BindingDB logo
myBDB logout

Patent code US10246442

Compile Data Set for Download or QSAR
Found 135 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373616
PNG
(1-(6-(4-Chlorophenoxy)-4-(phenylamino)quinazolin-2...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(Nc2ccccc2)c2cc(Oc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C24H16ClN5O3/c25-16-6-8-18(9-7-16)33-19-10-11-21-20(12-19)22(27-17-4-2-1-3-5-17)29-24(28-21)30-14-15(13-26-30)23(31)32/h1-14H,(H,31,32)(H,27,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373637
PNG
(1-(4-(Diethylamino)-7-phenoxyquinazolin-2-yl)-1H-p...)
Show SMILES CCN(CC)c1nc(nc2cc(Oc3ccccc3)ccc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H21N5O3/c1-3-26(4-2)20-18-11-10-17(30-16-8-6-5-7-9-16)12-19(18)24-22(25-20)27-14-15(13-23-27)21(28)29/h5-14H,3-4H2,1-2H3,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373609
PNG
(1-(6-(4-Chlorophenoxy)-4-(piperidin-1-yl)quinazoli...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCCC2)c2cc(Oc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C23H20ClN5O3/c24-16-4-6-17(7-5-16)32-18-8-9-20-19(12-18)21(28-10-2-1-3-11-28)27-23(26-20)29-14-15(13-25-29)22(30)31/h4-9,12-14H,1-3,10-11H2,(H,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 25.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373612
PNG
(1-(4-(Azepan-1-yl)-6-(4-chlorophenoxy)quinazolin-2...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCCCC2)c2cc(Oc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C24H22ClN5O3/c25-17-5-7-18(8-6-17)33-19-9-10-21-20(13-19)22(29-11-3-1-2-4-12-29)28-24(27-21)30-15-16(14-26-30)23(31)32/h5-10,13-15H,1-4,11-12H2,(H,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373563
PNG
(1-(4-Amino-6-cyclohexylquinazolin-2-yl)-1H-pyrazol...)
Show SMILES Nc1nc(nc2ccc(cc12)C1CCCCC1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C18H19N5O2/c19-16-14-8-12(11-4-2-1-3-5-11)6-7-15(14)21-18(22-16)23-10-13(9-20-23)17(24)25/h6-11H,1-5H2,(H,24,25)(H2,19,21,22)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373610
PNG
(1-(6-(4-Chlorophenoxy)-4-((cyclohexylmethyl)amino)...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NCC2CCCCC2)c2cc(Oc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C25H24ClN5O3/c26-18-6-8-19(9-7-18)34-20-10-11-22-21(12-20)23(27-13-16-4-2-1-3-5-16)30-25(29-22)31-15-17(14-28-31)24(32)33/h6-12,14-16H,1-5,13H2,(H,32,33)(H,27,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373661
PNG
(1-(6-(Cyclohexyloxy)-4-(diethylamino)-7-fluoroquin...)
Show SMILES CCN(CC)c1nc(nc2cc(F)c(OC3CCCCC3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H26FN5O3/c1-3-27(4-2)20-16-10-19(31-15-8-6-5-7-9-15)17(23)11-18(16)25-22(26-20)28-13-14(12-24-28)21(29)30/h10-13,15H,3-9H2,1-2H3,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373668
PNG
(1-(6-(Cyclohexyloxy)-4-(diethylamino)-7-chloroquin...)
Show SMILES CCN(CC)c1nc(nc2cc(Cl)c(OC3CCCCC3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H26ClN5O3/c1-3-27(4-2)20-16-10-19(31-15-8-6-5-7-9-15)17(23)11-18(16)25-22(26-20)28-13-14(12-24-28)21(29)30/h10-13,15H,3-9H2,1-2H3,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373589
PNG
(1-(4-(Diethylamino)-6-phenylquinazolin-2-yl)-1H-py...)
Show SMILES CCN(CC)c1nc(nc2ccc(cc12)-c1ccccc1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H21N5O2/c1-3-26(4-2)20-18-12-16(15-8-6-5-7-9-15)10-11-19(18)24-22(25-20)27-14-17(13-23-27)21(28)29/h5-14H,3-4H2,1-2H3,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373667
PNG
(1-(6-(Cyclohexyloxy)-4-(dimethylamino)-7-chloroqui...)
Show SMILES CN(C)c1nc(nc2cc(Cl)c(OC3CCCCC3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C20H22ClN5O3/c1-25(2)18-14-8-17(29-13-6-4-3-5-7-13)15(21)9-16(14)23-20(24-18)26-11-12(10-22-26)19(27)28/h8-11,13H,3-7H2,1-2H3,(H,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373543
PNG
(1-[6-(2,6-Dimethyl-phenoxy)-7-fluoro-4-pyrrolidin-...)
Show SMILES Cc1cccc(C)c1Oc1cc2c(nc(nc2cc1F)-n1cc(cn1)C(O)=O)N1CCCC1
Show InChI InChI=1S/C24H22FN5O3/c1-14-6-5-7-15(2)21(14)33-20-10-17-19(11-18(20)25)27-24(28-22(17)29-8-3-4-9-29)30-13-16(12-26-30)23(31)32/h5-7,10-13H,3-4,8-9H2,1-2H3,(H,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373676
PNG
(1-(4-(Ethyl(methyl)amino)-7-chloro-6-isopropylquin...)
Show SMILES CCN(C)c1nc(nc2cc(Cl)c(cc12)C(C)C)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C18H20ClN5O2/c1-5-23(4)16-13-6-12(10(2)3)14(19)7-15(13)21-18(22-16)24-9-11(8-20-24)17(25)26/h6-10H,5H2,1-4H3,(H,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373627
PNG
(1-(4-(Dimethylamino)-7-phenoxyquinazolin-2-yl)-1H-...)
Show SMILES CN(C)c1nc(nc2cc(Oc3ccccc3)ccc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C20H17N5O3/c1-24(2)18-16-9-8-15(28-14-6-4-3-5-7-14)10-17(16)22-20(23-18)25-12-13(11-21-25)19(26)27/h3-12H,1-2H3,(H,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373611
PNG
(1-(6-(4-chlorophenoxy)-4-(4-cyanopiperidin-1-yl)qu...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCC(CC2)C#N)c2cc(Oc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C24H19ClN6O3/c25-17-1-3-18(4-2-17)34-19-5-6-21-20(11-19)22(30-9-7-15(12-26)8-10-30)29-24(28-21)31-14-16(13-27-31)23(32)33/h1-6,11,13-15H,7-10H2,(H,32,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373544
PNG
(1-[6-(2,6-Dimethyl-phenoxy)-7-fluoro-4-phenylamino...)
Show SMILES Cc1cccc(C)c1Oc1cc2c(Nc3ccccc3)nc(nc2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C26H20FN5O3/c1-15-7-6-8-16(2)23(15)35-22-11-19-21(12-20(22)27)30-26(32-14-17(13-28-32)25(33)34)31-24(19)29-18-9-4-3-5-10-18/h3-14H,1-2H3,(H,33,34)(H,29,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373673
PNG
(1-(4-(Dimethylamino)-7-chloro-6-isopropylquinazoli...)
Show SMILES CC(C)c1cc2c(nc(nc2cc1Cl)-n1cc(cn1)C(O)=O)N(C)C
Show InChI InChI=1S/C17H18ClN5O2/c1-9(2)11-5-12-14(6-13(11)18)20-17(21-15(12)22(3)4)23-8-10(7-19-23)16(24)25/h5-9H,1-4H3,(H,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373679
PNG
(1-(6-(Cyclohexyloxy)-4-(dimethylamino)quinazolin-2...)
Show SMILES CN(C)c1nc(nc2ccc(OC3CCCCC3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C20H23N5O3/c1-24(2)18-16-10-15(28-14-6-4-3-5-7-14)8-9-17(16)22-20(23-18)25-12-13(11-21-25)19(26)27/h8-12,14H,3-7H2,1-2H3,(H,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373550
PNG
(1-[6-(2,6-Dimethyl-phenoxy)-4-dipropylamino-7-fluo...)
Show SMILES CCCN(CCC)c1nc(nc2cc(F)c(Oc3c(C)cccc3C)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C26H28FN5O3/c1-5-10-31(11-6-2)24-19-12-22(35-23-16(3)8-7-9-17(23)4)20(27)13-21(19)29-26(30-24)32-15-18(14-28-32)25(33)34/h7-9,12-15H,5-6,10-11H2,1-4H3,(H,33,34)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373631
PNG
(1-(7-Phenoxy-4-(pyrrolidin-1-yl)quinazolin-2-yl)-1...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCC2)c2ccc(Oc3ccccc3)cc2n1
Show InChI InChI=1S/C22H19N5O3/c28-21(29)15-13-23-27(14-15)22-24-19-12-17(30-16-6-2-1-3-7-16)8-9-18(19)20(25-22)26-10-4-5-11-26/h1-3,6-9,12-14H,4-5,10-11H2,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373675
PNG
(1-(7-Chloro-6-isopropyl-4-(pyrrolidin-1-yl)quinazo...)
Show SMILES CC(C)c1cc2c(nc(nc2cc1Cl)-n1cc(cn1)C(O)=O)N1CCCC1
Show InChI InChI=1S/C19H20ClN5O2/c1-11(2)13-7-14-16(8-15(13)20)22-19(23-17(14)24-5-3-4-6-24)25-10-12(9-21-25)18(26)27/h7-11H,3-6H2,1-2H3,(H,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM50446891
PNG
(CHEMBL3115314 | US10246442, Example 61)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCC2)c2cc(Oc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C22H18ClN5O3/c23-15-3-5-16(6-4-15)31-17-7-8-19-18(11-17)20(27-9-1-2-10-27)26-22(25-19)28-13-14(12-24-28)21(29)30/h3-8,11-13H,1-2,9-10H2,(H,29,30)
PDB

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
US Patent
n/an/a 50.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373622
PNG
(1-(4-(Diethylamino)-6-phenoxyquinazolin-2-yl)-1H-p...)
Show SMILES CCN(CC)c1nc(nc2ccc(Oc3ccccc3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H21N5O3/c1-3-26(4-2)20-18-12-17(30-16-8-6-5-7-9-16)10-11-19(18)24-22(25-20)27-14-15(13-23-27)21(28)29/h5-14H,3-4H2,1-2H3,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373662
PNG
(1-(6-(Cyclohexyloxy)-7-fluoro-4-(pyrrolidin-1-yl)q...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCC2)c2cc(OC3CCCCC3)c(F)cc2n1
Show InChI InChI=1S/C22H24FN5O3/c23-17-11-18-16(10-19(17)31-15-6-2-1-3-7-15)20(27-8-4-5-9-27)26-22(25-18)28-13-14(12-24-28)21(29)30/h10-13,15H,1-9H2,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373684
PNG
(1-(6-(Cyclohexyloxy)-4-(ethyl(methyl)amino)quinazo...)
Show SMILES CCN(C)c1nc(nc2ccc(OC3CCCCC3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C21H25N5O3/c1-3-25(2)19-17-11-16(29-15-7-5-4-6-8-15)9-10-18(17)23-21(24-19)26-13-14(12-22-26)20(27)28/h9-13,15H,3-8H2,1-2H3,(H,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373569
PNG
(1-(6-Cyclohexyl-4-(phenylamino)quinazolin-2-yl)-1H...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(Nc2ccccc2)c2cc(ccc2n1)C1CCCCC1
Show InChI InChI=1S/C24H23N5O2/c30-23(31)18-14-25-29(15-18)24-27-21-12-11-17(16-7-3-1-4-8-16)13-20(21)22(28-24)26-19-9-5-2-6-10-19/h2,5-6,9-16H,1,3-4,7-8H2,(H,30,31)(H,26,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373585
PNG
(1-(4-(Ethyl(methyl)amino)-6-phenylquinazolin-2-yl)...)
Show SMILES CCN(C)c1nc(nc2ccc(cc12)-c1ccccc1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C21H19N5O2/c1-3-25(2)19-17-11-15(14-7-5-4-6-8-14)9-10-18(17)23-21(24-19)26-13-16(12-22-26)20(27)28/h4-13H,3H2,1-2H3,(H,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373605
PNG
(1-(6-(4-Chlorophenoxy)-4-(diethylamino)quinazolin-...)
Show SMILES CCN(CC)c1nc(nc2ccc(Oc3ccc(Cl)cc3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H20ClN5O3/c1-3-27(4-2)20-18-11-17(31-16-7-5-15(23)6-8-16)9-10-19(18)25-22(26-20)28-13-14(12-24-28)21(29)30/h5-13H,3-4H2,1-2H3,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373568
PNG
(1-(6-Cyclohexyl-4-(diethylamino)quinazolin-2-yl)-1...)
Show SMILES CCN(CC)c1nc(nc2ccc(cc12)C1CCCCC1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H27N5O2/c1-3-26(4-2)20-18-12-16(15-8-6-5-7-9-15)10-11-19(18)24-22(25-20)27-14-17(13-23-27)21(28)29/h10-15H,3-9H2,1-2H3,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373586
PNG
(1-(6-Phenyl-4-(pyrrolidin-1-yl)quinazolin-2-yl)-1H...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCC2)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C22H19N5O2/c28-21(29)17-13-23-27(14-17)22-24-19-9-8-16(15-6-2-1-3-7-15)12-18(19)20(25-22)26-10-4-5-11-26/h1-3,6-9,12-14H,4-5,10-11H2,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373613
PNG
(1-(6-(4-Chlorophenoxy)-4-thiomorpholinoquinazolin-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCSCC2)c2cc(Oc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C22H18ClN5O3S/c23-15-1-3-16(4-2-15)31-17-5-6-19-18(11-17)20(27-7-9-32-10-8-27)26-22(25-19)28-13-14(12-24-28)21(29)30/h1-6,11-13H,7-10H2,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373581
PNG
(1-(6-Cyclohexyl-4-(dimethylamino)quinazolin-2-yl)-...)
Show SMILES CN(C)c1nc(nc2ccc(cc12)C1CCCCC1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C20H23N5O2/c1-24(2)18-16-10-14(13-6-4-3-5-7-13)8-9-17(16)22-20(23-18)25-12-15(11-21-25)19(26)27/h8-13H,3-7H2,1-2H3,(H,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373674
PNG
(1-(4-(Diethylamino)-7-chloro-6-isopropylquinazolin...)
Show SMILES CCN(CC)c1nc(nc2cc(Cl)c(cc12)C(C)C)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C19H22ClN5O2/c1-5-24(6-2)17-14-7-13(11(3)4)15(20)8-16(14)22-19(23-17)25-10-12(9-21-25)18(26)27/h7-11H,5-6H2,1-4H3,(H,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373546
PNG
(1-[6-(2,6-Dimethyl-phenoxy)-7-fluoro-4-propylamino...)
Show SMILES CCCNc1nc(nc2cc(F)c(Oc3c(C)cccc3C)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C23H22FN5O3/c1-4-8-25-21-16-9-19(32-20-13(2)6-5-7-14(20)3)17(24)10-18(16)27-23(28-21)29-12-15(11-26-29)22(30)31/h5-7,9-12H,4,8H2,1-3H3,(H,30,31)(H,25,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373539
PNG
(1-[4-Amino-6-(2,6-dimethyl-phenoxy)-7-fluoro-quina...)
Show SMILES Cc1cccc(C)c1Oc1cc2c(N)nc(nc2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C20H16FN5O3/c1-10-4-3-5-11(2)17(10)29-16-6-13-15(7-14(16)21)24-20(25-18(13)22)26-9-12(8-23-26)19(27)28/h3-9H,1-2H3,(H,27,28)(H2,22,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373681
PNG
(1-(6-(Cyclohexyloxy)-4-(pyrrolidin-1-yl)quinazolin...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCC2)c2cc(OC3CCCCC3)ccc2n1
Show InChI InChI=1S/C22H25N5O3/c28-21(29)15-13-23-27(14-15)22-24-19-9-8-17(30-16-6-2-1-3-7-16)12-18(19)20(25-22)26-10-4-5-11-26/h8-9,12-14,16H,1-7,10-11H2,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373680
PNG
(1-(6-(Cyclohexyloxy)-4-(diethylamino)quinazolin-2-...)
Show SMILES CCN(CC)c1nc(nc2ccc(OC3CCCCC3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H27N5O3/c1-3-26(4-2)20-18-12-17(30-16-8-6-5-7-9-16)10-11-19(18)24-22(25-20)27-14-15(13-23-27)21(28)29/h10-14,16H,3-9H2,1-2H3,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373642
PNG
(1-(4-(Azepan-1-yl)-7-phenoxyquinazolin-2-yl)-1H-py...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCCCC2)c2ccc(Oc3ccccc3)cc2n1
Show InChI InChI=1S/C24H23N5O3/c30-23(31)17-15-25-29(16-17)24-26-21-14-19(32-18-8-4-3-5-9-18)10-11-20(21)22(27-24)28-12-6-1-2-7-13-28/h3-5,8-11,14-16H,1-2,6-7,12-13H2,(H,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373649
PNG
(1-(4-(Ethyl(methyl)amino)-7-phenoxyquinazolin-2-yl...)
Show SMILES CCN(C)c1nc(nc2cc(Oc3ccccc3)ccc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C21H19N5O3/c1-3-25(2)19-17-10-9-16(29-15-7-5-4-6-8-15)11-18(17)23-21(24-19)26-13-14(12-22-26)20(27)28/h4-13H,3H2,1-2H3,(H,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373553
PNG
(1-((4-Cyclopropanemethylamino)-6-(2,6-dimethylphen...)
Show SMILES Cc1cccc(C)c1Oc1cc2c(NCC3CC3)nc(nc2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C24H22FN5O3/c1-13-4-3-5-14(2)21(13)33-20-8-17-19(9-18(20)25)28-24(29-22(17)26-10-15-6-7-15)30-12-16(11-27-30)23(31)32/h3-5,8-9,11-12,15H,6-7,10H2,1-2H3,(H,31,32)(H,26,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373670
PNG
(1-(6-(Cyclohexyloxy)-4-(ethyl(methyl)amino)-7-chlo...)
Show SMILES CCN(C)c1nc(nc2cc(Cl)c(OC3CCCCC3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C21H24ClN5O3/c1-3-26(2)19-15-9-18(30-14-7-5-4-6-8-14)16(22)10-17(15)24-21(25-19)27-12-13(11-23-27)20(28)29/h9-12,14H,3-8H2,1-2H3,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373541
PNG
(1-[4-Dimethylamino-6-(2,6-dimethyl-phenoxy)-7-fluo...)
Show SMILES CN(C)c1nc(nc2cc(F)c(Oc3c(C)cccc3C)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H20FN5O3/c1-12-6-5-7-13(2)19(12)31-18-8-15-17(9-16(18)23)25-22(26-20(15)27(3)4)28-11-14(10-24-28)21(29)30/h5-11H,1-4H3,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373591
PNG
(1-(4-(Azepan-1-yl)-6-phenylquinazolin-2-yl)-1H-pyr...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCCCC2)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C24H23N5O2/c30-23(31)19-15-25-29(16-19)24-26-21-11-10-18(17-8-4-3-5-9-17)14-20(21)22(27-24)28-12-6-1-2-7-13-28/h3-5,8-11,14-16H,1-2,6-7,12-13H2,(H,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373584
PNG
(1-(4-(Dimethylamino)-6-phenylquinazolin-2-yl)-1H-p...)
Show SMILES CN(C)c1nc(nc2ccc(cc12)-c1ccccc1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C20H17N5O2/c1-24(2)18-16-10-14(13-6-4-3-5-7-13)8-9-17(16)22-20(23-18)25-12-15(11-21-25)19(26)27/h3-12H,1-2H3,(H,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373588
PNG
(1-(6-Phenyl-4-(piperidin-1-yl)quinazolin-2-yl)-1H-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCCC2)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C23H21N5O2/c29-22(30)18-14-24-28(15-18)23-25-20-10-9-17(16-7-3-1-4-8-16)13-19(20)21(26-23)27-11-5-2-6-12-27/h1,3-4,7-10,13-15H,2,5-6,11-12H2,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373665
PNG
(1-(6-(Cyclohexyloxy)-4-(cyclopropylamino)-7-fluoro...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC2CC2)c2cc(OC3CCCCC3)c(F)cc2n1
Show InChI InChI=1S/C21H22FN5O3/c22-16-9-17-15(8-18(16)30-14-4-2-1-3-5-14)19(24-13-6-7-13)26-21(25-17)27-11-12(10-23-27)20(28)29/h8-11,13-14H,1-7H2,(H,28,29)(H,24,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373621
PNG
(1-(6-Phenoxy-4-(pyrrolidin-1-yl)quinazolin-2-yl)-1...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCC2)c2cc(Oc3ccccc3)ccc2n1
Show InChI InChI=1S/C22H19N5O3/c28-21(29)15-13-23-27(14-15)22-24-19-9-8-17(30-16-6-2-1-3-7-16)12-18(19)20(25-22)26-10-4-5-11-26/h1-3,6-9,12-14H,4-5,10-11H2,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373545
PNG
(1-[4-(2-Chloro-phenylamino)-6-(2,6-dimethyl-phenox...)
Show SMILES Cc1cccc(C)c1Oc1cc2c(Nc3ccccc3Cl)nc(nc2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C26H19ClFN5O3/c1-14-6-5-7-15(2)23(14)36-22-10-17-21(11-19(22)28)31-26(33-13-16(12-29-33)25(34)35)32-24(17)30-20-9-4-3-8-18(20)27/h3-13H,1-2H3,(H,34,35)(H,30,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373540
PNG
(1-[6-(2,6-Dimethyl-phenoxy)-7-fluoro-4-methylamino...)
Show SMILES CNc1nc(nc2cc(F)c(Oc3c(C)cccc3C)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C21H18FN5O3/c1-11-5-4-6-12(2)18(11)30-17-7-14-16(8-15(17)22)25-21(26-19(14)23-3)27-10-13(9-24-27)20(28)29/h4-10H,1-3H3,(H,28,29)(H,23,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373648
PNG
(1-(4-(Dipropylamino)-7-phenoxyquinazolin-2-yl)-1H-...)
Show SMILES CCCN(CCC)c1nc(nc2cc(Oc3ccccc3)ccc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C24H25N5O3/c1-3-12-28(13-4-2)22-20-11-10-19(32-18-8-6-5-7-9-18)14-21(20)26-24(27-22)29-16-17(15-25-29)23(30)31/h5-11,14-16H,3-4,12-13H2,1-2H3,(H,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373578
PNG
(1-(4-Cyanamido-6-cyclohexylquinazolin-2-yl)-1H-pyr...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC#N)c2cc(ccc2n1)C1CCCCC1
Show InChI InChI=1S/C19H18N6O2/c20-11-21-17-15-8-13(12-4-2-1-3-5-12)6-7-16(15)23-19(24-17)25-10-14(9-22-25)18(26)27/h6-10,12H,1-5H2,(H,26,27)(H,21,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373691
PNG
(1-(6-Benzyl-4-(ethyl(methyl)amino)quinazolin-2-yl)...)
Show SMILES CCN(C)c1nc(nc2ccc(Cc3ccccc3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H21N5O2/c1-3-26(2)20-18-12-16(11-15-7-5-4-6-8-15)9-10-19(18)24-22(25-20)27-14-17(13-23-27)21(28)29/h4-10,12-14H,3,11H2,1-2H3,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373554
PNG
(1-(6-(2,6-Dimethylphenoxy)-7-fluoro-4-((tetrahydro...)
Show SMILES Cc1cccc(C)c1Oc1cc2c(NC3CCOCC3)nc(nc2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C25H24FN5O4/c1-14-4-3-5-15(2)22(14)35-21-10-18-20(11-19(21)26)29-25(31-13-16(12-27-31)24(32)33)30-23(18)28-17-6-8-34-9-7-17/h3-5,10-13,17H,6-9H2,1-2H3,(H,32,33)(H,28,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373688
PNG
(1-(6-Benzyl-4-(diethylamino)quinazolin-2-yl)-1H-py...)
Show SMILES CCN(CC)c1nc(nc2ccc(Cc3ccccc3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C23H23N5O2/c1-3-27(4-2)21-19-13-17(12-16-8-6-5-7-9-16)10-11-20(19)25-23(26-21)28-15-18(14-24-28)22(29)30/h5-11,13-15H,3-4,12H2,1-2H3,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373580
PNG
(1-(4-(Azepan-1-yl)-6-cyclohexylquinazolin-2-yl)-1H...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCCCC2)c2cc(ccc2n1)C1CCCCC1
Show InChI InChI=1S/C24H29N5O2/c30-23(31)19-15-25-29(16-19)24-26-21-11-10-18(17-8-4-3-5-9-17)14-20(21)22(27-24)28-12-6-1-2-7-13-28/h10-11,14-17H,1-9,12-13H2,(H,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373552
PNG
(1-((4-Cyclopropylamino)-6-(2,6-dimethylphenoxy)-7-...)
Show SMILES Cc1cccc(C)c1Oc1cc2c(NC3CC3)nc(nc2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C23H20FN5O3/c1-12-4-3-5-13(2)20(12)32-19-8-16-18(9-17(19)24)27-23(28-21(16)26-15-6-7-15)29-11-14(10-25-29)22(30)31/h3-5,8-11,15H,6-7H2,1-2H3,(H,30,31)(H,26,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373689
PNG
(1-(6-Benzyl-4-(pyrrolidin-1-yl)quinazolin-2-yl)-1H...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCC2)c2cc(Cc3ccccc3)ccc2n1
Show InChI InChI=1S/C23H21N5O2/c29-22(30)18-14-24-28(15-18)23-25-20-9-8-17(12-16-6-2-1-3-7-16)13-19(20)21(26-23)27-10-4-5-11-27/h1-3,6-9,13-15H,4-5,10-12H2,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373687
PNG
(1-(6-Benzyl-4-(dimethylamino)quinazolin-2-yl)-1H-p...)
Show SMILES CN(C)c1nc(nc2ccc(Cc3ccccc3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C21H19N5O2/c1-25(2)19-17-11-15(10-14-6-4-3-5-7-14)8-9-18(17)23-21(24-19)26-13-16(12-22-26)20(27)28/h3-9,11-13H,10H2,1-2H3,(H,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373690
PNG
(1-(6-Benzyl-4-(cyclopropylamino)quinazolin-2-yl)-1...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC2CC2)c2cc(Cc3ccccc3)ccc2n1
Show InChI InChI=1S/C22H19N5O2/c28-21(29)16-12-23-27(13-16)22-25-19-9-6-15(10-14-4-2-1-3-5-14)11-18(19)20(26-22)24-17-7-8-17/h1-6,9,11-13,17H,7-8,10H2,(H,28,29)(H,24,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373669
PNG
(1-(6-(Cyclohexyloxy)-7-chloro-4-(pyrrolidin-1-yl)q...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCC2)c2cc(OC3CCCCC3)c(Cl)cc2n1
Show InChI InChI=1S/C22H24ClN5O3/c23-17-11-18-16(10-19(17)31-15-6-2-1-3-7-15)20(27-8-4-5-9-27)26-22(25-18)28-13-14(12-24-28)21(29)30/h10-13,15H,1-9H2,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373587
PNG
(1-(6-Phenyl-4-(phenylamino)quinazolin-2-yl)-1H-pyr...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(Nc2ccccc2)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C24H17N5O2/c30-23(31)18-14-25-29(15-18)24-27-21-12-11-17(16-7-3-1-4-8-16)13-20(21)22(28-24)26-19-9-5-2-6-10-19/h1-15H,(H,30,31)(H,26,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373572
PNG
(1-(6-Cyclohexyl-4-(4-fluoropiperidin-1-yl)quinazol...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCC(F)CC2)c2cc(ccc2n1)C1CCCCC1
Show InChI InChI=1S/C23H26FN5O2/c24-18-8-10-28(11-9-18)21-19-12-16(15-4-2-1-3-5-15)6-7-20(19)26-23(27-21)29-14-17(13-25-29)22(30)31/h6-7,12-15,18H,1-5,8-11H2,(H,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373547
PNG
((rac)-1-[6-(2,6-Dimethyl-phenoxy)-7-fluoro-4-(2-me...)
Show SMILES COCC(C)Nc1nc(nc2cc(F)c(Oc3c(C)cccc3C)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1/C24H24FN5O4/c1-13-6-5-7-14(2)21(13)34-20-8-17-19(9-18(20)25)28-24(29-22(17)27-15(3)12-33-4)30-11-16(10-26-30)23(31)32/h5-11,15H,12H2,1-4H3,(H,31,32)(H,27,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373647
PNG
(1-(4-(Dibutylamino)-7-phenoxyquinazolin-2-yl)-1H-p...)
Show SMILES CCCCN(CCCC)c1nc(nc2cc(Oc3ccccc3)ccc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C26H29N5O3/c1-3-5-14-30(15-6-4-2)24-22-13-12-21(34-20-10-8-7-9-11-20)16-23(22)28-26(29-24)31-18-19(17-27-31)25(32)33/h7-13,16-18H,3-6,14-15H2,1-2H3,(H,32,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373617
PNG
(1-(4-(4-Acetamidopiperidin-1-yl)-6-(4-chlorophenox...)
Show SMILES CC(=O)NC1CCN(CC1)c1nc(nc2ccc(Oc3ccc(Cl)cc3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C25H23ClN6O4/c1-15(33)28-18-8-10-31(11-9-18)23-21-12-20(36-19-4-2-17(26)3-5-19)6-7-22(21)29-25(30-23)32-14-16(13-27-32)24(34)35/h2-7,12-14,18H,8-11H2,1H3,(H,28,33)(H,34,35)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373593
PNG
(1-(4-Cyanamido-6-phenylquinazolin-2-yl)-1H-pyrazol...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC#N)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C19H12N6O2/c20-11-21-17-15-8-13(12-4-2-1-3-5-12)6-7-16(15)23-19(24-17)25-10-14(9-22-25)18(26)27/h1-10H,(H,26,27)(H,21,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373570
PNG
(1-(4-((2-Chlorophenyl)amino)-6-cyclohexylquinazoli...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(Nc2ccccc2Cl)c2cc(ccc2n1)C1CCCCC1
Show InChI InChI=1S/C24H22ClN5O2/c25-19-8-4-5-9-21(19)27-22-18-12-16(15-6-2-1-3-7-15)10-11-20(18)28-24(29-22)30-14-17(13-26-30)23(31)32/h4-5,8-15H,1-3,6-7H2,(H,31,32)(H,27,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373565
PNG
(1-(6-Cyclohexyl-4-(piperidin-1-yl)quinazolin-2-yl)...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCCC2)c2cc(ccc2n1)C1CCCCC1
Show InChI InChI=1S/C23H27N5O2/c29-22(30)18-14-24-28(15-18)23-25-20-10-9-17(16-7-3-1-4-8-16)13-19(20)21(26-23)27-11-5-2-6-12-27/h9-10,13-16H,1-8,11-12H2,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373660
PNG
(1-(6-(Cyclohexyloxy)-4-(dimethylamino)-7-fluoroqui...)
Show SMILES CN(C)c1nc(nc2cc(F)c(OC3CCCCC3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C20H22FN5O3/c1-25(2)18-14-8-17(29-13-6-4-3-5-7-13)15(21)9-16(14)23-20(24-18)26-11-12(10-22-26)19(27)28/h8-11,13H,3-7H2,1-2H3,(H,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373561
PNG
(1-(6-Cyclohexyl-4-methylamino-quinazolin-2-yl)-1H-...)
Show SMILES CNc1nc(nc2ccc(cc12)C1CCCCC1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C19H21N5O2/c1-20-17-15-9-13(12-5-3-2-4-6-12)7-8-16(15)22-19(23-17)24-11-14(10-21-24)18(25)26/h7-12H,2-6H2,1H3,(H,25,26)(H,20,22,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373549
PNG
(1-[6-(2,6-Dimethyl-phenoxy)-4-dibutylamino-7-fluor...)
Show SMILES CCCCN(CCCC)c1nc(nc2cc(F)c(Oc3c(C)cccc3C)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C28H32FN5O3/c1-5-7-12-33(13-8-6-2)26-21-14-24(37-25-18(3)10-9-11-19(25)4)22(29)15-23(21)31-28(32-26)34-17-20(16-30-34)27(35)36/h9-11,14-17H,5-8,12-13H2,1-4H3,(H,35,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373664
PNG
(1-(6-(Cyclohexyloxy)-4-(ethyl(methyl)amino)-7-fluo...)
Show SMILES CCN(C)c1nc(nc2cc(F)c(OC3CCCCC3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C21H24FN5O3/c1-3-26(2)19-15-9-18(30-14-7-5-4-6-8-14)16(22)10-17(15)24-21(25-19)27-12-13(11-23-27)20(28)29/h9-12,14H,3-8H2,1-2H3,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373559
PNG
(1-(6-(2,6-Dimethylphenoxy)-7-fluoro-4-morpholinoqu...)
Show SMILES Cc1cccc(C)c1Oc1cc2c(nc(nc2cc1F)-n1cc(cn1)C(O)=O)N1CCOCC1
Show InChI InChI=1S/C24H22FN5O4/c1-14-4-3-5-15(2)21(14)34-20-10-17-19(11-18(20)25)27-24(30-13-16(12-26-30)23(31)32)28-22(17)29-6-8-33-9-7-29/h3-5,10-13H,6-9H2,1-2H3,(H,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373607
PNG
(1-(6-(4-Chlorophenoxy)-4-(cyclopropylamino)quinazo...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC2CC2)c2cc(Oc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C21H16ClN5O3/c22-13-1-5-15(6-2-13)30-16-7-8-18-17(9-16)19(24-14-3-4-14)26-21(25-18)27-11-12(10-23-27)20(28)29/h1-2,5-11,14H,3-4H2,(H,28,29)(H,24,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373557
PNG
(1-(6-(2,6-Dimethylphenoxy)-7-fluoro-4-thiomorpholi...)
Show SMILES Cc1cccc(C)c1Oc1cc2c(nc(nc2cc1F)-n1cc(cn1)C(O)=O)N1CCSCC1
Show InChI InChI=1S/C24H22FN5O3S/c1-14-4-3-5-15(2)21(14)33-20-10-17-19(11-18(20)25)27-24(30-13-16(12-26-30)23(31)32)28-22(17)29-6-8-34-9-7-29/h3-5,10-13H,6-9H2,1-2H3,(H,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373633
PNG
(1-(7-Phenoxy-4-(piperidin-1-yl)quinazolin-2-yl)-1H...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCCC2)c2ccc(Oc3ccccc3)cc2n1
Show InChI InChI=1S/C23H21N5O3/c29-22(30)16-14-24-28(15-16)23-25-20-13-18(31-17-7-3-1-4-8-17)9-10-19(20)21(26-23)27-11-5-2-6-12-27/h1,3-4,7-10,13-15H,2,5-6,11-12H2,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373694
PNG
(1-(6-Isopropyl-4-(diethylamino)quinazolin-2-yl)-1H...)
Show SMILES CCN(CC)c1nc(nc2ccc(cc12)C(C)C)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C19H23N5O2/c1-5-23(6-2)17-15-9-13(12(3)4)7-8-16(15)21-19(22-17)24-11-14(10-20-24)18(25)26/h7-12H,5-6H2,1-4H3,(H,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373652
PNG
(1-(4-(Cyclohexylamino)-7-phenoxyquinazolin-2-yl)-1...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC2CCCCC2)c2ccc(Oc3ccccc3)cc2n1
Show InChI InChI=1S/C24H23N5O3/c30-23(31)16-14-25-29(15-16)24-27-21-13-19(32-18-9-5-2-6-10-18)11-12-20(21)22(28-24)26-17-7-3-1-4-8-17/h2,5-6,9-15,17H,1,3-4,7-8H2,(H,30,31)(H,26,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373693
PNG
(1-(6-Isopropyl-4-(dimethylamino)quinazolin-2-yl)-1...)
Show SMILES CC(C)c1ccc2nc(nc(N(C)C)c2c1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C17H19N5O2/c1-10(2)11-5-6-14-13(7-11)15(21(3)4)20-17(19-14)22-9-12(8-18-22)16(23)24/h5-10H,1-4H3,(H,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373677
PNG
(1-(4-(Cyclopropylamino)-7-chloro-6-isopropylquinaz...)
Show SMILES CC(C)c1cc2c(NC3CC3)nc(nc2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C18H18ClN5O2/c1-9(2)12-5-13-15(6-14(12)19)22-18(23-16(13)21-11-3-4-11)24-8-10(7-20-24)17(25)26/h5-9,11H,3-4H2,1-2H3,(H,25,26)(H,21,22,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373671
PNG
(1-(6-(Cyclohexyloxy)-4-(cyclopropylamino)-7-chloro...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC2CC2)c2cc(OC3CCCCC3)c(Cl)cc2n1
Show InChI InChI=1S/C21H22ClN5O3/c22-16-9-17-15(8-18(16)30-14-4-2-1-3-5-14)19(24-13-6-7-13)26-21(25-17)27-11-12(10-23-27)20(28)29/h8-11,13-14H,1-7H2,(H,28,29)(H,24,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373598
PNG
(1-(4-Amino-6-phenylquinazolin-2-yl)-1H-pyrazole-4-...)
Show SMILES Nc1nc(nc2ccc(cc12)-c1ccccc1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C18H13N5O2/c19-16-14-8-12(11-4-2-1-3-5-11)6-7-15(14)21-18(22-16)23-10-13(9-20-23)17(24)25/h1-10H,(H,24,25)(H2,19,21,22)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373643
PNG
(1-(4-(Diethylamino)-6-(piperidin-1-yl)quinazolin-2...)
Show SMILES CCN(CC)c1nc(nc2ccc(cc12)N1CCCCC1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C21H26N6O2/c1-3-25(4-2)19-17-12-16(26-10-6-5-7-11-26)8-9-18(17)23-21(24-19)27-14-15(13-22-27)20(28)29/h8-9,12-14H,3-7,10-11H2,1-2H3,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373560
PNG
(1-(4-(4-Acetamidopiperidin-1-yl)-6-(2,6-dimethylph...)
Show SMILES CC(=O)NC1CCN(CC1)c1nc(nc2cc(F)c(Oc3c(C)cccc3C)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C27H27FN6O4/c1-15-5-4-6-16(2)24(15)38-23-11-20-22(12-21(23)28)31-27(34-14-18(13-29-34)26(36)37)32-25(20)33-9-7-19(8-10-33)30-17(3)35/h4-6,11-14,19H,7-10H2,1-3H3,(H,30,35)(H,36,37)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 126n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373651
PNG
(1-(7-Bromo-4-(diethylamino)quinazolin-2-yl)-1H-pyr...)
Show SMILES CCN(CC)c1nc(nc2cc(Br)ccc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C16H16BrN5O2/c1-3-21(4-2)14-12-6-5-11(17)7-13(12)19-16(20-14)22-9-10(8-18-22)15(23)24/h5-9H,3-4H2,1-2H3,(H,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 126n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373551
PNG
(1-(4-((Cyclohexylmethyl)amino)-6-(2,6-dimethylphen...)
Show SMILES Cc1cccc(C)c1Oc1cc2c(NCC3CCCCC3)nc(nc2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C27H28FN5O3/c1-16-7-6-8-17(2)24(16)36-23-11-20-22(12-21(23)28)31-27(33-15-19(14-30-33)26(34)35)32-25(20)29-13-18-9-4-3-5-10-18/h6-8,11-12,14-15,18H,3-5,9-10,13H2,1-2H3,(H,34,35)(H,29,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 126n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373592
PNG
(1-(4-((Cyclohexylmethyl)amino)-6-phenylquinazolin-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NCC2CCCCC2)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C25H25N5O2/c31-24(32)20-15-27-30(16-20)25-28-22-12-11-19(18-9-5-2-6-10-18)13-21(22)23(29-25)26-14-17-7-3-1-4-8-17/h2,5-6,9-13,15-17H,1,3-4,7-8,14H2,(H,31,32)(H,26,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 126n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373558
PNG
(1-(6-(2,6-dimethylphenoxy)-7-fluoro-4-(4-hydroxypi...)
Show SMILES Cc1cccc(C)c1Oc1cc2c(nc(nc2cc1F)-n1cc(cn1)C(O)=O)N1CCC(O)CC1
Show InChI InChI=1S/C25H24FN5O4/c1-14-4-3-5-15(2)22(14)35-21-10-18-20(11-19(21)26)28-25(31-13-16(12-27-31)24(33)34)29-23(18)30-8-6-17(32)7-9-30/h3-5,10-13,17,32H,6-9H2,1-2H3,(H,33,34)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 126n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373614
PNG
(1-(6-(4-Chlorophenoxy)-4-((tetrahydro-2H-pyran-4-y...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC2CCOCC2)c2cc(Oc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C23H20ClN5O4/c24-15-1-3-17(4-2-15)33-18-5-6-20-19(11-18)21(26-16-7-9-32-10-8-16)28-23(27-20)29-13-14(12-25-29)22(30)31/h1-6,11-13,16H,7-10H2,(H,30,31)(H,26,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 126n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373542
PNG
(1-[6-(2,6-Dimethyl-phenoxy)-7-fluoro-4-piperidin-1...)
Show SMILES Cc1cccc(C)c1Oc1cc2c(nc(nc2cc1F)-n1cc(cn1)C(O)=O)N1CCCCC1
Show InChI InChI=1S/C25H24FN5O3/c1-15-7-6-8-16(2)22(15)34-21-11-18-20(12-19(21)26)28-25(31-14-17(13-27-31)24(32)33)29-23(18)30-9-4-3-5-10-30/h6-8,11-14H,3-5,9-10H2,1-2H3,(H,32,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 126n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373582
PNG
(1-(6-Cyclohexyl-4-((cyclohexylmethyl)amino)quinazo...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NCC2CCCCC2)c2cc(ccc2n1)C1CCCCC1
Show InChI InChI=1S/C25H31N5O2/c31-24(32)20-15-27-30(16-20)25-28-22-12-11-19(18-9-5-2-6-10-18)13-21(22)23(29-25)26-14-17-7-3-1-4-8-17/h11-13,15-18H,1-10,14H2,(H,31,32)(H,26,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 126n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373571
PNG
(1-(4-(4-Cyanopiperidin-1-yl)-6-cyclohexylquinazoli...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCC(CC2)C#N)c2cc(ccc2n1)C1CCCCC1
Show InChI InChI=1S/C24H26N6O2/c25-13-16-8-10-29(11-9-16)22-20-12-18(17-4-2-1-3-5-17)6-7-21(20)27-24(28-22)30-15-19(14-26-30)23(31)32/h6-7,12,14-17H,1-5,8-11H2,(H,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 126n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373577
PNG
(1-(6-Cyclohexyl-4-thiomorpholinoquinazolin-2-yl)-1...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCSCC2)c2cc(ccc2n1)C1CCCCC1
Show InChI InChI=1S/C22H25N5O2S/c28-21(29)17-13-23-27(14-17)22-24-19-7-6-16(15-4-2-1-3-5-15)12-18(19)20(25-22)26-8-10-30-11-9-26/h6-7,12-15H,1-5,8-11H2,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 126n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373623
PNG
(1-(4-(Cyclopropylamino)-6-phenoxyquinazolin-2-yl)-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC2CC2)c2cc(Oc3ccccc3)ccc2n1
Show InChI InChI=1S/C21H17N5O3/c27-20(28)13-11-22-26(12-13)21-24-18-9-8-16(29-15-4-2-1-3-5-15)10-17(18)19(25-21)23-14-6-7-14/h1-5,8-12,14H,6-7H2,(H,27,28)(H,23,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 158n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373599
PNG
(1-(6-Phenyl-4-thiomorpholinoquinazolin-2-yl)-1H-py...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCSCC2)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C22H19N5O2S/c28-21(29)17-13-23-27(14-17)22-24-19-7-6-16(15-4-2-1-3-5-15)12-18(19)20(25-22)26-8-10-30-11-9-26/h1-7,12-14H,8-11H2,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 158n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373576
PNG
(1-(6-Cyclohexyl-4-morpholinoquinazolin-2-yl)-1H-py...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCOCC2)c2cc(ccc2n1)C1CCCCC1
Show InChI InChI=1S/C22H25N5O3/c28-21(29)17-13-23-27(14-17)22-24-19-7-6-16(15-4-2-1-3-5-15)12-18(19)20(25-22)26-8-10-30-11-9-26/h6-7,12-15H,1-5,8-11H2,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 158n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373672
PNG
(1-(7-Chloro-6-isopropyl-4-morpholinoquinazolin-2-y...)
Show SMILES CC(C)c1cc2c(nc(nc2cc1Cl)-n1cc(cn1)C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20ClN5O3/c1-11(2)13-7-14-16(8-15(13)20)22-19(25-10-12(9-21-25)18(26)27)23-17(14)24-3-5-28-6-4-24/h7-11H,3-6H2,1-2H3,(H,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 158n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373695
PNG
(1-(6-Isopropyl-4-(pyrrolidin-1-yl)quinazolin-2-yl)...)
Show SMILES CC(C)c1ccc2nc(nc(N3CCCC3)c2c1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C19H21N5O2/c1-12(2)13-5-6-16-15(9-13)17(23-7-3-4-8-23)22-19(21-16)24-11-14(10-20-24)18(25)26/h5-6,9-12H,3-4,7-8H2,1-2H3,(H,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 158n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373683
PNG
(1-(6-(Cyclohexyloxy)-4-(cyclopropylamino)quinazoli...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC2CC2)c2cc(OC3CCCCC3)ccc2n1
Show InChI InChI=1S/C21H23N5O3/c27-20(28)13-11-22-26(12-13)21-24-18-9-8-16(29-15-4-2-1-3-5-15)10-17(18)19(25-21)23-14-6-7-14/h8-12,14-15H,1-7H2,(H,27,28)(H,23,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 158n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373579
PNG
(1-(4-(tert-Butylamino)-6-cyclohexylquinazolin-2-yl...)
Show SMILES CC(C)(C)Nc1nc(nc2ccc(cc12)C1CCCCC1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H27N5O2/c1-22(2,3)26-19-17-11-15(14-7-5-4-6-8-14)9-10-18(17)24-21(25-19)27-13-16(12-23-27)20(28)29/h9-14H,4-8H2,1-3H3,(H,28,29)(H,24,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 158n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373638
PNG
(1-(4-((Cyclohexylmethyl)amino)-7-phenoxyquinazolin...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NCC2CCCCC2)c2ccc(Oc3ccccc3)cc2n1
Show InChI InChI=1S/C25H25N5O3/c31-24(32)18-15-27-30(16-18)25-28-22-13-20(33-19-9-5-2-6-10-19)11-12-21(22)23(29-25)26-14-17-7-3-1-4-8-17/h2,5-6,9-13,15-17H,1,3-4,7-8,14H2,(H,31,32)(H,26,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 158n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373639
PNG
(1-(4-(4-Isopropylpiperidin-1-yl)-7-phenoxyquinazol...)
Show SMILES CC(C)C1CCN(CC1)c1nc(nc2cc(Oc3ccccc3)ccc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C26H27N5O3/c1-17(2)18-10-12-30(13-11-18)24-22-9-8-21(34-20-6-4-3-5-7-20)14-23(22)28-26(29-24)31-16-19(15-27-31)25(32)33/h3-9,14-18H,10-13H2,1-2H3,(H,32,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 158n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373650
PNG
(1-(4-((2-Methoxyethyl)(methyl)amino)-7-phenoxyquin...)
Show SMILES COCCN(C)c1nc(nc2cc(Oc3ccccc3)ccc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H21N5O4/c1-26(10-11-30-2)20-18-9-8-17(31-16-6-4-3-5-7-16)12-19(18)24-22(25-20)27-14-15(13-23-27)21(28)29/h3-9,12-14H,10-11H2,1-2H3,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 158n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373697
PNG
(1-(6-Isopropyl-4-(ethyl(methyl)amino)quinazolin-2-...)
Show SMILES CCN(C)c1nc(nc2ccc(cc12)C(C)C)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C18H21N5O2/c1-5-22(4)16-14-8-12(11(2)3)6-7-15(14)20-18(21-16)23-10-13(9-19-23)17(24)25/h6-11H,5H2,1-4H3,(H,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 158n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373620
PNG
(1-(4-(tert-Butylamino)-6-phenoxyquinazolin-2-yl)-1...)
Show SMILES CC(C)(C)Nc1nc(nc2ccc(Oc3ccccc3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H21N5O3/c1-22(2,3)26-19-17-11-16(30-15-7-5-4-6-8-15)9-10-18(17)24-21(25-19)27-13-14(12-23-27)20(28)29/h4-13H,1-3H3,(H,28,29)(H,24,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373655
PNG
(1-(4-((Cyclopropylmethyl)amino)-7-phenoxyquinazoli...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NCC2CC2)c2ccc(Oc3ccccc3)cc2n1
Show InChI InChI=1S/C22H19N5O3/c28-21(29)15-12-24-27(13-15)22-25-19-10-17(30-16-4-2-1-3-5-16)8-9-18(19)20(26-22)23-11-14-6-7-14/h1-5,8-10,12-14H,6-7,11H2,(H,28,29)(H,23,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373666
PNG
(1-(6-(Cyclohexyloxy)-7-chloro-4-morpholinoquinazol...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCOCC2)c2cc(OC3CCCCC3)c(Cl)cc2n1
Show InChI InChI=1S/C22H24ClN5O4/c23-17-11-18-16(10-19(17)32-15-4-2-1-3-5-15)20(27-6-8-31-9-7-27)26-22(25-18)28-13-14(12-24-28)21(29)30/h10-13,15H,1-9H2,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373555
PNG
(1-(6-(2,6-Dimethylphenoxy)-7-fluoro-4-(4-methyl-1,...)
Show SMILES CN1CCCN(CC1)c1nc(nc2cc(F)c(Oc3c(C)cccc3C)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C26H27FN6O3/c1-16-6-4-7-17(2)23(16)36-22-12-19-21(13-20(22)27)29-26(33-15-18(14-28-33)25(34)35)30-24(19)32-9-5-8-31(3)10-11-32/h4,6-7,12-15H,5,8-11H2,1-3H3,(H,34,35)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373574
PNG
(1-(6-Cyclohexyl-4-(cyclopropylamino)quinazolin-2-y...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC2CC2)c2cc(ccc2n1)C1CCCCC1
Show InChI InChI=1S/C21H23N5O2/c27-20(28)15-11-22-26(12-15)21-24-18-9-6-14(13-4-2-1-3-5-13)10-17(18)19(25-21)23-16-7-8-16/h6,9-13,16H,1-5,7-8H2,(H,27,28)(H,23,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373619
PNG
(1-(6-(4-Chlorophenoxy)-4-(4-methyl-1,4-diazepan-1-...)
Show SMILES CN1CCCN(CC1)c1nc(nc2ccc(Oc3ccc(Cl)cc3)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C24H23ClN6O3/c1-29-9-2-10-30(12-11-29)22-20-13-19(34-18-5-3-17(25)4-6-18)7-8-21(20)27-24(28-22)31-15-16(14-26-31)23(32)33/h3-8,13-15H,2,9-12H2,1H3,(H,32,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373600
PNG
(1-(4-(4-Acetamidopiperidin-1-yl)-6-phenylquinazoli...)
Show SMILES CC(=O)NC1CCN(CC1)c1nc(nc2ccc(cc12)-c1ccccc1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C25H24N6O3/c1-16(32)27-20-9-11-30(12-10-20)23-21-13-18(17-5-3-2-4-6-17)7-8-22(21)28-25(29-23)31-15-19(14-26-31)24(33)34/h2-8,13-15,20H,9-12H2,1H3,(H,27,32)(H,33,34)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373590
PNG
(1-(4-((2-Chlorophenyl)amino)-6-phenylquinazolin-2-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(Nc2ccccc2Cl)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C24H16ClN5O2/c25-19-8-4-5-9-21(19)27-22-18-12-16(15-6-2-1-3-7-15)10-11-20(18)28-24(29-22)30-14-17(13-26-30)23(31)32/h1-14H,(H,31,32)(H,27,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373583
PNG
(1-(6-Cyclohexyl-4-(methylsulfonamido)quinazolin-2-...)
Show SMILES CS(=O)(=O)Nc1nc(nc2ccc(cc12)C1CCCCC1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C19H21N5O4S/c1-29(27,28)23-17-15-9-13(12-5-3-2-4-6-12)7-8-16(15)21-19(22-17)24-11-14(10-20-24)18(25)26/h7-12H,2-6H2,1H3,(H,25,26)(H,21,22,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373657
PNG
(1-(6-(Cyclohexyloxy)-7-fluoro-4-morpholinoquinazol...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCOCC2)c2cc(OC3CCCCC3)c(F)cc2n1
Show InChI InChI=1S/C22H24FN5O4/c23-17-11-18-16(10-19(17)32-15-4-2-1-3-5-15)20(27-6-8-31-9-7-27)26-22(25-18)28-13-14(12-24-28)21(29)30/h10-13,15H,1-9H2,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373603
PNG
(1-(4-Morpholino-6-phenylquinazolin-2-yl)-1H-pyrazo...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCOCC2)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C22H19N5O3/c28-21(29)17-13-23-27(14-17)22-24-19-7-6-16(15-4-2-1-3-5-15)12-18(19)20(25-22)26-8-10-30-11-9-26/h1-7,12-14H,8-11H2,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 316n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373595
PNG
(1-(4-(Cyclopropylamino)-6-phenylquinazolin-2-yl)-1...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC2CC2)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C21H17N5O2/c27-20(28)15-11-22-26(12-15)21-24-18-9-6-14(13-4-2-1-3-5-13)10-17(18)19(25-21)23-16-7-8-16/h1-6,9-12,16H,7-8H2,(H,27,28)(H,23,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 316n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373686
PNG
(1-(6-Benzyl-4-morpholinoquinazolin-2-yl)-1H-pyrazo...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCOCC2)c2cc(Cc3ccccc3)ccc2n1
Show InChI InChI=1S/C23H21N5O3/c29-22(30)18-14-24-28(15-18)23-25-20-7-6-17(12-16-4-2-1-3-5-16)13-19(20)21(26-23)27-8-10-31-11-9-27/h1-7,13-15H,8-12H2,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 316n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373596
PNG
(1-(4-(tert-Butylamino)-6-phenylquinazolin-2-yl)-1H...)
Show SMILES CC(C)(C)Nc1nc(nc2ccc(cc12)-c1ccccc1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H21N5O2/c1-22(2,3)26-19-17-11-15(14-7-5-4-6-8-14)9-10-18(17)24-21(25-19)27-13-16(12-23-27)20(28)29/h4-13H,1-3H3,(H,28,29)(H,24,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 316n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373624
PNG
(1-(6-Phenoxy-4-((tetrahydro-2H-pyran-4-yl)amino)qu...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC2CCOCC2)c2cc(Oc3ccccc3)ccc2n1
Show InChI InChI=1S/C23H21N5O4/c29-22(30)15-13-24-28(14-15)23-26-20-7-6-18(32-17-4-2-1-3-5-17)12-19(20)21(27-23)25-16-8-10-31-11-9-16/h1-7,12-14,16H,8-11H2,(H,29,30)(H,25,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 316n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373602
PNG
(1-(4-(4-Methyl-1,4-diazepan-1-yl)-6-phenylquinazol...)
Show SMILES CN1CCCN(CC1)c1nc(nc2ccc(cc12)-c1ccccc1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C24H24N6O2/c1-28-10-5-11-29(13-12-28)22-20-14-18(17-6-3-2-4-7-17)8-9-21(20)26-24(27-22)30-16-19(15-25-30)23(31)32/h2-4,6-9,14-16H,5,10-13H2,1H3,(H,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 398n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373564
PNG
(1-(6-Cyclohexyl-4-(pyrrolidin-1-yl)quinazolin-2-yl...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCC2)c2cc(ccc2n1)C1CCCCC1
Show InChI InChI=1S/C22H25N5O2/c28-21(29)17-13-23-27(14-17)22-24-19-9-8-16(15-6-2-1-3-7-15)12-18(19)20(25-22)26-10-4-5-11-26/h8-9,12-15H,1-7,10-11H2,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 398n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373604
PNG
(1-(4-(4-Cyanopiperidin-1-yl)-6-phenylquinazolin-2-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCC(CC2)C#N)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C24H20N6O2/c25-13-16-8-10-29(11-9-16)22-20-12-18(17-4-2-1-3-5-17)6-7-21(20)27-24(28-22)30-15-19(14-26-30)23(31)32/h1-7,12,14-16H,8-11H2,(H,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 398n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373678
PNG
(1-(6-(Cyclohexyloxy)-4-morpholinoquinazolin-2-yl)-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCOCC2)c2cc(OC3CCCCC3)ccc2n1
Show InChI InChI=1S/C22H25N5O4/c28-21(29)15-13-23-27(14-15)22-24-19-7-6-17(31-16-4-2-1-3-5-16)12-18(19)20(25-22)26-8-10-30-11-9-26/h6-7,12-14,16H,1-5,8-11H2,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 398n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373645
PNG
(1-(7-Phenoxy-4-thiomorpholinoquinazolin-2-yl)-1H-p...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCSCC2)c2ccc(Oc3ccccc3)cc2n1
Show InChI InChI=1S/C22H19N5O3S/c28-21(29)15-13-23-27(14-15)22-24-19-12-17(30-16-4-2-1-3-5-16)6-7-18(19)20(25-22)26-8-10-31-11-9-26/h1-7,12-14H,8-11H2,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 501n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373656
PNG
(1-(4-(tert-Butylamino)-7-phenoxyquinazolin-2-yl)-1...)
Show SMILES CC(C)(C)Nc1nc(nc2cc(Oc3ccccc3)ccc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C22H21N5O3/c1-22(2,3)26-19-17-10-9-16(30-15-7-5-4-6-8-15)11-18(17)24-21(25-19)27-13-14(12-23-27)20(28)29/h4-13H,1-3H3,(H,28,29)(H,24,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 501n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373646
PNG
(1-(4-(4-Fluoropiperidin-1-yl)-7-phenoxyquinazolin-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCC(F)CC2)c2ccc(Oc3ccccc3)cc2n1
Show InChI InChI=1S/C23H20FN5O3/c24-16-8-10-28(11-9-16)21-19-7-6-18(32-17-4-2-1-3-5-17)12-20(19)26-23(27-21)29-14-15(13-25-29)22(30)31/h1-7,12-14,16H,8-11H2,(H,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 501n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373641
PNG
(1-(4-(Cyclopropylamino)-7-phenoxyquinazolin-2-yl)-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC2CC2)c2ccc(Oc3ccccc3)cc2n1
Show InChI InChI=1S/C21H17N5O3/c27-20(28)13-11-22-26(12-13)21-24-18-10-16(29-15-4-2-1-3-5-15)8-9-17(18)19(25-21)23-14-6-7-14/h1-5,8-12,14H,6-7H2,(H,27,28)(H,23,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 501n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373601
PNG
(1-(6-Phenyl-4-((tetrahydro-2H-pyran-4-yl)amino)qui...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(NC2CCOCC2)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C23H21N5O3/c29-22(30)17-13-24-28(14-17)23-26-20-7-6-16(15-4-2-1-3-5-15)12-19(20)21(27-23)25-18-8-10-31-11-9-18/h1-7,12-14,18H,8-11H2,(H,29,30)(H,25,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 631n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373644
PNG
(1-(4-Morpholino-7-phenoxyquinazolin-2-yl)-1H-pyraz...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCOCC2)c2ccc(Oc3ccccc3)cc2n1
Show InChI InChI=1S/C22H19N5O4/c28-21(29)15-13-23-27(14-15)22-24-19-12-17(31-16-4-2-1-3-5-16)6-7-18(19)20(25-22)26-8-10-30-11-9-26/h1-7,12-14H,8-11H2,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 631n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373636
PNG
(1-(7-Phenyl-4-(piperidin-1-yl)quinazolin-2-yl)-1H-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCCC2)c2ccc(cc2n1)-c1ccccc1
Show InChI InChI=1S/C23H21N5O2/c29-22(30)18-14-24-28(15-18)23-25-20-13-17(16-7-3-1-4-8-16)9-10-19(20)21(26-23)27-11-5-2-6-12-27/h1,3-4,7-10,13-15H,2,5-6,11-12H2,(H,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 794n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373696
PNG
(1-(6-Isopropyl-4-(cyclopropylamino)quinazolin-2-yl...)
Show SMILES CC(C)c1ccc2nc(nc(NC3CC3)c2c1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C18H19N5O2/c1-10(2)11-3-6-15-14(7-11)16(20-13-4-5-13)22-18(21-15)23-9-12(8-19-23)17(24)25/h3,6-10,13H,4-5H2,1-2H3,(H,24,25)(H,20,21,22)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373634
PNG
(1-(4-(Dimethylamino)-7-phenylquinazolin-2-yl)-1H-p...)
Show SMILES CN(C)c1nc(nc2cc(ccc12)-c1ccccc1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C20H17N5O2/c1-24(2)18-16-9-8-14(13-6-4-3-5-7-13)10-17(16)22-20(23-18)25-12-15(11-21-25)19(26)27/h3-12H,1-2H3,(H,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373562
PNG
(1-[6-Cyclohexyl-4-(2,6-dimethyl-benzylamino)-quina...)
Show SMILES Cc1cccc(C)c1CNc1nc(nc2ccc(cc12)C1CCCCC1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C27H29N5O2/c1-17-7-6-8-18(2)23(17)15-28-25-22-13-20(19-9-4-3-5-10-19)11-12-24(22)30-27(31-25)32-16-21(14-29-32)26(33)34/h6-8,11-14,16,19H,3-5,9-10,15H2,1-2H3,(H,33,34)(H,28,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.26E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373548
PNG
(1-[4-(2-Diethylamino-ethylamino)-6-(2,6-dimethyl-p...)
Show SMILES CCN(CC)CCNc1nc(nc2cc(F)c(Oc3c(C)cccc3C)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C26H29FN6O3/c1-5-32(6-2)11-10-28-24-19-12-22(36-23-16(3)8-7-9-17(23)4)20(27)13-21(19)30-26(31-24)33-15-18(14-29-33)25(34)35/h7-9,12-15H,5-6,10-11H2,1-4H3,(H,34,35)(H,28,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.26E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373692
PNG
(1-(6-Isopropyl-4-morpholinoquinazolin-2-yl)-1H-pyr...)
Show SMILES CC(C)c1ccc2nc(nc(N3CCOCC3)c2c1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C19H21N5O3/c1-12(2)13-3-4-16-15(9-13)17(23-5-7-27-8-6-23)22-19(21-16)24-11-14(10-20-24)18(25)26/h3-4,9-12H,5-8H2,1-2H3,(H,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373635
PNG
(1-(7-Phenyl-4-(pyrrolidin-1-yl)quinazolin-2-yl)-1H...)
Show SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCC2)c2ccc(cc2n1)-c1ccccc1
Show InChI InChI=1S/C22H19N5O2/c28-21(29)17-13-23-27(14-17)22-24-19-12-16(15-6-2-1-3-7-15)8-9-18(19)20(25-22)26-10-4-5-11-26/h1-3,6-9,12-14H,4-5,10-11H2,(H,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.16E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%