372971(3-chloro-4-fluoro-5-[6- | US10246432, Example 12 |...)
Affinity DataKi:  10nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372980(5-[6-(pyridin-2- | US10246432, Example 21 | US1058...)
Affinity DataKi:  10.5nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent